Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. The complex binds xenobiotic regulatory elements and activates transcription of a variety of genes including UDP GLUCURONOSYLTRANSFERASE. AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1.
Cytoplasmic proteins that bind certain aryl hydrocarbons, translocate to the nucleus, and activate transcription of particular DNA segments. AH receptors are identified by their high-affinity binding to several carcinogenic or teratogenic environmental chemicals including polycyclic aromatic hydrocarbons found in cigarette smoke and smog, heterocyclic amines found in cooked foods, and halogenated hydrocarbons including dioxins and polychlorinated biphenyls. No endogenous ligand has been identified, but an unknown natural messenger with a role in cell differentiation and development is suspected.
A chemical by-product that results from burning or incinerating chlorinated industrial chemicals and other hydrocarbons. This compound is considered an environmental toxin, and may pose reproductive, as well as, other health risks for animals and humans.
A liver microsomal cytochrome P-450 monooxygenase capable of biotransforming xenobiotics such as polycyclic hydrocarbons and halogenated aromatic hydrocarbons into carcinogenic or mutagenic compounds. They have been found in mammals and fish. This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity.
Chlorinated hydrocarbons containing heteroatoms that are present as contaminants of herbicides. Dioxins are carcinogenic, teratogenic, and mutagenic. They have been banned from use by the FDA.
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
A condition of decreased oxygen content at the cellular level.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
A large group of cytochrome P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze hydroxylation of a broad spectrum of substrates and are important in the metabolism of steroids, drugs, and toxins such as PHENOBARBITAL, carcinogens, and insecticides.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A major group of unsaturated cyclic hydrocarbons containing two or more rings. The vast number of compounds of this important group, derived chiefly from petroleum and coal tar, are rather highly reactive and chemically versatile. The name is due to the strong and not unpleasant odor characteristic of most substances of this nature. (From Hawley's Condensed Chemical Dictionary, 12th ed, p96)
Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.
A potent mutagen and carcinogen. It is a public health concern because of its possible effects on industrial workers, as an environmental pollutant, an as a component of tobacco smoke.
An agent that causes the production of physical defects in the developing embryo.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Chemical substances that are foreign to the biological system. They include naturally occurring compounds, drugs, environmental agents, carcinogens, insecticides, etc.
A polyaromatic hydrocarbon inducer of P4501A1 and P4501A2 cytochromes. (Proc Soc Exp Biol Med 1994 Dec:207(3):302-308)
Organic compounds containing a BENZENE ring attached to a flavone group. Some of these are potent arylhydrocarbon hydroxylase inhibitors. They may also inhibit the binding of NUCLEIC ACIDS to BENZOPYRENES and related compounds. The designation includes all isomers; the 7,8-isomer is most frequently encountered.
A carcinogen that is often used in experimental cancer studies.
An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.
Industrial products consisting of a mixture of chlorinated biphenyl congeners and isomers. These compounds are highly lipophilic and tend to accumulate in fat stores of animals. Many of these compounds are considered toxic and potential environmental pollutants.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Specialized arterial vessels in the umbilical cord. They carry waste and deoxygenated blood from the FETUS to the mother via the PLACENTA. In humans, there are usually two umbilical arteries but sometimes one.
The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.
An anti-inflammatory 9-fluoro-glucocorticoid.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
Cytoplasmic proteins that specifically bind glucocorticoids and mediate their cellular effects. The glucocorticoid receptor-glucocorticoid complex acts in the nucleus to induce transcription of DNA. Glucocorticoids were named for their actions on blood glucose concentration, but they have equally important effects on protein and fat metabolism. Cortisol is the most important example.
Proteins found usually in the cytoplasm or nucleus that specifically bind steroid hormones and trigger changes influencing the behavior of cells. The steroid receptor-steroid hormone complex regulates the transcription of specific genes.
Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
The portion of an interactive computer program that issues messages to and receives commands from a user.
Sequential operating programs and data which instruct the functioning of a digital computer.
Relatively complete absence of oxygen in one or more tissues.
A cell line derived from cultured tumor cells.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

AhR, ARNT, and CYP1A1 mRNA quantitation in cultured human embryonic palates exposed to TCDD and comparison with mouse palate in vivo and in culture. (1/421)

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is developmentally toxic in many species and induces cleft palate in the C57BL/6N mouse embryo. Palatogenesis in mouse and human embryos involves homologous processes at the morphological, cellular, and molecular levels. In organ culture, mouse and human palates respond similarly to TCDD. The present study quantitates the expression of AhR, ARNT, and CYP1A1 mRNA in human embryonic palates in organ culture. Palatal tissues were exposed to 1 x 10(-10), 1 x 10(-9), or 1 x 10(-8) M TCDD or control medium and sampled at 0, 2, 4, and 6 hours for quantitative RT-PCR using a synthetic RNA internal standard. Similar measurements of CYP1A1 gene expression were collected for mouse palates cultured in this model. In human palates, AhR expression correlated with ARNT and CYP1A1 mRNA expression. TCDD induction of CYP1A1 was time- and concentration-dependent. The expression of these genes presented a uniform and continuous distribution across the group of embryos, with no subset of either high or low expressors/responders. The ratio of AhR to ARNT was approximately 4:1. AhR mRNA increased during the culture period in both treated and control subjects; however, ARNT expression was relatively constant. TCDD did not alter either AhR or ARNT expression in a consistent dose- or time-related manner. Comparison of human and mouse data showed a high correlation across species for the induction of CYP1A1. Human embryos expressed approximately 350 times less AhR mRNA than the mouse, and in earlier studies it was shown that human palates required 200 times more TCDD to produce the same effects. When the morphological, cellular, and molecular responses to TCDD between mouse and human are compared, it seems highly unlikely that human embryos could be exposed to sufficient TCDD to achieve changes in palatal differentiation that would lead to cleft palate.  (+info)

RT-PCR quantification of AHR, ARNT, GR, and CYP1A1 mRNA in craniofacial tissues of embryonic mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and hydrocortisone. (2/421)

C57BL/6N mouse embryos exposed to hydrocortisone (HC) or 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) develop cleft palate. An interaction between these agents produces clefts at doses which alone are not teratogenic. The glucocorticoid receptor (GR) and dioxin receptor (AhR) mediated these responses and their gene expression was altered by TCDD and/or HC in palates examined on gestation day (GD) 14 by Northern blot analysis and in situ hybridization. The present study quantifies AhR, AhR nuclear translocator (ARNT), and GR mRNA at 4, 12, 24, and 48 h after exposure (time 0 = dose administration at 8 A.M. on gestation day 12) on GD12 to TCDD (24 micrograms/kg), HC (100 mg/kg) or HC (25 mg/kg) + TCDD (3 micrograms/kg). The induction of CYP1A1 mRNA was also quantified at 2, 4, 6, 12, 24, and 48 h for control and TCDD-exposed samples. Total RNA was prepared from midfacial tissue of 4-6 embryos/litter at each time and dose. An RNA internal standard (IS) for each gene was synthesized, which included the gene's primer sequences separated by a pUC19 plasmid sequence. Reverse transcription-polymerase chain reaction (RT-PCR) was performed on total RNA + IS using a range of 5-7 IS concentrations across a constant level of total RNA. PCR products were separated in gels (mRNA and IS-amplified sequences differed by 30-50 bases), ethidium bromide-stained, imaged (Hamamatsu Photonics Systems, Bridgewater, NJ), and quantified with NIH Image. CYP1A1 mRNA was significantly induced in the TCDD-exposed samples at all time points examined (p = 0.005 at 2 h and 0.001 after 2 h). During palatal shelf outgrowth on GD12, AhR mRNA levels increased significantly and this was not affected by treatment with TCDD or HC + TCDD. A significant increase in GR was detected at 24 h (p < 0.05) and this was unaffected by any of the exposures. Expression of ARNT increased at 12 h (p < 0.001); however, treatment with HC or HC + TCDD blocked this increase (p < 0.05). At 24 h, the TCDD-treated embryos had significantly lower ARNT mRNA compared with controls (p < 0.001). The relative overall expression level of the genes was AhR > ARNT > GR. Within individuals, expression of AhR and/or ARNT was highly correlated with GR level. In conclusion, CYP1A1 mRNA was expressed in developing craniofacial tissue and was highly induced by TCDD exposure. AhR, ARNT, and GR mRNA are upregulated in early palatogenesis, although not on the same schedule. The TCDD-induced decrease in ARNT at 24 h after dosing and the HC and HC + TCDD-induced delay in upregulation of ARNT may affect the dynamics of heterodimer formation between AhR and ARNT. The changes in ARNT mRNA level could also affect availability of this transcriptional regulator to interact with other potential partners, and these effects, separately or in combination, may be involved in disruption of normal embryonic development.  (+info)

Inhibition of hypoxia-inducible factor 1 activation by carbon monoxide and nitric oxide. Implications for oxygen sensing and signaling. (3/421)

It has been proposed that cells sense hypoxia by a heme protein, which transmits a signal that activates the heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1), thereby inducing a number of physiologically relevant genes such as erythropoietin (Epo). We have investigated the mechanism by which two heme-binding ligands, carbon monoxide and nitric oxide, affect oxygen sensing and signaling. Two concentrations of CO (10 and 80%) suppressed the activation of HIF-1 and induction of Epo mRNA by hypoxia in a dose-dependent manner. In contrast, CO had no effect on the induction of HIF-1 activity and Epo expression by either cobalt chloride or the iron chelator desferrioxamine. The affinity of CO for the putative sensor was much lower than that of oxygen (Haldane coefficient, approximately 0.5). Parallel experiments were done with 100 microM sodium nitroprusside, a nitric oxide donor. Both NO and CO inhibited HIF-1 DNA binding by abrogating hypoxia-induced accumulation of HIF-1alpha protein. Moreover, both NO and CO specifically targeted the internal oxygen-dependent degradation domain of HIF-1alpha, and also repressed the C-terminal transactivation domain of HIF-1alpha. Thus, NO and CO act proximally, presumably as heme ligands binding to the oxygen sensor, whereas desferrioxamine and perhaps cobalt appear to act at a site downstream.  (+info)

Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. (4/421)

Hypoxia-inducible factor-1 (HIF-1) is a master regulator of mammalian oxygen homeostasis. HIF-1 consists of two subunits, HIF-1alpha and the aryl hydrocarbon receptor nuclear translocator (ARNT). Whereas hypoxia prevents proteasomal degradation of HIF-1alpha, ARNT expression is thought to be oxygen-independent. We and others previously showed that ARNT is indispensable for HIF-1 DNA-binding and transactivation function. Here, we have used ARNT-mutant mouse hepatoma and embryonic stem cells to examine the requirement of ARNT for accumulation and nuclear translocation of HIF-1alpha in hypoxia. As shown by immunofluorescence, HIF-1alpha accumulation in the nucleus of hypoxic cells was independent of the presence of ARNT, suggesting that nuclear translocation is intrinsic to HIF-1alpha. Co-immunoprecipitation of HIF-1alpha together with ARNT could be performed in nuclear extracts but not in cytosolic fractions, implying that formation of the HIF-1 complex occurs in the nucleus. A proteasome inhibitor and a thiol-reducing agent could mimic hypoxia by inducing HIF-1alpha in the nucleus, indicating that escape from proteolytic degradation is sufficient for accumulation and nuclear translocation of HIF-1alpha. During biochemical separation, both HIF-1alpha and ARNT tend to leak from the nuclei in the absence of either subunit, suggesting that heterodimerization is required for stable association within the nuclear compartment. Nuclear stabilization of the heterodimer might also explain the hypoxically increased total cellular ARNT levels observed in some of the cell lines examined.  (+info)

Protein kinase C modulates aryl hydrocarbon receptor nuclear translocator protein-mediated transactivation potential in a dimer context. (5/421)

Protein kinase C (PKC)- and protein kinase A (PKA)-mediated modulation of the transactivation potential of human aryl hydrocarbon receptor nuclear translocator (hARNT), a basic helix-loop-helix (bHLH)-PAS transcription factor, and the bHLH-ZIP transcription factors USF-1 (for upstream regulatory factor 1) and c-Myc were examined. An 81 nM dose of the PKC activator phorbol-12-myristate-13-acetate (PMA), shown here to specifically activate PKC in COS-1 cells, or a 1 nM dose of the PKA activator 8-bromoadenosine-3',5'-cyclic monophosphate (8-Br-cAMP) results in 2. 6- and 1.9-fold enhancements, respectively, in hARNT-mediated transactivation of the class B, E-box-driven reporter pMyc3E1bLuc relative to identically transfected, carrier solvent-treated COS-1 cells. In contrast, 81 nM PMA and 1 nM 8-Br-cAMP did not enhance transactivation of pMyc3E1bLuc-driven by USF-1 and c-Myc expression relative to identically transfected, carrier-treated COS-1 cells. Co-transfection of pcDNA3/ARNT-474-Flag, expressing a hARNT carboxyl-terminal transactivation domain deletion, and pMyc3E1bLuc does not result in induction of reporter activity, suggesting PMA's effects do not involve formation of unknown hARNT-protein heterodimers. Additionally, PMA had no effect on hARNT expression relative to Me2SO-treated cells. Metabolic 32P labeling of hARNT in cells treated with carrier solvent or 81 nM PMA demonstrates that PMA does not increase the overall phosphorylation level of hARNT. These results demonstrate, for the first time, that the transactivation potential of ARNT in a dimer context can be specifically modulated by PKC or PKA stimulation and that the bHLH-PAS and bHLH-ZIP transcription factors are differentially regulated by these pathways in COS-1 cells.  (+info)

Repression of dioxin signal transduction in fibroblasts. Identification Of a putative repressor associated with Arnt. (6/421)

Heterodimeric complexes of basic helix-loop-helix/PAS transcription factors are involved in regulation of diverse physiological phenomena such as circadian rhythms, reaction to low oxygen tension, and detoxification. In fibroblasts, the basic helix-loop-helix/PAS heterodimer consisting of the ligand-inducible dioxin receptor and Arnt shows DNA-binding activity, and the receptor and Arnt are able to activate transcription when fused to a heterologous DNA-binding domain. However, fibroblasts are nonresponsive to dioxin with regard to induction mediated by the DNA response element recognized by the receptor and Arnt. Here we demonstrate that Arnt is associated with a fibroblast-specific factor, forming a complex that is capable of binding the dioxin response element. This factor may function as a repressor since negative regulation of target gene induction appears to be abolished by inhibition of histone deacetylase activity by trichostatin A. Finally, the negative regulatory function of this factor appears to be restricted for dioxin signaling since Arnt was able to mediate, together with hypoxia-inducible factor-1alpha, transcriptional activation in hypoxic cells. Taken together, these data suggest that fibroblast-specific inhibition of dioxin responsiveness involves recruitment by Arnt of a cell type- and signaling pathway-specific corepressor associated with a histone deacetylase.  (+info)

Aromatic hydrocarbon nuclear translocator as a common component for the hypoxia- and dioxin-induced gene expression. (7/421)

Aromatic hydrocarbon nuclear translocator (Arnt) is an ubiquitously expressed protein that contains basic helix-loop-helix (bHLH) and Per-AhR-Arnt-Sim (PAS) motifs. Other bHLH-PAS proteins, hypoxia-inducible factor-1alpha (HIF-1alpha) and aromatic hydrocarbon receptor (AhR) mediate hypoxia- and dioxin-signal pathway, respectively. Arnt has been identified as a heterodimerization partner for AhR. AhR/Arnt heterodimer binds the regulatory region of xenobiotic-induced genes and activates their transcription. Here, in vivo results provide evidence that Arnt is involved in not only xenobiotic- but also hypoxia-induced transcriptional activation. In hypoxic condition, Arnt dimerizes with HIF-1alpha to make HIF-1alpha/Arnt heterodimer which is able to bind hypoxia-responsive DNA elements. The HIF-1alpha/Arnt heterodimer functions as a transactivator for hypoxia-inducible genes. Given that the expression of Arnt is limited, HIF-1alpha may compete with AhR for recruiting Arnt as a heteromeric partner. Consistent with this idea, the results indicate that the hypoxic activation of HIF-1alpha reduces dioxin-induced AhR's function on the dioxin-responsive reporter gene and the endogenous gene.  (+info)

Expression of CYP1A1 and CYP1B1 depends on cell-specific factors in human breast cancer cell lines: role of estrogen receptor status. (8/421)

The impact of estrogen receptor (ER) was examined for expression and activity of cytochrome P4501B1 (CYP1B1) and cytochrome P4501A1 (CYP1A1) in two pairs of ER+/ER- human breast epithelial cell lines derived from single lineages, and representing earlier (T47D) or later (MDA-MB-231) stages of tumorigenesis. Acute loss of ER was evaluated using the anti-estrogen ICI 182,780 (ICI). In all lines, CYP1B1 was expressed constitutively and was induced by 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD), whereas CYP1A1 was expressed only following induction. Expression of each CYP (with or without TCDD) was greater in T47D cells than MDA cells. The ER impacted expression of these genes in opposite directions. The ER- phenotype was associated with less TCDD-induced CYP1A1 expression, but greater basal and induced CYP1B1 expression. A 48 h treatment of ER+ cells with ICI did not revert the P450 expression pattern to that of ER- cells. Based on activities of recombinant enzyme and expression levels, differences in 7,2-dimethylbenz [a]anthracene (DMBA) metabolism between the cell lines were consistent with differences in CYP1A1 and CYP1B1 expression. In T47D lines, basal microsomal DMBA metabolism was primarily due to CYP1B1, based on regioselective metabolite distribution and inhibition by anti-CYP1B1 antibodies (>80%). Metabolism in TCDD-induced microsomes was mostly due to CYP1A1 and was inhibited by anti-CYP1A1 antibody (>50%). TCDD-induced MDA+ cells demonstrated CYP1A1 activity, whereas TCDD-induced MDA- cells displayed CYP1B1 activity. Aryl hydrocarbon receptor (AhR) levels, but not AhR nuclear translocator protein (ARNT) levels were highly dependent on cell type; AhR was high and ER-independent in MDA, and low and ER-linked in T47D. AhR levels were insensitive to ICI. ER does not directly modulate the expression of CYP1A1, CYP1B1 or AhR. Indeed, factors that have replaced ER in growth regulation during clonal selection predominate in this regulation. Characteristics unique to each cell line, including ER status, determine CYP1A1 and CYP1B1 expression.  (+info)

BACKGROUND: Replacing beta-cells by islet-transplantation can cure type 1 diabetes, but up to 70% of beta-cells die within 10 days of transplantation. ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) regulates beta-cell function, and potentially survival. Lack of ARNT impairs the ability of beta-cells to respond to physiological stress and potentiates the onset of diabetes, but the exact role of ARNT in graft outcome is unknown. AIM: To investigate the effect of beta-cell deletion of ARNT on graft outcomes. METHODS: Islets were isolated from donor mice which had beta-cell specific ARNT-deletion (beta-ARNT) or littermate floxed controls. The islets were transplanted into diabetic SCID recipients in ratios of (a) 3 donors: 1 recipient, (b) 1 donor: 1 recipient or (c) (1/2) of the islets from 1 donor: 1 recipient. After 28 days, the kidney containing the graft was removed (nephrectomy) to exclude regeneration of the endogenous pancreas. RESULTS: In the supra-physiological-mass model (3:1), both groups
Pregnancies complicated by severe fetal growth restriction with abnormal umbilical artery Doppler velocimetry (FGRadv) are at substantial risk for adverse perinatal and long-term outcomes. Impaired angiogenesis of the placental vasculature in these pregnancies results in a sparse, poorly branched vascular tree, which structurally contributes to the abnormally elevated fetoplacental vascular resistance that is clinically manifested by absent or reversed umbilical artery Doppler indices. Previous studies have shown that aryl hydrocarbon receptor nuclear translocator (ARNT) is a key mediator of proper placental angiogenesis, and within placental endothelial cells (ECs) from human FGRadv pregnancies, low expression of ARNT leads to decreased vascular endothelial growth factor A (VEGFA) expression and deficient tube formation. Thus, the aim of the present study was to determine the effect of VEGFA administration or ARNT overexpression on angiogenic potential of FGRadv ECs. ECs were isolated and ...
TY - JOUR. T1 - Role of AhR/ARNT system in skin homeostasis. AU - Furue, Masutaka. AU - Takahara, Masakazu. AU - Nakahara, Takeshi. AU - Uchi, Hiroshi. PY - 2014/1/1. Y1 - 2014/1/1. N2 - Aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor that binds to structurally diverse synthetic and naturally occurring chemicals including dioxins, flavonoids, tryptophan photoproducts, and Malassezia metabolites. Upon binding to its ligands, cytoplasmic AhR translocates to the nucleus, heterodimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT), and mediates numerous biological and toxicological effects by inducing the transcription of various AhR-responsive genes. AhR ligation controls oxidation/antioxidation, epidermal barrier function, photo-induced response, melanogenesis, and innate immunity. This review summarizes recent advances in the understanding of the regulatory mechanisms of skin homeostasis mediated by the AhR/ARNT system.. AB - Aryl hydrocarbon receptor ...
The Drosophila spineless (ss) gene encodes a basic-helix-loop-helix-PAS transcription factor that is required for proper specification of distal antennal identity, establishment of the tarsal regions of the legs, and normal bristle growth. ss is the closest known homolog of the mammalian aryl hydrocarbon receptor (Ahr), also known as the dioxin receptor. Dioxin and other aryl hydrocarbons bind to the PAS domain of Ahr, causing Ahr to translocate to the nucleus, where it dimerizes with another bHLH-PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt). Ahr:Arnt heterodimers then activate transcription of target genes that encode enzymes involved in metabolizing aryl hydrocarbons. In this report, we present evidence that Ss functions as a heterodimer with the Drosophila ortholog of Arnt, Tango (Tgo). We show that the ss and tgo genes have a close functional relationship: loss-of-function alleles of tgo were recovered as dominant enhancers of a ss mutation, and tgo-mutant somatic ...
Simple helixCloopChelix/PerCArntCSim (bHLH/PAS) transcription factors function broadly in development, stress and homeostasis response. particular features of neuronal bHLH/PAS elements and/or to prevent neuronal bHLH/PAS Rabbit Polyclonal to EFNB3 elements from interfering with AhR/Arnt signalling. Launch The mammalian simple helixCloopChelix/PerCArntCSim (bHLH/PAS) family members of transcription elements comprises of 19 structurally related protein that are important for a variety of natural procedures, including air homeostasis, xenobiotic Lumacaftor response, neurogenesis, urge for food control and circadian tempo (1,2). Prototypical signal-regulated associates of this family members consist of the aryl hydrocarbon receptor (AhR) and hypoxia-inducible factor-alphas (HIF-s), which exert their actions by heterodimerizing with the common bHLH/PAS partner proteins aryl hydrocarbon receptor nuclear translocator (Arnt), to type energetic DNA-binding processes. In addition, Arnt provides been ...
Project Description: Damage to nerve fibers along with degeneration and death of neurons (neurodegeneration) are associated with chronic disability in MS. Dr. Jacqueline Quandt and her research team aim to characterize the role of neuronal PAS4 (Npas4) and aryl hydrocarbon receptor nuclear translocator (ARNT2), two molecules with an established role in damage of nerve fibers and neurodegeneration. These molecules have neuroprotective properties, the potential to influence the earliest steps of neurodegeneration at disease onset, as well as the potential to contribute to recovery while limiting progression in MS. From a previous grant, also supported by the MS Society, the research team shows that both Npas4 and ARNT2 are regulated over the disease course of an animal model of MS: prior to disease onset each are increased, presumably in response to early stressors, yet levels decline with disease onset and are lowest at peak disease. The research team will (1) localize and compare Npas4 and ARNT2 ...
Hypoxia, a condition of low tissue O2 concentration, plays an important role in normal physiological processes and tumor formation. Under hypoxic conditions mammalian cells up regulate the expression of hypoxic genes, including induction of angiogenesis and a switch to anaerobic metabolism, in order to survive. HIF-1 (Hypoxia Inducible Factor-1) is one of the key regulators of the transcriptional response to oxygen deprivation (1). HIF-1 is composed of two subunits, HIF-1alphaand HIF-1beta also known as aryl hydrocarbon receptor nuclear translocator (ARNT)) that are members of the basic helix-loop-helix (bHLH) Per-Arnt-Sim (PAS) (bHLH-PAS) family of transcription factors. HIF-1 is essential for angiogenesis, embryonic development, and is associated with tumor progression, erythropoiesis, vascular development/remodeling, vasodilation, and glucose/energy metabolism. The over expression of HIF-1alphahas been demonstrated in many common human cancers including prostate and breast, in which ...
Low oxygen levels (hypoxia) trigger a variety of adaptive responses with the Hypoxia-inducible factor 1 (HIF-1) complex acting as a master regulator. HIF-1 consists of a heterodimeric oxygen-regulated ? subunit (HIF-1?) and constitutively expressed ? subunit (HIF-1?) also known as aryl hydrocarbon receptor nuclear translocator (ARNT), regulating genes involved in diverse processes including angiogenesis, erythropoiesis and glycolysis. The identification of HIF-1 interacting proteins is key to the understanding of the hypoxia signaling pathway. Besides the regulation of HIF-1? stability, hypoxia also triggers the nuclear translocation of many transcription factors including HIF-1? and ARNT. Notably, most of the current methods used to study such protein-protein interactions (PPIs) are based on systems where protein levels are artificially increased through protein overexpression. Protein overexpression often leads to non-physiological results arising from temporal and spatial artifacts. Here we ...
Objectives Dioxin-like chemicals are known to exert their effect by binding to aryl hydrocarbon receptor (AhR), forming complexes with aryl hydrocarbon nuclear translocator (ARNT), and binding to specific dioxin responsive elements in promoter region to regulate the transcription of specific genes. In human, induction of cytochrome P450 (CYP) family of enzymes is well documented. In previous study, CYP1A2 induction had been reported to be an excellent biomarker of dioxin exposure and human health effects in people highly exposed to dioxin-like chemicals, the Yucheng cohort. The goal of this study is to examine the relationship between inducibility of CYP1A2 and genetic polymorphisms of AhR, ARNT, and AhRR in human.. ...
11-26-20 Otc omeprazole d cost, omeprazole order now store. Throughout the long years of operation our company has become synonymous to quality. Top Offers For Omeprazole - BUY HERE. Truly clever customers choose our pharmacy because it is the best of all similar services. Activation of the AhR doesnt solely act on CYP1A1 but on a variety of molecules. The aryl hydrocarbon nuclear translocator is a crucial issue within the pathway of the hypoxia-inducible components (HIF-1О± and HIF-2О±) as ARNT serves as a dimerization associate. Prilosec and Zantac both scale back acid ranges in the stomach to relieve symptoms of acid reflux disorder. I purchased $200 price of this product and appear to be caught with it as there isnt any option to return, likely as a result of it is a medication. For reference I have returned one Amazon merchandise in over 15 years, a book which was lacking a bunch of pages. After 4 days of taking this product I had dangerous heartburn. How To Store Omeprazole Order now ...
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R. L. Tanguay, Andreasen, E., Heideman, W., and Peterson, R. E., Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1494, no. 1-2, pp. 117 - 128, 2000. ...
R. L. Tanguay, Andreasen, E., Heideman, W., and Peterson, R. E., Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions., Biochim Biophys Acta, vol. 1494, no. 1-2, pp. 117-28, 2000. ...
R. L. Tanguay, Andreasen, E., Heideman, W., and Peterson, R. E., Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions., Biochim Biophys Acta, vol. 1494, no. 1-2, pp. 117-28, 2000. ...
R. L. Tanguay, Andreasen, E., Heideman, W., and Peterson, R. E., Identification and expression of alternatively spliced aryl hydrocarbon nuclear translocator 2 (ARNT2) cDNAs from zebrafish with distinct functions, Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression, vol. 1494, no. 1-2, pp. 117 - 128, 2000. ...
Here, we report a renoprotective mechanism that is controlled by the transcription factor ARNT, which effectively inhibits progression of chronic kidney injury by inducing ALK3 transcription. We further report that ARNT expression itself is controlled by the FKBP12/YY1 transcriptional repressor complex (Supplemental Figure 12A) and that disruption of such FKBP12/YY1 complexes by picomolar FK506 at subimmunosuppressive doses, small molecule FKBP12 inhibitor GPI-1046, or direct targeting of FKBP12/YY1 using VMOs increases ARNT levels (Supplemental Figure 12B). Subsequent activation of ALK3-dependent canonical BMP-signaling responses by ARNT homodimer formation (independently of HIF1α or AHR) attenuates chronic organ failure in models of chronic kidney, cardiac, and liver injuries (Supplemental Figure 12, C and D). The identified FKBP12/YY1/ARNT/ALK3 signaling axis is supported by mining of public expression profiling databases in various organs: in the context of the kidney, an inverse ...
Fingerprint Dive into the research topics of Deciphering Dimerization Modes of PAS Domains: Computational and Experimental Analyses of the AhR:ARNT Complex Reveal New Insights Into the Mechanisms of AhR Transformation. Together they form a unique fingerprint. ...
The PAS region [1,2] is an approximately 300 amino-acid conserved region who was first isolated in the Drosophila protein period clock (PER), the Ah receptor nuclear translocator (ARNT) and the Drosophila single-minded (SIM). It is composed of two or more imperfect repeats. Within the bHLH/PAS proteins the PAS region is involved in protein dimerization with another protein of the same family. It has also been associated with light reception, light regulation and circadian rhythm regulators (clock). In bacteria, the PAS repeat is usually associated with the input domain of a histidine kinase, or a sensor protein that regulates a histidine kinase. The PAS repeat is often associated with a PAC motif (PAS-associated C-terminal motif), a conserved region of 40-45 amino acids situated carboxy-terminal to any PAS repeat and which can contribute to the PAS structural domain. The PAS family can be divided into two groups. The first group contains the PAS domain followed by a PAC motif: ...
This project sought to identify which amino acid residues of cyclo-CLLFVY were critical to its activity by synthesising five alanine analogues and testing them in cell and biophysical assays. It was not possible to identify an active motif and it could be concluded that the specific conformation of the intact cyclic peptide is required for activity. The functionality of independently bacterially expressed fragments of HIF-1? and HIF-1? was also validated by an EMSA. The Tavassoli group used these proteins to establish the binding location of the inhibitor to the HIF-1?-PAS-B domain (work by A. Tavassoli and A. Male ...
The vT{2} cell line was derived by co-transfection of a 6 thioguanine-resistant derivative of c4 (B13NBii1) [ATCC CRL-2717] cell line using the plasmid pSV2gpt and pBM5/NEO-M1-1. M1-1 is a cDNA clone containing the entire human ARNT cDNA sequence. The cells were expanded in G418 to obtain vT{2} (ATCC CRL-2712). The vT{2} cell line expresses the human aryl hydrocarbon receptor nuclear translocator (ARNT) gene The vectors contain cytomegalovirus (CMV) and SV40 viral DNA sequences and the neomycin resistance gene. ARNT is directly involved in the regulation of xenobiotic metabolism (including chemical carcinogenesis), hypoxia and differentiation during embryogeneses. The parental cell line c4 (B13NBii1) (ATCC CRL-2717) lacks functional ARNT while its derivative vT{2} (ATCC CRL-2712) possesses a complete transfected ARNT cDNA. Together, they can be used to study ARNT processes and the role of ARNT in vivo.
Mouse anti Human ARNT antibody, clone 3D10 recognizes human Aryl hydrocarbon receptor nuclear translocator, also known as ARNT, Class E ba
Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells.Conformational changes in inhibitory PAS domain protein associated with binding of HIF-1α and Bcl-xL in living cells. ...
There are limited information and not many adequately powered random- ized trials with regard to the post of adjuvant chemotherapy after extremist surgery for the treatment of cervical cancer. The AhR also contains other structural motifs that are paramount against its deed, including the PAS-A and PAS-B domains that participate in protein dimerisation and ligand binding. So who would help from a clean buy fildena 150mg without a prescription erectile dysfunction miracle shake. Since the biological sketch out of lung conglomeration facilitates expeditious oxygenation of blood as it perfuses the alveolar spaces, lungs do not obtain ana- tomical barriers restricting the accumulation of foreign airborne chemicals. Whether working with an interpreter in myself or in the phone, it is substantial to coordinate efforts so that both the m‚nage and the interpreter catch on to the information to be communicated. Kumar VA, Yeun JY, Depner TA, et al buy penegra 100 mg amex prostate kegels. We deliver ...
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TY - JOUR. T1 - Ligand-independent activation of the arylhydrocarbon receptor by ETK (Bmx) tyrosine kinase helps MCF10AT1 breast cancer cells to survive in an apoptosis-inducing environment. AU - Fujisawa, Yasuko. AU - Li, Wen. AU - Wu, Dalei. AU - Wong, Patrick. AU - Vogel, Christoph. AU - Dong, Bin. AU - Kung, Hsing Jien. AU - Matsumura, Fumio. PY - 2011/10/1. Y1 - 2011/10/1. N2 - It has been reported that the arylhydrocarbon receptor (AHR) is overexpressed in certain types of breast tumors. However, so far no concrete evidence has been provided yet as to why and how the overexpressed AHR in those cancer cells is functionally activated without exogenous ligands. Here we show that the AHR was functionally activated when estrogen receptor-negative, AHR overexpressing MCF10AT1 human breast cancer cells (designated P20E) were subjected to serum starvation. Transfection of cells with ETK-KQ, a plasmid for kinase-dead epithelial and endothelial tyrosine kinase (ETK), attenuated this AHR activation. ...
TY - JOUR. T1 - Mechanism of action and development of selective aryl hydrocarbon receptor modulators for treatment of hormone-dependent cancers (Review).. AU - Safe, Stephen. AU - McDougal, Andrew. PY - 2002/6. Y1 - 2002/6. N2 - Ligand-activated receptors are extensively used as targets for developing tissue-selective drugs for treatment of multiple diseases including cancers. The aryl hydrocarbon receptor (AhR) is a basic helix-loop-helix transcription factor that binds both synthetic chemicals such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and naturally-occurring phytochemicals, sterols and heme breakdown products. The high affinity ligand TCDD induces several AhR-mediated changes in gene expression, tissue/species-specific toxicities, and both tumorigenic and anticarcinogenic responses including inhibition of estrogen-dependent mammary and uterine tumor formation and growth. Research in this laboratory has demonstrated that TCDD inhibits E2-induced responses in the rodent uterus and ...
Cheung, YL, Snelling, J, Mohammed, NND, Gray, TJB and Ioannides, C (1996) Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: Implications for their carcinogenicity ...
Genetic heterogeneity is widespread in tumors, but poorly documented in cell lines. According to immunoglobulin hypermutation analysis, the diffuse large B-cell lymphoma cell line U-2932 comprises two subpopulations faithfully representing original tumor subclones. We set out to identify molecular causes underlying subclone-specific expression affecting 221 genes including surface markers and the germinal center oncogenes BCL6 and MYC. Genomic copy number variations explained 58/221 genes differentially expressed in the two U-2932 clones. Subclone-specific expression of the aryl-hydrocarbon receptor (AhR) and the resulting activity of the AhR/ARNT complex underlaid differential regulation of 11 genes including MEF2B. Knock-down and inhibitor experiments confirmed that AhR/ARNT regulates MEF2B, a key transcription factor for BCL6. AhR, MEF2B and BCL6 levels correlated not only in the U-2932 subclones but in the majority of 23 cell lines tested, indicting overexpression of AhR as a novel mechanism ...
Genetic heterogeneity is widespread in tumors, but poorly documented in cell lines. According to immunoglobulin hypermutation analysis, the diffuse large B-cell lymphoma cell line U-2932 comprises two subpopulations faithfully representing original tumor subclones. We set out to identify molecular causes underlying subclone-specific expression affecting 221 genes including surface markers and the germinal center oncogenes BCL6 and MYC. Genomic copy number variations explained 58/221 genes differentially expressed in the two U-2932 clones. Subclone-specific expression of the aryl-hydrocarbon receptor and the resulting activity of the AhR/ARNT complex underlay differential regulation of 11 genes including MEF2B. Knock-down and inhibitor experiments confirmed that AhR/ARNT regulates MEF2B, key transcription factor for BCL6. AhR, MEF2B and BCL6 levels correlated not only in the U-2932 subclones but in the majority of 23 cell lines tested, indicting overexpression of AhR as novel mechanism behind ...
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the intracellular dioxin receptor mediate hypoxia and dioxin signalling, respectively. Both proteins are conditionally regulated basic helix-loop-helix (bHLH) transcription factors that, in addition to the bHLH motif, share a Per-Arnt-Sim (PAS) region of homology and form heterodimeric complexes with the common bHLH/PAS partner factor Arnt. Here we demonstrate that HIF-1 alpha required Arnt for DNA binding in vitro and functional activity in vivo. Both the bHLH and PAS motifs of Arnt were critical for dimerization with HIF-1 alpha. Strikingly, HIF-1 alpha exhibited very high affinity for Arnt in coimmunoprecipitation assays in vitro, resulting in competition with the ligand-activated dioxin receptor for recruitment of Arnt. Consistent with these observations, activation of HIF-1 alpha function in vivo or overexpression of HIF-1 alpha inhibited ligand-dependent induction of DNA binding activity by the dioxin receptor and dioxin receptor function ...
Hypoxia-inducible factor 1 alpha (HIF-1 alpha) and the intracellular dioxin receptor mediate hypoxia and dioxin signalling, respectively. Both proteins are conditionally regulated basic helix-loop-helix (bHLH) transcription factors that, in addition to the bHLH motif, share a Per-Arnt-Sim (PAS) region of homology and form heterodimeric complexes with the common bHLH/PAS partner factor Arnt. Here we demonstrate that HIF-1 alpha required Arnt for DNA binding in vitro and functional activity in vivo. Both the bHLH and PAS motifs of Arnt were critical for dimerization with HIF-1 alpha. Strikingly, HIF-1 alpha exhibited very high affinity for Arnt in coimmunoprecipitation assays in vitro, resulting in competition with the ligand-activated dioxin receptor for recruitment of Arnt. Consistent with these observations, activation of HIF-1 alpha function in vivo or overexpression of HIF-1 alpha inhibited ligand-dependent induction of DNA binding activity by the dioxin receptor and dioxin receptor function ...
The aryl hydrocarbon receptor (AHR) is critically involved in several physiologic processes, including cancer progression and multiple immune system activities. We, and others, have hypothesized that AHR modulators represent an important new class of targeted therapeutics. Here, ligand shape-based virtual modeling techniques were used to identify novel AHR ligands on the basis of previously identified chemotypes. Four structurally unique compounds were identified. One lead compound, 2-((2-(5-bromofuran-2-yl)-4-oxo-4H-chromen-3-yl)oxy)acetamide (CB7993113), was further tested for its ability to block three AHR-dependent biologic activities: triple-negative breast cancer cell invasion or migration in vitro and AHR ligand-induced bone marrow toxicity in vivo. CB7993113 directly bound both murine and human AHR and inhibited polycyclic aromatic hydrocarbon (PAH)- and TCDD-induced reporter activity by 75% and 90% respectively. A novel homology model, comprehensive agonist and inhibitor titration ...
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and its expression is influenced by environmental compounds, such as 3-methylcholanthrene (3-MC) and β-naphthoflavone (β-NF). AhR and its downstream genes, such as CYP1A1, are considered to play a pivotal role in xenobiotic responses. AhR signaling has also been proposed to mediate osteogenesis in experimental animals, but its details have remained unclear. Therefore, in this study, we examined the possible roles of AhR in human bone. Immunohistochemical analysis revealed that AhR was detected in both osteoblasts and osteoclasts. We then screened AhR-target genes using a microarray analysis in human osteoblastic hFOB cells. Results of microarray and subsequent PCR analysis did reveal that estrogen metabolizing and synthesizing enzymes, such as CYP1B1 and aromatase, were increased by 3-MC in hFOB and osteosarcoma cell line, MG-63. The subsequent antibody cytokine analysis also demonstrated that interleukin-1β and -6 expression
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that upon activation by the toxicant 2,3,7,8 tetrachlorodibenzo-p-dioxin (TCDD) stimulates gene expression and toxicity. AHR is also important for normal mouse physiology and may play a role in cancer progression in the absence of environmental toxicants. The objective of this report was to identify AHR-dependent genes (ADGs) whose expression is regulated by AHR in the absence of toxicants. RNA-Seq analysis revealed that AHR regulated the expression of over 600 genes at an FDR | 10% in MCF-7 breast cancer cells upon knockdown with short interfering RNA. Pathway analysis revealed that a significant number of ADGs were components of TCDD and tumor necrosis factor (TNF) pathways. We also demonstrated that siRNA knockdown of AHR modulated TNF induction of MNSOD and cytotoxicity in MCF-7 cells. Collectively, the major new findings of this report are: (1) endogenous AHR promotes the expression of xenobiotic metabolizing enzymes
Epithelia function as barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). However, AhR function in these tissues is unknown. Here we show that AhR regulates multiciliogenesis in both murine airway epithelia and in Xenopus laevis epidermis. In air-exposed airway epithelia, induction of factors required for multiciliogenesis, including cyclin O (Ccno) and Multicilin (Mcidas), is AhR dependent, and air exposure induces AhR binding to the Ccno promoter. Submersion and hypoxic conditions impede AhR-dependent Ccno induction. This is mediated by the persistence of Notch signalling, as Notch blockade renders multiciliogenesis and Ccno induction by AhR independent from air exposure. In contrast to Ccno induction, air exposure does not induce the canonical AhR target cytochrome P450 1a1 (Cyp1a1). Inversely, exposure to AhR ligands induces Cyp1a1 but not Ccno and impeded ciliogenesis. These data indicate that AhR involvement in detoxification of ...
GNF351 is a full aryl hydrocarbon receptor (AHR) antagonist. GNF351 competes with a photoaffinity AHR ligand for binding to the AHR with an IC50 of 62 nM. GNF351 is minimal toxicity in mouse or human keratinocytes. - Mechanism of Action & Protocol.
Page contains details about example of polymer-coated aryl hydrocarbon receptor transcription factor-binding ligand loaded magnetic nanoparticles . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
The findings suggest new modalities for cancer prevention and treatment A new Boston University School of Public Health (BUSPH) study has identified for the first time how the aryl hydrocarbon receptor (AhR), an environmental chemical receptor, drives immunosuppression in oral squamous cell carcinoma (OSCC)--and that its removal from malignant cells can result in tumor rejection.…
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AIP (aryl hydrocarbon receptor interacting protein), Authors: Sayka Barry, Márta Korbonits. Published in: Atlas Genet Cytogenet Oncol Haematol.
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Rabbit polyclonal Aryl hydrocarbon Receptor antibody validated for WB and tested in Human and Mouse. With 2 independent reviews. Immunogen corresponding to…
Preface. A. Historical background.. 1. History of Research on the AHR (Thomas A. Gasiewocz and Ellen C. Henry).. B. AHR as a ligand-activated transcription factor.. 2. Overview of AHR functional domains and the classical signaling pathway: induction of drug-metabolizing enzymes (Qiang Ma).. 3. Role of chaperone proteins in AHR function (Iain A. Murray and Gary H. Perdew).. 4. AHR Ligands: Promiscuity in Binding and Diversity in Response (Danica DeGroot, Guochun He, Domenico Fraccalvieri, Laura Bonati, Allesandro Pandin and Michael S. Denison).. 5. Dioxin response elements and regulation of gene transcription (Hollie Swanson).. 6. The AHR/ARNT dimer and transcriptional coactivators (Oliver Hankinson).. 7. Regulation of AHR by the AHR repressor (AHRR) (Yoshiaki Fujii-Kuriyama and Kaname Kawajiri).. 8. Influence of HIF-1α and Nrf2 signaling on AHR-mediated gene expression, toxicity and biological functions (Thomas Haarmann-Stemmann and Josef Abel).. 9. Functional interactions of AHR with other ...
Principal Investigator:ICHIHARA Sahoko, Project Period (FY):2006 - 2008, Research Category:Grant-in-Aid for Scientific Research (C), Section:一般, Research Field:Hygiene
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The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcriptional factor widely expressed among immune, epithelial, endothelial and stromal cells in barrier tissues.
Background Malignancy control cells (CSCs) possess increased level of resistance to cancers chemotherapy. possess been mystery, but right here we demonstrate it is definitely an aryl hydrocarbon receptor (AHR) agonist and this takes on a essential part. AHR is definitely a transcription element triggered by 2,3,7,8-tetrachlorodibenzo-value using the Cheng-Prussoff formula [55], where Kis the inhibition continuous for a medication (the contending ligand, i.elizabeth. tranilast or another non-labeled ligand): it represents the focus of the contending ligand in a competition assay which would take up 50% 2226-96-2 supplier of the receptors if no radioligand had been present. T is definitely the focus of free of charge radioligand utilized in the assay, and KD is definitely the dissociation continuous of the radioligand for the receptor. The Ki worth for a contending ligand is definitely an estimation of its presenting identified in an self-employed presenting or practical assay under related ...
Abstract Background Environmental toxicants, whose actions are often mediated through the aryl hydrocarbon receptor (AhR) pathway, pose risks to the health and well-being of exposed species, including humans. Of particular ...
Abstract Background Environmental toxicants, whose actions are often mediated through the aryl hydrocarbon receptor (AhR) pathway, pose risks to the health and well-being of exposed species, including humans. Of particular ...
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Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene. This gene encodes a ... "Entrez Gene: ARNT2 aryl-hydrocarbon receptor nuclear translocator 2". Human ARNT2 genome location and ARNT2 gene details page ... 2003). "Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate ... A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, ...
Aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL) or Brain and Muscle ARNT-Like 1 (BMAL1) is a protein that ... "ARNTL aryl hydrocarbon receptor nuclear translocator-like [ Homo sapiens (human) ]". National Center for Biotechnology ... Human Aryl hydrocarbon receptor nuclear translocator-like protein 1) at the PDBe-KB. Overview of all the structural information ... "Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 ...
تعرف SIM1 has been shown to interact with Aryl hydrocarbon receptor nuclear translocator. GRCh38: Ensembl release 89: ... homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator ... homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator ... Yamaki A, Kudoh J, Shimizu N, Shimizu Y (Jan 2004). "A novel nuclear localization signal in the human single-minded proteins ...
... has been shown to interact with aryl hydrocarbon receptor nuclear translocator and ARNTL. GRCh38: Ensembl release 89: ... Luo JC, Shibuya M (March 2001). "A variant of nuclear localization signal of bipartite-type is required for the nuclear ... and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1)". The Journal of ...
Aryl hydrocarbon receptor nuclear translocator-like 2, also known as Mop9, Bmal2, Clif, or Arntl2, is a gene. Arntl2 is a ... Aryl hydrocarbon receptor nuclear translocator-like protein 2) at the PDBe-KB. v t e. ...
... to some specific Down syndrome phenotypes SIM2 has been shown to interact with Aryl hydrocarbon receptor nuclear translocator. ... homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator ... homologs of the Drosophila single-minded protein that interact with the mouse aryl hydrocarbon receptor nuclear translocator ... Yamaki A, Kudoh J, Shimizu N, Shimizu Y (Jan 2004). "A novel nuclear localization signal in the human single-minded proteins ...
"Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct ... putative cofactor TIF1alpha is a protein kinase that is hyperphosphorylated upon interaction with liganded nuclear receptors". ...
"Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct ... McEwan IJ, Gustafsson J (1997). "Interaction of the human androgen receptor transactivation function with the general ...
Bmal1 - Bmal1 also known as ARNTL or Aryl hydrocarbon receptor nuclear translocator-like, encodes a protein that forms a ... This is caused by two nuclear receptors, REV-ERB and ROR, which suppresses and activates Bmal1 transcription, respectively. In ...
... and the aryl hydrocarbon receptor nuclear translocator (Arnt), the beta subunit. HIF1A contains a basic helix-loop-helix domain ... The HIF1A polypeptide also contains a nuclear localization signal motif, two transactivating domains CTAD and NTAD, and an ... role of vascular endothelial growth factor and its receptors". Surgical Oncology Clinics of North America. 10 (2): 339-56, ix. ... HIF1 alpha and adenosine receptors". Nature Reviews. Immunology. 5 (9): 712-21. doi:10.1038/nri1685. PMID 16110315. S2CID ...
... aryl hydrocarbon receptor nuclear translocator protein Sim - single-minded protein Since the initial discovery of the PAS ...
... and the aryl hydrocarbon receptor nuclear translocator. In the intestine, but not the liver, CYP1A1 expression moreover depends ... CYP1A1 is also known as AHH (aryl hydrocarbon hydroxylase). It is involved in the metabolic activation of aromatic hydrocarbons ... is regulated by a heterodimeric transcription factor that consist of the aryl hydrocarbon receptor, a ligand activated ... Kiyohara C, Hirohata T, Inutsuka S (Jan 1996). "The relationship between aryl hydrocarbon hydroxylase and polymorphisms of the ...
... may refer to: Aryl hydrocarbon receptor nuclear translocator, a human gene Lipid IVA 4-amino-4-deoxy-L- ...
... aryl hydrocarbon receptor nuclear translocator) and then binds xenobiotic response elements (XREs) in DNA located upstream of ... aryl hydrocarbon receptor) in the cytosol. Upon binding the transformed receptor translocates to the nucleus where it dimerises ... Intestinal, but not hepatic, expression of CYP1A1 depends on TOLL-like receptor 2 (TLR2), which is a eukaryotic receptor for ... BaP diminished NMDA receptor-dependent nerve cell activity measured as mRNA expression of the NMDA NR2B receptor subunit. BaP ...
... aryl hydrocarbon receptor nuclear translocator MeSH D12.776.930.125.625.750 - hypoxia-inducible factor 1, alpha subunit MeSH ... estrogen receptor alpha MeSH D12.776.930.682.350.262 - estrogen receptor beta MeSH D12.776.930.682.350.350 - receptors, ... hepatocyte nuclear factor 3-beta MeSH D12.776.930.977.249.875 - hepatocyte nuclear factor 3-gamma The list continues at List of ... retinoid X receptor alpha MeSH D12.776.930.675.500.625 - retinoid X receptor beta MeSH D12.776.930.675.500.750 - retinoid X ...
... the latter being a constitutively-expressed aryl hydrocarbon receptor nuclear translocator (ARNT). HIF-1 belongs to the PER- ... an overview of all the structure information available in the PDB for Human Aryl hydrocarbon receptor nuclear translocator PDBe ... It was shown that NF-κB (nuclear factor κB) is a direct modulator of HIF-1α expression in the presence of normal oxygen ...
... aryl hydrocarbon receptor nuclear translocator MeSH D12.776.260.103.625.750 - hypoxia-inducible factor 1, alpha subunit MeSH ... hepatocyte nuclear factor 3-beta MeSH D12.776.260.950.249.875 - hepatocyte nuclear factor 3-gamma The list continues at List of ... hepatocyte nuclear factor 1-alpha MeSH D12.776.260.262.500.750 - hepatocyte nuclear factor 1-beta MeSH D12.776.260.400.249.249 ... hepatocyte nuclear factor 6 MeSH D12.776.260.522.750.249 - sp1 transcription factor MeSH D12.776.260.522.750.500 - sp2 ...
... brain and muscle aryl hydrocarbon receptor nuclear translocator (ARNT)-like 1) is the primary homolog of Drosophila CYC. Three ... suggesting that melatonin receptors present in the SCN mediate phase-shifting effects through the SCN.[citation needed] ...
"Role of the aryl hydrocarbon receptor nuclear translocator protein in aryl hydrocarbon (dioxin) receptor action". Molecular ... p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator ... and in AhR's dimerization partner the aryl hydrocarbon receptor nuclear translocator (ARNT). The PAS domains support specific ... "The aryl hydrocarbon receptor interacts with estrogen receptor alpha and orphan receptors COUP-TFI and ERRalpha1". Archives of ...
... peroxisome proliferator-activated receptor alpha and the aryl hydrocarbon receptor nuclear translocator. Further, it has shown ... AH receptor-interacting protein (AIP) also known as aryl hydrocarbon receptor-interacting protein, immunophilin homolog ARA9, ... "Entrez Gene: AIP aryl hydrocarbon receptor interacting protein". Kuzhandaivelu N, Cong YS, Inouye C, Yang WM, Seto E (December ... 2015). "Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I ...
... p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator ... is a coactivator of the androgen receptor". Cancer Res. 60 (21): 5946-9. PMID 11085509. nuclear receptor coactivator 2 at the ... The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is ... Hence, NCOA2 assists nuclear receptors in the upregulation of DNA expression. GRIP1 is a transcriptional co-activator of the ...
... in conjunction with the receptor's binding partner, aryl hydrocarbon receptor nuclear translocator (ARNT). The protein encoded ... "Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear ... The aryl-hydrocarbon receptor repressor also known as AHRR is a human gene. Dioxins and dioxin-like compounds are teratogens ... Kanno Y, Takane Y, Izawa T, Nakahama T, Inouye Y (June 2006). "The Inhibitory Effect of Aryl Hydrocarbon Receptor Repressor ( ...
... p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator ... Aryl hydrocarbon receptor,[7] PDE6G,[8] STAT1,[9][10] EPH receptor B2,[11][12] Androgenski receptor,[13][14][15] Proteinska ... Estrogenski receptor alfa,[13][31][32][33] Estrogenski receptor beta,[13][33] HNF1A,[34] KHDRBS1,[35][36][37][38][39] DDEF1,[40 ... Lee, S K; Jung S Y, Kim Y S, Na S Y, Lee Y C, Lee J W (February 2001). "Two distinct nuclear receptor-interaction domains and ...
"Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast ... "Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast ... "Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct ... p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator ...
... adenine nucleotide translocator 3 MeSH D12.776.157.530.750.100 - aryl hydrocarbon receptor nuclear translocator MeSH D12.776. ... nuclear cap-binding protein complex MeSH D12.776.157.905.500.249 - bacterial transferrin receptor complex MeSH D12.776.157.905. ... u2 small nuclear MeSH D12.776.157.725.500.875.615 - ribonucleoprotein, u4-u6 small nuclear MeSH D12.776.157.725.500.875.620 - ... tnf receptor-associated factor 1 MeSH D12.776.157.057.500.750 - tnf receptor-associated factor 2 MeSH D12.776.157.057.500.875 ...
... adenine nucleotide translocator 3 MeSH D12.776.543.585.750.100 - aryl hydrocarbon receptor nuclear translocator MeSH D12.776. ... receptor, erbb-2 MeSH D12.776.543.750.060.437 - receptor, erbb-3 MeSH D12.776.543.750.060.468 - receptor, igf type 1 MeSH ... receptor, igf type 1 MeSH D12.776.543.750.750.400.780.410 - receptor, igf type 2 MeSH D12.776.543.750.750.400.820 - receptors, ... receptor, trkb MeSH D12.776.543.750.060.499 - receptor, trkc MeSH D12.776.543.750.060.500 - receptors, eph family MeSH D12.776. ...
... aryl hydrocarbon receptor nuclear translocator) and then binds xenobiotic response elements (XREs) in DNA located upstream of ... aryl hydrocarbon receptor) in the cytosol.[28] Upon binding the transformed receptor translocates to the nucleus where it ... expression of CYP1A1 depends on TOLL-like receptor 2 (TLR2),[30] which is a eucaryotic receptor for bacterial surface ... Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon found in coal tar with the formula C20H12. The compound is one of the ...
... aryl hydrocarbon hydroxylases MeSH D12.776.422.220.453.040.050 - aniline hydroxylase MeSH D12.776.422.220.453.040.110 - ... receptor, erbb-2 MeSH D12.776.624.664.700.790 - receptor, erbb-3 MeSH D12.776.624.664.700.800 - receptor, macrophage colony- ... u2 small nuclear MeSH D12.776.664.962.500.875.615 - ribonucleoprotein, u4-u6 small nuclear MeSH D12.776.664.962.500.875.620 - ... adenine nucleotide translocator 1 MeSH D12.776.575.750.500.200 - adenine nucleotide translocator 2 MeSH D12.776.575.750.500.300 ...
... aryl hydrocarbon receptor nuclear translocator) and then binds xenobiotic response elements (XREs) in DNA located upstream of ... aryl hydrocarbon receptor) in the cytosol.[31] Upon binding the transformed receptor translocates to the nucleus where it ... BaP diminished NMDA receptor-dependent nerve cell activity measured as mRNA expression of the NMDA NR2B receptor subunit.[12] ... expression of CYP1A1 depends on TOLL-like receptor 2 (TLR2),[33] which is a eukaryotic receptor for bacterial surface ...
"Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast ... "Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast ... "Trans-activation by the human aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator proteins: direct ... p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator ...
Arntl2 aryl hydrocarbon receptor nuclear translocator-like 2 [Mus musculus] Arntl2 aryl hydrocarbon receptor nuclear ... aryl hydrocarbon receptor nuclear translocator-like 2provided by MGI. Primary source. MGI:MGI:2684845 See related. Ensembl: ... aryl hydrocarbon receptor nuclear translocator-like protein 2. Names. brain and muscle ARNT-like 2. brain-muscle-ARNT-like ... Arntl2 aryl hydrocarbon receptor nuclear translocator-like 2 [ Mus musculus (house mouse) ] Gene ID: 272322, updated on 10-Oct- ...
Aryl hydrocarbon receptor nuclear t.... Aryl hydrocarbon receptor nuclear translocator 2, ARNT protein 2 (Class E basic helix- ... Aryl hydrocarbon receptor nuclear translocator 2Imported. ,p>Information which has been imported from another database using ... tr,H0YKW1,H0YKW1_HUMAN Aryl hydrocarbon receptor nuclear translocator 2 (Fragment) OS=Homo sapiens OX=9606 GN=ARNT2 PE=1 SV=1 ... Aryl hydrocarbon receptor nuclear translocator 2. HUMAN. 717. aryl hydrocarbon receptor nuclear translocator isoform X3. PERMB ...
Aryl hydrocarbon receptor nuclear translocator 2Imported. Automatic assertion inferred from database entriesi ... tr,K7B2L7,K7B2L7_PANTR Aryl hydrocarbon receptor nuclear translocator 2 OS=Pan troglodytes OX=9598 GN=ARNT2 PE=2 SV=1 ... Aryl hydrocarbon receptor nuclear translocator 2. HUMAN. 717. aryl hydrocarbon receptor nuclear translocator isoform X3. PERMB ... Aryl hydrocarbon receptor nuclear translocator 2. HUMAN. 717. UniRef90_Q9HBZ2. Aryl hydrocarbon receptor nuclear translocator 2 ...
... aryl hydrocarbon receptor nuclear translocator), Authors: Oliver Hankinson. Published in: Atlas Genet Cytogenet Oncol Haematol ... ARNT (aryl hydrocarbon receptor nuclear translocator). Written. 2004-10. Oliver Hankinson. UCLA Medical Center, Center for the ... Variability of the human aryl hydrocarbon receptor nuclear translocator (ARNT) gene.. Scheel J, Hussong R, Schrenk D, Schmitz ... The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT- ...
Receptors, Aryl Hydrocarbon / genetics * Receptors, Aryl Hydrocarbon / physiology* * Transcription Factors / genetics * ... Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated ... and arylhydrocarbon receptor nuclear translocator (Arnt) genes in a VHL mouse model of cavernous liver hemangiomas and ...
Overexpression of the aryl hydrocarbon receptor nuclear translocator partially rescues fetoplacental angiogenesis in severe ... Previous studies have shown that aryl hydrocarbon receptor nuclear translocator (ARNT) is a key mediator of proper placental ... Shuhan Ji, Hong Xin, Emily J. Su; Overexpression of the aryl hydrocarbon receptor nuclear translocator partially rescues ...
Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in ... Aryl hydrocarbon receptor nuclear translocator promotes the proliferation and invasion of clear cell renal cell carcinoma cells ... Zhao Y, Han F, Zhang X, Zhou C and Huang D: Aryl hydrocarbon receptor nuclear translocator promotes the proliferation and ... Mandl M and Depping R: Hypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1β): Is it a rare exception ...
Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and ... Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and ...
ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) regulates beta-cell function, and potentially survival. Lack of ARNT ... ARNT also partners HIF-2alpha and AhR (aryl hydrocarbon receptor) to form active transcriptional complexes, and further work to ... ARNT also partners HIF-2alpha and AhR (aryl hydrocarbon receptor) to form active transcriptional complexes, and further work to ... ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) regulates beta-cell function, and potentially survival. Lack of ARNT ...
Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) is required for HIF-2alpha transcriptional activity and has previously ... Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) is required for HIF-2alpha transcriptional activity and has previously ... Hepatocyte- specific deletion of ARNT (aryl hydrocarbon receptor nuclear translocator) results in altered fibrotic gene ... Hepatocyte- specific deletion of ARNT (aryl hydrocarbon receptor nuclear translocator) results in altered fibrotic gene ...
aryl hydrocarbon receptor. ANOVA. analysis of variance. ARNT. aryl hydrocarbon receptor nuclear translocator. DEX. ... Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and ... Receptor and Pregnane X Receptor in Dexamethasone Induction of Rat Hepatic Aryl Hydrocarbon Receptor Nuclear Translocator and ... 2012) Aryl hydrocarbon receptor nuclear translocator in human liver is regulated by miR-24. Toxicol Appl Pharmacol 260:222-231. ...
A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, ... ARNT2; aryl-hydrocarbon receptor nuclear translocator 2; aryl hydrocarbon receptor nuclear translocator 2; bHLHe1; KIAA0307; ... A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, ... aryl hydrocarbon receptor binding, protein heterodimerization activity. Some of the functions are cooperated with other ...
This protein complex is composed of two subunits, HIF-1alpha and -1beta (aryl hydrocarbon receptor nuclear translocator, ARNT ... Hepatic Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) regulates metabolism in mice. *Christopher H Scott, Kuan-Minn Cha ... Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia.. @article{ ... This protein complex is composed of two subunits, HIF-1alpha and -1beta (aryl hydrocarbon receptor nuclear translocator, ARNT ...
Levine, Steven L. ; Perdew, Gary H. / Aryl hydrocarbon receptor (AHR)/AhR nuclear translocator (ARNT) activity is unaltered by ... Aryl hydrocarbon receptor (AHR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/ ... Levine, S. L., & Perdew, G. H. (2001). Aryl hydrocarbon receptor (AHR)/AhR nuclear translocator (ARNT) activity is unaltered by ... Aryl hydrocarbon receptor (AHR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/ ...
"Aryl Hydrocarbon Receptor Nuclear Translocator" by people in this website by year, and whether "Aryl Hydrocarbon Receptor ... Aryl Hydrocarbon Receptor Nuclear Translocator*Aryl Hydrocarbon Receptor Nuclear Translocator. *AhR Nuclear Translocator ... Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with ... "Aryl Hydrocarbon Receptor Nuclear Translocator" is a descriptor in the National Library of Medicines controlled vocabulary ...
Aryl hydrocarbon receptor nuclear translocator) ELISA Kit. $410.00. Mouse Arnt(Aryl hydrocarbon receptor nuclear translocator) ... Home / Quantitative Biomarker Assays / Mouse / Mouse Arnt(Aryl hydrocarbon receptor nuclear translocator) ELISA Kit. ...
Aryl Hydrocarbon Receptor Nuclear Translocator, including: function, proteins, disorders, pathways, orthologs, and expression. ... aryl hydrocarbon receptor nuclear translocator,dioxin receptor translocator,constituvely expressed for activation of genes ... The aryl hydrocarbon receptor nuclear translocator gene polymorphism in patients with recurrent miscarriage. (PMID: 16364012) ... ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) is a Protein Coding gene. Diseases associated with ARNT include Hypoxia. ...
Single nucleotide polymorphisms in the human aryl hydrocarbon receptor nuclear translocator (ARNT) gene. Drug Metab ... in genes associated with aryl hydrocarbon receptor (AHR)-regulated pathways may result in greater susceptibility to DLC ... A key step in the activation of AHR involves heterodimerization with the AHR nuclear translocator (ARNT) protein before binding ...
Aryl Hydrocarbon Receptor Nuclear Translocator 2, including: function, proteins, disorders, pathways, orthologs, and expression ... Aryl hydrocarbon receptor nuclear translocator 2. Protein Accession:. Q9HBZ2. Secondary Accessions: *B4DIS7 ... ARNT2 (Aryl Hydrocarbon Receptor Nuclear Translocator 2) is a Protein Coding gene. Diseases associated with ARNT2 include Webb- ... Aryl hydrocarbon receptor nuclear translocator 2 (ARNT2): structure, gene mapping, polymorphisms, and candidate evaluation for ...
This heterodimer also activates nuclear receptors NR1D1/2 and RORA/B/G, which form a second feedback loop and which activate ... Part of a nuclear complex which also includes RACK1 and PRKCA; RACK1 and PRKCA are recruited to the complex in a circadian ... for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL/BMAL1 (By similarity). ...
Human ARNT(Aryl hydrocarbon receptor nuclear translocator) ELISA Kit XpressBio *. Detection Target: ARNT ...
aryl hydrocarbon receptor nuclear translocator;. GLUT3,. glucose transporter-3;. VEGF,. vascular endothelial growth factor;. wt ... in which it is termed the aryl hydrocarbon receptor nuclear translocator), we also studied c31 cells, which have a different ... where it was termed the aryl hydrocarbon receptor nuclear translocator (ARNT) (15). Mutant cell lines with a defective ... but HIF-1β had already been recognized as the dimerization partner of the aryl hydrocarbon receptor in the xenobiotic response ...
Analysis of aryl hydrocarbon receptor nuclear translocator (ARNT) protein expression and concentration in aquatic and mammalian ... Analysis of aryl hydrocarbon receptor nuclear translocator (ARNT) protein expression and concentration in aquatic and mammalian ... Post a Comment for Analysis of aryl hydrocarbon receptor nuclear translocator (ARNT) protein expression and concentration in ... Add tags for Analysis of aryl hydrocarbon receptor nuclear translocator (ARNT) protein expression and concentration in aquatic ...
The aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) are mediators of many of the ... Analysis of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) in signal transduction ... Analysis of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) in signal transduction ... Post a Comment for Analysis of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) in ...
Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal ... Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal ... Aryl-Hydrocarbon-Receptor-Nuclear-Translocator-Like (ARNTL/BMAL1) is a circadian clock-regulated transcription factor promoting ... Nuclear-Receptor-Subfamily-1-Group-D-Member-1 (NR1D1/REVERBA) bound a - 672 bp Retinoic-Acid-Receptor-Related-Orphan-Receptor- ...
One partner, HIF-1beta, had been recognized previously as the aryl hydrocarbon receptor nuclear translocator (ARNT), an ... Animals, Aryl Hydrocarbon Receptor Nuclear Translocator, Base Sequence, Cell Hypoxia, Cell Nucleus, DNA-Binding Proteins, ... The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT- ... The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. Studies in ARNT- ...
Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and ... Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and ... Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and ... Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and ...
The transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT), also designated as Hypoxia-inducible factor ( ... From: The expression level of the transcription factor Aryl hydrocarbon receptor nuclear translocator (ARNT) determines ...
Aryl hydrocarbon receptor nuclear translocator. ATP:. Adenosine triphosphate. BKV:. BK virus. BL:. Burkitt lymphoma. ... G.-X. Ruan and A. Kazlauskas, "Lactate engages receptor tyrosine kinases Axl, Tie2, and vascular endothelial growth factor ... Journal of Nuclear Medicine, vol. 49, supplement 2, pp. 24S-42S, 2008. View at Publisher · View at Google Scholar ... KSHV-encoded latency associated nuclear antigen LANA either induces CD147 directly, binding to gene promoter, or transactivates ...
  • The ARNT gene encodes the aryl hydrocarbon receptor nuclear translocator protein that forms a complex with ligand-bound aryl hydrocarbon receptor (AhR), and is required for receptor function. (wikipedia.org)
  • ARNT is a nuclear protein in most cell types, although it may also be located in the cytosol, particularly during embryogenesis. (atlasgeneticsoncology.org)
  • ARNT serves as the dimerization partner for a number of other bHLH-PAS proteins, whose activity is modulated either by exogenous chemicals (the aryl hydrocarbon receptor ( AHR )), or by hypoxia (hypoxia inducible factors 1,2 and 3 alpha [ HIF-1a , HIF-2a and HIF-3a), or which show restricted expression (e.g. (atlasgeneticsoncology.org)
  • The AHR/ARNT dimer and ARNT itself can also impact signaling by the eostrogen receptor. (atlasgeneticsoncology.org)
  • In order to examine the role of HIF in von Hippel-Lindau (VHL)-associated vascular tumorigenesis, we utilized Cre-loxP-mediated recombination to inactivate hypoxia-inducible factor-1alpha (Hif-1alpha) and arylhydrocarbon receptor nuclear translocator (Arnt) genes in a VHL mouse model of cavernous liver hemangiomas and polycythemia. (nih.gov)
  • Previous studies have shown that aryl hydrocarbon receptor nuclear translocator (ARNT) is a key mediator of proper placental angiogenesis, and within placental endothelial cells (ECs) from human FGRadv pregnancies, low expression of ARNT leads to decreased vascular endothelial growth factor A (VEGFA) expression and deficient tube formation. (portlandpress.com)
  • Aryl hydrocarbon receptor nuclear translocator (ARNT) is a transcription factor that has been reported to play a vital role in regulating glycolysis, angiogenesis and apoptosis. (spandidos-publications.com)
  • Chilov D, Camenisch G, Kvietikova I, Ziegler U, Gassmann M and Wenger RH: Induction and nuclear translocation of hypoxia-inducible factor-1 (HIF-1): Heterodimerization with ARNT is not necessary for nuclear accumulation of HIF-1alpha. (spandidos-publications.com)
  • Mandl M and Depping R: Hypoxia-inducible aryl hydrocarbon receptor nuclear translocator (ARNT) (HIF-1β): Is it a rare exception? (spandidos-publications.com)
  • ARNT (Aryl hydrocarbon Receptor Nuclear Translocator) regulates beta-cell function, and potentially survival. (garvan.org.au)
  • ARNT also partners HIF-2alpha and AhR (aryl hydrocarbon receptor) to form active transcriptional complexes, and further work to understand the roles of HIF-2alpha and AhR in transplant outcomes is needed. (garvan.org.au)
  • Aryl hydrocarbon Receptor Nuclear Translocator (ARNT) is required for HIF-2alpha transcriptional activity and has previously been shown to regulate hepatic metabolism in mice. (garvan.org.au)
  • The aryl hydrocarbon receptor (AHR) nuclear translocator (ARNT), as the AHR's heterodimerization partner, and NADPH-cytochrome P450 oxidoreductase (POR), as the key electron donor for all microsomal P450s, are independent and indispensable components in the adaptive and toxic responses to polycyclic aromatic hydrocarbons. (aspetjournals.org)
  • Expression of both ARNT and POR in rat liver is induced by dexamethasone (DEX), a synthetic glucocorticoid known to activate both the glucocorticoid receptor (GR) and the pregnane X receptor (PXR). (aspetjournals.org)
  • This protein complex is composed of two subunits, HIF-1alpha and -1beta (aryl hydrocarbon receptor nuclear translocator, ARNT). (semanticscholar.org)
  • Levine, SL & Perdew, GH 2001, ' Aryl hydrocarbon receptor (AHR)/AhR nuclear translocator (ARNT) activity is unaltered by phosphorylation of a periodicity/ARNT/single-minded (PAS)-region serine residue ', Molecular pharmacology , vol. 59, no. 3, pp. 557-566. (elsevier.com)
  • N2 - The aryl hydrocarbon nuclear translocator (ARNT) protein belongs to the family of basic helix-loop-helix (HLH)-periodicity/ ARNT/single-minded [Per/ARNT/Sim (PAS)] transcription factors and regulates a range of cellular processes by either homodimerizing or heterodimerizing with other basic HLH-PAS proteins. (elsevier.com)
  • To date, it has been shown that both the HLH and PAS domains are required for aryl hydrocarbon receptor (AhR) ARNT heterodimerization and that phosphorylation of ARNT is also required for this heterodimerization. (elsevier.com)
  • ARNT (Aryl Hydrocarbon Receptor Nuclear Translocator) is a Protein Coding gene. (genecards.org)
  • A key step in the activation of AHR involves heterodimerization with the AHR nuclear translocator (ARNT) protein before binding to its DNA response element. (toxstrategies.com)
  • HIF-1α was a newly described protein, but HIF-1β had already been recognized as the dimerization partner of the aryl hydrocarbon receptor in the xenobiotic response, where it was termed the aryl hydrocarbon receptor nuclear translocator (ARNT) ( 15 ). (pnas.org)
  • Analysis of aryl hydrocarbon receptor nuclear translocator (ARNT) protein expression and concentration in aquatic and mammalian models by Jennifer L. Holmes. (musc.edu)
  • Analysis of aryl hydrocarbon receptor nuclear translocator (ARNT) protein expression and. (musc.edu)
  • Post a Comment for Analysis of aryl hydrocarbon receptor nuclear translocator (ARNT) protein expression and concentration in aquatic and mammalian models by Jennifer L. Holmes. (musc.edu)
  • The aryl hydrocarbon receptor (AHR) and the aryl hydrocarbon receptor nuclear translocator (ARNT) are mediators of many of the biologic and toxic effects of halogenated aromatic hydrocarbons . (musc.edu)
  • Basal levels of ARNT were not affected by hypoxia in any cell line and remained exclusively nuclear . (musc.edu)
  • The role of the aryl hydrocarbon receptor nuclear translocator (ARNT) in hypoxic induction of gene expression. (nihr.ac.uk)
  • One partner, HIF-1beta, had been recognized previously as the aryl hydrocarbon receptor nuclear translocator (ARNT), an essential component of the xenobiotic response. (nihr.ac.uk)
  • Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediat. (cdc.gov)
  • Aryl hydrocarbon receptor nuclear translocator (ARNT) gene as a positional and functional candidate for type 2 diabetes and prediabetic intermediate traits: Mutation detection, case-control studies, and gene expression analysis. (cdc.gov)
  • Several studies have revealed that virtually all major toxic effects of dioxins are mediated by the specific binding of TCDD to a cytosolic protein, the aryl hydrocarbon receptor (AHR), which, upon ligand binding, translocates into the nucleus and heterodimerizes with the ARNT protein. (mcponline.org)
  • In addition to a series of studies showing interaction of the AHR-ARNT heterodimer with the estrogen receptor ( 8 , 9 ) a novel response element (called the AHRE-II) has been characterized recently. (mcponline.org)
  • The involvement of the aryl hydrocarbon receptor (AHR) and aryl hydrocarbon nuclear translocator (ARNT) in mediating the effects of oltipraz on the XRE is supported by electrophoretic mobility supershift data and AHR/ARNT overexpression studies. (aspetjournals.org)
  • Aryl hydrocarbon receptor nuclear translocator (ARNT) is a member of the basic helix-loop-helix Per/ARNT/Sim (bHLH-PAS) proteins and serves as a binding partner for a number of other family members. (ahajournals.org)
  • Four of the most differentially expressed genes between the benign and in vitro malignant rat mammary cell lines are tumor protein translationally controlled I (TPTI), aryl hydrocarbon receptor nuclear translocator (ARNT), ataxia telangiectasia mutated (ATM) and RAN GTPase (RAN). (biomedcentral.com)
  • The AHR works in concert with a related protein, the aryl hydrocarbon receptor nuclear translocator (ARNT). (whoi.edu)
  • Should the Human Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) ELISA Kit is proven to show malperformance, you will receive a refund or a free replacement. (bd-ibr.org)
  • Description: A sandwich quantitative ELISA assay kit for detection of Human Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in samples from tissue homogenates, cell lysates or other biological fluids. (bd-ibr.org)
  • Dioxin and other aryl hydrocarbons bind to the PAS domain of Ahr, causing Ahr to translocate to the nucleus, where it dimerizes with another bHLH-PAS protein, the aryl hydrocarbon receptor nuclear translocator (Arnt). (biologists.org)
  • Ahr:Arnt heterodimers then activate transcription of target genes that encode enzymes involved in metabolizing aryl hydrocarbons. (biologists.org)
  • After binding ligand, Ahr dimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) protein, and the dimer upregulates the transcription of Cyp1a1, Cyp1b1 and other enzymes involved in the metabolic activation of B[ a ]P. Arnt null mice die in utero . (scialert.net)
  • A highly similar protein in mouse forms functional complexes with both aryl hydrocarbon receptors and Single-minded proteins, suggesting addition roles for the encoded protein in the metabolism of xenobiotic compounds and the regulation of neurogenesis, respectively. (creativebiomart.net)
  • NK cells basally expressed the AHR, relevant chaperone proteins, and the AHR nuclear translocator, which heterodimerizes with the AHR to form a competent transcription factor. (jimmunol.org)
  • In the present study, we induced DME expression in labeled mice through synchronous ligand-mediated activation of multiple upstream nuclear receptors, thereby enhancing signals for proteins including Cyps 1a, 2a, 2b, 2c, and 3a. (mcponline.org)
  • The codependency for PER and TIM in maintaining this transcriptional feedback loop is at least partly based on the fact that these two proteins form a heterodimeric partnership in the cytoplasm that appears necessary for nuclear entry of both subunits ( 14 , 29 , 34 , 40 , 51 , 61 , 64 ). (asm.org)
  • 1997 ) A nuclear localization signal of human aryl hydrocarbon receptor nuclear translocator/hypoxia-inducible factor 1 b is a novel bipartite type recognized by the two components of nuclear pore-targeting complex. (biologists.org)
  • Binding of ligand, which includes dioxin and polycyclic aromatic hydrocarbons, results in translocation of the ligand-binding subunit only into the nucleus. (wikipedia.org)
  • Aryl hydrocarbon receptor nuclear translocator is a basic HELIX-LOOP-HELIX MOTIF containing protein that forms a complex with DIOXIN RECEPTOR. (uchicago.edu)
  • Required for activity of the Ah (dioxin) receptor. (genecards.org)
  • In the case of dioxin-like compounds (DLCs), it has been hypothesized that single nucleotide polymorphisms (SNPs) in genes associated with aryl hydrocarbon receptor (AHR)-regulated pathways may result in greater susceptibility to DLC toxicity. (toxstrategies.com)
  • 2,3,7,8-Tetrachlorodibenzo- p -dioxin (TCDD) 1 is considered to be one of the most potent toxicants known and is the prototypical representative of the polyhalogenated aromatic hydrocarbon class of persistent environmental contaminants. (mcponline.org)
  • 1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
  • ss is the closest known homolog of the mammalian aryl hydrocarbon receptor (Ahr), also known as the dioxin receptor. (biologists.org)
  • 1988 ) Association of the dioxin receptor with the Mr 90,000 heat shock protein: a structural kinship with the glucocorticoid receptor. (biologists.org)
  • 1988 ) The DNA recognition site for the dioxin-Ah receptor complex. (biologists.org)
  • 1998 ) Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia , a homolog of the mammalian dioxin receptor. (biologists.org)
  • This heterodimer also activates nuclear receptors NR1D1 /2 and RORA /B/G, which form a second feedback loop and which activate and repress ARNTL /BMAL1 transcription, respectively. (rcsb.org)
  • Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal cancer via regulation of vascular endothelial growth factor A. (rcsi.com)
  • Aryl-Hydrocarbon-Receptor-Nuclear-Translocator-Like (ARNTL/BMAL1) is a circadian clock-regulated transcription factor promoting expression of genes involved in angiogenesis and tumour progression. (rcsi.com)
  • Mechanistically, Nuclear-Receptor-Subfamily-1-Group-D-Member-1 (NR1D1/REVERBA) bound a - 672 bp Retinoic-Acid-Receptor-Related-Orphan-Receptor-Alpha-responsive-element (RORE) adjacent to a BMAL1 DNA-binding motif (E-box) in the VEGFA gene promoter, resulting in increased VEGFA synthesis and proliferation of human CRC cell lines. (rcsi.com)
  • Aryl hydrocarbon receptor nuclear translocator-like (also known as BMAL1) and its target D site-binding protein (DBP) are both pivotal transcription factors of the circadian core clock. (springer.com)
  • The current molecular model for the circadian clock is based on a transcriptional feedback loop in which aryl hydrocarbon receptor nuclear translocator-like (BMAL1)/clock circadian regulator (CLOCK) heterodimers drive the transcription of cryptochrome 1 and 2 ( Cry1 and Cry2 ) and period circadian clock 1, 2 and 3 ( Per1 , Per2 and Per3 ) by binding to the E-boxes on their promoters. (springer.com)
  • PA1-523 detects BMAL1/aryl hydrocarbon nuclear translocator 3 (ARNT3) from hamster and mouse tissues as well as recombinant human BMAL1. (thermofisher.com)
  • These findings show that nuclear export and degradation of AHR are two additional steps in the AHR-mediated pathway . (musc.edu)
  • One approach involves development of a spatial, multicellular "virtual tissue" model of the liver lobule that combines molecular circuits in individual hepatocytes with cell-cell interactions and blood-mediated transport of toxicants through hepatic sinusoids, to enable quantitative, mechanistic prediction of hepatic dose-response for activation of the aryl hydrocarbon receptor toxicity pathway. (frontiersin.org)
  • SRC3 has an important role in promoting breast tumour cell proliferation, migration, invasion and metastasis through many mechanisms, such as increasing the function of oestrogen receptor-α and E2F1, the activity of the insulin-like growth factor 1 (IGF1) signalling pathway, epidermal growth factor receptor (EGFR) and ERBB2, and the expression of MMPs. (nature.com)
  • ARNT2 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding, aryl hydrocarbon receptor binding, protein heterodimerization activity. (creativebiomart.net)
  • Aryl hydrocarbon receptor nuclear translocator 2 is a protein that in humans is encoded by the ARNT2 gene. (wikipedia.org)
  • Expression of a series of Ah receptor (AhR) deletion mutants in an in vitro translation system has been previously used to map several functional domains of the murine AhR (Dolwick et al. (nih.gov)
  • 1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)
  • Much of our research has focused on the halogenated aromatic hydrocarbons (HAHs), a group of chemicals that includes the chlorinated dibenzo- p -dioxins, polychlorinated biphenyls (PCBs), halogenated diphenyl ethers, as well as a variety of marine natural products. (whoi.edu)
  • The AHR controls both adaptive and toxic responses to planar aromatic compounds, including planar HAHs (PHAHs) such as the chlorinated dioxins and some PCBs, as well as polynuclear aromatic hydrocarbons (PAHs). (whoi.edu)
  • This activated heterodimer binds to cognate cis -regulatory sequences (the aryl hydrocarbon receptor response element, AHRE-I) and functions as a transcription factor to recruit coactivators and possibly to interact directly with the basal transcription machinery ( 4 - 6 ). (mcponline.org)
  • The p160 SRC family contains three homologous members, SRC1, SRC2 and SRC3, that interact with nuclear receptors and specific transcription factors. (nature.com)
  • The three homologous members of the p160 SRC family (SRC1, SRC2 and SRC3) mediate the transcriptional functions of nuclear receptors and other transcription factors, and are the most studied of all the transcriptional co-activators. (nature.com)
  • and Stat5, signal transducer and activator of transcription 5) and circadian rhythm (Arntl, aryl hydrocarbon receptor nuclear translocator-like). (medscimonit.com)
  • The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer. (nih.gov)
  • Absolute requirement of aryl hydrocarbon receptor nuclear translocator protein for gene activation by hypoxia. (semanticscholar.org)
  • Antigen standard for aryl hydrocarbon receptor nuclear translocator-like (ARNTL), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
  • AhR nuclear translocator is also a subunit of HYPOXIA-INDUCIBLE FACTOR 1. (uchicago.edu)
  • The aryl hydrocarbon receptor (AhR) is involved in the induction of several enzymes that participate in xenobiotic metabolism. (wikipedia.org)
  • The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. (genecards.org)
  • Among its related pathways are Cytochrome P450 - arranged by substrate type and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) . (genecards.org)
  • The aryl hydrocarbon receptor (AHR) is regarded as an important homeostatic transcriptional regulator within physiological and pathophysiological processes, including xenobiotic metabolism, endocrine function, immunity, and cancer. (aspetjournals.org)
  • DNA reactions, mutagenic action and stealth properties of polycyclic aromatic hydrocarbon carcinogens [review]. (wiley.com)
  • However, IL-12 signaling alone was not sufficient to promote NK cell IL-10, and activation of the aryl hydrocarbon receptor (AHR) was also required for maximal IL-10 production. (jimmunol.org)
  • Once released from presynaptic axonal terminals, DA interacts with at least five receptor subtypes in the central nervous system (CNS), which have been divided into two groups: the D1-like receptors (D1Rs), comprising D1 and D5 receptors, both positively coupled to adenylyl cyclase and cAMP production, and the D2-like receptors (D2Rs), comprising D2, D3, and D4 receptors, whose activation results in inhibition of adenylyl cyclase and suppression of cAMP production. (genome.jp)
  • SRC1 was the first cloned steroid receptor co-activator that interacts with steroid hormone receptors to promote transcriptional activation in a hormone-dependent manner. (nature.com)
  • In the present study, we employed a diet-induced, insulin-resistant hamster model, as well as cell culture studies, to investigate the potential link between activation of hepatic inflammatory nuclear factor-B (NF-B) signaling cascade and the synthesis and secretion of apoB100-containing lipoproteins. (scialert.net)
  • Because CYP1A1 can metabolize DF 203, the aryl hydrocarbon receptor (AhR) may mediate drug action. (aspetjournals.org)
  • Because HIF-1β is also essential for the xenobiotic response (in which it is termed the aryl hydrocarbon receptor nuclear translocator), we also studied c31 cells, which have a different defect in the xenobiotic response and form the HIF-1 complex normally. (pnas.org)
  • 2018. Independent losses of a xenobiotic receptor across teleost evolution. (uib.no)
  • Hahn, M.E. (2002) Aryl hydrocarbon receptors: Diversity and Evolution. (whoi.edu)
  • The ligand-free, cytosolic form of the aryl hydrocarbon receptor is complexed to heat shock protein 90. (wikipedia.org)
  • 2016. Environmental chemicals modulate polar bear (Ursus maritimus) Peroxisome Proliferator-Activated Receptor Gamma (PPARG) and adipogenesis in vitro. (uib.no)
  • The peripheral clocks can also be entrained independently by different factors such as external nutritional, hormonal and chemical cues that in many cases come from ligand modulation of nuclear receptors and kinase activators. (omicsonline.org)
  • Some of the most toxic HAHs cause toxicity by binding to and activating the aryl hydrocarbon receptor (Ah receptor or AHR). (whoi.edu)
  • the pregnane x receptor (PXR) and the constitutive androstane receptor (CAR). (mcponline.org)
  • Aryl Hydrocarbon Receptor Nuclear Translocator" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • Ectopic expression of ss causes coincident ectopic nuclear localization of Tgo, independent of cell type or developmental stage. (biologists.org)
  • This review details the function of the molecular clock in health and disease and how nuclear receptors and posttranslational modifications interact with the clock to regulate its function. (omicsonline.org)
  • AHR degradation was also blocked in Hepa-1 and HepG2 cells when nuclear export was inhibited with leptomycin B . Mutation of a nuclear export signal present in the AHR resulted in its accumulation in the nucleus and reduced levels of degradation following ligand exposure . (musc.edu)
  • In vitro studies revealed that IL-12 stimulation increased NK cell AHR levels, and the AHR and AHR nuclear translocator were required for optimal production of IL-10. (jimmunol.org)
  • 1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)
  • 1993 ) In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition. (biologists.org)