A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into SCURVY in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
The reversibly oxidized form of ascorbic acid. It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion.
An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
An enzyme involved in the metabolism of ASCORBIC ACID and aldarate. It catalyzes the oxidation of L-gulono-1,4-lactone to L-xylo-hex-3-ulonolactone.
Membrane transport proteins that actively co-transport ASCORBIC ACID and sodium ions across the CELL MEMBRANE. Dietary absorption of VITAMIN C is highly dependent upon this class of transporters and a subset of SODIUM GLUCOSE TRANSPORTERS which transport the oxidized form of vitamin C, DEHYDROASCORBIC ACID.
An enzyme that converts ascorbic acid to dehydroascorbic acid. EC
Metabolite of ASCORBIC ACID and the oxidized form of the lactone DEHYDROASCORBIC ACID.
A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).
Rats bearing mutant genes which are phenotypically expressed in the animals.
Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Inorganic derivatives of phosphorus trihydroxide (P(OH)3) and its tautomeric form dihydroxyphosphine oxide (HP=O(OH)2). Note that organic derivatives of phosphonic acids are listed under are ORGANOPHOSPHONATES.
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.
A natural tocopherol and one of the most potent antioxidant tocopherols. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. It has four methyl groups on the 6-chromanol nucleus. The natural d form of alpha-tocopherol is more active than its synthetic dl-alpha-tocopherol racemic mixture.
Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.
Organelles in CHROMAFFIN CELLS located in the adrenal glands and various other organs. These granules are the site of the synthesis, storage, metabolism, and secretion of EPINEPHRINE and NOREPINEPHRINE.
Regular course of eating and drinking adopted by a person or animal.
A strong dicarboxylic acid occurring in many plants and vegetables. It is produced in the body by metabolism of glyoxylic acid or ascorbic acid. It is not metabolized but excreted in the urine. It is used as an analytical reagent and general reducing agent.
Inorganic or organic compounds that contain divalent iron.
Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.
Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.
The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.
Electric conductors through which electric currents enter or leave a medium, whether it be an electrolytic solution, solid, molten mass, gas, or vacuum.
The study of chemical changes resulting from electrical action and electrical activity resulting from chemical changes.
A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
The cells of the body which stain with chromium salts. They occur along the sympathetic nerves, in the adrenal gland, and in various other organs.
The dialdehyde of malonic acid.
A flavonol glycoside found in many plants, including BUCKWHEAT; TOBACCO; FORSYTHIA; HYDRANGEA; VIOLA, etc. It has been used therapeutically to decrease capillary fragility.
A colorless to white crystalline compound with a camphoraceous odor and taste. It is a widely used preservative in various pharmaceutical solutions, especially injectables. Also, it is an active ingredient in certain oral sedatives and topical anesthetics.
Compounds in which one or more of the ketone groups on the pyrimidine ring of barbituric acid are replaced by thione groups.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Organic substances that are required in small amounts for maintenance and growth, but which cannot be manufactured by the human body.
A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)
A plant family of the order Polygalales, subclass Rosidae class, Magnoliopsida that are mostly shrubs and small trees. Many of the members contain indole alkaloids.
A subclass of ORGANIC ANION TRANSPORTERS whose transport of organic anions is driven either directly or indirectly by a gradient of sodium ions.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.
Reversibly catalyzes the oxidation of a hydroxyl group of sugar alcohols to form a keto sugar, aldehyde or lactone. Any acceptor except molecular oxygen is permitted. Includes EC 1.1.1.; EC 1.1.2. and EC 1.1.99.
Iron or iron compounds used in foods or as food. Dietary iron is important in oxygen transport and the synthesis of the iron-porphyrin proteins hemoglobin, myoglobin, cytochromes, and cytochrome oxidase. Insufficient amounts of dietary iron can lead to iron-deficiency anemia.
The rate dynamics in chemical or physical systems.
Complexing agent for removal of traces of heavy metal ions. It acts also as a hypocalcemic agent.
Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)
A drug-metabolizing, cytochrome P-450 enzyme which catalyzes the hydroxylation of aniline to hydroxyaniline in the presence of reduced flavoprotein and molecular oxygen. EC 1.14.14.-.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
A group of compounds that contain a bivalent O-O group, i.e., the oxygen atoms are univalent. They can either be inorganic or organic in nature. Such compounds release atomic (nascent) oxygen readily. Thus they are strong oxidizing agents and fire hazards when in contact with combustible materials, especially under high-temperature conditions. The chief industrial uses of peroxides are as oxidizing agents, bleaching agents, and initiators of polymerization. (From Hawley's Condensed Chemical Dictionary, 11th ed)
The inner portion of the adrenal gland. Derived from ECTODERM, adrenal medulla consists mainly of CHROMAFFIN CELLS that produces and stores a number of NEUROTRANSMITTERS, mainly adrenaline (EPINEPHRINE) and NOREPINEPHRINE. The activity of the adrenal medulla is regulated by the SYMPATHETIC NERVOUS SYSTEM.
Low-molecular-weight end products, probably malondialdehyde, that are formed during the decomposition of lipid peroxidation products. These compounds react with thiobarbituric acid to form a fluorescent red adduct.
Elements of limited time intervals, contributing to particular results or situations.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.
A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.
Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.

Double-blind intervention trial on modulation of ozone effects on pulmonary function by antioxidant supplements. (1/4830)

The aim of this study was to investigate whether the acute effects of ozone on lung function could be modulated by antioxidant vitamin supplementation in a placebo-controlled study. Lung function was measured in Dutch bicyclists (n = 38) before and after each training session on a number of occasions (n = 380) during the summer of 1996. The vitamin group (n = 20) received 100 mg of vitamin E and 500 mg of vitamin C daily for 15 weeks. The average ozone concentration during exercise was 77 microg/m3 (range, 14-186 microg/m3). After exclusion of subjects with insufficient compliance from the analysis, a difference in ozone exposure of 100 microg/m3 decreased forced expiratory volume in 1 second (FEV1) 95 ml (95% confidence interval (CI) -265 to -53) in the placebo group and 1 ml (95% CI -94 to 132) in the vitamin group; for forced vital capacity, the change was -125 ml (95% CI -384 to -36) in the placebo group and -42 ml (95% CI -130 to 35) in the vitamin group. The differences in ozone effect on lung function between the groups were statistically significant. The results suggest that supplementation with the antioxidant vitamins C and E confers partial protection against the acute effects of ozone on FEV1 and forced vital capacity in cyclists.  (+info)

Thiol-dependent degradation of protoporphyrin IX by plant peroxidases. (2/4830)

Protoporphyrin IX (PP) is the last porphyrin intermediate in common between heme and chlorophyll biosynthesis. This pigment normally does not accumulate in plants because its highly photodynamic nature makes it toxic. While the steps leading to heme and chlorophylls are well characterized, relatively little is known of the metabolic fate of excess PP in plants. We have discovered that plant peroxidases can rapidly degrade this pigment in the presence of thiol-containing substrates such as glutathione and cysteine. This thiol-dependent degradation of PP by horseradish peroxidase consumes oxygen and is inhibited by ascorbic acid.  (+info)

Stabilization of L-ascorbic acid by superoxide dismutase and catalase. (3/4830)

The effects of superoxide dismutase (SOD) and catalase on the autoxidation rate of L-ascorbic acid (ASA) in the absence of metal ion catalysts were examined. The stabilization of ASA by SOD was confirmed, and the enzyme activity of SOD, which scavenges the superoxide anion formed during the autoxidation of ASA, contributed strongly to this stabilization. The stabilization of ASA by catalase was observed for the first time; however, the specific enzyme ability of catalase would not have been involved in the stabilization of ASA. Such proteins as bovine serum albumin (BSA) and ovalbumin also inhibited the autoxidation of ASA, therefore it seems that non-specific interaction between ASA and such proteins as catalase and BSA might stabilize ASA and that the non-enzymatic superoxide anion scavenging ability of proteins might be involved.  (+info)

Glutathione-S-transferase (GSTM1) genetic polymorphisms do not affect human breast cancer risk, regardless of dietary antioxidants. (4/4830)

Glutathione-S-transferases catalyze the detoxication of carcinogen metabolites and reactive oxygen species (ROS) produced through a number of mechanisms. Glutathione-S-transferase (GST) M1 is polymorphic, and the null allele results in a lack of enzyme activity. Because there are indications that ROS may be involved in breast carcinogenesis, we sought to determine whether the GSTM1 null allele was associated with increased breast cancer, particularly among women with lower consumption of dietary sources of alpha-tocopherol, carotenoids and ascorbic acid. In a study of diet and cancer in western New York, women with primary, incident, histologically confirmed breast cancer (n = 740) and community controls (n = 810) were interviewed and an extensive food-frequency questionnaire administered. A subset of these women provided a blood specimen. DNA was extracted and genotyping performed for GSTM1. Data were available for 279 cases and 340 controls. The null allele did not increase breast cancer risk, regardless of menopausal status. There were also no differences in associations between the polymorphism and risk among lower and higher consumers of dietary sources of antioxidants or smokers and nonsmokers. These results indicate that GSTM1 genetic polymorphisms are not associated with breast cancer risk, even in an environment low in antioxidant defenses.  (+info)

Prospective cohort study of antioxidant vitamin supplement use and the risk of age-related maculopathy. (5/4830)

In a prospective cohort study, the authors examined whether self-selection for antioxidant vitamin supplement use affects the incidence of age-related maculopathy. The study population consisted of 21,120 US male physician participants in the Physicians' Health Study I who did not have a diagnosis of age-related maculopathy at baseline (1982). During an average of 12.5 person-years of follow-up, a total of 279 incident cases of age-related maculopathy with vision loss to 20/30 or worse were confirmed by medical record review. In multivariate analysis, as compared with nonusers of supplements, persons who used vitamin E supplements had a possible but nonsignificant 13% reduced risk of age-related maculopathy (relative risk = 0.87, 95 percent confidence interval (CI) 0.53-1.43), while users of multivitamins had a possible but nonsignificant 10% reduced risk (relative risk = 0.90, 95% CI 0.68-1.19). Users of vitamin C supplements had a relative risk of 1.03 (95% CI 0.71-1.50). These observational data suggest that among persons who self-select for supplemental use of antioxidant vitamin C or E or multivitamins, large reductions in the risk of age-related maculopathy are unlikely. Randomized trial data are accumulating to enable reliable detection of the existence of more plausible small-to-moderate benefits of these agents alone and in combination on age-related maculopathy.  (+info)

Demonstration of rapid onset vascular endothelial dysfunction after hyperhomocysteinemia: an effect reversible with vitamin C therapy. (6/4830)

BACKGROUND: Hyperhomocysteinemia is a major and independent risk factor for vascular disease. The mechanisms by which homocysteine promotes atherosclerosis are not well understood. We hypothesized that elevated homocysteine concentrations are associated with rapid onset endothelial dysfunction, which is mediated through oxidant stress mechanisms and can be inhibited by the antioxidant vitamin C. METHODS AND RESULTS: We studied 17 healthy volunteers (10 male and 7 female) aged 33 (range 21 to 59) years. Brachial artery diameter responses to hyperemic flow (endothelium dependent), and glyceryltrinitrate (GTN, endothelium independent) were measured with high resolution ultrasound at 0 hours (fasting), 2 hours, and 4 hours after (1) oral methionine (L-methionine 100 mg/kg), (2) oral methionine preceded by vitamin C (1g/day, for 1 week), and (3) placebo, on separate days and in random order. Plasma homocysteine increased (0 hours, 12.8+/-1.4; 2 hours, 25.4+/-2.5; and 4 hours, 31. 2+/-3.1 micromol/l, P<0.001), and flow-mediated dilatation fell (0 hours, 4.3+/-0.7; 2 hours, 1.1+/-0.9; and 4 hours, -0.7+/-0.8%) after oral L-methionine. There was an inverse linear relationship between homocysteine concentration and flow-mediated dilatation (P<0. 001). Pretreatment with vitamin C did not affect the rise in homocysteine concentrations after methionine (0 hours, 13.6+/-1.6; 2 hours, 28.3+/-2.9; and 4 hours, 33.8+/-3.7 micromol/l, P=0.27), but did ameliorate the reduction in flow-mediated dilatation (0 hours, 4. 0+/-1.0; 2 hours, 3.5+/-1.2 and 4 hours, 2.8+/-0.7%, P=0.02). GTN-induced endothelium independent brachial artery dilatation was not affected after methionine or methionine preceded by vitamin C. CONCLUSIONS: We conclude that an elevation in homocysteine concentration is associated with an acute impairment of vascular endothelial function that can be prevented by pretreatment with vitamin C in healthy subjects. Our results support the hypothesis that the adverse effects of homocysteine on vascular endothelial cells are mediated through oxidative stress mechanisms.  (+info)

L-Ascorbic acid potentiates nitric oxide synthesis in endothelial cells. (7/4830)

Ascorbic acid has been shown to enhance impaired endothelium-dependent vasodilation in patients with atherosclerosis by a mechanism that is thought to involve protection of nitric oxide (NO) from inactivation by free oxygen radicals. The present study in human endothelial cells from umbilical veins and coronary arteries investigates whether L-ascorbic acid additionally affects cellular NO synthesis. Endothelial cells were incubated for 24 h with 0.1-100 microM ascorbic acid and were subsequently stimulated for 15 min with ionomycin (2 microM) or thrombin (1 unit/ml) in the absence of extracellular ascorbate. Ascorbate pretreatment led to a 3-fold increase of the cellular production of NO measured as the formation of its co-product citrulline and as the accumulation of its effector molecule cGMP. The effect was saturated at 100 microM and followed a similar kinetics as seen for the uptake of ascorbate into the cells. The investigation of the precursor molecule L-gulonolactone and of different ascorbic acid derivatives suggests that the enediol structure of ascorbate is essential for its effect on NO synthesis. Ascorbic acid did not induce the expression of the NO synthase (NOS) protein nor enhance the uptake of the NOS substrate L-arginine into endothelial cells. The ascorbic acid effect was minimal when the citrulline formation was measured in cell lysates from ascorbate-pretreated cells in the presence of known cofactors for NOS activity. However, when the cofactor tetrahydrobiopterin was omitted from the assay, a similar potentiating effect of ascorbate pretreatment as seen in intact cells was demonstrated, suggesting that ascorbic acid may either enhance the availability of tetrahydrobiopterin or increase its affinity for the endothelial NOS. Our data suggest that intracellular ascorbic acid enhances NO synthesis in endothelial cells and that this may explain, in part, the beneficial vascular effects of ascorbic acid.  (+info)

Cytotoxic effect of paraquat on rat C6 glioma cells: evidence for the possibility of non-oxidative damage to the cells. (8/4830)

Although paraquat has been shown to cause oxidative damage to neuronal cells, little is known about its effect on glial cells. Thus the effect of paraquat on glial cells was examined using rat C6 glioma cells as a model system. Paraquat reduced cell viability in a concentration- and time-dependent manner, and this toxic effect was not significantly attenuated by various kinds of antioxidants. Furthermore, paraquat failed to increase 8-hydroxy-deoxyguanosine formation in the cells. These results indicate that paraquat can be toxic to glial cells and suggest that this cytotoxic effect may not be associated with the oxidative damage to the cells.  (+info)

Ascorbic acid deficiency can occur due to several reasons, including:

1. Poor diet: A diet that is lacking in vitamin C-rich foods such as citrus fruits, leafy greens, and bell peppers can lead to a deficiency.
2. Inability to absorb vitamin C: Certain medical conditions such as celiac disease, Crohn's disease, and ulcerative colitis can impair the body's ability to absorb vitamin C from food.
3. Increased demand: Vitamin C is essential for wound healing, and during pregnancy and lactation, the body requires more vitamin C to support fetal growth and development.
4. Long-term use of antacids or proton pump inhibitors: These medications can reduce the absorption of vitamin C.

The symptoms of ascorbic acid deficiency can vary depending on the severity of the deficiency and may include:

1. Fatigue and weakness
2. Mood changes such as irritability, anxiety, or depression
3. Difficulty healing from wounds or infections
4. Swelling or bleeding in the gums
5. Joint pain and stiffness
6. Frequent infections such as the common cold or flu
7. Poor digestion and diarrhea

If left untreated, ascorbic acid deficiency can lead to more severe conditions such as scurvy, which can cause:

1. Bleeding gums and teeth
2. Joint pain and swelling
3. Weakened immune system
4. Poor wound healing
5. Fatigue and weakness

Treatment for ascorbic acid deficiency typically involves supplementing with vitamin C, either orally or intravenously, and addressing any underlying causes of the deficiency. In severe cases, hospitalization may be necessary to monitor and treat any complications.

Prevention is key, so it's important to maintain a balanced diet that includes foods rich in vitamin C, such as citrus fruits, leafy greens, and berries. Additionally, avoiding smoking and limiting alcohol consumption can also help prevent ascorbic acid deficiency.

In conclusion, ascorbic acid deficiency is a common nutrient deficiency that can have significant impacts on overall health and well-being. Recognizing the causes, symptoms, and treatment options is essential for proper management and prevention of this condition.

There are several ways to prevent and treat scurvy, including:

* Eating foods rich in vitamin C, such as citrus fruits, leafy greens, and bell peppers.
* Taking vitamin C supplements.
* Increasing the intake of other nutrients that help the body absorb vitamin C, such as calcium and potassium.
* Avoiding foods and drinks that are high in oxalic acid, which can interfere with the absorption of vitamin C.

The discovery of scurvy and its treatment have had a significant impact on the history of medicine and nutrition. It led to the discovery of other essential nutrients and the development of modern nutrition science.

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Common oxidizing agents are: ascorbic acid (Ascorbic acid converts into its oxidizing form, dehydroascorbic acid (DHAA) during ... "Ascorbic Acid as an Oxidant in Wheat Flour Dough. I. Conversion to Dehydroascorbic Acid" (PDF). Cereal Chemistry. 57 (2): 85-87 ... "Ascorbic acid". Sustain. Retrieved 8 July 2014. Manley, Duncan (2000). Technology of Biscuits, Crackers, and Cookies (3rd ed ... Elkassabany, M.; Hoseney, R.C. (1980). "Ascorbic Acid as an Oxidant in Wheat Flour Dough. II. Rheological Effects" (PDF). ...
Johnston, C.S. (1996). "Chapter 10) The Antihistamine Action of Ascorbic Acid". Ascorbic Acid; Biochemistry and Biomedical Cell ...
A side product with particular modification is 5-Keto-D-gluconic acid. A shorter biotechnological synthesis of ascorbic acid ... L-ascorbic acid biosynthesis. In: Vitamins and Hormones 2001; 61:241-66. doi:10.1016/s0083-6729(01)61008-2 PMID 11153268. ... The Reichstein process in chemistry is a combined chemical and microbial method for the production of ascorbic acid from D- ... 2006): The use of microorganisms in L-ascorbic acid production. In: J Biotechnol. 124(1); 196-205; PMID 16516325; doi:10.1016/j ...
"Ascorbic acid/Phenylephrine/Paracetamol". NHS Choices. National Health Service. Archived from the original on 26 March 2014. ... Sometimes a third active ingredient, such as ascorbic acid, caffeine, chlorpheniramine maleate, or guaifenesin is added to this ... p-Aminophenol is then converted in the brain by fatty acid amide hydrolase into AM404, a compound that may be partially ... This occurs only when the concentration of arachidonic acid and peroxides is low. Under these conditions, COX-2 is the ...
Ascorbic acid is present at high levels in all parts of plants and can reach concentrations of 20 millimolar in chloroplasts. ... Ascorbic acid is a redox catalyst which can reduce, and thereby neutralize, reactive oxygen species such as hydrogen peroxide. ... Ascorbic acid is required for the conversion of the procollagen to collagen by oxidizing proline residues to hydroxyproline. In ... As one of the enzymes needed to make ascorbic acid has been lost by mutation during primate evolution, humans must obtain it ...
"Vitamin C (Ascorbic acid)". MedlinePlus. U.S. National Library of Medicine. 2010. Retrieved 23 March 2018. Collins MD, Mao GE ( ... The study found a significant effect on heart health in a low-salt diet, and a small effect due to omega-3 and folic acid ... as well as 400μg of folic acid during the first trimester (first 12 weeks of pregnancy). Some women may need to take iron, ...
Food portal Vitamin C Intravenous ascorbic acid Megavitamin therapy Orthomolecular medicine Uric acid Institute of Medicine ( ... "Vitamin C (Ascorbic Acid)". University of Maryland Medical Center. April 2002. Archived from the original on 2005-12-31. ... Vitamin C megadosage is a term describing the consumption or injection of vitamin C (ascorbic acid) in doses well beyond the ... Based on that study, the American Burn Association (ABA) considers high-dose ascorbic acid an option to be considered for ...
Histamine and ascorbic acid in human blood. J. Nutr. 110:662-668. Biologic Markers in Reproductive Toxicology (1989) "Cell ... Clemetson CA (1976). "Ascorbic acid and diabetes mellitus". Medical Hypotheses. 2 (5): 193-4. doi:10.1016/0306-9877(76)90037-2 ... Clemetson CA (1 April 1980). "Histamine and ascorbic acid in human blood". Journal of Nutrition. 110 (4): 662-8. doi:10.1093/jn ... doi:10.1016/s0010-7824(71)80004-5. Saroja N, Mallikarjuneswara VR, Clemetson CA (1971). "Effect of estrogens on ascorbic acid ...
Ascorbic acid and melanogenesis. Br J Dermatol. 1977 Aug;97(2):201-4. 8. Reddi YV, Sastry PB, Ramadas G. The effects of excess ...
Weis, W. (1975-09-30). "Ascorbic acid and biological systems. Ascorbic acid and electron transport". Annals of the New York ...
Antioxidants: Three vitamins, ascorbic acid; α-tocopherol; and β-carotene, are well recognized for their antioxidant activities ... Mullan B. A.; Young I. S.; Fee H.; McCance D. R. (2002). "Ascorbic acid reduces blood pressure and arterial stiffness in type 2 ... Folic acid: Low plasma concentrations of folic acid were found to be associated with high plasma homocysteine concentrations. ... van Etten et al., found that a single dose of folic acid might help in reducing the risk of vascular complications and ...
Nelson PJ, Pruitt RE, Henderson LL, Jenness R, Henderson LM (Jan 1981). "Effect of ascorbic acid deficiency on the in vivo ... Rebouche CJ (Dec 1991). "Ascorbic acid and carnitine biosynthesis". The American Journal of Clinical Nutrition. 54 (6 Suppl): ... Rebouche CJ (Dec 1991). "Ascorbic acid and carnitine biosynthesis". The American Journal of Clinical Nutrition. 54 (6 Suppl): ... Sesti C, Simkhovich BZ, Kalvinsh I, Kloner RA (Mar 2006). "Mildronate, a novel fatty acid oxidation inhibitor and antianginal ...
They are adducts of ascorbic acid. The plant also contains 2-isoprenyl-N,N-dimethyltryptamine, another tryptamine alkaloid, as ...
Manwaring WH (1945). "Ascorbic Acid vs. the Common Cold". Cal West Med. 62 (6): 309-10. PMC 1781017. PMID 18747053. Hemilä H ( ...
... is a sugar acid derived from threose. The l-isomer is a metabolite of ascorbic acid (vitamin C). One study ... S Englard and S Seifter (1986). "The Biochemical Functions of Ascorbic Acid". Annual Review of Nutrition. 6: 365-406. doi: ... Sugar acids, Alpha hydroxy acids, Triols, All stub articles, Organic compound stubs). ...
Ascorbic acid may also be added.[citation needed] In traditional Chinese medicine, the dried peel of the fruit is used in ... lower levels of citric acid. The clusters display different patterns of pomelo introgression, have different deduced historical ...
"Safety (MSDS) data for ascorbic acid". Oxford University. 2005-10-09. Archived from the original on 2007-02-09. Retrieved 2007- ... Erowid LSD (Acid) Vault : Fatalities / Deaths. Erowid.org. Retrieved on 2013-07-17. "Safety (MSDS) data for arsenic trioxide". ... "Safety (MSDS) data for acetylsalicylic acid". ox.ac.uk. Archived from the original on 2011-07-16. Boyd EM (May 1959). "The ... A.A. Babayan, A.V.Aleksandryan, "Toxicological characteristics of melamine cyanurate, melamine and cyanuric acid", Zhurnal ...
... s synthesize L-ascorbic acid only in the kidneys. Monotremes are conventionally treated as comprising a single order ... "Ascorbic acid biosynthesis in the mammalian kidney". ScienceScape.org. Archived from the original on 17 December 2014. ...
Gibson, Q. H. (1943). "The reduction of methaemoglobin by ascorbic acid". Biochemical Journal. 37 (5): 615-618. doi:10.1042/ ... Gibson, Q. H.; Wiseman, G. (1951). "Selective absorption of stereo-isomers of amino-acids from loops of the small intestine of ...
Mushran S.P., Mehrotra U.S. (1970). "Oxidation of ascorbic acid by osmium(VIII)". Canadian Journal of Chemistry. 48 (7): 1148- ... Osmium tetroxide is rapidly reduced to relatively inert compounds by e.g. ascorbic acid or polyunsaturated vegetable oils (such ... Vauquelin treated the powder alternately with alkali and acids and obtained a volatile new oxide, which he believed was of this ... Chemists who studied platinum dissolved it in aqua regia (a mixture of hydrochloric and nitric acids) to create soluble salts. ...
"Dietary phenolic acids and ascorbic acid: Influence on acid-catalyzed nitrosative chemistry in the presence and absence of ... "Fat transforms ascorbic acid from inhibiting to promoting acid-catalysed N-nitrosation". Gut. 56 (12): 1678-1684. doi:10.1136/ ... However, when 10% of the meal is fat, the effect is reversed, such that ascorbic acid then markedly increases nitrosamine ... Evidence now exists that ascorbic acid is a limiting factor in nitrosation reactions in people. Combet, E.; Paterson, S; Iijima ...
"Topical L-ascorbic acid: percutaneous absorption studies". Dermatol Surg. 27 (2): 137-42. doi:10.1046/j.1524-4725.2001.00264.x ...
Takanaga H, Mackenzie B, Hediger MA (February 2004). "Sodium-dependent ascorbic acid transporter family SLC23". Pflügers Archiv ... Na+-dependent ascorbic acid transporter (SLC23A1, SLC23A2, SLC23A3, SLC23A4) Na+/(Ca2+-K+) exchanger (SLC24A1, SLC24A2, SLC24A3 ... cationic amino acid transporter/glycoprotein-associated cationic amino acid transporters (SLC7A1, SLC7A2, SLC7A3, SLC7A4) ... Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (February 2004). "CATs and HATs: the SLC7 family of amino acid ...
Ascorbic acid is oxidised with molecular oxygen. Antibodies can act as enzymes, then named abzymes, if they are selected ...
Ohno, S; Ohno, Y; Suzuki, N; Soma, G; Inoue, M (2009). "High-dose vitamin C (ascorbic acid) therapy in the treatment of ... amino acids, ω-3 fatty acids, ω-6 fatty acids, medium-chain triglycerides, dietary fiber, short and long chain fatty acids, ... Klenner FR (1971). "Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in ... 1998). "Observations on the dose and administration of ascorbic acid when employed beyond the range of a vitamin in human ...
They found that beer staling is reduced by scavengers of the hydroxyl radical (•OH), such as mannitol and ascorbic acid. They ... brewers believe that α-acids give the beer a pleasant bitterness whereas β-acids are considered less pleasant. α-acids ... Isohumulone (an iso-alpha acid responsible for the bitter taste of hops) and its combinations with Ni, or Fe, also favor ... They used thiobarbituric acid (TBA) to estimate the staling substances after using an accelerated aging technique. ...
Kustin, Kenneth; Toppen, David L. (June 1973). "Reduction of vanadium(V) by L-ascorbic acid". Inorganic Chemistry. 12 (6): 1404 ... perchlorate can be made by dissolving vanadium pentoxide in perchloric acid. The reaction of vanadium pentoxide and dichlorine ...
Pantothenic acid) - Vitamin B6 (Pyrodoxine) - Vitamin B12 (Cyanocobalamin) - Vitamin C (Ascorbic acid) - Vitamin D (Calciferol ... Common food acids include vinegar, citric acid, tartaric acid, malic acid, folic acid, fumaric acid, and lactic acid. Acidity ... Citranaxanthin - color Citric acid - food acid Citric acid esters of mono- and diglycerides of fatty acids - emulsifier Citrus ... Phosphated distarch phosphate - thickener, vegetable gum Phosphoric acid - food acid Phytic acid - preservative Pigment Rubine ...
The kinetics of depolymerization of hyaluronic acid by l-ascorbic acid, and the inhibition of this reaction by anions of the ...
A11DA02 Sulbutiamine A11DA03 Benfotiamine A11GA01 Ascorbic acid (vitamin C) A11GB01 Ascorbic acid (vitamin C) and calcium ...
Wong, S.Z.H.; B. Ching; Y.R. Chng; W.P. Wong; S.F. Chew & Y.K. Ip (June 2013). "Ascorbic Acid Biosynthesis and Brackish Water ... by some euryhaline marine elasmobranchs and the ability of these elasmobranchs to increase the capacity of ascorbic acid ... "Molecular Phylogeny of Asian Freshwater and Marine Stingrays Based on the DNA Nucleotide and Deduced Amino Acid Sequences of ...
When fresh, the young leaves contain up to 585 mg of ascorbic acid (vitamin C) per 100 grams (3.5 oz) and the fruits contain ... Milton, K.; Jenness, R. (1987). "Ascorbic acid content of neotropical plant parts available to wild monkeys and bats". ... the enzyme required to convert glucose to ascorbic acid. The fruits of F. yoponensis contain more vitamin C than any other ...
Additionally, the study yielded several bioactive and beneficial components such as "phenol, flavonoid, ascorbic acid, B- ... due to the fact that acetonitrile is a common ingredient in supplements that are used to break down saturated fatty acids and ...
20 mg ascorbic acid, 3660 μg β-Carotene, 75 mg phosphorus, and 0.59 mg riboflavin per 100 g fresh weight. The leaves also ...
... it was given the formal chemical name of L-ascorbic acid. In some experiments they used paprika as the source for their vitamin ... His research involved isolating an organic acid, which he then called "hexuronic acid", from adrenal gland tissue. He accepted ... He is credited with first isolating vitamin C and discovering the components and reactions of the citric acid cycle. He was ... There Szent-Györgyi and his research fellow Joseph Svirbely found that "hexuronic acid" was actually the thus far unidentified ...
Other additives may be pectin to prepare jellies, ascorbic acid to improve shelf life and other ingredients that will dissolve ... Long dwell times in juicers made from aluminium when preparing acid juices is not recommended. Increasing the steam flow-rate ...
Ascorbic acid is an effective antiseptic used to heal mouth sores and reduce inflammation. These results were determined by ... Diets with key nutrients such as zinc, polyphosphates, and ascorbic acid, can aid in the prevention of dental disease and the ... Ascorbic acid, also known as vitamin C, is a useful ingredient for cats whose mouth and gums are already diseased. It is ...
Johnston, C. S.; Martin, L. J.; Cai, X. (1992-04-01). "Antihistamine effect of supplemental ascorbic acid and neutrophil ...
2009). "Simultaneous electrochemical determination of uric acid, dopamine, and ascorbic acid at single-walled carbon nanohorn ... and ascorbic acid in urine samples. Special designed SWNHs nanocomposites have versatile biosensing applications. One example ... electrode displayed excellent electrochemical catalytic activities and could be used to simultaneously determine uric acid, ...
Lentils, dried vegetables and powdered milk were on the menu with the addition of cod liver oil along with ascorbic acid and ...
Dichlorophenol-indophenol (DCPIP), a form of indophenol, is often used to determine the presence of vitamin C (ascorbic acid). ... Hughes, David Emlyn (1983). "Titrimetric Determination of Ascorbic Acid with 2,6-Dichlorophenol Indophenol in Commercial Liquid ... Sabnis, R. W. (2007). Handbook of Acid-Base Indicators. CRC Press. p. 196. ISBN 978-0-8493-8219-2. Patton, Charles J.; Crouch, ...
... organic acids (ascorbic acid, malic acid), chewing gum, parasympathomimetic drugs (choline esters, e.g. pilocarpine ... resulting in acid production and development of dental caries. Acid erosion. Saliva acts as a buffer and helps to prevent ... Stimulated salivary flow rate is calculated using a stimulant such as 10% citric acid dropped onto the tongue, and collection ...
It was made by citric and ascorbic acid from natural fruit extracts. This type of "chhana" cannot be worked on to compact into ... This is because of a documented technological issue - lactic acid (extracted from whey) used to curdle milk now was introduced ... to India in the late 18th century by Dutch and Portuguese colonists (along with acetic acid). It is this method that creates ...
The fruit contains citric acid, tartaric acid, malic acid and ascorbic acid, hydroxycitric acid, and flavonoids. Ripe asam ... "Capillary zone electrophoresis for separation and analysis of hydroxycitric acid and hydroxycitric acid lactone: Application to ...
... the anion of ascorbic acid). Mineral ascorbates are powders manufactured by reacting ascorbic acid with mineral carbonates in ... Mineral ascorbates are a group of salts of ascorbic acid (vitamin C). They are composed of a mineral cation bonded to ascorbate ... Ascorbate salts may be better tolerated by the human body than the corresponding weakly acidic ascorbic acid. Ascorbates are ...
... ascorbic acid, and extract from coffea fruit harvested in Indonesia; its flavors typically are identified by the name of an ...
... (also known as dikegulac) is a precursor used in commercial ascorbic acid production. In agriculture, its ...
Results of the ethanolic extract exhibited low antioxidant activity when compared with standard ascorbic acid and less toxic ...
... ascorbic acid, and grapefruit extract. Green cleaning Vegan soap "How do detergents and soaps work?". Explain that Stuff. ... gluconic acid, citric acid, and polyelectrolytes. Ultimately, effective detergent formulations using citric acid and ... Today, formulations with zeolites, polycarboxylates, citric acid, and sodium bicarbonate are among the most effective and ... manufacturers explored the use of other compounds as a potential substitute for phosphates such as nitrile-tri-acetic acid (NTA ...
... ascorbic acid, emulsifier: modified corn starch, coconut oil, vitamin B1. "Isostar". "IsostarUK.com". Archived from the ... Water, carbohydrates (sucrose, glucose syrup dehydrated DE47, maltodextrin DE19), acidity regulator: citric acid, sodium ...
The ingredients in most Airborne products include: Vitamin A as retinyl palmitate Vitamin C (ascorbic acid) Vitamin E (as delta ... Amino acids: glutamine (as L-glutamine) and lysine (as L-lysine HCl) Other ingredients: maltodextrin, sorbitol, citric acid, ... Airborne is an American brand of dietary supplement containing herbal extracts, amino acids, antioxidants, electrolytes, ... acetate) Riboflavin (vitamin B2) Magnesium (as oxide and sulfate) Zinc (as sulfate) Selenium (as amino acid chelate) Manganese ...
... ascorbic acid oxidase, ascorbate oxidase, ascorbic oxidase, ascorbate dehydrogenase, L-ascorbic acid oxidase, AAO, L-ascorbate: ...
This anion is then reduced by, for example, ascorbic acid or SnCl2, to form the blue coloured β-keggin ion, PMo 12O7− 40. The ... molybdenum sulfide with nitric acid to form molybdic acid, which is then mixed with tin filings and a little muriatic acid (HCl ... Dissolving molybdate salts in strong acid produces "molybdic acid", MoO3·2H2O. In between these extremes of pH, polymeric ions ... A sample containing the phosphate is mixed with an acid solution of MoVI, for example ammonium molybdate, to produce PMo 12O3− ...
... and ascorbic acid. List of defunct consumer brands "Beep is back". Farmer's Dairy. Retrieved 2012-09-13. End of the road for ... citric acid, orange pulp, natural flavours, sodium citrate, canola oil, modified corn starch, sodium benzoate, caramel colour, ...
Under specific conditions and in the presence of other chemicals benzoic acid (a preservative) and ascorbic acid (Vitamin C) ... The existence and mode of formation of insolinic acid prove that to the series of monobasic aromatic acids, Cn2Hn2-8O4, the ... t-muconic acid, S-phenylmercapturic acid and benzene as biomarkers of low benzene exposure". Chemico-Biological Interactions. ... Benzoic acid and its salts undergo decarboxylation to benzene. The reaction of the diazonium compound derived from aniline with ...
... reported that the adrenal ascorbic acid-depleting properties of corticotropin are destroyed by treatment with ascorbic acid at ... when assayed by the adrenal ascorbic acid-depletion method of Sayers, Sayers and Woodbury3. ... reported that the adrenal ascorbic acid-depleting properties of corticotropin are destroyed by treatment with ascorbic acid at ... when assayed by the adrenal ascorbic acid-depletion method of Sayers, Sayers and Woodbury3. ...
ASCORBIC ACID (UNII: PQ6CK8PD0R) (ASCORBIC ACID - UNII:PQ6CK8PD0R) ASCORBIC ACID. 500 mg in 1 mL. ... The chemical name of Ascorbic Acid is L-ascorbic acid. The molecular formula is C 6H 8O 6. It has the following structural ... Ascorbic acid (vitamin C) is present in human milk after maternal oral intake. Maternal oral intake of ascorbic acid (vitamin C ... Ascorbic acid (vitamin C) is present in human milk after maternal oral intake. Maternal oral intake of ascorbic acid (vitamin C ...
Testing Status of L-Ascorbic acid 10357-S. Testing Status of L-Ascorbic acid 10357-S. CASRN: 50-81-7. Formula: C6-H8-O6. ... Carcinogenesis Bioassay of L-Ascorbic Acid (Vitamin C) (CASRN 50-81-7) in F344/N Rats and B6C3F1 Mice (Feed Study) ...
"ascorbic acid"[MeSH Terms] OR ("ascorbic"[All Fields] AND "acid"[All Fields]) OR "ascorbic acid"[All Fields]. Search. ...
Ascorbic Acid (Vitamin C): learn about side effects, dosage, special precautions, and more on MedlinePlus ... Ascorbic acid (vitamin C) is used as a dietary supplement when the amount of ascorbic acid in the diet is not enough. People ... Before taking ascorbic acid,. *tell your doctor and pharmacist if you are allergic to ascorbic acid, any other medications, or ... Ascorbic acid is available without a prescription, but your doctor may prescribe ascorbic acid to treat certain conditions. ...
Ascorbic Acid Function and Metabolism. Grant Number: 5R01DK050435-17. PI Name: May. Project Title: Ascorbic Acid Function and ... This leads to the main hypothesis of this proposal that ascorbic acid helps to maintain endothelial barrier function in vivo ... Abstract: DESCRIPTION (provided by applicant): Plasma and cell levels of vitamin C, or ascorbic acid, are decreased about 50% ... Results from the previous project period showed that ascorbic acid tightens the endothelial barrier to passage of large ...
L. ascorbic acid. Spike Walker Affiliation. Microworld Services. Penkridge, United Kingdom. Technique. Polarized Light. ...
Ascorbic Acid (Vitamin C) Ascorbic acid (vitamin C) is used as a dietary supplement when the amount of ascorbic acid in the ... that increase acid in the urine, such as ascorbic acid or cranberry juice, may be recommended. These medicines ... ... ClinicalTrials.gov: Ascorbic Acid (National Institutes of Health) Vitamin C/Clinical Trials ... Vitamin C ... National ... does it do? Vitamin C, also known as ascorbic acid, is a water-soluble nutrient found in some ... dietary supplements is ...
Learn about drug interactions between ascorbic acid oral and butalbital-acetaminophen-caffeine oral and use the RxList drug ... Drug interactions with ascorbic acid oral and butalbital-acetaminophen-caffeine oral. home drug interactions checker , ascorbic ... ascorbic acid oral brand names and other generic formulations include:. Acerola C Oral, Acerola C-500 Oral, Acerola Complex ... All generic drug interactions for ascorbic acid oral (lists will include brand and generic names): ...
Ascorbic acid. Pauling L. Pauling L. Lancet. 1979 Mar 17;1(8116):615. Lancet. 1979. PMID: 85208 No abstract available. ... Ascorbic acid in the treatment and prevention of skin diseases]. Romanenko GF, Fomina LP, Mozherenkov VP. Romanenko GF, et al. ... Ascorbic acid in the treatment of eye diseases]. Mozherenkov VP, Agafonov BV. Mozherenkov VP, et al. Oftalmol Zh. 1980;35(2): ...
... ascorbic acid including side effects, age restrictions, food interactions, whether the medicine is available at a government ... Medicines that contain cranberry + colloidal anhydrous silica + ascorbic acid *Cranberry 35 000 mg Plus (Blooms) ... Active ingredient: cranberry + colloidal anhydrous silica + ascorbic acid. The medicines below all contain the following active ... ascorbic acid. You can select a medicine from this list to find out more - including side effects, age restrictions, food ...
... and am wondering if the addition of ascorbic acid will help to make them lighter. Does anyone routinely use ascorbic acid in ... Ascorbic Acid Chemistry. I am a chemist and I, too, was puzzled by baking sites referring to ascorbic acid as an oxidant. It ... by the yeasts in the place of artificially added ascorbic acid. So no, there is no reason to add ascorbic acid to starter yeast ... by the yeasts in the place of artificially added ascorbic acid. So no, there is no reason to add ascorbic acid to starter yeast ...
ascorbic acid; l-ascorbic acid; vitamin C .... Source: ChemIDplus. Deposit Date: 2012-03-21. Available Date: 2012-03-21. Modify ...
Vitron-CWhat is the most important information I should know about ascorbic acid and carbonyl iron?Keep this product out of ... Top of the pageascorbic acid and carbonyl ironPronunciation: as KORE bik AS id and KAR boe nilBrand: Fe C, Icar-C, ... What is ascorbic acid and carbonyl iron?. Ascorbic acid (vitamin C) is found in citrus fruit, tomatoes, potatoes, and leafy ... What other drugs will affect ascorbic acid and carbonyl iron?. Other drugs may interact with ascorbic acid and carbonyl iron, ...
... the high ascorbic acid doses in the treatment of hepatitis epidemica. After Lehnartz, the biological function of ascorbic acid ... the children kept on intravenous ascorbic acid, 10 g daily, who excreted a further 200-300 mg daily ascorbic acid. This was ... acid simultaneously. These investigations speak for the fact that the ascorbic acid is able to eliminate liver dysfunctions. ... Ascorbic acid is protective during experimental liver damage (Hirata, Beyer, Milhorat et al). Hirata obtained an acute liver ...
Basically, the author states that ascorbic acid is not vitamin C. Here are some snippets. From... ... Ascorbic acid is not a living complex. It is a copy of a part of a living complex known as vitamin C. Ascorbic acid is a ... It seems that ascorbic acid has antioxidant properties on its own but taking ascorbic acid is not the same as taking vitamin c ... It seems that ascorbic acid has antioxidant properties on its own but taking ascorbic acid is not the same as taking vitamin c ...
Leucocytic level of ascorbic acid was not as good an index of ascorbic acid status as the platelet level. ... Status of Ascorbic Acid in Iron Deficiency Anaemia and Thalassaemia Subject Area: Hematology , Oncology ... The status of ascorbic acid was studied at the levels of platelet and leucocyte in 32 cases of iron deficiency anaemia, 35 ... Bharati Chatterjea, Arati Maitra, D.K. Banerjee, A.K. Basu; Status of Ascorbic Acid in Iron Deficiency Anaemia and Thalassaemia ...
ascorbic, acid, usp, powder, powders, vitamin, c, antioxidants, antioxidant, anti-oxidants, anti-oxidant, preservative, ... Ascorbic acid 02/29/2016 By Jane OBrien Great service, as always efficient, almost bought the wrong product, Doug helped ... Ascorbic Acid is an anti-oxidant used as a partial substitute for sulfur dioxide, or used to prevent oxidation, which creates a ... Ascorbic Acid, like Copper Sulfate, is often used to treat hydrogen sulfide (H2S) or mercaptans, which presents as a rotten ...
China Ascorbic Acid, Vitamin B, Lutein, Paracetamol, Sodium saccharin Supplier - KANEGRADE(QINGDAO) INGREDIENTS CO., LTD ... Main Products: Ascorbic Acid, Vitamin B, Lutein, Paracetamol, Sodium saccharin Company Type: Trade & Service Established Year: ...
Get up-to-date information on Ascorbic Acid side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about ... Ascorbic Acid 25 Mg Oral Tablet, Chewable*Ascorbic Acid 250 Mg Oral Gum*Ascorbic Acid 250 Mg Oral Tablet*Ascorbic Acid 250 Mg ... Ascorbic Acid 500 Mg Oral Tablet*Ascorbic Acid 500 Mg Oral Tablet, Chewable*Ascorbic Acid 500 Mg/5 Ml Oral Liquid*Ascorbic Acid ... Ascorbic Acid 100 Mg/ml Oral Liquid*Ascorbic Acid 1000 Mg Oral Tablet*Ascorbic Acid 1000 Mg Oral Tablet, Chewable*Ascorbic Acid ...
When you rub pieces of apple or a cut artichoke with a lemon, it is the ascorbic ... Ascorbic Acid is a chemists name for plain, old-fashioned Vitamin C. In cooking, aside from its obvious nutritional advantages ... Technically, there are actually two forms of ascorbic acid: L-ascorbic acid and L-dehydroascorbic acid. L-ascorbic acid becomes ... Ascorbic Acid Mixtures. Special anti-darkening preparations made of ascorbic acid and citric acid mixed with sugar are ...
Exogenous ethylene (10 ppm) neither affected reduced ascorbic acid levels in normal and rin fruits, nor the total ascorbic acid ... Maintenance of initial levels of total ascorbic acid was noted in ethylene treated rin fruits. Similar total ascorbic acid ... No change in reduced ascorbic acid levels from mature green to yellow rin fruits was observed when detached from the plant. ... Apparently, a reduction mechanism from dehydro to reduced ascorbic acid is active in normal tomatoes but inactive in detached ...
Effect of Seasonal Temperatures and Ascorbic Acid Supplementation on Performance of Broiler Chickens Maintained in Closed and ... Ascorbic acid supplementation at 200-300 ppm was associated with a reduction in rectal temperatures during the hot season. Open ... The Effects of Ascorbic Acid and Seasonal Temperatures on Meat Quality Characteristics of Broiler Chickens Maintained in Open- ... The efficacy of ascorbic acid in drinking water on performance of broiler chickens under closed and open-sided houses during ...
... and 60 mg doses of ascorbic acid/100g body weight/day were given for 105 days. Neither of the ascorbic acid doses given induced ... In the second set of experiments, ascorbic acid was supplemented in hypercalciuric (induced by calcium carbonate feeding) and ... thereby confirming our previous findings that ascorbic acid in the doses used by clinicians does not cause urolith formation. ... Two sets of animal experiments using guinea pigs were planned to evaluate the effect of ascorbic acid supplementation on the ...
  • Some forms of ascorbic acid contain sodium and should be avoided if you are on a sodium- or salt-restricted diet. (medlineplus.gov)
  • Technically, there are actually two forms of ascorbic acid: L-ascorbic acid and L-dehydroascorbic acid. (cooksinfo.com)
  • Diabetics, patients prone to recurrent renal calculi, those undergoing stool occult blood tests and those on sodium restricted diets or anticoagulant therapy should not take excessive doses of ascorbic acid over an extended period of time. (nih.gov)
  • Do not stop using ascorbic acid suddenly after long-term use at high doses, or you could have "conditional" vitamin C deficiency. (drugs.com)
  • Ascorbic Acid is the name for an active form of Vitamin C, a water-soluble vitamin that has been the subject of a great deal of controversy, especially with regard to dosage and disease prevention. (healthy-eating-support.org)
  • Ascorbic acid is also used to prevent and treat scurvy (a disease that causes fatigue, gum swelling, joint pain, and poor wound healing from a lack of vitamin C in the body). (medlineplus.gov)
  • Ascorbic acid deficiency results in scurvy. (nih.gov)
  • Ascorbic acid is recommended for the prevention and treatment of scurvy. (nih.gov)
  • People most at risk for ascorbic acid deficiency are those with a limited variety of food in their diet, or who have intestinal malabsorption problems from cancer or kidney disease. (medlineplus.gov)
  • This hypothesis and mechanism will be tested in endothelial cells cultured at hyperglycemic glucose concentrations and extended to novel mouse models of ascorbic acid deficiency or repletion in the context of streptozotocin-induced diabetes. (nih.gov)
  • The status of ascorbic acid was studied at the levels of platelet and leucocyte in 32 cases of iron deficiency anaemia, 35 cases of thalassaemia and 18 normal subjects. (karger.com)
  • It was found that in iron deficiency anaemia, platelet ascorbic acid was significantly higher than normal values indicating tissue excess and came down sharply after treatment with iron. (karger.com)
  • In thalassaemia, associated presumably with iron overload, ascorbic acid status of platelets was definitely lower than normal indicating tissue deficiency. (karger.com)
  • Administration of ascorbic acid completely reverses the symptoms of ascorbic acid deficiency. (nih.gov)
  • Its parenteral administration is desirable for patients with an acute deficiency or for those whose absorption of orally ingested ascorbic acid is uncertain. (nih.gov)
  • Ascorbic acid is used to treat and prevent vitamin C deficiency . (drugs.com)
  • Ascorbic acid comes in extended-release (long-acting) capsules and tablets, lozenges, chewable tablets, chewable gels (gummies), and liquid drops to be given by mouth. (medlineplus.gov)
  • Ascorbic Acid (vitamin C) is a water-soluble vitamin. (nih.gov)
  • Buffered Ascorbic Acid Capsules - 90 count has been added to your list successfully. (drhyman.com)
  • ASCOR vials contain 25, 000 mg of ascorbic acid and the largest recommended single dose is 200 mg. (nih.gov)
  • Cigarette smoking may decrease the effectiveness of ascorbic acid and you may need to take a larger dose. (medlineplus.gov)
  • Talk to your doctor or pharmacist about your dose of ascorbic acid if you use tobacco products. (medlineplus.gov)
  • In some cases, you may not be able to use ascorbic acid and carbonyl iron, or you may need a dose adjustment or special precautions. (uofmhealth.org)
  • In order to achieve a therapeutic dose, Dr. Pauling himself took a powdered form of ascorbic acid for much of his life. (healthy-eating-support.org)
  • Our bodies use Ascorbic Acid to make collagen. (cooksinfo.com)
  • In humans, an exogenous source of ascorbic acid is required for collagen formulation and tissue repair. (nih.gov)
  • The second aim tests how ascorbic acid prevents endothelial barrier failure caused by high glucose concentrations, again with focus on a mechanism involving ascorbic acid prevention of uncoupling of nitric oxide synthase. (nih.gov)
  • Ascorbic acid in the treatment and prevention of skin diseases]. (nih.gov)
  • This decrease is due to oxidative stress from excess glucose and fatty acid metabolism. (nih.gov)
  • Heller-Krause rightly refers to the danger of overdosing only one amino acid, which can lead to correlation disturbances in protein metabolism. (seanet.com)
  • The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration. (nih.gov)
  • An amino acid derivative, synthesized from methionine and lysine, required in energy metabolism. (medscape.com)
  • Can promote excretion of excess fatty acids in patients with defects in fatty acid metabolism or specific organic acidopathies that cause acyl CoA esters to bioaccumulate. (medscape.com)
  • when assayed by the adrenal ascorbic acid-depletion method of Sayers, Sayers and Woodbury 3 . (nature.com)
  • Key to his aim is to assess whether diabetes-induced oxidative stress and subsequent endothelial dysfunction is worsened by depletion of ascorbic acid and reversed by its repletion. (nih.gov)
  • An abnormal increase in the acidity of the body's fluids, caused either by accumulation of acids or by depletion of bicarbonates. (cdc.gov)
  • Ascorbic Acid 500 mg, Disodium Edetate 0.25 mg, in Water for Injection q.s.. pH (range 5.5 to 7.0) adjusted with Sodium Bicarbonate and Sodium Hydroxide. (nih.gov)
  • Use of sodium citrate and citric acid (Bicitra), vitamin C and vitamin E, thioctic acid (ie, lipoic acid), and NAC are included here. (medscape.com)
  • Ascorbic acid supplements are available alone and in combination with other vitamins. (medlineplus.gov)
  • More recent results show that intracellular ascorbic acid also prevents the increase in endothelial barrier permeability caused by high glucose concentrations. (nih.gov)
  • The mechanism of this barrier protection is proposed to involve ascorbic acid scavenging of reactive oxygen species generated in response to high glucose concentrations, as well as ascorbic acid recycling of tetrahydrobiopterin to prevent uncoupling of endothelial nitric oxide synthase. (nih.gov)
  • Since many of the deleterious effects of high glucose concentrations are caused by activation of the Receptor for Advanced Glycation End-products (RAGE), the third aim will test the mechanism by which ascorbic acid prevents increased endothelial permeability due to RAGE ligands. (nih.gov)
  • Diabetics taking more than 500 mg of ascorbic acid daily may obtain false reading of the urinary glucose test. (nih.gov)
  • NAC is the N -acetyl derivative of the amino acid cysteine. (medscape.com)
  • Commercially prepared mixes of ascorbic and citric acid-seasonally available among canners' supplies in supermarkets. (cooksinfo.com)
  • Sometimes citric acid powder is sold in supermarkets, but it is less effective in controlling discoloration. (cooksinfo.com)
  • Citric acid mixtures may also be used. (medscape.com)
  • Add 200 mg of ascorbic acid (equivalent to 0.4 mL of ASCOR) to 7.5 mL of Sterile Water for Injection to produce an infusion solution having an approximate osmolarity of 290 mOsmol/L. In this specific example, addition of solute is NOT necessary because the solution is isotonic. (nih.gov)
  • Ascorbic Acid injection is a clear, colorless to slightly yellow sterile solution of Ascorbic Acid in Water for Injection, for intravenous, intramuscular or subcutaneous use. (nih.gov)
  • Animal reproduction studies have not been conducted with Ascorbic Acid Injection. (nih.gov)
  • It is also not known whether Ascorbic Acid Injection can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. (nih.gov)
  • Ascorbic Acid Injection should be given to a pregnant woman only if clearly needed. (nih.gov)
  • Caution should be exercised when Ascorbic Acid Injection is administered to a nursing woman. (nih.gov)
  • The recommended dietary allowance of vitamin C (ascorbic acid) increases with age. (drugs.com)
  • The fourth aim will extend the in vitro studies to novel mouse models in which ascorbic concentrations can be manipulated by dietary and genetic means to test effects of increased oxidative stress due to streptozotocin- induced diabetes. (nih.gov)
  • Regenerative Effect of L-Ascorbic Acid on the In vitro Grown Plants. (who.int)
  • Aim: In the present work, we have studied the effect of L ascorbic acid (LAA) on the regeneration of plants from different families cultured in vitro. (who.int)
  • tell your doctor and pharmacist if you are allergic to ascorbic acid, any other medications, or any of the ingredients in ascorbic acid products. (medlineplus.gov)
  • You should not use ascorbic acid if you have ever had an allergic reaction to a vitamin C supplement. (drugs.com)
  • Ascorbic acid and carbonyl iron may also be used for purposes not listed in this medication guide. (uofmhealth.org)
  • Most U.S. vitamin companies then buy the bulk ascorbic acid from this single facility. (cassiopaea.org)
  • Browse all the Ascorbic Acid in Rohtas on our website and place your bulk orders with us. (ryan-international.in)
  • As an eminent Ascorbic Acid Dealer and Wholesaler in Rohtas , we are available a phone call and click away to meet your bulk orders. (ryan-international.in)
  • Other drugs may interact with ascorbic acid and carbonyl iron, including prescription and over-the-counter medicines, vitamins, and herbal products. (uofmhealth.org)
  • Ascorbic acid is important for the skin and connective tissues, for normal chemical and hormonal production, and for the immune system. (uofmhealth.org)
  • What other drugs will affect ascorbic acid and carbonyl iron? (uofmhealth.org)
  • When isolated into artificial commercial forms, like ascorbic acid, these purified synthetics act as drugs in the body. (cassiopaea.org)
  • Ascorbic acid (vitamin C) is found in citrus fruit, tomatoes, potatoes, and leafy vegetables. (uofmhealth.org)
  • Ascorbic acid ( vitamin C ) occurs naturally in foods such as citrus fruit, tomatoes, potatoes, and leafy vegetables. (drugs.com)
  • Holzbauer and Walter 1 have recently reported that the adrenal ascorbic acid-depleting properties of corticotropin are destroyed by treatment with ascorbic acid at room temperature for 18-20 hr. (nature.com)
  • Ascorbic acid in the treatment of eye diseases]. (nih.gov)
  • Broilers in both houses were randomly subjected to four drinking water treatments (9 birds in each 6 replicates/treatment): 0, 100, 200 and 300 ppm ascorbic acid. (scialert.net)
  • In experiment 2, treatment with ascorbic acid had no effect as preservative and extending shelf life. (skemman.is)
  • The ascorbic acid you buy at the grocery store every few weeks, thinking you are buying Vitamin C, is just a chemical copy of naturally occurring ascorbic acid, which itself is still only a fraction of the actual Vitamin C. Real vitamin C is part of something living, and as such, can impart life. (cassiopaea.org)
  • Your pharmacist can provide more information about ascorbic acid and carbonyl iron. (uofmhealth.org)
  • Ascorbic acid is in a class of medications called antioxidants. (medlineplus.gov)
  • Unlike other derivatives of Vitamin C, the ethylated form is closer in molecular weight to the purest form of Ascorbic Acid, thus making it quicker and more effective in penetrating the skin's layers at a deeper level. (merchantmanila.com)
  • The concentration of ascorbic acid in the final, admixture solution for infusion is to be the range of 1 to 25 mg of ascorbic acid per mL. (nih.gov)
  • If you become pregnant while taking ascorbic acid, call your doctor. (medlineplus.gov)
  • This special form of ascorbic acid lessens possible gastric irritation in sensitive individuals. (drhyman.com)
  • Ascorbic acid (vitamin C) is used as a dietary supplement when the amount of ascorbic acid in the diet is not enough. (medlineplus.gov)
  • Abstract: DESCRIPTION (provided by applicant): Plasma and cell levels of vitamin C, or ascorbic acid, are decreased about 50% in persons with type II diabetes in sub-optimal glycemic control, despite presumably adequate dietary intakes. (nih.gov)
  • What is the most important information I should know about ascorbic acid and carbonyl iron? (uofmhealth.org)
  • Ascorbic acid and carbonyl iron is a combination vitamin/mineral supplement that helps your body better absorb iron from your diet. (uofmhealth.org)
  • What should I discuss with my healthcare provider before taking ascorbic acid and carbonyl iron? (uofmhealth.org)
  • How should I take ascorbic acid and carbonyl iron? (uofmhealth.org)
  • For best results, take ascorbic acid and carbonyl iron on an empty stomach at least 1 hour before or 2 hours after a meal. (uofmhealth.org)
  • Ascorbic acid and carbonyl iron may be taken with food if it upsets your stomach. (uofmhealth.org)
  • What should I avoid while taking ascorbic acid and carbonyl iron? (uofmhealth.org)
  • Ascorbic acid and carbonyl iron can make it harder for your body to absorb certain medicines you take by mouth. (uofmhealth.org)
  • Compared to the control group, ascorbic acid improved feed intake, body weight gain and feed conversion ratio by 6%, 9% and 3% (cool season) and 8%, 11% and 5% (hot season). (scialert.net)
  • Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. (nih.gov)
  • L-ascorbic acid becomes L-dehydroascorbic acid when it reacts with oxygen in the air. (cooksinfo.com)
  • This is not a complete list of Ascorbic Aciddrug interactions. (rxwiki.com)