Arthus Reaction
Vasculitis, Leukocytoclastic, Cutaneous
Disorder characterized by a vasculitic syndrome associated with exposure to an antigen such as a drug, infectious agent, or other foreign or endogenous substance. Its pathophysiology includes immune complex deposition and a wide range of skin lesions. Hypersensitivity or allergy is present in some but not all cases.
Immune Complex Diseases
Group of diseases mediated by the deposition of large soluble complexes of antigen and antibody with resultant damage to tissue. Besides SERUM SICKNESS and the ARTHUS REACTION, evidence supports a pathogenic role for immune complexes in many other IMMUNE SYSTEM DISEASES including GLOMERULONEPHRITIS, systemic lupus erythematosus (LUPUS ERYTHEMATOSUS, SYSTEMIC) and POLYARTERITIS NODOSA.
Edema
Receptor, Anaphylatoxin C5a
Passive Cutaneous Anaphylaxis
An evanescent cutaneous reaction occurring when antibody is injected into a local area on the skin and antigen is subsequently injected intravenously along with a dye. The dye makes the rapidly occurring capillary dilatation and increased vascular permeability readily visible by leakage into the reaction site. PCA is a sensitive reaction for detecting very small quantities of antibodies and is also a method for studying the mechanisms of immediate hypersensitivity.
Antigen-Antibody Complex
Cobra Venoms
Complement C5a
The minor fragment formed when C5 convertase cleaves C5 into C5a and COMPLEMENT C5B. C5a is a 74-amino-acid glycopeptide with a carboxy-terminal ARGININE that is crucial for its spasmogenic activity. Of all the complement-derived anaphylatoxins, C5a is the most potent in mediating immediate hypersensitivity (HYPERSENSITIVITY, IMMEDIATE), smooth MUSCLE CONTRACTION; HISTAMINE RELEASE; and migration of LEUKOCYTES to site of INFLAMMATION.
Skin
Complement System Proteins
Serum glycoproteins participating in the host defense mechanism of COMPLEMENT ACTIVATION that creates the COMPLEMENT MEMBRANE ATTACK COMPLEX. Included are glycoproteins in the various pathways of complement activation (CLASSICAL COMPLEMENT PATHWAY; ALTERNATIVE COMPLEMENT PATHWAY; and LECTIN COMPLEMENT PATHWAY).
Receptors, Complement
Receptors, IgG
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
Neutrophil Infiltration
Neutrophils
Hypersensitivity, Delayed
Cutting edge: Fc receptor type I for IgG on macrophages and complement mediate the inflammatory response in immune complex peritonitis. (1/146)
The contributions of Fc receptors (FcRs) for IgG (FcgammaRs) and complement to immune complex (IC)-mediated peritonitis were evaluated in BALB/c-, C57BL/6-, FcRgamma chain-, and FcR type III for IgG (FcgammaRIII)-deficient mice, backcrossed to the C57BL/6 background. In BALB/c mice, but not in C57BL/6 mice, neutrophil migration was markedly attenuated after complement depletion. In mice lacking FcRgamma chain, neutrophil migration was abolished, whereas it was unaffected in FcgammaRIII-deficient mice. Huge amounts of TNF-alpha (TNF) were found in the peritoneal exudate of BALB/c and C57BL/6 mice but were absent in mice lacking FcRgamma chain or FcgammaRIII. Surprisingly, a functional inhibition of TNF in BALB/c and C57BL/6 mice had no effect on neutrophil infiltration. These data provide evidence that in IC peritonitis, the activation of FcR type I for IgG on peritoneal macrophages and the activation of the complement cascade, but not the interaction of ICs with FcgammaRIII and the subsequent release of TNF, initiate the inflammatory response in BALB/c and C57BL/6 mice. (+info)Selection of a C5a receptor antagonist from phage libraries attenuating the inflammatory response in immune complex disease and ischemia/reperfusion injury. (2/146)
A C5a-receptor antagonist was selected from human C5a phage display libraries in which the C terminus of des-Arg74-hC5a was mutated. The selected molecule is a competitive C5a receptor antagonist in vitro and in vivo. Signal transduction is interrupted at the level of G-protein activation. In addition, the antagonist does not cause any C5a receptor phosphorylation. Proinflammatory properties such as chemotaxis or lysosomal enzyme release of differentiated U937 cells, as well as C5a-induced changes in intracellular Ca2+ concentration of murine peritoneal macrophages, are inhibited. The in vivo efficacy was evaluated in three different animal models of immune complex diseases in mice, i.e., the reverse passive Arthus reaction in the peritoneum, skin, and lung. The i.v. application of the C5a receptor antagonist abrogated polymorphonuclear neutrophil accumulation in peritoneum and markedly attenuated polymorphonuclear neutrophil migration into the skin and the lung. In a model of intestinal ischemia/reperfusion injury, i.v. administration of the C5a receptor antagonist decreased local and remote tissue injury: bowel wall edema and hemorrhage as well as pulmonary microvascular dysfunction. These data give evidence that C5a is an important mediator triggering the inflammatory sequelae seen in immune complex diseases and ischemia/reperfusion injury. The selected C5a receptor antagonist may prove useful to attenuate the inflammatory response in these disorders. (+info)IL-1 and TNF receptor-deficient mice show decreased inflammation in an immune complex model of uveitis. (3/146)
PURPOSE: To determine the role of interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) in the induction of uveitis by a reverse passive Arthus reaction (RPAR). METHODS: Human serum albumin (HSA) antiserum was injected into the vitreous of "knockout" or "double knockout" mice genetically deficient in IL-1 receptor type I (IL-1RI-/-), TNF receptors p55 and p75 (TNFR p55-/-/p75-/-), IL-1RI and TNFR p55 (IL-1RI-/-/TNFR p55-/-), and controls. Twenty-four hours later, animals were challenged with intravenous HSA. Eyes were enucleated 4 hours after antigen challenge, and inflammation was quantitated by counting cells on histologic sections. Interleukin-6 in aqueous humor was measured with a B9 cell bioassay. The distribution of immune complexes in eyes was observed by immunohistochemical staining for IgG and complement component C3. RESULTS: Four hours after antigen challenge, immune complexes were localized at the ciliary body and iris of receptor-deficient mice. A transient uveitis was most severe at this time. A significant reduction in the median number of infiltrating cells was found in TNFR p55-/-/p75-/- mice (4.8, n = 15), compared with controls (14.2, n = 20, P < 0.05). The median number of infiltrating cells was significantly reduced in IL-1RI-/- mice (knockout 2.6, n = 11; controls 7.4, n = 8, P < 0.005). Interleukin-1RI-/-/TNFR p55-/- mice had a strong reduction in infiltrating cells (knockout 1.6, n = 11; controls 27.3, n = 12, P = 0.002). Interleukin-6 activity in aqueous humor was reduced in IL-1RI-/-/TNFR p55-/- mice (P = 0.03) but not in TNFR p55-/-/p75-/- (P = 0.40) mice. Most IL-1RI-/-mice had no detectable aqueous humor IL-6, but this group was not statistically different from controls. CONCLUSIONS: In contrast to endotoxin-induced uveitis, both IL-1 and TNF appear to have critical roles in RPAR uveitis. When receptors for these cytokines were deleted, the severity of immune complex-induced uveitis was profoundly reduced. (+info)The Arthus reaction in rodents: species-specific requirement of complement. (4/146)
We induced reverse passive Arthus (RPA) reactions in the skin of rodents and found that the contribution of complement to immune complex-mediated inflammation is species specific. Complement was found to be necessary in rats and guinea pigs but not in C57BL/6J mice. In rats, within 4 h after initiation of an RPA reaction, serum alternative pathway hemolytic titers decreased significantly below basal levels, whereas classical pathway titers were unchanged. Thus the dermal reaction proceeds coincident with systemic activation of complement. The serine protease inhibitor BCX 1470, which blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro, also blocked development of RPA-induced edema in the rat. These data support the proposal that complement-mediated processes are of major importance in the Arthus reaction in rats and guinea pigs, and suggest that BCX 1470 will be useful as an anti-inflammatory agent in diseases where complement activation is known to be detrimental. (+info)A codominant role of Fc gamma RI/III and C5aR in the reverse Arthus reaction. (5/146)
Recent attempts to specify the relative contribution of FcR and complement in various experimental systems of immune complex disease have led to opposing conclusions. As concluded in IgG FcRgamma-/- mice, manifestation of disease is almost exclusively determined by FcgammaR on effector cells, arguing for a minor role of complement. In contrast, data obtained with C5aR-/- mice suggested that, dependent on the tissue site, complement is more important than FcgammaR. In this paper, we demonstrate that, in response to IgG immune complex formation, FcgammaRI/III- and C5aR-mediated pathways are both necessary and only together are they sufficient to trigger the full expression of inflammation in skin and lung. Moreover, both effector systems are not entirely independent, suggesting an interaction between FcgammaR and C5aR. Therefore, FcgammaR-mediated responses can be integrated through C5aR activation, which may explain why these two receptor pathways have previously been considered to dominate each other. (+info)Contribution of B(2) receptors for bradykinin in arthus reaction-induced plasma extravasation in wild-type or B(2) transgenic knockout mice. (6/146)
The aim of the present study was to investigate the contribution of bradykinin (BK) B(1) and B(2) receptors in a model of type III hypersensitivity, the reverse passive Arthus reaction (RPA), in wild-type mice and transgenic B(2) knockout littermates. BK (10 microg mouse(-1)) or bovine serum albumin (0.5 mg mouse(-1)) induced a sustained Evans blue extravasation for more than 80 min in naive or rabbit anti-bovine serum albumin-treated mice (RPA model), respectively. The response to the two stimuli was prevented by the B(2) receptor antagonist, HOE-140, but not by [Leu(8)]desArg(9)-BK (B(1) receptor antagonist). In contrast to the wild-type littermates, RPA and bradykinin were unable to trigger an increase in plasma extravasation in B(2) knockout mice. Furthermore, endothelin-1 (5 microg mouse(-1)) and a selective NK-1 receptor agonist [Sar(9),Met (O(2))(11)]-SP (20 microg mouse(-1)), triggered a significant increase in peritoneal plasma extravasation in both wild-type and B(2) knockout animals. A pretreatment with indomethacin (200 microg mouse(-1)) significantly reduced the RPA-induced but not the BK-induced increase in Evans blue extravasation. Furthermore, RPA, but not BK, triggered a significant indomethacin-sensitive increase in peritoneal prostaglandin E(2) content. Our results suggest a pivotal role for B(2) receptors in the mechanism of plasma extravasation which occurs during the reverse passive Arthus reaction in the mouse. Moreover, our results suggest an important contribution of prostanoids in the plasma leakage mechanisms triggered by RPA but not by bradykinin. (+info)A new small molecule C5a receptor antagonist inhibits the reverse-passive Arthus reaction and endotoxic shock in rats. (7/146)
C5a is implicated as a pathogenic factor in a wide range of immunoinflammatory diseases, including sepsis and immune complex disease. Agents that antagonize the effects of C5a could be useful in these diseases. We have developed some novel C5a antagonists and have determined the acute anti-inflammatory properties of a new small molecule C5a receptor antagonist against C5a- and LPS-induced neutrophil adhesion and cytokine expression, as well as against some hallmarks of the reverse Arthus reaction in rats. We found that a single i.v. dose (1 mg/kg) of this antagonist inhibited both C5a- and LPS-induced neutropenia and elevated levels of circulating TNF-alpha, as well as polymorphonuclear leukocyte migration, increased TNF-alpha levels and vascular leakage at the site of immune complex deposition. These results indicate potent anti-inflammatory activities of a new C5a receptor antagonist and provide more evidence for a key early role for C5a in sepsis and the reverse Arthus reaction. The results support a role for antagonists of C5a receptors in the therapeutic intervention of immunoinflammatory disease states such as sepsis and immune complex disease. (+info)Lyn is essential for fcgamma receptor III-mediated systemic anaphylaxis but not for the Arthus reaction. (8/146)
The Src family kinase Lyn initiates intracellular signal transduction by associating with a variety of immune receptors such as antigen receptor on B cells and high-affinity Fc receptor (FcR) for immunoglobulin Ig(E) (FcepsilonRI) on mast cells. Involvement of Lyn in the IgE-mediated immediate-type hypersensitivity is well documented, but the physiological significance of Lyn in IgG-dependent, type III low-affinity FcR for IgG (FcgammaRIII)-mediated responses is largely unknown. In this study, we generated a double-mutant mouse strain deficient in both type II FcR for IgG (FcgammaRIIB) and Lyn to exclude any involvement of inhibitory signaling by FcgammaRIIB, which otherwise downregulates FcgammaRIII-mediated cellular responses. FcgammaRIIB-deficient but Lyn-sufficient mice served as controls. The Lyn deficiency attenuated IgG-mediated systemic anaphylaxis in vivo, and significantly reduced calcium mobilization and degranulation responses of bone marrow-derived mast cells (BMMCs) in vitro. However, we found that either interleukin 4 or tumor necrosis factor alpha release by BMMCs was comparable to that from Lyn-deficient and control mice, and the reverse-passive Arthus reaction was equally induced in both mutant mice, indicating that Lyn is not involved in the onset of the IgG-mediated, FcgammaRIII-dependent late phase responses of mast cells. These findings provide us with insight into distinct signaling mechanisms in mast cells underlying the development of diverse pathologies as well as a therapeutic potential for selective treatment of allergic disorders. (+info)Effects of dapsone on passive Arthus reaction and chemotaxis and phagocytosis of polymorphonuclear leukocytes<...
PMN infiltration in the reverse Arthus reaction in the | Open-i
C5a-dependent secretion of IL-6. The reverse passive Ar | Open-i
The Impact of Fc Receptors on the Development of Autoimmune Diseases | Bentham Science
A Codominant Role of FcγRI/III and C5aR in the Reverse Arthus Reaction | The Journal of Immunology
THE MECHANISM OF ACTION OF 17-HYDROXY-11-DEHYDROCORTICOSTERONE (COMPOUND E) AND OF THE ADRENOCORTICOTROPIC HORMONE IN...
Immune complex-mediated hypersensitivity reaction | Article about immune complex-mediated hypersensitivity reaction by The Free...
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Arthus reaction
The Arthus reaction was discovered by Nicolas Maurice Arthus in 1903. Arthus repeatedly injected horse serum subcutaneously ... the Arthus reaction (/ˌɑːrˈtjuːs/) is a type of local type III hypersensitivity reaction. Type III hypersensitivity reactions ... The CDC's description: Arthus reactions (type III hypersensitivity reactions) are rarely reported after vaccination and can ... an Arthus reaction occurs. Typical of most mechanisms of the type III hypersensitivity, Arthus manifests as local vasculitis ...
Nicolas Maurice Arthus
The Arthus reaction, a localized inflammatory response, is named after him. Arthus was born on 9 January 1862 in Angers, France ... Apart from the reaction named after him, Arthus is best known for his work on anaphylaxis. He also studied snake venom and the ... Nicolas Maurice Arthus, in World Who's Who in Science, Allen G. Debus et al., ed., Chicago: Marquis-Who's Who, Inc., 1968. ... P. Nolf, N. M. Arthus, et al.: Hommage à Léon Fredericq, professeur de physiologie à l'Université de Liége. Liége, 1938. 79 ...
Serum sickness
Hypersensitivity Arthus reaction Serum sickness-like reaction Brucculeri M, Charlton M, Serur D (2006). "Serum sickness-like ... They can also cause more reactions, causing the typical symptoms of serum sickness. This is similar to a generalised Arthus ... Skin testing may be used beforehand in order to identify individuals who may be at risk of a reaction. Physicians should make ... The choice depends on the severity of the reaction. Prednisone may be used in severe cases. Use of plasmapheresis has also been ...
T helper 17 cell
Rheumatoid arthritis or Arthus reaction belong to this category. Apart from autoantigen reactivity, Th17 cells inherent biology ...
Type III hypersensitivity
Skin response to hypersensitivity of this type is referred to as an Arthus reaction and is characterized by local erythema and ... "Type III Hypersensitivity Reaction". The Lecturio Medical Concept Library. Retrieved 22 July 2021. "Hypersensitivity reactions ... Such reactions may progress to immune complex diseases. Some clinical examples: Other examples are: Subacute bacterial ... The relevance of the Gell and Coombs classification of allergic reactions is questioned in the modern-day understanding of ...
Arthus
... may refer to: Arthus reaction, a type of local type III hypersensitivity reaction Arthus-Bertrand, a French maker of ... medals and decorations Tangara arthus or Golden tanager, a species of bird in the family Thraupidae Le roi Arthus (King Arthur ... This disambiguation page lists articles associated with the title Arthus. If an internal link led you here, you may wish to ...
Booster dose
If a patient receives a booster dose but already has a high level of antibody, then a reaction called an Arthus reaction could ... and could cause fever and local reactions in people who received the vaccine. In the 1990s, people in the US started using ... "Immunologic Reactions". National Academies Press (US). {{cite journal}}: Cite journal requires ,journal= (help) University of ...
List of MeSH codes (C20)
... arthus reaction MeSH C20.543.520.770 - serum sickness MeSH C20.543.520.910 - vasculitis, hypersensitivity MeSH C20.543.520.910. ...
Timeline of immunology
"Arthus reaction" (Maurice Arthus) 1903 - Opsonization 1905 - "Serum sickness" allergy (Clemens von Pirquet and (Bela Schick) ... Cutaneous allergic reactions (Otto Prausnitz and Heinz Küstner) 1924 - Reticuloendothelial system 1938 - Antigen-Antibody ...
List of eponymous diseases
Hans Chiari Arthus reaction - Nicolas Maurice Arthus Asherman syndrome - Joseph G. Asherman Asperger syndrome (a.k.a. Asperger ... Georges Andre Hauser Mazzotti reaction - Luigi Mazzotti McArdle's Disease - Brian McArdle McCune-Albright syndrome - Donovan ...
Outline of immunology
... vasculitis Reactive arthritis Farmer's lung Post-streptococcal glomerulonephritis Serum sickness Arthus reaction Autoimmune ...
Mosquito bite allergy
The latter reactions, which appear to be caused by the development of an inflammatory Arthus reaction at the site, may be very ... The full delayed reaction is a type IV hypersensitivity reaction. The diagnosis of ordinary mosquito reactions is made on the ... Individuals also vary in the severity of their reactions to mosquito bites. Most individuals show a "small reaction" in which a ... This part of the immediate reaction is a classical type I hypersensitivity reaction. The acquired IgG binds mosquito saliva ...
List of ICD-9 codes 800-999: injury and poisoning
995.55 Shaken infant syndrome 995.6 Anaphylactic shock due to adverse food reaction 995.60 Anaphylactic shock due to ... 995.20 Unspecified adverse effect of unspecified drug, medicinal and biological substance 995.21 Arthus phenomenon 995.22 ... 995.68 Anaphylactic shock due to eggs 995.69 Anaphylactic shock due to other specified food 995.7 Other adverse food reactions ... classified 999.1 Air embolism as a complication of medical care not elsewhere classified 999.8 Other transfusion reaction not ...
Pelléas et Mélisande (opera)
Messager described the reaction: "[It was] certainly not a triumph, but no longer the disaster of two days before...From the ... Le roi Arthus). Debussy was far from impressed by the results: "We are bound to admit that nothing was ever more dreary than ... She described Debussy's reaction on learning her nationality: "Une autre anglaise-Mon Dieu" (Another Englishwoman-my God). ... Critical reaction was mixed. Some accused the music of being "sickly and practically lifeless" and of sounding "like the noise ...
Spamalot
The production featured Yūsuke Santamaria as King Arthus, Aya Hirano as Lady of the Lake, Magy as Patsy, Yuya Matsushita as Sir ... In Slate, Sam Anderson wrote, "Python was formed in reaction to exactly the kind of lazy comedy represented by Spamalot - what ... Who gave them a million dollars each for 'Spamalot'? - Eric Idle The show has had mixed reactions from Idle's former colleagues ... Michael Palin once described as the 'easy, catch-phrase reaction' the members had all been forced to pander in their previous ...
Red-bellied black snake
Severe local reactions may require surgical debridement or even amputation. Symptoms of systemic envenomation-including nausea ... 1. Paris: Arthus Bertrand. Archived from the original on 24 October 2017. Retrieved 21 February 2018. Schlegel, Hermann (1837 ...
Christophe Beauregard
Focusing on the cultural trend of body art and tattoos, it is interesting to see the reverse reaction. Acknowledging the fact ... Laure Adler, Akhenaton, Mathieu Amalric, John Armleder, Yann Arthus-Bertrand, Georg Baselitz, Booba, Pascal Bruckner, John Cale ...
Royal Canadian Air Force Exercise Plans
Gerard Arthus. Gerard Arthus. Royal Canadian Air Force (1962). Royal Canadian Air Force Exercise Plans for Physical Fitness. ... This concept drew a negative reaction from others in the field at the time but it proved its worth in the three years of ...
Fernand Khnopff
The vehement reaction of "La Caron" on this occasion made a scandal in the Belgian and Parisian press and would help to ... Khnopff had been engaged to design the costumes and the sets for the World premiere of Ernest Chausson's opera Le Roi Arthus at ...
Colombia magia salvaje
And then, a reaction". The creator of the film's original music is David Campbell, a composer with a career in soundtracks from ... He learned firsthand the work of cinematographer Yann Arthus-Bertrand, specializing in animal images and aerial photography. ... achieve a reaction in them and in the end an attitude of protection against nature: "when you have an audience in love, and see ...
Troubadour style
It can be seen as an aspect of Romanticism and a reaction against Neoclassicism, which was coming to an end at the end of the ... Arthus de Bretagne, Fleurs de batailles, Dom Ursino de Navarin et Dona Inès d'Ovidéo, Gérard de Nevers, etc.. Its accompanying ... 1822 Reaction to this genre, as to the Pre-Raphaelites in England, has been mixed. It can be seen as overly sentimental or ...
Coronation of Bokassa I
The imperial crown was made by Arthus Bertrand, a jeweler from Saint-Germain-des-Prés. The design of the crown was traditional ... The coronation of Bokassa I provoked a mixed reaction throughout the world, and led to mainly negative comments in Africa. ... The reaction in Europe was generally dismissive: French journalists associated the coronation with a masquerade, ridiculing the ...
Coagulation
Arthus M, Pagès C (1890). "Nouvelle theorie chimique de la coagulation du sang". Arch Physiol Norm Pathol. 5: 739-46. Shapiro ... The pathways are a series of reactions, in which a zymogen (inactive enzyme precursor) of a serine protease and its ... Arthus discovered in 1890 that calcium was essential in coagulation. Platelets were identified in 1865, and their function was ... which both lead to the same fundamental reactions that produce fibrin. It was previously thought that the two pathways of ...
Ursari
... the reaction of local authorities was more calm, and allowed Ursari to blend into Dutch society, even though most members of ... Arthus Betrand, Paris, 1840, p.242-243 (in Romanian) Eugen Şendrea, "Distracţii de tîrgoveţi", in Ziarul de Bacău, May 26, 2007 ...
Millennium Park
Public reaction was negative, as bloggers and the artistic community decried the cameras as inappropriate and a blight on the ... Exelon Presents Earth From Above by Yann Arthus-Bertrand, a French aerial photographer. The Park Grill Plaza is affiliated with ... The Chicago Tribune published an article on the cameras and the public reaction; the cameras were removed the next day, with ...
State defense force
U.S. Army War College Paper "State Defense Forces and Homeland Security"; Arthus Tulak, Robert Kraft, and Don Silbaugh, 2004. ... DECON/CBRN-e Quick Reaction Teams (QRT) (now disbanded) - Small units attached to a number of Texas State Guard Civil Affairs ( ...
Demographic history of Macedonia
Paris: Arthus Bertrand. Brailsford, Henry Noel. (1906). Macedonia: Its Races and Their Future. London: Methuen & Co Carnegie ... decades of official silence created a reaction in the form of numerous data manipulations for nationalist communist propaganda ...
Anggun
... , with this album, had made her music travel to Russia with positive reactions there. In Russia, Elevation was released ... In March 2019, Anggun alongside Yann Arthus-Bertrand, Paul Lynch, Zaz, Kate Atkinson, Joanna Trollope, and more than 450 ...
Arthus Reaction | Pathway Medicine
A New Small Molecule C5a Receptor Antagonist Inhibits the Reverse-Passive Arthus Reaction and Endotoxic Shock in Rats1 | The...
... and formation of the membrane attack complex in a dermal Arthus reaction (24). The Arthus reaction can also be limited by cobra ... which returned to pretreatment values within 4 h of the Arthus reaction induction (Fig. 4). The peritoneal Arthus reaction also ... before initiation of a peritoneal Arthus reaction. The peritoneal cavity was lavaged 4 h after Arthus reaction induction, and ... before initiation of a peritoneal Arthus reaction. The peritoneal cavity was lavaged 4 h after Arthus reaction induction, and ...
THE ARTHUS - SHWARTZMAN REACTION COMPLICATED WITH AN EXTENSIVE NECROTIC PHLEGMON IN A NEWBORN WITH DIODENAL COMPRESSION -...
SHWARTZMAN REACTION COMPLICATED WITH AN EXTENSIVE NECROTIC PHLEGMON IN A NEWBORN WITH DIODENAL COMPRESSION ... THE ARTHUS - SHWARTZMAN REACTION COMPLICATED WITH AN EXTENSIVE NECROTIC PHLEGMON IN A NEWBORN WITH DIODENAL COMPRESSION. ... Occurrence of the Arthus and Shwartzman reaction leading to an extensive necrotizing phlegmon of the body after constant ... Home , Archives , Vol 8, No 4 (2018) , THE ARTHUS - SHWARTZMAN REACTION COMPLICATED WITH AN EXTENSIVE NECROTIC PHLEGMON IN A ...
Update on Immunization - Recommendations of the ACIP
Arthus-type hypersensitivity reactions, characterized by severe local reactions starting 2-8 hours after an injection and often ... immediate hypersensitivity reaction following a pre- vious dose. History of severe local (Arthus- type) reaction following ... The local reaction may be accompanied by fever, malaise, and headache. Serious reactions, including neurologic reactions, after ... Persons experiencing severe Arthus-type hypersensitivity reactions to a dose of T usually have very high serum tetanus ...
நீரிழிவு நோய் - தமிழ் விக்கிப்பீடியா
Adult Immunization Schedule by Vaccine and Age Group | CDC
History of Arthus-type hypersensitivity reactions after a previous dose of diphtheria-toxoid- containing or tetanus-toxoid- ... Severe allergic reaction (e.g., anaphylaxis) to a vaccine component or a previous dose of any influenza vaccine: see Appendix ... Severe allergic reaction (e.g., anaphylaxis) after previous dose of any influenza vaccine (i.e., any egg-based IIV, ccIIV, RIV ... Severe allergic reaction (e.g., anaphylaxis) after previous dose of any influenza vaccine (i.e., any egg-based IIV, ccIIV, RIV ...
Dengue vascular leakage is augmented by mast cell degranulation mediated by immunoglobulin Fcγ receptors | eLife
1996) Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice Immunity 5:181-188. ... 1996) A dominant role for mast cell Fc receptors in the Arthus reaction Immunity 5:387-390. ... have an impaired Arthus reaction, and are resistant to IgG-dependent passive anaphylaxis (Hazenbos et al., 1996). Based on our ... such as the Arthus reaction and anaphylaxis (Vaz and Ovary, 1968; Hazenbos et al., 1996; Sylvestre and Ravetch, 1996). ...
Immunoglobulin G-mediated inflammatory responses develop normally in complement-deficient mice
Using the reverse passive Arthus reaction and experimental models of immune hemolytic anemia and immune thrombocytopenia, we ... Using the reverse passive Arthus reaction and experimental models of immune hemolytic anemia and immune thrombocytopenia, we ... Furthermore, in the reverse passive Arthus reaction, soluble immune complexes induce equivalent levels of hemmorhage, edema, ... In contrast, mice that are genetically deficient in the expression of Fc receptors exhibit grossly diminished reactions by both ...
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It is suggested that PNT begins as an Arthus reaction, followed by a delayed hypersensitivity response, which ... Cutaneous Mycobacterium kansasi infection associated with a papulonecrotic tuberculide reaction. J Am Acad Dermatol 1997;36:497 ... a case of PNT as a reaction to M. kansasii was recently reported.[3] PNT is most commonly seen in adults, with a female ...
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Persons who experienced an Arthus-type hypersensitivity reaction following a prior dose of tetanus toxoid-containing vaccine ... Common solicited adverse reactions (≥15%) in adults (aged 19 to 64 years) were pain, redness and swelling at the injection site ... Common solicited adverse reactions (≥15%) in adolescents (aged 10 to 18 years) were pain, redness and swelling at the injection ... The most common solicited adverse reaction (≥15%) in the elderly (aged 65 years and older) was pain at the injection site. ...
Code System Concept
DeCS
Arthus Reaction - Preferred Concept UI. M0001761. Scope note. A dermal inflammatory reaction produced under conditions of ... fenómeno de Arthus Scope note:. Reacción inflamatoria dérmica producida bajo condiciones de exceso de anticuerpos, cuando en ... note category; an inflamm skin reaction to antibody excess. Allowable Qualifiers:. BL blood. CF cerebrospinal fluid. CI ... A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces ...
Tetanus toxoid adsorbed or fluid dosing, indications, interactions, adverse effects, and more
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Type III hypersensitivity reactions (Arthus reactions), which are characterized by immune complex deposition in blood vessels, ... Type III hypersensitivity reactions (Arthus reactions), which are characterized by immune complex deposition in blood vessels, ... These reactions are characterized. by severe pain, swelling, and sometimes necrosis at the injection site and occur between 4 ... These reactions are characterized. by severe pain, swelling, and sometimes necrosis at the injection site and occur between 4 ...
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Pesquisa | Biblioteca Virtual em Saúde - BRASIL
... no Arthus cases were reported. We conclude that Arthus reaction following Tdap is extremely rare. Increasing frequency of ... Rates of injection site reactions, solicited systemic reactions, and unsolicited adverse events, adverse reactions, and serious ... We aimed to describe trends in spontaneously reported Arthus reactions following Tdap in the US and to assess the risk of this ... We found 192 Arthus reports in VAERS after any vaccine, of which 36 occurred after Tdap and none were reported during pregnancy ...
MCQs of General Pathology - Inflammation, Immunity And Hypersensitivity - Multiple Choice Question | Multiple Choice Question
Boostrix Side Effects, Uses & Warnings | ClusterMed.info
Arthus-Type Hypersensitivity Persons who experienced an Arthus-type hypersensitivity reaction following a prior dose of a ... Immune System Disorders: Allergic reactions, including anaphylactic and anaphylactoid reactions. Cardiac Disorders: Myocarditis ... Solicited local adverse reactions and general adverse events were recorded on diary cards for 4 days (day 0-3) following each ... Solicited Adverse Events in the US Adult (19 to 64 Years of Age) Study Table 3 presents solicited local adverse reactions and ...
Papulonecrotic Tuberculids: Background, Pathophysiology, Etiology
From Arthus reaction to lupus vulgaris. Br J Dermatol. 1974 Sep. 91(3):263-70. [QxMD MEDLINE Link]. ... Most authors believe this disease entity is triggered by an initial Arthus reaction to mycobacterial antigens. This is then ... Over time, this type III hypersensitivity reaction may be replaced by a type IV reaction. Other authors dispute this mechanism ... Polymerase chain reaction (PCR) amplification for mycobacteria varies. In a series of 12 cases in India, PCR positivity was ...
Dragon Exploration System for Marine Sponge Compounds Interactions
Platelets, Arthus-type reactions and inflammatory mediators.. 1379617 Nitric oxide production in host-versus-graft and graft- ... Platelets, Arthus-type reactions and inflammatory mediators.. 12518800 Cytotoxicity evaluation of gelatin sponges prepared with ... versus-host reactions in the rat.. 16207631 Murine chemokine CXCL2/KC is a surrogate marker for angiogenic activity in the ...
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TAMATINIB
Diphtheria Pertussis And Tetanus Vaccine || Central Research Institute
History of Arthus-type hypersensitivity reactions after a previous dose of tetanus or diphtheria toxoid-containing vaccine; ... ADVERSE REACTIONS (IF ANY) *MILD PROBLEMS (Common): Fever; Redness or swelling; Soreness or tenderness at the site of injection ... Allergic reactions with component of product should be borne in mind. *Separate sterile syringe should be used for each ... Severe allergic reaction (e.g., anaphylaxis) after a previous dose or to a vaccine component ...
Hypersensitivity reaction8
- These immune complexes rapidly precipitate at the site of injection and cause a purely localized Type III Hypersensitivity reaction. (pathwaymedicine.org)
- Persons who experienced an Arthus-type hypersensitivity reaction following a prior dose of tetanus toxoid-containing vaccine should not receive BOOSTRIX unless 10 years have elapsed since the last dose of a tetanus toxoid-containing vaccine. (gsk.com)
- The eruption is believed to represent a hypersensitivity reaction to tuberculosis antigens released from a distant focus of infection. (medscape.com)
- This is then followed by a hypersensitivity reaction in which antigens undergo opsonization by antibodies, followed by immune complex deposition in small cutaneous blood vessels. (medscape.com)
- Over time, this type III hypersensitivity reaction may be replaced by a type IV reaction. (medscape.com)
- A consensus has been reached that papulonecrotic tuberculid represents a true hypersensitivity reaction rather than the result of a local cutaneous tuberculosis infection. (medscape.com)
- Immunoglobulin involved in type I hypersensitivity reaction is IgE. (medicosplexus.com)
- Arthus reaction is localized immune complex type of hypersensitivity reaction. (medicosplexus.com)
Reverse passive3
- Using the reverse passive Arthus reaction and experimental models of immune hemolytic anemia and immune thrombocytopenia, we show that these mice have types II and III inflammatory responses that are indistinguishable from those of wild-type animals. (nih.gov)
- Furthermore, in the reverse passive Arthus reaction, soluble immune complexes induce equivalent levels of hemmorhage, edema, and neutrophillic infiltration in complement-deficient and wild-type animals. (nih.gov)
- Consistent with Syk inhibition, oral administration of R406 to mice reduced immune complex-mediated inflammation in a reverse-passive Arthus reaction and two antibody-induced arthritis models. (ncats.io)
Antigens2
- In the Arthus Reaction, exogenous antigens are delivered locally by subcutaneous injection and are rapidly bound by circulating antibody , generating immune complexes. (pathwaymedicine.org)
- Most authors believe this disease entity is triggered by an initial Arthus reaction to mycobacterial antigens. (medscape.com)
Severe4
- [12] Food, insect stings , and medications are common causes of severe reactions. (mdwiki.org)
- [15] In severe reactions injectable adrenaline (epinephrine) is recommended. (mdwiki.org)
- Rabbits immunized to a classical soluble antigen, human serum albumin, to the point where severe Arthus skin reactivity was demonstrable, were aerosol challenged with antigen. (cdc.gov)
- In rare cases, severe systemic allergic reactions are possible. (gaugmentin.store)
Mast Cells1
- 20 , 22 , 23 The situation for IgE was less confounding, and the identification and characterization of a high-affinity receptor for this isotype on mast cells offered a plausible explanation for many of the inflammatory features of allergic reactions, 24 validated later by mouse knockouts of this receptor. (oncohemakey.com)
Anaphylaxis2
- The nature of anaphylaxis is such that the reaction can seem to be subsiding, but may recur throughout a period of time. (mdwiki.org)
- With the development of systemic reactions (urticaria, Quincke's edema, anaphylaxis), it is necessary to provide emergency care with the introduction of adrenaline, glucocorticosteroids, antihistamines, maintaining the function of blood circulation and respiration. (gaugmentin.store)
Necrosis2
- Reacción inflamatoria dérmica producida bajo condiciones de exceso de anticuerpos, cuando en una segunda inyección de antígenos se producen complejos antígeno-anticuerpo intravasculares que se unen al complemento, provocando agregación celular, daño endotelial y necrosis vascular. (bvsalud.org)
- A dermal inflammatory reaction produced under conditions of antibody excess, when a second injection of antigen produces intravascular antigen-antibody complexes which bind complement, causing cell clumping, endothelial damage, and vascular necrosis. (bvsalud.org)
Allergic reaction2
- Appropriate medical treatment to manage allergic reactions must be immediately available in the event an acute allergic reaction occurs following administration of BOOSTRIX. (gsk.com)
- In rare cases, people may also experience an allergic reaction to the medication. (etsypk.com)
PHENOMENON1
- In rare cases, prolonged administration of insulin preparations to the same area of the body can lead to the development of local allergic complications such as the Arthus phenomenon. (gaugmentin.store)
Antibodies1
- In contrast, mice that are genetically deficient in the expression of Fc receptors exhibit grossly diminished reactions by both cytotoxic antibodies and soluble immune complexes. (nih.gov)
Complement2
- Immunological complexes activate the complement system's variety of immune effector molecules, resulting in Type III hypersensitivity reactions. (microbiologynote.com)
- 21 Studies on IC-mediated inflammatory responses in these animals, such as the Arthus reaction, led to the realization that IgG FcRs and not the classical pathway of complement activation were the functional mediators of inflammatory responses triggered by ICs. (oncohemakey.com)
Polymerase2
- Although the organisms are absent, mycobacterial DNA has been detected in approximately half of the biopsy specimens subjected to polymerase chain reaction (PCR). (medscape.com)
- Polymerase chain reaction (PCR) amplification for mycobacteria varies. (medscape.com)
Acute2
- We have developed some novel C5a antagonists and have determined the acute anti-inflammatory properties of a new small molecule C5a receptor antagonist against C5a- and LPS-induced neutrophil adhesion and cytokine expression, as well as against some hallmarks of the reverse Arthus reaction in rats. (aai.org)
- Acute adverse events (fever, allergy, and local reactions) and adverse birth outcomes (small for gestational age, preterm delivery, and low birth weight) were evaluated. (cdc.gov)
Fever1
- [8] Allergen immunotherapy , which gradually exposes people to larger and larger amounts of allergen, is useful for some types of allergies such as hay fever and reactions to insect bites. (mdwiki.org)
DISEASES2
- 8 , 9 This common structure suggested a functional link between IC diseases and allergic reactions, a prediction that was confirmed through mouse knockout studies of IgG FcRs. (oncohemakey.com)
- Allergy to insulin must be differentiated from other allergic diseases, pseudo-allergic reactions, viral infections, skin diseases, pruritus in renal failure and lymphoproliferative diseases, neoplasms. (gaugmentin.store)
Vaccine1
- Many factors have influenced the use of vaccines among adults, including lack of awareness of safe vaccines and vaccine- preventable health burdens, unfounded concerns about adverse reactions, and missed opportunities by health-care providers to vaccinate adults during office, clinic, or hospital visits. (cdc.gov)
Injection site2
- The most common solicited adverse reaction (≥15%) in the elderly (aged 65 years and older) was pain at the injection site. (gsk.com)
- Allergy to insulin with the development of systemic, generalized reactions occurs in 0.2% of patients with diabetes mellitus, while more often clinical symptoms are limited to the appearance of urticaria (hyperemia, itchy blisters at the injection site), even less often - the development of augmentin pills or anaphylactic shock. (gaugmentin.store)
Respiratory1
- Food allergies rarely cause respiratory (asthmatic) reactions, or rhinitis . (mdwiki.org)
Local1
- The Arthus Reacion is a specialized, local subtype of Type III Hypersensitivity . (pathwaymedicine.org)
Receptor2
- These results indicate potent anti-inflammatory activities of a new C5a receptor antagonist and provide more evidence for a key early role for C5a in sepsis and the reverse Arthus reaction. (aai.org)
- The interaction between ADH and the vasopressin V2 receptor triggers chemical reactions that control the body's water balance. (medlineplus.gov)
Type6
- Platelets, Arthus-type reactions and inflammatory mediators. (edu.sa)
- Large levels of immune complexes can cause tissue-damaging type III hypersensitivity reactions in certain instances. (microbiologynote.com)
- The release of lytic enzymes by neutrophils attempting to phagocytose immune complexes contributes significantly to tissue damage in type III reactions. (microbiologynote.com)
- The same processes mediating type II HS reactions against fixed tissues then result in cellular damage. (microbiologynote.com)
- This type of reaction can be triggered suddenly, or the onset can be delayed. (mdwiki.org)
- If insulin therapy has been discontinued for 2-3 days or more, it is necessary to check the sensitivity to a particular drug by conducting skin tests and determining the type of insulin that causes the least allergic reactions. (gaugmentin.store)
Skin1
- With an intradermal test, an insulin solution is injected at a dose of 0.02 ml (dilution 0.004 units / ml), the skin reaction is assessed after an hour according to the severity of augmentin and the size of the papule that has appeared. (gaugmentin.store)
Tissue1
- A localised reaction develops when the complexes are deposited in tissue very close to the site of antigen entrance. (microbiologynote.com)
Human1
- We identified the human DHCR24 cDNA, by the similarity between the encoded protein and a recently characterized plant enzyme-DWF1/DIM, from Arabidopsis thaliana -catalyzing a different but partially similar reaction in steroid/sterol biosynthesis in plants. (cell.com)
Result1
- Aside from these ambient allergens, allergic reactions can result from foods , insect stings , and reactions to medications like aspirin and antibiotics such as penicillin . (mdwiki.org)
Years1
- This has provoked numerous reactions: over the past 15 years, a sometimes enchanted imagery of the city's edges has developed. (metropolitics.org)
Correct2
- Occurrence of the Arthus and Shwartzman reaction leading to an extensive necrotizing phlegmon of the body after constant intravenous infusions of protein preparations used to correct metabolic disturbances in a newborn with partial congenital duodenal compression. (rps-journal.ru)
- Prevention consists in the correct selection of insulin preparations and their timely replacement in case of allergic reactions. (gaugmentin.store)
Specific2
- and specific side effects, adverse reactions, precautions, and contraindi- cations associated with use of these immunobiologics. (cdc.gov)
- Standard clinical studies are carried out to assess the general condition of the body and the level of diabetes compensation, the level of general and specific immunoglobulins is determined, as well as other studies used in practical allergology to exclude allergic reactions of another etiology. (gaugmentin.store)
Place1
- 2. Place 1 drop of this mixture on a new reaction circle. (genomeboy.com)