Ascorbic acid deficiency. Medical search

A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)

An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.

A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.

Rats bearing mutant genes which are phenotypically expressed in the animals.

Long chain organic acid molecules that must be obtained from the diet. Examples are LINOLEIC ACIDS and LINOLENIC ACIDS.

Plasma glycoproteins that form a stable complex with hemoglobin to aid the recycling of heme iron. They are encoded in man by a gene on the short arm of chromosome 16.

A nutritional condition produced by a deficiency of FOLIC ACID in the diet. Many plant and animal tissues contain folic acid, abundant in green leafy vegetables, yeast, liver, and mushrooms but destroyed by long-term cooking. Alcohol interferes with its intermediate metabolism and absorption. Folic acid deficiency may develop in long-term anticonvulsant therapy or with use of oral contraceptives. This deficiency causes anemia, macrocytic anemia, and megaloblastic anemia. It is indistinguishable from vitamin B 12 deficiency in peripheral blood and bone marrow findings, but the neurologic lesions seen in B 12 deficiency do not occur. (Merck Manual, 16th ed)

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.

A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)

The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

Anemia characterized by larger than normal erythrocytes, increased mean corpuscular volume (MCV) and increased mean corpuscular hemoglobin (MCH).

Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.

The presence of methemoglobin in the blood, resulting in cyanosis. A small amount of methemoglobin is present in the blood normally, but injury or toxic agents convert a larger proportion of hemoglobin into methemoglobin, which does not function reversibly as an oxygen carrier. Methemoglobinemia may be due to a defect in the enzyme NADH methemoglobin reductase (an autosomal recessive trait) or to an abnormality in hemoglobin M (an autosomal dominant trait). (Dorland, 27th ed)

A species of CORONAVIRUS causing atypical respiratory disease (SEVERE ACUTE RESPIRATORY SYNDROME) in humans. The organism is believed to have first emerged in Guangdong Province, China, in 2002. The natural host is the Chinese horseshoe bat, RHINOLOPHUS sinicus.

A disease-producing enzyme deficiency subject to many variants, some of which cause a deficiency of GLUCOSE-6-PHOSPHATE DEHYDROGENASE activity in erythrocytes, leading to hemolytic anemia.

A viral disorder characterized by high FEVER, dry COUGH, shortness of breath (DYSPNEA) or breathing difficulties, and atypical PNEUMONIA. A virus in the genus CORONAVIRUS is the suspected agent.

A class I viral fusion protein that forms the characteristic spikes, or peplomers, found on the viral surface that mediate virus attachment, fusion, and entry into the host cell. During virus maturation, it is cleaved into two subunits: S1, which binds to receptors in the host cell, and S2, which mediates membrane fusion.

The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.

A genus of the family CORONAVIRIDAE which causes respiratory or gastrointestinal disease in a variety of vertebrates.

Dietary antioxidants and magnesium in type 1 brittle asthma: a case control study. (1/213)

BACKGROUND: Type 1 brittle asthma is a rare form of asthma. Atopy, psychosocial factors and diet may contribute to this condition. As increased dietary magnesium has a beneficial effect on lung function and selenium, vitamins A, C and E have antioxidant properties, a study was undertaken to test the hypothesis that patients with brittle asthma have diets deficient in these nutrients compared with subjects with non-brittle asthma and healthy adults. METHODS: A case control study of the dietary intakes of 20 subjects with brittle asthma, 20 with non-brittle asthma, and 20 healthy adults was performed using five day weighed dietary records. Intake of magnesium was the primary outcome measure with selenium and vitamins A, C and E as secondary outcomes. Serum levels were measured at the same time as the dietary assessment. RESULTS: Sixty subjects (27 men) of mean age 49.5 years were recruited and completed the study. Subjects with brittle asthma had statistically lower median dietary intakes of vitamins A and E than the other groups (vitamin A: brittle asthma 522.5 micrograms/day, non-brittle asthma 869.5 micrograms/day, healthy adults 806.5 micrograms/day; vitamin E: brittle asthma 4.3 mg/day, non-brittle asthma 4.6 mg/day, healthy adults 4.5 mg/day). Median dietary intakes for the other nutrients were not significantly different between groups. Serum levels were within normal ranges for each nutrient in all subjects. Intakes less than the reference nutrient intake (RNI) for magnesium and vitamins A and C, and less than the safe intake (SI) for vitamin E were more likely in patients with brittle asthma than in those with non-brittle asthma. CONCLUSION: Nutrient deficiency and reduced antioxidant activity may contribute to disease activity in type 1 brittle asthma, although a prospective study of replacement therapy will be needed to confirm this hypothesis. (+info)

Parenteral vitamin requirements during intravenous feeding. (2/213)

Serum vitamin levels of 40 patients undergoing parenteral nutrition over a 5-to 42-day period were studied while the subjects received daily water-soluble and once weekly fat soluble vitamin formulations intravenously. Initial serum deficiencies of vitamins A, C, and folate were noted in a large portion of the severely malnourished population. At the replacement levels used in this study a small number of patients developed subnormal levels of vitamins A and D. Improvement in levels for vitamin C and folate were noted for most patients. Vitamin B12 deficiencies were not noted in any patient. Currently available commercial vitamin preparations can be used with safety in the parenterally nourished population and recommended guidelines for weekly infusion of both water and fat soluble vitamins are presented. (+info)

Aortic wall damage in mice unable to synthesize ascorbic acid. (3/213)

By inactivating the gene for L-gulono-gamma-lactone oxidase, a key enzyme in ascorbic acid synthesis, we have generated mice that, like humans, depend on dietary vitamin C. Regular chow, containing about 110 mg/kg of vitamin C, is unable to support the growth of the mutant mice, which require L-ascorbic acid supplemented in their drinking water (330 mg/liter). Upon withdrawal of supplementation, plasma and tissue ascorbic acid levels decreased to 10-15% of normal within 2 weeks, and after 5 weeks the mutants became anemic, began to lose weight, and die. Plasma total antioxidative capacities were approximately 37% normal in homozygotes after feeding the unsupplemented diet for 3-5 weeks. As plasma ascorbic acid decreased, small, but significant, increases in total cholesterol and decreases in high density lipoprotein cholesterol were observed. The most striking effects of the marginal dietary vitamin C were alterations in the wall of aorta, evidenced by the disruption of elastic laminae, smooth muscle cell proliferation, and focal endothelial desquamation of the luminal surface. Thus, marginal vitamin C deficiency affects the vascular integrity of mice unable to synthesize ascorbic acid, with potentially profound effects on the pathogenesis of vascular diseases. Breeding the vitamin C-dependent mice with mice carrying defined genetic mutations will provide numerous opportunities for systematic studies of the role of antioxidants in health and disease. (+info)

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. (4/213)

BACKGROUND: Lack of reliable dietary data has hampered the ability to effectively distinguish between effects of smoking and diet on plasma antioxidant status. As confirmed by analyses of comprehensive food-frequency questionnaires, the total dietary intakes of fruit and vegetables and of dietary antioxidants were not significantly different between the study groups in the present study, thereby enabling isolation of the effect of smoking. OBJECTIVE: Our objective was to investigate the effect of smoking on plasma antioxidant status by measuring ascorbic acid, alpha-tocopherol, gamma-tocopherol, beta-carotene, and lycopene, and subsequently, to test the effect of a 3-mo dietary supplementation with a moderate-dose vitamin cocktail. DESIGN: In a double-blind, placebo-controlled design, the effect of a vitamin cocktail containing 272 mg vitamin C, 31 mg all-rac-alpha-tocopheryl acetate, and 400 microg folic acid on plasma antioxidants was determined in a population of smokers (n = 37) and nonsmokers (n = 38). The population was selected for a low intake of fruit and vegetables and recruited from the San Francisco Bay area. RESULTS: Only ascorbic acid was significantly depleted by smoking per se (P < 0.01). After the 3-mo supplementation period, ascorbic acid was efficiently repleted in smokers (P < 0.001). Plasma alpha-tocopherol and the ratio of alpha- to gamma-tocopherol increased significantly in both supplemented groups (P < 0.05). CONCLUSIONS: Our data suggest that previous reports of lower concentrations of plasma vitamin E and carotenoids in smokers than in nonsmokers may primarily have been caused by differences in dietary habits between study groups. Plasma ascorbic acid was depleted by smoking and repleted by moderate supplementation. (+info)

Plasma vitamin C and food choice in the third Glasgow MONICA population survey. (5/213)

STUDY OBJECTIVE: To determine the contribution of different foods to the estimated intakes of vitamin C among those differing in plasma vitamin C levels, and thereby inform dietary strategies for correcting possible deficiency. DESIGN: Cross sectional random population survey. SETTING: North Glasgow, Scotland, 1992. PARTICIPANTS: 632 men and 635 women, aged 25 to 74 years, not taking vitamin supplements, who participated in the third MONICA study (population survey monitoring trends and determinants of cardiovascular disease). MEASUREMENTS AND MAIN RESULTS: Dietary and sociodemographic information was collected using a food frequency and lifestyle questionnaire. Plasma vitamin C was measured in non-fasted venous blood samples and subjects categorised by cut points of 11.4 and 22.7 micromol/l as being of low, marginal or optimal vitamin C status. Food sources of dietary vitamin C were identified for subjects in these categories. Plasma vitamin C concentrations were compared among groups classified according to intake of key foods. More men (26%) than women (14%) were in the low category for vitamin C status; as were a higher percentage of smokers and of those in the older age groups. Intake of vitamin C from potatoes and chips (fried potatoes) was uniform across categories; while the determinants of optimal versus low status were the intakes of citrus fruit, non-citrus fruit and fruit juice. Optimal status was achieved by a combined frequency of fruit, vegetables and/or fruit juice of three times a day or more except in older male smokers where a frequency greater than this was required even to reach a marginal plasma vitamin C level. CONCLUSION: Fruit, vegetables and/or fruit juice three or more times a day increases plasma vitamin C concentrations above the threshold for risk of deficiency. (+info)

Vitamin C status and mortality in US adults. (6/213)

BACKGROUND: Low vitamin C status may increase the risk of mortality from cancer and cardiovascular disease. OBJECTIVE: The objective was to test whether an association existed between serum ascorbate concentrations and mortality and whether the association was modified by cigarette smoking status or sex. DESIGN: Serum ascorbate concentrations were measured in adults as part of the second National Health and Nutrition Examination Survey (1976-1980). Vital status was ascertained 12-16 y later. RESULTS: The relative risk (RR) of death, adjusted for potential confounders, was estimated by using Cox proportional hazards models. Men in the lowest (<28.4 micromol/L) compared with the highest (>/=73.8 micromol/L) serum ascorbate quartile had a 57% higher risk of dying from any cause (RR: 1.57; 95% CI: 1.21, 2.03) and a 62% higher risk of dying from cancer (RR: 1.62; 95% CI: 1.01, 2.59). In contrast, there was no increased risk among men in the middle 2 quartiles for these outcomes and no increased risk of cardiovascular disease mortality in any quartile. There was no association between serum ascorbate quartile and mortality among women. These findings were consistent when analyses were limited to nonsmokers or further to adults who never smoked, suggesting that the observed relations were not due to cigarette smoking. CONCLUSIONS: These data suggest that men with low serum ascorbate concentrations may have an increased risk of mortality, probably because of an increased risk of dying from cancer. In contrast, serum ascorbate concentrations were not related to mortality among women. (+info)

Oral contraceptives and ascorbic acid. (7/213)

Plasma, leukocyte, and platelet ascorbic acid levels are decreased in women ingesting oral contraceptive steroids. Studies have shown that it is the estrogenic component of the oral contraceptive agents that is associated with the decresased ascorbic acid concentrations. Urinary excretion of ascorbic acid does not appear to be increased by the steroids. Although serum levels of copper are increased by estrogens and oral contraceptives, ascorbic acid catabolism does not appear to be increased (unpublished). Our preliminary data on tissue uptake of ascorbic acid suggest that changes in tissue distribution are one possible answer for the observed effects of the steroids on blood levels of ascorbic acid. (+info)

Fractured neck of femur in black patients: a prospective study. (8/213)

We explored the role of iron overload, deficiency of vitamin C and alcohol abuse in the aetiology of cervical and intertrochanteric fractures of the neck of the femur as a result of minor trauma. We studied prospectively 72 patients (45 men, 27 women). Levels of serum iron markers, vitamin C and alcohol markers were measured. Consumption of alcohol was estimated using questionnaires. The findings were compared with those of an age- and gender-matched control group. The mean age of the men was 59.5 years and of the women 66.9 years, with a male predominance. In the men, iron overload, as shown by high levels of serum ferritin (p < 0.001) and deficiency of vitamin C (p < 0.03), as well as abuse of both Western and the traditional type of alcohol, appear to be important aetiological factors. In women, alcohol abuse was also common, but iron markers and levels of vitamin C did not differ significantly from the control group. (+info)

Ascorbic acid deficiency can occur due to several reasons, including:

1. Poor diet: A diet that is lacking in vitamin C-rich foods such as citrus fruits, leafy greens, and bell peppers can lead to a deficiency.
2. Inability to absorb vitamin C: Certain medical conditions such as celiac disease, Crohn's disease, and ulcerative colitis can impair the body's ability to absorb vitamin C from food.
3. Increased demand: Vitamin C is essential for wound healing, and during pregnancy and lactation, the body requires more vitamin C to support fetal growth and development.
4. Long-term use of antacids or proton pump inhibitors: These medications can reduce the absorption of vitamin C.

The symptoms of ascorbic acid deficiency can vary depending on the severity of the deficiency and may include:

1. Fatigue and weakness
2. Mood changes such as irritability, anxiety, or depression
3. Difficulty healing from wounds or infections
4. Swelling or bleeding in the gums
5. Joint pain and stiffness
6. Frequent infections such as the common cold or flu
7. Poor digestion and diarrhea

If left untreated, ascorbic acid deficiency can lead to more severe conditions such as scurvy, which can cause:

1. Bleeding gums and teeth
2. Joint pain and swelling
3. Weakened immune system
4. Poor wound healing
5. Fatigue and weakness

Treatment for ascorbic acid deficiency typically involves supplementing with vitamin C, either orally or intravenously, and addressing any underlying causes of the deficiency. In severe cases, hospitalization may be necessary to monitor and treat any complications.

Prevention is key, so it's important to maintain a balanced diet that includes foods rich in vitamin C, such as citrus fruits, leafy greens, and berries. Additionally, avoiding smoking and limiting alcohol consumption can also help prevent ascorbic acid deficiency.

In conclusion, ascorbic acid deficiency is a common nutrient deficiency that can have significant impacts on overall health and well-being. Recognizing the causes, symptoms, and treatment options is essential for proper management and prevention of this condition.

There are several ways to prevent and treat scurvy, including:

* Eating foods rich in vitamin C, such as citrus fruits, leafy greens, and bell peppers.
* Taking vitamin C supplements.
* Increasing the intake of other nutrients that help the body absorb vitamin C, such as calcium and potassium.
* Avoiding foods and drinks that are high in oxalic acid, which can interfere with the absorption of vitamin C.

The discovery of scurvy and its treatment have had a significant impact on the history of medicine and nutrition. It led to the discovery of other essential nutrients and the development of modern nutrition science.

1. Anemia: Folic acid plays a critical role in the production of red blood cells, so a deficiency can lead to anemia, which can cause fatigue, weakness, and shortness of breath.
2. Birth defects: Folic acid is crucial for fetal development during pregnancy, and a deficiency can increase the risk of birth defects such as spina bifida and cleft palate.
3. Heart disease: Folic acid helps to regulate homocysteine levels in the blood, which are associated with an increased risk of heart disease and stroke.
4. Neurological problems: Folic acid is important for the health of the nervous system, and a deficiency can lead to neurological problems such as cognitive impairment, mood disturbances, and seizures.
5. Poor wound healing: Folic acid is necessary for the production of collagen, which is important for wound healing. A deficiency can lead to slow or poor wound healing.
6. Increased risk of cancer: Some studies suggest that a folic acid deficiency may increase the risk of certain types of cancer, such as colon cancer.
7. Hair loss: Folic acid is important for hair growth, and a deficiency can lead to hair loss.
8. Skin problems: Folic acid is important for skin health, and a deficiency can lead to skin problems such as dry, flaky skin and mouth sores.
9. Mood changes: Folic acid plays a role in the production of neurotransmitters, which are chemicals that regulate mood. A deficiency can lead to mood changes such as depression and anxiety.
10. Fatigue: Folic acid is important for energy metabolism, and a deficiency can lead to fatigue and weakness.

Folic acid deficiency can be caused by a number of factors, including:

1. Poor diet: A diet that is low in folate-rich foods can lead to a deficiency.
2. Malabsorption: Certain medical conditions such as celiac disease and Crohn's disease can lead to malabsorption of folic acid.
3. Pregnancy and lactation: Women who are pregnant or breastfeeding have a higher need for folic acid, and may be at risk for deficiency if they do not consume enough.
4. Alcoholism: Heavy alcohol consumption can interfere with the absorption of folic acid.
5. Certain medications: Some medications, such as antacids and proton pump inhibitors, can interfere with the absorption of folic acid.

To diagnose a folic acid deficiency, a healthcare provider may perform a physical exam, take a medical history, and order blood tests to measure folic acid levels. Treatment for a folic acid deficiency typically involves dietary changes and supplements. Dietary changes may include consuming more folate-rich foods, such as leafy green vegetables, legumes, and whole grains. Supplements may include folic acid tablets or liquid supplements. In severe cases of deficiency, injections of folic acid may be necessary. It is important to seek medical attention if you suspect a folic acid deficiency, as untreated deficiencies can lead to serious health problems.

1. Scurvy: A disease caused by a lack of vitamin C in the diet, leading to bleeding gums, weakened immune system, and poor wound healing.
2. Rickets: A disease that affects children and is caused by a lack of calcium and vitamin D, leading to soft and weak bones.
3. Anemia: A condition where the body does not have enough red blood cells or hemoglobin, which can be caused by a lack of iron, folate, or vitamin B12.
4. Beriberi: A condition that affects the heart and nervous system and is caused by a lack of vitamin B1 (thiamine), leading to muscle weakness, fatigue, and heart failure.
5. Goiter: An enlarged thyroid gland that can be caused by a lack of iodine in the diet, leading to hypothyroidism and other complications.
6. Pellagra: A disease caused by a lack of niacin (vitamin B3) in the diet, leading to diarrhea, dermatitis, and dementia.
7. Kwashiorkor: A condition that occurs in children who are malnourished due to a lack of protein in their diet, leading to edema, skin lesions, and diarrhea.
8. Marasmus: A severe form of malnutrition that can be caused by a lack of calories, protein, or other essential nutrients, leading to weight loss, wasting, and weakened immune system.

Deficiency diseases can be prevented by consuming a well-balanced diet that includes a variety of whole foods, such as fruits, vegetables, whole grains, lean proteins, and healthy fats. In some cases, deficiency diseases may also be treated with supplements or other medical interventions.

It is important to note that deficiency diseases can have far-reaching consequences for individuals, families, and communities. Malnutrition can lead to reduced productivity, increased healthcare costs, and a lower quality of life. Therefore, it is essential to prioritize nutrition and take steps to prevent deficiency diseases.

Body weight is an important health indicator, as it can affect an individual's risk for certain medical conditions, such as obesity, diabetes, and cardiovascular disease. Maintaining a healthy body weight is essential for overall health and well-being, and there are many ways to do so, including a balanced diet, regular exercise, and other lifestyle changes.

There are several ways to measure body weight, including:

1. Scale: This is the most common method of measuring body weight, and it involves standing on a scale that displays the individual's weight in kg or lb.
2. Body fat calipers: These are used to measure body fat percentage by pinching the skin at specific points on the body.
3. Skinfold measurements: This method involves measuring the thickness of the skin folds at specific points on the body to estimate body fat percentage.
4. Bioelectrical impedance analysis (BIA): This is a non-invasive method that uses electrical impulses to measure body fat percentage.
5. Dual-energy X-ray absorptiometry (DXA): This is a more accurate method of measuring body composition, including bone density and body fat percentage.

It's important to note that body weight can fluctuate throughout the day due to factors such as water retention, so it's best to measure body weight at the same time each day for the most accurate results. Additionally, it's important to use a reliable scale or measuring tool to ensure accurate measurements.

Symptoms of macrocytic anemia may include fatigue, weakness, pale skin, and shortness of breath. Diagnosis is typically made through a complete blood count (CBC) test that shows an elevated mean corpuscular volume (MCV) and reticulocyte count. Treatment depends on the underlying cause, but may include vitamin supplements, changes in medication, or addressing any underlying medical conditions.

In summary, macrocytic anemia is a type of anemia characterized by large red blood cells that are prone to breakdown and can be caused by various factors. It can cause symptoms such as fatigue, weakness, and shortness of breath, and diagnosis is made through a CBC test. Treatment depends on the underlying cause.

There are several possible causes of methemoglobinemia, including:

1. Exposure to certain medications or chemicals, such as nitrates or aniline dyes.
2. Genetic disorders that affect the production or function of hemoglobin.
3. Infections, such as bacterial infections of the blood or respiratory tract.
4. Poor nutrition or malnutrition.
5. Certain chronic medical conditions, such as sickle cell anemia or thalassemia.

Methemoglobinemia can be diagnosed through a variety of tests, including:

1. Complete blood count (CBC) to measure the levels of methemoglobin in the blood.
2. Blood gas analysis to measure the partial pressure of oxygen and carbon dioxide in the blood.
3. Co-oximetry to measure the levels of methemoglobin and other forms of hemoglobin.
4. Urine tests to check for the presence of abnormal hemoglobin.
5. Genetic testing to identify inherited disorders that may be causing the condition.

Treatment of methemoglobinemia depends on the underlying cause and may include:

1. Administration of oxygen therapy to increase the amount of oxygen in the blood.
2. Use of medications to reduce the levels of methemoglobin and increase the levels of normal hemoglobin.
3. Transfusions of red blood cells to replace abnormal hemoglobin with normal hemoglobin.
4. Management of underlying medical conditions, such as infections or genetic disorders.
5. Dietary changes to address any nutritional deficiencies that may be contributing to the condition.

In severe cases of methemoglobinemia, hospitalization may be necessary to provide oxygen therapy and other treatments. In some cases, patients with methemoglobinemia may require long-term management and follow-up care to prevent complications and manage the underlying cause of the condition.

The condition is inherited in an X-linked recessive pattern, meaning that the gene for G6PD deficiency is located on the X chromosome and affects males more frequently than females. Females may also be affected but typically have milder symptoms or may be carriers of the condition without experiencing any symptoms themselves.

G6PD deficiency can be caused by mutations in the G6PD gene, which can lead to a reduction in the amount of functional enzyme produced. The severity of the condition depends on the specific nature of the mutation and the degree to which it reduces the activity of the enzyme.

Symptoms of G6PD deficiency may include jaundice (yellowing of the skin and eyes), fatigue, weakness, and shortness of breath. In severe cases, the condition can lead to hemolytic anemia, which is characterized by the premature destruction of red blood cells. This can be triggered by certain drugs, infections, or foods that contain high levels of oxalic acid or other oxidizing agents.

Diagnosis of G6PD deficiency typically involves a combination of clinical evaluation, laboratory tests, and genetic analysis. Treatment is focused on managing symptoms and preventing complications through dietary modifications, medications, and avoidance of triggers such as certain drugs or infections.

Overall, G6PD deficiency is a relatively common genetic disorder that can have significant health implications if left untreated. Understanding the causes, symptoms, and treatment options for this condition is important for ensuring appropriate care and management for individuals affected by it.

The symptoms of SARS typically begin within 2-10 days after exposure and can include:

* Fever (>38°C)
* Chills
* Headache
* Body aches
* Fatigue
* Dry cough
* Shortness of breath or difficulty breathing
* Pneumonia

In severe cases, SARS can progress to respiratory failure, which can lead to death. The virus is highly contagious and can be spread through close contact with an infected person, as well as through contact with contaminated surfaces and objects.

SARS was first identified in 2003 in China, and it quickly spread to other countries around the world, causing a global outbreak. The World Health Organization (WHO) declared SARS a Public Health Emergency of International Concern (PHEIC) in March 2003, and it was eventually contained through a combination of measures such as isolation of infected individuals, contact tracing, and the use of personal protective equipment (PPE).

There is no specific treatment for SARS, but supportive care such as oxygen therapy and mechanical ventilation may be provided to help manage symptoms. Antiviral medications have been developed to treat SARS, but their effectiveness is still being studied. Prevention of SARS primarily relies on good hygiene practices, such as frequent handwashing, avoidance of close contact with people who are sick, and wearing PPE when caring for infected individuals.

Overall, Severe Acute Respiratory Syndrome (SARS) is a serious and potentially life-threatening respiratory illness that can be spread through close contact with an infected person. While it has been largely contained through public health measures, it remains important to continue practicing good hygiene and be aware of the risks of SARS in order to prevent its spread.

There are two main types of hemolysis:

1. Intravascular hemolysis: This type occurs within the blood vessels and is caused by factors such as mechanical injury, oxidative stress, and certain infections.
2. Extravascular hemolysis: This type occurs outside the blood vessels and is caused by factors such as bone marrow disorders, splenic rupture, and certain medications.

Hemolytic anemia is a condition that occurs when there is excessive hemolysis of RBCs, leading to a decrease in the number of healthy red blood cells in the body. This can cause symptoms such as fatigue, weakness, pale skin, and shortness of breath.

Some common causes of hemolysis include:

1. Genetic disorders such as sickle cell anemia and thalassemia.
2. Autoimmune disorders such as autoimmune hemolytic anemia (AIHA).
3. Infections such as malaria, babesiosis, and toxoplasmosis.
4. Medications such as antibiotics, nonsteroidal anti-inflammatory drugs (NSAIDs), and blood thinners.
5. Bone marrow disorders such as aplastic anemia and myelofibrosis.
6. Splenic rupture or surgical removal of the spleen.
7. Mechanical injury to the blood vessels.

Diagnosis of hemolysis is based on a combination of physical examination, medical history, and laboratory tests such as complete blood count (CBC), blood smear examination, and direct Coombs test. Treatment depends on the underlying cause and may include supportive care, blood transfusions, and medications to suppress the immune system or prevent infection.

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"Acute haemolysis induced by high dose ascorbic acid in glucose-6-phosphate dehydrogenase deficiency". British Medical Journal. ... Food portal Vitamin C Intravenous ascorbic acid Megavitamin therapy Orthomolecular medicine Uric acid Institute of Medicine ( ... The G6PD deficiency test is a common laboratory test. Because oxalic acid is produced during metabolism of vitamin C, ... "Vitamin C (Ascorbic Acid)". University of Maryland Medical Center. April 2002. Archived from the original on 2005-12-31. ...

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... scurvy is a disease resulting from a severe deficiency of vitamin C (ascorbic acid). Vitamin C is essential for the synthesis ...

https://en.wikipedia.org/wiki/Periodontal_fiber

... as well as ascorbic acid deficiency. Koehler, Franz A., Special Rations for the Armed Forces: Army Operational Rations - A ... Significantly, diagnosed cases of malnourishment and vitamin deficiency, which had been reported among other light infantry ... malnourishment and vitamin deficiency) had become apparent, the Quartermaster Corps attempted to shift responsibility for ...

https://en.wikipedia.org/wiki/Mountain_ration

The hydroxylation reaction is catalyzed by an enzyme that requires ascorbic acid (vitamin C), deficiencies in which lead to ... Amino acids are polymerised via peptide bonds to form a long backbone, with the different amino acid side chains protruding ... Protein sequencing Nucleic acid primary structure Translation Pseudo amino acid composition SANGER F (1952). "The arrangement ... The compression of amino acid sequences is a comparatively challenging task. The existing specialized amino acid sequence ...

https://en.wikipedia.org/wiki/Protein_primary_structure

... a key enzyme for ascorbic acid biosynthesis". Am. J. Clin. Nutr. 54 (6 Suppl): 1203S-1208S. doi:10.1093/ajcn/54.6.1203s. PMID ... Retrieved 2013-11-07.> Nishikimi M, Yagi K (December 1991). "Molecular basis for the deficiency in humans of gulonolactone ... the missing enzyme in L-ascorbic acid biosynthesis". Biochim. Biophys. Acta. 1472 (1-2): 408-11. doi:10.1016/S0304-4165(99) ...

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... ascorbic acid in hypervitaminosis A in guinea pigs, polycythemia in the rat in pyridoxine deficiency, skin permeability in ... and leukemia and Sinclair believed essential fatty acid (EFA) deficiency to be important in all three. EFA deficiency causes ... deficiency of essential fatty acids, vitamin deficiencies in alcoholism, vitamins and the nervous system, and nutritional ... "Deficiency of essential fatty acids and atherosclerosis, etcetera". The causes of death that had increased most in previous ...

https://en.wikipedia.org/wiki/Hugh_Macdonald_Sinclair

... ascorbic acid, vitamin D, magnesium, zinc, copper and manganese to name only a few There is a significant body of evidence ... this reason that bone growth is stunted during general malnutrition and specific bone abnormalities develop with deficiencies ...

https://en.wikipedia.org/wiki/Canadian_health_claims_for_food

... intragastric pH and ascorbic acid concentration in patients with Helicobacter pylori gastritis and associated iron deficiency ... Supplementation of folic acid in deficient patients can improve the histopathological findings of chronic atrophic gastritis ... The most common are vitamin B12 deficiency possibly leading to pernicious anemia; and malabsorption of iron, leading to iron ... Although, autoimmune atrophic gastritis impairs iron and vitamin B12 absorption, iron deficiency will be found at a younger age ...

https://en.wikipedia.org/wiki/Atrophic_gastritis

This salvage process delays onset of deficiency. Ascorbic acid also converts (reversibly) to dehydroascorbate (DHA) and from ... to produce ascorbic acid. l-Ascorbic acid has a negative feedback on l-galactose dehydrogenase in spinach. Ascorbic acid efflux ... "ascorbic acid" refer in the nutritional literature to l-ascorbate and l-ascorbic acid respectively. Ascorbic acid is a weak ... Haworth and Szent-Györgyi proposed that L-hexuronic acid be named a-scorbic acid, and chemically l-ascorbic acid, in honor of ...

https://en.wikipedia.org/wiki/Vitamin_C

... "injury or deficiency in dietary tryptophan and ascorbic acid can evoke similar signs", so conclusive diagnosis may require ...

https://en.wikipedia.org/wiki/Myxobolus_cerebralis

... is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, feeling ... Because of this, hexuronic acid was subsequently renamed ascorbic acid. Rates of scurvy in most of the world are low. Those ... Ascorbic acid is also not synthesized by at least two species of caviidae, the capybara and the guinea pig. There are known ... Ascorbic acid is needed for a variety of biosynthetic pathways, by accelerating hydroxylation and amidation reactions. In the ...

https://en.wikipedia.org/wiki/Scurvy

Foods rich in ascorbic acid (vitamin C) can also be beneficial, since ascorbic acid enhances iron absorption. Oral iron ... Iron deficiency affects up to 52% of pregnant women worldwide. The prevalence of iron deficiency as a cause of anemia varies ... Iron deficiency in pregnancy appears to cause long-term and irreversible cognitive problems in the baby. Iron deficiency ... "Micronutrient deficiencies". WHO. Archived from the original on 13 July 2017. Retrieved 17 July 2017. "How Can Iron-Deficiency ...

https://en.wikipedia.org/wiki/Iron-deficiency_anemia

Deficiency of vitamin C causes scurvy, formerly a major disease of sailors in long sea voyages. It is used as a food additive ... a diastereomer of ascorbic acid. Mineral ascorbates: salts of ascorbic acid Acids in wine Safety (MSDS) data for ascorbic acid ... Another major use of l-ascorbic acid is as dietary supplement. Ascorbic acid is easily oxidized and so is used as a reductant ... Iodine is reduced by ascorbic acid, and, when all the ascorbic acid has reacted, the iodine is then in excess, forming a blue- ...

https://en.wikipedia.org/wiki/Chemistry_of_ascorbic_acid

... a song by Can Chemistry of ascorbic acid Vitamin C and the common cold Vitamin C deficiency or scurvy Vitamin C megadosage, ... Vitamin C is an essential nutrient, the compound L-ascorbic acid. Vitamin C may also refer to: Vitamin C (singer), an American ...

https://en.wikipedia.org/wiki/Vitamin_C_(disambiguation)

... ascorbic acid) is also a required cofactor for the Dopamine beta hydroxylase enzyme. Recent research has shown that vitamin C ... Due to the deficiency of norepinephrine and epinephrine those affected by dopamine β-hydroxylase deficiency may present with ... Dopamine beta-hydroxylase deficiency is a very rare form of dysautonomia. It belongs to the class of rare diseases, with "a ... Therefore, DβH deficiency patients may have an inability to stand for a prolonged period of time. This phenomenon is especially ...

https://en.wikipedia.org/wiki/Dopamine_beta_hydroxylase_deficiency

Ascorbic acid, Scorbic meaning Scurvy).[citation needed] There is a ward named after him at St Mary's Hospital, Paddington, ... In 1932, the true cause of the disease was determined to be the deficiency from the diet of a particular nutrient, now called ...

https://en.wikipedia.org/wiki/Almroth_Wright

Hill CH (1979). "Studies on the ameliorating effect of ascorbic acid on mineral toxicities in the chick". J. Nutr. 109 (1): 84- ... Some of the most common deficiency observed with chronic mercury intake is a selenium deficiency. Such deficiency might impact ... Similar to thiamine, iron aggravates mercury exposure effect while ascorbic acid will help reduce the mercury toxicity effect. ... Other deficiencies that are observed with a persisting mercury intake are vitamin E, vitamin B12 and vitamin C. Long term ...

https://en.wikipedia.org/wiki/Mercury_regulation_in_the_United_States

The L-xylo-hex-3-gulonolactone then converts to hexuronic acid (ascorbic acid) spontaneously, without enzymatic action. The non ... L-Gulonolactone oxidase deficiency has been called "hypoascorbemia" and is described by OMIM (Online Mendelian Inheritance in ... However, the tissues of animal models with a GULO gene generally have high levels of ascorbic acid and so are often only ... There exists a wide discrepancy between the amounts of ascorbic acid other primates consume and what are recommended as " ...

https://en.wikipedia.org/wiki/L-gulonolactone_oxidase

... deficiency, found only in certain lines of mammals. GULO is required for converting glucose to ascorbic acid (vitamin C), which ... as an ascorbic-acid surrogate to repair arterial walls. The half-life of Lp(a) in circulation is approximately three to four ... each of the variable kringle IV consists of 114 amino acids). These variable apo(a) sizes are known as "apo(a) isoforms". There ...

https://en.wikipedia.org/wiki/Lipoprotein(a)

Ionophore Ghaskadbi S, Vaidya VG (March 1989). "In vivo antimutagenic effect of ascorbic acid against mutagenicity of the ... Diodoquin enhances zinc absorption in the zinc deficiency disorder Acrodermatitis enteropathica, probably because Diodoquin act ...

https://en.wikipedia.org/wiki/Diiodohydroxyquinoline

... and use ascorbic acid (vitamin C) to return the iron to its reduced state. Deprivation of ascorbate leads to deficiencies in ... It can take place on several amino acids, like lysine, asparagine, aspartate and histidine, but the most frequently ... of the protein in our bodies and contains a hydroxyproline at almost every 3rd residue in its amino acid sequence. Collagen ... hydroxylated amino acid residue in human proteins is proline. This is due to the fact that collagen makes up about 25-35% ...

https://en.wikipedia.org/wiki/Hydroxylation

"Effect of Ascorbic Acid on Copper and Cholesterol in adult cynomolgus monkeys fed a diet marginal in copper". The American ... "Hematopoietic Studies in Vitamin A Deficiencies". The American Journal of Clinical Nutrition. 31(5) 1978.[15] Milne, D.B. et al ... 32(11) 1979.[18] Hagler, L. "Influence of dietary iron deficiency on hemoglobin, myoglobin, their respective reductases, and ...

https://en.wikipedia.org/wiki/History_of_military_nutrition_in_the_United_States

Scurvy can result from a lack of vitamin C, also known as ascorbic acid. One author indicated that the nutritional value of ... The nutrient-deficiency disease pellagra is associated with a diet consisting primarily of maize, while the disease beriberi is ...

https://en.wikipedia.org/wiki/Staple_food

Terrestrial plants slowly optimized the production of new endogenous antioxidants such as ascorbic acid, polyphenols, ... August 2000). "Environmental Iodine Deficiency: A Challenge to the Evolution of Terrestrial Life?". Thyroid. 10 (8): 727-729. ... Nucleic acids such as RNA might then have formed more easily within the liposomes than outside. RNA is complex and there are ... Fatty acids in acidic or slightly alkaline geothermal springs assemble into vesicles after wet-dry cycles as there is a lower ...

https://en.wikipedia.org/wiki/History_of_life

Deficiency in any required amino acid or cofactor can impair the synthesis of dopamine, norepinephrine, and epinephrine. ... Dopamine is converted into norepinephrine by the enzyme dopamine β-hydroxylase, with O2 and L-ascorbic acid as cofactors. ... can be synthesized indirectly from the essential amino acid phenylalanine or directly from the non-essential amino acid ... These amino acids are found in nearly every protein and so are readily available in food, with tyrosine being the most common. ...

https://en.wikipedia.org/wiki/Dopamine

The blood plasma concentration of vitamin C or ascorbic acid as a function of dose attains a plateau with a half-life of about ... The plateau principle is important in determining how much time is needed to produce a deficiency when intake is insufficient. ... This principle has been demonstrated for the response of liver enzymes that degrade amino acids to cortisone, which is a ...

https://en.wikipedia.org/wiki/Plateau_principle

Another way to treat LID is with an iron rich diet and in addition ascorbic acid or Vitamin C, contained in many types of ... "Iron Deficiency Anemia". Merck Manuals Professional Edition. Retrieved 2016-06-22. "Iron deficiency anemia - Mayo Clinic". www. ... "The fortification of common salt with ascorbic acid and iron". British Journal of Haematology. 28 (4): 483-95. doi:10.1111/j. ... "Iron absorption from rice meals cooked with fortified salt containing ferrous sulphate and ascorbic acid". The British Journal ...

https://en.wikipedia.org/wiki/Latent_iron_deficiency

Ascorbic acid is oxidized to dehydroascorbic acid during this process, although it can be recycled back to ascorbic acid. Folic ... Thus, a deficiency of BH4 can lead to systemic deficiencies of dopamine, norepinephrine, and epinephrine. In fact, one of the ... Research shows that ascorbic acid (also known as ascorbate or vitamin C) can reduce BH3 radical into BH4, preventing the BH3 ... Kuzkaya N, Weissmann N, Harrison DG, Dikalov S (June 2003). "Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid ...

https://en.wikipedia.org/wiki/Tetrahydrobiopterin

Studies on metabolism of vitamin A: 7. Lowered synthesis of ascorbic acid in vitamin A deficient rats: P. Malathi and J. ... Effect of vitamin A deficiency on the concentrations of sodium and potassium in the blood plasma of rats: H. S. Juneja, S. K. ... Absorption of retinoic acid (vitamin A acid) in rats: D. S. Deshmukh, P. Malathi, K. Subba Rao and J. Ganguly, Indian J. ... Rapid conversion of retinal (vitamin A aldehyde) to retinoic acid (vitamin A acid) in the living rat: D. S. Deshmukh, P. ...

https://en.wikipedia.org/wiki/Jagannath_Ganguly

The kinetics of depolymerization of hyaluronic acid by l-ascorbic acid, and the inhibition of this reaction by anions of the ... led to a joint publication comparing practices and deficiencies in the application of creativity techniques in the UK and in ...

https://en.wikipedia.org/wiki/Tudor_Rickards

20 mg ascorbic acid, 3660 μg β-Carotene, 75 mg phosphorus, and 0.59 mg riboflavin per 100 g fresh weight. The leaves also ... as it is good for people with iron deficiencies, and malaria patients. The leaves of African nightshade are eaten as a cooked ...

https://en.wikipedia.org/wiki/African_nightshade

... such as ascorbic acid) in blood, hematocrit, dirt on meter, humidity, and aging of test strips. Models vary in their ... A known deficiency of all current meters is that the clock is often not set to the correct time (i.e., due to time changes, ...

https://en.wikipedia.org/wiki/Glucose_meter

Decrease in ascorbic acid (one form of vitamin C) content is observed but the positive effect on total phenol content and ... resulting in iodine deficiency symptoms such as goitre and decreased growth in Senegalese sole (Solea senegalensis) larvae. ... However, ozone application on strawberries in pre-harvest period shows decrease in ascorbic acid content. Ozone facilitates the ... and carboxylic acids, depending on the second step of the workup. Ozone can also cleave alkynes to form an acid anhydride or ...

https://en.wikipedia.org/wiki/Ozone

Zhang P, Omaye ST (February 2001). "Antioxidant and prooxidant roles for beta-carotene, alpha-tocopherol and ascorbic acid in ... an experimental therapeutic approach for the Fmr1 deficiency". Neuropsychopharmacology. 34 (4): 1011-1026. doi:10.1038/npp. ... Polyunsaturated fatty acids, particularly arachidonic acid and linoleic acid, are primary targets for free radical and singlet ... 11E-octadecadienoic acid, 9-hydroxy-10E,12-E-octadecadienoic acid (9-EE-HODE), and 11-hydroxy-9Z,12-Z-octadecadienoic acid as ...

https://en.wikipedia.org/wiki/Oxidative_stress

Such commonly recommended treatments include large doses of ascorbic acid (vitamin C) or dietary restriction of amino acids ... The defect was narrowed down to homogentisic acid oxidase deficiency in a study published in 1958. The genetic basis was ... The homogentisic acid is converted to the related substance benzoquinone acetic acid which forms polymers that resemble the ... the body accumulates an intermediate substance called homogentisic acid in the blood and tissues. Homogentisic acid and its ...

https://en.wikipedia.org/wiki/Alkaptonuria

Parenteral ascorbic acid as a key for regulating microcirculation in critically ill. Crit Care Med. 2008 Aug;36(8):2466-8 ... Seeliger MW, Biesalski HK, Wissinger B, Gollnick H, Gielen S, Frank J, Beck S, Zrenner E. Phenotype in retinol deficiency due ... These subjects also have night blindness and retinal dystrophy but few other signs of vitamin A deficiency." Strauss O The ... Biesalski HK, Wellner U, Weiser H. Vitamin A deficiency increases noise susceptibility in guinea pigs. J Nutr. 1990 Jul;120(7): ...

https://en.wikipedia.org/wiki/Hans_Konrad_Biesalski

Vitamin B12 deficiency has been linked to two diabetic complications; atherosclerosis and diabetic neuropathy. Folic acid: Low ... Antioxidants: Three vitamins, ascorbic acid; α-tocopherol; and β-carotene, are well recognized for their antioxidant activities ... Mullan B. A.; Young I. S.; Fee H.; McCance D. R. (2002). "Ascorbic acid reduces blood pressure and arterial stiffness in type 2 ... Additionally, deficiency of thiamine was observed to be associated with dysfunction of β-cells and impaired glucose tolerance. ...

https://en.wikipedia.org/wiki/Complications_of_diabetes

Lee YR, Vo K, Varughese JT (March 2022). "Benefits of combination therapy of hydrocortisone, ascorbic acid and thiamine in ... Vasopressin can be used in septic shock because studies have shown that there is a relative deficiency of vasopressin when ... However, omega-3 fatty acids are not recommended as immune supplements for a person with sepsis or septic shock. The usage of ... Sepsis caused by gram-positive bacteria may result from an immunological response to cell wall lipoteichoic acid. Bacterial ...

https://en.wikipedia.org/wiki/Sepsis

... endogenous antioxidants such as ascorbic acid (vitamin C), polyphenols (including flavonoids), tocopherols, etc. A few of these ... Much below that level, young salmon die from deficiency; much above, they die from toxic excess. The Occupational Safety and ... Selenous acid can also be made directly by oxidizing elemental selenium with nitric acid: 3 Se + 4 HNO 3 + H 2 O ⟶ 3 H 2 SeO 3 ... which is mixed with water and acidified to form selenous acid (oxidation step). Selenous acid is bubbled with sulfur dioxide ( ...

https://en.wikipedia.org/wiki/Selenium

... ascorbic acid and vitamin A. The lower amounts of moisture and variability in die diameter have been also known to cause this ... imbalance of certain amino acids, such as taurine and L-carnitine and potential vitamin or mineral deficiency. To offset these ... eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA). Alpha-linoleic acid is an essential fatty acid, and is the form ... Other amino acids such as cysteine, arginine, histidine, and aspartic acid have been known to decrease in availability due to ...

https://en.wikipedia.org/wiki/Vegetarian_and_vegan_dog_diet

... oxalic acid and ascorbic acid. Urine with a high specific gravity can also cause leukocyte crenation, which can impede the ... Ketonuria indicates an insulin deficiency that indicates the need to regulate its dosage. An increase in the blood ... 1) In an acid medium Para-arsanilic acid or sulphanilamide + NO− 2 → Diazonium salt 2) In an acid medium Diazonium salt + ... 1) Reaction catalysed by leukocyte esterase Indolecarboxylic acid ester → Indoxyl + Acid 2) In acid medium Indoxyl + Diazonium ...

https://en.wikipedia.org/wiki/Urine_test_strip

He conducted research on scurvy that helped lead others to the discovery that ascorbic acid is a vitamin. He discovered that ... Edward Bright Vedder (June 28, 1878 - January 30, 1952) was a U.S. Army physician, a noted researcher on deficiency diseases, ... He studied beriberi, a deficiency disease affecting the peripheral nerves, and established an extract of rice bran as its ... The experiment demonstrated conclusively that beriberi was a deficiency disease rather than the result of a toxin in the ...

https://en.wikipedia.org/wiki/Edward_Bright_Vedder

... or ascorbic acid. The experimental supplement group was compared to the malnourished group, which served as a control. The ... Nutritional deficiencies, Residential schools in Canada). ...

https://en.wikipedia.org/wiki/First_Nations_nutrition_experiments

ISBN 0-959-69092-1 Ascorbic acid, the eye, diabetes and herpes, A. Kalokerinos, Aboriginal Medical Service Information Service ... PMID 6915775 Kalokerinos A, Dettman G. (1981) "Mumps" the word but you have yet another vaccine deficiency. Australas Nurses J ...

https://en.wikipedia.org/wiki/Archie_Kalokerinos

One of the most famous iron absorption promoters is ascorbic acid. Increased ascorbic acid in the diet results in a significant ... We know that iron deficiency is a global problem and that second-best zinc supplements are more common than previously thought ... Therefore, the overexpression of ascorbic acid in plants may positively affect human iron nutrition. For example, Golden Rice ... A number of programmes have been developed to prevent and treat iron and zinc deficiency, ranging from the supplement and ...

https://en.wikipedia.org/wiki/Sustainable_Development_Goal_2

... hexuronic acid, later called ascorbic acid) which was ascorbutic vitamin. Honorary doctorate at Uppsala University (1927) ... Holst and Frølich suspected a nutritional deficiency for scurvy in the Norwegian fishing fleet, then called "shipboard beriberi ... but were unpopular within the scientific community as the concepts of nutritional deficiencies was unheard of at the time (the ...

https://en.wikipedia.org/wiki/Axel_Holst

... is also used in the treatment of cerebral folate deficiency, a syndrome in which the use of folic acid cannot ... in culture was eventually accomplished from pteroylglutamic acid in the presence of suitable concentrations of ascorbic acid. ... Folinic acid should be distinguished from folic acid (vitamin B9). However, folinic acid is a vitamer for folic acid and has ... Folinic acid is a 5-formyl derivative of tetrahydrofolic acid. It is readily converted to other reduced folic acid derivatives ...

https://en.wikipedia.org/wiki/Folinic_acid

"A preliminary trial of ascorbic acid as supplemental therapy for autism". Progress in Neuro-Psychopharmacology & Biological ... This combined with a shortage of licensed special education teachers has created a deficiency in the special education system. ... folic acid, glutathione, metallothionein promoters, other PUFA such as omega-6 fatty acids, tryptophan, tyrosine, thiamine (see ... Although omega-3 fatty acids, which are polyunsaturated fatty acids (PUFA), were 'a popular treatment for children with ASD' in ...

https://en.wikipedia.org/wiki/Autism_therapies

Sneed, S M; C Zane; M R Thomas (July 1981). "The Effects of Ascorbic Acid, Vitamin B6, Vitamin B12, and Folic Acid ... Many South Africans also have a Thiamine (Vitamin B1) deficiency. A serious deficiency in this vital nutrient can cause ... A deficiency in iron levels can lead to anemia, which is a condition classified by decreased hemoglobin levels in the blood. ... Vitamin C deficiency also has detrimental effects on the South African population. Scurvy, a disease that develops from an ...

https://en.wikipedia.org/wiki/Malnutrition_in_South_Africa

February 2004). "Effects of buffered and plain acetylsalicylic acid formulations with and without ascorbic acid on gastric ... Aspirin is known to cause hemolytic anemia in people who have the genetic disease glucose-6-phosphate dehydrogenase deficiency ... Salicylic acid is treated with acetic anhydride, an acid derivative, causing a chemical reaction that turns salicylic acid's ... Konturek PC, Kania J, Hahn EG, Konturek JW (November 2006). "Ascorbic acid attenuates aspirin-induced gastric damage: role of ...

https://en.wikipedia.org/wiki/Aspirin

Produce studies reported on ascorbic acid (vitamin C) (31 studies), beta-carotene (a precursor for vitamin A) (12 studies), and ... Studies on phytochemical composition of organic crops have numerous deficiencies, including absence of standardized ... Concentrations of phenolic acids, flavanones, stilbenes, flavones, flavonols, and anthocyanins were elevated, with flavanones ... Similarly, organic chicken contained higher levels of omega-3 fatty acids than conventional chicken. The authors found no ...

https://en.wikipedia.org/wiki/Organic_food

This enzyme deficiency allows glutaric acid, 3-hydroxyglutaric acid and to a lesser extent glutaconic acid to build up to ... Ascorbic acid is used to prevent multiple organ failure and to lessen mortality and morbidity in intensive care units. It thus ... GA1 causes secondary carnitine deficiency, as glutaric acid, like other organic acids, is detoxified by carnitine. Mental ... This includes urine organic acid analysis, looking for glutaric acid and 3-hydroxyglutaric acid. Plasma and urine acylcarnitine ...

https://en.wikipedia.org/wiki/Glutaric_aciduria_type_1

For example, ascorbic acid (vitamin C) is a vitamin for anthropoid primates, humans, guinea pigs and bats, but not for other ... Iron supplementation can lower the risk of iron deficiency anemia for pregnant women. In 2020, the World Health Organization ... fatty acids are alpha-linolenic acid (ALA), an omega-3 fatty acid, and linoleic acid (LA), an omega-6 fatty acid. ALA can be ... Fish oil is a commonly used fatty acid supplement because it is a source of omega-3 fatty acids. Fatty acids are strings of ...

https://en.wikipedia.org/wiki/Dietary_supplement

March 2012). "Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from ... February 2017). "Deficiency of microRNA miR-34a expands cell fate potential in pluripotent stem cells". Science. 355 (6325): ... "miR-34a MicroRNA Deficiency Induces Totipotent Stem Cells". Sciencebeta. 2017-01-14. Stevens LC (March 1970). "The development ... The most potent and selective compound of them (PluriSIn #1) inhibits stearoyl-coA desaturase (the key enzyme in oleic acid ...

https://en.wikipedia.org/wiki/Induced_stem_cells

Erythorbate or its equivalent ascorbic acid (vitamin C) is used to stabilize the color of cured meat. Sweeteners such as sugar ... this was at length found to be a result of cobalt deficiency in the soil.: 29 Plant toxins are also a risk to grazing animals; ... They include proteolytic enzymes, acids, salt and phosphate. Dedicated antimicrobials include lactic, citric and acetic acid, ... All muscle tissue is very high in protein, containing all of the essential amino acids, and in most cases is a good source of ...

https://en.wikipedia.org/wiki/Meat

Results of search for su:{Ascorbic acid deficiency.} Refine your search. *. Availability. * Limit to currently available ... Marginal deficiencies of thiamin, riboflavin, vitamin B-6 and vitamin C : prevalence and functional consequences in man / Eric ...

https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BAscorbic%20acid%20deficiency.%7D

Vitamin C (ascorbic acid) deficiency and excess. In: Kliegman RM, St. Geme JW, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. ...

https://medlineplus.gov/ency/article/002145.htm

Categories: Ascorbic Acid Deficiency Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...

https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Ascorbic+Acid+Deficiency&parentid=3829&catid=3586

Scurvy is a disease caused by a dietary deficiency of vitamin C (ascorbic acid). The disease has occurred with regular ...

https://www.thecanadianencyclopedia.ca/en/search?category_id=c8bb156f-d4b3-4938-bbce-7cfbfed93f2e&search=New%20France&page=4

Vitamin C deficiency. Vitamin C deficiency (ascorbic acid) has been estimated to occur in 14% of males and 10% of females in ... Common micronutrient deficiencies among refugees. Iron deficiency. Iron deficiency is the most common nutritional deficiency ... Pellagra is the deficiency of niacin and/or tryptophan, usually in combination with lack of other amino acids and ... Vitamin D deficiency. High rates of vitamin D deficiency have been reported in both resource-rich as well as resource-limited ...

https://www.cdc.gov/immigrantrefugeehealth/guidelines/domestic/nutrition-growth.html

Basically, the author states that ascorbic acid is not vitamin C. Here are some snippets. From... ... Is ascorbic acid the substance whose deficiency leads to scurvy or are thousands of experimental studies wrong? Why is ... Ascorbic acid is not a living complex. It is a copy of a part of a living complex known as vitamin C. Ascorbic acid is a ... It seems that ascorbic acid has antioxidant properties on its own but taking ascorbic acid is not the same as taking vitamin c ...

https://cassiopaea.org/forum/threads/ascorbic-acid-vitamin-c.13208/page-2

Iron deficiency. Am J Clin Nutr 1984;39:471-7. * Siegenberg D, Baynes RD, Bothwell TH, et al. Ascorbic acid prevents the dose- ... Causes of iron deficiency. Article. Summary Iron deficiency is the most common known form of nutritional deficiency. Its ... Manifestations of Iron Deficiency Iron deficiency is one of the most common nutritional deficiencies worldwide (29) and has ... Because iron deficiency is such a common cause of childhood anemia, the terms anemia, iron deficiency, and iron-deficiency ...

https://wonder.cdc.gov/wonder/prevguid/m0051880/m0051880.asp

Ascorbic Acid Deficiencies Deficiencies, Ascorbic Acid Deficiencies, Vitamin C Deficiency, Ascorbic Acid Deficiency, Vitamin C ... Ascorbic Acid Deficiencies. Deficiencies, Ascorbic Acid. Deficiencies, Vitamin C. Deficiency, Ascorbic Acid. Deficiency, ... Ascorbic Acid Deficiency - Preferred Concept UI. M0001803. Scope note. A condition due to a dietary deficiency of ascorbic acid ... Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cows milk exclusively during ...

https://decs.bvsalud.org/en/ths/resource/?id=1213&filter=ths_exact_term&q=DEFICIENCIA+DE+ACIDO+ASCORBICO

This finding might precipitate intravascular hemolysis and therapy with ascorbic acid or supportive treatment with oxygen as ... Acute retroviral syndrome presenting with hemolytic anemia induced by G6PD deficiency. Trop Med Infect Dis. 2018;4:6. DOIPubMed ... Patients with G6DP deficiency might be more vulnerable to SARS-CoV-2 infection (8). Infection of G6DP-deficient lung cells with ... Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection. J Infect Dis. 2008;197:812-6. DOIPubMed ...

https://wwwnc.cdc.gov/eid/article/26/9/20-2353_article

Ascorbic Acid Deficiency 2 0 Bronchitis 2 0 Bronchopulmonary Dysplasia 2 0 ...

https://phgkb.cdc.gov/PHGKB/huGEPedia.action?firstQuery=GSTP1&geneID=2950&typeSubmit=GO&check=y&typeOption=gene&which=2&pubOrderType=pubD

Filters: Keyword is Ascorbic Acid Deficiency and Author is Barton, Carrie L [Clear All Filters] ... "Chronic vitamin E deficiency promotes vitamin C deficiency in zebrafish leading to degenerative myopathy and impaired swimming ... "Vitamin C deficiency activates the purine nucleotide cycle in zebrafish.", J Biol Chem, vol. 287, no. 6, pp. 3833-41, 2012. ...

https://bpp.oregonstate.edu/biblio?f%5Bkeyword%5D=18106&f%5Bauthor%5D=23321&s=type&o=asc

Mucositis and oxidant injury results in micronutrient deficiency. Ascorbic acid (AA) levels were measured in 15 patients ... Reduced plasma ascorbic acid levels in recipients of myeloablative conditioning and hematopoietic cell transplantation. ...

https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=au:Simmons,+Gary

Ascorbic Acid. Diseases. Nutritional and Metabolic Diseases. Nutrition Disorders. Malnutrition. Deficiency Diseases. ...

https://phil.cdc.gov/Details.aspx?pid=14402

...

https://phil.cdc.gov/Details.aspx?pid=13569

In patients with glucose-6-phosphate dehydrogenase deficiency severe hemolysis has occurred. Ascorbic acid may interfere with ... Ascorbic acid (vitamin C) is present in human milk after maternal oral intake. Maternal oral intake of ascorbic acid (vitamin C ... Hemolysis has been reported with administration of ascorbic acid in patients with glucose-6-phosphate dehydrogenase deficiency ... Because ascorbic acid is a strong reducing agent, it can interfere with numerous laboratory tests based on oxidation-reduction ...

https://ascoriv.com/SafetyInformation

... ascorbic acid) is the most popular vitamin supplement in the United States, in many respects it is the most controversial Over ... Deficiency Signs and Symptoms. While most other animals can manufacture their own vitamin C, the human body does not have this ... Although vitamin C (ascorbic acid) is the most popular vitamin supplement in the United States, in many respects it is the most ... Nearly 70 years later, researchers are still discovering health-promoting benefits for ascorbic acid. Although scurvy is now ...

http://www.nursingreviewer.com/article/2011/07/importance-of-vitamin-c-

Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, feeling ...

https://www.meatrition.com/history/scurvy-flesh-foods

lipoic acid Pyruvate Dehydrogenase Deficiency buildup of pyruvate and alanine. reduced to lactate -, acidosis. seen in ... Ascorbic Acid. cofactor for hydroxylation of proline/lysine in collagen. facilitates Fe adsorption by keeping it reduced. ... Folic Acid Coenzyme for 1-C transfer. methylation rxns for nitrogenous bases. most common vitamin deficiency in US: macrocytic ... HGPRT deficiency -, dec IMP/GMP prod -, inc uric acid excr. retardation. self-mutilation. aggression. hyperuricemia, gout, ...

https://cueflash.com/decks/tag/acousticnelson11/tag/medicine/54401/First_Aid:_Biochemistry

Optimize ascorbic acid levels in the body to optimize immune function. ... Vitamin C deficiency treatment in Richfield - Minneapolis, MN. ... ascorbic acid), to grow and repair tissues, prevent cell damage ... Vitamin C deficiency treatment also may include vitamin C supplements to restore your bodys ascorbic acid levels, when diet ... Because a deficiency in vitamin C usually stems from a lack of vitamin C in your diet, avoiding a vitamin C deficiency and ...

https://www.internal-medicine-centers.com/richfield/minneapolis/vitamin-c-deficiency-treatment.html

If you have an allergy to ascorbic acid or any other part of Protexin (ascorbic acid (vitamin C) solution, liquid, and syrup). ... Be careful if you have G6PD deficiency. Anemia may happen. *Tell your doctor if you are pregnant or plan on getting pregnant. ... If you are allergic to Protexin (ascorbic acid (vitamin C) solution, liquid, and syrup); any part of Protexin (ascorbic acid ( ... ascorbic acid (vitamin C) solution, liquid, and syrup). *Keep taking Protexin (ascorbic acid (vitamin C) solution, liquid, and ...

https://www.drugs.com/cdi/protexin.html

Scurvy occurs due to a deficiency in vitamin C (ascorbic acid) in the body and is considered a metabolic disease of the bone, ... Diet, nutritional deficiency and stress. To better understand diet and nutritional deficiency in the context of socioeconomic ... Waters-Rist, A.L. and Hoogland, M.L., (2018). The Role of Infant Feeding and Childhood Diet in Vitamin D Deficiency in a ... 2009, 112) have proposed megaloblastic anaemia or the deficiencies of vitamin B9 and B12 as the likely cause of cribra ...

https://theposthole.org/read/article/463

To determine the levels of ascorbic acid in mango flour, an extraction solution was prepared (15 g metaphosphoric acid: 40 mL ... with positive effects in terms of antioxidation and prevention of vitamin A deficiency (Liang et al., 2020Liang, M., Su, X., ... Acid ascorbic (mg/100 g). MPeF. 99.0 ± 4.19Bb 103.6 ± 2.9Bb 136.4 ± 7.7Aa 97.4 ± 3.23Ba ... To quantify the ascorbic acid content, the extract was titrated using indophenol dye (50 mg dye, 42 mg NaHCO3, and 200 mL water ...

https://www.scielo.br/j/cta/a/gQ8fGrdNbRm9VrhqGSBXFCM/?lang=en

... deficiency anemias (281.-) 266.9 Unspecified vitamin B deficiency 267 Ascorbic acid deficiency Deficiency of vitamin C Scurvy ... Protein-deficiency anemia Amino-acid-deficiency anemia 281.8 Anemia associated with other specified nutritional deficiency ... Deficiency of vitamin K Excludes: deficiency of coagulation factor due to vitamin K deficiency (286.7) vitamin K deficiency of ... Deficiency of B-complex components 266.0 Ariboflavinosis Riboflavin deficiency 266.1 Vitamin B6 deficiency Deficiency: ...

https://ftp.cdc.gov/pub/Health_Statistics/nchs/Publications/ICD-9/ucod.txt

What is Vitamin C or Ascorbic Acid used for? Ascorbic acid supplementation helps in reducing Vitamin C deficiency. Increasing ... L-Ascorbic Acid Ascorbic acid also known as L-Ascorbic Acid is vitamin C which is naturally found in various foods. It is also ... Ascorbic acid L-Ascorbic Acid (CAS No.: 50-81-7) Vitamin C is also known as Ascorbic Acid or Ascorbate in the dietary ... Ascorbic acid »MCT Oil - Essentials »An insight to Plant Based or Vegan proteins ...

https://aapharmachem.com/blog/

... and between maternal ascorbic and cord blood ascorbic acid concentrations (r = 0.56, P = 0.001). ... ABSTRACT Micronutrient deficiencies exist among women of childbearing age in the United Arab Emirates but the effects of ... The median serum ascorbic acid and 25-OHD concentrations were very low while the serum retinol and α-tocopherol concentrations ... Ascorbic acid concentrations in umbilical cord veins and arteries of preterm and term newborns. Biology of the neonate, 1995, ...

https://www.emro.who.int/emhj-volume-15-2009/volume-15-issue-6/current-maternalinfant-micronutrient-status-and-the-effects-on-birth-weight-in-the-united-arab-emirates.html

Apple juice vinegar, for example, is high in nutrients and minerals such as L-ascorbic acid, folic acid, and niacin, all of ... and resolving deficiencies. According to a review published in Logical Reports, it also includes antimicrobials that kill ... It also contains L-ascorbic acid, which may help with promoting healing in the body, strengthening resistance, ... These ACV candies are a tasty and easy way to get some vitamins, minerals, and acids into your system - and into ketosis. ...

https://theamberpost.com/post/keto-clean-gummies-increase-ketosis-for-faster-fat-burn

IMMUNOGARD is for the treatment and prevention of Vitamin C and Zinc deficiencies, it helps strengthen the immune system of the ... IMMUNOGARD is a nutritional supplement containing 500mg of Ascorbic Acid (equivalent to 568.18mg Sodium Ascorbate) and 10mg ... 2 Immunogard Ascorbic Acid (As SODIUM ASCORBATE 568.18mg) +Zinc 10mg 100s + FREE House of Sage Pill Pouch. * Sale ... IMMUNOGARD is a nutritional supplement containing 500mg of Ascorbic Acid (equivalent to 568.18mg Sodium Ascorbate) and 10mg ...

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Vitamin C, also known as ascorbic acid, is a nutrient essential for healing your body and can help a strong immune system. ... Since the body doesnt produce vitamin C, it is easy to suffer from vitamin C deficiency if your diet doesnt include fruits ... If you have sensitive skin, it is recommended to avoid skincare products with L-ascorbic acid. Try serums and creams with ...

https://www.biotherm.ca/en/best-skincare-ingredient-vitamin-c.html

Ascorbic acid deficiency gives rise to the appearance of scurvy. (nih.gov)
www.thecanadianencyclopedia.ca/en/article/scurvy. (thecanadianencyclopedia.ca)
Scurvy is a disease caused by a dietary deficiency of vitamin C (ascorbic acid). (thecanadianencyclopedia.ca)
Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. (nih.gov)
For vitamin C, this is the amount necessary to prevent scurvy, a disease caused by vitamin C deficiency. (nih.gov)
Many people associate to terms scurvy, pellagra, beriberi, rickets or ariboflavinosis with dietary deficiency. (nih.gov)
Throughout history humans have suffered from the vitamin C-deficiency disease known as scurvy. (nursingreviewer.com)
In 1742, British physician James Lind wrote the first real scientific discussion about the possibility that scurvy was a dietary deficiency. (nursingreviewer.com)
Although scurvy is now rare in our society, subclinical or marginal vitamin C deficiency is common, especially in the elderly. (nursingreviewer.com)
Scurvy is a disease resulting from a lack of vitamin C (ascorbic acid). (meatrition.com)
Scurvy is a condition characterised by general weakness, anaemia, gingivitis (gum disease), and skin haemorrhages caused by a prolonged deficiency of vitamin C in the diet. (ozarcare.com)
Known colloquially as scurvy, a diminutive of the Latin word scorbutus, severe vitamin C deficiency derives from a dearth of vitamin C in the diet. (internal-medicine-centers.com)
Similarities between the symptoms of copper deficiency in animals and scurvy in humans would tend to suggest that there is a mutual synergism between ascorbic acid and copper. (robertbarrington.net)

Remediation of ascorbate deficiency in tissue culture restores the physiological state of many cellular processes and it should improve a currently limited toxicity predictability of in vitro bioassays. (nih.gov)
L-Ascorbic Acid (CAS No.: 50-81-7) Vitamin C is also known as Ascorbic Acid or Ascorbate in the dietary supplement industry. (aapharmachem.com)
IMMUNOGARD is a nutritional supplement containing 500mg of Ascorbic Acid (equivalent to 568.18mg Sodium Ascorbate) and 10mg Elemental Zinc (equivalent to 27.5mg Zinc Sulfate Monohydrate). (vpharma.ph)
In high ascorbate conditions, only 33% of copper can be immunoprecipitated with antibodies to superoxide dismutase, but when ascorbic acid is absent, 94% of the copper is immunoprecipitable. (robertbarrington.net)

More recent results show that intracellular ascorbic acid also prevents the increase in endothelial barrier permeability caused by high glucose concentrations. (nih.gov)
The mechanism of this barrier protection is proposed to involve ascorbic acid scavenging of reactive oxygen species generated in response to high glucose concentrations, as well as ascorbic acid recycling of tetrahydrobiopterin to prevent uncoupling of endothelial nitric oxide synthase. (nih.gov)
This hypothesis and mechanism will be tested in endothelial cells cultured at hyperglycemic glucose concentrations and extended to novel mouse models of ascorbic acid deficiency or repletion in the context of streptozotocin-induced diabetes. (nih.gov)
The first aim asks how physiologic ascorbic acid concentrations support basal nitric oxide generation in endothelial cells and whether this contributes to the ability of the vitamin to tighten the endothelial barrier to passage of large molecules. (nih.gov)
The second aim tests how ascorbic acid prevents endothelial barrier failure caused by high glucose concentrations, again with focus on a mechanism involving ascorbic acid prevention of uncoupling of nitric oxide synthase. (nih.gov)
Since many of the deleterious effects of high glucose concentrations are caused by activation of the Receptor for Advanced Glycation End-products (RAGE), the third aim will test the mechanism by which ascorbic acid prevents increased endothelial permeability due to RAGE ligands. (nih.gov)
The fourth aim will extend the in vitro studies to novel mouse models in which ascorbic concentrations can be manipulated by dietary and genetic means to test effects of increased oxidative stress due to streptozotocin- induced diabetes. (nih.gov)
Ascorbic acid may acidify the urine and lower serum concentrations of amphetamine by increasing renal excretion (as reflected by changes in amphetamine urine recovery rates). (ascoriv.com)
It has been reported that concurrent administration of ascorbic acid and fluphenazine has resulted in decreased fluphenazine plasma concentrations. (ascoriv.com)

Vitamin C deficiency treatment also may include vitamin C supplements to restore your body's ascorbic acid levels, when diet alone fails in doing so. (internal-medicine-centers.com)

Apple juice vinegar, for example, is high in nutrients and minerals such as L-ascorbic acid, folic acid, and niacin, all of which are powerful cancer-prevention agents that help to eliminate free radicals and relieve oxidative pressure. (theamberpost.com)

Vitamin C Chewable Tablet With Zinc is a supplement of vitamin C (ascorbic acid) that restores the nutritional deficiency of vitamin C in the body and helps improve an individual's overall health. (ozarcare.com)

Deficiency diseases may be classified into two groups, primary malnutrition. (nih.gov)
Folate deficiency diseases, which are common in this category, are said to have a higher incidence in the south than in most other sections. (nih.gov)

Our research focuses on vitamin C (ascorbic acid) as a model nutrient. (nih.gov)
We seek a functional basis for nutrient recommendations, rather than relying on preventing deficiency-the previous method used for many years. (nih.gov)
For many years, they have based these on the least amount of the nutrient needed to prevent clinical deficiency. (nih.gov)
Your body relies on an essential nutrient, vitamin C (ascorbic acid), to grow and repair tissues, prevent cell damage and produce collagen and blood vessels. (internal-medicine-centers.com)
Vitamin C, also known as ascorbic acid, is a nutrient essential for healing your body and can help a strong immune system. (biotherm.ca)

Ascorbic acid supplementation helps in reducing Vitamin C deficiency. (aapharmachem.com)
The order of ascorbic acid supplementation or non-supplementation will be decided by random. (clinicaltrials.gov)

Bleomycin is inactivated in vitro by ascorbic acid. (ascoriv.com)

Abstract: DESCRIPTION (provided by applicant): Plasma and cell levels of vitamin C, or ascorbic acid, are decreased about 50% in persons with type II diabetes in sub-optimal glycemic control, despite presumably adequate dietary intakes. (nih.gov)

Iron deficiency is the most common known form of nutritional deficiency. (cdc.gov)
To better understand diet and nutritional deficiency in the context of socioeconomic status, metabolic disease and non-specific indicators of stress must be fully explored. (theposthole.org)

Acute and chronic oxalate nephropathy have been reported with prolonged administration of high doses of ascorbic acid. (ascoriv.com)
Limited case reports have suggested interference of ascorbic acid with the anticoagulation effects of warfarin, however, patients on warfarin therapy treated with ascorbic acid doses up to 1000 mg/day (5 times the largest recommended single dose) for 2 weeks (twice the maximum recommended duration), no effect was observed. (ascoriv.com)
Kidney stones or other very bad kidney problems have rarely happened in people taking high doses of Protexin (ascorbic acid (vitamin C) solution, liquid, and syrup) for a long time. (drugs.com)

Marginal deficiencies of thiamin, riboflavin, vitamin B-6 and vitamin C : prevalence and functional consequences in man / Eric Jan van der Beek. (who.int)

G6PD deficiency can induce methemoglobinemia by inhibiting NADPH-flavine reductase, which prevents the reduction of methemoglobin. (cdc.gov)
Testing of patient with G6PD deficiency and SARS-CoV-2 infection, United Kingdom. (cdc.gov)
Be careful if you have G6PD deficiency. (drugs.com)

It is known experimentally hat copper deficient animals can have their lives shortened by adding 0.1 to 1% ascorbic acid to their diets, which worsens the copper deficiency symptoms in the animals. (robertbarrington.net)

Vitamin C or ascorbic acid is a hydrosoluble vitamin derived from glucose metabolism. (nih.gov)
This decrease is due to oxidative stress from excess glucose and fatty acid metabolism. (nih.gov)
We report a case of intravascular hemolysis and methemoglobinemia, precipitated by severe acute respiratory syndrome coronavirus 2 infection, in a patient with undiagnosed glucose-6-phosphate dehydrogenase deficiency. (cdc.gov)
Glucose 6‐phosphate dehydrogenase (G6DP) deficiency is an X-linked enzymatic disorder that affects 400 million persons worldwide and has a high prevalence (5%-20%) in African and Asian populations ( 2 ). (cdc.gov)
Facilitated glucose transporters mediate transport of the oxidation product of ascorbic acid, dehydroascorbic acid. (nih.gov)
Hemolysis has been reported with administration of ascorbic acid in patients with glucose-6-phosphate dehydrogenase deficiency. (ascoriv.com)
Patients with glucose-6-phosphate dehydrogenase deficiency may be at increased risk for severe hemolysis during treatment with ascorbic acid. (ascoriv.com)
Monitor hemoglobin and blood count and use a reduced dose of ASCOR ® in patients with glucose-6-phosphate dehydrogenase deficiency. (ascoriv.com)
Ascorbic acid may interfere with laboratory tests based on oxidation-reduction reactions, including blood and urine glucose testing, nitrite and bilirubin levels, and leucocyte count testing. (ascoriv.com)
Because ascorbic acid is a strong reducing agent, it can interfere with numerous laboratory tests based on oxidation-reduction reactions (e.g. glucose, nitrite and bilirubin levels, leukocyte count, etc. (ascoriv.com)

Deficiency of the vitamin causes a breakdown in the binding function of these tissues, producing a series of characteristic signs and symptoms: weakness, lethargy, irritability, anemia, purple spongy gums which bleed freely, loosening teeth, the reopening of healed scars (including refracturing of bone) and hemorrhaging in the mucous membranes and skin. (thecanadianencyclopedia.ca)
You may not notice the symptoms of iron deficiency anemia. (healthlinkbc.ca)
To diagnose iron deficiency anemia, your doctor will do a physical examination and ask about your health and symptoms. (healthlinkbc.ca)
Early symptoms of deficiency include weakness, feeling tired and sore arms and legs. (meatrition.com)
Your healthcare provider can identify vitamin C deficiency by the symptoms with which you present during a physical exam and can confirm the deficiency by administering a blood test to measure vitamin C levels. (internal-medicine-centers.com)

In the past three decades, increased iron intake among infants has resulted in a decline in childhood iron-deficiency anemia in the United States. (cdc.gov)
In the United States, the prevalence of iron-deficiency anemia among children declined during the 1970s in association with increased iron intake during infancy (1-3). (cdc.gov)
CDC requested the Institute of Medicine to convene an expert committee to develop recommendations for preventing, detecting, and treating iron-deficiency anemia among U.S. children and U.S. women of childbearing age. (cdc.gov)
Iron deficiency anemia means that your body does not have enough iron. (healthlinkbc.ca)
Iron deficiency anemia means that your body doesn't have enough iron to make red blood cells . (healthlinkbc.ca)
Iron deficiency anemia is caused by low levels of iron in the body. (healthlinkbc.ca)
How is iron deficiency anemia treated? (healthlinkbc.ca)
To treat iron deficiency anemia, your doctor will try to find the cause of the anemia and treat that problem. (healthlinkbc.ca)
You can help prevent iron deficiency anemia by eating iron-rich foods every day. (healthlinkbc.ca)
Bleeding inside the body is the most common cause of iron deficiency anemia in men and in women after menopause. (healthlinkbc.ca)

This leads to the main hypothesis of this proposal that ascorbic acid helps to maintain endothelial barrier function in vivo and especially in the face of diabetes-induced oxidative stress. (nih.gov)
Key to his aim is to assess whether diabetes-induced oxidative stress and subsequent endothelial dysfunction is worsened by depletion of ascorbic acid and reversed by its repletion. (nih.gov)
G6DP deficiency increases the risk for intravascular hemolysis upon exposure to oxidative agents, such as fava beans, sulfonamides, and hydroxychloroquine, the subject of clinical trials for persons with SARS-CoV-2 infection. (cdc.gov)

As a consequence, the use of screening tests for anemia has become a less efficient means of detecting iron deficiency in some populations. (cdc.gov)
These recommendations update the 1989 'CDC Criteria for Anemia in Children and Childbearing-Aged Women' (MMWR 1989;38(22):400-4) and are the first comprehensive CDC recommendations to prevent and control iron deficiency. (cdc.gov)
Because of this decline, the value of anemia as a predictor of iron deficiency has also declined, thus decreasing the effectiveness of routine anemia screening among children. (cdc.gov)
Iron deficiency is the most common cause of anemia. (healthlinkbc.ca)
El síndrome urémico hemolítico (SUH), descripto en 1955, se caracteriza por la tríada de anemia hemolítica no inmunomediada, trombocitopenia y lesión renal aguda. (bvsalud.org)

By primary malnutrition, we refer to deficiency states due to inadequate intake alone. (nih.gov)
By secondary or conditioned malnutrition, we mean deficiency states produced by factors other than an inadequate diet. (nih.gov)

However, the role of ascorbic acid on copper metabolism is not limited to the gastrointestinal tract, and there is evidence to suggest that ascorbic acid plays an important role in copper transport and cellular uptake. (robertbarrington.net)

occurs when you have a severe lack of vitamin C ( ascorbic acid ) in your diet. (nih.gov)

Deficiency of some vitamins and minerals can cause DNA damage. (nih.gov)

Hyaluronic Acid (CAS # 9004-61-9) is a dietary supplement made by using synthesized forms of the compound. (aapharmachem.com)
Hyaluronic acid is found naturally in the human body. (aapharmachem.com)

Ferrous fumarate (a form of iron) is often added to foods in an effort to prevent iron deficiency. (clinicaltrials.gov)
They will consume a meal of a bread muffin labelled with 4mg of iron-57 as ferrous fumarate, and a glass of apple juice containing 0 or 25mg ascorbic acid. (clinicaltrials.gov)

Humans cannot synthesize ascorbic acid as they lack an enzyme called gulonolactone oxidase. (nih.gov)
Ascorbic acid is thought to interact with copper in the gastrointestinal tract of humans and decrease the absorption of the mineral. (robertbarrington.net)

A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. (nih.gov)

Ascorbic acid , or vitamin C, aids in many functions of the body, including the absorption of iron. (nih.gov)
When isolated into artificial commercial forms, like ascorbic acid, these purified synthetics act as drugs in the body. (cassiopaea.org)
It is used if the diet does not provide enough vitamin C and to manage certain conditions caused due to vitamin C deficiency in the body. (ozarcare.com)
Triglycerides are formed by joining three fatty acids to a glycerin backbone by the body. (aapharmachem.com)
It also contains L-ascorbic acid, which may help with promoting healing in the body, strengthening resistance, and resolving deficiencies. (theamberpost.com)
Since the body doesn't produce vitamin C, it is easy to suffer from vitamin C deficiency if your diet doesn't include fruits and vegetables. (biotherm.ca)

Acidification of the urine by ascorbic acid may cause precipitation of cysteine, urate or oxalate stones. (ascoriv.com)
In addition, acidification of urine by ascorbic acid will alter the excretion of certain drugs affected by the pH of the urine (e.g. fluphenazine) when administered concurrently. (ascoriv.com)

Bone and connective tissue defects, anaemia and subcutaneous haemorrhaging are seen in both deficiency states. (robertbarrington.net)

L-Tyrosine (CAS# 60-18-4) is a type of amino acid and dietary supplement that is growing in use. (aapharmachem.com)
Carnitine or L- Carnitine Base is a form of Amino Acid and is used a dietary supplement. (aapharmachem.com)

Moreover, modification by ascorbic acid may facilitate application of hpESCs to clinical settings in the future by enhancing their pluripotency. (biomedcentral.com)
Ceruoplasmin is know to undergo reactions in response to reducing agents such as ascorbic acid, which may facilitate the exchange of copper from ceruoplasmin to cells. (robertbarrington.net)

Typically, MCT oil and MCT oil powder is processed from Coconut and contains unique fatty acids. (aapharmachem.com)
Unsaturated fats are mostly shorter-chain fatty acids consisting of 8 to 14 carbons. (aapharmachem.com)
Saturated fats are mostly long-chain fatty acids consisting of 16 to 20 carbons. (aapharmachem.com)

Ascorbic acid is thought to decrease copper absorption because it reduces copper from its cupric state (Cu 2+ ) to its less absorbable cuprous state (Cu 1+ ). (robertbarrington.net)

Ascorbic Acid in Cancer Treatment: Let the Phoenix Fly. (nih.gov)
This presentation is designed to clarify and simplify some of the newer aspects of nutrition for the practicing physician with special emphasis on diagnosis and treatment of vitamin deficiency states. (nih.gov)
Patients with renal disease including renal impairment, history of oxalate kidney stones, and geriatric patients may be at increased risk for oxalate nephropathy while receiving treatment with ascorbic acid. (ascoriv.com)
Pediatric patients less than 2 years of age may be at increased risk for oxalate nephropathy during treatment with ascorbic acid because their kidneys are immature. (ascoriv.com)
Standard monitoring for anti-coagulation therapy should continue during ascorbic acid treatment, as per standard of care. (ascoriv.com)
If you suspect you are suffering from insufficient levels of vitamin C, it is important to meet with a healthcare provider who can determine the underlying cause of your vitamin C deficiency and develop a treatment plan that addresses your body's unique needs. (internal-medicine-centers.com)
Schedule a consultation with a qualified healthcare provider in Richfield - Minneapolis that specializes in vitamin C deficiency treatment . (internal-medicine-centers.com)
Treatment with ascorbic acid, rescued their ability to support teratoma formation and altered the expression profiles of paternally expressed genes in hpESCs that could not form teratoma easily. (biomedcentral.com)
IMMUNOGARD is for the treatment and prevention of Vitamin C and Zinc deficiencies, it helps strengthen the immune system of the consumers especially through the pandemic. (vpharma.ph)

Vitamin C (ascorbic acid) deficiency and excess. (medlineplus.gov)

ascorbic acid protects the functional parts of the vitamin from rapid oxidation or breakdown. (cassiopaea.org)

The ascorbic acid you buy at the grocery store every few weeks, thinking you are buying Vitamin C, is just a chemical copy of naturally occurring ascorbic acid, which itself is still only a fraction of the actual Vitamin C. Real vitamin C is part of something living, and as such, can impart life. (cassiopaea.org)

You must check to make sure that it is safe for you to take Protexin (ascorbic acid (vitamin C) solution, liquid, and syrup) with all of your drugs and health problems. (drugs.com)

To address the changing epidemiology of iron deficiency in the United States, CDC staff in consultation with experts developed new recommendations for use by primary health-care providers to prevent, detect, and treat iron deficiency. (cdc.gov)
These findings, plus increased knowledge about screening for iron status, raised questions about the necessity and effectiveness of existing U.S. programs to prevent and control iron deficiency. (cdc.gov)
Alternatively, ascorbic acid may inhibit the binding of copper to metallothionein and delay or prevent its absorption through the intestinal mucosa. (robertbarrington.net)

On going multiple clinical trials in cancer and sepsis using pharmacologic ascorbic acid are based on our work. (nih.gov)

Deficiency in vitamin C may accompany wars and famine, but it is most commonly associated with post-Renaissance European exploration , particularly ocean voyages. (thecanadianencyclopedia.ca)
Rickets is most commonly linked with a lack of sunlight exposure, rather than a dietary deficiency. (theposthole.org)

Results of search for 'su:{Ascorbic acid deficiency. (who.int)

Iron deficiency is a common health problem worldwide. (clinicaltrials.gov)

The above adverse reactions associated with the use of ascorbic acid were identified in the literature. (ascoriv.com)

A hydroxylated form of the imino acid proline. (bvsalud.org)
Fish were fed 1 of 11 semi-purified diets containing equivalent of 0, 50, 100, 200, 400, and 800 mg ascorbic acid (AA)/kg diet in the form of AMP-Ca or AMP-Na/Ca for 12 weeks. (usda.gov)

Cell studies have shown that ascorbic acid stimulates the uptake of copper from ceruoplasmin to cultured cells by approximately 10-fold, suggesting a role for ascorbic acid in cellular copper uptake. (robertbarrington.net)

Anatomy1

Organisms3

Diseases10

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes2

Dietary antioxidants and magnesium in type 1 brittle asthma: a case control study. (1/213)

Parenteral vitamin requirements during intravenous feeding. (2/213)

Aortic wall damage in mice unable to synthesize ascorbic acid. (3/213)

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. (4/213)

Plasma vitamin C and food choice in the third Glasgow MONICA population survey. (5/213)

Vitamin C status and mortality in US adults. (6/213)

Oral contraceptives and ascorbic acid. (7/213)

Fractured neck of femur in black patients: a prospective study. (8/213)

Ascorbic Acid Deficiency

Scurvy

Ascorbic Acid

Rats, Mutant Strains

Fatty Acids, Essential

Haptoglobins

Folic Acid Deficiency

Liver

Apolipoprotein A-I

Deficiency Diseases

Body Weight

Anemia, Macrocytic

Blotting, Northern

Methemoglobinemia

SARS Virus

Glucosephosphate Dehydrogenase Deficiency

Severe Acute Respiratory Syndrome

Spike Glycoprotein, Coronavirus

Hemolysis

Coronavirus

Dietary antioxidants and magnesium in type 1 brittle asthma: a case control study. (1/213)

Parenteral vitamin requirements during intravenous feeding. (2/213)

Aortic wall damage in mice unable to synthesize ascorbic acid. (3/213)

Ascorbate is depleted by smoking and repleted by moderate supplementation: a study in male smokers and nonsmokers with matched dietary antioxidant intakes. (4/213)

Plasma vitamin C and food choice in the third Glasgow MONICA population survey. (5/213)

Vitamin C status and mortality in US adults. (6/213)

Oral contraceptives and ascorbic acid. (7/213)

Fractured neck of femur in black patients: a prospective study. (8/213)

Gamma-butyrobetaine dioxygenase

Vitamin C megadosage

Periodontal fiber

Mountain ration

Protein primary structure

Argument from poor design

Hugh Macdonald Sinclair

Canadian health claims for food

Atrophic gastritis

Vitamin C

Myxobolus cerebralis

Scurvy

Iron-deficiency anemia

Chemistry of ascorbic acid

Vitamin C (disambiguation)

Dopamine beta hydroxylase deficiency

Almroth Wright

Mercury regulation in the United States

L-gulonolactone oxidase

Lipoprotein(a)

Diiodohydroxyquinoline

Hydroxylation

History of military nutrition in the United States

Staple food

History of life

Dopamine

Plateau principle

Latent iron deficiency

Tetrahydrobiopterin

Jagannath Ganguly

Tudor Rickards

African nightshade

Glucose meter

Ozone

Oxidative stress

Alkaptonuria

Hans Konrad Biesalski

Complications of diabetes

Sepsis

Selenium

Vegetarian and vegan dog diet

Urine test strip

Edward Bright Vedder

First Nations nutrition experiments

Archie Kalokerinos

Sustainable Development Goal 2

Axel Holst

Folinic acid

Autism therapies

Malnutrition in South Africa

Aspirin

Organic food