OrganismsChemicals and DrugsPhenomena and ProcessesHealth Care
Glutamate-Ammonia LigaseAspartate Ammonia-LyaseAmmoniaAspartate AminotransferasesAspartate CarbamoyltransferaseRNA Ligase (ATP)Aspartic AcidUbiquitin-Protein LigasesDNA LigasesClostridium thermocellumRenewable EnergyBiofuelsClostridiumCellulaseGram-Positive Asporogenous Rods, IrregularMetabolic Networks and Pathways
Glutamate-Ammonia Ligase
An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and L-glutamine. It also acts more slowly on 4-methylene-L-glutamate. (From Enzyme Nomenclature, 1992) EC 6.3.1.2.
Aspartate Ammonia-Lyase
An enzyme that catalyzes the conversion of aspartic acid to ammonia and fumaric acid in plants and some microorganisms. EC 4.3.1.1.
Ammonia
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
Aspartate Aminotransferases
Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
Aspartate Carbamoyltransferase
An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
RNA Ligase (ATP)
An enzyme that catalyzes the conversion of linear RNA to a circular form by the transfer of the 5'-phosphate to the 3'-hydroxyl terminus. It also catalyzes the covalent joining of two polyribonucleotides in phosphodiester linkage. EC 6.5.1.3.
Aspartic Acid
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
Ubiquitin-Protein Ligases
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
DNA Ligases
Poly(deoxyribonucleotide):poly(deoxyribonucleotide)ligases. Enzymes that catalyze the joining of preformed deoxyribonucleotides in phosphodiester linkage during genetic processes during repair of a single-stranded break in duplex DNA. The class includes both EC 6.5.1.1 (ATP) and EC 6.5.1.2 (NAD).
Clostridium thermocellum
A species of gram-positive, thermophilic, cellulolytic bacteria in the family Clostridaceae. It degrades and ferments CELLOBIOSE and CELLULOSE to ETHANOL in the CELLULOSOME.
Renewable Energy
Forms of energy that are constantly and rapidly renewed by natural processes such as solar, ocean wave, and wind energy. (from McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Biofuels
Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).
Clostridium
A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.
Cellulase
An endocellulase with specificity for the hydrolysis of 1,4-beta-glucosidic linkages in CELLULOSE, lichenin, and cereal beta-glucans.
Gram-Positive Asporogenous Rods, Irregular
A group of irregular rod-shaped bacteria that stain gram-positive and do not produce endospores.
Metabolic Networks and Pathways
Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.

L-Asparagine synthetase in serum as a marker for neoplasia. (1/128)

L-Asparagine synthetase appears in serum approximately 7 days after the s.c. implantation of 1 X 10(5) cells of Leukemia 5178Y/AR (resistant to L-asparaginase) and increases in activity as the neoplasm grows and metastasizes. The principal source of the enzyme is the primary tumor. After intravranial inoculation of tumor, the rate of leakage of the enzyme is more pronounced than when the subcutaneous, intramuscular, or intraperitoneal routes are used. 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea (NSC 79037), a nitro-sourea effective in the palliation of L5178Y/AR, temporarily halts the influx of enzyme into the blood stream, as does surgical excision of the s.c. tumor nodules. Treatment of mice with L-asparaginase within 24 hr of inoculation of the tumor markedly augments both tumor growth and the rate of penetration of L-asparagine synthetase into the circulation. Several other L-asparagine synthetase into the circulation. Several other L-asparaginase-resistant tumors also were found to spill L-asparagine synthetase into the serum, but the correlation between this phenomenon and the specific activity of the enzyme in homogenates of the tumor was imperfect.  (+info)

Transcriptional regulation of the human asparagine synthetase gene by carbohydrate availability. (2/128)

Transcription of the asparagine synthetase (AS) gene is induced by amino acid deprivation. The present data illustrate that this gene is also under transcriptional control by carbohydrate availability. Incubation of human HepG2 hepatoma cells in glucose-free medium resulted in an increased AS mRNA content, reaching a maximum of about 14-fold over control cells after approx. 12 h. Extracellular glucose caused the repression of the content of AS mRNA in a concentration-dependent manner, with a k1/2 (concentration causing a half-maximal repression) of 1 mM. Fructose, galactose, mannose, 2-deoxyglucose and xylitol were found to maintain the mRNA content of both AS and the glucose-regulated protein GRP78 in a state of repression, whereas 3-O-methylglucose did not. Incubation in either histidine-free or glucose-free medium also resulted in adaptive regulation of the AS gene in BNL-CL.2 mouse hepatocytes, rat C6 glioma cells and human MOLT4 lymphocytes, in addition to HepG2 cells. In contrast, the steady-state mRNA content of GRP78 was unaffected by amino acid availability. Transient transfection assays using a reporter gene construct documented that glucose deprivation increases AS gene transcription via elements within the proximal 3 kbp of the AS promoter. These results illustrate that human AS gene transcription is induced following glucose limitation of the cells.  (+info)

RT-PCR cloning, characterization and mRNA expression analysis of a cDNA encoding a type II asparagine synthetase in common bean. (3/128)

Following a RT-PCR strategy based on the design of degenerate oligonucleotides resembling conserved domains of asparagine synthetase (AS; EC 6.3.5.4), we isolated a 2 kb cDNA clone (PVAS2) from root tissue of the common bean (Phaseolus vulgaris). PVAS2 encodes a protein of 584 amino acids with a predicted relative molecular mass of 65810 Da, an isoelectric point of 6.4, and a net charge of -7.2 at pH 7.0. The amino acid sequence of the protein encoded by PVAS2 is very similar to that encoded by the soybean SAS2 asparagine synthetase gene. The amino-terminal residues of the predicted PVAS2 protein are identical to the amino acids that constitute the glutamine-binding (GAT) domain of AS from other plant species, which suggests that the PVAS2 cDNA encodes a type II glutamine-dependent form of asparagine synthetase. Southern blot analysis indicates that the common bean AS is part of a small family composed of at least two genes. Expression analysis by Northern blot revealed that the PVAS2 transcript accumulates to a high level in roots and, to a lesser extent, in nodules and developing pods. Accumulation of the PVAS2 transcript in the root seems to be negatively regulated by light and sucrose, and positively regulated by nitrate.  (+info)

Activation of the unfolded protein response pathway induces human asparagine synthetase gene expression. (4/128)

The gene for the amino acid biosynthetic activity asparagine synthetase (AS) is induced by both amino acid and glucose deprivation of cells. The data reported here document that the human AS gene is induced following activation of the Unfolded Response Pathway (UPR), also known as the Endoplasmic Reticulum Stress Response (ERSR) in mammals. Increased AS transcription occurs in response to glucose deprivation, tunicamycin, or azetidine-2-carboxylate, all known to activate the UPR/ERSR pathway. Previously identified ERSR target genes contain multiple copies of a single highly conserved cis-element. In contrast, the human AS gene does not contain the ERSR element, as it has been described for other responsive genes. Instead, AS induction requires an Sp1-like sequence, a sequence previously shown to be associated with amino acid control of transcription, and possibly, a third region containing no consensus sequences for known transcription factors. Oligonucleotides covering each of these regions form DNA-protein complexes in vitro, and for some the amount of these complexes is greater when nuclear extracts from glucose-starved cells are tested. These results document that a wider range of metabolic activities are activated by the UPR/ERSR pathway than previously recognized and that genomic elements other than those already described can serve to enhance transcription of specific target genes.  (+info)

Using genomic information to investigate the function of ThiI, an enzyme shared between thiamin and 4-thiouridine biosynthesis. (5/128)

The gene thiI encodes a protein (ThiI) that plays a role in the transfer of sulfur from cysteine to both thiamin and 4-thiouridine, but the reaction catalyzed by ThiI remains undetermined. Based upon sequence alignments, ThiI shares a unique "P-loop" motif with the PPi synthetase family, four enzymes that catalyze adenylation and subsequent substitution of carbonyl oxygens. To test whether or not this motif is critical for ThiI function, the Asp in the motif was converted to Ala (D189A), and a screen for in vivo 4-thiouridine production revealed the altered enzyme to be inactive. Further scrutiny of sequence data and the crystal structures of two members of the PPi synthetase family implicated Lys321 in the proposed adenylation function of ThiI, and the critical nature of Lys321 has been demonstrated by site-directed mutagenesis and genetic screening. Our results, then, indicate that ThiI catalyzes the adenylation of a substrate at the expense of ATP, a narrowing of possible reactions that provides a strong new basis for deducing the early steps in the transfer of sulfur from cysteine to both thiamin and 4-thiouridine.  (+info)

A mutation in the Corynebacterium glutamicum ltsA gene causes susceptibility to lysozyme, temperature-sensitive growth, and L-glutamate production. (6/128)

The Corynebacterium glutamicum mutant KY9714, originally isolated as a lysozyme-sensitive mutant, does not grow at 37 degrees C. Complementation tests and DNA sequencing analysis revealed that a mutation in a single gene of 1,920 bp, ltsA (lysozyme and temperature sensitive), was responsible for its lysozyme sensitivity and temperature sensitivity. The ltsA gene encodes a protein homologous to the glutamine-dependent asparagine synthetases of various organisms, but it could not rescue the asparagine auxotrophy of an Escherichia coli asnA asnB double mutant. Replacement of the N-terminal Cys residue (which is conserved in glutamine-dependent amidotransferases and is essential for enzyme activity) by an Ala residue resulted in the loss of complementation in C. glutamicum. The mutant ltsA gene has an amber mutation, and the disruption of the ltsA gene caused lysozyme and temperature sensitivity similar to that in the KY9714 mutant. L-Glutamate production was induced by elevating growth temperature in the disruptant. These results indicate that the ltsA gene encodes a novel glutamine-dependent amidotransferase that is involved in the mechanisms of formation of rigid cell wall structure and in the L-glutamate production of C. glutamicum.  (+info)

Evidence for multiple signaling pathways in the regulation of gene expression by amino acids in human cell lines. (7/128)

In mammals, plasma concentrations of amino acids (AA) are affected by nutritional or pathologic conditions. Alterations in AA profiles have been reported as a result of a deficiency of any one of the essential AA, a dietary imbalance of AA or an insufficient intake of protein. In recent years, evidence has accumulated that AA availability regulates the expression of several genes involved in the regulation of a number of cellular functions or AA metabolism. Nevertheless, the molecular mechanisms involved in the AA regulation of mammalian gene expression are limited, particularly the signaling pathways mediating the AA response. This work provides a better understanding of the signaling pathways involved in the AA control of gene expression. We studied the expression of C/EBP homologous protein (CHOP) and asparagine synthetase (AS) in response to deprivation of a single AA and investigated the possible link between protein synthesis inhibition due to amino acid limitation and gene expression. We have shown the following: 1) several mechanisms are involved in the AA control of gene expression. When omitted from the culture medium, each AA can activate one (or several) specific signaling pathways leading to the regulation of one specific pattern of genes. 2) AA limitation by itself can induce gene expression independently of a cellular stress due to protein synthesis inhibition. Together, these results suggest that AA control of gene expression involves several specific mechanisms by which one AA (or one group of AA) can activate one signaling pathway and thus alter one specific pattern of gene expression.  (+info)

Activation of the human asparagine synthetase gene by the amino acid response and the endoplasmic reticulum stress response pathways occurs by common genomic elements. (8/128)

The human asparagine synthetase (AS) gene is transcriptionally regulated by amino acid deprivation (amino acid response, AAR) and the endoplasmic reticulum stress response (ERSR), also known as the unfolded protein response pathway. The results reported here document the novel observation that induction of the AS gene by the AAR and ERSR pathways occurs via the same set of genomic elements. Data supporting this conclusion include transient transfection of AS promoter/reporter gene constructs that illustrate that the transcriptional control elements used by both pathways are contained with nucleotides -111 to -34 of the AS promoter. In vivo footprinting analysis of this region identified six specific protein-binding sites. Within two of these sites, altered footprinting was observed following amino acid or glucose deprivation, but the patterns were identical for both the AAR and the ERSR pathway. Site-directed mutation of individual nucleotides within these two binding sites confirmed their importance for regulated transcription, and none of the mutations resulted in loss of response of only one pathway. Neither of these two sites corresponds to a recently identified ERSR cis-element, nor do they contain consensus sequences for known transcription factors. Collectively, the data document that there are at least two independent transcriptional mechanisms for gene activation by the ERSR pathway, one of which terminates at the same genomic elements used by the AAR pathway.  (+info)

Asparagine synthase (glutamine-hydrolysing) - WikipediaAsparagine synthase (glutamine-hydrolysing) - Wikipedia
Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden HM, Rayment I (December 1999). Three-dimensional structure of Escherichia coli asparagine synthetase B: a short journey from substrate to product. Biochemistry. 38 (49): 16146-57. CiteSeerX 10.1.1.453.5998. doi:10.1021/bi9915768. PMID 10587437 ...
https://en.wikipedia.org/wiki/Asparagine_synthase_
OriGene - ASNS (NM 001178076) Human ORF cDNA CloneOriGene - ASNS (NM 001178076) Human ORF cDNA Clone
ASNS - ASNS (Myc-DDK-tagged)-Human asparagine synthetase (glutamine-hydrolyzing) (ASNS), transcript variant 5 available for purchase from OriGene - Your Gene Company.
http://www.origene.com/orf_clone/trueclone/NM_001178076/RC230144/ASNS.aspx
asnB - Asparagine synthetase B - Mycobacterium tuberculosis variant pinnipedii - asnB gene & proteinasnB - Asparagine synthetase B - Mycobacterium tuberculosis variant pinnipedii - asnB gene & protein
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
https://www.uniprot.org/uniprot/A0A328GGJ6
Aspartate-Ammonia Ligase - Asparagine Synthetase Summary Report | CureHunterAspartate-Ammonia Ligase - Asparagine Synthetase Summary Report | CureHunter
Aspartate-Ammonia Ligase: An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP. EC 6.3.1.1.
http://www.curehunter.com/public/keywordSummaryD001217-Aspartate-Ammonia-Ligase-Asparagine-Synthetase.do
ASNS Gene - GeneCards | ASNS Protein | ASNS AntibodyASNS Gene - GeneCards | ASNS Protein | ASNS Antibody
Complete information for ASNS gene (Protein Coding), Asparagine Synthetase (Glutamine-Hydrolyzing), including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASNS
Plus itPlus it
Targeting amino acid metabolism has therapeutic implications for aggressive brain tumors. Asparagine is an amino acid that is synthesized by normal cells. However, some cancer cells lack asparagine synthetase (ASNS), the key enzyme for asparagine synthesis. Asparaginase (ASNase) contributes to eradication of acute leukemia by decreasing asparagine levels in serum and cerebrospinal fluid. However, leukemic cells may become ASNase-resistant by up-regulating ASNS. High expression of ASNS has also been associated with biological aggressiveness of other cancers, including gliomas. Here, the impact of enzymatic depletion of asparagine on proliferation of brain tumor cells was determined. ASNase was used as monotherapy or in combination with conventional chemotherapeutic agents. Viability assays for ASNase-treated cells demonstrated significant growth reduction in multiple cell lines. This effect was reversed by glutamine in a dose-dependent manner -- as expected, because glutamine is the main amino ...
http://mcr.aacrjournals.org/content/early/2014/02/06/1541-7786.MCR-13-0576
Asparagine synthetase Overexpression Lysate (Adult Normal), Novus Biologicals (NBL1-07768) | VWRAsparagine synthetase Overexpression Lysate (Adult Normal), Novus Biologicals (NBL1-07768) | VWR
Special note about Community Feature Content. Any content and/or opinions uploaded, expressed or submitted through any Community Feature or any other publicly available section of the Web Site (including password-protected areas), and all articles and responses to questions, other than the content explicitly authorized by the Company, are solely the opinions and responsibility of the person or entity submitting them and do not necessarily reflect the opinions of the Company. By way of example, any recommended or suggested use of products or services available from the Company that is posted through a Community Feature is not a sign of approval or recommendation by the Company. If you choose to follow any such recommendation you do so at your own risk.. Links to Third Party Sites. The Web Site may contain links to other websites on the internet. The Company is not responsible for the content, products, services or practices of any third party websites, including without limitation sites linked to ...
https://us.vwr.com/store/product/9696419/asparagine-synthetase-overexpression-lysate-adult-normal-novus-biologicals-nbl1-07768
WikiGenes - ASNSD1 - asparagine synthetase domain containing 1WikiGenes - ASNSD1 - asparagine synthetase domain containing 1
The worlds first wiki where authorship really matters. Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts.
https://www.wikigenes.org/e/gene/e/54529.html
Limiting Dietary Asparagine Could Reduce Cancer SpreadLimiting Dietary Asparagine Could Reduce Cancer Spread
Technology Networks is an internationally recognised publisher that provides access to the latest scientific news, products, research, videos and posters.
https://www.technologynetworks.com/applied-sciences/news/limiting-dietary-asparagine-could-reduce-cancer-spread-297287
Anti-Asparagine synthetase antibody [EP282Y] (ab40850)Anti-Asparagine synthetase antibody [EP282Y] (ab40850)
Rabbit recombinant monoclonal Asparagine synthetase antibody [EP282Y] validated for WB, IHC, ICC/IF and tested in Human, Mouse and Rat. Referenced in 3…
http://www.abcam.com/asparagine-synthetase-antibody-ep282y-ab40850.html
INRA - NitroScapeINRA - NitroScape
NitroScape is an integrated modelling tool that simulates at landscape level the entire nitrogen transfer and transformation process. The most effective scale for developing nitrogen mitigation strategies is landscape level.
http://www.inra.fr/en/Scientists-Students/Agricultural-systems/All-reports/Modelling-and-agrosystems/NitroScape/
Root parasite induced nitrogen transfer between plants is density dependent - Citation formats | Research Explorer | The...
TY - JOUR. T1 - Root parasite induced nitrogen transfer between plants is density dependent. AU - Dromph, Karsten M.. AU - Cook, Roger. AU - Ostle, Nick J.. AU - Bardgett, Richard D.. N1 - Dromph, Karsten M. Cook, Roger Ostle, Nick J. Bardgett, Richard D.. PY - 2006/8. Y1 - 2006/8. N2 - Recent studies point to the importance of soil borne parasites as agents of vegetation change via their negative effect on host plants. Here we show that these soil organisms can influence vegetation characteristics by increasing the transfer of the plant growth-limiting nutrient nitrogen (N) from their host, a N-fixing legume, to neighbouring grass species, thereby benefiting the growth of the neighbour. Furthermore, the amount of N transferred from the legume to the neighbour, and its consequent effect on the neighbours growth, was dependant on the density of root infestation. This mechanism of N transfer from legumes to neighbouring plant species is likely to be an important agent of vegetation change. © 2006 ...
https://www.research.manchester.ac.uk/portal/en/publications/root-parasite-induced-nitrogen-transfer-between-plants-is-density-dependent
anti-Asparagine synthetase antibody | GeneTexanti-Asparagine synthetase antibody | GeneTex
Asparagine synthetase antibody (asparagine synthetase (glutamine-hydrolyzing)) for IHC-P, WB. Anti-Asparagine synthetase pAb (GTX114269) is tested in Human samples. 100% Ab-Assurance.
http://www.genetex.com/Asparagine-synthetase-antibody-GTX114269.html
ASNS Antibody (monoclonal) (M01) - Mouse monoclonal antibody raised against a partial recombinant ASNS. E - Buy Now! |AbgentASNS Antibody (monoclonal) (M01) - Mouse monoclonal antibody raised against a partial recombinant ASNS. E - Buy Now! |Abgent
ASNS Antibody (monoclonal) (M01), Mouse monoclonal antibody raised against a partial recombinant ASNS. validated in E (AT1217a), Abgent
http://www.abgent.com/products/AT1217a-ASNS-Antibody-monoclonal-M01
The Yang Research Group - Members - Hee Sun Chung
L-Asparaginase (ASNase) is a drug used in treatment of acute lymphoblastic leukemia. In presence of this enzyme the asparagine, an essential amino acid for biosynthesis, is converted to aspartic acid and ammonia. The malignant cells in patients with ASNase sensitive leukemia depend on exogenous supply of asparagine for survival. Administration of ASNase results in rapid reduction of systemic asparagine causing apoptosis of cancer cells. The effect of this enzyme on normal cells is not significant compared to the malignant cells as the normal cells are capable of generating their own source of asparagine through aspartic acid by way of asparagine synthetase.. Despite its effectiveness, the use of ASNase is not without problems. Due to its bacterial origin, namely E. coli and Erwinia carotovora, ASNase causes immunogenic response in patients and requires administration in hospital setting. The problem is compounded by the fact that ASNase has short half-life which in turn necessitates frequent ...
http://www-personal.umich.edu/~vcyang/html/heesunchung.htm
Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation on...Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation on...
Article Autophosphorylation-induced degradation of the Pho85 cyclin Pcl5 is essential for response to amino acid limitation. Pho85 cyclins (Pcls), activators of the yeast cyclin-dependent kinase (CDK) Pho85, belong together with the p35 activator of ...
https://www.environmental-expert.com/articles/autophosphorylation-induced-degradation-of-the-pho85-cyclin-pcl5-is-essential-for-response-to-amino--39570
Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from AbcamRabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam
Rabbit Anti-Asparagine synthetase Monoclonal Antibody, Unconjugated, Clone EP282Y from Abcam,Rabbit monoclonal [EP282Y] to Asparagine synthetase ( P08243,biological,biology supply,biology supplies,biology product
http://www.bio-medicine.org/biology-products/Rabbit-Anti-Asparagine-synthetase-Monoclonal-Antibody--Unconjugated--Clone-EP282Y-from-Abcam-5681-1/
RCSB PDB for 11ASRCSB PDB for 11AS
11AS: Crystal structure of asparagine synthetase reveals a close evolutionary relationship to class II aminoacyl-tRNA synthetase.
http://www.rcsb.org/pdb/explore/biologyAndChemistry.do?structureId=11AS
ASNSP4 Gene - GeneCards | ASNSP4 PseudogeneASNSP4 Gene - GeneCards | ASNSP4 Pseudogene
Complete information for ASNSP4 gene (Pseudogene), Asparagine Synthetase Pseudogene 4, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
http://www.genecards.org/cgi-bin/carddisp.pl?gene=ASNSP4
Sočasna okužba - Wikipedija, prosta enciklopedijaSočasna okužba - Wikipedija, prosta enciklopedija
Sočasna okužba, sookužba ali koinfekcija je hkratna okužba celice ali organizma z dvema mikroorganizmoma (na primer pljučnica, ki jo povzročata ortomiksovirus in streptokok).[1] Kadar pa se nova okužba pridruži že obstoječi kasneje in ne istočasno, govorimo o nadokužbi (naknadni okužbi).[2] V svetovnem merilu je pogosta sookužba z jetiko (tuberkulozo) in HIV-om. V nekaterih državah je do 80 % bolnikov s tuberkulozo okuženih tudi z virusom HIV.[3] Nadalje je okoli 10 % bolnikov, okuženih s HIV-om, sočasno okuženih tudi z virusom hepatitisa B.[4] Pri okužbi s HIV-om pa je možna tudi sookužba z več sevi istega virusa; kadar pa se bolnik najprej okuži z enim sevom virusa, kasneje v življenju pa še z drugim, gre za nadokužbo.[5] ...
https://sl.wikipedia.org/wiki/So%C4%8Dasna_oku%C5%BEba
ASNA1 Antibody Mouse Anti Human | TRC40 Antibody | ProSpecASNA1 Antibody Mouse Anti Human | TRC40 Antibody | ProSpec
Anti-human ASNA1 mAb, clone PAT2A1AT, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c immunized mice.
https://www.prospecbio.com/asna1_antibody
Publications | FIRE
Billen G, Garnier J, Lassaletta L. 2013. The nitrogen cascade from agricultural soils to the sea: modelling nitrogen transfers at regional watershed and global scales. Philosophical Transactions of the Royal Society B: Biological Sciences. 368:20130123-20130123. ...
https://www.fire.upmc.fr/?q=en/biblio&%3Bamp%3Bf%5Bkeyword%5D=376&%3Bamp%3Bf%5Bauthor%5D=227&%3Bf%5Bauthor%5D=1361&f%5Bauthor%5D=353&s=type&o=desc
Publications | FIRE
Billen G, Garnier J, Lassaletta L. 2013. The nitrogen cascade from agricultural soils to the sea: modelling nitrogen transfers at regional watershed and global scales. Philosophical Transactions of the Royal Society B: Biological Sciences. 368:20130123-20130123. ...
https://www.fire.upmc.fr/?q=en/biblio&page=1&%3Bamp%3Bf%5Bkeyword%5D=489&%3Bamp%3Bs=title&%3Bamp%3Bo=asc&%3Bf%5Bauthor%5D=1788&f%5Bauthor%5D=353&s=type&o=asc
Summary, Analysis & Review of Ryan Holidays and Stephen Hanselmans the Daily Stoic by Instaread: Price Comparison on BookoSummary, Analysis & Review of Ryan Holidays and Stephen Hanselmans the Daily Stoic by Instaread: Price Comparison on Booko
Prices (including delivery) for Summary, Analysis & Review of Ryan Holidays and Stephen Hanselmans the Daily Stoic by Instaread by Instaread. ISBN: asnB01MS6IHZD
https://booko.com.au/B01MS6IHZD/Summary-Analysis-Review-of-Ryan-Holiday-s-and-Stephen-Hanselman-s-the-Daily-Stoic-by-Instaread
The side chain of serine can form a hydrogen bond... - OpenStudyThe side chain of serine can form a hydrogen bond... - OpenStudy
The side chain of serine can form a hydrogen bond with the side chain of which of the following amino acids? threonine asparigine Can someone expla...
http://openstudy.com/updates/4fd76229e4b08820575626bc
physiology test question xW8cW2g0mme2z2yeBqiy2DQromZiLo4T.htmlphysiology test question xW8cW2g0mme2z2yeBqiy2DQromZiLo4T.html
Physiology Test Question - Which of the following amino acids serves as a precursor or intermediary metabolite in the biosynthetic pathway of the neurotransmitter/hormone epinephrine?
http://www.physiologyweb.com/test_questions/physiology_test_question_xW8cW2g0mme2z2yeBqiy2DQromZiLo4T.html
Researchers discover glutamine-dependent activation of cell growth and autophagyResearchers discover glutamine-dependent activation of cell growth and autophagy
The human body consists of about 35 trillion cells, so it could be said that overall body growth is the growth of individual cells.
https://www.news-medical.net/news/20180503/Researchers-discover-glutamine-dependent-activation-of-cell-growth-and-autophagy.aspx
Gentaur Molecular :Sceti K.K. \ L Asparagine \ 2703Gentaur Molecular :Sceti K.K. \ L Asparagine \ 2703
Gentaur molecular products has all kinds of products like :search , Sceti K.K. \ L_Asparagine \ 2703 for more molecular products just contact us
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AS2906 Netflix Streaming Services Inc. - WhoisRequestAS2906 Netflix Streaming Services Inc. - WhoisRequest
The organization Netflix Streaming Services Inc. allocates 138 IP netblocks under the autonomous system number (ASN ) of 2906. The regional internet registry (RIR ) for this ASN is ARIN. The country in which these IPs are located is United States of America (US), which is on #1 out of 249 countries by the total amount of ASNs allocated - 27,927 ...
https://whoisrequest.com/ip/AS2906
Skopolamin - Wikipedija, prosta enciklopedijaSkopolamin - Wikipedija, prosta enciklopedija
Pogosti stranski učinki so povezani z antiholinergičnim delovanjem na parasimpatične postsinaptične receptorje: suha usta, grlo, nos, ob prekomernih odmerkih oslabljen govor, ki se lahko stopnjuje do mrmranja, podobnega glasovom rakuna; žeja, zamegljen vid in občutljivost na svetlobo, zaprtje, težave pri uriniranju in tahikardija. Ostali stranski učinki: pordelost, povišana temperatura, razburjenje, nemirnost, halucinacije, delirij, sploh pri višjih odmerkih. Našteti stranski učinki nastopijo ob peroralni ali parenteralni aplikaciji učinkovine, ne pa ob topični ali okularni uporabi. Ekstremni zaplet ob zaužitju zelo visokih odmerkov skopolamina in sorodnih drog je začasna slepota, ki lahko traja do 72 ur.. Vročina in izsušitev zaradi skopolamina lahko prisilita uporabnike tega mamila, da se poskušajo ohladiti v različnih vodnih zajetjih in se tam utopijo.. Stranski učinki skopolamina se lahko zamenjajo za simptome raka zaradi prisotne slabosti in različno velikih zenic ...
https://sl.wikipedia.org/wiki/Skopolamin
Human Metabolome Database: Showing metabocard for L-Asparagine (HMDB0000168)Human Metabolome Database: Showing metabocard for L-Asparagine (HMDB0000168)
Asparagine (Asn) is one of the 20 most common natural amino acids on Earth. It has carboxamide as the side chains functional group. Asparagine is not an essential amino acid, which means that it can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. The precursor to asparagine is oxaloacetate. Oxaloacetate is converted to aspartate using a transaminase enzyme. The enzyme transfers the amino group from glutamate to oxaloacetate producing alpha-ketoglutarate and aspartate. The enzyme asparagine synthetase produces asparagine, AMP, glutamate, and pyrophosphate from aspartate, glutamine, and ATP. In the asparagine synthetase reaction, ATP is used to activate aspartate, forming beta-aspartyl-AMP. Glutamine donates an ammonium group which reacts with beta-aspartyl-AMP to form asparagine and free AMP. Since the asparagine side chain can make efficient hydrogen bond interactions with the peptide backbone, asparagines are often found near the beginning ...
https://hmdb.ca/metabolites/HMDB0000168
Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein responseAmino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response
The gene encoding CHOP (C/EBP-homologous protein) is transcriptionally activated by many stimuli and by amino acid deprivation. CHOP induction was considered to be due to an accumulation of unfolded protein into the ER (unfolded protein response (UPR)). We investigate the role of the UPR in the indu …
https://pubmed.ncbi.nlm.nih.gov/10218478/?dopt=Abstract
CAS 154395-64-9 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-Asparagine - BOC SciencesCAS 154395-64-9 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-Asparagine - BOC Sciences
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Eine neuartige 1,2-Methyl-Wanderung bei der Desaminierung Decarboxylierung von 3- Amino-CyclopentancarbonsäurenEine neuartige 1,2-Methyl-Wanderung bei der Desaminierung Decarboxylierung von 3- Amino-Cyclopentancarbonsäuren
During deamination, γ-amino acids can undergo concomitant decarboxylation. Aiming at studying the course of the involved reaction, the following γ-amino acids were synthesized and characterized: (-)-3c-amino-1,2,2-trimethylcyclopentane-1r-carboxylic acid (= (-)-aminolauronic acid = (-)-3-aminocamphonanic acid; 39), cis-3-aminocyclopentanecarboxylic acid (41), (+)-3c-amino-2,2,3-trimethylcyclopentane-1r-carboxylic acid (= (-)-aminodihydrocampholytic acid; 42), and the novel (±)-cis-3-amino-2,2-dimethylcyclopentanecarboxylic acid (43). These γ-amino acids were deaminated by means of 4-diazoniobenzenesulfonate (= p-diazobenzenesulfonic acid; generated from p-sulfanilic acid = 4-aminobenzenesulfonic acid), under moderately basic aqueous conditions (pH 8-9). The formed product mixtures were separated, the products identified, and their structures correlated with the starting γ-amino acids, thus establishing that decarboxylation occurs whenever the carbenium ion formed by loss of nitrogen can ...
https://infoscience.epfl.ch/record/30615
Asparagine essential for brain development | Health24Asparagine essential for brain development | Health24
The amino acid asparagine was until now considered non-essential because it is produced naturally by the body. However, researchers found that it is essential for normal brain development.
http://www.health24.com/Mental-Health/Brain/News/Asparagine-essential-for-brain-development-20131125
Gentaur Molecular :Biosera \ L Asparagine Monohydrate 100g \ PM-P1404/100Gentaur Molecular :Biosera \ L Asparagine Monohydrate 100g \ PM-P1404/100
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Hebrew Universitys Methylation Maestro | CFHUHebrew Universitys Methylation Maestro | CFHU
Lab rat. Cedar says he was not the best student in NYUs MD/PhD program, but he did enjoy learning about the life sciences. I was infatuated with general biology principles. It was the beginning of the molecular biology revolution, says Cedar. After three years of medical school and clinical rotations, Cedar chose to work with James Schwartz, who started at NYU as a microbiologist and then became a neurobiologist, using the sea slug Aplysia to study how memory works. Part of Schwartzs research included examining how learning affects chromatin structure. Cedar was Schwartzs first graduate student. Its very good to be the first graduate student; you get a lot of attention, says Cedar. He studied E. colis synthesis of L-asparaginase, which catalyzes the hydrolysis of the amino acid asparagine to aspartic acid, and purified asparagine synthetase from the bacterium to study how that enzyme catalyzes the reverse reaction, using aspartate to produce the amino acid in vitro. Cedar enjoyed ...
http://www.cfhu.org/news/hebrew-universitys-methylation-maestro
Measurement of Serum l-Asparagine in the Presence of l-Asparaginase Requires the Presence of an l-Asparaginase Inhibitor |...Measurement of Serum l-Asparagine in the Presence of l-Asparaginase Requires the Presence of an l-Asparaginase Inhibitor |...
The antileukemic activity of l-asparaginase (ASNase), an important component of therapy for acute lymphoblastic leukemia, is thought to result from depletion of serum l-asparagine (Asn). In studies of the pharmacological effects of ASNase, investigators have reported prolonged reduction in the serum concentration of Asn after the administration of ASNase. Such measurements may not be valid because ASNase present in the blood sample may hydrolyze Asn before its determination. We examined recovery of [U-14C]Asn from blood samples with and without various concentrations of added ASNase. In the presence of ≥0.01 IU/ml of ASNase, the amount of [U-14C]Asn recovered was ,15% of that without ASNase. Utilizing this assay, we studied the effect of 2 known inhibitors of ASNase in an attempt to improve Asn recovery. In the presence of aspartic β semialdehyde (ASA), or 5-diazo-4-oxo-l-norvaline (DONV), and up to 1.0 IU/ml ASNase, Asn levels remained at ,90% of control. ASA prevented the hydrolysis of ...
http://cancerres.aacrjournals.org/content/51/24/6568.long
KGI | About KGI | Administration | Sheldon SchusterKGI | About KGI | Administration | Sheldon Schuster
Research and Publications. Schusters research focused on finding new targets for synthesizing mechanism-based inhibitors of disease-related enzymes by studying the relationship between the structure and function of ATP synthase and asparagine synthetase. Schuster also examined the role of mycoplasmal infections in the progression of malignant tumors. His research has been published in the journal Biochemistry. He also has written commentaries that appeared in the journal Biochemistry and Molecular Biology Education.. Honors and Service. Schuster has been active in professional organizations such as the Biotechnology Innovation Organization (BIO) and the Council for Biotechnology Centers. He currently is a features editor of the journal Biochemistry and Molecular Biology Education and a member of its editorial board.. In 2007, the American Association for the Advancement of Science elected Schuster as an AAAS Fellow, an honor given by members to their peers who have made significant ...
http://www.kgi.edu/about-kgi/administration/sheldon-schuster
China High Quality L-Asparagine - China L-AsparagineChina High Quality L-Asparagine - China L-Asparagine
China High Quality L-Asparagine, Find details about China L-Asparagine from High Quality L-Asparagine - Qingdao Sunrise Biotechnology Co., Ltd.
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Plus itPlus it
This study shows a critical role for Asna1 in ensuring β-cell function. Loss of Asna1 in β-cells of mice results in pancreatic hypoinsulinemia, impaired insulin secretion, and early onset diabetes. Additionally, β-cells of Asna1β−/− mice showed impaired PM-to-TGN as well as Golgi-to-ER retrograde transport, ER stress, and mislocalization of Stx5 and Stx6. Of note, we also show that inhibition of retrograde transport at the level of EE-to-TGN in isolated islet and insulinoma cells results in impaired Golgi-to-ER retrograde transport, decreased insulin content, and ER stress. Thus, the findings provide evidence that Asna1 is required in β-cells to ensure retrograde transport, which in turn appears to be essential for ER homeostasis and proinsulin biogenesis. Additionally, the perturbed Golgi-to-ER retrograde transport in Retro-2-treated primary islets suggests that the impairment of this step in Asna1β−/− β-cells likely is secondary to the inhibition of retrograde transport at the ...
http://diabetes.diabetesjournals.org/content/65/1/110
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial))ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial))
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
http://atlasgeneticsoncology.org/Genes/GC_ASNA1.html
Asparagine, molecular model - Stock Image A611/0042 - Science Photo LibraryAsparagine, molecular model - Stock Image A611/0042 - Science Photo Library
Asparagine. Molecular model of the amino acid asparagine. Its chemical formula is C4.H8.N2.O3. Atoms are represented as spheres and are colour- coded: carbon (blue), hydrogen (gold), oxygen (red) and nitrogen (dark blue). Amino acids are the building blocks of proteins. Asparagine is a non-essential amino acid. It can be synthesised by the body and so does not need to come from the diet. Asparagine plays an important role in the folding of protein molecules into their secondary structures (alpha helices and beta sheets). Some proteins (such as haemoglobin, the oxygen- carrying pigment in human blood) cannot function without being folded into the correct shape. - Stock Image A611/0042
http://www.sciencephoto.com/media/6503/view
L-asparagine oxygenase elisa and antibodyL-asparagine oxygenase elisa and antibody
Shop L-asparagine oxygenase ELISA Kit, Recombinant Protein and L-asparagine oxygenase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody are available.
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CAS 160416-17-1 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-asparagine tert-butyl ester - BOC SciencesCAS 160416-17-1 2,3,4,6-Tetra-O-acetyl-b-D-glucopyranosyl-(N2-Fmoc)-L-asparagine tert-butyl ester - BOC Sciences
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L-ASPARAGINE:H2O (1,4-13C2; ALPHA-15N, 98%), Creative Peptides L-Iso-0103 - Creative PeptidesL-ASPARAGINE:H2O (1,4-13C2; ALPHA-15N, 98%), Creative Peptides L-Iso-0103 - Creative Peptides
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Stomatologia Współczesna Suplement 1/1998 - Med Tour Press Int.Stomatologia Współczesna Suplement 1/1998 - Med Tour Press Int.
Słowa kluczowe: leczenie przewlekłych zapaleń tkanek okołowierzchołkowych, preparaty wodorotlenkowapniowe. W leczeniu przewlekłych zapaleń tkanek okołowierzchołkowych istotne jest działanie bakteriobójcze oraz stworzenie warunków do reparacji uszkodzonej kości. Najbardziej skuteczną metodą terapeutyczną okazało się biomechaniczne opracowanie kanału oraz zastosowanie wkładki leczniczej z wodorotlenku wapnia. Celem pracy była własna ocena wpływu nie twardniejących preparatów wodorotlenkowapniowych (Calxyl, Biopulp) na procesy gojenia i odnowy kości w przewlekłych zapaleniach przyzębia przyszczytowego. Leczeniem objęto 96 zębów jedno- i wielokorzeniowych. Na podstawie diagnostycznych zdjęć rtg ustalono średnicę zmian zapalnych. Wyodrębniono ogniska o średnicy do 3 mm, od 3 do 6 mm i powyżej 6 mm. Wkładki lecznicze z preparatów wodorotlenkowapniowych zmieniano co 3 miesiące. Obserwacje radiologiczne przeprowadzono po 3, 6, 9 i 12 miesiącach. Ogółem na 96 ...
http://medtourpress.pl/stomatologia-wspolczesna-suplement-1-1998/
அஸ்பரஜின் - தமிழ் விக்கிப்பீடியாஅஸ்பரஜின் - தமிழ் விக்கிப்பீடியா
அஸ்பரஜின் (Asparagine) (அ) அஸ்பரமைடு [குறுக்கம்: Asn (அ) N; அஸ்பார்டிக் அமிலம் (அ) அஸ்பரஜின் அமினோ அமிலத்தை குறிக்கும் மற்றொரு குறுக்கம்: Asx or B][2] புரதங்களில் அடிப்படையாக உள்ள 20 அமினோ அமிலங்களில் ஒன்றாகும். இதனுடைய வாய்பாடு: 2HN-CO-CH2-CH(NH2)-COOH (அ) C4H8N2O3. இது ஒரு அத்தியாவசியமற்ற ஆல்ஃபா அமினோ அமிலமாகும். அஸ்பரஜின் விலங்குகளினால்/மனிதர்களால் தயாரிக்கப்படக்கூடியது. இதன் குறிமுறையன்கள்: AAU மற்றும் AAC. ...
https://ta.wikipedia.org/wiki/%E0%AE%85%E0%AE%B8%E0%AF%8D%E0%AE%AA%E0%AE%B0%E0%AE%9C%E0%AE%BF%E0%AE%A9%E0%AF%8D
toomanykiwis.comtoomanykiwis.com
Asparagine is an amino acid, which has recently been rumored to aid the spread of breast cancer. Trials on mice have shown that low-asparagine diets, combined with blocking asparagine production in the body, greatly reduced the breast cancers ability to spread.. ...
https://www.toomanykiwis.com/
A Double blind randomized phase 2 PILOT study of ERYASPASE in patients with acute lymphoblastic leukemia/lymphoma | OncologyPROA Double blind randomized phase 2 PILOT study of ERYASPASE in patients with acute lymphoblastic leukemia/lymphoma | OncologyPRO
Asparaginase is a critical agent in the treatment of ALL. This enzyme deaminates asparagine, interfering with protein synthesis and resulting in cell death as lymphoblasts are deficient in asparagine synthetase. Eryaspase is a dispersion of homologous red blood cells (RBCs) encapsulating L-asparaginase formulated in a preservative solution for infusion. The formulation of eryaspase has evolved during its development. Two sources of L-asparaginase (drug substance) from Medac GmbH can be used as raw material and encapsulated in the RBCs: native (Kidrolase®) or recombinant L-asparaginase (Spectrila®). This study is designed to investigate the PK comparability of both eryaspase formulations: native or recombinant asparaginase as the starting material, when administered as monotherapy and in combination with chemotherapy during induction and consolidation phases for the treatment of children and young adults presenting with ALL/LBL. ...
http://oncologypro.esmo.org/Meeting-Resources/ESMO-2017-Congress/A-Double-blind-randomized-phase-2-PILOT-study-of-ERYASPASE-in-patients-with-acute-lymphoblastic-leukemia-lymphoma
Foodista | Recipes, Cooking Tips, and Food News | Asparagine Amino Acid
Translations: Asparagīna Amino Acid, Asparaginas aminorūgšties, Asparagina aminoacizi, Asparagin Aminokiselinska, Amino Acid Asparagine, Asparaginy aminokwasów, Asparagine एमिनो एसिड, Aminoácido asparagina, Аспарагин Аминокислоты, Ασπαραγίνη Αμινοξύ, الهليونين الأحماض الأمينية, 아스파라긴 아미노산, Asparagin aminokyselin, Asparagina Asam Amino, Asparagine Amino acid, 天冬酰胺氨基酸, Asparagina Aminoàcids, Asparagin Amino Acid, Asparagín aminokyselín, Amminoacido asparagina, אספרגין חומצה אמינו, Asparagin Amino Acid, Аспарагин амино киселина, アスパラギンアミノ酸, Acide aminé asparagine, Asparagin Amino Acid, Asparagin Amino Acid, Asparaginer Amino Acid, Asparagina Aminoácidos, Аспарагін Амінокислоти, Asparagiini Aminohappo, Аспарагин амино ...
http://www.foodista.com/food/HS2S3ND5/asparagine-amino-acid
Belgium | Ashoka | Everyone a ChangemakerBelgium | Ashoka | Everyone a Changemaker
The Ashoka Support Network (ASN) is a global community of successful, innovative leaders from a variety of fields who connect with the worlds leading social entrepreneurs to accelerate positive social change. They support Ashoka financially as well as strategically by offering their time and expertise and opening their networks to Ashoka.. Our strong and committed Belgian Ashoka Support Network go far beyond the role of anonymous donors. At Ashoka Belgium, we work hard on creating a true bond between our ASNs and our Fellows:. In Belgium, we have a support committee called the FEST, which is recommended and implemented for each new Fellow joining Ashoka. This committee is composed of the Fellow and one to two ASN members committed to supporting and counselling the Fellow. The aim of FEST is to guide the Fellow in their entrepreneurial track and help them with personal or professional issues to allow them to move forward in the development of their project. Sessions between the ASNs and Fellow ...
https://www.ashoka.org/en/country/belgium
AS29550 Simply Transit Ltd - WhoisRequestAS29550 Simply Transit Ltd - WhoisRequest
The organization Simply Transit Ltd allocates 26 IP netblocks under the autonomous system number (ASN ) of 29550. The regional internet registry (RIR ) for this ASN is RIPE. The country in which these IPs are located is United Kingdom of Great Britain and Northern Ireland (GB), which is on #5 out of 249 countries by the total amount of ASNs allocated - 2,830 ...
https://whoisrequest.com/ip/AS29550
L-Asparagine monohydrate - Astral Scientific
Po Box 232, Gymea NSW 2227. PHONE: (02) 9540 2055. EMAIL: [email protected] ABN: 82 003 316 603. AS/NZS ISO 9001:2015. ...
https://astralscientific.com.au/products/bioab0017
Matthew Patrick - Island Soul - Guestbook
Najem samochodów dostawczych w Warszawie jakkolwiek usługa idealnie skrojona na ilość potrzeb współczesnego Konsumenta! Stolica jest stroną, w jakiej idzie relatywnie sporo wypożyczalni wypożyczalnia aut dostawczych warszawa (click https://hellogoodbyethankyou.tumblr.com/), natomiast ich mężczyznami są nie tylko przybywający tu w handlach biznesmeni, jakkolwiek dodatkowo zwykli obywatele Najważniejszym mieście, jacy wymagają samochodu naprawdę rzadko, iż nie finansuje im się umieć go na cecha - po prostu w razie sprawy go wynajmują. Jesteśmy skupieni na nowoczesnym, aby dać Państwu kompletne szczęście - niezależnie od aktualnego, lub potrzebują Państwo zdecydować się na wynajem krótkoterminowy, średnioterminowy albo i długoterminowy, własna oferta zawsze stanowi efektywna a będzie ekskluzywnym wsparciem niezależnie z robionej poprzez Państwa działalności. Interes prowadzi także możliwość rezerwacji telefonicznej, i swej w lokalnej wypożyczalni ...
http://matthewpatrickfeuer.com/guestbook.html
Tumor - OrthopaedicsOne Articles - OrthopaedicsOneTumor - OrthopaedicsOne Articles - OrthopaedicsOne
Browse Articles by Topic Tumor Chart - Summary table of the seven questions to ask, differential diagnosis and important information about each tumor. Musculoskeletal tumors - The five presenting complaints Soft tissue mass Painless bony mass Bone
https://www.orthopaedicsone.com/display/Main/Tumor?atl_token=dba6d0bc6482a0790b4b1af3d6b82f6a966d4e7c
Aspartate-ammonia ligaseAspartate-ammonia ligase
In enzymology, an aspartate-ammonia ligase (EC 6.3.1.1) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (AMP-forming). Other names in ... This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... Webster GC, Varner JE (1955). "Aspartate metabolism and asparagine synthesis in plant systems". J. Biol. Chem. 215: 91-99. PMID ...
https://en.wikipedia.org/wiki/Aspartate—ammonia_ligase
Aspartate-ammonia ligase (ADP-forming)Aspartate-ammonia ligase (ADP-forming)
... an aspartate-ammonia ligase (ADP-forming) (EC 6.3.1.4) is an enzyme that catalyzes the chemical reaction ATP + L-aspartate + ... ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (ADP-forming). Other names in ... This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... L-aspartate, and NH3, whereas its 3 products are ADP, phosphate, and L-asparagine. ...
https://en.wikipedia.org/wiki/Aspartate—ammonia_ligase_(ADP-forming)
Asparagine synthetaseAsparagine synthetase
... (or aspartate-ammonia ligase) is a chiefly cytoplasmic enzyme that generates asparagine from aspartate. ... This domain is responsible for the binding of both Mg2+ATP and aspartate. These two active sites are connected by a tunnel ... The human glutamine-dependent AS is encoded by a single gene located in region q21.3 on chromosome 7. The lack of ammonia- ... Thus, after being released in, and channeled from, the glutaminase site, the ammonia molecule attacks the bound βAspAMP 1 to ...
https://en.wikipedia.org/wiki/Asparagine_synthetase
List of MeSH codes (D08)List of MeSH codes (D08)
... aspartate-ammonia ligase MeSH D08.811.464.259.200.600 - glutamate-ammonia ligase MeSH D08.811.464.259.300 - argininosuccinate ... alanine-tRNA ligase MeSH D08.811.464.263.200.100 - arginine-tRNA ligase MeSH D08.811.464.263.200.150 - aspartate-tRNA ligase ... ammonia-lyases MeSH D08.811.520.232.400.200 - aspartate ammonia-lyase MeSH D08.811.520.232.400.350 - ethanolamine ammonia-lyase ... valine-tRNA ligase MeSH D08.811.464.267.500 - coenzyme a ligases MeSH D08.811.464.267.500.200 - acetate-coa ligase MeSH D08.811 ...
https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D08)
D-aspartate ligaseD-aspartate ligase
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ... In enzymology, a D-aspartate ligase (EC 6.3.1.12) is an enzyme that catalyzes the chemical reaction ATP + D-aspartate + [beta- ... n ligase (ADP-forming). Other names in common use include Aslfm, UDP-MurNAc-pentapeptide:D-aspartate ligase, and D-aspartic ... Heijenoort J, Legrand R, Brouard JP, Rice L, Mainardi JL (2006). "Aslfm, the D-aspartate ligase responsible for the addition of ...
https://en.wikipedia.org/wiki/D-aspartate_ligase
List of EC numbers (EC 6)List of EC numbers (EC 6)
... aspartate-ammonia ligase (ADP-forming) EC 6.3.1.5: NAD+ synthase EC 6.3.1.6: glutamate-ethylamine ligase EC 6.3.1.7: 4- ... valine-tRNA ligase EC 6.1.1.10: methionine-tRNA ligase EC 6.1.1.11: serine-tRNA ligase EC 6.1.1.12: aspartate-tRNA ligase EC ... aspartate-ammonia ligase EC 6.3.1.2: glutamine synthetase EC 6.3.1.3: Now EC 6.3.4.13, phosphoribosylamine-glycine ligase EC ... asparagine-tRNA ligase EC 6.1.1.23: aspartate-tRNAAsn ligase EC 6.1.1.24: glutamate-tRNAGln ligase EC 6.1.1.25: The tRNAPyl is ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_6)
List of EC numbers (EC 2)List of EC numbers (EC 2)
... aspartate kinase EC 2.7.2.5: Now EC 6.3.4.16, carbamoyl-phosphate synthase (ammonia) EC 2.7.2.6: formate kinase EC 2.7.2.7: ... glutamate-tRNA ligase, EC 1.2.1.70, glutamyl-tRNA reductase and EC 5.4.3.8 EC 2.7.2.14: branched-chain-fatty-acid kinase EC 2.7 ... ammonia kinase EC 2.7.3.9: phosphoenolpyruvate-protein phosphotransferase EC 2.7.3.10: agmatine kinase EC 2.7.3.11: now EC 2.7. ... aspartate transaminase EC 2.6.1.2: alanine transaminase EC 2.6.1.3: cysteine transaminase EC 2.6.1.4: glycine transaminase EC ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_2)
BiosynthesisBiosynthesis
... asparagine synthetase catalyzes the addition of nitrogen from glutamine or soluble ammonia to aspartate to yield asparagine. ... Okazaki fragments are covalently joined by DNA ligase to form a continuous strand. Then, to complete DNA replication, RNA ... The biosynthesis of aspartate is a one step reaction that is catalyzed by a single enzyme. The enzyme aspartate ... The aspartate family of amino acids includes: threonine, lysine, methionine, isoleucine, and aspartate. Lysine and isoleucine ...
https://en.wikipedia.org/wiki/Biosynthesis
AmphetamineAmphetamine
CYP2D6, dopamine β-hydroxylase (DBH), flavin-containing monooxygenase 3 (FMO3), butyrate-CoA ligase (XM-ligase), and glycine N- ... The review indicated that magnesium L-aspartate and magnesium chloride produce significant changes in addictive behavior; other ... Another method is the reaction of phenylacetone with ammonia, producing an imine intermediate that is reduced to the primary ... This reaction is catalyzed by the HXM-A and HXM-B medium-chain acid:CoA ligases and requires energy in the form of ATP. ... The ...
https://en.wikipedia.org/wiki/Amphetamine
List of enzymesList of enzymes
Glutarate-CoA ligase EC 6.2.1.7: Cholate-CoA ligase EC 6.2.1.8: Oxalate-CoA ligase EC 6.2.1.9: Malate-CoA ligase EC 6.2.1.10: ... EC 2.1.3 Aspartate transcarbamoylase EC 2.1.3.2 Ornithine transcarbamoylase EC 2.1.3.3 Category:EC 2.2.1 Transketolase EC 2.2. ... EC 4.3.1 Phenylalanine ammonia-lyase (EC 4.3.1.24) Category:EC 4.4.1 Cystathionine gamma-lyase Cystathionine beta-lyase ... ligase EC 6.2.1.23: Dicarboxylate-CoA ligase EC 6.2.1.24: Phytanate-CoA ligase EC 6.2.1.25: Benzoate-CoA ligase EC 6.2.1.26: o- ...
https://en.wikipedia.org/wiki/List_of_enzymes
MitochondrionMitochondrion
Reducing equivalents from the cytoplasm can be imported via the malate-aspartate shuttle system of antiporter proteins or fed ... For example, mitochondria in liver cells contain enzymes that allow them to detoxify ammonia, a waste product of protein ... kynurenine hydroxylase and fatty acid Co-A ligase. Disruption of the outer membrane permits proteins in the intermembrane space ...
https://en.wikipedia.org/wiki/Mitochondrion
Catalytic triadCatalytic triad
In the first active site, a cysteine triad hydrolyses a glutamine substrate to release free ammonia. The ammonia then diffuses ... The aspartate is hydrogen bonded to the histidine, increasing the pKa of its imidazole nitrogen from 7 to around 12. This ... 1994). "A designed peptide ligase for total synthesis of ribonuclease A with unnatural catalytic residues". Science. 266 (5183 ... Two amino acids have acidic side chains at physiological pH (aspartate or glutamate) and so are the most commonly used for this ...
https://en.wikipedia.org/wiki/Catalytic_triad
List of EC numbers (EC 4)List of EC numbers (EC 4)
D-serine ammonia-lyase EC 4.3.1.19: threonine ammonia-lyase EC 4.3.1.20: erythro-3-hydroxy-L-aspartate ammonia-lyase EC 4.3. ... heme ligase EC 4.99.1.9:: coproporphyrin ferrochelatase * EC 4.99.1.10: magnesium dechelatase * EC 4.99.1.11: sirohydrochlorin ... diaminopropionate ammonia-lyase EC 4.3.1.16: threo-3-hydroxy-L-aspartate ammonia-lyase EC 4.3.1.17: L-serine ammonia-lyase EC ... aspartate ammonia-lyase EC 4.3.1.2: methylaspartate ammonia-lyase EC 4.3.1.3: histidine ammonia-lyase EC 4.3.1.4: ...
https://en.wikipedia.org/wiki/List_of_EC_numbers_(EC_4)
6.3.1.4: aspartate-ammonia ligase (ADP-forming) - BRENDA Enzyme Database6.3.1.4: aspartate-ammonia ligase (ADP-forming) - BRENDA Enzyme Database
... aspartate-ammonia ligase (ADP-forming). This is an abbreviated version!. For detailed information about aspartate-ammonia ... L-aspartate. + NH3. = ADP. + phosphate. + L-asparagine. Synonyms. Asparagine synthetase, Asparagine synthetase (ADP-forming), ... ligase (ADP-forming), go to the full flat file.. Reaction. ATP. + ... 6.3.1 Acid ammonia (or amine) ligases (amide synthases). 6.3.1.4 aspartate-ammonia ligase (ADP-forming) ...
https://brenda-enzymes.org/all_enzymes.php?ecno=6.3.1.4&table=Application
ASNS gene: MedlinePlus GeneticsASNS gene: MedlinePlus Genetics
aspartate ammonia ligase. *glutamine-dependent asparagine synthetase. *TS11. *TS11 cell cycle control protein ... Asparagine helps to break down toxic ammonia within cells, is important for protein modification, and is needed for making a ...
https://medlineplus.gov/genetics/gene/asns/
Nicholas Rattray - Research output - University of StrathclydeNicholas Rattray - Research output - University of Strathclyde
Aspartate-Ammonia Ligase 36% 18 Citations (Scopus) 9 Downloads (Pure) * 2019 Metabolic dysregulation in vitamin E and carnitine ...
https://pureportal.strath.ac.uk/en/persons/nicholas-rattray/publications/
DeCSDeCS
Aspartate-Ammonia Ligase Entry term(s). Asparagine Synthase Asparagine Synthetase Aspartate Ammonia Ligase Ligase, Aspartate- ... Aspartate Ammonia Ligase. Ligase, Aspartate-Ammonia. Synthase, Asparagine. Synthetase B, Asparagine. Synthetase, Asparagine. ... L-Aspartate:ammonia ligase (AMP-forming) Previous Indexing:. Ammonia (1973-1974). Aspartic Acid (1973-1974). Ligases (1973-1974 ... 95: was ASPARAGINE SYNTHETASE 1975-94 (see under LIGASES 1975-90). Online Note:. use ASPARTATE-AMMONIA LIGASE to search ...
https://decs.bvsalud.org/en/ths/resource/?id=1224
Code System Concept
Aspartate-ammonia ligase (substance). Code System Preferred Concept Name. Aspartate-ammonia ligase (substance). ... Aspartate-ammonia ligase Active Synonym false false 6200014 Asparagine synthetase Active Synonym false false ...
https://phinvads.cdc.gov/vads/ViewCodeSystemConcept.action?oid=2.16.840.1.113883.6.96&code=3070009
HOMD :: SEQF3493HOMD :: SEQF3493
aspartate--ammonia ligase. 136. SEQF3493,VSEW01000015.1. TYA87311.1 jb [NA] [AA] 453/150. 18498-18950. transcriptional ...
https://ehomd.org/genome/explorer?gid=SEQF3493&anno=ncbi
CCL17371 details
aspartate-ammonia ligase activity. IEP. Enrichment. MF. GO:0004812. aminoacyl-tRNA ligase activity. IEP. Enrichment. ...
https://bacteria.sbs.ntu.edu.sg/sequence/view/2087
Chromosomal localization of human genes required for G|sub|1|/sub| progression in mammalian cells - Fingerprint - Albert...Chromosomal localization of human genes required for G|sub|1|/sub| progression in mammalian cells - Fingerprint - Albert...
Aspartate-Ammonia Ligase 52% * Rodentia 51% * Chromosomes 49% * Chromosomes, Human, Pair 7 39% ...
https://einstein.pure.elsevier.com/en/publications/chromosomal-localization-of-human-genes-required-for-gsub1sub-pro/fingerprints/
HOMD :: SEQF2940HOMD :: SEQF2940
Aspartate--tRNA(Asp/Asn) ligase. 186. SEQF2940,KI515728.1. SEQF2940_00189 jb [NA] [AA] 933/310. 191067-191999. hypothetical ... Aspartate ammonia-lyase. 79. SEQF2940,KI515728.1. SEQF2940_00081 jb [NA] [AA] 846/281. 81359-80514. ATP ... Pup--protein ligase. 70. SEQF2940,KI515728.1. SEQF2940_00072 jb [NA] [AA] 192/63. 69135-68944. Prokaryotic ubiquitin-like ... Alanine--tRNA ligase. 183. SEQF2940,KI515728.1. SEQF2940_00186 jb [NA] [AA] 1386/461. 187677-186292. putative AAA domain- ...
https://www.homd.org/genome/explorer?gid=SEQF2940&anno=prokka
Domain IPR003439:ABC transporter-likeDomain IPR003439:ABC transporter-like
Aspartate--ammonia ligase 10 Domain IPR025895:Lysine-2,3-aminomutase, C-terminal domain 10 Active_site IPR019756:Peptidase S26A ... Aspartate ammonia-lyase 5 Domain IPR021029:DNA polymerase III, tau subunit, domain V 5 Domain IPR025832:GxGYxYP putative ... Asparagine-tRNA ligase 16 Family IPR005921:Histidine ammonia-lyase 16 Domain IPR032712:AsmA-like, C-terminal 16 Family ... Ethanolamine ammonia-lyase light chain 3 Family IPR011957:Benzoate-CoA ligase family 3 Family IPR022448:Quinoprotein ...
https://www.cbrc.kaust.edu.sa/aamg/1502720332816_CamiLowProdigalV2_40.0_intikhab/WWWAAMG/visuals/CamiLowProdigalV2_AAMG_DOMAINS_data_summary.txt
"sequence id","alias","species","description",...
"Glutamate-ammonia-ligase adenylyltransferase [Ensembl]. GlnD PII-uridylyltransferase, Glutamate-ammonia ligase ... ","aspartate kinase, monofunctional class [Ensembl]. CASTOR, Aspartate/glutamate/uridylate kinase [Interproscan].","protein_ ... ","UDP-N-acetylmuramate--L-alanine ligase [Ensembl]. Mur ligase family, Mur ligase middle domain [Interproscan].","protein_ ... ","UDP-N-acetylmuramoylalanine--D-glutamate ligase [Ensembl]. Mur ligase family, Mur ligase middle domain [Interproscan]."," ...
https://bacteria.sbs.ntu.edu.sg/go/sequences/table/7203
Pesquisa | Biblioteca Virtual em Saúde - BRASILPesquisa | Biblioteca Virtual em Saúde - BRASIL
Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and ... We observed increased labeling of malate and aspartate in A549 GLUL KO cells, whereas the non-resistant GLUL KO H1299 cells ... The malate and aspartate shuttle supported cellular NADH production and was associated with cellular metabolic fitness. ... We proposed a novel metabolic mechanism in cancer drug resistance where the increased capacity of the malate-aspartate shuttle ...
https://pesquisa.bvsalud.org/brasil/?lang=pt&q=au:Nordstrom,+Anders
Ligase - WikipédiaLigase - Wikipédia
ARNt ligase EC 6.1.1.22 asparagine ARNt ligase EC 6.1.1.23 aspartate ARNt Asn ligase EC 6.1.1.24 glutamate ARNtGln ligase EC ... ligase EC 6.3.4.16 carbamoyl-phosphate synthase (ammonia) EC 6.3.4.17 formate-dihydrofolate ligase EC 6.3.4.18 5-(carboxyamino) ... 6.1.1.9 valine ARNt ligase EC 6.1.1.10 methionine ARNt ligase EC 6.1.1.11 serine ARNt ligase EC 6.1.1.12 aspartate ARNt ligase ... ligase EC 6.2.1.7 cholate-CoA ligase EC 6.2.1.8 oxalate-CoA ligase EC 6.2.1.9 malate-CoA ligase EC 6.2.1.10 acide-CoA ligase ( ...
https://fr.m.wikipedia.org/wiki/Ligase
UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM - Terms starting with 'U' - MEDINDEX.AM
49. glutamate ammonia ligase [An enzyme that catalyzes the conversion of ATP, L-glutamate, and NH3 to ADP, orthophosphate, and ... N methyl D aspartate receptor 7. Glucocorticoid Receptor [Widely expressed by human NR3C1 Gene (NR3 Family) as 6 isoforms, ... carbon nitrogen ligase; 3. glucan [group of polysaccharides composed of repeating glucose units; they can consist of branched ... The brain enzyme also acts on L-cysteate, L-cysteine sulfinate, and L-aspartate. EC 4.1.1.15. ( MSH )] (UMLS (CSP) C0017785) = ...
http://www.medindex.am/glossary/index.php/list/UMLS.+CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM/,G,L,U.xhtml
Overall Nitrogen Metabolism - Amino Acids: Disposal of Nitrogen | BiochemistryOverall Nitrogen Metabolism - Amino Acids: Disposal of Nitrogen | Biochemistry
Nitrogen leaves the body as urea, ammonia, and other products derived from amino acid metabolism. The role of body proteins in ... Note: Enzyme 1 (E1, or activating enzyme) activates Ub, which is then transferred to E2 (conjugating enzyme). E3 (a ligase) ... whereas those with aspartate at their N-terminus have a half-life of only 3 minutes. Additionally, proteins rich in sequences ...
https://www.pharmacy180.com/article/overall-nitrogen-metabolism-1937/
HOMD :: SEQF3500HOMD :: SEQF3500
type I glutamate--ammonia ligase. 315. SEQF3500,VSEA01000013.1. TYB19786.1 jb [NA] [AA] 1284/427. 57934-56651. adhesin. ... bifunctional aspartate kinase/homoserine dehydrogenase I. 304. SEQF3500,VSEA01000013.1. TYB19775.1 jb [NA] [AA] 1389/462. 49039 ... tryptophan--tRNA ligase. 344. SEQF3500,VSEA01000012.1. TYB19815.1 jb [NA] [AA] 645/214. 32950-32306. 3%2C4-dihydroxy-2-butanone ...
https://homd.org/genome/explorer?gid=SEQF3500&anno=ncbi&page=2
SMPDBSMPDB
Aspartate. aminotransferase,. cytoplasmic. Nitric oxide. synthase, brain. Bifunctional. glutamate/proline-. -tRNA ligase. ... ammonia],. mitochondrial. Glutamate. dehydrogenase. 1,. mitochondrial. Ornithine. aminotransferase,. mitochondrial. Delta-1-. ... ligase,. mitochondrial. Glycine. amidinotransferase,. mitochondrial. Guanidinoacetate. N-. methyltransferase. Creatine kinase. ...
https://smpdb.ca/view/SMP0000507?highlight%5Bcompounds%5D%5B%5D=DB00148&highlight%5Bproteins%5D%5B%5D=DB00148
Intestinal Metabolic Bromhidrosis Syndrome AllianceIntestinal Metabolic Bromhidrosis Syndrome Alliance
Low potassium (ammonia impairs potassium uptake indirectly by binding to the potassium receptors) ... A possible unknown gene encoding an isovalerate CoA ligase Important is the aspect that e.g. the ACSM2B is also involved in ... Reducing the dietary amount of glutamine, glutamate, aspartate, lysine and ornithine *. Reducing the uptake of calcium ... Elevations in various amino acids related to the ammonia degradation have been found with transitive hyperammonemia. This ...
https://www.imbs-alliance.org/en-GB
MIR4653 3PMIR4653 3P
glutamate-ammonia ligase [Source:HGN.... NM_001033056. 2752. GLUL. glutamate-ammonia ligase [Source:HGN.... ... aspartate beta-hydroxylase [Source:H.... NM_001167674. 253559. CADM2. cell adhesion molecule 2 [Source:HGN.... ...
https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/MIR4653_3P.html
Amino acids in rat neostriatum: Alteration by kainic acid lesion<...
Glutamate-Ammonia Ligase Medicine & Life Sciences 48% * Glutamine Medicine & Life Sciences 37% ... The large decrease in glutamate and aspartate is consistent with hypotheses concerning the intraneuronal localization of a ... The large decrease in glutamate and aspartate is consistent with hypotheses concerning the intraneuronal localization of a ... The large decrease in glutamate and aspartate is consistent with hypotheses concerning the intraneuronal localization of a ...
https://scholars.mssm.edu/en/publications/amino-acids-in-rat-neostriatum-alteration-by-kainic-acid-lesion-2
Metabolites | Free Full-Text | Modelling hCDKL5 Heterologous Expression in BacteriaMetabolites | Free Full-Text | Modelling hCDKL5 Heterologous Expression in Bacteria
... l-aspartate. rxn00285. Citrate cycle (TCA cycle). Succinate-CoA ligase (ADP forming). ATP + CoA + succinate =, ADP + phosphate ... The 11 gene-encoded reactions included the reactions involved in histidine biosynthesis and an ammonia transporter. The ... ATPL-aspartate 4-phosphotransferase. ATP + l-aspartate =, ADP + 4-phospho-l-aspartate. ... and its subsequent conversion to 4-phospho-L-aspartate and l-aspartate-4-semialdehyde (Figure 4B), catalysed by ATPL-aspartate- ...
https://www.mdpi.com/2218-1989/11/8/491
List of EC numbers (EC 2)List of EC numbers (EC 2)
glutamate-ammonia-ligase) adenylyltransferase. *: N-acylneuraminate cytidylyltransferase. *: glucuronate-1-phosphate ... aspartate kinase. *: now EC 6.3.4.16. *: formate kinase. *: butyrate kinase. *: acetylglutamate kinase. *: now EC 6.3.5.5. *: ... ammonia kinase. *: phosphoenolpyruvate-protein phosphotransferase. *: agmatine kinase. *: now EC 2.7.13.1. *: now EC 2.7.13.2. ... List of EC numbers (EC 6) - This list contains a list of EC numbers for the sixth group, EC 6, ligases, placed in numerical ...
https://en-academic.com/dic.nsf/enwiki/2736422
Lenalidomide (Teva Pharmaceuticals, Inc.): FDA Package Insert, Page 6Lenalidomide (Teva Pharmaceuticals, Inc.): FDA Package Insert, Page 6
... or any aspartate transaminase greater than ULN) did not influence the disposition of lenalidomide. No pharmacokinetic data is ... a component of a cullin ring E3 ubiquitin ligase enzyme complex. In vitro , in the presence of drug, substrate proteins ( ... and strong ammonia solution. ...
https://medlibrary.org/lib/rx/meds/lenalidomide/page/6/
Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in...Time-resolved multi-omics analysis reveals the role of nutrient stress-induced resource reallocation for TAG accumulation in...
Glucose and ammonia in the medium, mycelial dry weigh and fatty acid methyl esters (FAME) were determined as described ... 4c). These proteins are mainly involved in glycine, serine and threonine, alanine, aspartate and glutamate, arginine and ... Zheng N, Shabek N. Ubiquitin ligases: structure, function, and regulation. Annu Rev Biochem. 2017;86:129-57. ... Nitrogen stress studies proceeded in 7.5 L-fermentation tanks containing 4.0 L Kendrick broth with ammonia as the nitrogen ...
https://biotechnologyforbiofuels.biomedcentral.com/articles/10.1186/s13068-020-01757-1
YOR184W 2167.216480 INESSENTIAL SER1 phosphoserine transaminase,phosphoserine aminotransferaseYOR184W 2167.216480 INESSENTIAL SER1 phosphoserine transaminase,phosphoserine aminotransferase
... aspartate--tRNA ligase, mitochondrion YER182W -0.456649 INESSENTIAL biological_process unknown, molecular_function unknown, ... 2.448005 INESSENTIAL MEP2 Ammonia transport protein, transport, YDR183W 2.431624 INESSENTIAL PLP1 Phosducin-Like Protein, ... YER052C 510.712176 INESSENTIAL HOM3 Aspartate kinase (L-aspartate 4-P-transferase) (EC 2.7.2.4),aspartate kinase, YNL046W ... component unknown YLR027C 61.250510 INESSENTIAL AAT2 aspartate aminotransferase, cytosolic, aspartate catabolism*, aspartate ...
https://genomics.lbl.gov/YeastFitnessData/websitefiles/47_minimal-media_sen.txt
Genome-scale metabolic analysis of Clostridium thermocellum for bioethanol production | BMC Systems Biology | Full TextGenome-scale metabolic analysis of Clostridium thermocellum for bioethanol production | BMC Systems Biology | Full Text
We did, however, add a reaction for succinate:CoA ligase, based on the fact that succinate has been reported as a metabolic ... In addition to the carbon source, the in silico minimal medium used for simulations contained water (h2o), ammonia (nh4), ... excess carbon is relieved by an increase in the production of aspartate to 8.48 mmol gDW-1 hr-1 (see Additional file 1). With ... CoA ligase. There was no clear genetic evidence for these genes, although similarity searches produced some probable reciprocal ...
https://bmcsystbiol.biomedcentral.com/articles/10.1186/1752-0509-4-31
SMPDBSMPDB
Ammonia Recycling. *Arbekacin Action Pathway. *Aspartate Metabolism. *Azithromycin Action Pathway. *Canavan Disease ... and ubiquitin ligase (Fbs). They are thought to recognize high-mannose-type glycans with subtly different structures. Mannose- ... Aspartic acid (Asp, D), also known as aspartate, the name of its anion, is one of the 20 natural proteinogenic amino acids ... Interestingly, methylamine and ammonia levels are reciprocally controlled by a semicarbazide-sensitive amine oxidase activity ...
https://pathman.smpdb.ca/compounds?limit=20&page=6&sort_by=name.alphabetical&sort_order=asc&species_id=1&species_name=Homo+sapiens
AsparagineGlutamateEnzymesSynthaseEnzyme that catalyzesGlutamineProteinMethylOxaloacetateThreonineNitrogenLevelsDiphthine-ammoniAlanineFumarateToxic ammoniaGlutamineCarbon-nitrogen bondsEnzymeTRNAArginineAcidSubstrateCompoundsSodiumActivityReactionNamesGroup
Asparagine3
  • Asparagine helps to break down toxic ammonia within cells, is important for protein modification, and is needed for making a certain molecule that transmits signals in the brain (a neurotransmitter). (medlineplus.gov)
  • An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP . (bvsalud.org)
  • In the asparagine synthetase reaction, ATP is used to activate aspartate, forming beta-aspartyl-AMP. (smpdb.ca)
Glutamate6
  • glutamate-ammonia ligase [Source:HGN. (gsea-msigdb.org)
  • The high affinity uptake of choline by synaptosomal preparations of lesioned striatum was decreased by 70% compared to controls whereas that of glutamate/aspartate was either unchanged or somewhat increased on a per mg protein basis. (mssm.edu)
  • The unchanging glutamine levels and increase in glutamine synthetase activity are consistent with the widespread gliosis and the lack of change in glutamate/aspartate high affinity uptake is consistent with a sparing of afferent terminals. (mssm.edu)
  • The large decrease in glutamate and aspartate is consistent with hypotheses concerning the intraneuronal localization of a major pool of these amino acids, especially in GABAergic neurons. (mssm.edu)
  • The enzyme transfers the amino group from glutamate to oxaloacetate producing alpha-ketoglutarate and aspartate. (smpdb.ca)
  • Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. (lookformedical.com)
Enzymes3
  • Le nom courant des enzymes de type ligase inclut souvent le terme « ligase » comme l' ADN ligase du phage T4 utilisée pour structurer des fragments d' ADN . (wikipedia.org)
  • Attention cependant à ne pas confondre les enzymes synthétases avec les enzymes synthases (qui sont toutes deux des enzymes du groupe des ligases). (wikipedia.org)
  • Les ligases sont classées EC 6 dans la nomenclature EC des enzymes. (wikipedia.org)
Synthase1
  • En fait la synthase forme et défait les doubles liaisons d'une protéine. (wikipedia.org)
Enzyme that catalyzes1
  • An enzyme that catalyzes the conversion of L-tryptophan and water to indole, pyruvate, and ammonia. (lookformedical.com)
Glutamine1
  • EC 6.3.5 Carbone-Azote Ligases avec Glutamine comme Amido-N-Donneur. (wikipedia.org)
Protein1
  • E3 (a ligase) identifies the protein to be degraded and interacts with E2-Ub. (pharmacy180.com)
Methyl1
  • There are well known further players such as carboxylates (e.g. butyrate, isovalerate), amines, sulfuric compounds, ammonia, methyl mercaptan and indole to name some of them. (imbs-alliance.org)
Oxaloacetate1
  • Oxaloacetate is converted to aspartate using a transaminase enzyme. (smpdb.ca)
Threonine1
  • Threonine catabolism in mammals appears to be due primarily (70-80%) to the activity of threonine dehydrogenase (EC 1.1.1.103) that oxidizes threonine to 2-amino-3-oxobutyrate, which forms glycine and acetyl CoA, whereas threonine dehydratase (EC 4.2.1.16) that catabolizes threonine into 2-oxobutyrate and ammonia, is significantly less active. (smpdb.ca)
Nitrogen1
  • Nitrogen leaves the body as urea, ammonia, and other products derived from amino acid metabolism. (pharmacy180.com)
Levels1
  • Interestingly, methylamine and ammonia levels are reciprocally controlled by a semicarbazide-sensitive amine oxidase activity that deaminates methylamine to formaldehyde with the production of ammonia and hydrogen peroxide. (smpdb.ca)
Diphthine-ammoni1
  • EC 6.3.2.22: Now EC 6.3.1.14 , diphthine-ammonia ligase. (wikibedia.ru)
Alanine1
  • This enzyme participates in alanine and aspartate metabolism and nitrogen metabolism . (wikipedia.org)
Fumarate2
  • Hence, this enzyme has one substrate , L-aspartate , and two products , fumarate and NH 3 . (wikipedia.org)
  • The systematic name of this enzyme class is L-aspartate ammonia-lyase (fumarate-forming) . (wikipedia.org)
Toxic ammonia2
  • Asparagine helps to break down toxic ammonia within cells, is important for protein modification, and is needed for making a certain molecule that transmits signals in the brain (a neurotransmitter). (medlineplus.gov)
  • Legal Disclaimer Glutamic acid is also important for energy production, protecting the immune system, removing toxic ammonia from the body and supporting muscle growth and function. (landcert.com)
Glutamine3
  • In pathways I or II, aspartate is amidated directly, with glutamine or ammonia as the nitrogen source. (lbl.gov)
  • Individuals with HHH syndrome should be maintained on an age-appropriate protein-restricted diet, citrulline supplementation, and sodium phenylbutyrate to maintain plasma concentrations of ammonia, glutamine, arginine, and essential amino acids within normal range. (nih.gov)
  • Attention to subtle changes in mood, behavior, and eating and/or the onset of vomiting, which may suggest that plasma concentrations of glutamine and ammonia are increasing. (nih.gov)
Carbon-nitrogen bonds1
  • This enzyme belongs to the family of lyases , specifically ammonia lyases, which cleave carbon-nitrogen bonds. (wikipedia.org)
Enzyme2
  • An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP. (nih.gov)
  • Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. (nih.gov)
TRNA2
  • In pathway III, aspartate is ligated to tRNA(Asn) and then amidated to Asn-tRNA(Asn). (lbl.gov)
  • EC 6.1.1.28: proline/cysteine-tRNA ligase. (wikibedia.ru)
Arginine1
  • Of primary importance is the use of established protocols to rapidly control hyperammonemic episodes by discontinuation of protein intake, intravenous infusion of glucose and, as needed, infusion of supplemental arginine and the ammonia removal drugs sodium benzoate and sodium phenylacetate. (nih.gov)
Acid1
  • Routine assessment of plasma ammonia concentration, plasma and urine amino acid concentrations, urine organic acids, and urine orotic acid based on age and history of compliance and metabolic control. (nih.gov)
Substrate1
  • An important step in the proteolytic cascade is specific recognition of the substrate by one of many ubiquitin ligases, E3s, which is followed by generation of the polyubiquitin degradation signal. (pharmaceuticalintelligence.com)
Compounds1
  • A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (lookformedical.com)
Sodium1
  • Fluorescence characters from the powdered seed The drug natural powder was used and treated with different chemical reagents such as for example sulphuric acidity, hydrochloric acidity, 5% iodine option, 50% ferric chloride, 10% sodium hydroxide and ammonia option, business lead Acetate and the color attained was visualized under brief UV light (254 nm) and longer UV light (366 nm) within an UV chamber. (dactolisib.info)
Activity1
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
Reaction1
  • The reaction is the basis of the industrial synthesis of aspartate. (wikipedia.org)
Names1
  • Other names in common use include aspartase , fumaric aminase , L-aspartase , and L-aspartate ammonia-lyase . (wikipedia.org)
Group1
  • This list contains a list of EC numbers for the sixth group, EC 6 , ligases , placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology . (wikibedia.ru)