Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.1.
An enzyme from the sulfuric ester hydrolase class that breaks down one of the products of the chondroitin lyase II reaction. EC 3.1.6.9.
An enzyme that catalyzes the hydrolysis of cerebroside 3-sulfate (sulfatide) to yield a cerebroside and inorganic sulfate. A marked deficiency of arylsulfatase A, which is considered the heat-labile component of cerebroside sulfatase, has been demonstrated in all forms of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.8.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
An autosomal recessive metabolic disease caused by a deficiency of CEREBROSIDE-SULFATASE leading to intralysosomal accumulation of cerebroside sulfate (SULFOGLYCOSPHINGOLIPIDS) in the nervous system and other organs. Pathological features include diffuse demyelination, and metachromatically-staining granules in many cell types such as the GLIAL CELLS. There are several allelic and nonallelic forms with a variety of neurological symptoms.
An arylsulfatase that catalyzes the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate. A deficiency of this enzyme is responsible for the inherited lysosomal disease, Maroteaux-Lamy syndrome (MUCOPOLYSACCHARIDOSIS VI). EC 3.1.6.12.
Mucopolysaccharidosis with excessive CHONDROITIN SULFATE B in urine, characterized by dwarfism and deafness. It is caused by a deficiency of N-ACETYLGALACTOSAMINE-4-SULFATASE (arylsulfatase B).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)
Exclusive legal rights or privileges applied to inventions, plants, etc.
The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.
An autosomal recessive metabolic disorder caused by a deficiency of GALACTOSYLCERAMIDASE leading to intralysosomal accumulation of galactolipids such as GALACTOSYLCERAMIDES and PSYCHOSINE. It is characterized by demyelination associated with large multinucleated globoid cells, predominantly involving the white matter of the central nervous system. The loss of MYELIN disrupts normal conduction of nerve impulses.
GLYCOSPHINGOLIPIDS with a sulfate group esterified to one of the sugar groups.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Infections with bacteria of the genus PSEUDOMONAS.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
The portion of an interactive computer program that issues messages to and receives commands from a user.
A mammalian beta-hexosaminidase isoform that is a heteromeric protein comprized of both hexosaminidase alpha and hexosaminidase beta subunits. Deficiency of hexosaminidase A due to mutations in the gene encoding the hexosaminidase alpha subunit is a case of TAY-SACHS DISEASE. Deficiency of hexosaminidase A and HEXOSAMINIDASE B due to mutations in the gene encoding the hexosaminidase beta subunit is a case of SANDHOFF DISEASE.
An inborn error of metabolism marked by a defect in the lysosomal isoform of BETA-MANNOSIDASE that results in lysosomal accumulation of mannose-rich intermediate metabolites containing 1,4-beta linkages. The human disease occurs through autosomal recessive inheritance and manifests itself with variety of symptoms that depend upon the type of gene mutation.
A general class of integral membrane proteins that transport ions across a membrane against an electrochemical gradient.
A group of hydrolases which catalyze the hydrolysis of monophosphoric esters with the production of one mole of orthophosphate. EC 3.1.3.
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in nature. Some species are pathogenic for humans, animals, and plants.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
An element with atomic symbol Cd, atomic number 48, and atomic weight 114. It is a metal and ingestion will lead to CADMIUM POISONING.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A species of gram-positive bacteria in the family STAPHYLOCOCCACEAE. It commonly causes urinary tract infections in humans.

Enzymatic and immunological characterization of the Mycobacterium fortuitum complex. (1/249)

The arylsulfatase isozymes of Mycobacterium fortuitum, M. peregrinum, M. chelonei subsp. chelonei, and M. chelonei subsp. abscessus were examined to determine the isozymal and immunological relationship among the members of the M. fortuitum complex. Cell extracts were subjected to electrophoresis on agarose and polyacrylamide gel, and arylsulfatase activity was localized using beta-naphthyl sulfate as substrate. Unique zymograms were produced for M. fortuitum, M. peregrinum, and M. chelonei which were characteristic for each species. The immunological relationship among the sulfatases was assayed by using immunodiffusion and immunoelectrophoresis followed by sulfatase staining for the enzyme. One of the isozymes of M. fortuitum and M. peregrinum cross-reacted, showing immunological identity. Antisera to sulfatases of M. fortuitum and M. peregrinum did not react with sulfatases of M. chelonei. The characterization of sulfatase isozymes in extracts of organisms in the M. fortuitum complex suggests the division of the M. fortuitum complex into two species, M. fortuitum and M. chelonei, with subspecies designations.  (+info)

Induction of selected lipid metabolic enzymes and differentiation-linked structural proteins by air exposure in fetal rat skin explants. (2/249)

The epidermal permeability barrier of premature infants matures rapidly following birth. Previous studies suggest that air exposure could contribute to this acceleration, because: (i) development of a structurally and functionally mature barrier accelerates when fetal rat skin explants are incubated at an air-medium interface, and (ii) occlusion with a water-impermeable membrane prevents this acceleration. To investigate further the effects of air exposure on epidermal barrier ontogenesis, we compared the activities of several key enzymes of lipid metabolism and gene expression of protein markers of epidermal differentiation in fetal rat skin explants grown immersed versus air exposed. The rate-limiting enzymes of cholesterol (HMG CoA reductase) and ceramide (serine palmitoyl transferase) synthesis were not affected. In contrast, the normal developmental increases in activities of glucosylceramide synthase and cholesterol sulfotransferase, responsible for the synthesis of glucosylceramides and cholesterol sulfate, respectively, were accelerated further by air exposure. Additionally, two enzymes required for the final stages of barrier maturation and essential for normal stratum corneum function, beta-glucocerebrosidase, which converts glucosylceramide to ceramide, and steroid sulfatase, which desulfates cholesterol sulfate, also increased with air exposure. Furthermore, filaggrin and loricrin mRNA levels, and filaggrin, loricrin, and involucrin protein levels all increased with air exposure. Finally, occlusion with a water-impermeable membrane prevented both the air-exposure-induced increase in lipid enzyme activity, and the expression of loricrin, filaggrin, and involucrin. Thus, air exposure stimulates selected lipid metabolic enzymes and the gene expression of key structural proteins in fetal epidermis, providing a biochemical basis for air-induced acceleration of permeability barrier maturation in premature infants.  (+info)

HpEts, an ets-related transcription factor implicated in primary mesenchyme cell differentiation in the sea urchin embryo. (3/249)

The mechanism of micromere specification is one of the central issues in sea urchin development. In this study we have identified a sea urchin homologue of ets 1 + 2. HpEts, which is maternally expressed ubiquitously during the cleavage stage and which expression becomes restricted to the skeletogenic primary mesenchyme cells (PMC) after the hatching blastula stage. The overexpression of HpEts by mRNA injection into fertilized eggs alters the cell fate of non-PMC to migratory PMC. HpEts induces the expression of a PMC-specific spicule matrix protein, SM50, but suppresses of aboral ectoderm-specific arylsulfatase and endoderm-specific HpEndo16. The overexpression of dominant negative delta HpEts which lacks the N terminal domain, in contrast, specifically represses SM50 expression and development of the spicule. In the upstream region of the SM50 gene there exists an ets binding site that functions as a positive cis-regulatory element. The results suggest that HpEts plays a key role in the differentiation of PMCs in sea urchin embryogenesis.  (+info)

An Asn > Lys substitution in saposin B involving a conserved amino acidic residue and leading to the loss of the single N-glycosylation site in a patient with metachromatic leukodystrophy and normal arylsulphatase A activity. (4/249)

Sphingolipid activator proteins are small glycoproteins required for the degradation of sphingolipids by specific lysosomal hydrolases. Four of them, called saposins, are encoded by the prosaposin gene, the product of which is proteolytically cleaved into the four mature saposin proteins (saposins A, B, C, D). One of these, saposin B, is necessary in the hydrolysis of sulphatide by arylsulphatase A where it presents the solubilised substrate to the enzyme. As an alternative to arylsulphatase A deficiency, deficiency of saposin B causes metachromatic leukodystrophy. We identified a previously undescribed mutation (N215K) in the prosaposin gene of a patient with metachromatic leukodystrophy but with normal arylsulphatase A activity and elevated sulphatide in urine. The mutation involves a highly conserved amino acidic residue and abolishes the only N-glycosylation site of saposin B.  (+info)

Induction of coproporphyrinogen oxidase in Chlamydomonas chloroplasts occurs via transcriptional regulation of Cpx1 mediated by copper response elements and increased translation from a copper deficiency-specific form of the transcript. (5/249)

Coproporphyrinogen III oxidase, encoded by a single nuclear gene in Chlamydomonas reinhardtii, produces three distinct transcripts. One of these transcripts is greatly induced in copper-deficient cells by transcriptional activation, whereas the other forms are copper-insensitive. The induced form of the transcript was expressed coordinately with the cytochrome c6-encoding (Cyc6) gene, which is known to be transcriptionally regulated in copper-deficient cells. The sequence GTAC, which forms the core of a copper response element associated with the Cyc6 gene, is also essential for induction of the Cpx1 gene, suggesting that both are targets of the same signal transduction pathway. The constitutive and induced Cpx1 transcripts have the same half-lives in vivo, and all encode the same polypeptide with a chloroplast-targeting transit sequence, but the shortest one representing the induced form is a 2-4-fold better template for translation than are either of the constitutive forms. The enzyme remains localized to a soluble compartment in the chloroplast even in induced cells, and its abundance is not affected when the tetrapyrrole pathway is manipulated either genetically or by gabaculine treatment.  (+info)

A novel mucin-sulphatase activity found in Burkholderia cepacia and Pseudomonas aeruginosa. (6/249)

Lung infections due to Burkholderia cepacia and Pseudomonas aeruginosa in patients with cystic fibrosis (CF) are common, are associated with respiratory morbidity and are a cause of mortality. Respiratory mucin in CF patients is highly sulphated, which increases its resistance to bacterial degradation. Desulphation increases the susceptibility of mucin to degradation by bacterial glycosidases and proteinases, and subsequent deglycosylation may facilitate bacterial colonisation by increasing available substrates and binding sites. This study determined whether clinical and environmental strains of B. cepacia and P. aeruginosa had the ability to desulphate mucin. Mucin-sulphatase activity was tested by incubating bacterial cell suspensions with 35S-sulphated mucins purified from LS174T and HT29-MTX human colon carcinoma cell lines. These mucins were also used to test for differences in substrate specificities. Mucin-sulphatase activity was detected in all nine B. cepacia strains and in four of six P. aeruginosa strains. There was strain variability in the level of mucin-sulphatase activity. Aryl-sulphatase activities of Pseudomonas isolates (determined with methylumbelliferyl sulphate) were c. 20-fold higher than those of B. cepacia strains, and were independent of mucin-sulphatase activity. This is the first report to demonstrate desulphation of mucin by B. cepacia and P. aeruginosa. It is concluded that B. cepacia and P. aeruginosa produce one or more cell-bound glycosulphatase(s), in addition to aryl-sulphatase activity. Mucin-sulphatase activity of B. cepacia and P. aeruginosa may contribute to their association with airway infections in patients with cystic fibrosis.  (+info)

Sac3, an Snf1-like serine/threonine kinase that positively and negatively regulates the responses of Chlamydomonas to sulfur limitation. (7/249)

The Sac3 gene product of Chlamydomonas positively and negatively regulates the responses of the cell to sulfur limitation. In wild-type cells, arylsulfatase activity is detected only during sulfur limitation. The sac3 mutant expresses arylsulfatase activity even when grown in nutrient-replete medium, which suggests that the Sac3 protein has a negative effect on the induction of arylsulfatase activity. In contrast to its effect on arylsulfatase activity, Sac3 positively regulates the high-affinity sulfate transport system-the sac3 mutant is unable to fully induce high-affinity sulfate transport during sulfur limitation. We have complemented the sac3 mutant and cloned a cDNA copy of the Sac3 gene. The deduced amino acid sequence of the Sac3 gene product is similar to the catalytic domain of the yeast Snf1 family of serine/threonine kinases and is therefore classified as a Snf1-related kinase (SnRK). Specifically, Sac3 falls within the SnRK2 subfamily of kinases from vascular plants. In addition to the 11 subdomains common to Snf1-like serine/threonine kinases, Sac3 and the plant kinases have two additional subdomains and a highly acidic C-terminal region. The role of Sac3 in the signal transduction system that regulates the responses of Chlamydomonas to sulfur limitation is discussed.  (+info)

Transposition of SRY into the ancestral pseudoautosomal region creates a new pseudoautosomal boundary in a progenitor of simian primates. (8/249)

We have isolated the prosimian lemur homologues for STS and SRY. FISH unambiguously co-localized STS with SHOX, IL3RA, ANT3 and PRK into the meiotic X-Y pairing region (PAR) of lemurs. In contrast to the close proximity of SRY to the pseudoautosomal boundary (PAB) on the Y chromosome in simian primates, SRY maps distant from the PAR in lemurs. Most interestingly, we were able to determine a DNA sequence divergence of 12.5% between the human and lemur SRY HMG box. This divergence directs to a 52 million year period of separate evolution of human and lemur SRY genes. Phylogenetically, this time period falls in between the times that prosimians and New World monkeys branched from the human lineage. Thus, we conclude that approximately 52 million years ago a transposition of SRY into the ancestral eutherian PAR distal to STS and PRK defined a new PAB in a simian progenitor. By this event, STS and PRK, amongst other genes, were excluded from the X-Y crossover process and thus became susceptible to rearrangements and/or deterioration on the Y chromosome in simian primates.  (+info)

Arylsulfatases: Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). EC 3.1.6.1.
Define Arylsulfatase E. Arylsulfatase E synonyms, Arylsulfatase E pronunciation, Arylsulfatase E translation, English dictionary definition of Arylsulfatase E. n. Chiefly British Slang Variant of ass2. or n 1. the buttocks 2. the anus 3. a stupid person; fool 4. sexual intercourse 5. Austral effrontery; cheek 6....
The pig endometrial arylsulphatase A was purified 3322-fold to a specific activity of 150 mumol/min per mg. The purification involved (NH4)2SO4 fractionation, chromatography on concanavalin A-Sepharose and DEAE-Sepharose, gel filtrations on Sephadex G-200 at pH 7.4 and 5, and a new preparative gel-electrophoresis technique. The homogeneous enzyme is a glycoprotein containing 20% carbohydrate. The purified enzyme has Mr about 120 000 and it contains subunits of Mr 63 000. The pig endometrial arylsulphatase A shows many properties in common with those of arylsulphatases A purified from other sources. The similarities include their low isoelectric points, the anomalous time-activity relationships, multi-pH optima, inhibition by SO3(2-), SO4(2-), phosphate ions, metal ions and nucleoside phosphates, pH- and ionic-strength-dependent polymerization and amino acid composition. ...
Bouchet, P. (2013). Charonia rubicunda (Perry, 1811). In: MolluscaBase (2017). Accessed through: Odido, M.; Appeltans, W.; BelHassen, M.; Mussai, P.; Nsiangango, S.E.; Vandepitte, L.; Wambiji, N.; Zamouri, N. Jiddou, A.M. (Eds) (2017). African Register of Marine Species at http://marinespecies.org/afremas/aphia.php?p=taxdetails&id=717009 on 2017-12- ...
Learn why horse owners should not be alarmed with a diagnosis of Lampas and why feeding a soft, moist ration is sometimes necessary if the horse has difficulty eating for a short time period.
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Arylsulfatase A antibody [N2C2], Internal (arylsulfatase A) for WB. Anti-Arylsulfatase A pAb (GTX106155) is tested in Human samples. 100% Ab-Assurance.
The relative activities of arylsulphatases A and B were measured in rat liver parenchymal and non-parenchymal cells, in peritoneal macrophages and in a number of rat tissues. Although absolute values cannot be obtained, it was shown that the arylsulphatase B/arylsulphatase A activity ratio is much higher in non-parenchymal cells than in parenchymal cells. The ratios in adrenals, brain and testis are very similar to each other but differ from those found in spleen, kidney and liver. These ratio variations may be caused by alterations in the activity of the B enzyme rather than the A enzyme. The relatively high B enzyme/A enzyme ratios in all rat tissues explains why the method devised for the independent assay of human arylsulphatases A and B cannot be employed with rat tissues.. ...
Fingerprint Dive into the research topics of Estrogen O-sulfamates and their analogues: clinical steroid sulfatase inhibitors with broad potential. Together they form a unique fingerprint. ...
ARSB : Arylsulfatase B (ARSB) can be measured with nitrocatechol sulfate as the substrate. The conditions established are such that arylsulfatase A activity is minimal and its residual activity can be accounted for and subtracted from the activity of ARSB.(Baum H, Dodgson KS, Spencer B: Assay of arylsulfatases A and B in human urine. Clin Chim Acta 1959;4:453-455)
Background endoplasmic reticulum lumen, arylsulfatase activity, glycosphingolipid metabolic process, post-translational protein modification Description ARSH Polyclonal Antibody, FITC Conjugated. FITC. Raised in Rabbit....
Steroid sulfatase兔多克隆抗体(ab62219)可与人样本反应并经WB, IHC实验严格验证,被1篇文献引用。所有产品均提供质保服务,中国75%以上现货。
The new paper, entitled Structure-activity relationship of the clinical steroid sulfatase inhibitor Irosustat (STX64, BN83495), has appeared in the November issue of the journal and describes how the research team has modified the chemical structure of the drug to explore the effects on biological activity.. Picture showing how the drug molecule (right) interacts with the steroid sulfatase enzyme (left).. Referee reports on the paper were so strong that the journal ChemMedChem accorded it coveted VIP status and also invited the authors to design a cover feature for the publication.. Professor Potter, with colleagues Dr Lawrence Woo and Dr Mark Thomas of the Department of Pharmacy & Pharmacology, designed an imaginative cover feature illustrating the drug molecule flanked by renderings of the target enzyme, all superimposed upon a false colour staining of the target protein in malignant breast cancer cells.. The publisher Wiley has also issued a feature on this paper in its own Chem Views ...
The study was conducted in Adama town, on carcass samples collected from the Arsi breed of cattle with the objective of evaluating beef microbiological qualities with sta..
G. DUBOIS, J. C. TURPIN, N. BAUMANN; Electrophoretic Characterization of A and B Isoenzymes of Arylsulfatase. Biochem Soc Trans 1 April 1974; 2 (2): 256. doi: https://doi.org/10.1042/bst0020256. Download citation file:. ...
1HDH: 1.3 A Structure of Arylsulfatase from Pseudomonas Aeruginosa Establishes the Catalytic Mechanism of Sulfate Ester Cleavage in the Sulfatase Family.
New Jersey Superior Court, Appellate Division,Decided: October 29, 1985,King,Joseph Scalia argued the cause for appellant (Berry, Kagan, Privetera & Sahradnik, attorneys; Roberta Torre Quinn, on the brief).,JOHN ARSI, SR., PETITIONER-RESPONDENT, v. OCEAN COUNTY ROAD DEPARTMENT, RESPONDENT-APPELLANT
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
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The development of potent steroid sulfatase inhibitors is an important new therapeutic strategy for the treatment of postmenopausal women with breast cancer. A series of tricyclic coumarin sulfamates were synthesized, and their inhibitory properties were examined in vitro and in vivo. In a placental microsomal assay system, 667 COUMATE emerged as the most potent inhibitor with an IC50 of 8 nM. Administration of a single dose (10 mg/kg, p.o.) of 667 COUMATE inhibited rat liver estrone sulfatase activity by 93%. 667 COUMATE was devoid of estrogenicity, as indicated by its failure to stimulate the growth of uteri in ovariectomized rats. In vivo, estrone sulfate-stimulated growth of uteri in ovariectomized rats was inhibited by 667 COUMATE. Using the nitrosomethylurea-induced mammary tumor model, we found that 667 COUMATE caused regression of estrone sulfate-stimulated tumor growth in a dose-dependent manner. The identification of 667 COUMATE as a potent steroid sulfatase inhibitor will enable the
Arylsulfatase A (or cerebroside-sulfatase) is an enzyme that breaks down sulfatides, namely cerebroside 3-sulfate into cerebroside and sulfate. In humans, arylsulfatase A is encoded by the ARSA gene. A deficiency is associated with metachromatic leukodystrophy, an autosomal recessive disease. Arylsulfatase A is inhibited by phosphate, which forms a covalent bond with the active site 3-oxoalanine. GRCh38: Ensembl release 89: ENSG00000100299 - Ensembl, May 2017 GRCm38: Ensembl release 89: ENSMUSG00000022620 - Ensembl, May 2017 Human PubMed Reference:. Mouse PubMed Reference:. Stein C, Gieselmann V, Kreysing J, Schmidt B, Pohlmann R, Waheed A, Meyer HE, OBrien JS, von Figura K (January 1989). Cloning and expression of human arylsulfatase A. J. Biol. Chem. 264 (2): 1252-9. PMID 2562955. Matzner U, Herbst E, Hedayati KK, Lüllmann-Rauch R, Wessig C, Schröder S, Eistrup C, Möller C, Fogh J, Gieselmann V (May 2005). Enzyme replacement improves nervous system pathology and function in a mouse ...
A series of novel D-ring modified derivatives of estrone was synthesized and tested as inhibitors of steroid sulfatase (STS). The steroidal D-ring was cleaved via an iodoform reaction and thermal condensation of the resulting marrianolic acid derivative gave 16,17-seco-estra-1,3,5(10)-triene-16,17-imide derivatives, where a piperidinedione moiety is in place of the D-ring. This synthetic approach was found to give a higher overall yield than the literature method of Beckmann rearrangement. A range of alkyl side chains have been introduced on the nitrogen atom of the imido-ring and the corresponding 3-O-sulfamates synthesized. The new D-ring modified estrone derivatives bearing a propyl (39) and a 1-pyridin-3-ylmethyl (46) moiety had IC(50) values of 1 nM when tested in placental microsomes for the inhibition of STS. These compounds are therefore up to 18-fold more potent than EMATE, the very first highly potent irreversible steroidal STS inhibitor.
Although arylsulfatase A pseudodeficiency is characterized as a disease, about 1-2% of any population of clinically healthy people have two copies of the ARSA pseudodeficiency allele, identified by rs6151429. This does lead to low levels of arylsulfatase (ARSA).[PMID 1678251 ...
Presence of a lysosomal enzyme, arylsulfatase-A, in the prelysosome-endosome compartments of human cultured fibroblasts. Academic Article ...
Pseudomonas aeruginosa arylsulfatase (PAS) is a bacterial sulfatase capable ofhydrolyzing a range of sulfate esters. Recently, it has been demonstrated to also show very high proficiency for phosphate ester hydrolysis. Such proficient catalytic promiscuity is significant, as promiscuity has been suggested to play an important role in enzyme evolution. Additionally, a comparative study of the hydrolyses of the p-nitrophenyl phosphate and sulfate monoesters in aqueous solution has demonstrated that despite superficial similarities, the two reactions proceed through markedly different transition states with very different solvation effects, indicating that the requirements for the efficient catalysis of the two reactions by an enzyme will also be very different (and yet they are both catalyzed by thesame active site). This work explores the promiscuous phosphomonoesterase activity ofPAS. Specifically, we have investigated the identity of the most likely base for the initial activation of the ...
Updated: 2019/03/07 13:47:37. Note: The information contained in this handbook is for use by personnel of University of Iowa Health Care. No other use is implied or intended.. Vacutainer® and/or Microtainer® are registered trademarks of Becton, Dickinson & Company.. ...
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PubMedID: 27268575 | The systematic regulation of oyster CgIL17-1 and CgIL17-5 in response to air exposure. | Developmental and comparative immunology | 10/1/2016
Dodgson, K.S., Spencer, B. and Williams, K. (1956). „Studies on sulphatases. 13. The hydrolysis of substituted phenyl sulphates by the arylsulphatase of Alcaligenes metacaligenes. Biochem. J. 64: 216-221. PMID 13363831 ...
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With no concrete solutions on the table regarding the much-feared fiscal cliff, it wasnt terribly surprising to see equity markets take a beating last week. Profit-taking pressures have been a dominant ...
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TY - JOUR. T1 - The phenotype spectrum of X-linked ichthyosis identified by chromosomal microarray. AU - Hand, Jennifer L.. AU - Runke, Cassandra K.. AU - Hodge, Jennelle C.. PY - 2015/4/1. Y1 - 2015/4/1. N2 - Background Steroid sulfatase (STS) gene disruption causes X-linked ichthyosis (XLI). Interrogating the entire genome through chromosomal microarray (CMA), a test primarily used to screen patients with noncutaneous congenital anomalies, may detect STS deletions incidentally. Objective We sought to determine the variability of skin features associated with STS deletions diagnosed through CMA and to compare these findings with XLI cases reported in the literature and recognized in a dermatology clinic. Methods Male patients with an STS deletion were identified from 23,172 consecutive postnatal blood samples tested with CMA at Mayo Clinic. A comparison group of male patients with biochemically confirmed XLI was ascertained in the dermatology clinic. The available patient medical records, skin ...
TY - JOUR. T1 - A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C. AU - Sunohara, Nobuhiko. AU - Sakuragawa, Norio. AU - Satoyoshi, Eijiro. AU - Tanae, Ayako. AU - Shapiro, Larry J.. PY - 1986/2. Y1 - 1986/2. N2 - We describe a family consisting of 3 affected men with congenital ichthyosis, anosmia, hypogonadism, nystagmus with decreased visual acuity, strabismus, hypopigmentation of the iris, and mirror movements of the hands and feet. Two of them had limitation of ocular movement and unilateral renal agenesis or hypoplasia. The condition appears to be inherited as an X‐linked recessive trait. Clinical, pathological, and biochemical evaluations were compatible with a diagnosis of X‐linked ichthyosis. Steroid sulfatase and arylsulfatase C activities in leukocytes and fibroblasts were markedly diminished in the affected patients. Their hypogonadism was due to decreased luteninizing ...
On October 6, 2016 results were published in the PLOS journal regarding a recent X-Linked personality survey. The article is titled Behavioural and Psychiatric Phenotypes in Men and Boys with X-Linked Ichthyosis: Evidence from a Worldwide Online Survey. An abstract of the results can be found at: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164417. FIRST MSAB member, Dr. Jennifer Hand of the Mayo Clinic adds, This study is interesting but has important limitations to consider. Many of the individuals studied were collected from within patient support groups. This means that the study is likely biased towards individuals who had severe enough health concerns that they or their families sought out help from a support group. That is, this study probably overemphasizes the behavioral problems associated with XLI. A more meaningful result would come from a random sample of individuals found to have the gene deletion that causes X-linked ichthyosis.. ...
CR: Disappearance of all known disease & no new sites / disease related symptoms confirmed at least 12 weeks after initial documentation. Disappearance of all non-target lesions. Normalization of tumor marker level confirmed at least 12 weeks after initial documentation.. PR: Minimum 30% decrease in sum of the longest diameters of target lesions, taking as a reference the baseline sum of the longest diameters confirmed at least 12 weeks after initial documentation. PR is also recorded when all measurable disease has completely disappeared, but a non-measurable component (i.e., ascites) is still present but not progressing. As well as persistence of one or more non-target lesion(s) and/or maintenance of tumor marker level above normal limits.. RECIST defines SD for target lesions as neither sufficient shrinkage to qualify for partial response nor sufficient increase to qualify for progressive disease, no occurrence of progression disease for non-target lesions, and no new lesions. ...
Jiang M, Klein M, Zanger UM, Mohammad MK, Cave MC, Gaikwad NW, Dias NJ, Selcer KW, Guo Y, He J, Zhang X, Shen Q, Qin W, Li J, Li S, Xie W. Inflammatory regulation of steroid sulfatase: A novel mechanism to control estrogen homeostasis and inflammation in chronic liver disease. J Hepatol. 2016 Jan;64(1):44-52. doi: 10.1016/j.jhep.2015.07.022. Epub 2015 Jul 26. PubMed PMID: 26220752; PubMed Central PMCID: PMC4691383 ...
Random Tn917 mutagenesis of Bacillus subtilis followed by selection of lipoic acid auxotrophs led to the isolation of the cysH gene. The gene was sequenced and found to encode a phosphoadenylylsulfate sulfotransferase with a molecular mass of 27 kDa. Expression of lacZ fused to the cysH promoter was repressed by cysteine and sulfide and induced by sulfur limitation, indicating that cysH is controlled at the level of transcription. ...
1114 Recent studies have demonstrated the multi-mechanism anti-tumor effects of 2-substituted estradiol bis-sulfamates and highlighted a number of potential advantages that such compounds possess relative to the corresponding estradiols, which include 2-methoxyestradiol (2-MeOE2, Panzem ™) a drug in Phase II clinical trials. 2-Methoxy- (2-MeOE2bisMATE, STX140, 1) and 2-ethyl-estradiol bis-sulfamate (2-EtE2bisMATE, STX243, 2) display potent anti-proliferative and anti-angiogenic activity and also function as inhibitors of steroid sulphatase (STS), a clinical target for the treatment of hormone dependent breast cancer. In order to generate novel agents with anti-proliferative activity against human breast cancer cells we have synthesised a number of 2-substituted estradiol 3-O-sulfamate analogues with oxygenated side chains tethered at C-17 as bio-isosteric replacements of the 17-O-sulfamate group of the bisMATEs. The 17β-(2-hydroxyethyl) compound 3 in which the hydroxyl group can function as ...
If you have used this database, please ensure that you acknowledge this most recent Pseudomonas Genome Database publication rather than just the website URL. Thank you!. Winsor GL, Griffiths EJ, Lo R, Dhillon BK, Shay JA, Brinkman FS (2016 ...
Extracted Text: VOL. XLI, No. 3 WHOLE No. 219 MAY/JUNE 2002 CONFEDERATE & SOUTHERN STATES SPECIAL ISSUE C tl...
ARS-853 is the first direct KRAS inhibitor shown to selectively inhibit KRAS in cells with potency in the range of a drug candidate. Previously reported KRAS inhibitors have either shown insufficient potency for detailed cellular characterization (2, 3, 6), or exhibit dramatic deviations in potency across assays (4). The most potent covalent KRASG12C ligand reported previously (Compound 12) exhibited promising in vitro properties, but its cellular effects were less clear (6). Here, we demonstrate that Compound 12 is not capable of engaging KRASG12C in cells even at a relatively high dose and long incubation (100 μmol/L for 6 hours). However, by improving upon the groundbreaking approach of targeting the Switch II pocket of KRASG12C with covalent ligands, we have successfully identified a covalent inhibitor that demonstrates consistent low micromolar activity from biochemical and cellular engagement to KRASG12C activation, downstream signaling, and cell survival. Further, we have found that ...
Nadar, Venkadesh Sarkarai; Yoshinaga, Masafumi; Pawitwar, Shashank S et al. (2016) Structure of the ArsI C-As Lyase: Insights into the Mechanism of Degradation of Organoarsenical Herbicides and Growth Promoters. J Mol Biol 428:2462-73 ...
A middle-aged woman had suffered for a few months from vomiting, pain in the abdomen, and loss of flesh. Examination showed a large tumour in the umbilical region and left hypochondrium, which was som...
The Apalert Respiration Monitor makes care of veterinary patients much easier by signaling each breath, measuring the time between breaths and by alarming if breathing stops, slows or becomes ...
TY - JOUR. T1 - Differential expression of steroid sulphatase locus on active and inactive human X chromosome. AU - Migeon, Barbara R. AU - Shapiro, Larry J.. AU - Norum, Robert A.. AU - Mohandas, Thuluvancheri. AU - Axelman, Joyce. AU - Dabora, Rebecca L.. PY - 1982. Y1 - 1982. N2 - The X chromosome in mammalian somatic cells is subject to unique regulation - usually genes on a single X chromosome are expressed while those on other X chromosomes are inactivated1. The X-locus for steroid sulphatase (STS; EC 3.1.6.2), the microsomal enzyme that catalyses the hydrolysis of various 3β-hydroxysteroid sulphates, is exceptional because it seems to escape inactivation. Evidence for this comes from fibroblast clones in females heterozygous for mutations that result in a severe deficiency of this enzyme in affected males; all clones from these heterozygotes have STS activity, and enzyme-deficient clones that are expected if the locus were subject to inactivation2, have not been found3. Further evidence ...
X-linked ichthyosis is a relatively common genetic disorder of keratinization. It is the second most common type of ichthyosis after vulgaris. The incidence is estimated to be between 1 in 2,000 and...
Multiplex polymerase chain reaction (Multiplex PCR) refers to the use of polymerase chain reaction to amplify several different DNA sequences simultaneously (as if performing many separate PCR reactions all together in one reaction). This process amplifies DNA in samples using multiple primers and a temperature-mediated DNA polymerase in a thermal cycler. The primer design for all primers pairs has to be optimized so that all primer pairs can work at the same annealing temperature during PCR. Multiplex-PCR was first described in 1988 as a method to detect deletions in the dystrophin gene. It has also been used with the steroid sulfatase gene. In 2008, multiplex-PCR was used for analysis of microsatellites and SNPs. Multiplex-PCR consists of multiple primer sets within a single PCR mixture to produce amplicons of varying sizes that are specific to different DNA sequences. By targeting multiple sequences at once, additional information may be gained from a single test run that otherwise would ...
Arylsulfatase A (ASA) is a lysosomal enzyme involved in the catabolism of cerebroside sulfate. ASA deficiency is associated with metachromatic leukodystrophy (MLD). Low ASA activities have also been reported in a more common condition with no apparent clinical consequences termed ASA pseudo-deficiency (ASA-PD) which is associated with two linked mutations in the ASA gene (c.1049A | G and c.*96A | G). This study aimed to investigate the frequency of the two ASA-PD variants and their linkage disequilibrium (LD) among Tunisians. ASA-PD variants were detected in 129 healthy Tunisians and their frequencies were compared to those described worldwide. The frequency of the PD allele was estimated at 17.4 % for the overall sample, with c.1049A | G and c.*96A | G frequencies of 25.6 and 17.4 %, respectively. This study also revealed a high LD between the two ASA-PD variants (r (2) = 0.61). Inter-population analysis revealed similarities in the ASA-PD genetic structure between Tunisians and populations from Middle
This trial will explore the safety and efficacy of BN83485 compared to Megestrol Acetate (MA) on progression free survival (PFS) in post menopausal pati
Lai, Rasha Elgag Elsadig, Karin Reimann, Cheng Har Yip and Leslie (2001) Inhibition of oestrone sulphatase activity in the MDA-MB-231 Breast Cancer Cell Line by Breast Cyst Fluid from Malaysian Women. Anticancer Research, 21. pp. 2693-2696. ...
|strong|Mouse anti Human Sulfatase 2 (C-Terminal) antibody, clone 2B4|/strong| recognizes an epitope within the C-terminal (CT) subunit of Sulfatase 2 (Sulf-2). Sulf-2 is a novel extracellular heparan…
Mouse anti Human Sulfatase 2 (C-Terminal) antibody, clone 2B4 recognizes an epitope within the C-terminal (CT) subunit of Sulfatase 2 (Sul
Presented by Mesay Yami (EIAR Kulumsa Agricultural Research Centre) at the Africa-RISING Quick Feed Project Inception Workshop, Addis Ababa, 7-8 May 2012
Abcam provides specific protocols for Anti-Iduronate 2 sulfatase antibody (ab85701) : Western blot protocols, Immunohistochemistry protocols
Sulfatase 2兔多克隆抗体(ab101057)可与人样本反应并经WB, ICC/IF实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
Creed Pearsons Scientology doubt formula - The Biggest Secrets of Scientology - A (25 year member) Discovering Scientology s Greatest Secret and Why I was Silenced, by Creed J. Pearson May 2005 To those who care: Before I begin this rather lengthy expose , I would like the reader to read the affirmations of L. Ron Hubbard written in 1947. These are also known as the admissions. It was only after reading these and continuing my research that I was able to finally come out of doubt for real. These are not OT levels and are not confidential. To read these, see http://www.gerryarmstrong.org/50grand/writings/ars/ars-2000-03-11.html.
... sea urchin embryo arylsulfatase EC 3.1.6.1; green algae arylsulfatase EC 3.1.6.1, which plays a role in the mineralization of ... "Phylogenetic conservation of arylsulfatases. cDNA cloning and expression of human arylsulfatase B". J. Biol. Chem. 265 (6): ... Grossman AR, de Hostos EL, Schilling J (1989). "Structure and expression of the gene encoding the periplasmic arylsulfatase of ... arylsulfatase C (ASD) and E (ASE); steryl-sulfatase EC 3.1.6.2 (STS), a membrane bound enzyme which hydrolyzes 3-beta-hydroxy ...
Arylsulfatase A is activated by saposin B (Sap B), a non-enzymatic proteinaceous cofactor. When the arylsulfatase A enzyme ... MLD is directly caused by a deficiency of the enzyme arylsulfatase A (ARSA) and is characterized by enzyme activity in ... These cells are transduced ex vivo using a lentiviral vector encoding the human arylsulfatase A gene to insert a functional ... "Arylsulfatase A Deficiency: Metachromatic Leukodystrophy, ARSA Deficiency". GeneReviews, 2006 Kishimoto Y, Hiraiwa M, O'Brien ...
Arylsulfatase B Farooqui AA (October 1976). "The desulphation of hexosamine sulphates by arylsulphatase B". Experientia. 32 (10 ... Gorham SD, Cantz M (December 1978). "Arylsulphatase B, an exo-sulphatase for chondroitin 4-sulphate tetrasaccharide". Hoppe- ... N-acetylgalactosamine-4-sulfatase (EC 3.1.6.12, chondroitinsulfatase, chondroitinase, arylsulfatase B, acetylgalactosamine 4- ... arylsulfatase), and chondroitin 4-sulfatase". Biochimica et Biophysica Acta. 612 (2): 373-83. doi:10.1016/0005-2744(80)90120-5 ...
... produces arylsulfatase, biphenomycin A, cinerubin A and cinerubin B. List of Streptomyces ... Ueki, T; Sawada, Y; Fukagawa, Y; Oki, T (June 1995). "Arylsulfatase from Streptomyces griseorubiginosus S980-14". Bioscience, ...
Arylsulfatase A Mehl E, Jatzkewitz H (1964). "[A cerebrosidesulfatase from swine kidney]". Hoppe-Seyler's Zeitschrift für ... Cerebroside-sulfatase (EC 3.1.6.8, arylsulfatase A, cerebroside sulfate sulfatase) is an enzyme with systematic name ...
It is believed to be caused by a deficiency in arylsulfatase A. Arylsulfatase A is a lysosomal sulfatase that is able to ... Saposin B extracts sulfatide from the membrane, which makes it accessible to arylsulfatase A. Arylsulfatase A can then ... Here, arylsulfatase A hydrolyzes the sulfate group. However, in order for this reaction to be carried out, a sphingolipid ... a lysosomal storage disease and may be caused because of a defect in arylsulfatase A, leading to an inability to degrade ...
Low arylsulphatase A activity can occur in healthy individuals. This poses a challenge in genetic testing, making it difficult ... Barth ML, Ward C, Harris A, Saad A, Fensom A (1994). "Frequency of arylsulphatase A pseudodeficiency associated mutations in a ...
Arylsulfatase test Arylsulfatase enzyme is present in most mycobacteria. The rate by which arylsulfatase enzyme breaks down ... 3 day arylsulfatase test is used to identify potentially pathogenic rapid growers such as M. fortuitum and M. chelonae. Slow ... growing M. marinum and M. szulgai are positive in the 14-day arylsulfatase test. Catalase, semiquantitative activity Most ...
Further analysis has linked alkaline phosphates and aryl sulfatases to a larger superfamily. Some of the common genes found in ... Research has shown a relationship between members of the alkaline phosphatase family with aryl sulfatases. The similarities in ...
1989). "Cloning and expression of human arylsulfatase A". J. Biol. Chem. 264 (2): 1252-9. PMID 2562955. Fleischer B, Zambrano F ...
... (STS), or steryl-sulfatase (EC 3.1.6.2), formerly known as arylsulfatase C, is a sulfatase enzyme involved in ... Shankaran R, Ameen M, Daniel WL, Davidson RG, Chang PL (June 1991). "Characterization of arylsulfatase C isozymes from human ... "Entrez Gene: STS steroid sulfatase (microsomal), arylsulfatase C, isozyme S". Mueller JW, Gilligan LC, Idkowiak J, Arlt W, ... Munroe DG, Chang PL (February 1987). "Tissue-specific expression of human arylsulfatase-C isozymes and steroid sulfatase". ...
Farooqui, Bachhawat B. K. (1973). "Enzymic desulfation of cerebroside-3'-sulfate by chicken brain arylsulfatase". J. Neurochem ... was caused by the absence of Arylsulfatase A, an enzyme responsible for the breaking down on sulfatides. This discovery ...
Positive for arylsulfatase activity (3 days) and Tween 80 hydrolysis. Produces a low level of heatstable catalase and is ...
Tobacman JK (June 2003). "Does deficiency of arylsulfatase B have a role in cystic fibrosis?". Chest. 123 (6): 2130-9. doi: ... arylsulphatase - which is necessary for Mycobacterium tuberculosis virulence. As M. tuberculosis would use its host's sources ...
"Characterization of a Recombinant Thermostable Arylsulfatase from Deep-Sea Bacterium Flammeovirga pacifica". Journal of ...
Mutations in this gene result in a deficiency of arylsulfatase E. Only 50-60% of cases have been shown to have mutations in ... The mutation that leads to a deficiency in arylsulfatase E. (ARSE) occurs in the coding region of the gene. Absence of ... This condition is also known as arylsulfatase E deficiency, CDPX1, and X-linked recessive chondrodysplasia punctata 1. The ... April 2008). "Clinical and molecular analysis of arylsulfatase E in patients with brachytelephalangic chondrodysplasia punctata ...
The organism fails to show Tween 80 hydrolysis, nitrate reduction, or arylsulfatase activity. It does not gro on Middlebrook ...
... and Sulf2 are new members of a superfamily of arylsulfatases, being closely related to arylsulfatase A, B (ARSA; ARSB) ... However, this paradigm changed after the discovery of two extracellular 6-O-S glucosamine arylsulfatases, Sulf1 and Sulf2. ... "Amino acid residues forming the active site of arylsulfatase A. Role in catalytic activity and substrate binding". The Journal ...
"Terminal 22q deletion associated with a partial deficiency of arylsulphatase A". Journal of Medical Genetics. 29 (6): 432-3. ...
... is an inherited disease caused by a deficiency in the enzyme arylsulfatase B (ARSB). ASRB is responsible for the breakdown of ... functional characterization of pathogenic mutations and polymorphisms in the arylsulfatase B gene". Mol. Genet. Metab. 94 (3): ...
no tolerance to 5% NaCl, positive for Tween 80 hydrolysis and for 10-day-arylsulfatase. Negative for production of nicotinic ...
Key differentiating features are negative tests for arylsulfatase and pyrazinamidase and susceptibility to antimycobacterial ...
The hydrolysis of substituted phenyl sulphates by the arylsulphatase of Alcaligenes metacaligenes". Biochem. J. 64: 216-221. ...
... has a strong sequence homology with human arylsulfatases A, B, and C, and human glucosamine-6-sulfatase. ...
"Defective endoplasmic reticulum-resident membrane protein CLN6 affects lysosomal degradation of endocytosed arylsulfatase A." J ...
This organism was found to be positive in a nitrate reduction test and negative in the aryl sulfatase test that were performed ... The 484t strain was found to be negative for tellurite reduction as well as activity with aryl sulphatase. The optimal growth ...
Growth occurs at 37 to 50 °C. The type strain is positive for 10-d arylsulfatase and pyrazinamidase. Negative for 3-d ... arylsulfatase, urease, nitrate reductase, semi-quantitative catalase, heat-stable catalase, acid phosphatase, b-galactosidase ...
M. abscessus has also been shown to produce arylsulfatase, but not of nitrate reductase and Tween 80 hydrolase. It shows a ...
Strongly positive for arylsulfatase activity in 14-day tests and moderately to weakly positive for nicotinamidase and ...
Known substrates for SUMF1 are: N-acetylgalactosamine-6-sulfate sulfatase (GALNS), arylsulfatase A (ARSA), steroid sulfatase ( ... STS) and arylsulfatase E (ARSE); all molecules that contain cysteine. FGE converts this cysteine group into C-𝛼-formylglycine. ...
Types include: Arylsulfatase A (also known as "cerebroside-sulfatase") Arylsulfatase B (also known as "N-Acetylgalactosamine-4- ... Arylsulfatase (EC 3.1.6.1, sulfatase, nitrocatechol sulfatase, phenolsulfatase, phenylsulfatase, p-nitrophenyl sulfatase, ... The hydrolysis of substituted phenyl sulphates by the arylsulphatase of Alcaligenes metalcaligenes". The Biochemical Journal. ... Sulfatase") Steroid sulfatase (formerly known as "Arylsulfatase C") ARSC2 ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK Aryl Dodgson ...
Arylsulfatase E, also known as ARSE, is an enzyme that, in humans, is encoded by the ARSE gene. Arylsulfatase E is a member of ... Urbitsch P, Salzer MJ, Hirschmann P, Vogt PH (2000). "Arylsulfatase D gene in Xp22.3 encodes two protein isoforms". DNA Cell ... 1998). "Biochemical characterization of arylsulfatase E and functional analysis of mutations found in patients with X-linked ... 1997). "Identification by shotgun sequencing, genomic organization, and functional analysis of a fourth arylsulfatase gene ( ...
arylsulfatase D. Locus tag. CR201_G0050936. See related. Ensembl:ENSPPYG00000020093 Gene type. protein coding. RefSeq status. ... AslA; Arylsulfatase A or related enzyme [Inorganic ion transport and metabolism]. cl23718. Location:40 → 563. ALP_like; ... XM_024241537.1 → XP_024097305.1 arylsulfatase D isoform X2. Conserved Domains (1) summary. cl23718. Location:40 → 333. ALP_like ... XM_009234566.2 → XP_009232841.1 arylsulfatase D isoform X1. UniProtKB/TrEMBL. H2PUT6 Related. ENSPPYP00000022473 Conserved ...
Arylsulfatase E pronunciation, Arylsulfatase E translation, English dictionary definition of Arylsulfatase E. n. Chiefly ... redirected from Arylsulfatase E). Also found in: Thesaurus, Medical, Acronyms.. Related to Arylsulfatase E: Arylsulfatase D ... Arylsulfatase E - definition of Arylsulfatase E by The Free Dictionary https://www.thefreedictionary.com/Arylsulfatase+E ...
Crystal structure of human arylsulfatase A: the aldehyde function and the metal ion at the active site suggest a novel ... ARYLSULFATASE A protein, length: 489 (BLAST) Sequence Similarity Cutoff. Rank. Chains in Cluster. Cluster ID / Name. Structural ...
This disorder is distinct from conditions caused by deficiencies of arylsulfatase B (Maroteaux-Lamy disease) and arylsulfatase ... Arylsulfatase A is also deficient in individuals with multiple sulfatase deficiency.. ... Individuals with pseudodeficiency of arylsulfatase A may have decreased enzyme activity and are not clinically affected with ...
Compare Arylsulfatase A ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and ... Arylsulfatase A ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for detecting and ... Your search returned 129 Arylsulfatase A ELISA ELISA Kit across 17 suppliers. ...
Arylsulfatase A, B, and C have been separated. A deficiency of arylsulfatases is one of the causes of metachromatic ... Arylsulfatases: Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a phenol and sulfate. ... "Study of the molecular forms of arylsulfatases confirmed the complete deficiency of arylsulfatase A and arylsulfatase B ... Arylsulfatases. Subscribe to New Research on Arylsulfatases Enzymes that catalyze the hydrolysis of a phenol sulfate to yield a ...
ARYLSULFATASE. A, B. 536. Pseudomonas aeruginosa. Mutation(s): 8 EC: 3.1.6.1. ... G9 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa. *DOI: 10.2210/pdb4CXK/pdb ... we performed the laboratory evolution of an arylsulfatase to improve its initially weak phenylphosphonate hydrolase activity. ...
This does lead to low levels of arylsulfatase (ARSA).[PMID 1678251. ] Other mutations in the ARSA gene lead to metachromatic ... Although arylsulfatase A pseudodeficiency is characterized as a disease, about 1-2% of any population of clinically healthy ... Retrieved from "https://www.SNPedia.com/index.php?title=Arylsulfatase_A_pseudodeficiency&oldid=1059118" ...
Arylsulfatase BImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a ... tr,F6TYS7,F6TYS7_HORSE Arylsulfatase B OS=Equus caballus OX=9796 GN=ARSB PE=4 SV=2 ...
Compare arylsulfatase family member I ELISA Kits from leading suppliers on Biocompare. View specifications, prices, citations, ... arylsulfatase family member I ELISA Kits. The ELISA (enzyme-linked immunosorbent assay) is a widely used application for ... Your search returned 13 arylsulfatase family member I ELISA ELISA Kit across 1 supplier. ...
The conditions established are such that arylsulfatase A activity is minimal and its residual activity can be accounted for and ... subtracted from the activity of ARSB.(Baum H, Dodgson KS, Spencer B: Assay of arylsulfatases A and B in human urine. Clin Chim ... Arylsulfatase B (ARSB) can be measured with nitrocatechol sulfate as the substrate. ... Arylsulfatase B (ARSB) can be measured with nitrocatechol sulfate as the substrate. The conditions established are such that ...
... arylsulfatase activity, glycosphingolipid metabolic process, post-translational protein modification ... arylsulfatase activity Source: HGNC ,p>Traceable Author Statement,/p> ,p>Used for information from review articles where the ... R-HSA-1663150. The activation of arylsulfatases. Miscellaneous databases. ChiTaRS: a database of human, mouse and fruit fly ... sp,Q5FYB0,ARSJ_HUMAN Arylsulfatase J OS=Homo sapiens OX=9606 GN=ARSJ PE=2 SV=1 ...
Browse our Arylsulfatase B/ARSB Protein catalog backed by our Guarantee+. ... Arylsulfatase B/ARSB Proteins available through Novus Biologicals. ... Arylsulfatase B/ARSB Proteins. We offer Arylsulfatase B/ARSB Peptides and Arylsulfatase B/ARSB Proteins for use in common ... Alternate Names for Arylsulfatase B/ARSB Proteins. Arylsulfatase B/ARSB protein, ARSB protein, arylsulfatase B protein, ASB ...
Selected quality suppliers for anti-Arylsulfatase B antibodies. ... Order monoclonal and polyclonal Arylsulfatase B antibodies for ... arylsulfatase B structural , arylsulfatase B temporal regulation , Arylsulfatase B (MPS VI) , arylsulfatase B , arylsulfatase b ... Arylsulfatase B (ARSB) Polyclonal Host: Rabbit WB ELISA IgG Biotin FITC HRP IHC Reactivity: Cow (Bovine) ... Arylsulfatase B (ARSB) Antigen Profile Protein Summary Arylsulfatase B encoded by this gene belongs to the sulfatase family. ...
Pseudomonas aeruginosa arylsulfatase (PAS) is a bacterial sulfatase capable ofhydrolyzing a range of sulfate esters. Recently, ... Examining the promiscuous phosphatase activity of Pseudomonas aeruginosa arylsulfatase: A comparison to analogous phosphatases ...
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... arylsulfatase D) for ELISA, ICC/IF, IHC-P. Anti-Arylsulfatase D pAb (GTX87652) is tested in Human samples. 100% Ab-Assurance. ... arylsulfatase D. Background. The protein encoded by this gene is a member of the sulfatase family. Sulfatases are essential for ... Storage Conditions: Arylsulfatase D antibody. Storage Buffer. Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM ... The antiserum was produced against synthesized peptide derived from human Arylsulfatase D. ...
Electrophoretic Characterization of A and B Isoenzymes of Arylsulfatase G. DUBOIS; G. DUBOIS ... G. DUBOIS, J. C. TURPIN, N. BAUMANN; Electrophoretic Characterization of A and B Isoenzymes of Arylsulfatase. Biochem Soc Trans ...
Arylsulfatase A (transcript variant 1). Not available. Recombinant protein of human arylsulfatase A (ARSA), transcript variant ... Arylsulfatase A (transcript variant 2). Not available. Purified recombinant protein of Homo sapiens arylsulfatase A (ARSA), ... Arylsulfatase A (transcript variant 4). Not available. Purified recombinant protein of Homo sapiens arylsulfatase A (ARSA), ... Arylsulfatase A (transcript variant 1). Not available. Recombinant protein of human arylsulfatase A (ARSA), transcript variant ...
Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for ... Abstract: BACKGROUND:Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate ... Arylsulfatase B is reduced in prostate cancer recurrences Article type: Research Article ...
OMIM: ARYLSULFATASE I; ARSI*Gene Ontology: Arsi *Mouse Phenome DB: Arsi *UCSC: Chr.18:60,912,240-60,917,768(+)*IMPC: Arsi ... arylsulfatase i. Gene nomenclature, locus information, and GO, OMIM, and PMID associations are updated daily from MGI ...
The pig endometrial arylsulphatase A was purified 3322-fold to a specific activity of 150 mumol/min per mg. The purification ... The pig endometrial arylsulphatase A shows many properties in common with those of arylsulphatases A purified from other ... Isolation and characterization of the pig endometrial arylsulphatase A. Message Subject (Your Name) has forwarded a page to you ... Isolation and characterization of the pig endometrial arylsulphatase A.. H Rahi, P N Srivastava ...
Electrophoretic Characterization of A and B Isoenzymes of Arylsulfatase. G. DUBOIS, J. C. TURPIN, N. BAUMANN ... Electrophoretic Characterization of A and B Isoenzymes of Arylsulfatase Message Subject (Your Name) has forwarded a page to you ...
Improving arylsulfatase activity determination in dried blood spots: Screening and diagnostic approaches for Maroteaux-Lamy ... Mucopolysaccharidosis type VI can be screened by measuring the lysosomal arylsulfatase B (ARSB) residual enzyme activity in ...
Wilsons disease with Leu492Ser mutation and arylsulfatase A pseudodeficiency: just a coincidence?. *C. Battisti1. , ... Battisti, C., Dotti, M.T., Loudianos, G. et al. Wilsons disease with Leu492Ser mutation and arylsulfatase A pseudodeficiency: ... is associated with neurological presentation of the disease and arylsulfatase A pseudeficiency. ...
... shRNA and Lentiviral Particle Gene Silencers are designed to knockdown gene expression of human Arylsulfatase I ... Arylsulfatase I siRNA and shRNA Plasmids (h)human Arylsulfatase I-specific siRNA, shRNA Plasmid and Lentiviral Particle gene ... Target species: human; for corresponding mouse product, see Arylsulfatase I siRNA and shRNA Plasmids (m) ... Arylsulfatase I siRNA and shRNA Plasmids (h). *bvseo_sdk, java_sdk, bvseo-3.2.0 ...
... shRNA and Lentiviral Particle Gene Silencers are designed to knockdown gene expression of human Arylsulfatase H ... Arylsulfatase H siRNA and shRNA Plasmids (h)human Arylsulfatase H-specific siRNA, shRNA Plasmid and Lentiviral Particle gene ... Arylsulfatase H siRNA and shRNA Plasmids (h). *bvseo_sdk, java_sdk, bvseo-3.2.0 ... Arylsulfatase H Primer (h) includes A set (forward & reverse) and B set (forward & reverse) primers ...
... and arylsulfatase, and scanning electron microscopy using osmium maceration to assess the three-dimensional morphology of the ... The nuclear membrane showed strong arylsulfatase activity as well as rough endoplasmic reticulum and lysosomes. Scanning ... Three-dimensional morphology of the Golgi apparatus in osteoclasts: NADPase and arylsulfatase cytochemistry, and scanning ... and arylsulfatase, and scanning electron microscopy using osmium maceration to assess the three-dimensional morphology of the ...
  • Individuals with pseudodeficiency of arylsulfatase A may have decreased enzyme activity and are not clinically affected with metachromatic leukodystrophy. (uiowa.edu)
  • A deficiency of arylsulfatases is one of the causes of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). (curehunter.com)
  • In a patient with early onset dementia, strategic diagnostic workup including genetic assessment revealed an adult-onset metachromatic leukodystrophy with a novel mutation in the arylsulfatase A gene. (iospress.com)
  • Metachromatic leukodystrophy (MLD) is a genetic disorder caused by the deficiency of the enzyme arylsulfatase A (ARSA) in lipid metabolism [1-3]. (thefreedictionary.com)
  • Occurrence, distribution, and phenotype of arylsulfatase A mutations in patients with metachromatic leukodystrophy. (mysciencework.com)
  • Occurrence, distribution, and phenotype of arylsulfatase A (ASA) mutations were investigated in 27 patients with metachromatic leukodystrophy (MLD) from Central Europe, mainly from Austria (n = 15) and Poland (n = 9). (mysciencework.com)
  • This biochemical test is a quantitative measurement of arylsulfatase A enzyme activity can be used as a 1st tier test for patients with a clinical suspicion of Metachromatic Leukodystrophy. (isinproduction.com)
  • Demonstration of deficient arylsulfatase A enzyme activity is considered the gold standard to confirm a diagnosis of Metachromatic Leukodystrophy. (isinproduction.com)
  • Metachromatic leukodystrophy is an autosomal recessive condition caused by a deficiency of arylsulfatase A, an enzyme crucial to the breakdown of sulfatides in the body. (isinproduction.com)
  • Metachromatic leukodystrophy (MLD) is an autosomal recessive inherited disorder in which the desulfation of 3-0-sulfogalactosyl-containing glycolipids by arylsulfatase A (ASA) is defective. (testcatalog.org)
  • Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by a deficiency of the arylsulfatase A ( ARSA ) enzyme, which leads to the accumulation of sulfatides (both galactosyl and lactosyl sulfatide) in the white matter of the central nervous system, the peripheral nervous system, and to a lesser extent, in visceral organs including the kidney and gallbladder. (testcatalog.org)
  • In some cases, individuals with very low arylsulfatase A activity show no signs or symptoms of metachromatic leukodystrophy. (nih.gov)
  • Metachromatic leukodystrophy (MLD) is a lysosomal storage disorder caused by a deficiency of the arylsulfatase A (ARSA) enzyme, which leads to the accumulation of galactosyl sulfatide (cerebroside sulfate) in the white matter of the central nervous system and in the peripheral nervous system. (testcatalog.org)
  • Metachromatic leukodystrophy (MLD) occurs when an enzyme known as arylsulfatase A (ARSA) isn't present in the body. (healthline.com)
  • Arylsulfatase A (ASA) is a lysosomal enzyme involved in catabolism of cerebroside sulfate, whose deficiency causes metachromatic leukodystrophy, a rare autosomal recessive disorder characterized by storage of cerebroside sulfate, mainly in the nervous system. (cdc.gov)
  • Metachromatic leukodystrophy (MLD) is an inherited, autosomal recessive disorder of lipid metabolism characterized by deficient activity of the lysosomal enzyme, arylsulfatase A (ASA). (clinicaltrials.gov)
  • A marked deficiency of arylsulfatase A, which is considered the heat-labile component of cerebroside sulfatase, has been demonstrated in all forms of metachromatic leukodystrophy (LEUKODYSTROPHY, METACHROMATIC). (nih.gov)
  • Although arylsulfatase A pseudodeficiency is characterized as a disease, about 1-2% of any population of clinically healthy people have two copies of "the" ARSA pseudodeficiency allele, identified by rs6151429 . (snpedia.com)
  • This does lead to low levels of arylsulfatase (ARSA). (snpedia.com)
  • MLD is a neurodegenerative disease caused by lysosomal arylsulfatase enzyme deficiency due to ARSA gene mutations. (thefreedictionary.com)
  • ARSA (Arylsulfatase A) is a Protein Coding gene. (genecards.org)
  • The ARSA gene provides instructions for making the enzyme arylsulfatase A. This enzyme is located in cellular structures called lysosomes, which are the cell's recycling centers. (nih.gov)
  • Arylsulfatase B (ARSB) can be measured with nitrocatechol sulfate as the substrate. (mayomedicallaboratories.com)
  • The conditions established are such that arylsulfatase A activity is minimal and its residual activity can be accounted for and subtracted from the activity of ARSB. (mayomedicallaboratories.com)
  • We offer Arylsulfatase B/ARSB Peptides and Arylsulfatase B/ARSB Proteins for use in common research applications: Blocking/Neutralizing, Control, ELISA, Protein Array, Western Blot. (novusbio.com)
  • Each Arylsulfatase B/ARSB Peptide and Arylsulfatase B/ARSB Protein is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. (novusbio.com)
  • Our Arylsulfatase B/ARSB Peptides and Arylsulfatase B/ARSB Proteins can be used in a variety of model species: Human. (novusbio.com)
  • Choose from our Arylsulfatase B/ARSB Peptides and Proteins. (novusbio.com)
  • 90 Arylsulfatase B (ARSB) Antibodies from 19 manufacturers are available on www.antibodies-online.com. (antibodies-online.com)
  • BACKGROUND:Arylsulfatase B (ARSB) removes the 4-sulfate group from chondroitin 4-sulfate (C4S) and dermatan sulfate and is required for their degradation. (iospress.com)
  • Mucopolysaccharidosis type VI can be screened by measuring the lysosomal arylsulfatase B (ARSB) residual enzyme activity in dried blood spots (DBS) using synthetic substrates. (sigmaaldrich.com)
  • Our aim was to improve RGC regeneration after optic nerve crush (ONC) in adult mice by combining an intrinsic stimulus (intravitreal zymosan) with the enzyme arylsulfatase B (ARSB), which cleaves axon-inhibiting sulfate groups from chondroitin sulfate proteoglycans (CSPGs) in the extracellular matrix. (arvojournals.org)
  • Novel mutations of the arylsulphatase B (ARSB) gene in Indian patients with mucopolysaccharidosis type VI. (nih.gov)
  • Overall SP600125 manufacturer pattern of arylsulfatase B (ARSB) staining in normal, villous adenomas, and adenocarcinomas. (researchatlanta.org)
  • Luminal membrane staining of arylsulfatase B (ARSB). (researchatlanta.org)
  • Arylsulfatase D antibody LS-C156519 is an unconjugated rabbit polyclonal antibody to human Arylsulfatase D (ARSD) (aa502-532). (lsbio.com)
  • We propose that a contributing mechanism for the neurological damage is that lead induces critically low levels of arylsulfatase A (ASA) at sensitive stages of nervous system development. (researchwithrutgers.com)
  • These mutations greatly reduce the activity of arylsulfatase A. Severe disruption in arylsulfatase A activity interferes with the breakdown of sulfatides. (nih.gov)
  • Frequency of arylsulphatase A pseudodeficiency associated mutations in a healthy population. (ox.ac.uk)
  • Croatian population data for arylsulfatase a pseudodeficiency-associated mutations in healthy subjects, and in patients with Alzheimer-type dementi. (cdc.gov)
  • Arylsulfatase E is a member of the arylsulfatase subfamily of sulfatase enzymes that catalyze the hydrolysis of sulfate esters. (wikipedia.org)
  • To gain insights into the molecular determinants of adaptation in promiscuous enzymes, we performed the laboratory evolution of an arylsulfatase to improve its initially weak phenylphosphonate hydrolase activity. (rcsb.org)
  • Phosphorylation of oligosaccharides of the lysosomal enzyme arylsulphatase A (ASA), which accumulate in the secretions of cells that mis-sort most of the newly synthesized lysosomal enzymes due to a deficiency of mannose 6-phosphate receptors, was found to be site specific. (biochemj.org)
  • Arylsulfatase A and B activities were assayed in leucocytes of 43 controls, 11 cases of Metachromatic Leucodystrophy and 7 parents or siblings of patients, using a new technique implying specific inhibitors for leucocyte enzymes. (meta.org)
  • HAH_1665, annotated as a polysaccharide biosynthesis protein, and HAH_1666, annotated as an arylsulfatase A family protein, might all together participate in the synthesis of the acidic EPS (Figure S1A available online at https://doi.org/10.1155/2017/5842958). (thefreedictionary.com)
  • The arylsulfatase activity, detectable 3 h after the transfer of the cells to low sulfate medium (less than or equal to 10 microM sulfate), is a periplasmic protein released into the culture medium by cw15, a cell wall-less mutant of C. reinhardtii. (rupress.org)
  • This protein displays arylsulfatase activity at acidic pH, as is typical of lysosomal sulfatases, and has been shown to localize in the lysosomes. (nih.gov)
  • Case of a Mongolian child with extensive Mongolian spots in mucopolysaccharidosis type VI: identification of a novel mutation in the arylsulfatase B gene. (nih.gov)
  • Isolation and characterization of the pig endometrial arylsulphatase A. (biochemj.org)
  • Types include: Arylsulfatase A (also known as "cerebroside-sulfatase") Arylsulfatase B (also known as "N-Acetylgalactosamine-4-Sulfatase") Steroid sulfatase (formerly known as "Arylsulfatase C") ARSC2 ARSD ARSE ARSF ARSG ARSH ARSI ARSJ ARSK Aryl Dodgson KS, Spencer B, Williams K (October 1956). (wikipedia.org)
  • Arylsulfatase E, also known as ARSE, is an enzyme that, in humans, is encoded by the ARSE gene. (wikipedia.org)
  • Presence of a lysosomal enzyme, arylsulfatase-A, in the prelysosome-endosome compartments of human cultured fibroblasts. (mcmaster.ca)
  • Steroid sulfatase and arylsulfatase C activities in leukocytes and fibroblasts were markedly diminished in the affected patients. (wustl.edu)
  • 12) The organism has positive reactions for two-week arylsulfatase test, pyrazinamidase, growth on T2H, 10-day tween hydrolysis test, and urease. (thefreedictionary.com)
  • Immunohistochemical analysis of Arylsulfatase A staining in human brain formalin fixed paraffin embedded tissue section. (acris-antibodies.com)
  • Waalkes, T. P. / Separation and analysis of arylsulfatase isoenzymes in body fluids of man . (elsevier.com)
  • We have purified the derepressible arylsulfatase to homogeneity and have raised monospecific antibodies to it. (rupress.org)
  • In addition, concentrations of acid phosphatase and arylsulfatase in surface sediments were significantly correlated with the prominent bacterial amoA genotypes, and concentrations of TOC and urease were found to be significantly correlated with the prominent archaeal amoA genotype compositions. (frontiersin.org)
  • Clinical features suggestive of Keutel syndrome were also observed in one additional unrelated patient who was later found to have a deletion of arylsulfatase E, consistent with a diagnosis of X-linked recessive chondrodysplasia punctata. (medeniyet.edu.tr)
  • The pig endometrial arylsulphatase A was purified 3322-fold to a specific activity of 150 mumol/min per mg. (biochemj.org)
  • Improving arylsulfatase activity determination in dried blood spots: Screening and diagnostic approaches for Maroteaux-Lamy syndrome (MPS VI). (sigmaaldrich.com)
  • The nuclear membrane showed strong arylsulfatase activity as well as rough endoplasmic reticulum and lysosomes. (americanelements.com)
  • These cells showed a deficiency in arylsulfatase B activity. (sciencemag.org)
  • A first biomarker study sponsored by Inventiva showed that, despite ERT treatment, the current standard of care, leukoGAG levels remained very high and were not impacted when measured one hour after ERT infusion although the activity of the arylsulfatase B[sup.2] enzyme was very high. (thefreedictionary.com)
  • Arylsulfatase activity, which is partly responsible for S cycling in soils [20], was chosen as a representative S-acquiring enzyme and was determined with p-nitrophenyl sulfate as the substrate in an acetate buffer at pH 5.8 [20]. (thefreedictionary.com)
  • A homozygous founder missense variant in arylsulfatase G abolishes its enzymatic activity causing atypical Usher syndrome in humans. (uni-bielefeld.de)
  • Background: Mucopolysaccharidosis type-VI (MPS-VI), which is inherited as an autosomal recessive trait, results from the deficiency of N-acetylgalactosamine 4-sulfatase (arylsulfatase B) activity and the lysosomal accumulation of dermatan sulfate. (ac.ir)
  • Displays arylsulfatase activity at acidic pH with pseudosubstrates, such as p-nitrocatechol sulfate and also, but with lower activity, p-nitrophenyl sulfate and 4-methylumbelliferyl sulfate. (nih.gov)
  • The potential of rapid, chromatographic separation coupled with continuous monitoring for arylsulfatase activity is discussed. (elsevier.com)
  • Biochemical confirmation is made by reduced activity of both arylsulfatase A and B. (testcatalog.org)
  • GO annotations related to this gene include calcium ion binding and arylsulfatase activity . (genecards.org)
  • Assays of arylsulfatase activity in psychotic patients. (meta.org)
  • The aim of the study was to investigate the effect of varying rates of FYM (0, 20, 40, 60 Mg ha -1 ) and nitrogen N 0 , N 1 , N 2 , and N 3 on the content of sulphate sulphur (VI) and the activity of arylsulphatase, which participates in the transformations of this element in Haplic Luvisol. (international-agrophysics.org)
  • The FYM fertilization rate for which the highest arylsulphatase activity and the content of sulphates were identified was 60 Mg ha -1 . (international-agrophysics.org)
  • An inhibitory effect of high rates (90 and 135 kg N ha -1 ) of ammonium nitrate on the arylsulphatase activity was also observed. (international-agrophysics.org)
  • A significant correlation between the content of carbon, nitrogen, and sulphates and the arylsulphatase activity was recorded. (international-agrophysics.org)
  • The investigation on the effect of combined application of farmyard manure and mineral nitrogen fertilization on the activity of arylsulphatase participating in the sulphur cycling was launched to examine the problem in detail. (international-agrophysics.org)
  • Arylsulfatase A activity was measured in leukocyte homogenates by spectrophotometry (lambda = 515 nm) using p-nitrocatechol sulfate as chromogenic substrate. (cdc.gov)
  • Arylsulfatase A activity was slightly but not significantly decreased in leukocytes derived from subjects with dementia and Down syndrome in comparison with age-matched control samples. (cdc.gov)
  • The objective of this study was to evaluate the enzymatic activity of acid and alkaline phosphatases, urea and arylsulfatase in the superficial layers of soils in areas under different stages of forest regeneration, in Floresta-PE City. (scielo.br)
  • Soluble arylsulfatase (EC 3.1.6.1) is present in the body fluids of man in the form of two isoenzymes, arylsulfatase A and B, which reportedly are useful biochemical markers for certain types of malignancy. (elsevier.com)
  • We used a new mouse model of mucopolysaccharidosis IIIE to study the effect of Arylsulfatase G (ARSG) deficiency on retina integrity. (uni-bielefeld.de)
  • Arylsulfatase G (ARSG) is a recently identified lysosomal sulfatase that was shown to be responsible for the degradation of 3-O-sulfated N-sulfoglucosamine residues of heparan sulfate glycosaminoglycans. (uni-bielefeld.de)
  • Accumulation of rare variants in the arylsulfatase G (ARSG) gene in task-specific dystonia. (cdc.gov)
  • Arylsulfatase A is also deficient in individuals with multiple sulfatase deficiency. (uiowa.edu)
  • This disorder is distinct from conditions caused by deficiencies of arylsulfatase B (Maroteaux-Lamy disease) and arylsulfatase C (steroid sulfatase deficiency). (uiowa.edu)
  • Pseudomonas aeruginosa arylsulfatase (PAS) is a bacterial sulfatase capable ofhydrolyzing a range of sulfate esters. (diva-portal.org)
  • sulfatase (2) , arylsulphatase . (thefreedictionary.com)
  • Arylsulfatase B encoded by this gene belongs to the sulfatase family. (nih.gov)
  • Arylsulfatase B (N-acetylgalactosamine-4-sulfatase): potential role as a biomarker in prostate cancer. (nih.gov)
  • Individuals with multiple sulfatase deficiency, which is clinically distinct from MLD, will also have deficiency of arylsulfatase A. (testcatalog.org)
  • called arylsulfatase A (ASA), or cerebroside sulfatase . (britannica.com)
  • Fingerprint Dive into the research topics of 'A new syndrome of anosmia, ichthyosis, hypogonadism, and various neurological manifestations with deficiency of steroid sulfatase and arylsulfatase C'. Together they form a unique fingerprint. (wustl.edu)
  • Increased expression of colonic Wnt9A through Sp1-mediated transcriptional effects involving arylsulfatase B, chondroitin 4-sulfate, and galectin-3. (nih.gov)
  • Kruszewski K, Luellmann-Rauch R, Dierks T, Bartsch U, Damme M. Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice. (uni-bielefeld.de)
  • Degeneration of Photoreceptor Cells in Arylsulfatase G-Deficient Mice", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE , vol. 57, 2016, pp. 1120-1131. (uni-bielefeld.de)
  • Arylsulfatase B should always be measured if ASA is deficient. (testcatalog.org)
  • Wilson's disease with Leu492Ser mutation and arylsulfatase A pseudodeficiency: just a coincidence? (springer.com)
  • Here we report a new case of WD in which a rare mutation, Leu492Ser expressed for the first time in homozygosity, is associated with neurological presentation of the disease and arylsulfatase A pseudeficiency. (springer.com)
  • Additionally, despite the proposed role of arylsulfatase A pseudodeficiency as one of the predisposing factors for neuropsychiatric disorders, our preliminary results did not show significantly higher frequencies of either mutation in Alzheimer-type dementia or Down syndrome. (cdc.gov)
  • Arylsulphatase A (ASA, EC 3.1.6.1) is a lysosomal enzyme that catalyses cerebroside sulphate degradation. (ox.ac.uk)
  • Arylsulfatase A (ASA) is a lysosomal enzyme involved in the catabolism of cerebroside sulfate. (archives-ouvertes.fr)
  • Genome-wide association study in musician's dystonia: a risk variant at the arylsulfatase G locus? (cdc.gov)
  • The acid and alkaline phosphatase, arylsulfatase and urease increased with time of regeneration. (scielo.br)
  • Mucopolysaccharidosis type VI is an autosomal recessive lysosomal storage disorder resulting from a deficiency of arylsulfatase B. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. (nih.gov)
  • Arylsulfatase B test is a blood test performed in children to diagnose an inherited disorder known as Maroteaux-Lamy syndrome, or mucopolysaccharidosis VI. (nicklauschildrens.org)
  • Spectrophotometric enzyme assay using p-nitrocatechol sulfate as substrate with inhibition of Arylsulfatase B by NaCl and cold temperature incubation. (testcatalog.org)
  • Your search returned 129 Arylsulfatase A ELISA ELISA Kit across 17 suppliers. (biocompare.com)
  • Your search returned 13 arylsulfatase family member I ELISA ELISA Kit across 1 supplier. (biocompare.com)
  • Baum H, Dodgson KS, Spencer B: Assay of arylsulfatases A and B in human urine. (mayomedicallaboratories.com)
  • The antiserum was produced against synthesized peptide derived from human Arylsulfatase D. (genetex.com)
  • Human arylsulfatase B produced by recombinant DNA technology in Chinese hamster ovary cells. (druglead.com)
  • Results from this assay may not reflect carrier status because of individual variation of arylsulfatase A enzyme levels. (umich.edu)
  • Since translatable RNA encoding the arylsulfatase can only be detected in cells after sulfate starvation, it is likely that accumulation of the enzyme is regulated at the level of transcription, although posttranscriptional processes may also be involved. (rupress.org)
  • Degradation of arylsulfatase A in the endoplasmic reticulum. (nih.gov)
  • Among its related pathways are Gamma carboxylation, hypusine formation and arylsulfatase activation and Metabolism . (genecards.org)
  • Spatial patterns of arylsulfatase mRNA expression in sea urchin embryo. (nii.ac.jp)
  • Within lysosomes, arylsulfatase A helps process substances known as sulfatides. (nih.gov)
  • Purification and biosynthesis of a derepressible periplasmic arylsulfatase from Chlamydomonas reinhardtii. (rupress.org)
  • Studies focused on arylsulfatase biosynthesis demonstrate that it is glycosylated and synthesized as a higher molecular mass precursor. (rupress.org)
  • The arylsulfatase B homodimer hydrolyzes sulfate groups of N-Acetyl-D-galactosamine, chondriotin sulfate, and dermatan sulfate. (nih.gov)