An enzyme which catalyzes the hydrolysis of an aryl-dialkyl phosphate to form dialkyl phosphate and an aryl alcohol. It can hydrolyze a broad spectrum of organophosphate substrates and a number of aromatic carboxylic acid esters. It may also mediate an enzymatic protection of LOW DENSITY LIPOPROTEINS against oxidative modification and the consequent series of events leading to ATHEROMA formation. The enzyme was previously regarded to be identical with Arylesterase (EC 3.1.1.2).
A class of enzymes that catalyze the hydrolysis of one of the three ester bonds in a phosphotriester-containing compound.
A highly toxic cholinesterase inhibitor that is used as an acaricide and as an insecticide.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A genus of gram-negative, aerobic, rod-shaped bacteria widely distributed in SOIL and WATER. Its organisms are also found in raw meats, MILK and other FOOD, hospital environments, and human clinical specimens. Some species are pathogenic in humans.
Pesticides designed to control insects that are harmful to man. The insects may be directly harmful, as those acting as disease vectors, or indirectly harmful, as destroyers of crops, food products, or textile fabrics.
The methyl homolog of parathion. An effective, but highly toxic, organothiophosphate insecticide and cholinesterase inhibitor.
Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.
An organophosphate cholinesterase inhibitor that is used as a pesticide.
Poisoning due to exposure to ORGANOPHOSPHORUS COMPOUNDS, such as ORGANOPHOSPHATES; ORGANOTHIOPHOSPHATES; and ORGANOTHIOPHOSPHONATES.
A medical specialty primarily concerned with prevention of disease (PRIMARY PREVENTION) and the promotion and preservation of health in the individual.
Cyclic esters of hydroxy carboxylic acids, containing a 1-oxacycloalkan-2-one structure. Large cyclic lactones of over a dozen atoms are MACROLIDES.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
A plant genus of the family LINACEAE that is cultivated for its fiber (manufactured into linen cloth). It contains a trypsin inhibitor and the seed is the source of LINSEED OIL.
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Products in capsule, tablet or liquid form that provide dietary ingredients, and that are intended to be taken by mouth to increase the intake of nutrients. Dietary supplements can include macronutrients, such as proteins, carbohydrates, and fats; and/or MICRONUTRIENTS, such as VITAMINS; MINERALS; and PHYTOCHEMICALS.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Eighteen-carbon essential fatty acids that contain three double bonds.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
A regimen or plan of physical activities designed and prescribed for specific therapeutic goals. Its purpose is to restore normal musculoskeletal function or to reduce pain caused by diseases or injuries.
Organic or inorganic compounds that contain the -N3 group.
Toxins closely associated with the living cytoplasm or cell wall of certain microorganisms, which do not readily diffuse into the culture medium, but are released upon lysis of the cells.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)
Sensitive method for detection of bacterial endotoxins and endotoxin-like substances that depends on the in vitro gelation of Limulus amebocyte lysate (LAL), prepared from the circulating blood (amebocytes) of the horseshoe crab, by the endotoxin or related compound. Used for detection of endotoxin in body fluids and parenteral pharmaceuticals.
Proteins obtained from ESCHERICHIA COLI.
An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.
An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.
Conditions with abnormally low levels of LIPOPROTEINS in the blood. This may involve any of the lipoprotein subclasses, including ALPHA-LIPOPROTEINS (high-density lipoproteins); BETA-LIPOPROTEINS (low-density lipoproteins); and PREBETA-LIPOPROTEINS (very-low-density lipoproteins).
Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.
An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.
A group of compounds that has the general structure of a dicarboxylic acid-substituted benzene ring. The ortho-isomer is used in dye manufacture. (Dorland, 28th ed)
An infectious dermatitis of sheep and goats, affecting primarily the muzzle and lips. It is caused by a poxvirus and may be transmitted to man.
The type species of PARAPOXVIRUS which causes a skin infection in natural hosts, usually young sheep. Humans may contract local skin lesions by contact. The virus apparently persists in soil.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Dissertations embodying results of original research and especially substantiating a specific view, e.g., substantial papers written by candidates for an academic degree under the individual direction of a professor or papers written by undergraduates desirous of achieving honors or distinction.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Organic matter in a state of advanced decay, after passing through the stages of COMPOST and PEAT and before becoming lignite (COAL). It is composed of a heterogenous mixture of compounds including phenolic radicals and acids that polymerize and are not easily separated nor analyzed. (E.A. Ghabbour & G. Davies, eds. Humic Substances, 2001).
Large aggregates of CELESTIAL STARS; COSMIC DUST; and gas. (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed)
An antiseptic and disinfectant aromatic alcohol.
A frozen dairy food made from cream or butterfat, milk, sugar, and flavorings. Frozen custard and French-type ice creams also contain eggs.
Large bodies consisting of self-luminous gas held together by their own gravity. (From McGraw Hill Dictionary of Scientific and Technical Terms, 6th ed)
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.

Isolation and complete covalent structure of liver microsomal paraoxonase. (1/676)

Paraoxonase (PON1) is a serum esterase exclusively associated with high-density lipoproteins; it might confer protection against coronary artery disease by destroying pro-inflammatory oxidized lipids in oxidized low-density lipoproteins. Here I show that rabbit liver microsomes contain a PON analogue (MsPON) and report the isolation and complete covalent structure of MsPON. In detergent-solubilized microsomes, MsPON co-purifies with the microsomal triacylglycerol transfer protein (MTP) complex. MsPON was separated from the complex and purified to homogeneity under non-denaturing conditions. Automated sequence analysis of intact MsPON and peptides obtained from enzymic and chemical cleavages led to the elucidation of the complete covalent structure of MsPON. The protein is a single polypeptide consisting of 350 residues. The sequence of rabbit liver microsomal MsPON is 60% identical with that of rabbit serum PON1, and 84% identical with the sequence predicted by a human cDNA of unknown function, designated PON3. MsPON has a hydrophobic segment at the N-terminus that might serve to anchor the protein to the microsomal membrane or to the MTP complex. Unlike in the serum enzyme, two potential N-glycan acceptor sites in MsPON are not glycosylated. An absence of N-glycans was also indicated in the rabbit liver MTP. MsPON has a single free cysteine residue at position 38 and a disulphide bond between Cys-279 and Cys-348. The microsomal enzyme lacks three residues at the N-terminus that are present in the serum protein. MsPON lacks four residues at the C-terminus that are present in the rabbit serum protein but absent from human serum PON1. On the basis of the observation that MsPON displays a high degree of similarity with serum PON1, it is proposed that MsPON might have a function related to that of PON1 in serum high-density lipoprotein complexes.  (+info)

Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor. (2/676)

A novel and potent azetidinone inhibitor of the lipoprotein-associated phospholipase A2 (Lp-PLA2), i.e. platelet-activating factor acetylhydrolase, is described for the first time. This inhibitor, SB-222657 (Ki=40+/-3 nM, kobs/[I]=6. 6x10(5) M-1.s-1), is inactive against paraoxonase, is a poor inhibitor of lecithin:cholesterol acyltransferase and has been used to investigate the role of Lp-PLA2 in the oxidative modification of lipoproteins. Although pretreatment with SB-222657 did not affect the kinetics of low-density lipoprotein (LDL) oxidation by Cu2+ or an azo free-radical generator as determined by assay of lipid hydroperoxides (LOOHs), conjugated dienes and thiobarbituric acid-reacting substances, in both cases it inhibited the elevation in lysophosphatidylcholine content. Moreover, the significantly increased monocyte chemoattractant activity found in a non-esterified fatty acid fraction from LDL oxidized by Cu2+ was also prevented by pretreatment with SB-222657, with an IC50 value of 5.0+/-0.4 nM. The less potent diastereoisomer of SB-222657, SB-223777 (Ki=6.3+/-0.5 microM, kobs/[I]=1.6x10(4) M-1.s-1), was found to be significantly less active in both assays. Thus, in addition to generating lysophosphatidylcholine, a known biologically active lipid, these results demonstrate that Lp-PLA2 is capable of generating oxidized non-esterified fatty acid moieties that are also bioactive. These findings are consistent with our proposal that Lp-PLA2 has a predominantly pro-inflammatory role in atherogenesis. Finally, similar studies have demonstrated that a different situation exists during the oxidation of high-density lipoprotein, with enzyme(s) other than Lp-PLA2 apparently being responsible for generating lysophosphatidylcholine.  (+info)

Paraoxonase 192 Gln/Arg gene polymorphism, coronary artery disease, and myocardial infarction in type 2 diabetes. (3/676)

Paraoxonase is an HDL-associated enzyme implicated in the pathogenesis of atherosclerosis by protecting lipoproteins against peroxidation. Its biallelic gene polymorphism at codon 192 (glutamine/arginine) has been associated with coronary artery disease (CAD). To further evaluate the role of this paraoxonase gene polymorphism for CAD in type 2 diabetes, we determined the paraoxonase genotype in 288 type 2 diabetic patients (170 with and 118 without angiographically documented CAD). The paraoxonase 192 Gln/Arg genotype was assessed using polymerase chain reaction followed by AlwI digestion. The frequency of the Gln allele was 0.656 in the CAD patients and 0.746 in the controls (chi2 = 5.36, P = 0.02). Compared with the Gln/Gln genotypes, the age-adjusted odds ratio for CAD was 1.78 (95% CI 1.08-2.96, P = 0.02) in subjects carrying at least one Arg allele. In the multivariate analysis, this association was even stronger after correction for the possible confounders age, sex, smoking history, and hypertension. Among current and former smokers, the odds ratio (OR) for having CAD among patients with at least one Arg allele was 3.58 (1.45-9.53, P < 0.01). The paraoxonase Arg allele was not associated with the history of myocardial infarction (OR 1.20 [0.73-1.99, NS]), but was with the extent of CAD (OR for three-vessel disease 1.92 [1.15-3.27, P = 0.01]). Our data indicate that the 192 Arg allele of the human paraoxonase gene is a risk factor for CAD but not myocardial infarction in type 2 diabetic patients, a risk factor further modified by cigarette smoking. This risk could possibly be explained by a reduced ability of the paraoxonase Arg isoform to protect lipoproteins against peroxidation.  (+info)

Role of group II secretory phospholipase A2 in atherosclerosis: 1. Increased atherogenesis and altered lipoproteins in transgenic mice expressing group IIa phospholipase A2. (4/676)

Some observations have suggested that the extracellular group IIa phospholipase A2 (sPLA2), previously implicated in chronic inflammatory conditions such as arthritis, may contribute to atherosclerosis. We have examined this hypothesis by studying transgenic mice expressing the human enzyme. Compared with nontransgenic littermates, the transgenic mice exhibited dramatically increased atherosclerotic lesions when maintained on a high-fat, high-cholesterol diet. Surprisingly, the transgenic mice also exhibited significant atherosclerotic lesions when maintained on a low-fat chow diet. Immunohistochemical staining indicated that sPLA2 was present in the atherosclerotic lesions of the transgenic mice. On both chow and atherogenic diets, the transgenic mice exhibited decreased levels of HDLs and slightly increased levels of LDLs compared with nontransgenic littermates. These data indicate that group IIa sPLA2 may promote atherogenesis, in part, through its effects on lipoprotein levels. These data also provide a possible mechanism for the observation that there is an increased incidence of coronary artery disease in many chronic inflammatory diseases.  (+info)

Role of group II secretory phospholipase A2 in atherosclerosis: 2. Potential involvement of biologically active oxidized phospholipids. (5/676)

Secretory nonpancreatic phospholipase A2 (group II sPLA2) is induced in inflammation and present in atherosclerotic lesions. In an accompanying publication we demonstrate that transgenic mice expressing group II sPLA2 developed severe atherosclerosis. The current study was undertaken to determine whether 1 mechanism by which group II sPLA2 might contribute to the progression of inflammation and atherosclerosis is by increasing the formation of biologically active oxidized phospholipids. In vivo measurements of bioactive lipids were performed, and in vitro studies tested the hypothesis that sPLA2 can increase the accumulation of bioactive phospholipids. We have shown previously that 3 oxidized phospholipids derived from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (PAPC) stimulated endothelial cells to bind monocytes, a process that is known to be an important step in atherogenesis. We now show that these 3 biologically active phospholipids are significantly increased in livers of sPLA2 transgenic mice fed a high-fat diet as compared with nontransgenic littermates. We present in vitro evidence for several mechanisms by which these phospholipids may be increased in sPLA2 transgenics. These studies demonstrated that polyunsaturated free fatty acids, which are liberated by sPLA2, increased the formation of bioactive phospholipids in LDL, resulting in increased ability to stimulate monocyte-endothelial interactions. Moreover, sPLA2-treated LDL was oxidized by cocultures of human aortic endothelial cells and smooth muscle cells more efficiently than untreated LDL. Analysis by electrospray ionization-mass spectrometry revealed that the bioactive phospholipids, compared with unoxidized PAPC, were less susceptible to hydrolysis by human recombinant group II sPLA2. In addition, HDL from the transgenic mice and human HDL treated with recombinant sPLA2 in vitro failed, in the coculture system, to protect against the formation of biologically active phospholipids in LDL. This lack of protection may in part relate to the decreased levels of paraoxonase seen in the HDL isolated from the transgenic animals. Taken together, these studies show that levels of biologically active oxidized phospholipids are increased in sPLA2 transgenic mice; they also suggest that this increase may be mediated by effects of sPLA2 on both LDL and HDL.  (+info)

Reduced postprandial serum paraoxonase activity after a meal rich in used cooking fat. (6/676)

Paraoxonase is an enzyme associated with HDL in human serum that hydrolyzes oxidized phospholipids and inhibits LDL oxidation, which is an important step in atherogenesis. In animals, addition of oxidized lipids to the circulation reduces paraoxonase activity, and diets rich in oxidized fat accelerate the development of atherosclerosis. The current randomized, crossover study was designed to compare the effect of a meal rich in oxidized lipids in the form of fat that had been used for deep-frying in a fast food restaurant and a control meal rich in the corresponding unused fat on postprandial serum paraoxonase (arylesterase) activity and peroxide content of LDL and its susceptibility to copper ion catalyzed oxidation in 12 healthy men. Four hours into the postprandial period, serum paraoxonase activity had decreased significantly after the used fat meal (-17%, P=0.005) and had increased significantly after the meal rich in unused fat (14%, P=0. 005). These changes were significantly (P=0.003) different. A time-course study indicated that serum paraoxonase activity remained lower than baseline for up to 8 hours after the used fat meal. Serum apoA1 concentration tended to decrease after the unused fat meal and tended to increase after the used fat meal. These changes were different at a marginal level of significance (P=0.07). Also, a significantly (P=0.03) greater decrease in apoA1 content of postprandial HDL was recorded after the unused fat meal. The peroxide content of LDL tended to decrease after the used fat meal and tended to increase after the control meal. These changes were significantly (P=0.04) different. Susceptibility of isolated LDL to copper ion oxidation and plasma levels of malondialdehyde were unchanged during the study. These data suggest that in the postprandial period after a meal rich in used cooking fat, the enzymatic protection of LDL against accumulation of peroxides and atherogenic oxidative modification may be reduced, possibly due to factors associated with apoA1, without acutely affecting the intrinsic resistance of LDL to in vitro oxidation.  (+info)

Gln --> Arg 191 polymorphism of paraoxonase and Parkinson's disease. (7/676)

We investigated the Gln --> Arg 191 polymorphism in paraoxonase (PON1) in St. Petersburg population, in three clinically differentiated groups of patients with Parkinson's disease (PD) and in the symptomatic tremor group. A new approach for Gln --> Arg 191 PON1 polymorphism genotyping is suggested. No significant differences in the groups studies as compared to the controls was observed.  (+info)

Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. (8/676)

Lecithin:cholesteryl acyltransferase (LCAT) deficiency resulting from targeted disruption of the Lcat gene in the mouse is associated with dramatic decreases in HDL concentration and the accumulation of nascent HDL in the plasma. We examined whether LCAT deficiency in mice is associated with a concomitant decrease in two antioxidative enzymes, paraoxonase (PON) and platelet-activating factor acetylhydrolase (PAF-AH). In control Lcat (+/+) mice both these enzymes are transported on HDL. Compared to Lcat (+/+) mice, HDL-cholesterol is reduced 94% and apoA-I, 90%, in Lcat (-/-) mice; this reduction in HDL is paralleled by a 71% decrease in PAF-AH activity and in a 58% decrease in PON activity. Apolipoprotein J (apoJ) levels, rather than being decreased, were significantly (P = 0.01) higher (36%) in Lcat (-/-) than in Lcat (+/+) mice, and the apo J/PON ratio was 3-fold greater in Lcat (-/-) than in Lcat (+/+) animals. Even though apolipoprotein A-I (apoA-I) concentration and PON activity were drastically reduced, there was no reduction in apoA-I and PON liver mRNA levels suggesting that post-transcriptional events are responsible for the reduction of plasma PON and apoA-I levels. Fast protein liquid chromatography (FPLC) revealed that in Lcat (+/+) mice both PON and PAF-AH activity is associated with large, apoA-I-containing HDL particles (9.7 nm by non-denaturing gradient gel electrophoresis) while in Lcat (-/-) mice both enzymes are associated with small 8.2 nm particles. We conclude that the concomitant reduction in HDL and apoA-I concentrations and PON and PAF-AH activities is best explained by rapid clearance of the small HDL particles found in LCAT deficiency.  (+info)

TY - JOUR. T1 - A common mutation in paraoxonase-2 results in impaired lactonase activity. AU - Stoltz, David A.. AU - Ozer, Egon A.. AU - Recker, Thomas J.. AU - Estin, Miriam. AU - Yang, Xia. AU - Shih, Diana M.. AU - Lusis, Aldons J.. AU - Zabner, Joseph. PY - 2009/12/18. Y1 - 2009/12/18. N2 - Paraoxonases (PONs) are a family of lactonases with promiscuous enzyme activity that has been implicated in multiple diseases. PON2 is intracellularly located, is the most ubiquitously expressed PON, and has the highest lactonase activity of the PON family members. Whereas some single-nucleotide polymorphisms (SNPs) in PON1 have resulted in altered enzymatic activity in serum, to date the functional consequences of SNPs on PON2 function remain unknown. We hypothesized that a common PON2 SNP would result in impaired lactonase activity. Substitution of cysteine for serine at codon 311 in recombinant PON2 resulted in normal protein production and localization but altered glycosylation and decreased ...
BACKGROUND: Although there have been suggestions that serum paraoxonase is important in protecting against coronary heart disease (CHD), a large number of studies of genetic determinants of serum paraoxonase have reported apparently conflicting results about their association with CHD. METHODS: We conducted a meta-analysis of 43 studies of the Q192R, L55M, and T(-107)C polymorphisms in the paraoxonase PON1 gene and the S311C polymorphism in the PON2 gene (all of which are in moderately strong linkage disequilibrium with one another), involving a total of 11212 CHD cases and 12786 controls. We explored potential sources of heterogeneity. FINDINGS: In a combined analysis of all studies, the per-allele relative risk of R192 for CHD was 1.12 (95% CI 1.07-1.16), but in the five largest studies it was only 1.05 (0.98-1.13). Combined analyses of studies of the M55, (-107)T, and C311 variants showed no significant overall associations with CHD, yielding per-allele relative risks of 1.00 (0.95-1.06), 1.02 (0.92
Objective High-density lipoprotein cholesterol (HDL-C) levels are inversely related to the risk of coronary artery disease (CAD). Alterations in HDL-C subclass distribution and HDL-associated enzyme activities may be more important than total HDL levels for the progression of CAD. We intended to investigate the relationship of HDL-C subclass distribution and HDL-associated enzyme activities with CAD. ...
Paraoxonase/arylesterase is a serum enzyme that is associated with HDL particles. It hydrolyzes the toxic oxons of several organophosphorus insecticides and the...
Serum paraoxonase/arylesterase 1 (PON1) also known as A esterase , homocysteine thiolactonase or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. Paraoxonase 1 has esterase and more specifically paraoxonase activity. Serum PON1 is found in all mammalian species studied so far but is not present in the serum of birds, fish and reptiles or in insects. PON1 is the first discovered member of a multigene family also containing PON2 and PON3, the genes for which are located adjacent to each other on chromosome 7. Human PON1 is a glycoprotein composed of 354 amino acids and has a molecular weight of 43000 Daltons which associates with high-density lipoprotein (HDL, good cholesterol) in the circulation. Serum PON1 is secreted mainly by the liver although local synthesis occurs in several tissues and PON1 protein is found in almost all tissues. X-ray crystallography has revealed the structure of PON1 to be a 6 bladed propeller with a unique lid structure covering ...
Paper:Serum paraoxonase-1 as biomarker for improved diagnosis of fatty liver in dairy cows. , Author:Ayman Samir Farid, Kazuyuki Honkawa, Eman Mohamed Fath, Nariaki Nonaka, and Yoichiro Horii , Year:2013 , Faculty of Veterinary Medicine ,Department of Clinical Pathology ,Benha University
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification.
Sigma-Aldrich offers abstracts and full-text articles by [M Aviram, M Rosenblat, S Billecke, J Erogul, R Sorenson, C L Bisgaier, R S Newton, B La Du].
Human serum paraoxonase/arylesterase 1 (PON1) standard, for use in running standard curves in AlphaLISA detection and quantitation assays
Background: High-density lipoprotein (HDL) cholesterol is well-established as a negative risk factor for coronary artery disease. Its antioxidant properties are attributed mainly to the HDL-bound enzyme, paraoxonase-1 (PON-1). Recently, myeloperoxidase (MPO) has been shown to attenuate the atheroprotective function of HDL. This study investigated the relationship between plasma MPO and serum PON-1 levels in patients with stable angina pectoris (SAP), and whether PON-1 levels predict cardiovascular events in SAP patients after stent implantation.. Methods: Plasma MPO levels and serum PON-1 concentration and activity were measured in patients with SAP (n=226) and in control subjects (n=96). In addition, we assessed the prognostic significance of serum PON-1 concentrations on admission after stent implantation in 263 SAP patients. Cardiac events were defined as sudden cardiac death, fatal or non-fatal myocardial infarction and other non-fatal events including unstable angina pectoris or coronary ...
Paraoxonases are a family of mammalian enzymes with aryldialkylphosphatase activity. There are three paraoxonase isozymes, which were originally discovered for their involvement in the hydrolysis of organophosphates. Research has indicated the enzymatic activity of paraoxonases is more diversified than its activity as an organophosphatase. Esterase and lactonase activity has also been observed from these enzymes and though the physiologically relevant substrates for these enzymes are unknown, it is likely that lactones are the main substrate (although there is a relatively high level of variation in substrate specificity among these enzymes). Most of the studies on the paraoxonase family have specifically looked at the paraoxonase 1 type, leaving much to be learned about the remaining two. The study of this enzyme family has many potential consequences in preventative medicine and toxicology as well as in certain societal contexts. The genes that encode for these enzymes have a number of ...
TY - JOUR. T1 - Association between the paraoxonase-1 192Q,R allelic variant and coronary endothelial dysfunction in patients with early coronary artery disease. AU - Lavi, Shahar. AU - McConnell, Joseph P.. AU - Lavi, Ronit. AU - Barsness, Gregory W.. AU - Rihal, Charanjit S.. AU - Novak, Gregory D.. AU - Lerman, Lilach O. AU - Lerman, Amir. PY - 2008. Y1 - 2008. N2 - OBJECTIVE: To test the hypothesis that allelic variants of the paraoxonase-1 gene are associated with endothelial dysfunction, an early stage of atherosclerosis. PATIENTS AND METHODS: We assessed 192Q,R and 55L,M allelic variants of the paraoxonase gene and coronary endothelial function in response to intracoronary acetylcholine in 99 patients (52 with homozygous QQ, 47 with homozygous RR or heterozygous QR). The study was conducted from September 1, 2002, through November 30, 2004. RESULTS: Of 52 homozygous QQ patients, 39 (75%) had endothelial dysfunction vs 20 (43%) of the 47 RR/QR patients (P=.001), and this association ...
Recombinant Human PON1 protein (BSA and azide free) is an Escherichia coli Full length protein 1 to 355 aa range, | 90% purity, | 1.000 Eu/µg endotoxin level and validated in WB, ELISA…
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In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group ...
Three paraoxonase genes (PON 1, PON 2, PON 3) have been mapped to chromosome 7 and a number of polymorphisms have been identified.32 PON prevents lipid peroxidation of LDLs and PON 1 has been shown to hydrolyze lipid peroxides in human atherosclerotic lesions.32 Oxidative modification of LDL cholesterol renders it particularly atherogenic, making identification of factors protecting against oxidative modification potentially important in the prevention of atherosclerosis.117 Two frequent PON 1 polymorphisms at positions 192 (glutamine to arginine) and 55 (methionine to leucine) are in linkage disequilibrium and are associated with variations in PON activity to different substrates.117 Associations between PON 1 and PON 2 polymorphisms and a variety of CVD phenotypes, however, have been inconsistent,32 with some studies showing the 55L allele and/or the 192R allele to be associated with increased risk118 and others showing no association.32 Both cigarette smoking and diabetes are associated with ...
The molecular bases underlying the alterations in the circulating PON1 activity together with its synthesis and secretion in chronic liver diseases are far from being completely understood, despite these changes being of crucial importance in the pathophysiology of chronic liver impairment. As illustrated in the present investigation, patients with liver cirrhosis had an increased serum concentration of total peroxides (a marker of oxidative stress), MCP-1 (an index of inflammation), and P-III-P (a marker of liver fibrogenesis). All these changes were observed to be strongly associated with a decrease in serum PON1 activity. Although a direct functional relationship between serum PON1 activity alterations, inflammation and fibrogenesis cannot be deduced from the present investigations, these data provide further support for studies showing that oxidative stress activates hepatic stellate cell and macrophages in vitro and in experimental models of liver impairment [32, 36-38]. A possible answer ...
Inbred mouse strains B6 and C3H have been studied extensively as a model of the genetic control of atherogenesis. In response to an atherogenic diet, B6 mice develop fatty streak lesions in the proximal aorta, whereas C3H mice are totally resistant to fatty streak formation. The present study was undertaken to determine the levels (plasma lipids, monocytes, and arterial wall cells) at which genetic variations affect atherogenesis in these 2 mouse strains.. In wild-type mouse models, atherosclerosis is induced by feeding a high-fat, high-cholesterol diet that contains cholate. In response to this diet, strain B6 mice have reduced levels of HDL compared with C3H mice.15 Moreover, this diet results in a reduction in serum paraoxonase, an HDL-associated enzyme that protects against LDL oxidation, in B6 mice but not in C3H mice.16 The apoE−/− mice represent a mouse model in which spontaneous hyperlipidemia and atherosclerosis occur with a low-fat, low-cholesterol diet.24 25 In the present study, ...
Genetic variants in the paraoxonase (PON) gene cluster, particularly a single C/T promoter polymorphism (rs 705381) in the PON-1 gene, have recently been associated with Alzheimers disease (AD). The T allele, in particular, presents an increased risk for the development of AD. Here, we investigate the potential role of this polymorphism in an Italian case-control population consisting of 306 sporadic AD patients and 275 controls, and also evaluate a possible interaction with the ApoE genotype. No association between the PON-1 polymorphism and AD was observed. The T allele frequency was slightly over-represented in AD patients compared to the controls, but this was far from being statistically significant. Our sample was evaluated to have 97.3% power to detect an OR of 2.0 (64.3% power with OR=1.5) at an alpha level of 0.05. No evidence of an interaction between the T risk-allele and the ApoE epsilon4 allele status and no effect of the PON-1 polymorphism on age at onset was detected. Our results ...
Mouse monoclonal antibody raised against full length recombinant PON1. Recombinant protein corresponding to full length human PON1. (MAB8230) - Products - Abnova
The purpose of this study is to investigate the critical role between promoter polymorphism of PON1 gene and its paraoxonase activity .....
The present study has demonstrated that glycation of apoA-I was associated with decreased activities of serum and HDL-associated PON1 and PON3. Elevated apoA-I glycation and reduced HDL-associated PON1 and PON3 activities, and the interaction of these two elements were related to the presence and severity of CAD in patients with T2DM.. HDL is an organized complex of proteins (apo and enzyme) and lipids (cholesterol, cholesteryl ester, triglyceride, and phospholipid), and possesses several functions with potential to protect against coronary atherosclerosis, by promoting efflux of cholesterol from macrophages in the arterial wall, inhibiting oxidative modification of low density lipoprotein, decreasing vascular inflammation, enhancing endothelial repair, and improving diabetic control [1, 2]. The structural and functional integrity of apoA-I is crucial for the activation and stability of lecithin:cholesterol acyl transferase (LCAT) and PON [10, 11]. Mutation, glycation and oxidative modification ...
Innovative Researchs Innovative Grade US Origin CD-1 Mouse Liver was recently used in the following study: Differences in amino acid residues in the binding pockets dictate substrate specificities of mouse senescence marker protein-30, human paraoxonase1, and squid ...T Belinskaya, N Pattabiraman, R diTargiani... - ... et Biophysica Acta (BBA ..., 2012 - Elsevier...2. Materials and methods. 2.1. Materials. Livers from CD-1 mice were purchased from Innovative Research Inc. (Novi, MI). All chromatography media and columns were purchased from GE Healthcare (Piscataway, NJ). Phenyl.... ...
Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism. This study investigates the specific role of paraoxonase, an enzyme thought to detoxify atherogenic oxidized low-density lipoprotein. This study compares veterans who have significant carotid atherosclerosis on ultrasound examination with controls without carotid atherosclerosis. Both paraoxonase activity and genotype will be determined and compared between groups. The results may eventually make it possible to screen for a paraoxonase allele that confers high risk of atherosclerosis, and to diminish the risk by early treatment. ...
We agree with the findings of Viktorinova and Kinova (1) in a recent pilot study of 75 nondiabetic white subjects (mean age 42.6 ± 7 years) with no prior history of cardiovascular disease and/or hypertension that examined the relationship between paraoxonase (PON1) enzyme activity and lipid risk factors. The authors found no significant differences in levels of HDL cholesterol and apolipoprotein (apo) A1 (apoA1) among normocholesterolemic (NC) and hypercholesterolemic (HC) men and women. However, serum PON1 activity was lower in HC groups (P , 0.05) compared with NC groups. In addition, they found positive correlations between PON1 activity and HDL cholesterol (r = 0.455, P , 0.05) and apoA1 (r = 0.697, P , 0.05) in NC women but not HC women or men. The authors postulated that low serum activity of PON1 and altered associations between PON1 activity and HDL as well as apoA1 may deteriorate beneficial functions of HDL and therefore a possible higher risk of initiation and progression of ...
The present study systematically investigated the constitutive and chemical regulation of mouse Pons. Consistent with previous reports, Pon1 and Pon3 are highly expressed in mouse liver, and Pon2 and Pon3 are expressed in the gastrointestinal tract (Mackness and Walker, 1983, 1988; Draganov et al., 2000; Ng et al., 2001). In addition, the present study indicates that Pon1, Pon2, and Pon3 all are expressed in mouse lung (Fig. 1), indicating paraxonases may play detoxification functions or other physiological roles in the lung.. In mice and rats, serum and liver Pon1 enzyme activity is very low at birth and increases until 21 days of age, with a parallel increase in liver mRNA (Li et al., 1997; Moser et al., 1998). In humans, serum PON1 activity is minimal before and at birth, but gradually increases after birth, reaching a plateau between 6 and 15 months of age (Augustinsson and Barr, 1963; Ecobichon and Stephens, 1973; Mueller et al., 1983; Cole et al., 2003). In the present study in mice, Pon1 ...
Abstract: Heart disease and stroke cause significant death and disability in industrialized nations. Oxidized low-density lipoprotein (ox-LDL) is an essential component of the plaque formation within arteries that leads to these conditions. Paraoxonase 1 (PON1) is an antioxidant enzyme capable of preventing the oxidation of LDL. The purpose of this study was to measure the relationship between ox-LDL concentration and PON1 activity in response to acute exercise. Fifteen aerobically trained individuals (M=12, F=3, VO2 max= 54.8 ± 1.7 mlkg-1min-1, BMI = 22.9± 0.5kgm-2) completed separate exercise treatment sessions at 60% and 80% VO2 max for 30 minutes. Ox-LDL concentration and PON1 activity were measured immediately before (PRE), immediately post (0 POST), and 15 minutes post (15 POST) exercise. To ascertain the degree of oxidative stress induced by the exercise sessions, protein carbonyl (PC) concentration and total antioxidant capacity (TAC) were measured at PRE and 0 POST. Repeated ...
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Recombinant Paraoxonase 1 (PON1) Protein (GST tag). Species: Human. Source: Escherichia coli (E. coli). Order product ABIN4975995.
Mouse polyclonal antibody raised against a full-length recombinant PON2. PON2 (AAH46160, 1 a.a. ~ 219 a.a) full-length recombinant protein with GST tag. (H00005445-A01) - Products - Abnova
The HIV Type 1 p24 Antigen ELISA from Zeptometrix Corporation delivered next day by Gentaur to your Lab is the best choice! The catalog number is 801200 and the price is 1.990 EUR.. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
چکیده: زمینه و هدف: پاراکسوناز-1، آدیپونکتین و پراکسید هیدروژن از جمله شاخص هایی هستند که تحت تأثیر کم تحرکی قرار می گیرند و این احتمال وجود دارد که بر فشار خون موثر باشند. با این حال ارتباط بین تغییرات آن ها با فشار خون در اثر شرکت در فعالیت های منظم ورزشی مشخص نشده است، لذا هدف از تحقیق حاضر بررسی اثر 12 هفته فعالیت هوازی شدت متوسط بر ارتباط بین تغییرات پاراکسوناز-1، پراکسید هیدروژن و آدیپونکتین پلاسمایی با فشار خون سیستولی و دیاستولی مردان دارای فشار خون بالا می باشد. روش بررسی: تحقیق حاضر از نوع نیمه تجربی با اندازه گیری مکرر می باشد که در آن 10 مرد (در ...
PON3兔单克隆抗体[EPR2903(2)](ab109258)可与小鼠, 大鼠, 人样本反应并经WB, IHC实验严格验证。中国75%以上现货,所有产品均提供质保服务,可通过电话、电邮或微信获得本地专属技术支持。
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Introduction: Previous studies have suggested that oxidative stress may play an important role in the pathogenesis of alopecia areata (AA) but these reports are limited and conflicting. ...
Background: High-density lipoprotein (HDL) cholesterol is well-established as a negative risk factor for coronary artery disease (CAD) and its anti-oxidant property has been attributed mainly to the HDL-bound enzyme paraoxonase-1 (PON-1). Recently, myeloperoxidase (MPO), a pro-oxidant enzyme released from activated neutrophils, has been shown to reverse the atheroprotective action of HDL. The aim of this study was to investigate the relationship between plasma MPO and serum PON-1 levels in patients with stable (SAP) and unstable angina pectoris (UAP).. Methods: Plasma MPO and serum PON-1 concentrations and activity were measured in patients with SAP (n=230) and UAP (n=151), and in control subjects (n=102).. Results: Plasma MPO levels were significantly higher in UAP patients than in SAP patients or control subjects (UAP, 21.6 [16.7-44.6]; SAP, 19.2 [15.6-29.1]; control, 16.0 [14.8-18.9] ng/ml; P,0.0001). Furthermore, serum PON-1 concentrations were significantly lower in UAP and SAP patients ...
Primary Objective:. Atherosclerosis of the carotid arteries is a common cause of stroke. The prevalence and progression of carotid atherosclerosis are believed to be influenced by genetically inherited variations in lipoprotein metabolism. This study investigates the specific role of paraoxonase, an enzyme thought to detoxify atherogenic oxidized low-density lipoprotein. This study compares veterans who have significant carotid atherosclerosis on ultrasound examination with controls without carotid atherosclerosis. Both paraoxonase activity and genotype will be determined and compared between groups. The results may eventually make it possible to screen for a paraoxonase allele that confers high risk of atherosclerosis, and to diminish the risk by early treatment.. Study Abstract:. The general aim of the proposed research is to evaluate the contribution and mechanism of paraoxonase (PON1) genotypic and phenotypic variation (PON1 status) in risk and progression of carotid artery disease (CAAD). ...
Paraoxonase-1 (PON1) is an antioxidant enzyme, that resides on high-density lipoprotein (HDL). PON1-activity, is heavily influenced by the PON1-Q192R polymorphism. PON1 is considered to protect against atherosclerosis, but it is unclear whether this relation is independent of its carrier, HDL. In order to evaluate the atheroprotective potential of PON1, we assessed the relationships among PON1-genotype, PON1-activity and risk of future coronary artery disease (CAD), in a large prospective case-control study. Methodology/Principal Findings: Cases (n = 1138) were apparently healthy men and women aged 45-79 years who developed fatal or nonfatal CAD during a mean follow-up of 6 years. Controls (n = 2237) were matched by age, sex and enrollment time. PON1-activity was similar in cases and controls (60.7 +/- 645.3 versus 62.6 +/- 645.8 U/L, p = 0.3) and correlated with HDL-cholesterol levels (r = 0.16, p , 0.0001). The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict ...
Human plasma paraoxonase (PON1) has been shown to have arylesterase and paraoxonase activity. This high-density lipoprotein (HDL) associated enzyme exhibits antiatherogenic properties and acts as a detoxifying agent for several chemical warfare agents and insecticides. We show that the reported purification process (Gan et al.) contains a ~68kDa co-purifying contaminant. We have developed a modified procedure using size exclusion chromatography to obtain pure PON1 from human serum. In order to support the current homology model of PON1 developed using the crystal structure of DFPase as a model, a CD spectrum of pure, monodisperse PON1 was measured. Previous attempts were inconclusive due to a high background caused by detergent micelle light scattering. The detergent free form of PON1 has been characterized to exist as monomer, dimer, and higher order soluble aggregates. Thus, detergents are necessary to retain native, monodisperse enzyme. In conjunction with our modified purification procedure, ...
Effect of lipoic acid on paraoxonase-1 and paraoxonase-3 protein levels, mRNA expression and arylesterase activity in liver hepatoma cells (Şubat 2017) ...
PON2 - PON2 (Myc-DDK-tagged)-Human paraoxonase 2 (PON2), transcript variant 2 available for purchase from OriGene - Your Gene Company.
International Journal of Hepatology is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies related to the medical, surgical, pathological, biochemical, and physiological aspects of hepatology, as well as the management of disorders affecting the liver, gallbladder, biliary tree, and pancreas.
The link between HDL and cardiovascular disease (CVD) is substantially more complex than ) originally thought. Until recently, the concentration of HDL was deemed sufficient in predicting future cardiovascular events. However, HDL function can become compromised in various disease states, resulting in reduced cardio-protection and the production of dysfunctional HDL with reduced anti-atherogenic properties. Antioxidants have been implicated in ameliorating the damaging oxidative processes associated with dysfunctional HDL and atherosclerosis. Therefore, this thesis focuses on the evolving role of HDL function and had three main aims: i) to assess the complex relationship between HDL-cholesterol concentration and HDL function, ii) to assess the modulation of HDL function by the ) predominant form of vitamin E, α-tocopherol, encompassing in vitro and ex vivo investigations and iii) to assess the modulation of HDL function by lycopene by dietary interventions. Various HDL-associated enzymes, ...
Mammals evolved in terrestrial environments. Those that now live in the marine environment have had to adapt to the particular selective pressures that this environment imposes. Meyer et al. surveyed the genomes of several marine mammal species to identify regions of convergent change. Multiple losses of the Paraoxonase 1 gene are evident in marine mammals, likely resulting from remodeling of lipid metabolism or antioxidant networks. The multiple occurrences of this loss of function across taxa indicate an evolutionary benefit. However, Paraoxonase 1 is the primary mammalian defense against organophosphorus toxicity. Marine mammals may be at a great disadvantage in the Anthropocene if run-off of this agricultural product into the marine environment continues.. Science, this issue p. 591 ...
Definition : Immunoassay reagents intended to perform quantitative analyses of body fluids (typically plasma or serum) to determine the level of the lipoprotein-associated enzyme phospholipase A2 (Lp-PLA2). These tests are usually based on turbidimetric or ELISA tests that use specific antibodies to identify the level of (Lp-PLA2). They may be used as an aid to assess vascular inflammation and the risk for coronary heart disease and ischemic stroke associated with atherosclerosis.. Entry Terms : Lipoprotein-Associated Phospholipase A2 Determination Reagents , Lp-PLA2 Determination Reagents , PLAC Test ELISA Kits , PLAC Test Reagent Kits. UMDC code : 32900 ...
Lovrić, Jasna and Berend, Suzana and Lucić Vrdoljak, Ana and Radić, Božica and Katalinić, Maja and Kovarik, Zrinka and Želježić, Davor and Kopjar, Nevenka and Rast, Slavko and Mesić, Milan (2011) A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning. Acta Biochimica Polonica, 58 (2). pp. 193-8. ISSN 0001-527X Macan, Marija and Vrkić, Nada and Lucić Vrdoljak, Ana and Radić, Božica and Bradamante, Vlasta (2010) Effects of high sucrose diet, gemfibrozil, and their combination on plasma paraoxonase 1 activity and lipid levels in rats. Acta Biochimica Polonica, 57 (3). pp. 321-6. ISSN 0001-527X ...
Cole TB, Jansen K, Park S, Li W-F, Furlong CE, Costa LG. The toxicity of mixtures of specific organophosphate compounds is modulated by paraoxonase 1 status. In: Reddy ST, ed. Paraoxonases in Inflammation, Infection, and Toxicology, Volume 660 of Advances in Experimental Medicine and Biology. New York, NY: Humana Press, 2010, Chapter 6, pp. 47-60 ...
Furlong CE, Li W-F, Cole TB, Jampsa R, Richter RJ, Jarvik GP, Shih DM, Tward A, Lusis AJ, Costa LG. Understanding the significance of genetic variability in the human PON1 gene. In: Valdes JJ, Sekowski JW, eds. Toxicogenomics and Proteomics, NATO Science Series: Life and Behavioural Sciences, Volume 356. Amsterdam, Netherlands: IOS Press, 2004 ...
Journal of Clinical and Diagnostic Research aims to publish findings of doctors at grass root level and post graduate students, so that all unique medical experiences are recorded in literature.
4-(3-Oxobutyl)phenyl acetate | C12H14O3 | CID 19137 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Association, Gene, Patients, Population, Health, Allele, Diseases, Risk, Factor Xiii, Socioeconomic Status, Disease, Human, Humans, Kidney, Kidney Disease, Lipoprotein, Paraoxonase, Paraoxonase-1, Serum, Transplant
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Kang, D.G., Kim, C.S., Seo, J.H., Kim, I.G., Choi, S.S., Ha, J.H., Nam, S.W., Lim, G., and Cha, H.J., Coexpression of molecular chaperone enhances activity and export of organophosphorus hydrolase in Escherichia coli, Biotechnology Progress (ISSN 1520-6033), Vol.28(4), pp.925-930, Willey Online Library, (2012.7 ...
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Probab=100.00 E-value=0 Score=636.12 Aligned_cols=238 Identities=42% Similarity=0.741 Sum_probs=223.6 Q ss_pred HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH Q ss_conf 99999999831231023222212468888751248999999999999999999999748999999999995302022433 Q gi,254780372,r 4 YCFFALFLVTPELVFAKSSLHDVMNIPADLSISTWIVRTFGIFTILSIAPILLIMVTCFPRFIIVFSILRTGMGMGSVPP 83 (246) Q Consensus 4 ~~~~~~~~~~~~~a~aq~~~~~~~~~~~~~~~~~~~iqll~llt~LsL~P~ilim~TsFtrIvIVLsilRnALG~QQ~PP 83 (246) T Consensus 140 ~~~~~~~~~~~p~~~~~~p~~~~~~~~~g~q~~S~~iQ~Li~lT~LsllPaiLiM~TSFtRIvIVLslLRnALG~QQ~PP 219 (379) T PRK12430 140 IIPLCFLLLFCPSAYADIPGVTSHILSDGSQTWSIPVQTLVFLTSLTFLPAFLLMMTSFTRIVIVFGLLRNALGTPYAPP 219 (379) T ss_pred HHHHHHHHHHCHHHHHCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH T ss_conf 79799999967497853885215305899801230899999999999999999998520899999999987307688986 Q ss_pred HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC Q ss_conf ...
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想知道關於什麼的眼睛常識呢?. 歡迎留言或是寫信到[email protected]》. 我們會定期撰寫相關的眼科衛教喔(. 眼睛有任何不適3請儘速就醫3本部落格文章無法取代醫師的專業診療》. ...
... s are a family of mammalian enzymes with aryldialkylphosphatase activity. There are three paraoxonase isozymes, ...
... may refer to one of two enzymes: Arylesterase Aryldialkylphosphatase This disambiguation page lists articles ...
... may refer to: Diisopropyl-fluorophosphatase, an enzyme Aryldialkylphosphatase, an enzyme This set index page ...
Aryldialkylphosphatase (also known as organophosphorus hydrolase, phosphotriesterase, and paraoxon hydrolase) uses an aryl ...
... may refer to: Aryldialkylphosphatase, an enzyme Ophiuchus, a constellation Original Pancake House, an American restaurant ...
... homocysteine thiolactonase or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. ...
... aryldialkylphosphatase MeSH D08.811.277.352.700 - ribonucleases MeSH D08.811.277.352.700.350 - endoribonucleases MeSH D08.811. ...
... aryldialkylphosphatase EC 3.1.8.2: diisopropyl-fluorophosphatase EC 3.1.11.1: exodeoxyribonuclease I EC 3.1.11.2: ...
... (EC 3.1.8.1) (more commonly known as phosphotriesterase (PTE), and also organophosphate hydrolase, ...
Aryldialkylphosphatase (EC 3.1.8.1) (more commonly known as phosphotriesterase (PTE), and also organophosphate hydrolase, ...
Paraoxonases are a family of mammalian enzymes with aryldialkylphosphatase activity. There are three paraoxonase isozymes, ...
Aryldialkylphosphatase / blood * Aryldialkylphosphatase / pharmacology * Diabetes Mellitus, Type 1 / blood* * Endothelium, ...
Aryldialkylphosphatase / metabolism* * Colitis / chemically induced* * Colitis / metabolism* * Colitis / prevention & control * ...
aryldialkylphosphatase activity Source: UniProtKB-EC. *arylesterase activity Source: UniProtKB-EC. *metal ion binding Source: ...
aryldialkylphosphatase activity Source: UniProtKB. *arylesterase activity Source: MGI ,p>Inferred from Mutant Phenotype,/p> ,p> ...
Aryldialkylphosphatase / blood. Biological Markers / metabolism. Combined Modality Therapy. Dietary Supplements*. Disease ... 0/Biological Markers; 0/Inflammation Mediators; 0/Lipids; 0/Lipoproteins; 0/Troponin I; EC 3.1.8.1/Aryldialkylphosphatase; EC ...
Serum aryldialkylphosphatase 1. *Serum paraoxonase/arylesterase 1. see all. * Function. Hydrolyzes the toxic metabolites of a ...
Rabbit polyclonal PON2 antibody. Validated in WB, IHC, Flow Cyt and tested in Human. Immunogen corresponding to synthetic peptide.
Aryldialkylphosphatase activity. Gene Name. opd. Uniprot ID. P0A434. Uniprot Name. Parathion hydrolase. Molecular Weight. ...
Aryldialkylphosphatase activity. Gene Name. opd. Uniprot ID. P0A434. Uniprot Name. Parathion hydrolase. Molecular Weight. ...
Synonyms: A-esterase 2; aromatic esterase 2; paraoxonase nirs; serum aryldialkylphosphatase 2; serum paraoxonase/arylesterase 2 ...
High-density lipoprotein (HDL) carbamylation has been known in uremia patients. Paraoxonase-1 (PON-1) is an important HDL protein… Expand ...
EC 3.1.8.1: aryldialkylphosphatase * EC 3.1.8.2: diisopropyl-fluorophosphatase EC 3.1.11: Exodeoxyribonucleases Producing 5- ...
MeSH Terms: Adiposity*/genetics; Aryldialkylphosphatase/genetics; Child; Environmental Health; Female; Humans; Infant; Maternal ...
Aryldialkylphosphatase. Coronary artery disease. Genetic. Genetic predisposition to disease. Genotype. Human. Polymorphism. ...
Serum paraoxonase/arylesterase 1 (355 aa, ~40 kDa) is encoded by the human PON1 gene. This protein plays a role in the catabolism of aromatic carboxylic acid esters, organophosphates and lactones.
Farbstein, D., Blum, S., Pollak, M., Asaf, R., Viener, H. L., Lache, O., Asleh, R., Miller-Lotan, R., Barkay, I., Star, M., Schwartz, A., Kalet-Littman, S., Ozeri, D., Vaya, J., Tavori, H., Vardi, M., Laor, A., Bucher, S. E., Anbinder, Y., Moskovich, D. & 4 othersAbbas, N., Perry, N., Levy, Y. & Levy, A. P., Nov 2011, In : Atherosclerosis. 219, 1, p. 240-244 5 p.. Research output: Contribution to journal › Article ...
Mulbry WW (1992) The aryldialkylphosphatase-encoding gene adpB from Nocardia sp. strain B-l: cloning, sequencing and expression ...
Furlong, C. E., Costa, L. G., Hassett, C., Richter, R. J., Sundstrom, J. A., Adler, D. A., Disteche, C. M., Omiecinski, C. J., Chapline, C., Crabb, J. W. & Humbert, R., Jan 1 1993, In : Chemico-Biological Interactions. 87, 1-3, p. 35-48 14 p.. Research output: Contribution to journal › Article ...
Aryldialkylphosphatase (also known as organophosphorus hydrolase, phosphotriesterase, and paraoxon hydrolase) uses an aryl ...
Serum paraoxonase/arylesterase 1, PON 1 (Aromatic esterase 1) (A-esterase 1) (Serum aryldialkylphosphatase 1) ...
Serum aryldialkylphosphatase 2. Gene name: PON2 Serum paraoxonase/arylesterase 2 (PON2) antibody ...
A-esterase 2,aromatic esterase 2,paraoxonase nirs,serum aryldialkylphosphatase 2,serum paraoxonase/arylesterase 2 ...
animal models; aryldialkylphosphatase; foods; gene expression; high density lipoprotein; humans; in vivo studies; lipid ...
Fingerprint Dive into the research topics where Egon Anderson Ozer is active. These topic labels come from the works of this person. Together they form a unique fingerprint. ...
TY - JOUR. T1 - A common mutation in paraoxonase-2 results in impaired lactonase activity. AU - Stoltz, David A.. AU - Ozer, Egon A.. AU - Recker, Thomas J.. AU - Estin, Miriam. AU - Yang, Xia. AU - Shih, Diana M.. AU - Lusis, Aldons J.. AU - Zabner, Joseph. PY - 2009/12/18. Y1 - 2009/12/18. N2 - Paraoxonases (PONs) are a family of lactonases with promiscuous enzyme activity that has been implicated in multiple diseases. PON2 is intracellularly located, is the most ubiquitously expressed PON, and has the highest lactonase activity of the PON family members. Whereas some single-nucleotide polymorphisms (SNPs) in PON1 have resulted in altered enzymatic activity in serum, to date the functional consequences of SNPs on PON2 function remain unknown. We hypothesized that a common PON2 SNP would result in impaired lactonase activity. Substitution of cysteine for serine at codon 311 in recombinant PON2 resulted in normal protein production and localization but altered glycosylation and decreased ...
  • Aryldialkylphosphatase (EC 3.1.8.1) (more commonly known as phosphotriesterase (PTE), and also organophosphate hydrolase, parathion hydrolase, paraoxonase, and parathion aryl esterase) is a metalloenzyme that hydrolyzes the triester linkage found in organophosphate insecticides. (wikipedia.org)
  • Paraoxonase (PON) is an aryldialkylphosphatase, which reversibly binds and hydrolyzes organophosphates. (scienceopen.com)
  • Paraoxonases are a family of mammalian enzymes with aryldialkylphosphatase activity. (wikipedia.org)