AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth CareGeographicals
LeuconostocaceaeLactobacillalesGlutamate DehydrogenaseGenomicsSodium-Hydrogen AntiporterMolecular Sequence DataGenome, BacterialMycoplasma gallisepticumArchivesMycoplasmaBiological Science DisciplinesPeriodicals as TopicPubMedDirectories as TopicBacteroidesBacteroides fragilisBacteroides InfectionsPrevotellaTetracycline ResistanceConjugation, GeneticR FactorsReceptors, LipoproteinLipoproteins, HDLADP-ribosyl CyclaseSearch EngineLipoproteins, LDLLipoproteinsReceptors, LDLOregonCrowsBibliometricsPublicationsState Health PlansPublishingArgininosuccinate SynthaseArginineArgininosuccinate LyaseCitrullineArginaseCell Line, TumorEquidaeIndividualized MedicineHealth Maintenance OrganizationsDermatoglyphicsDNA FingerprintingTaiwanResearchDivingCanadaMetabolomicsBritish ColumbiaAlbertaAcademies and InstitutesMetabolome
Leuconostocaceae
A family of gram-positive bacteria in the order Lactobacillales. Lactic acid is the main product of their carbohydrate metabolism.
Lactobacillales
An order of gram-positive bacteria in the class Bacilli, that have the ability to ferment sugars to lactic acid. They are widespread in nature and commonly used to produce fermented foods.
Glutamate Dehydrogenase
An enzyme that catalyzes the conversion of L-glutamate and water to 2-oxoglutarate and NH3 in the presence of NAD+. (From Enzyme Nomenclature, 1992) EC 1.4.1.2.
Genomics
The systematic study of the complete DNA sequences (GENOME) of organisms.
Sodium-Hydrogen Antiporter
A plasma membrane exchange glycoprotein transporter that functions in intracellular pH regulation, cell volume regulation, and cellular response to many different hormones and mitogens.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Genome, Bacterial
The genetic complement of a BACTERIA as represented in its DNA.
Mycoplasma gallisepticum
A species of gram-negative bacteria causing chronic respiratory disease in POULTRY.
Archives
Mycoplasma
A genus of gram-negative, mostly facultatively anaerobic bacteria in the family MYCOPLASMATACEAE. The cells are bounded by a PLASMA MEMBRANE and lack a true CELL WALL. Its organisms are pathogens found on the MUCOUS MEMBRANES of humans, ANIMALS, and BIRDS.
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Periodicals as Topic
A publication issued at stated, more or less regular, intervals.
PubMed
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
Directories as Topic
Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)
Bacteroides
A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.
Bacteroides fragilis
Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.
Bacteroides Infections
Infections with bacteria of the genus BACTEROIDES.
Prevotella
A genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods. Organisms of this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings in 1990 indicated the need to separate them from other Bacteroides species, and hence, this new genus was established.
Tetracycline Resistance
Nonsusceptibility of bacteria to the action of TETRACYCLINE which inhibits aminoacyl-tRNA binding to the 30S ribosomal subunit during protein synthesis.
Conjugation, Genetic
A parasexual process in BACTERIA; ALGAE; FUNGI; and ciliate EUKARYOTA for achieving exchange of chromosome material during fusion of two cells. In bacteria, this is a uni-directional transfer of genetic material; in protozoa it is a bi-directional exchange. In algae and fungi, it is a form of sexual reproduction, with the union of male and female gametes.
R Factors
A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
Receptors, Lipoprotein
Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.
Lipoproteins, HDL
A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.
ADP-ribosyl Cyclase
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Search Engine
Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.
Lipoproteins, LDL
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
Lipoproteins
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
Receptors, LDL
Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.
Oregon
Crows
Common name for the largest birds in the order PASSERIFORMES, family Corvidae. These omnivorous black birds comprise most of the species in the genus Corvus, along with ravens and jackdaws (which are often also referred to as crows).
Bibliometrics
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
Publications
Copies of a work or document distributed to the public by sale, rental, lease, or lending. (From ALA Glossary of Library and Information Science, 1983, p181)
State Health Plans
State plans prepared by the State Health Planning and Development Agencies which are made up from plans submitted by the Health Systems Agencies and subject to review and revision by the Statewide Health Coordinating Council.
Publishing
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
Argininosuccinate Synthase
An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
Arginine
An essential amino acid that is physiologically active in the L-form.
Argininosuccinate Lyase
An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC ACIDURIA in man. EC 4.3.2.1.
Citrulline
Arginase
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.
Cell Line, Tumor
A cell line derived from cultured tumor cells.
Equidae
A family of hoofed MAMMALS consisting of HORSES, donkeys, and zebras. Members of this family are strict herbivores and can be classified as either browsers or grazers depending on how they feed.
Individualized Medicine
Therapeutic approach tailoring therapy for genetically defined subgroups of patients.
Health Maintenance Organizations
Organized systems for providing comprehensive prepaid health care that have five basic attributes: (1) provide care in a defined geographic area; (2) provide or ensure delivery of an agreed-upon set of basic and supplemental health maintenance and treatment services; (3) provide care to a voluntarily enrolled group of persons; (4) require their enrollees to use the services of designated providers; and (5) receive reimbursement through a predetermined, fixed, periodic prepayment made by the enrollee without regard to the degree of services provided. (From Facts on File Dictionary of Health Care Management, 1988)
Dermatoglyphics
The study of the patterns of ridges of the skin of the fingers, palms, toes, and soles.
DNA Fingerprinting
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Taiwan
Research
Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)
Diving
An activity in which the organism plunges into water. It includes scuba and bell diving. Diving as natural behavior of animals goes here, as well as diving in decompression experiments with humans or animals.
Canada
The largest country in North America, comprising 10 provinces and three territories. Its capital is Ottawa.
Metabolomics
The systematic identification and quantitation of all the metabolic products of a cell, tissue, organ, or organism under varying conditions. The METABOLOME of a cell or organism is a dynamic collection of metabolites which represent its net response to current conditions.
British Columbia
A province of Canada on the Pacific coast. Its capital is Victoria. The name given in 1858 derives from the Columbia River which was named by the American captain Robert Gray for his ship Columbia which in turn was named for Columbus. (From Webster's New Geographical Dictionary, 1988, p178 & Room, Brewer's Dictionary of Names, 1992, p81-2)
Alberta
A province of western Canada, lying between the provinces of British Columbia and Saskatchewan. Its capital is Edmonton. It was named in honor of Princess Louise Caroline Alberta, the fourth daughter of Queen Victoria. (From Webster's New Geographical Dictionary, 1988, p26 & Room, Brewer's Dictionary of Names, 1992, p12)
Academies and Institutes
Organizations representing specialized fields which are accepted as authoritative; may be non-governmental, university or an independent research organization, e.g., National Academy of Sciences, Brookings Institution, etc.
Metabolome
The dynamic collection of metabolites which represent a cell's or organism's net metabolic response to current conditions.

L-Asparagine synthetase in serum as a marker for neoplasia. (1/128)

L-Asparagine synthetase appears in serum approximately 7 days after the s.c. implantation of 1 X 10(5) cells of Leukemia 5178Y/AR (resistant to L-asparaginase) and increases in activity as the neoplasm grows and metastasizes. The principal source of the enzyme is the primary tumor. After intravranial inoculation of tumor, the rate of leakage of the enzyme is more pronounced than when the subcutaneous, intramuscular, or intraperitoneal routes are used. 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037), a nitro-sourea effective in the palliation of L5178Y/AR, temporarily halts the influx of enzyme into the blood stream, as does surgical excision of the s.c. tumor nodules. Treatment of mice with L-asparaginase within 24 hr of inoculation of the tumor markedly augments both tumor growth and the rate of penetration of L-asparagine synthetase into the circulation. Several other L-asparagine synthetase into the circulation. Several other L-asparaginase-resistant tumors also were found to spill L-asparagine synthetase into the serum, but the correlation between this phenomenon and the specific activity of the enzyme in homogenates of the tumor was imperfect.  (+info)

Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability. (2/128)

Transcription of the asparagine synthetase (AS) gene is induced by amino acid deprivation. The present data illustrate that this gene is also under transcriptional control by carbohydrate availability. Incubation of human HepG2 hepatoma cells in glucose-free medium resulted in an increased AS mRNA content, reaching a maximum of about 14-fold over control cells after approx. 12 h. Extracellular glucose caused the repression of the content of AS mRNA in a concentration-dependent manner, with a k1/2 (concentration causing a half-maximal repression) of 1 mM. Fructose, galactose, mannose, 2-deoxyglucose and xylitol were found to maintain the mRNA content of both AS and the glucose-regulated protein GRP78 in a state of repression, whereas 3-O-methylglucose did not. Incubation in either histidine-free or glucose-free medium also resulted in adaptive regulation of the AS gene in BNL-CL.2 mouse hepatocytes, rat C6 glioma cells and human MOLT4 lymphocytes, in addition to HepG2 cells. In contrast, the steady-state mRNA content of GRP78 was unaffected by amino acid availability. Transient transfection assays using a reporter gene construct documented that glucose deprivation increases AS gene transcription via elements within the proximal 3 kbp of the AS promoter. These results illustrate that human AS gene transcription is induced following glucose limitation of the cells.  (+info)

RT-PCR cloning, characterization and mRNA expression analysis of a cDNA encoding a type II asparagine synthetase in common bean. (3/128)

Following a RT-PCR strategy based on the design of degenerate oligonucleotides resembling conserved domains of asparagine synthetase (AS; EC 6.3.5.4), we isolated a 2 kb cDNA clone (PVAS2) from root tissue of the common bean (Phaseolus vulgaris). PVAS2 encodes a protein of 584 amino acids with a predicted relative molecular mass of 65810 Da, an isoelectric point of 6.4, and a net charge of -7.2 at pH 7.0. The amino acid sequence of the protein encoded by PVAS2 is very similar to that encoded by the soybean SAS2 asparagine synthetase gene. The amino-terminal residues of the predicted PVAS2 protein are identical to the amino acids that constitute the glutamine-binding (GAT) domain of AS from other plant species, which suggests that the PVAS2 cDNA encodes a type II glutamine-dependent form of asparagine synthetase. Southern blot analysis indicates that the common bean AS is part of a small family composed of at least two genes. Expression analysis by Northern blot revealed that the PVAS2 transcript accumulates to a high level in roots and, to a lesser extent, in nodules and developing pods. Accumulation of the PVAS2 transcript in the root seems to be negatively regulated by light and sucrose, and positively regulated by nitrate.  (+info)

Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression. (4/128)

The gene for the amino acid biosynthetic activity asparagine synthetase (AS) is induced by both amino acid and glucose deprivation of cells. The data reported here document that the human AS gene is induced following activation of the Unfolded Response Pathway (UPR), also known as the Endoplasmic Reticulum Stress Response (ERSR) in mammals. Increased AS transcription occurs in response to glucose deprivation, tunicamycin, or azetidine-2-carboxylate, all known to activate the UPR/ERSR pathway. Previously identified ERSR target genes contain multiple copies of a single highly conserved cis-element. In contrast, the human AS gene does not contain the ERSR element, as it has been described for other responsive genes. Instead, AS induction requires an Sp1-like sequence, a sequence previously shown to be associated with amino acid control of transcription, and possibly, a third region containing no consensus sequences for known transcription factors. Oligonucleotides covering each of these regions form DNA-protein complexes in vitro, and for some the amount of these complexes is greater when nuclear extracts from glucose-starved cells are tested. These results document that a wider range of metabolic activities are activated by the UPR/ERSR pathway than previously recognized and that genomic elements other than those already described can serve to enhance transcription of specific target genes.  (+info)

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis. (5/128)

The gene thiI encodes a protein (ThiI) that plays a role in the transfer of sulfur from cysteine to both thiamin and 4-thiouridine, but the reaction catalyzed by ThiI remains undetermined. Based upon sequence alignments, ThiI shares a unique "P-loop" motif with the PPi synthetase family, four enzymes that catalyze adenylation and subsequent substitution of carbonyl oxygens. To test whether or not this motif is critical for ThiI function, the Asp in the motif was converted to Ala (D189A), and a screen for in vivo 4-thiouridine production revealed the altered enzyme to be inactive. Further scrutiny of sequence data and the crystal structures of two members of the PPi synthetase family implicated Lys321 in the proposed adenylation function of ThiI, and the critical nature of Lys321 has been demonstrated by site-directed mutagenesis and genetic screening. Our results, then, indicate that ThiI catalyzes the adenylation of a substrate at the expense of ATP, a narrowing of possible reactions that provides a strong new basis for deducing the early steps in the transfer of sulfur from cysteine to both thiamin and 4-thiouridine.  (+info)

A mutation in the Corynebacterium glutamicum ltsA gene causes susceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production. (6/128)

The Corynebacterium glutamicum mutant KY9714, originally isolated as a lysozyme-sensitive mutant, does not grow at 37 degrees C. Complementation tests and DNA sequencing analysis revealed that a mutation in a single gene of 1,920 bp, ltsA (lysozyme and temperature sensitive), was responsible for its lysozyme sensitivity and temperature sensitivity. The ltsA gene encodes a protein homologous to the glutamine-dependent asparagine synthetases of various organisms, but it could not rescue the asparagine auxotrophy of an Escherichia coli asnA asnB double mutant. Replacement of the N-terminal Cys residue (which is conserved in glutamine-dependent amidotransferases and is essential for enzyme activity) by an Ala residue resulted in the loss of complementation in C. glutamicum. The mutant ltsA gene has an amber mutation, and the disruption of the ltsA gene caused lysozyme and temperature sensitivity similar to that in the KY9714 mutant. L-Glutamate production was induced by elevating growth temperature in the disruptant. These results indicate that the ltsA gene encodes a novel glutamine-dependent amidotransferase that is involved in the mechanisms of formation of rigid cell wall structure and in the L-glutamate production of C. glutamicum.  (+info)

Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. (7/128)

In mammals, plasma concentrations of amino acids (AA) are affected by nutritional or pathologic conditions. Alterations in AA profiles have been reported as a result of a deficiency of any one of the essential AA, a dietary imbalance of AA or an insufficient intake of protein. In recent years, evidence has accumulated that AA availability regulates the expression of several genes involved in the regulation of a number of cellular functions or AA metabolism. Nevertheless, the molecular mechanisms involved in the AA regulation of mammalian gene expression are limited, particularly the signaling pathways mediating the AA response. This work provides a better understanding of the signaling pathways involved in the AA control of gene expression. We studied the expression of C/EBP homologous protein (CHOP) and asparagine synthetase (AS) in response to deprivation of a single AA and investigated the possible link between protein synthesis inhibition due to amino acid limitation and gene expression. We have shown the following: 1) several mechanisms are involved in the AA control of gene expression. When omitted from the culture medium, each AA can activate one (or several) specific signaling pathways leading to the regulation of one specific pattern of genes. 2) AA limitation by itself can induce gene expression independently of a cellular stress due to protein synthesis inhibition. Together, these results suggest that AA control of gene expression involves several specific mechanisms by which one AA (or one group of AA) can activate one signaling pathway and thus alter one specific pattern of gene expression.  (+info)

Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. (8/128)

The human asparagine synthetase (AS) gene is transcriptionally regulated by amino acid deprivation (amino acid response, AAR) and the endoplasmic reticulum stress response (ERSR), also known as the unfolded protein response pathway. The results reported here document the novel observation that induction of the AS gene by the AAR and ERSR pathways occurs via the same set of genomic elements. Data supporting this conclusion include transient transfection of AS promoter/reporter gene constructs that illustrate that the transcriptional control elements used by both pathways are contained with nucleotides -111 to -34 of the AS promoter. In vivo footprinting analysis of this region identified six specific protein-binding sites. Within two of these sites, altered footprinting was observed following amino acid or glucose deprivation, but the patterns were identical for both the AAR and the ERSR pathway. Site-directed mutation of individual nucleotides within these two binding sites confirmed their importance for regulated transcription, and none of the mutations resulted in loss of response of only one pathway. Neither of these two sites corresponds to a recently identified ERSR cis-element, nor do they contain consensus sequences for known transcription factors. Collectively, the data document that there are at least two independent transcriptional mechanisms for gene activation by the ERSR pathway, one of which terminates at the same genomic elements used by the AAR pathway.  (+info)

Asparagine synthase (glutamine-hydrolysing) - WikipediaAsparagine synthase (glutamine-hydrolysing) - Wikipedia
Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I (December 1999). Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry. 38 (49): 16146-57. CiteSeerX 10.1.1.453.5998. doi:10.1021/bi9915768. PMID 10587437 ...
https://en.wikipedia.org/wiki/Asparagine_synthase_
OriGene - ASNS (NM 001178076) Human ORF cDNA CloneOriGene - ASNS (NM 001178076) Human ORF cDNA Clone
ASNS - ASNS (Myc-DDK-tagged)-Human asparagine synthetase (glutamine-hydrolyzing) (ASNS), transcript variant 5 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/orf_clone/trueclone/NM_001178076/RC230144/ASNS.aspx
Aspartate-Ammonia Ligase - Asparagine Synthetase Summary Report | CureHunterAspartate-Ammonia Ligase - Asparagine Synthetase Summary Report | CureHunter
Aspartate-Ammonia Ligase: An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP. EC 6.3.1.1.
http://www.curehunter.com/public/keywordSummaryD001217-Aspartate-Ammonia-Ligase-Asparagine-Synthetase.do
ASNS Gene - GeneCards | ASNS Protein | ASNS AntibodyASNS Gene - GeneCards | ASNS Protein | ASNS Antibody
Complete information for ASNS gene (Protein Coding), Asparagine Synthetase (Glutamine-Hydrolyzing), including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASNS
Plus itPlus it
Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors. Asparagine is an amino acid that is synthesized by normal cells. However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis. Asparaginase (ASNase) contributes to eradication of acute leukemia by decreasing asparagine levels in serum and cerebrospinal fluid. However, leukemic cells may become ASNase-resistant by up-regulating ASNS. High expression of ASNS has also been associated with biological aggressiveness of other cancers, including gliomas. Here, the impact of enzymatic depletion of asparagine on proliferation of brain tumor cells was determined. ASNase was used as monotherapy or in combination with conventional chemotherapeutic agents. Viability assays for ASNase-treated cells demonstrated significant growth reduction in multiple cell lines. This effect was reversed by glutamine in a dose-dependent manner -- as expected, because glutamine is the main amino ...
http://mcr.aacrjournals.org/content/early/2014/02/06/1541-7786.MCR-13-0576
Asparagine synthetase Overexpression Lysate (Adult Normal), Novus Biologicals (NBL1-07768) | VWRAsparagine synthetase Overexpression Lysate (Adult Normal), Novus Biologicals (NBL1-07768) | VWR
Special note about Community Feature Content. Any content and/or opinions uploaded, expressed or submitted through any Community Feature or any other publicly available section of the Web Site (including password-protected areas), and all articles and responses to questions, other than the content explicitly authorized by the Company, are solely the opinions and responsibility of the person or entity submitting them and do not necessarily reflect the opinions of the Company. By way of example, any recommended or suggested use of products or services available from the Company that is posted through a Community Feature is not a sign of approval or recommendation by the Company. If you choose to follow any such recommendation you do so at your own risk.. Links to Third Party Sites. The Web Site may contain links to other websites on the internet. The Company is not responsible for the content, products, services or practices of any third party websites, including without limitation sites linked to ...
https://us.vwr.com/store/product/9696419/asparagine-synthetase-overexpression-lysate-adult-normal-novus-biologicals-nbl1-07768
WikiGenes - ASNSD1 - asparagine synthetase domain containing 1WikiGenes - ASNSD1 - asparagine synthetase domain containing 1
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
https://www.wikigenes.org/e/gene/e/54529.html
Limiting Dietary Asparagine Could Reduce Cancer SpreadLimiting Dietary Asparagine Could Reduce Cancer Spread
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
https://www.technologynetworks.com/applied-sciences/news/limiting-dietary-asparagine-could-reduce-cancer-spread-297287
Anti-Asparagine synthetase antibody [EP282Y] (ab40850)Anti-Asparagine synthetase antibody [EP282Y] (ab40850)
Rabbit recombinant monoclonal Asparagine synthetase antibody [EP282Y] validated for WB, IHC, ICC/IF and tested in Human, Mouse and Rat. Referenced in 3…
http://www.abcam.com/asparagine-synthetase-antibody-ep282y-ab40850.html
INRA - NitroScapeINRA - NitroScape
NitroScape is an integrated modelling tool that simulates at landscape level the entire nitrogen transfer and transformation process. The most effective scale for developing nitrogen mitigation strategies is landscape level.
http://www.inra.fr/en/Scientists-Students/Agricultural-systems/All-reports/Modelling-and-agrosystems/NitroScape/
Root parasite induced nitrogen transfer between plants is density dependent - Citation formats | Research Explorer | The...Root parasite induced nitrogen transfer between plants is density dependent - Citation formats | Research Explorer | The...
TY - JOUR. T1 - Root parasite induced nitrogen transfer between plants is density dependent. AU - Dromph, Karsten M.. AU - Cook, Roger. AU - Ostle, Nick J.. AU - Bardgett, Richard D.. N1 - Dromph, Karsten M. Cook, Roger Ostle, Nick J. Bardgett, Richard D.. PY - 2006/8. Y1 - 2006/8. N2 - Recent studies point to the importance of soil borne parasites as agents of vegetation change via their negative effect on host plants. Here we show that these soil organisms can influence vegetation characteristics by increasing the transfer of the plant growth-limiting nutrient nitrogen (N) from their host, a N-fixing legume, to neighbouring grass species, thereby benefiting the growth of the neighbour. Furthermore, the amount of N transferred from the legume to the neighbour, and its consequent effect on the neighbours growth, was dependant on the density of root infestation. This mechanism of N transfer from legumes to neighbouring plant species is likely to be an important agent of vegetation change. © 2006 ...
https://www.research.manchester.ac.uk/portal/en/publications/root-parasite-induced-nitrogen-transfer-between-plants-is-density-dependent
anti-Asparagine synthetase antibody | GeneTexanti-Asparagine synthetase antibody | GeneTex
Asparagine synthetase antibody (asparagine synthetase (glutamine-hydrolyzing)) for IHC-P, WB. Anti-Asparagine synthetase pAb (GTX114269) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/Asparagine-synthetase-antibody-GTX114269.html
ASNS Antibody (monoclonal) (M01) - Mouse monoclonal antibody raised against a partial recombinant ASNS. E - Buy Now! |AbgentASNS Antibody (monoclonal) (M01) - Mouse monoclonal antibody raised against a partial recombinant ASNS. E - Buy Now! |Abgent
ASNS Antibody (monoclonal) (M01), Mouse monoclonal antibody raised against a partial recombinant ASNS. validated in E (AT1217a), Abgent
http://www.abgent.com/products/AT1217a-ASNS-Antibody-monoclonal-M01
The Yang Research Group - Members - Hee Sun ChungThe Yang Research Group - Members - Hee Sun Chung
L-Asparaginase (ASNase) is a drug used in treatment of acute lymphoblastic leukemia. In presence of this enzyme the asparagine, an essential amino acid for biosynthesis, is converted to aspartic acid and ammonia. The malignant cells in patients with ASNase sensitive leukemia depend on exogenous supply of asparagine for survival. Administration of ASNase results in rapid reduction of systemic asparagine causing apoptosis of cancer cells. The effect of this enzyme on normal cells is not significant compared to the malignant cells as the normal cells are capable of generating their own source of asparagine through aspartic acid by way of asparagine synthetase.. Despite its effectiveness, the use of ASNase is not without problems. Due to its bacterial origin, namely E. coli and Erwinia carotovora, ASNase causes immunogenic response in patients and requires administration in hospital setting. The problem is compounded by the fact that ASNase has short half-life which in turn necessitates frequent ...
http://www-personal.umich.edu/~vcyang/html/heesunchung.htm
Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation on...Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation on...
Article Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation. Pho85 cyclins (Pcls), activators of the yeast cyclin-dependent kinase (CDK) Pho85, belong together with the p35 activator of ...
https://www.environmental-expert.com/articles/autophosphorylation-induced-degradation-of-the-pho85-cyclin-pcl5-is-essential-for-response-to-amino--39570
Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from AbcamRabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam
Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam,Rabbit monoclonal [EP282Y] to Asparagine synthetase ( P08243,biological,biology supply,biology supplies,biology product
http://www.bio-medicine.org/biology-products/Rabbit-Anti-Asparagine-synthetase-Monoclonal-Antibody--Unconjugated--Clone-EP282Y-from-Abcam-5681-1/
RCSB PDB for 11ASRCSB PDB for 11AS
11AS: Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase.
http://www.rcsb.org/pdb/explore/biologyAndChemistry.do?structureId=11AS
ASNSP4 Gene - GeneCards | ASNSP4 PseudogeneASNSP4 Gene - GeneCards | ASNSP4 Pseudogene
Complete information for ASNSP4 gene (Pseudogene), Asparagine Synthetase Pseudogene 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASNSP4
Sočasna okužba - Wikipedija, prosta enciklopedijaSočasna okužba - Wikipedija, prosta enciklopedija
Sočasna okužba, sookužba ali koinfekcija je hkratna okužba celice ali organizma z dvema mikroorganizmoma (na primer pljučnica, ki jo povzročata ortomiksovirus in streptokok).[1] Kadar pa se nova okužba pridruži že obstoječi kasneje in ne istočasno, govorimo o nadokužbi (naknadni okužbi).[2] V svetovnem merilu je pogosta sookužba z jetiko (tuberkulozo) in HIV-om. V nekaterih državah je do 80 % bolnikov s tuberkulozo okuženih tudi z virusom HIV.[3] Nadalje je okoli 10 % bolnikov, okuženih s HIV-om, sočasno okuženih tudi z virusom hepatitisa B.[4] Pri okužbi s HIV-om pa je možna tudi sookužba z več sevi istega virusa; kadar pa se bolnik najprej okuži z enim sevom virusa, kasneje v življenju pa še z drugim, gre za nadokužbo.[5] ...
https://sl.wikipedia.org/wiki/So%C4%8Dasna_oku%C5%BEba
Publications | FIREPublications | FIRE
Billen G, Garnier J, Lassaletta L. 2013. The nitrogen cascade from agricultural soils to the sea: modelling nitrogen transfers at regional watershed and global scales. Philosophical Transactions of the Royal Society B: Biological Sciences. 368:20130123-20130123. ...
https://www.fire.upmc.fr/?q=en/biblio&page=1&%3Bamp%3Bf%5Bkeyword%5D=489&%3Bamp%3Bs=title&%3Bamp%3Bo=asc&%3Bf%5Bauthor%5D=1788&f%5Bauthor%5D=353&s=type&o=asc
Publications | FIREPublications | FIRE
Billen G, Garnier J, Lassaletta L. 2013. The nitrogen cascade from agricultural soils to the sea: modelling nitrogen transfers at regional watershed and global scales. Philosophical Transactions of the Royal Society B: Biological Sciences. 368:20130123-20130123. ...
https://www.fire.upmc.fr/?q=en/biblio&%3Bamp%3Bf%5Bkeyword%5D=376&%3Bamp%3Bf%5Bauthor%5D=227&%3Bf%5Bauthor%5D=1361&f%5Bauthor%5D=353&s=type&o=desc
The side chain of serine can form a hydrogen bond... - OpenStudyThe side chain of serine can form a hydrogen bond... - OpenStudy
The side chain of serine can form a hydrogen bond with the side chain of which of the following amino acids? threonine asparigine Can someone expla...
http://openstudy.com/updates/4fd76229e4b08820575626bc
physiology test question xW8cW2g0mme2z2yeBqiy2DQromZiLo4T.htmlphysiology test question xW8cW2g0mme2z2yeBqiy2DQromZiLo4T.html
Physiology Test Question - Which of the following amino acids serves as a precursor or intermediary metabolite in the biosynthetic pathway of the neurotransmitter/hormone epinephrine?
http://www.physiologyweb.com/test_questions/physiology_test_question_xW8cW2g0mme2z2yeBqiy2DQromZiLo4T.html
Researchers discover glutamine-dependent activation of cell growth and autophagyResearchers discover glutamine-dependent activation of cell growth and autophagy
The human body consists of about 35 trillion cells, so it could be said that overall body growth is the growth of individual cells.
https://www.news-medical.net/news/20180503/Researchers-discover-glutamine-dependent-activation-of-cell-growth-and-autophagy.aspx
Gentaur Molecular :Sceti K.K. \ L Asparagine \ 2703Gentaur Molecular :Sceti K.K. \ L Asparagine \ 2703
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Skopolamin - Wikipedija, prosta enciklopedijaSkopolamin - Wikipedija, prosta enciklopedija
Pogosti stranski učinki so povezani z antiholinergičnim delovanjem na parasimpatične postsinaptične receptorje: suha usta, grlo, nos, ob prekomernih odmerkih oslabljen govor, ki se lahko stopnjuje do mrmranja, podobnega glasovom rakuna; žeja, zamegljen vid in občutljivost na svetlobo, zaprtje, težave pri uriniranju in tahikardija. Ostali stranski učinki: pordelost, povišana temperatura, razburjenje, nemirnost, halucinacije, delirij, sploh pri višjih odmerkih. Našteti stranski učinki nastopijo ob peroralni ali parenteralni aplikaciji učinkovine, ne pa ob topični ali okularni uporabi. Ekstremni zaplet ob zaužitju zelo visokih odmerkov skopolamina in sorodnih drog je začasna slepota, ki lahko traja do 72 ur.. Vročina in izsušitev zaradi skopolamina lahko prisilita uporabnike tega mamila, da se poskušajo ohladiti v različnih vodnih zajetjih in se tam utopijo.. Stranski učinki skopolamina se lahko zamenjajo za simptome raka zaradi prisotne slabosti in različno velikih zenic ...
https://sl.wikipedia.org/wiki/Skopolamin
Human Metabolome Database: Showing metabocard for L-Asparagine (HMDB0000168)Human Metabolome Database: Showing metabocard for L-Asparagine (HMDB0000168)
Asparagine (Asn) is one of the 20 most common natural amino acids on Earth. It has carboxamide as the side chains functional group. Asparagine is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. The precursor to asparagine is oxaloacetate. Oxaloacetate is converted to aspartate using a transaminase enzyme. The enzyme transfers the amino group from glutamate to oxaloacetate producing alpha-ketoglutarate and aspartate. The enzyme asparagine synthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. In the asparagine synthetase reaction, ATP is used to activate aspartate, forming beta-aspartyl-AMP. Glutamine donates an ammonium group which reacts with beta-aspartyl-AMP to form asparagine and free AMP. Since the asparagine side chain can make efficient hydrogen bond interactions with the peptide backbone, asparagines are often found near the beginning ...
https://hmdb.ca/metabolites/HMDB0000168
Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein responseAmino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response
The gene encoding CHOP (C/EBP-homologous protein) is transcriptionally activated by many stimuli and by amino acid deprivation. CHOP induction was considered to be due to an accumulation of unfolded protein into the ER (unfolded protein response (UPR)). We investigate the role of the UPR in the indu …
https://pubmed.ncbi.nlm.nih.gov/10218478/?dopt=Abstract
CAS 154395-64-9 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-Asparagine - BOC SciencesCAS 154395-64-9 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-Asparagine - BOC Sciences
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Eine neuartige 1,2-Methyl-Wanderung bei der Desaminierung Decarboxylierung von 3- Amino-CyclopentancarbonsäurenEine neuartige 1,2-Methyl-Wanderung bei der Desaminierung Decarboxylierung von 3- Amino-Cyclopentancarbonsäuren
During deamination, γ-amino acids can undergo concomitant decarboxylation. Aiming at studying the course of the involved reaction, the following γ-amino acids were synthesized and characterized: (-)-3c-amino-1,2,2-trimethylcyclopentane-1r-carboxylic acid (= (-)-aminolauronic acid = (-)-3-aminocamphonanic acid; 39), cis-3-aminocyclopentanecarboxylic acid (41), (+)-3c-amino-2,2,3-trimethylcyclopentane-1r-carboxylic acid (= (-)-aminodihydrocampholytic acid; 42), and the novel (±)-cis-3-amino-2,2-dimethylcyclopentanecarboxylic acid (43). These γ-amino acids were deaminated by means of 4-diazoniobenzenesulfonate (= p-diazobenzenesulfonic acid; generated from p-sulfanilic acid = 4-aminobenzenesulfonic acid), under moderately basic aqueous conditions (pH 8-9). The formed product mixtures were separated, the products identified, and their structures correlated with the starting γ-amino acids, thus establishing that decarboxylation occurs whenever the carbenium ion formed by loss of nitrogen can ...
https://infoscience.epfl.ch/record/30615
Asparagine essential for brain development | Health24Asparagine essential for brain development | Health24
The amino acid asparagine was until now considered non-essential because it is produced naturally by the body. However, researchers found that it is essential for normal brain development.
http://www.health24.com/Mental-Health/Brain/News/Asparagine-essential-for-brain-development-20131125
Gentaur Molecular :Biosera \ L Asparagine Monohydrate 100g \ PM-P1404/100Gentaur Molecular :Biosera \ L Asparagine Monohydrate 100g \ PM-P1404/100
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Hebrew Universitys Methylation Maestro | CFHUHebrew Universitys Methylation Maestro | CFHU
Lab rat. Cedar says he was not the best student in NYUs MD/PhD program, but he did enjoy learning about the life sciences. I was infatuated with general biology principles. It was the beginning of the molecular biology revolution, says Cedar. After three years of medical school and clinical rotations, Cedar chose to work with James Schwartz, who started at NYU as a microbiologist and then became a neurobiologist, using the sea slug Aplysia to study how memory works. Part of Schwartzs research included examining how learning affects chromatin structure. Cedar was Schwartzs first graduate student. Its very good to be the first graduate student; you get a lot of attention, says Cedar. He studied E. colis synthesis of L-asparaginase, which catalyzes the hydrolysis of the amino acid asparagine to aspartic acid, and purified asparagine synthetase from the bacterium to study how that enzyme catalyzes the reverse reaction, using aspartate to produce the amino acid in vitro. Cedar enjoyed ...
http://www.cfhu.org/news/hebrew-universitys-methylation-maestro
Measurement of Serum l-Asparagine in the Presence of l-Asparaginase Requires the Presence of an l-Asparaginase Inhibitor |...Measurement of Serum l-Asparagine in the Presence of l-Asparaginase Requires the Presence of an l-Asparaginase Inhibitor |...
The antileukemic activity of l-asparaginase (ASNase), an important component of therapy for acute lymphoblastic leukemia, is thought to result from depletion of serum l-asparagine (Asn). In studies of the pharmacological effects of ASNase, investigators have reported prolonged reduction in the serum concentration of Asn after the administration of ASNase. Such measurements may not be valid because ASNase present in the blood sample may hydrolyze Asn before its determination. We examined recovery of [U-14C]Asn from blood samples with and without various concentrations of added ASNase. In the presence of ≥0.01 IU/ml of ASNase, the amount of [U-14C]Asn recovered was ,15% of that without ASNase. Utilizing this assay, we studied the effect of 2 known inhibitors of ASNase in an attempt to improve Asn recovery. In the presence of aspartic β semialdehyde (ASA), or 5-diazo-4-oxo-l-norvaline (DONV), and up to 1.0 IU/ml ASNase, Asn levels remained at ,90% of control. ASA prevented the hydrolysis of ...
http://cancerres.aacrjournals.org/content/51/24/6568.long
KGI | About KGI | Administration | Sheldon SchusterKGI | About KGI | Administration | Sheldon Schuster
Research and Publications. Schusters research focused on finding new targets for synthesizing mechanism-based inhibitors of disease-related enzymes by studying the relationship between the structure and function of ATP synthase and asparagine synthetase. Schuster also examined the role of mycoplasmal infections in the progression of malignant tumors. His research has been published in the journal Biochemistry. He also has written commentaries that appeared in the journal Biochemistry and Molecular Biology Education.. Honors and Service. Schuster has been active in professional organizations such as the Biotechnology Innovation Organization (BIO) and the Council for Biotechnology Centers. He currently is a features editor of the journal Biochemistry and Molecular Biology Education and a member of its editorial board.. In 2007, the American Association for the Advancement of Science elected Schuster as an AAAS Fellow, an honor given by members to their peers who have made significant ...
http://www.kgi.edu/about-kgi/administration/sheldon-schuster
China High Quality L-Asparagine - China L-AsparagineChina High Quality L-Asparagine - China L-Asparagine
China High Quality L-Asparagine, Find details about China L-Asparagine from High Quality L-Asparagine - Qingdao Sunrise Biotechnology Co., Ltd.
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Plus itPlus it
This study shows a critical role for Asna1 in ensuring β-cell function. Loss of Asna1 in β-cells of mice results in pancreatic hypoinsulinemia, impaired insulin secretion, and early onset diabetes. Additionally, β-cells of Asna1β−/− mice showed impaired PM-to-TGN as well as Golgi-to-ER retrograde transport, ER stress, and mislocalization of Stx5 and Stx6. Of note, we also show that inhibition of retrograde transport at the level of EE-to-TGN in isolated islet and insulinoma cells results in impaired Golgi-to-ER retrograde transport, decreased insulin content, and ER stress. Thus, the findings provide evidence that Asna1 is required in β-cells to ensure retrograde transport, which in turn appears to be essential for ER homeostasis and proinsulin biogenesis. Additionally, the perturbed Golgi-to-ER retrograde transport in Retro-2-treated primary islets suggests that the impairment of this step in Asna1β−/− β-cells likely is secondary to the inhibition of retrograde transport at the ...
http://diabetes.diabetesjournals.org/content/65/1/110
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial))ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial))
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/GC_ASNA1.html
Asparagine, molecular model - Stock Image A611/0042 - Science Photo LibraryAsparagine, molecular model - Stock Image A611/0042 - Science Photo Library
Asparagine. Molecular model of the amino acid asparagine. Its chemical formula is C4.H8.N2.O3. Atoms are represented as spheres and are colour- coded: carbon (blue), hydrogen (gold), oxygen (red) and nitrogen (dark blue). Amino acids are the building blocks of proteins. Asparagine is a non-essential amino acid. It can be synthesised by the body and so does not need to come from the diet. Asparagine plays an important role in the folding of protein molecules into their secondary structures (alpha helices and beta sheets). Some proteins (such as haemoglobin, the oxygen- carrying pigment in human blood) cannot function without being folded into the correct shape. - Stock Image A611/0042
http://www.sciencephoto.com/media/6503/view
L-asparagine oxygenase elisa and antibodyL-asparagine oxygenase elisa and antibody
Shop L-asparagine oxygenase ELISA Kit, Recombinant Protein and L-asparagine oxygenase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
https://www.mybiosource.com/protein_family.php?root=l-asparagine-oxygenase
CAS 160416-17-1 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-asparagine tert-butyl ester - BOC SciencesCAS 160416-17-1 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-asparagine tert-butyl ester - BOC Sciences
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L-ASPARAGINE:H2O (1,4-13C2; ALPHA-15N, 98%), Creative Peptides L-Iso-0103 - Creative PeptidesL-ASPARAGINE:H2O (1,4-13C2; ALPHA-15N, 98%), Creative Peptides L-Iso-0103 - Creative Peptides
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Stomatologia Współczesna Suplement 1/1998 - Med Tour Press Int.Stomatologia Współczesna Suplement 1/1998 - Med Tour Press Int.
Słowa kluczowe: leczenie przewlekłych zapaleń tkanek okołowierzchołkowych, preparaty wodorotlenkowapniowe. W leczeniu przewlekłych zapaleń tkanek okołowierzchołkowych istotne jest działanie bakteriobójcze oraz stworzenie warunków do reparacji uszkodzonej kości. Najbardziej skuteczną metodą terapeutyczną okazało się biomechaniczne opracowanie kanału oraz zastosowanie wkładki leczniczej z wodorotlenku wapnia. Celem pracy była własna ocena wpływu nie twardniejących preparatów wodorotlenkowapniowych (Calxyl, Biopulp) na procesy gojenia i odnowy kości w przewlekłych zapaleniach przyzębia przyszczytowego. Leczeniem objęto 96 zębów jedno- i wielokorzeniowych. Na podstawie diagnostycznych zdjęć rtg ustalono średnicę zmian zapalnych. Wyodrębniono ogniska o średnicy do 3 mm, od 3 do 6 mm i powyżej 6 mm. Wkładki lecznicze z preparatów wodorotlenkowapniowych zmieniano co 3 miesiące. Obserwacje radiologiczne przeprowadzono po 3, 6, 9 i 12 miesiącach. Ogółem na 96 ...
http://medtourpress.pl/stomatologia-wspolczesna-suplement-1-1998/
அஸ்பரஜின் - தமிழ் விக்கிப்பீடியாஅஸ்பரஜின் - தமிழ் விக்கிப்பீடியா
அஸ்பரஜின் (Asparagine) (அ) அஸ்பரமைடு [குறுக்கம்: Asn (அ) N; அஸ்பார்டிக் அமிலம் (அ) அஸ்பரஜின் அமினோ அமிலத்தை குறிக்கும் மற்றொரு குறுக்கம்: Asx or B][2] புரதங்களில் அடிப்படையாக உள்ள 20 அமினோ அமிலங்களில் ஒன்றாகும். இதனுடைய வாய்பாடு: 2HN-CO-CH2-CH(NH2)-COOH (அ) C4H8N2O3. இது ஒரு அத்தியாவசியமற்ற ஆல்ஃபா அமினோ அமிலமாகும். அஸ்பரஜின் விலங்குகளினால்/மனிதர்களால் தயாரிக்கப்படக்கூடியது. இதன் குறிமுறையன்கள்: AAU மற்றும் AAC. ...
https://ta.wikipedia.org/wiki/%E0%AE%85%E0%AE%B8%E0%AF%8D%E0%AE%AA%E0%AE%B0%E0%AE%9C%E0%AE%BF%E0%AE%A9%E0%AF%8D
toomanykiwis.comtoomanykiwis.com
Asparagine is an amino acid, which has recently been rumored to aid the spread of breast cancer. Trials on mice have shown that low-asparagine diets, combined with blocking asparagine production in the body, greatly reduced the breast cancers ability to spread.. ...
https://www.toomanykiwis.com/
A Double blind randomized phase 2 PILOT study of ERYASPASE in patients with acute lymphoblastic leukemia/lymphoma | OncologyPROA Double blind randomized phase 2 PILOT study of ERYASPASE in patients with acute lymphoblastic leukemia/lymphoma | OncologyPRO
Asparaginase is a critical agent in the treatment of ALL. This enzyme deaminates asparagine, interfering with protein synthesis and resulting in cell death as lymphoblasts are deficient in asparagine synthetase. Eryaspase is a dispersion of homologous red blood cells (RBCs) encapsulating L-asparaginase formulated in a preservative solution for infusion. The formulation of eryaspase has evolved during its development. Two sources of L-asparaginase (drug substance) from Medac GmbH can be used as raw material and encapsulated in the RBCs: native (Kidrolase®) or recombinant L-asparaginase (Spectrila®). This study is designed to investigate the PK comparability of both eryaspase formulations: native or recombinant asparaginase as the starting material, when administered as monotherapy and in combination with chemotherapy during induction and consolidation phases for the treatment of children and young adults presenting with ALL/LBL. ...
http://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/A-Double-blind-randomized-phase-2-PILOT-study-of-ERYASPASE-in-patients-with-acute-lymphoblastic-leukemia-lymphoma
Foodista | Recipes, Cooking Tips, and Food News | Asparagine Amino AcidFoodista | Recipes, Cooking Tips, and Food News | Asparagine Amino Acid
Translations: Asparagīna Amino Acid, Asparaginas aminorūgšties, Asparagina aminoacizi, Asparagin Aminokiselinska, Amino Acid Asparagine, Asparaginy aminokwasów, Asparagine एमिनो एसिड, Aminoácido asparagina, Аспарагин Аминокислоты, Ασπαραγίνη Αμινοξύ, الهليونين الأحماض الأمينية, 아스파라긴 아미노산, Asparagin aminokyselin, Asparagina Asam Amino, Asparagine Amino acid, 天冬酰胺氨基酸, Asparagina Aminoàcids, Asparagin Amino Acid, Asparagín aminokyselín, Amminoacido asparagina, אספרגין חומצה אמינו, Asparagin Amino Acid, Аспарагин амино киселина, アスパラギンアミノ酸, Acide aminé asparagine, Asparagin Amino Acid, Asparagin Amino Acid, Asparaginer Amino Acid, Asparagina Aminoácidos, Аспарагін Амінокислоти, Asparagiini Aminohappo, Аспарагин амино ...
http://www.foodista.com/food/HS2S3ND5/asparagine-amino-acid
Matthew Patrick - Island Soul - GuestbookMatthew Patrick - Island Soul - Guestbook
Najem samochodów dostawczych w Warszawie jakkolwiek usługa idealnie skrojona na ilość potrzeb współczesnego Konsumenta! Stolica jest stroną, w jakiej idzie relatywnie sporo wypożyczalni wypożyczalnia aut dostawczych warszawa (click https://hellogoodbyethankyou.tumblr.com/), natomiast ich mężczyznami są nie tylko przybywający tu w handlach biznesmeni, jakkolwiek dodatkowo zwykli obywatele Najważniejszym mieście, jacy wymagają samochodu naprawdę rzadko, iż nie finansuje im się umieć go na cecha - po prostu w razie sprawy go wynajmują. Jesteśmy skupieni na nowoczesnym, aby dać Państwu kompletne szczęście - niezależnie od aktualnego, lub potrzebują Państwo zdecydować się na wynajem krótkoterminowy, średnioterminowy albo i długoterminowy, własna oferta zawsze stanowi efektywna a będzie ekskluzywnym wsparciem niezależnie z robionej poprzez Państwa działalności. Interes prowadzi także możliwość rezerwacji telefonicznej, i swej w lokalnej wypożyczalni ...
http://matthewpatrickfeuer.com/guestbook.html
Tumor - OrthopaedicsOne Articles - OrthopaedicsOneTumor - OrthopaedicsOne Articles - OrthopaedicsOne
Browse Articles by Topic Tumor Chart - Summary table of the seven questions to ask, differential diagnosis and important information about each tumor. Musculoskeletal tumors - The five presenting complaints Soft tissue mass Painless bony mass Bone
https://www.orthopaedicsone.com/display/Main/Tumor?atl_token=dba6d0bc6482a0790b4b1af3d6b82f6a966d4e7c
The glycemic, insulinemic and plasma amino acid responses to equi-carbohydrate milk meals, a pilot- study of bovine and human...The glycemic, insulinemic and plasma amino acid responses to equi-carbohydrate milk meals, a pilot- study of bovine and human...
Dairy proteins, in particular the whey fraction, exert insulinogenic properties and facilitate glycemic regulation through a mechanism involving elevation of certain plasma amino acids, and stimulation of incretins. Human milk is rich in whey protein and has not been investigated in this respect ...
http://www.forskningsdatabasen.dk/catalog/234128610
BYU ScholarsArchive - 9th International Congress on Environmental Modelling and Software: Spatial and dynamic sensitivity...BYU ScholarsArchive - 9th International Congress on Environmental Modelling and Software: Spatial and dynamic sensitivity...
Modelling complex systems such as agroecosystems often requires the quantification of a large number of input factors. Sensitivity analyses are useful to fix the appropriate spatial and temporal resolution of models and to reduce the number of input factors to be measured or estimated accurately. Comprehensive spatial and dynamic sensitivity analyses were applied to the Nitroscape model, a deterministic spatially distributed model describing nitrogen transfers and transformations in a rural landscape. Simulations were led on a virtual landscape that represented five years of farm management in an intensive rural area of 3 km². Cluster analyses were applied to summarize the results of the sensitivity analysis on the ensemble of model outcomes. The 29 studied output variables were split into five different clusters that grouped outcomes with similar response to input factors. Among the 11 studied factors, model outcomes were mainly sensitive to inputs characterizing the lateral transmissivity of soil.
https://scholarsarchive.byu.edu/iemssconference/2016/Stream-B/30/
IGF Receptors - BET-bromodomain inhibition researchIGF Receptors - BET-bromodomain inhibition research
Data Availability StatementThe following amino acid sequences from the catalytic area of individual proteins kinases were useful for the phylogenetic tree structure: AMPK(accession zero. Hector et al. 2016 [29]), zebrafish CDKL5 (accession no. type:entrez-protein,attrs:text:NP_001124243.1″,term_id:195546828″,term_text:NP_001124243.1″NP_001124243.1), and individual ERK2 (accession zero. type:entrez-protein,attrs:text:NP_002736.3″,term_id:66932916″,term_text:NP_002736.3″NP_002736.3). Abstract Cyclin-dependent kinase-like 5 (CDKL5, also called STK9) is certainly a serine/threonine proteins kinase originally determined in 1998 throughout a transcriptional mapping task from the individual X chromosome. Thereafter, a mutation in was reported in people with the atypical Rett syndrome, a neurodevelopmental disorder, suggesting that CDKL5 plays an important regulatory role in neuronal function. The disease associated with mutation has recently been recognised as ...
http://healthandwellnesssource.org/category/igf-receptors/
Plus itPlus it
Synthesis and expression of cDNA encoding chimeric and mutated subunits. cDNA constructs for human α4 (Kuryatov et al., 1997) and β2 (Anand and Lindstrom, 1990) subunits were kindly provided by Dr. Jon Lindstrom (University of Pennsylvania, Philadelphia, PA) in pSP64 and were transferred to pcDNA3 (Invitrogen, Carlsbad, CA) for use. Rat α4 and β2 subunits were kindly provided by Dr. J. Patrick (Baylor College of Medicine, Houston, TX) (Sabey et al., 1999). Because of the high homology between the rat and human subunits, identical restriction sites could be found for the production of chimeras. Three sets of chimeric α4 subunits were made; for each set, one chimera was made with the rat sequence from the N terminus to the chimeric join, whereas the other chimera was made with the human sequence at the N terminus. The chimera pairs were made at the following amino acid residues (numbered for the mature protein): X1, 131/132 (AatII); X2, 296/297 (Alw44I); and X3, rat 268/human 268 or human ...
http://www.jneurosci.org/content/21/17/6561
Download Hindsight: The Promise And Peril Of Looking Backward 2009Download Hindsight: The Promise And Peril Of Looking Backward 2009
We often did the download Hindsight: The Promise and Peril of of fall series clustering people. The sociolinguistics are that most of the retribution forms had same as to cause as modeling estimates for Mapping external modulational aphorisms. Varada Kolhatkar and Heike Zinsmeister and Graeme Hirst, Persian of the 2013 blessing on unsuitable theories in Natural Language Processing( EMNLP-2013), Geography 300--310, October, Seattle AbstractInterpreting Popular transcriptome farmers( ASNs) generic as this something and this fun is stylistic to building physically any standardized memorable head set. One novel in sequencing events for forward according ASNs is the action of Taken years. explain more about references also. The presentation, domain; Tributaries, rejects the loopholes of report, problem and distinction, techniques of basic thinking. biblical fortifications of First Nations demarcation know a tuber; authenticity, policy and pp. through majority, style and speech worked by red elite, ...
http://theorganizedone.com/new/library/download-Hindsight%3A-The-Promise-and-Peril-of-Looking-Backward-2009.php
Plus itPlus it
The mechanism by which asparaginase inhibits the 6C3HED tumor is probably not directly related to the cellular concentration of asparagine, since the concentration of asparagine decreases in resistant tumors, spleen, and liver, as well as in susceptible tumors. Amino acids other than asparagine may be affected by asparaginase because of the variety of metabolic relationships of the amino acids. In this study, analyses of all the amino acids of resistant 6C3HED tumor, susceptible 6C3HED tumor, spleen, and liver were undertaken.. Most of the amino acids of the susceptible tumor increased from 2- to 40-fold, while only slight changes occurred in the resistant tumor. The most dramatic change was a decrease in glycine in the susceptible tumor. No parallel change in glycine occurred in the resistant tumor, the spleen, or the liver. It is suggested that the susceptible tumor may synthesize glycine from asparagine; consequently, the decrease in asparagine is followed by a decrease in cellular glycine. ...
http://cancerres.aacrjournals.org/content/30/4/1206
Role of Insulin, Adipocyte Hormones, and Nutrient-Sensing Pathways in Regulating Fuel Metabolism and Energy Homeostasis: A...Role of Insulin, Adipocyte Hormones, and Nutrient-Sensing Pathways in Regulating Fuel Metabolism and Energy Homeostasis: A...
Thank you for your interest in spreading the word about Science Signaling.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://stke.sciencemag.org/content/2006/346/re7/tab-article-info
Suchergebnis: Tommassen, J..Suchergebnis: Tommassen, J..
Summary The pepN gene has been cloned into the multicopy plasmid pBR322. The restriction map of the insert was established and the gene was localized. By comparison with the restriction map of the plasmid pJP30 bearing the ompF region, it has been possible to order the ompF, asnS, and pepN genes.... mehr ...
http://finden.nationallizenzen.de/Search/Results?lookfor=Tommassen%2C%20J..&type=Author
Table of Contents - July 01, 1963, 118 (1) | JEMTable of Contents - July 01, 1963, 118 (1) | JEM
II. LYMPHOMA 6C3HED CELLS CULTURED IN A MEDIUM DEVOID OF L-ASPARAGINE LOSE THEIR SUSCEPTIBILITY TO THE EFFECTS OF GUINEA PIG SERUM IN VIVO ...
http://jem.rupress.org/content/118/1
Asparaginase - SorachimAsparaginase - Sorachim
Asparaginasefrom Escherichia coliL-Asparagine amidohydrolaseEC # 3.5.1.1If you need bigger quantities than indicated on the web site, please contact us for a personal offer.
http://www.sorachim.com/enzymes/asparaginase.html
Asparagine synthetaseAsparagine synthetase
... (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate. ... This domain is responsible for the binding of both Mg2+ATP and aspartate. These two active sites are connected by a tunnel ... The human glutamine-dependent AS is encoded by a single gene located in region q21.3 on chromosome 7. The lack of ammonia- ... Thus, after being released in, and channeled from, the glutaminase site, the ammonia molecule attacks the bound βAspAMP 1 to ...
https://en.wikipedia.org/wiki/Asparagine_synthetase
List of MeSH codes (D08)List of MeSH codes (D08)
... aspartate-ammonia ligase MeSH D08.811.464.259.200.600 --- glutamate-ammonia ligase MeSH D08.811.464.259.300 --- ... ammonia-lyases MeSH D08.811.520.232.400.200 --- aspartate ammonia-lyase MeSH D08.811.520.232.400.350 --- ethanolamine ammonia- ... alanine-tRNA ligase MeSH D08.811.464.263.200.100 --- arginine-tRNA ligase MeSH D08.811.464.263.200.150 --- aspartate-tRNA ... tyrosine-tRNA ligase MeSH D08.811.464.263.200.950 --- valine-tRNA ligase MeSH D08.811.464.267.500 --- coenzyme a ligases MeSH ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
Aspartate-ammonia ligaseAspartate-ammonia ligase
In enzymology, an aspartate-ammonia ligase (EC 6.3.1.1) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (AMP-forming). Other names in ... This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... Webster GC & Varner JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems". J. Biol. Chem. 215: 91-99. ...
https://en.wikipedia.org/wiki/Aspartate—ammonia_ligase
D-aspartate ligaseD-aspartate ligase
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... In enzymology, a D-aspartate ligase (EC 6.3.1.12) is an enzyme that catalyzes the chemical reaction ATP + D-aspartate + [beta- ... n ligase (ADP-forming). Other names in common use include Aslfm, UDP-MurNAc-pentapeptide:D-aspartate ligase, and D-aspartic ... Heijenoort J, Legrand R, Brouard JP, Rice L, Mainardi JL (2006). "Aslfm, the D-aspartate ligase responsible for the addition of ...
https://en.wikipedia.org/wiki/D-aspartate_ligase
Aspartate-ammonia ligase (ADP-forming)Aspartate-ammonia ligase (ADP-forming)
... an aspartate-ammonia ligase (ADP-forming) (EC 6.3.1.4) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (ADP-forming). Other names in ... This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine. ...
https://en.wikipedia.org/wiki/Aspartate—ammonia_ligase_(ADP-forming)
List of EC numbers (EC 6)List of EC numbers (EC 6)
... aspartate-ammonia ligase EC 6.3.1.2: glutamate-ammonia ligase EC 6.3.1.3: Now EC 6.3.4.13 EC 6.3.1.4: aspartate-ammonia ligase ... valine-tRNA ligase EC 6.1.1.10: methionine-tRNA ligase EC 6.1.1.11: serine-tRNA ligase EC 6.1.1.12: aspartate-tRNA ligase EC ... histidine-tRNA ligase EC 6.1.1.22: asparagine-tRNA ligase EC 6.1.1.23: aspartate-tRNAAsn ligase EC 6.1.1.24: glutamate-tRNAGln ... diphthine-ammonia ligase EC 6.3.2.1: pantoate-b-alanine ligase EC 6.3.2.2: glutamate-cysteine ligase EC 6.3.2.3: glutathione ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_6)
BiosynthesisBiosynthesis
... asparagine synthetase catalyzes the addition of nitrogen from glutamine or soluble ammonia to aspartate to yield asparagine. ... Okazaki fragments are covalently joined by DNA ligase to form a continuous strand. Then, to complete DNA replication, RNA ... The biosynthesis of aspartate is a one step reaction that is catalyzed by a single enzyme. The enzyme aspartate ... The aspartate family of amino acids includes: threonine, lysine, methionine, isoleucine, and aspartate. Lysine and isoleucine ...
https://en.wikipedia.org/wiki/Biosynthesis
List of EC numbers (EC 4)List of EC numbers (EC 4)
... aspartate ammonia-lyase EC 4.3.1.2: methylaspartate ammonia-lyase EC 4.3.1.3: histidine ammonia-lyase EC 4.3.1.4: ... heme ligase "Enzyme: 4.1.2.8". Kyoto Encyclopedia of Genes and Genomes. Retrieved 2017-04-07. European Bioinformatics Institute ... b-alanyl-CoA ammonia-lyase EC 4.3.1.7: ethanolamine ammonia-lyase EC 4.3.1.8: now EC 2.5.1.61 EC 4.3.1.9: glucosaminate ammonia ... threo-3-hydroxyaspartate ammonia-lyase EC 4.3.1.17: L-serine ammonia-lyase EC 4.3.1.18: D-serine ammonia-lyase EC 4.3.1.19: ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_4)
List of EC numbers (EC 2)List of EC numbers (EC 2)
... glutamate-ammonia-ligase) adenylyltransferase EC 2.7.7.43: N-acylneuraminate cytidylyltransferase EC 2.7.7.44: glucuronate-1- ... aspartate kinase EC 2.7.2.5: now EC 6.3.4.16 EC 2.7.2.6: formate kinase EC 2.7.2.7: butyrate kinase EC 2.7.2.8: acetylglutamate ... ammonia kinase EC 2.7.3.9: Phosphoenolpyruvate-protein phosphotransferase EC 2.7.3.10: agmatine kinase EC 2.7.3.11: now EC 2.7. ... aspartate transaminase EC 2.6.1.2: alanine transaminase EC 2.6.1.3: cysteine transaminase EC 2.6.1.4: glycine transaminase EC ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_2)
List of enzymesList of enzymes
EC 2.6.1 Alanine transaminase EC 2.6.1.2 Aspartate transaminase EC 2.6.1.1 Category:EC 2.7.2 Butyrate kinase (EC 2.7.2.7) ... EC 4.3.1 Phenylalanine ammonia-lyase (EC 4.3.1.24) Category:EC 4.4.1 Cystathionine gamma-lyase Cystathionine beta-lyase ... DNA ligase (EC 6.5.1.1). ...
https://en.wikipedia.org/wiki/List_of_enzymes
AmphetamineAmphetamine
CYP2D6, dopamine β-hydroxylase (DBH), flavin-containing monooxygenase 3 (FMO3), butyrate-CoA ligase (XM-ligase), and glycine N- ... The review indicated that magnesium L-aspartate and magnesium chloride produce significant changes in addictive behavior; other ... Another method is the reaction of phenylacetone with ammonia, producing an imine intermediate that is reduced to the primary ... This reaction is catalyzed by the HXM-A and HXM-B medium-chain acid:CoA ligases and requires energy in the form of ATP. ... The ...
https://en.wikipedia.org/wiki/Amphetamine
Carbamoyl phosphate synthetaseCarbamoyl phosphate synthetase
Carboxy phosphate reacts with ammonia to give carbamic acid. In turn, carbamic acid reacts with a second ATP to give carbamoyl ... Aspartate. *Cysteine. *D-alanine-poly(phosphoribitol) ligase. *Glutamate. *Glutamine. *Glycine. *Histidine. *Isoleucine ... The small subunit contains the glutamine binding site and catalyses the hydrolysis of glutamine to glutamate and ammonia, which ... The carboxylphosphate then reacts with ammonia to form carbamic acid, releasing inorganic phosphate. ...
https://en.wikipedia.org/wiki/Carbamoyl_phosphate_synthetase
Catalytic triadCatalytic triad
In the first active site, a cysteine triad hydrolyses a glutamine substrate to release free ammonia. The ammonia then diffuses ... The aspartate is hydrogen bonded to the histidine, increasing the pKa of its imidazole nitrogen from 7 to around 12. This ... "A Designed Peptide Ligase for Total Synthesis of Ribonuclease A with Unnatural Catalytic Residues". Science. 266 (5183): 243- ... The Serine-Histidine-Aspartate motif is one of the most thoroughly characterised catalytic motifs in biochemistry. The triad is ...
https://en.wikipedia.org/wiki/Catalytic_triad
List of EC numbers (EC 3)List of EC numbers (EC 3)
... glutamate-ammonia ligase) hydrolase EC 3.1.4.16: 2',3'-cyclic-nucleotide 2'-phosphodiesterase EC 3.1.4.17: 3',5'-cyclic- ... The enzyme is not a serine protease, as thought previously, but an aspartate protease EC 3.4.21.88: Repressor LexA EC 3.4.21.89 ... N-acyl-D-aspartate deacylase EC 3.5.1.84: biuret amidohydrolase EC 3.5.1.85: (S)-N-acetyl-1-phenylethylamine hydrolase EC 3.5. ... aspartate carboxypeptidase EC 3.4.17.6: alanine carboxypeptidase EC 3.4.17.7: Transferred entry: acylmuramoyl-alanine ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_3)
KynureninaseKynureninase
... belongs to the class V group of aspartate aminotransferase superfamily of structurally homologous pyridoxal 5'- ...
https://en.wikipedia.org/wiki/Kynureninase
Creatine kinaseCreatine kinase
Glutamate aspartate transporter. *Glycerol-3-phosphate dehydrogenase. *ATP synthase. *Carnitine palmitoyltransferase II ...
https://en.wikipedia.org/wiki/Creatine_kinase
Catalytic triadCatalytic triad
... a cysteine triad hydrolyses a glutamine substrate to release free ammonia. The ammonia then diffuses though an internal tunnel ... The aspartate is hydrogen bonded to the histidine, increasing the pKa of its imidazole nitrogen from 7 to around 12. This ... 1994). "A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues". Science. 266 (5183 ... The triad consists of an aspartate (acid), histidine (base) and serine (nucleophile). The substrate (black) is bound by the ...
https://en.m.wikipedia.org/wiki/Catalytic_triad
List of enzymesList of enzymes
Category:Ligases (EC 6) (Ligase)Edit. Category:EC 6.1 (form carbon-oxygen bonds)Edit. 6-carboxytetrahydropterin synthase ... Phenylalanine ammonia-lyase (EC 4.3.1.24). Category:EC 4.4 (carbon-sulfur lyases)Edit. *Category:EC 4.4.1 *Cystathionine gamma- ... Aspartate transaminase EC 2.6.1.1. Category:EC 2.7 (transfer phosphorus-containing groups)Edit. *Category:EC 2.7.2 *Butyrate ... 6 Category:Ligases (EC 6) (Ligase) *6.1 Category:EC 6.1 (form carbon-oxygen bonds) ...
https://en.m.wikipedia.org/wiki/List_of_enzymes
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Aspartate-ammonia ligase - WikipediaAspartate-ammonia ligase - Wikipedia
In enzymology, an aspartate-ammonia ligase (EC 6.3.1.1) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (AMP-forming). Other names in ... This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... Webster GC & Varner JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems". J. Biol. Chem. 215: 91-99. ...
https://en.wikipedia.org/wiki/Aspartate%E2%80%94ammonia_ligase
Aspartate-ammonia ligase (ADP-forming) - WikipediaAspartate-ammonia ligase (ADP-forming) - Wikipedia
... an aspartate-ammonia ligase (ADP-forming) (EC 6.3.1.4) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (ADP-forming). Other names in ... This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine. ...
https://en.wikipedia.org/wiki/Aspartate%E2%80%94ammonia_ligase_(ADP-forming)
BRENDA - Information on EC 6.3.1.1 - aspartate-ammonia ligaseBRENDA - Information on EC 6.3.1.1 - aspartate-ammonia ligase
Information on EC 6.3.1.1 - aspartate-ammonia ligase. for references in articles please use BRENDA:EC6.3.1.1 ... ammonia-dependent ASNS, ammonia-dependent asparagine synthetase, AS-A, AS-AR, AsnA, ASNS, Asparagine synthetase, Asparagine ... and EC 6.3.5.4: The gene asnA codes for ammonia-dependent asparagine synthetases, EC 6.3.1.1, and the gene asnB codes for Gln- ... Alanine, aspartate and glutamate metabolism, Biosynthesis of secondary metabolites, Cyanoamino acid metabolism ...
https://brenda-enzymes.org/enzyme.php?ecno=6.3.1.1
ASNS gene: MedlinePlus GeneticsASNS gene: MedlinePlus Genetics
aspartate ammonia ligase. *glutamine-dependent asparagine synthetase. *TS11. *TS11 cell cycle control protein ... Asparagine helps to break down toxic ammonia within cells, is important for protein modification, and is needed for making a ...
https://medlineplus.gov/genetics/gene/asns/
Defective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitisDefective lysosomal clearance of autophagosomes and its clinical implications in nonalcoholic steatohepatitis
Aspartate-Ammonia Ligase / deficiency * Aspartate-Ammonia Ligase / genetics * Aspartate-Ammonia Ligase / metabolism ...
https://pubmed.ncbi.nlm.nih.gov/28842428/?dopt=Abstract
Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum |...Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum |...
In addition, the aspartate ammonia ligase gene is expressed, as evidenced by an EST. In another case, copies of a 1,4-α-glucan ... The trpB gene and the gene for aspartate ammonia ligase are located 4,881 base-pairs (bp) apart on the same strand of a contig ... The origin of aspartate ammonia ligase is eubacterial, but not definitively of any particular lineage. In the absence of genome ... Three genes - aspartate ammonia ligase, BT-1 and lactate dehydrogenase - are expressed, as confirmed by the presence of an EST ...
https://genomebiology.biomedcentral.com/articles/10.1186/gb-2004-5-11-r88
Phenotypic and Genotypic Analysis of Amino Acid Auxotrophy in Lactobacillus helveticus CNRZ 32 | Applied and Environmental...Phenotypic and Genotypic Analysis of Amino Acid Auxotrophy in Lactobacillus helveticus CNRZ 32 | Applied and Environmental...
Aspartate-ammonia ligase (EC 6.3.1.1). Incomplete. Asn or Asp. asnB Asparagine synthase (EC 6.3.5.4). ... Enzymes involved in these conversions include citrate lyase (1), aspartate aminotransferase (2), phosphoenolpyruvate ...
https://aem.asm.org/content/74/2/416/figures-only
Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera | BMC Microbiology | Full...Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera | BMC Microbiology | Full...
... an asparate ammonia ligase subunit; the CTP synthase PyrG; PrfC, a peptide chain release factor; and SP_0095, a protein with ...
https://bmcmicrobiol.biomedcentral.com/articles/10.1186/1471-2180-11-245
Comparative genome analysis of central nitrogen metabolism and its control by GlnR in the class Bacilli | BMC Genomics | Full...Comparative genome analysis of central nitrogen metabolism and its control by GlnR in the class Bacilli | BMC Genomics | Full...
... aspartate-ammonia ligase/asparagine synthetase (asnA[36] or asnB[37]), asparaginase (ansA or ansZ[38, 39]); and the transport ... encoding aspartate-ammonia ligase).. We also found a clear GlnR-binding site upstream of several genes involved in regulation, ... who argue that transport of ammonia (NH4+) should be tightly regulated to limit futile cycling by diffusion of ammonia out of ... In the case of the amtB-glnK operon (import of ammonia) it was formerly concluded that it is not repressed by GlnR on the basis ...
https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-191
Systematic search for putative new domain families in Mycoplasma gallisepticum genomeSystematic search for putative new domain families in Mycoplasma gallisepticum genome
... ammonia ligase (asparagine synthetase) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ... The crystal structure of E.coli asparagine synthetase also showed the presence of this small subdomain[16]. Aspartate-- ... ammonia. AsnA structure revealed that AsnA structure is similar to that of the catalytic domain of yeast aspartyl-tRNA ...
http://pubmedcentralcanada.ca/pmcc/articles/PMC2865477/
Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify...Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify...
... by asparagine synthase or aspartate-ammonia ligase.. Genes for fatty acid biosynthesis, such as fabG, fabA, fabZ, fabI, fabK, ... The l-asparagine pathway is absent in all the S. aureus genomes, along with the capability to convert l-aspartate to asparagine ...
https://jb.asm.org/content/191/12/4015
Frontiers | The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides ...Frontiers | The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides ...
... aspartate-ammonia ligase (K01914), glutamine synthetase (K01915), asparagine synthase (K01953), diaminopimelate epimerase ( ... On the other hand, signals for gene expression attenuation seem to affect predominantly the alanine, aspartate and glutamate ( ... alanine-aspartate-glutamate (ko:00250), phenyalanine (ko:00360), tryptophan (ko:00380), and arginine (ko:00220) metabolism. ...
https://www.frontiersin.org/articles/10.3389/fcimb.2017.00383/full
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISMKEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM
glutamate-ammonia ligase. 2805. 2805. GOT1. glutamic-oxaloacetic transaminase 1, solubl.... 2806. 2806. GOT2. glutamic- ... Gene Set: KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM. Standard name. KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM. ...
http://software.broadinstitute.org/gsea/msigdb/cards/KEGG_ALANINE_ASPARTATE_AND_GLUTAMATE_METABOLISM.html
m0 acute myelogenous leukemia drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginem0 acute myelogenous leukemia drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Aspartate-Ammonia Ligase / metabolism. Fatal Outcome. Female. Humans. Remission Induction. *Genetic Alliance. consumer health ... Aspartate-Ammonia Ligase ...
http://www.bmlsearch.com/?kwr=m0+acute+myelogenous+leukemia+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
nk cell lymphoblastic lymphoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search enginenk cell lymphoblastic lymphoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
MeSH-minor] Aspartate-Ammonia Ligase / biosynthesis. Aspartate-Ammonia Ligase / genetics. Cell Line, Tumor. Doxorubicin / ... Chemical-registry-number] 7006-34-0 / Asparagine; EC 6.3.1.1 / Aspartate-Ammonia Ligase ... Aspartate-Ammonia Ligase ...
http://www.bmlsearch.com/?kwr=nk+cell+lymphoblastic+lymphoma+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
Find Research Outputs - University of Illinois at Urbana-ChampaignFind Research Outputs - University of Illinois at Urbana-Champaign
Hong Chen - Research Output - University of Illinois at Urbana-ChampaignHong Chen - Research Output - University of Illinois at Urbana-Champaign
Aspartate-Ammonia Ligase aspartate-ammonia ligase Transcription Initiation Site Hep G2 Cells ...
https://experts.illinois.edu/en/persons/hong-chen/publications/?ordering=type&descending=false
The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life<...The exposure to uteroplacental insufficiency is associated with activation of unfolded protein response in postnatal life<...
aspartate-ammonia ligase Carrier Proteins Aspartate-Ammonia Ligase life events Genes gluconeogenesis ...
https://moh-it.pure.elsevier.com/en/publications/the-exposure-to-uteroplacental-insufficiency-is-associated-with-a
Joe Gray - Publications - Oregon Health & Science UniversityJoe Gray - Publications - Oregon Health & Science University
Wyrobek, A. J., Mulvihill, J. J., Wassom, J. S., Malling, H. V., Shelby, M. D., Lewis, S. E., Witt, K. L., Preston, R. J., Perreault, S. D., Allen, J. W., DeMarini, D. M., Woychik, R. P., Bishop, J. B., Anderson, D., Arnheim, N., Boice, J. D., Bridges, B. A., Crow, J. F., Dubrova, Y. E., Eichenlaub-Ritter, U. & 16 others, Erickson, R. P., Fridlyand, J., Gray, J., Hanawalt, P. C., Handel, M. A., Marchetti, F., Mohrenweiser, H. W., Moyzis, R. K., Primig, M., Russell, L. B., Sankaranarayanan, K., Skinner, M. K., Shoubridge, E. A., Taylor, J. A., Trasler, J. M. & Vasicek, T. J., Feb 2007, In : Environmental and Molecular Mutagenesis. 48, 2, p. 71-95 25 p.. Research output: Contribution to journal › Article ...
https://ohsu.pure.elsevier.com/en/persons/joe-gray/publications/?page=1&ordering=type&descending=false
Code System ConceptCode System Concept
Aspartate-ammonia ligase (substance). Code System Preferred Concept Name. Aspartate-ammonia ligase (substance). ... Enzyme (substance) {90668006 , SNOMED-CT } Substance with ligase mechanism of action (substance) {1672007 , SNOMED-CT } ... Aspartate-ammonia ligase Current Synonym true false 6200014 Asparagine synthetase Current Synonym true false ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=3070009
日下部 宜宏 - 研究成果 - 九州大学日下部 宜宏 - 研究成果 - 九州大学
Aspartate-Ammonia Ligase aspartate-ammonia ligase Bombyx Polycomb-Group Proteins transcriptional activation ...
https://kyushu-u.pure.elsevier.com/ja/persons/takahiro-kusakabe/publications/?ordering=publicationYearThenTitle&descending=false&page=2
Code System ConceptCode System Concept
Aspartate-ammonia ligase (adenosine diphosphate-forming) Current Synonym true false 58222010 Aspartate-ammonia ligase (ADP- ... Aspartate-ammonia ligase (adenosine diphosphate-forming) (substance). Code System Preferred Concept Name. Aspartate-ammonia ... Enzyme (substance) {90668006 , SNOMED-CT } Substance with ligase mechanism of action (substance) {1672007 , SNOMED-CT } ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=34888001
Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction<...Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction<...
Aspartate-Ammonia Ligase Chemical Compounds * Starvation Medicine & Life Sciences * Aspartic Acid Chemical Compounds ... and disrupting their malate-aspartate shuttle. Supplementation of aspartate, depletion of mitochondria, and knockdown of ASNS ... and disrupting their malate-aspartate shuttle. Supplementation of aspartate, depletion of mitochondria, and knockdown of ASNS ... and disrupting their malate-aspartate shuttle. Supplementation of aspartate, depletion of mitochondria, and knockdown of ASNS ...
https://ucdavis.pure.elsevier.com/en/publications/arginine-starvation-kills-tumor-cells-through-aspartate-exhaustio
Recombinant Human Glutamate-ammonia Ligase, His-tagged GLUL-769H - Creative BioMartRecombinant Human Glutamate-ammonia Ligase, His-tagged GLUL-769H - Creative BioMart
Alanine, aspartate and glutamate metabolism; Arginine and proline metabolism; Metabolic pathways; Nitrogen metabolism. ... GLUL glutamate-ammonia ligase [ Homo sapiens ]. Synonyms:. GLUL; glutamate-ammonia ligase; GS; GLNS; PIG43; PIG59; glutamine ... ATP binding; glutamate decarboxylase activity; glutamate-ammonia ligase activity; identical protein binding; ligase activity; ... Recombinant Human Glutamate-ammonia Ligase, His-tagged. Download Datasheet See All GLUL Products. Bring this labeled protein ...
https://www.creativebiomart.net/description_631_14.htm
RCCTM - Precision medicine - Fingerprint - Taipei Medical UniversityRCCTM - Precision medicine - Fingerprint - Taipei Medical University
Fingerprint Dive into the research topics where RCCTM - Precision medicine is active. These topic labels come from the works of this organisations members. Together they form a unique fingerprint. ...
https://tmu.pure.elsevier.com/en/organisations/rcctm-precision-medicine/fingerprints/
尋找研究成果 - 臺北醫學大學尋找研究成果 - 臺北醫學大學
In vitro SUMOylation assay to study SUMO E3 ligase activity. Yang, W. S., Campbell, M., Kung, H. J. & Chang, P. C., 一月 29 2018 ... Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction. Cheng, C. T., Qi, Y., Wang, Y ... Kaposis Sarcoma-Associated Herpesvirus K-Rta Exhibits SUMO-Targeting Ubiquitin Ligase (STUbL) Like Activity and Is Essential ...
https://tmu.pure.elsevier.com/zh/publications/?ordering=lastNameFirstName&descending=true&showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2011&publicationYear=2012&publicationYear=2013&publicationYear=2014&publicationYear=2015&publicationYear=2016&publicationYear=2017&publicationYear=2018&publicationYear=2019&publicationYear=2020&author=f25f5146-ff7c-4173-bf7e-828ca4e032a7
The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE...The sucrose regulated transcription factor bZIP11 affects amino acid metabolism by regulating the expression of ASPARAGINE...
Aspartate-Ammonia Ligase/genetics. *Aspartate-Ammonia Ligase/metabolism*. *Basic-Leucine Zipper Transcription Factors/genetics ...
https://www.ncbi.nlm.nih.gov/pubmed/18088315?dopt=Abstract
Journal: Plant physiology / Publication Year: 1997 / Subject: dose response and enzyme activity / Text Availability: Citation...Journal: Plant physiology / Publication Year: 1997 / Subject: dose response and enzyme activity / Text Availability: Citation...
... aspartate-ammonia ligase; genes; gene expression; transcription (genetics). Abstract:. ... The accumulation and reduction of ... ammonia; nitrates; cell division; ribulose-bisphosphate carboxylase; phosphoenolpyruvate carboxylase; carbonate dehydratase; ...
https://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Plant+physiology&f%5Bpublication_year_rev%5D%5B%5D=8003-1997&f%5Bsubject_term%5D%5B%5D=dose+response&f%5Bsubject_term%5D%5B%5D=enzyme+activity&f%5Btext_availability%5D%5B%5D=Citation+in+PubAg
Journal: Plant physiology / Publication Year: 1997 / Source: 1997 v.114 no.2 - PubAg Search ResultsJournal: Plant physiology / Publication Year: 1997 / Source: 1997 v.114 no.2 - PubAg Search Results
... aspartate-ammonia ligase; genes; gene expression; transcription (genetics). Abstract:. ... The accumulation and reduction of ... Zea mays; succinic acid; enzyme inhibitors; ligases; pH; kinetics; enzyme activity; chemical structure; protein composition. ...
https://pubag.nal.usda.gov/?f%5Bjournal_name%5D%5B%5D=Plant+physiology&f%5Bpublication_year_rev%5D%5B%5D=8003-1997&f%5Bsource%5D%5B%5D=1997+v.114+no.2&per_page=50
ECMDB: ProteinsECMDB: Proteins
Aspartate--ammonia ligase. Enzyme. L-Aspartic acid. Adenosine triphosphate. Ammonium. Adenosine monophosphate. L-Asparagine. ...
http://ecmdb.ca/proteins?page=3
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth CareGeographicals
LeuconostocaceaeLactobacillalesGlutamate DehydrogenaseGenomicsSodium-Hydrogen AntiporterMolecular Sequence DataGenome, BacterialMycoplasma gallisepticumArchivesMycoplasmaBiological Science DisciplinesPeriodicals as TopicPubMedDirectories as TopicBacteroidesBacteroides fragilisBacteroides InfectionsPrevotellaTetracycline ResistanceConjugation, GeneticR FactorsReceptors, LipoproteinLipoproteins, HDLADP-ribosyl CyclaseSearch EngineLipoproteins, LDLLipoproteinsReceptors, LDLOregonCrowsBibliometricsPublicationsState Health PlansPublishingArgininosuccinate SynthaseArginineArgininosuccinate LyaseCitrullineArginaseCell Line, TumorEquidaeIndividualized MedicineHealth Maintenance OrganizationsDermatoglyphicsDNA FingerprintingTaiwanResearchDivingCanadaMetabolomicsBritish ColumbiaAlbertaAcademies and InstitutesMetabolome
AminotransferaseAlanineGLULProteinTransaminaseMitochondrialAmideCarbamoyl-phosphateEnzymesStarvationNitrogenTRNASynthetaseLyaseAccumulation of ammoniaGlutamate DehydrogenaseArginineASNSGOT1CitrullineToxicMolecularReaction
Aminotransferase5
  • See Aspartame , Aspartate aminotransferase . (thefreedictionary.com)
  • Aspartate aminotransferase-immunoglobulin complexes in patients with chronic liver disease. (thefreedictionary.com)
  • An immunological procedure for determination of mitochondrial aspartate aminotransferase in human serum. (thefreedictionary.com)
  • Immunoglobulin-complexed aspartate aminotransferase. (thefreedictionary.com)
  • 2. During inflammation, neuronal cell bodies have a biphasic temporal alteration in production of glutaminase (GLS1) and cytosolic aspartate aminotransferase (cAST), enzymes for Glu synthesis. (okstate.edu)
Alanine1
GLUL5
  • GLUL catalyzes the synthesis of glutamine from glutamate and ammonia. (creativebiomart.net)
  • GLUL is essential for proliferation of fetal skin fibroblasts and plays an important role in controlling body pH by removing ammonia from circulation. (creativebiomart.net)
  • Homo sapiens glutamate-ammonia ligase (glutamine synthetase) (GLUL), transcript variant 2, mRNA. (abnova.com)
  • Glutamine synthetase (EC 6.3.1.2), also called glutamate-ammonia ligase (GLUL), is expressed throughout the body and plays an important role in controlling body pH and in removing ammonia from the circulation. (abnova.com)
  • Background: Glutamate-ammonia ligase (GLUL), also known as glutamine synthetase (GS), catalyzes the de novo synthesis of glutamine from glutamate and ammonia. (cellsignal.com)
Protein5
  • Asparagine helps to break down toxic ammonia within cells, is important for protein modification, and is needed for making a certain molecule that transmits signals in the brain (a neurotransmitter). (medlineplus.gov)
  • This step combines two protein building blocks (amino acids), citrulline and aspartate, to form a molecule called argininosuccinic acid. (medlineplus.gov)
  • Below are the list of possible Aspartate, glycine, lysine and serine-rich protein products. (mybiosource.com)
  • Using sensitive sequence analysis methods we show that PafA, the protein required for pupylation, belongs to the glutamine synthetase fold and predict that it is likely to catalyze an ATP-dependent peptide ligase reaction. (biomedcentral.com)
  • Here, we report the three-dimensional structure of a site-directed mutant protein of carbamoyl phosphate synthetase from E. coli, where Cys 248 in the small subunit was changed to an aspartate. (elsevier.com)
Transaminase2
  • Background: Glutamate oxaloacetate transaminase 1 (GOT1) catalyzes the interconversion of aspartate and oxaloacetate (1). (cellsignal.com)
  • Among those patients who have AMA antibodies and alkaline phosphatase levels that are less than 1.5 times normal values, primary biliary cirrhosis may be diagnosed with 55% accuracy if patients have aspartate transaminase levels that are more than 5 times the upper limit of normal. (thefreedictionary.com)
Mitochondrial2
  • Supplementation of aspartate, depletion of mitochondria, and knockdown of ASNS all protect the arginine-starved cells, establishing the causal effects of aspartate depletion and mitochondrial dysfunction on the arginine starvation-induced cell death. (elsevier.com)
  • Ann, David K. / Arginine starvation kills tumor cells through aspartate exhaustion and mitochondrial dysfunction . (elsevier.com)
Amide1
Carbamoyl-phosphate2
  • carbamoyl-phosphate synthetase 2, aspartate. (broadinstitute.org)
  • Carbamoyl phosphate synthetase catalyzes the ATP-dependent synthesis of carbamoyl phosphate from glutamine ( EC 6.3.5.5 ) or ammonia ( EC 6.3.4.16 ) and bicarbonate. (wikipedia.org)
Enzymes1
  • Hence, we predict that PafA is the Pup ligase, which catalyzes the ATP-dependent ligation of the terminal γ-carboxylate of glutamate to lysines, similar to the above enzymes. (biomedcentral.com)
Starvation1
  • Mechanistically, arginine starvation induces asparagine synthetase (ASNS), depleting these cancer cells of aspartate, and disrupting their malate-aspartate shuttle. (elsevier.com)
Nitrogen2
  • Our analyses imply GlnR-mediated regulation in constraining the import of ammonia/amino-containing compounds and the production of intracellular ammonia under conditions of high nitrogen availability. (biomedcentral.com)
  • As a result, nitrogen (in the form of ammonia) and other byproducts of the urea cycle (such as citrulline) build up in the bloodstream. (medlineplus.gov)
TRNA1
  • This property describes a single polypeptide chain tRNA ligase responsible for direct aminoacylation with Asn. (jcvi.org)
Synthetase1
  • In the asparagine synthetase reaction, ATP is used to activate aspartate, forming beta-aspartyl-AMP. (hmdb.ca)
Lyase1
Accumulation of ammonia2
  • An accumulation of ammonia during the first few days of life leads to poor feeding, vomiting, seizures, and the other signs and symptoms of type I citrullinemia. (medlineplus.gov)
  • 12 An urea cycle disorder that involves the accumulation of ammonia in the blood. (malacards.org)
Glutamate Dehydrogenase1
  • In addition less-conserved associations were found with, for instance, glutamate dehydrogenase in Streptococcaceae, purine catabolism and the reduction of nitrite in Bacillaceae, and aspartate/asparagine deamination in Lactobacillaceae. (biomedcentral.com)
Arginine1
  • The first clinical trial to report successful treatment of erectile dysfunction with Pycnogenol[R] and L-arginine aspartate involved 40 men between 25 and 45 years of age suffering from mild ED. (thefreedictionary.com)
ASNS1
  • Our data challenge the view that ASNS promotes homeostasis, arguing instead that ASNS-induced aspartate depletion promotes cytotoxicity, which can be exploited for anti-cancer therapies. (elsevier.com)
GOT11
  • In addition, GOT1 is critical to the survival of cells with electron transport chain inhibition by generating aspartate, a metabolite determining the proliferation of these cells (3-4). (cellsignal.com)
Citrulline1
  • N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1. (abcam.com)
Toxic2
  • Ammonia is toxic, particularly to the nervous system. (medlineplus.gov)
  • 25 Citrullinemia is an inherited disorder that causes ammonia and other toxic substances to accumulate in the blood. (malacards.org)
Molecular1
  • [8] CPSase heterodimers from Escherichia coli contain two molecular tunnels: an ammonia tunnel and a carbamate tunnel. (wikipedia.org)
Reaction1
  • These inter-domain tunnels connect the three distinct active sites, and function as conduits for the transport of unstable reaction intermediates (ammonia and carbamate) between successive active sites . (wikipedia.org)
ASNS gene: MedlinePlus Genetics
ASNS gene: MedlinePlus Genetics (medlineplus.gov)
BRENDA - Information on EC 6.3.1.1 - aspartate-ammonia ligase
BRENDA - Information on EC 6.3.1.1 - aspartate-ammonia ligase (brenda-enzymes.org)
Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum |...
Phylogenomic evidence supports past endosymbiosis, intracellular and horizontal gene transfer in Cryptosporidium parvum |... (genomebiology.biomedcentral.com)
Phenotypic and Genotypic Analysis of Amino Acid Auxotrophy in Lactobacillus helveticus CNRZ 32 | Applied and Environmental...
Phenotypic and Genotypic Analysis of Amino Acid Auxotrophy in Lactobacillus helveticus CNRZ 32 | Applied and Environmental... (aem.asm.org)
Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera | BMC Microbiology | Full...
Biofilm and planktonic pneumococci demonstrate disparate immunoreactivity to human convalescent sera | BMC Microbiology | Full... (bmcmicrobiol.biomedcentral.com)
Comparative genome analysis of central nitrogen metabolism and its control by GlnR in the class Bacilli | BMC Genomics | Full...
Comparative genome analysis of central nitrogen metabolism and its control by GlnR in the class Bacilli | BMC Genomics | Full... (bmcgenomics.biomedcentral.com)
Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify...
Comparative Genome-Scale Metabolic Reconstruction and Flux Balance Analysis of Multiple Staphylococcus aureus Genomes Identify... (jb.asm.org)
Frontiers | The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides ...
Frontiers | The Glycolytic Versatility of Bacteroides uniformis CECT 7771 and Its Genome Response to Oligo and Polysaccharides ... (frontiersin.org)
Nk cell lymphoblastic lymphoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
Nk cell lymphoblastic lymphoma drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine (bmlsearch.com)
Find Research Outputs - University of Illinois at Urbana-Champaign
Find Research Outputs - University of Illinois at Urbana-Champaign (experts.illinois.edu)
Joe Gray - Publications - Oregon Health & Science University
Joe Gray - Publications - Oregon Health & Science University (ohsu.pure.elsevier.com)
日下部 宜宏 - 研究成果 - 九州大学
日下部 宜宏 - 研究成果 - 九州大学 (kyushu-u.pure.elsevier.com)
WikiGenes - GLUL - glutamate-ammonia ligase
WikiGenes - GLUL - glutamate-ammonia ligase (wikigenes.org)
ECMDB: Proteins
ECMDB: Proteins (ecmdb.ca)
Pham, N. T.<...
Pham, N. T.<... (research.ed.ac.uk)
Yun-Ru Liu - 研究成果 - 臺北醫學大學
Yun-Ru Liu - 研究成果 - 臺北醫學大學 (tmu.pure.elsevier.com)
Analysis of gene profiles involved in the enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by...
Analysis of gene profiles involved in the enhancement of all-trans retinoic acid-induced HL-60 cell differentiation by... (koreauniv.pure.elsevier.com)
JG24_15015 protein (Klebsiella pneumoniae) - STRING interaction network
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Dynamic changes of yak (Bos grunniens) gut microbiota during growth revealed by polymerase chain reaction-denaturing gradient...
Dynamic changes of yak (Bos grunniens) gut microbiota during growth revealed by polymerase chain reaction-denaturing gradient... (ajas.info)
A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors | BMC Systems Biology |...
A curated C. difficile strain 630 metabolic network: prediction of essential targets and inhibitors | BMC Systems Biology |... (bmcsystbiol.biomedcentral.com.live.oscarjournals.springer.com)
Functional gene arrays-based analysis of fecal microbiomes in patients with liver cirrhosis | BMC Genomics | Full Text
Functional gene arrays-based analysis of fecal microbiomes in patients with liver cirrhosis | BMC Genomics | Full Text (bmcgenomics.biomedcentral.com)
Plus it
Plus it (plantphysiol.org)
Evaluation of protein pattern changes in roots and leaves of Zea maysplants in response to nitrate availability by two...
Evaluation of protein pattern changes in roots and leaves of Zea maysplants in response to nitrate availability by two... (bmcplantbiol.biomedcentral.com)
Find Research outputs - UTMB Health Research Expert Profiles
Find Research outputs - UTMB Health Research Expert Profiles (researchexperts.utmb.edu)
The Use of Modified BFM +/- Compound 506U78 (Nelarabine) (NSC# 686673, IND #52611) in an Intensive Chemotherapy Regimen for the...
The Use of Modified BFM +/- Compound 506U78 (Nelarabine) (NSC# 686673, IND #52611) in an Intensive Chemotherapy Regimen for the... (adisinsight.springer.com)
Unraveling the biochemistry and provenance of pupylation: a prokaryotic analog of ubiquitination | Biology Direct | Full Text
Unraveling the biochemistry and provenance of pupylation: a prokaryotic analog of ubiquitination | Biology Direct | Full Text (biologydirect.biomedcentral.com)
Mutagenesis Manipulation of L-asparaginase
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Enzymatic Activity and pH Buffers - ScienceAid
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Almost all about citrulline in mammals | SpringerLink
Almost all about citrulline in mammals | SpringerLink (link.springer.com)
Network Portal - Gene Cj0439
Network Portal - Gene Cj0439 (networks.systemsbiology.net)