Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.
The 4-aminomethyl form of VITAMIN B 6. During transamination of amino acids, PYRIDOXAL PHOSPHATE is transiently converted into pyridoxamine phosphate.
A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.
Intracellular fluid from the cytoplasm after removal of ORGANELLES and other insoluble cytoplasmic components.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.
An enzyme that catalyzes the conversion of L-TYROSINE and 2-oxoglutarate to 4-hydroxyphenylpyruvate and L-GLUTAMATE. It is a pyridoxal-phosphate protein. L-PHENYLALANINE is hydroxylated to L-tyrosine. The mitochondrial enzyme may be identical with ASPARTATE AMINOTRANSFERASES (EC 2.6.1.1.). Deficiency of this enzyme may cause type II Tyrosinemia (see TYROSINEMIAS). EC 2.6.1.5.
This is the active form of VITAMIN B 6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (PYRIDOXAMINE).
An enzyme that catalyzes the conversion of carbamoyl phosphate and L-aspartate to yield orthophosphate and N-carbamoyl-L-aspartate. (From Enzyme Nomenclature, 1992) EC 2.1.3.2.
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
A set of opposing, nonequilibrium reactions catalyzed by different enzymes which act simultaneously, with at least one of the reactions driven by ATP hydrolysis. The results of the cycle are that ATP energy is depleted, heat is produced and no net substrate-to-product conversion is achieved. Examples of substrate cycling are cycling of gluconeogenesis and glycolysis pathways and cycling of the triglycerides and fatty acid pathways. Rates of substrate cycling may be increased many-fold in association with hypermetabolic states resulting from severe burns, cold exposure, hyperthyroidism, or acute exercise.
A group of compounds that are derivatives of phenylpyruvic acid which has the general formula C6H5CH2COCOOH, and is a metabolite of phenylalanine. (From Dorland, 28th ed)
A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the transfer amino group from L-TRYPTOPHAN to 2-oxoglutarate in order to generate indolepyruvate and L-GLUTAMATE.
A PYRIDOXAL PHOSPHATE containing enzyme that catalyzes the reversible transamination of branched-chain AMINO ACIDS to 2-oxoglutarate.
A pyridoxal-phosphate protein that catalyzes the conversion of L-tyrosine to tyramine and carbon dioxide. The bacterial enzyme also acts on 3-hydroxytyrosine and, more slowly, on 3-hydroxyphenylalanine. (From Enzyme Nomenclature, 1992) EC 4.1.1.25.
A broad-spectrum excitatory amino acid antagonist used as a research tool.
An enzyme that converts brain gamma-aminobutyric acid (GAMMA-AMINOBUTYRIC ACID) into succinate semialdehyde, which can be converted to succinic acid and enter the citric acid cycle. It also acts on beta-alanine. EC 2.6.1.19.
Amino acids which have a branched carbon chain.
Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenases, glutamate dehydrogenase, aspartate aminotransferase and alanine aminotransferase in nervous tissues from vertebrates and invertebrates. (1/2887)

1. The activities of citrate synthase and NAD+-linked and NADP+-linked isocitrate dehydrogenases were measured in nervous tissue from different animals in an attempt to provide more information about the citric acid cycle in this tissue. In higher animals the activities of citrate synthase are greater than the sum of activities of the isocitrate dehydrogenases, whereas they are similar in nervous tissues from the lower animals. This suggests that in higher animals the isocitrate dehydrogenase reaction is far-removed from equilibrium. If it is assumed that isocitrate dehydrogenase activities provide an indication of the maximum flux through the citric acid cycle, the maximum glycolytic capacity in nervous tissue is considerably greater than that of the cycle. This suggest that glycolysis can provide energy in excess of the aerobic capacity of the tissue. 2. The activities of glutamate dehydrogenase are high in most nervous tissues and the activities of aspartate aminotransferase are high in all nervous tissue investigated. However, the activities of alanine aminotransferase are low in all tissues except the ganglia of the waterbug and cockroach. In these insect tissues, anaerobic glycolysis may result in the formation of alanine rather than lactate.  (+info)

Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. (2/2887)

We eliminated type beta transforming growth factor (TGF-beta) signaling by adenovirus-mediated local expression of a dominant-negative type II TGF-beta receptor (AdCATbeta-TR) in the liver of rats treated with dimethylnitrosamine, a model of persistent liver fibrosis. In rats that received a single application of AdCATbeta-TR via the portal vein, liver fibrosis as assessed by histology and hydroxyproline content was markedly attenuated. All AdCATbeta-TR-treated rats remained alive, and their serum levels of hyaluronic acid and transaminases remained at low levels, whereas all the AdCATbeta-TR-untreated rats died of liver dysfunction. The results demonstrate that TGF-beta does play a central role in liver fibrogenesis and indicate clearly in a persistent fibrosis model that prevention of fibrosis by anti-TGF-beta intervention could be therapeutically useful.  (+info)

Enrichment of canalicular membrane with cholesterol and sphingomyelin prevents bile salt-induced hepatic damage. (3/2887)

These studies were undertaken to characterize the role of plasma membrane cholesterol in canalicular secretory functions and hepatocyte integrity against intravenous taurocholate administration. Cholesterol and sphingomyelin concentrations and cholesterol/phospholipid ratios were significantly increased in canalicular membranes of diosgenin-fed rats, suggesting a more resistant structure against solubilization by taurocholate. During taurocholate infusion, control rats had significantly decreased bile flow, whereas diosgenin-fed animals maintained bile flow. Maximal cholesterol output increased by 176% in diosgenin-fed rats, suggesting an increased precursor pool of biliary cholesterol in these animals. Maximal phospholipid output only increased by 43% in diosgenin-fed rats, whereas bile salt output remained at control levels. The kinetics of glutamic oxalacetic transaminase, lactic dehydrogenase, and alkaline phosphatase activities in bile showed a significantly faster release in control than in diosgenin-fed rats. After 30 min of intravenous taurocholate infusion, necrotic hepatocytes were significantly increased in control animals. Preservation of bile secretory functions and hepatocellular cytoprotection by diosgenin against the intravenous infusion of toxic doses of taurocholate was associated with an increased concentration of cholesterol and sphingomyelin in the canalicular membrane. The increase of biliary cholesterol output induced by diosgenin was correlated to the enhanced concentration of cholesterol in the canalicular membrane.  (+info)

Phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. (4/2887)

We conducted a phase I and pharmacokinetic study of the topoisomerase II catalytic inhibitor fostriecin. Fostriecin was administered intravenously over 60 min on days 1-5 at 4-week intervals. Dose was escalated from 2 mg m(-2) day(-1) to 20 mg m(-2) day(-1) in 20 patients. Drug pharmacokinetics was analysed with high performance liquid chromatography with UV-detection. Plasma collected during drug administration was tested in vitro for growth inhibition of a teniposide-resistant small-cell lung cancer (SCLC) cell line. The predominant toxicities were elevated liver transaminases (maximum common toxicity criteria (CTC) grade 4) and serum creatinine (maximum CTC grade 2). These showed only a limited increase with increasing doses, often recovered during drug administration and were fully reversible. Duration of elevated alanine-amino transferase (ALT) was dose-limiting in one patient at 20 mg m(-2). Other frequent toxicities were grade 1-2 nausea/vomiting, fever and mild fatigue. Mean fostriecin plasma half-life was 0.36 h (initial; 95% CI, 0-0.76 h) and 1.51 h (terminal; 95% CI, 0.41-2.61 h). A metabolite, most probably dephosphorylated fostriecin, was detected in plasma and urine. No tumour responses were observed, but the plasma concentrations reached in the patients were insufficient to induce significant growth inhibition in vitro. The maximum tolerated dose (MTD) has not been reached, because drug supply was stopped at the 20 mg m(-2) dose level. However, further escalation seems possible and is warranted to achieve potentially effective drug levels. Fostriecin has a short plasma half-life and longer duration of infusion should be considered.  (+info)

Influences of Kupffer cell stimulation and suppression on immunological liver injury in mice. (5/2887)

AIM: To study the possible involvement of Kupffer cells (KC) in immunological liver injury in mice. METHODS: Liver injury was induced by i.v. injection of Bacillus Calmette-Guerin (BCG) 5 x 10(7) viable bacilli followed by i.v. injection of lipopolysaccharides (LPS) 7.5 micrograms to each mouse. Indian ink and silica were i.v. injected to suppress KC and retinol was given po to stimulate KC in these mice. Plasma alanine aminotransferase (AlaAT), aspatate aminotransferase (AspAT), nitric oxide (NO), and liver tissue were examined. RESULTS: Injection of LPS following BCG injection resulted in a remarkable elevation of plasma NO, AlaAT, and AspAT levels, and severe liver damage. The damages were enhanced by the activation of KC with retinol and reduced by suppression of KC with silica and Indian ink. CONCLUSION: The degree of liver injury induced by BCG + LPS is closely correlated with the status of KC, and NO from KC plays an important role in the pathogenesis of the liver damage in mice.  (+info)

Effect of epidermal growth factor on cultured rat hepatocytes poisoned by CCl4. (6/2887)

AIM: To study the effects of epidermal growth factor (EGF) on CCl4-induced primary cultured hepatocytes injury. METHODS: Alanine amino-transferase (AlaAT) and aspartate aminotransferase (AspAT) activities and K+ concentractions were determined by the Auto-biochemistry Assay System. Malondialdehyde (MDA) was determined by thiobarbituric acid method. Radioactivity was determined by liquid scintillometry. Light microscopy and electron microscopy were used. RESULTS: EGF 40 micrograms.L-1 decreased CCl4 (10 mmol.L-1)-induced damages of rat primary cultured hepatocytes by decreasing AlaAT and AspAT leakage and MDA production, and promoted RNA and DNA synthesis, with a high positive correlation between intracellular K+ leakage and DNA syntheses (r = 0.99, P < 0.01). Cytopathological study showed that EGF decreased damage of liver cells. CONCLUSION: EGF maintains the stability of cellular lipid membrane and promotes syntheses of RNA and DNA of hepatocytes, and intracellular K+ transference is a promotor of the message transmission of DNA synthesis.  (+info)

Opposite behavior of two isozymes when refolding in the presence of non-ionic detergents. (7/2887)

GroEL has a greater affinity for the mitochondrial isozyme (mAAT) of aspartate aminotransferase than for its cytosolic counterpart (cAAT) (Mattingly JR Jr, Iriarte A, Martinez-Carrion M, 1995, J Biol Chem 270:1138-1148), two proteins that share a high degree of sequence similarity and an almost identical spatial structure. The effect of detergents on the refolding of these large, dimeric isozymes parallels this difference in behavior. The presence of non-ionic detergents such as Triton X-100 or lubrol at concentrations above their critical micelle concentration (CMC) interferes with reactivation of mAAT unfolded in guanidinium chloride but increases the yield of cAAT refolding at low temperatures. The inhibitory effect of detergents on the reactivation of mAAT decreases progressively as the addition of detergents is delayed after starting the refolding reaction. The rate of disappearance of the species with affinity for binding detergents coincides with the slowest of the two rate-limiting steps detected in the refolding pathway of mAAT. Limited proteolysis studies indicate that the overall structure of the detergent-bound mAAT resembles that of the protein in a complex with GroEL. The mAAT folding intermediates trapped in the presence of detergents can resume reactivation either upon dilution of the detergent below its CMC or by adding beta-cyclodextrin. Thus, isolation of otherwise transient productive folding intermediates for further characterization is possible through the use of detergents.  (+info)

Folate nutriture alters choline status of women and men fed low choline diets. (8/2887)

Choline and folate share methylation pathways and, in studies of rats, were shown to be metabolically inter-related. To determine whether choline status is related to folate intake in humans, we measured the effect of controlled folate depletion and repletion on the plasma choline and phosphatidylcholine concentrations of 11 healthy men (33-46 y) and 10 healthy women (49-63 y) fed low-choline diets in two separate metabolic unit studies. Total folate intake was varied by supplementing low folate (25 and 56 microg/d for men and women, respectively) and low choline (238 and 147 mg/d for men and women, respectively) diets with pteroylglutamic acid for 2-6 wk following folate-depletion periods of 4-5 wk. The low folate/choline intakes resulted in subclinical folate deficiencies; mean plasma choline decreases of 28 and 25% in the men and women, respectively; and a plasma phosphatidylcholine decrease of 26% in the men (P < 0. 05). No functional choline deficiency occurred, as measured by serum transaminase and lipid concentrations. The decreases in choline status measures returned to baseline or higher upon moderate folate repletion and were more responsive to folate repletion than plasma folate and homocysteine. Feeding methionine supplements to the men did not prevent plasma choline depletion, indicating that folate is a more limiting nutrient for these methylation pathways. The results indicate that 1) choline is utilized as a methyl donor when folate intake is low, 2) the de novo synthesis of phosphatidylcholine is insufficient to maintain choline status when intakes of folate and choline are low, and 3) dietary choline is required by adults in an amount > 250 mg/d to maintain plasma choline and phosphatidylcholine when folate intake is low.  (+info)

... prephenate aspartate aminotransferase, and L-aspartate:prephenate aminotransferase. De-Eknamkul W, Ellis BE (1988). " ... In enzymology, an aspartate-prephenate aminotransferase (EC 2.6.1.78) is an enzyme that catalyzes the chemical reaction L- ... The systematic name of this enzyme class is L-arogenate:oxaloacetate aminotransferase. Other names in common use include ... whereas its two products are prephenate and L-aspartate. This enzyme belongs to the family of transferases, specifically the ...
... aspartate aminotransferase 1)". Panteghini M (1990). "Aspartate aminotransferase isoenzymes". Clin. Biochem. 23 (4): 311-9. doi ... Totan A, Greabu M, Totan C, Spinu T (2006). "Salivary aspartate aminotransferase, alanine aminotransferase and alkaline ... Aspartate aminotransferase, cytoplasmic is an enzyme that in humans is encoded by the GOT1 gene. Glutamic-oxaloacetic ... Doyle JM, Schininà ME, Bossa F, Doonan S (1990). "The amino acid sequence of cytosolic aspartate aminotransferase from human ...
... (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or (serum) glutamic oxaloacetic ... Aminotransferase is cleared by sinusoidal cells in the liver. Aspartate transaminase catalyzes the interconversion of aspartate ... Okamoto A, Kato R, Masui R, Yamagishi A, Oshima T, Kuramitsu S (January 1996). "An aspartate aminotransferase from an extremely ... Kondo K, Wakabayashi S, Yagi T, Kagamiyama H (July 1984). "The complete amino acid sequence of aspartate aminotransferase from ...
... inhibits aspartate aminotransferase, another PLP-dependent enzyme, which is an essential part of the malate ... Also, the inhibition of aspartate aminotransferase by aminooxyacetic acid has clinical implications for the treatment of breast ... Moreover, selective inhibition of aspartate aminotransferase with aminooxyacetic acid ameliorated experimental autoimmune ... "Targeting aspartate aminotransferase in breast cancer". Breast Cancer Research. 10 (5): R84. doi:10.1186/bcr2154. PMC 2614520. ...
Mavrides C, Orr W (1975). "Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli". J. Biol. ... Other names in common use include aromatic amino acid aminotransferase, aromatic aminotransferase, and ArAT. This enzyme ... The systematic name of this enzyme class is aromatic-amino-acid:2-oxoglutarate aminotransferase. ...
Aspartate aminotransferase, mitochondrial is an enzyme that in humans is encoded by the GOT2 gene. Glutamic-oxaloacetic ... Guidetti P, Amori L, Sapko MT, Okuno E, Schwarcz R (Jul 2007). "Mitochondrial aspartate aminotransferase: a third kynurenate- ... Furuya E, Yoshida Y, Tagawa K (May 1979). "Interaction of mitochondrial aspartate aminotransferase with negatively charged ... "Entrez Gene: GOT2 glutamic-oxaloacetic transaminase 2, mitochondrial (aspartate aminotransferase 2)". Ford GC, Eichele G, ...
"Cytosolic aspartate aminotransferase inactivating-enzyme from Streptomyces violaceochromogenes". Agricultural and Biological ...
The systematic name of this enzyme class is L-aspartate:phenylpyruvate aminotransferase. This enzyme is also called aspartate- ... phenylpyruvate aminotransferase. Holger Z, Kula MR (1985). "Isolation and characterization of a highly inducible L-aspartate- ... In enzymology, an aspartate-phenylpyruvate transaminase (EC 2.6.1.70) is an enzyme that catalyzes the chemical reaction L- ... the two substrates of this enzyme are L-aspartate and phenylpyruvate, whereas its two products are oxaloacetate and L- ...
... increased levels of an enzyme called aspartate aminotransferase; headache; and infection in the lungs (pneumonia). Trilaciclib ...
Fasella, Paolo; Giartosio, Anna; Hammes, Gordon G. (1966). "The Interaction of Aspartate Aminotransferase with α-Methylaspartic ... He studied the kinetic behavior of various enzymes, including glutamate-aspartate transaminase, hexokinase, and ribonuclease. ...
... aspartate is converted by cytosolic aspartate aminotransferase to oxaloacetate. The net effect of the malate-aspartate shuttle ... by mitochondrial aspartate aminotransferase. Since aspartate is an amino acid, an amino radical needs to be added to the ... aspartate aminotransferase in the mitochondrial matrix and intermembrane space. malate-alpha-ketoglutarate antiporter in the ... glutamate-aspartate antiporter in the inner membrane. The primary enzyme in the malate-aspartate shuttle is malate ...
September 1975). "The primary structure of aspartate aminotransferase from pig heart muscle. Digestion with a proteinase having ...
"Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure". Journal of Molecular Biology ... These reactions are facilitated by transaminases in order to produce aspartate and asparagine from oxaloacetate. Transamination ...
The two common types of aminotransferases are Alanine aminotransferase (ALT) and Aspartate aminotransferase (AST). Booth, ... Glutamate + oxaloacetate ↔ α-ketoglutarate + aspartate Transamination catalyzed by aminotransferase occurs in two stages. In ... The products usually are either alanine, aspartate or glutamate, since their corresponding alpha-keto acids are produced ... For the reaction to complete, aminotransferases require participation of aldehyde containing coenzyme, pyridoxal-5'-phosphate ( ...
It is also a member of the broader aspartate aminotransferase family. Like many other PLP-dependent enzymes, cystathionine γ- ...
The alanine aminotransferase, aspartate aminotransferase and creatine kinase levels may be raised. The gamma- ...
Guidetti P, Amori L, Sapko MT, Okuno E, Schwarcz R (July 2007). "Mitochondrial aspartate aminotransferase: a third kynurenate- ... kynurenine aminotransferase, and L-kynurenine aminotransferase. This enzyme participates in tryptophan metabolism. It employs ... "Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II". Bioscience Reports ... "Substrate specificity and structure of human aminoadipate aminotransferase/kynurenine aminotransferase II". Bioscience Reports ...
The ratio of aspartate aminotransferase to alanine aminotransferase is usually 2 or more. In most cases, the liver enzymes do ... Sorbi D, Boynton J, Lindor KD (1999). "The ratio of aspartate aminotransferase to alanine aminotransferase: potential value in ... and aminotransferases, and onset of jaundice within the last 8 weeks. ...
For example, aspartate aminotransferase converts glutamate and oxaloacetate to alpha-ketoglutarate and aspartate. Other ... Notice that aspartate and glutamate are the principal groups that act as Brønsted bases, and the common references to these as ... Thus for aspartate or glutamate with negative side chains, the terminal amino group is essentially entirely in the charged form ... Aspartate ("aspartic acid", Asp, D, p K a = 4.1 {\displaystyle \mathrm {p} K_{\mathrm {a} }=4.1} ): -O2CCH2− Glutamate (" ...
... elevated levels of the liver enzymes alanine aminotransferase (ALT) and aspartate aminotransferase (AST); and abnormalities in ...
... may cause severe elevations in serum aminotransferases, alanine transaminase (ALT) and aspartate ...
"Structural features of the precursor to mitochondrial aspartate aminotransferase responsible for binding to hsp70". The Journal ...
"Mechanism of action of aspartate aminotransferase proposed on the basis of its spatial structure". Journal of Molecular Biology ... In ATCase such a transfer is written as carbamoyl phosphate + L-aspartate → {\displaystyle \rightarrow } L-carbamoyl aspartate ... Transamination, or the transfer of an amine (or NH2) group from an amino acid to a keto acid by an aminotransferase (also known ... This includes enzymes like transaminase (also known as "aminotransferase"), and a very small number of oximinotransferases and ...
Aspartate aminotransferase to platelet ratio index may be used when cost is an issue. Hepatitis B virus DNA remains in the body ... Carriers of the virus may have chronic hepatitis B, which would be reflected by elevated serum alanine aminotransferase (ALT) ... Chronically infected individuals with persistently elevated serum alanine aminotransferase, a marker of liver damage, and HBV ...
... is an irreversible inhibitor of the aspartate aminotransferase produced by the bacterium Streptomyces sumanensis. Its ...
"Identification of a plant gene encoding glutamate/aspartate-prephenate aminotransferase: the last homeless enzyme of aromatic ... "Three different classes of aminotransferases evolved prephenate aminotransferase functionality in arogenate-competent ... In the absence of glutamate, aspartate can act as the amino donor in the reaction without the need for a different enzyme, but ... Glutamate-Prephanate Aminotransferase catalyzes the reversible reaction shown below: , and its primary purpose is to convert ...
Hsu YC, Tai DI (2011). "Unusually high alanine aminotransferase to aspartate aminotransferase ratio in a patient with ...
The "large" domain contains the PLP binding site, as seen in other PLP-dependent proteins, like aspartate aminotransferase. The ...
Here, the OAA produced by PEPC is transaminated by aspartate aminotransferase to aspartate (ASP) which is the metabolite ... In this variant the OAA produced by aspartate aminotransferase in the bundle sheath is decarboxylated to PEP by PEPCK. The fate ... The first experiments indicating that some plants do not use C3 carbon fixation but instead produce malate and aspartate in the ... either malate or aspartate) in the mesophyll. The organic acids then diffuse through plasmodesmata into the bundle sheath cells ...
"Severe preeclampsia with fulminant and extreme elevation of aspartate aminotransferase and lactate dehydrogenase levels: high ... Elevated serum levels of certain proteins, in particular, LDH, alanine transaminase (ALT) and aspartate transaminase (AST), are ... an aspartate transaminase greater than 70 U/L, and platelets less than 100×109/l. If not all the criteria are present, the ...
The systematic name of this enzyme class is L-alanine:3-oxopropanoate aminotransferase. Other names in common use include beta- ... This enzyme participates in 4 metabolic pathways: alanine and aspartate metabolism, valine, leucine and isoleucine degradation ... Stinson RA, Spencer MS (1969). "Beta alanine aminotransferase (s) from a plant source". Biochem. Biophys. Res. Commun. 34 (1): ... alanine-pyruvate aminotransferase, and beta-alanine-alpha-alanine transaminase. ...
... diaminobutyrate aminotransferase, DABA aminotransferase, DAB aminotransferase, EctB, diaminibutyric acid aminotransferase, and ... L-aspartate 4-semialdehyde + L-glutamate Thus, the two substrates of this enzyme are L-2,4-diaminobutanoate and 2-oxoglutarate ... The systematic name of this enzyme class is L-2,4-diaminobutanoate:2-oxoglutarate 4-aminotransferase. Other names in common use ... include L-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase, 2,4-diaminobutyrate 4-aminotransferase, ...
C and E virus markers among patients with elevated levels of Alanine aminotransferase and Aspartate aminotransferase in Phnom ...
... aspartate aminotransferase, precorrin-8x methylmutase, protoporphyrin IX magnesium chelatase and geranylgeranylglyceryl ...
This enzyme is also called asparagine-keto acid aminotransferase. This enzyme participates in alanine and aspartate metabolism ... The systematic name of this enzyme class is L-asparagine:2-oxo-acid aminotransferase. ...
However, measurement of serum aminotransferase levels alone is not a good marker to determine cholestasis. In up to a third of ... In a later stage of cholestasis aspartate transaminase (AST), alanine transaminase (ALT) and unconjugated bilirubin may be ... Typically, aminotransferase enzymes are localized within hepatocytes and leak across the membrane upon damage. ... McGill MR (2016-12-15). "The past and present of serum aminotransferases and the future of liver injury biomarkers". EXCLI ...
... it has been shown that alpha ketoglutarate dehydrogenase can interact with mitochondrial aspartate aminotransferase to form a ... The three residues in particular that comprise a catalytic triad are histidine (His-195), aspartate (Asp-168), both of which ... The other is found in the cytoplasm, assisting the malate-aspartate shuttle with exchanging reducing equivalents so that malate ... Additionally, the formation of this complex enables glutamate to react with aminotransferase without interfering activity of ...
... determined that the appropriate terminology for AST and ALT are aspartate aminotransferase and alanine aminotransferase. The ... Aminotransferase is cleared by sinusoidal cells in the liver. ALT catalyzes the transfer of an amino group from L-alanine to α- ... Aminotransferase clearance is carried out within the liver by sinusoidal cells. The half-life in the circulation is about 47 ... Aspartate transaminase Liver function tests Karmen A, Wroblewski F, Ladue JS (January 1955). "Transaminase activity in human ...
... aspartate aminotransferase) reached normal or almost optimal values. Patients without observed liver cirrhosis compared to the ... In patients aged 10-20 years, serum concentrations of bilirubin, bile acids and transaminases (alanine aminotransferase, ...
Regarding the organic nitrogen sources used by these bacteria, glutamate and aspartate are among the most common. Hydrogen (H2 ... glutamine oxoglutarate aminotransferase), which incorporate the inorganic ammonia into amino acids. ... glutamate or aspartate as nitrogen source; H2 and CO2 thus obtained can be then used as substrates for photosynthesis. The ...
... the activities of aspartate aminotransferase linearly increased in plasma and decreased plasma insulin content without decrease ...
Other names in common use include D-aspartate transaminase, D-alanine aminotransferase, D-aspartic aminotransferase, D-alanine- ... Sugio S, Petsko GA, Manning JM, Soda K, Ringe D (1995). "Crystal structure of a D-amino acid aminotransferase: how the protein ... Tanizawa K, Masu Y, Asano S, Tanaka H, Soda K (1989). "Thermostable D-amino acid aminotransferase from a thermophilic Bacillus ... Ogawa T, Fukuda M, Sasaoka K (1973). "Occurrence of D-amino acid aminotransferase in pea seedlings". Biochem. Biophys. Res. ...
In the central nervous system it is converted to 7-chlorokynurenic acid by kynurenine aminotransferase in astrocytes. Most of ... "A Randomized Trial of the N-Methyl-d-Aspartate Receptor Glycine Site Antagonist Prodrug 4-Chlorokynurenine in Treatment- ...
... where serum aminotransferase levels are higher than 500 IU/L, and other local causes of hepatitis have been excluded. It is not ... and has a higher than 500 IU/L of the liver enzyme aspartate transaminase. Hepatitis due to drug toxicity, and inherited ...
ALP and GGT levels typically rise with one pattern while aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ... Some bone and heart disorders can lead to an increase in ALP and the aminotransferases, so the first step in differentiating ... The typical liver panel includes blood levels of enzymes found primarily from the liver, such as the aminotransferases (ALT, ...
CAIR + L-Aspartate + ATP → SAICAR + ADP + Pi The eight is catalyzed by adenylosuccinate lyase. SAICAR → AICAR + Fumarate The ... phosphoribosylamine from glutamine and PRPP catalysed by PRPP amino transferase is the regulation point for purine synthesis. ...
9% for placebo), increased aspartate aminotransferase (AST) (23% vs. 14% for placebo; Grade 3-4: 0.5% vs. 0.2% for placebo), ...
... the activation coefficient for the erythrocyte enzyme aspartate aminotransferase, and the urinary excretion of vitamin B6 ...
... alanine aminotransferase increased, alkaline phosphatase increased, anaphylactic reaction, angioneurotic edema, aspartate ... aminotransferase increased, bilirubin increased, glaucoma, hepatotoxicity, hyponatremia, jaundice, orthostatic hypotension ( ...
Rash Alanine aminotransferase increased Aspartate aminotransferase increased Fractures Hematuria Uncommon (0.1-1% frequency): ...
The aspartate aminotransferase (AST) blood test measures the level of the enzyme AST in the blood. ... The aspartate aminotransferase (AST) blood test measures the level of the enzyme AST in the blood. ...
Comparison of the Urinary Excretion of Aspartate Aminotransferase, Lactic Dehydrogenase, Alkaline and Acid Phosphatase and β- ...
Aspartate aminotransferase, cytoplasmic OS=Bos tau... [more]. sp,P13221,AATC_RAT. 1.286e-159. 53.33. Aspartate aminotransferase ... Aspartate aminotransferase, cytoplasmic OS=Gallus ... [more]. sp,P00503,AATC_PIG. 8.935e-161. 53.68. Aspartate aminotransferase ... Aspartate aminotransferase, cytoplasmic [Source:U... [more]. got-2.2. 1.960e-127. 46.55. Aspartate aminotransferase [Source: ... Aspartate aminotransferase [Source:UniProtKB/TrEM... [more]. got-2.1. 1.053e-120. 43.61. Aspartate aminotransferase [Source: ...
LBXSASSI - Aspartate aminotransferase AST (U/L). Variable Name: LBXSASSI. SAS Label: Aspartate aminotransferase AST (U/L). ... Aspartate aminotransferase AST (U/L). Target: Both males and females 12 YEARS - 150 YEARS. Code or Value. Value Description. ... 3. Aspartate Aminotransferase (AST) The DxC800 uses an enzymatic rate method to measure the AST activity in serum or plasma. In ... 4. Aspartate Aminotransferase (AST) AST measurements are used in the diagnosis and treatment of certain types of liver and ...
Elevated alanine aminotransferase or aspartate aminotransferase levels of unknown origin. *Persons who request HBV testing (new ... aspartate aminotransferase/alanine aminotransferase; CBC = complete blood count; HBeAg = hepatitis B e antigen; HBsAg = ... Persons with Elevated ALT or Aspartate Aminotransferase Levels of Unknown Origin. Persons with known chronic liver disease (e.g ... However, persons with persistently elevated ALT or aspartate aminotransferase (AST) levels without a known cause should be ...
Elevated alanine aminotransferase or aspartate aminotransferase levels of unknown origin. *Persons who request HBV testing (new ... aspartate aminotransferase/alanine aminotransferase; CBC = complete blood count; HBeAg = hepatitis B e antigen; HBsAg = ... Persons with Elevated ALT or Aspartate Aminotransferase Levels of Unknown Origin. Persons with known chronic liver disease (e.g ... However, persons with persistently elevated ALT or aspartate aminotransferase (AST) levels without a known cause should be ...
... among which liver injury markers such as alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bile acid ... We recently found that H2-treated rats (HRW and HI) had reduced serum levels of alanine aminotransferase (ALT), aspartate ... aminotransferase (AST), and total bile acid (TBA)24, suggesting that prolonged exposure to H2 could influence liver physiology ...
... alanine aminotransferase, and insulin like growth factor-II appear to be more associated with the amount of breast adipose ... We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were ... alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP), were measured by a certified ... We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were ...
Aspartate aminotransferase (AST). * Alanine aminotransferase (ALT). * Gamma glutamyltransferase (GGT). * Mean corpuscular ...
aspartate aminotransferase. ALT. alanine aminotransferase. ICAM. intercellular cell adhesion molecule. BCL-2. B-cell lymphoma ... reduction in the ionic currents of N-methyl-D-aspartate (NMDA) [189]. However, a clinical study aimed at evaluating the ... that SJW extract reduced paracetamol-elicited rise in plasma concentrations of myeloperoxidase and AST/ALT aminotransferases, ...
Aspartate aminotransferase. 97 U/L. 0-37 U/L. Alanine aminotransferase. 71 U/L. 0-40 U/L. ...
Results: Abnormal LFT at baseline was present in 58% of patients, with a predominant elevation of aspartate aminotransferase ( ... AST) (42%), gamma-glutamyltransferase (GGT) (37%) and alanine aminotransferase (ALT) (27%), hypoalbuminaemia was observed in 33 ...
Alanine aminotransferase (ALT) ,= 1.25 X institutional upper limit of normal (ULN).. *Aspartate aminotransferase (AST) ,= 1.25 ...
ALT, alanine aminotransferase; AST, aspartate aminotransferase; Borrelia, Borrelia burgdorferi sensu lato; CRP, C-reactive ...
Aspartate aminotransferase (AST). * Alanine aminotransferase (ALT). * Gamma glutamyltransferase (GGT). * Mean corpuscular ...
... of patients experienced an aspartate aminotransferase (AST) increase ≥2× ULN, and 1.7% of patients experienced an AST or ALT ... In ExteNET, 10% of patients experienced an alanine aminotransferase (ALT) increase ≥2× ULN, 5% ...
Whats aspartate aminotransferase?. Dr. Foster Carranswered. General Practice 35 years experience ...
Aspartate aminotransferase (AST) ,2 × ULN c. Total bilirubin ,2 × ULN d. Alkaline phosphatase (ALP) ,2 × ULN e. Creatinine ,1.5 ... Screening laboratory values (as measured by the central laboratory): a. Alanine aminotransferase (ALT) ,2 × upper limit of ...
In males of test group 3 (2000 mg/kg bw/d) alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were ... In males of test group 3 (2000 mg/kg bw/d) alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were ... The following parameters were observed: alanine aminotransferase; aspartate aminotransferase; alkaline phosphatase; serum y- ...
Aspartate aminotransferase:(AST) is an enzyme present in the liver and other tissues of the body. ... Aspartate Aminotransferase (AST). 8 to 33 U/L. 10 to 40 U/L. ... Alanine Aminotransferase (ALT). 4 to 36 U/L. 10 to 40 U/L. ... Alanine aminotransferase: (ALT) is an enzyme primarily found in the liver.. *Albumin: is a protein produced in the liver that ...
1. Alanine aminotransferase. 2. Aspartate aminotransferase. 3. Alkaline phosphatase. 4. Serum y-glutamyl transferase. 5. lnorg ... alanine aminotransferase, alkaline phosphatase, cholesterol. 500 mg/kg bw/d:. Statistically significant decrease of ...
ALT: Alanine aminotransferase; AML: α-amylase; AST: Aspartate aminotransferase; DB: Direct bilirubin; Hgb: Hemoglobin; LOS: ... aspartate aminotransferase (AST), alanine aminotransferase (ALT), α-amylase (AML), as well as gamma-glutamyl transpeptidase ( ... Figure 2 Receiver operating characteristic curves of aspartate aminotransferase, α-amylase, and direct bilirubin for hospital ... Increased aspartate aminotransferase and direct bilirubin (DB) levels the day before the OPD as well as the absence of ...
Alanine Aminotransferase (ALT). *Aspartate Aminotransferase (AST). *Lactate Dehydrogenase (LDH). *Creatine Phosphokinase (CPK) ...
AST Aspartate aminotransferase. Chronic (persistent) HCV infection Persistent infection with HCV; characterized by detection of ... Persons with other evidence of liver disease identified by abnormal serum aspartate aminotransferase (AST) levels, which is ... ALT Alanine aminotransferase. Anti-HCV Antibody to HCV that develops in response to HCV infection; detectable in persons with ... persons with persistently abnormal alanine aminotransferase levels. * Prior recipients of transfusions or organ transplants, ...
Serum bilirubin, aspartate aminotransferase (AST), alanine aminotransferase (ALT) * Thyroid-stimulating hormone (TSH) ...
Laboratory Abnormalities -Increased alanine aminotransferase, increased aspartate aminotransferase. Neurological - Peripheral ... alkaline phosphatase and aspartate aminotransferase.. USE IN SPECIFIC POPULATIONS. The following adverse reactions are ...
... aspartate aminotransferase and creatine kinase activities and phosphate concentration). The low magnitude of changes in serum ... Aspartate aminotransferase (U/L). 259 ± 48. 268 ± 56. 244 ± 56. 244 ± 24. 254 ± 35. 253 ± 24. 252 ± 31. 272 ± 35. 224 ± 28. ...
Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and tumor necrosis factor (TNF)‑α were ... Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and TNF-α were determined using ELISAs ... Res, resveratrol; SMA, smooth muscle actin; TNF, tumor necrosis factor; ALT, alanine aminotransferase; AST, aspartate ...
  • Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. (cdc.gov)
  • We also found that the number of completed pregnancies, C-reactive protein, aspartate aminotransferase, and progesterone were more strongly associated with amounts of glandular tissue than adipose tissue, while fat body mass, alanine aminotransferase, and insulin like growth factor-II appear to be more associated with the amount of breast adipose tissue. (hindawi.com)
  • Serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and tumor necrosis factor (TNF)‑α were detected by ELISAs. (spandidos-publications.com)
  • Levels of plasma alanine aminotransferase and aspartate aminotransferase were not significantly altered by the treatment. (cdc.gov)
  • Serum elevations of ALT activity are rarely observed except in parenchymal liver disease, since ALT is a more liver-specific enzyme than aspartate aminotransferase (AST). (cdc.gov)
  • The aspartate aminotransferase (AST) blood test measures the level of the enzyme AST in the blood. (medlineplus.gov)
  • Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. (bvsalud.org)
  • Aspartato aminotransferasa localizada en las MITOCONDRIAS. (bvsalud.org)
  • Violin plots show distribution of expression levels for Aspartate aminotransferase (SMED30006095) in cells (dots) of each of the 12 neoblast clusters. (stowers.org)
  • Violin plots show distribution of expression levels for Aspartate aminotransferase (SMED30006095) in cells (dots) of each of the 10 clusters of sub-leathally irradiated X1 and X2 cells. (stowers.org)
  • An aspartate aminotransferase found in MITOCHONDRIA. (bvsalud.org)

No images available that match "aspartate aminotransferases"