ASFV DNA polymerse X is extremely error-prone under diverse assay conditions and within multiple DNA sequence contexts. (1/6)
We previously demonstrated that the DNA repair system encoded by the African swine fever virus (ASFV) is both extremely error-prone during the single-nucleotide gap-filling step (catalyzed by ASFV DNA polymerase X) and extremely error-tolerant during the nick-sealing step (catalyzed by ASFV DNA ligase). On the basis of these findings we have suggested that at least some of the diversity known to exist among ASFV isolates may be a consequence of mutagenic DNA repair, wherein damaged nucleotides are replaced with undamaged but incorrect nucleotides by Pol X and the resultant mismatched nicks are sealed by ASFV DNA ligase. Recently, this hypothesis appeared to be discredited by Salas and co-workers [(2003) J. Mol. Biol. 326, 1403-1412], who reported the fidelity of Pol X to be, on average, 2 orders of magnitude higher than what we previously published. In an effort to address this discrepancy and provide a definitive conclusion about the fidelity of Pol X, herein we examine the fidelity of Pol X-catalyzed single-nucleotide gap-filling in both the steady state and the pre-steady state under a diverse array of assay conditions (varying pH and ionic strength) and within different DNA sequence contexts. These studies corroborate our previously published data (demonstrating the low fidelity of Pol X to be independent of assay condition/sequence context), do not reproduce the data of Salas et al., and therefore confirm Pol X to be one of the most error-prone polymerases known. These results are discussed in light of ASFV biology and the mutagenic DNA repair hypothesis described above. (+info)Recombinant antigen targets for serodiagnosis of African swine fever. (2/6)
(+info)Eukaryotic large nucleo-cytoplasmic DNA viruses: clusters of orthologous genes and reconstruction of viral genome evolution. (3/6)
(+info)Evolution of DNA ligases of nucleo-cytoplasmic large DNA viruses of eukaryotes: a case of hidden complexity. (4/6)
(+info)Development and validation of a multiplex, real-time RT PCR assay for the simultaneous detection of classical and African swine fever viruses. (5/6)
(+info)Prevalence of African swine fever virus in apparently healthy domestic pigs in Uganda. (6/6)
(+info)
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Difference between revisions of User:Modesto Redrejo Rodríguez - OpenWetWare
Nucleocytoviricota
... possibly under Asfarviridae (Asfuvirales) Faustovirus - now under Asfarviridae (Asfuvirales) Kaumoebavirus - clusters under ... Asfarviridae is either a sister group to Poxviridae (building together Pokkesviricetes) or a member of the P2 clade. The ICTV ... A member of the family Asfarviridae is known as an asfarvirus. This virus is the cause of African swine fever. Some of the ... likely under Asfarviridae (Asfuvirales) Platanovirus - similar to Megavirus or Tupanvirus (Imitervirales) Sissivirus and ...
African swine fever virus
... (ASFV) is a large, double-stranded DNA virus in the Asfarviridae family. It is the causative agent of ... It is the only species in the genus Asfivirus, family Asfarviridae, and order Asfuvirales. Each of these three taxa is at least ... Asfarviridae, Animal viral diseases, Biological anti-agriculture weapons). ...
Dinodnavirus
DNA studies have shown that it seems more likely to be related to the family Asfarviridae. Tarutani K, Nagasaki K, Itakura S, ...
Royal Farm virus
Tick-borne viruses are found in six different virus families (Asfarviridae, Reoviridae, Rhabdoviridae, Orthomyxoviridae, ...
Viral Bioinformatics Resource Center
The VBRC covers the following viruses: Poxviridae Asfarviridae The VBRC database stores viral bioinformatic data on three ...
Faustovirus
Asfarviridae, All stub articles, Virus stubs). ...
Veterinary virology
... large double-stranded DNA virus which replicates in the cytoplasm of infected cells and is the only member of the Asfarviridae ...
Viral envelope
The following are some examples of enveloped viruses: DNA viruses Herpesviruses Poxviruses Hepadnaviruses Asfarviridae RNA ...
List of MeSH codes (B04)
... asfarviridae MeSH B04.909.204.102.035 - african swine fever virus MeSH B04.909.204.120 - circoviridae MeSH B04.909.204.120.150 ...
Arbovirus
With the exception of the African swine fever virus, which belongs to the Asfarviridae family of viruses, all major clinically ...
Poxviridae
Asfarviridae), Chlorella viruses (Phycodnaviridae) and poxviruses (Poxviridae). The mutation rate in poxvirus genomes has been ...
Cafeteria roenbergensis virus
... analysis suggested that the helicase of the virus was phylogenetically related to those found in the family Asfarviridae, and ...
List of virus families and subfamilies
Amalgaviridae Amnoonviridae Ampullaviridae Anelloviridae Arenaviridae Arteriviridae Artoviridae Ascoviridae Asfarviridae ...
Infectious Dose of African Swine Fever Virus When Consumed Naturally in Liquid or Feed - Volume 25, Number 5-May 2019 -...
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Publication : USDA ARS
Viruses | Free Full-Text | Identification of a Continuously Stable and Commercially Available Cell Line for the Identification...
Keywords
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Asfivirus1
- The causative agent, African swine fever virus (ASFV), is a complex DNA virus of the genus Asfivirus within the Asfarviridae family. (cdc.gov)
VIRUSES1
- Based on the genome organisation and DNA replication mechanism a phylogenetic relationships may exist between the rudiviruses (Rudiviridae) and the large eukaryal DNA viruses: the African swine fever virus ( Asfarviridae ), Chlorella viruses (Phycodnaviridae) and poxviruses (Poxviridae). (hyperleap.com)
Family4
- The virus is a member of the Asfarviridae family and is the only known vectorborne DNA virus ( 7 ). (cdc.gov)
- African swine fever virus (ASFV) is the sole member of the family Asfarviridae, and the only known DNA arbovirus. (usda.gov)
- DNA virus of the family Asfarviridae and zoosanitary measures. (cdc.gov)
- African swine fever virus (ASFV) is a large, double-stranded DNA virus in the Asfarviridae family. (foodtestkit.com)
Genus4
- African swine fever virus is a large, enveloped, double-stranded DNA virus that is the sole member of the genus Asfivirus within the family Asfarviridae. (merckvetmanual.com)
- ASF disebabkan oleh virus DNA untai ganda dari genus Asfivirus dan famili Asfarviridae. (pertanian.go.id)
- Interestingly, a double stranded DNA virus causes ASF, of the genus Asfivirus , Family Asfarviridae. (myvetzone.com)
- It zdvv caused by a large Zd zdv of the Asfarviridae family, which also infects ticks zdv the genus Ornithodoros. (nimotop.top)
ASFV2
- The causative agent of ASF, ASF virus (ASFV), is a double-stranded DNA virus, the sole member in the family Asfarviridae. (populationhealthsciences.org)
- With over 100 reports of the highly contagious outbreak of African Swine Fever Virus (ASFV-Asfarviridae) across Europe and Asia recorded during the start of autumn. (techtrol.co.uk)
Viruses2
- This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the taxonomy of the Asfarviridae, which is available at www.ictv.global/report/asfarviridae. (nih.gov)
- Together with other viruses that have a replicative stage in the cytoplasm, the Asfarviridae have been classified in the Phylum "Nucleocytoviricota" (ICTV Master Species List 2019.v1). (merckvetmanual.com)
Single species1
- The family Asfarviridae includes the single species African swine fever virus, isolates of which have linear dsDNA genomes of 170-194 kbp. (nih.gov)
Contagious2
- African Swine Fever (ASF) is a highly contagious haemorrhagic viral disease of domestic pigs, caused by a large DNA virus of the Asfarviridae family The disease which affects pigs of any age can result in a high mortality rate and is responsible for the recent production and economic losses in so. (onbizy.com)
- African Swine Fever (ASF) is a highly contagious, generalized disease of pigs caused by an Iridovirus of family Asfarviridae that exhibits varying virulence between strains and is very hardy to physical and chemical inactivation. (outbreaknewstoday.com)