Asialoglycoprotein Receptor: A C-type lectin that is a cell surface receptor for ASIALOGLYCOPROTEINS. It is found primarily in the LIVER where it mediates the endocytosis of serum glycoproteins.Asialoglycoproteins: Endogenous glycoproteins from which SIALIC ACID has been removed by the action of sialidases. They bind tightly to the ASIALOGLYCOPROTEIN RECEPTOR which is located on hepatocyte plasma membranes. After internalization by adsorptive ENDOCYTOSIS they are delivered to LYSOSOMES for degradation. Therefore receptor-mediated clearance of asialoglycoproteins is an important aspect of the turnover of plasma glycoproteins. They are elevated in serum of patients with HEPATIC CIRRHOSIS or HEPATITIS.OrosomucoidFetuins: A family of calcium-binding alpha-globulins that are synthesized in the LIVER and play an essential role in maintaining the solubility of CALCIUM in the BLOOD. In addition the fetuins contain aminoterminal cystatin domains and are classified as type 3 cystatins.Receptors, Cell Surface: Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.Receptors, Immunologic: Cell surface molecules on cells of the immune system that specifically bind surface molecules or messenger molecules and trigger changes in the behavior of cells. Although these receptors were first identified in the immune system, many have important functions elsewhere.Butea: A plant genus of the family FABACEAE that contains butrin and isobutrin.Galactose Oxidase: An enzyme that oxidizes galactose in the presence of molecular oxygen to D-galacto-hexodialdose. It is a copper protein. EC 1.1.3.9.Endocytosis: Cellular uptake of extracellular materials within membrane-limited vacuoles or microvesicles. ENDOSOMES play a central role in endocytosis.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Acetylgalactosamine: The N-acetyl derivative of galactosamine.Technetium Tc 99m Aggregated Albumin: A gamma-emitting radionuclide imaging agent used for the diagnosis of diseases in many tissues, particularly in cardiovascular and cerebral circulation.Technetium Tc 99m Pentetate: A technetium imaging agent used in renal scintigraphy, computed tomography, lung ventilation imaging, gastrointestinal scintigraphy, and many other procedures which employ radionuclide imaging agents.Lysosomes: A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Galactose: An aldohexose that occurs naturally in the D-form in lactose, cerebrosides, gangliosides, and mucoproteins. Deficiency of galactosyl-1-phosphate uridyltransferase (GALACTOSE-1-PHOSPHATE URIDYL-TRANSFERASE DEFICIENCY DISEASE) causes an error in galactose metabolism called GALACTOSEMIA, resulting in elevations of galactose in the blood.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Kinetics: The rate dynamics in chemical or physical systems.Guanosine Diphosphate Fucose: A nucleoside diphosphate sugar formed from GDPmannose, which provides fucose for lipopolysaccharides of bacterial cell walls, and for blood group substances and other glycoproteins.Lectins: Proteins that share the common characteristic of binding to carbohydrates. Some ANTIBODIES and carbohydrate-metabolizing proteins (ENZYMES) also bind to carbohydrates, however they are not considered lectins. PLANT LECTINS are carbohydrate-binding proteins that have been primarily identified by their hemagglutinating activity (HEMAGGLUTININS). However, a variety of lectins occur in animal species where they serve diverse array of functions through specific carbohydrate recognition.Hepatoblastoma: A malignant neoplasm occurring in young children, primarily in the liver, composed of tissue resembling embryonal or fetal hepatic epithelium, or mixed epithelial and mesenchymal tissues. (Stedman, 25th ed)Tosylphenylalanyl Chloromethyl Ketone: An inhibitor of Serine Endopeptidases. Acts as alkylating agent and is known to interfere with the translation process.Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)Galactosides: Glycosides formed by the reaction of the hydroxyl group on the anomeric carbon atom of galactose with an alcohol to form an acetal. They include both alpha- and beta-galactosides.Coated Pits, Cell-Membrane: Specialized regions of the cell membrane composed of pits coated with a bristle covering made of the protein CLATHRIN. These pits are the entry route for macromolecules bound by cell surface receptors. The pits are then internalized into the cytoplasm to form the COATED VESICLES.Polylysine: A peptide which is a homopolymer of lysine.Liver Neoplasms: Tumors or cancer of the LIVER.Carcinoma, Hepatocellular: A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested.alpha-Fetoproteins: The first alpha-globulins to appear in mammalian sera during FETAL DEVELOPMENT and the dominant serum proteins in early embryonic life.Hepatocytes: The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.Superior Sagittal Sinus: The long large endothelium-lined venous channel on the top outer surface of the brain. It receives blood from a vein in the nasal cavity, runs backwards, and gradually increases in size as blood drains from veins of the brain and the DURA MATER. Near the lower back of the CRANIUM, the superior sagittal sinus deviates to one side (usually the right) and continues on as one of the TRANSVERSE SINUSES.Cathepsin L: A ubiquitously-expressed cysteine protease that plays an enzymatic role in POST-TRANSLATIONAL PROTEIN PROCESSING of proteins within SECRETORY GRANULES.Glioblastoma: A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Myelodysplastic Syndromes: Clonal hematopoietic stem cell disorders characterized by dysplasia in one or more hematopoietic cell lineages. They predominantly affect patients over 60, are considered preleukemic conditions, and have high probability of transformation into ACUTE MYELOID LEUKEMIA.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Atlases as Topic: Collections of illustrative plates, charts, etc., usually with explanatory captions.Raptors: BIRDS that hunt and kill other animals, especially higher vertebrates, for food. They include the FALCONIFORMES order, or diurnal birds of prey, comprised of EAGLES, falcons, HAWKS, and others, as well as the STRIGIFORMES order, or nocturnal birds of prey, which includes OWLS.Anatomy, Artistic: The study of the structures of organisms for applications in art: drawing, painting, sculpture, illustration, etc.Hawks: Common name for many members of the FALCONIFORMES order, family Accipitridae, generally smaller than EAGLES, and containing short, rounded wings and a long tail.Ulnar Artery: The larger of the two terminal branches of the brachial artery, beginning about one centimeter distal to the bend of the elbow. Like the RADIAL ARTERY, its branches may be divided into three groups corresponding to their locations in the forearm, wrist, and hand.Education, Graduate: Studies beyond the bachelor's degree at an institution having graduate programs for the purpose of preparing for entrance into a specific field, and obtaining a higher degree.Physical Fitness: The ability to carry out daily tasks and perform physical activities in a highly functional state, often as a result of physical conditioning.Pennisetum: A plant genus of the family POACEAE. The seed is one of the millets used in EDIBLE GRAIN. It contains vitexin. The common name of buffelgrass is also used for CENCHRUS.Sialic Acids: A group of naturally occurring N-and O-acyl derivatives of the deoxyamino sugar neuraminic acid. They are ubiquitously distributed in many tissues.Cenchrus: A plant genus of the family POACEAE. The common name of buffelgrass is also used for PENNISETUM.Carbohydrates: The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
What is asialoglycoprotein receptor? Meaning of asialoglycoprotein receptor medical term. What does asialoglycoprotein receptor ... Looking for online definition of asialoglycoprotein receptor in the Medical Dictionary? asialoglycoprotein receptor explanation ... for clearance by the asialoglycoprotein receptor of the liver between asialylated intestinal ALP and asialoglycoproteins can ... This study evaluated the usefulness of asialoglycoprotein receptor scintigraphy with [sup.. Asialoglycoprotein receptor ...
A C-type lectin that is a cell surface receptor for ASIALOGLYCOPROTEINS. It is found primarily in the LIVER where it mediates ... Receptor, Hepatic Asialoglycoprotein; Receptors, Asialoglycoprotein; Receptors, Asialoorosomucoid; Asialoglycoprotein Receptors ... Hepatic Asialoglycoprotein Receptor; Hepatic Lectin; Liver Carbohydrate-Binding Protein; Receptor, Asialoglycoprotein; Receptor ... Asialoglycoprotein Receptor. Subscribe to New Research on Asialoglycoprotein Receptor A C-type lectin that is a cell surface ...
Receptors, Immunologic/metabolism*. *Reference Values. Substances. *Asialoglycoprotein Receptor. *Asialoglycoproteins. *Ligands ... Effect of chronic ethanol administration on total asialoglycoprotein receptor content and intracellular processing of ... In addition to a decreased number of intracellular receptors, an impairment in intracellular processing of receptor-ligand ... These results indicate that chronic ethanol administration decreases ligand binding due to a decreased number of receptors and ...
When the COOH terminus of the rat liver receptor is aligned with the corresponding portions of the chicken liver receptor, the ... Sequence homology between residues 50-79 and residues 121-150 of the rat receptor suggests that the additional length of this ... The overall arrangement of the polypeptide is similar to the chicken receptor for asialoagalactoglycoproteins; it consists of ... there must be at least two genes coding for receptor polypeptides. RHL-2 and RHL-3 may differ in their extent of ...
What is asialoglycoprotein? Meaning of asialoglycoprotein medical term. What does asialoglycoprotein mean? ... Looking for online definition of asialoglycoprotein in the Medical Dictionary? asialoglycoprotein explanation free. ... Asialoglycoprotein receptor. *asialoglycoprotein receptor 1. *asialoglycoprotein receptor 2. *Asialoglycoproteins. *asialorrhea ... This study evaluated the usefulness of asialoglycoprotein receptor scintigraphy with [sup.. Asialoglycoprotein receptor ...
... the potential to directly contribute to liver injury and to the distortion of the hepatocyte clearance of asialoglycoproteins ... Diao, Jingyu (1996) Pathogenesis of liver injury : virus-induced autoantibody response against asialoglycoprotein receptor in ... Pathogenesis of liver injury : virus-induced autoantibody response against asialoglycoprotein receptor in woodchuck (Marmota ... Pathogenesis of liver injury : virus-induced autoantibody response against asialoglycoprotein receptor in woodchuck (Marmota ...
ASGR: asialoglycoprotein receptor, CD95L: CD95 ligand, conc.: concentration, FcRn: neonatal Fc receptor, fu: fraction unbound, ... If the sialic acid is removed or missing to expose the galactose residues beneath, these "asialoglycoproteins" are eliminated ... the genes that encode the asialoglycoprotein receptor (Ashwell receptor), are expressed in peripheral blood monocytes and show ... Figure 2. Asialoglycoprotein receptor (ASGR) mediated clearance of asunercept as a function of the sialic acid:glycan ratio of ...
Function of Asialoglycoprotein Receptor of Hepatocytes in Patients with Wilsons Disease. (1994) ... Intracellular traffic of asialoglycoproteins depends on vacuolar pH in polarized isolated rat hepatocyte couplets (1999) ... Ultrastructure of Intracellular Membranous System and Intracellular Transport of Asialoglycoproteins in Rat Hepatocytes (1992) ...
... imaging with a radiolabeled asialoglycoprotein analog, Technetium-99m-diethylenetriaminepentaacetic acid-galactosyl-human serum ... Evaluation of GalNAc-siRNA Conjugate Activity in Pre-clinical Animal Models with Reduced Asialoglycoprotein Receptor Expression ... Hepatic lobar differences in progression of chronic liver disease: correlation of asialoglycoprotein scintigraphy and hepatic ... correlation of asialoglycoprotein scintigraphy and hepatic functional reserve.}, author={Shigenobu Matsuzaki and Masahiko Onda ...
... receptor and the LDL receptor-related protein (LRP)/alpha 2-macroglobulin receptor, have been found to have a role in the ... CHYLOMICRON REMNANT AND ASIALOGLYCOPROTEIN METABOLISM ARE INDEPENDENT LIPIDS Cooper, A. D., Coleman, D. 1985; 20 (10): 664-667 ... Because of the considerable similarities between the hepatic metabolism of chylomicron remnants and asialoglycoproteins, the ... thus demonstrating that the induced rat lipoprotein receptor was related to the LDL receptor of other species. This receptor is ...
... receptor is a transmembrane hepatocellular surface carbohydrate binding glycoproteins lacking terminal sialic acid… ... Recombinant protein of human asialoglycoprotein receptor 1 (ASGR1). Human. > 80 % Preparation: Recombint protein was captured ... asialoglycoproteins). Characterization of the ASGP receptor revealed its functional role in the binding, internalization and ... Lenti ORF particles, Asgr1 (Myc-DDK-tagged) - Mouse asialoglycoprotein receptor 1 (Asgr1), 200 uL, ,10^7 TU/mL. Not available. ...
A C-type lectin that is a cell surface receptor for ASIALOGLYCOPROTEINS. It is found primarily in the LIVER where it mediates ... Asialoorosomucoid Receptors Expand. A C-type lectin that is a cell surface receptor for ASIALOGLYCOPROTEINS. It is found ... Asialoglycoprotein Receptor. Known as: Receptor, Asialoglycoprotein, ASGP-R, ... Intracellular site of asialoglycoprotein receptor-ligand uncoupling: Double-label immunoelectron microscopy during receptor- ...
Receptors, Cell Surface / metabolism* Substances * Antigen-Antibody Complex * Asialoglycoprotein Receptor * Asialoglycoproteins ... The role of asialoglycoprotein receptors Lab Invest. 1993 Dec;69(6):714-23. ... MTT values of AAGP and IgA1-IgG aggregate were strictly related (p = 0.008), suggesting that asialoglycoprotein receptors are ... the relative significance of the asialoglycoprotein receptors in IgAIC clearance is still uncertain. ...
Receptor-mediated endocytosis of asialoglycoproteins by rat hepatocytes: receptor-positive and receptor-negative endosomes, ... the asialoglycoprotein receptor to secretory component during transport across the rat hepatocyte, journal = j-J-CELL-BIOL, ... pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells, journal = j-J-CELL-BIOL, volume = ... Receptor-mediated endocytosis of asialoglycoproteins by rat liver hepatocytes: biochemical characterization of the endosomal ...
Trafficking of asialoglycoproteins and the asialoglycoprotein receptor. Targeted Diagn Ther. 1991;4:3-39. PMID:1797161 ... Different fates for asialoglycoproteins and the asialoglycoprotein receptor in HepG2 cells. J Biol Chem. 1986;261(32):15225-32. ... Cell biology of the asialoglycoprotein receptor system: a model of receptor-mediated endocytosis. Int Rev Cytol. 1985;97:47-95. ... The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors. Cell. 1983;32 ...
Receptor‐mediated endocytosis of asialoglycoproteins by rat liver hepatocytes: biochemical characterization of the endosomal ... Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human ... Phenylarsine oxide‐induced increase in alveolar macrophage surface receptors: evidence for fusion of internal receptor pools ... Transferrin receptors recycle to cis and middle as well as trans Golgi cisternae in Ig‐secretory myeloma cells. J. Cell Biol. ...
Asialoglycoprotein clearance in the chicken: evidence for the lack of a hepatic asialoglycoprotein receptor Academic Article ... Two populations of prelysosomal structures transporting asialoglycoproteins in rat liver. Academic Article ... Receptor-interacting protein 140 interacts with and inhibits transactivation by, peroxisome proliferator-activated receptor α ... correlation with endogenous benzodiazepine receptor ligands and increased affinity of platelet receptors. Academic Article ...
The aortic AGT, ACE, angiotensin II type 1 (AT1) receptor and angiotensin II type 2 (AT2) receptor mRNA also did not ... The ODNs against rat AGT were coupled to asialoglycoprotein (ASOR) carrier molecules, which serve as an important method for ... Asialoglycoproteins Medicine & Life Sciences 完全なフィンガープリントを表示 ... The aortic AGT, ACE, angiotensin II type 1 (AT1) receptor and angiotensin II type 2 (AT2) receptor mRNA also did not ...
  • The selective binding (calcium and pH depended) and uptake of terminal galactosyl bearing proteins requires the formation of hetero-oligomers between these major and minor forms The total ASGP receptor population consisted of two functionally distinct receptor populations, designated State 1 and State 2, which were involved in the endocytosis and intracellular processing of ligands by different pathways. (acris-antibodies.com)
  • The isolated receptor is a hetero-oligomeric complex constituted of two subunits with molecular masses of 40- and 47-kDa. (mun.ca)