Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.ArthritisArthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Arthritis, Infectious: Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.Arthritis, Juvenile: Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.Arthritis, Psoriatic: A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.Arthritis, Reactive: An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.Synovial Membrane: The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.Joints: Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.Synovial Fluid: The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.Arthritis, Gouty: Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.Mice, Inbred DBASynovitis: Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Rats, Inbred LewAutoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Blood Sedimentation: Measurement of rate of settling of erythrocytes in anticoagulated blood.Injections, Intra-Articular: Methods of delivering drugs into a joint space.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Arthrography: Roentgenography of a joint, usually after injection of either positive or negative contrast medium.Rheumatology: A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Metacarpophalangeal Joint: The articulation between a metacarpal bone and a phalanx.Spondylitis, Ankylosing: A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Gold Sodium Thiomalate: A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.Wrist Joint: The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).Rheumatoid Nodule: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).HLA-DRB1 Chains: A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.Finger Joint: The articulation between the head of one phalanx and the base of the one distal to it, in each finger.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Tarsal Joints: The articulations between the various TARSAL BONES. This does not include the ANKLE JOINT which consists of the articulations between the TIBIA; FIBULA; and TALUS.Lyme Disease: An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.HLA-DR4 Antigen: An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Joint DiseasesHLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.CitrullineCytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Spondylarthropathies: Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.Foot Joints: The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Ankle Joint: The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Interleukin-17: A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Freund's Adjuvant: An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.Tarsus, Animal: The region in the hindlimb of a quadruped, corresponding to the human ANKLE.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Tenosynovitis: Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.HLA-B27 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Organogold Compounds: Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Hand Joints: The articulations extending from the WRIST distally to the FINGERS. These include the WRIST JOINT; CARPAL JOINTS; METACARPOPHALANGEAL JOINT; and FINGER JOINT.Glucose-6-Phosphate Isomerase: An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.Disability Evaluation: Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Interleukin-6: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Interleukin-1: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Interleukin 1 Receptor Antagonist Protein: A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It supports research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress. It was established in 1986.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Mice, Inbred C57BLCase-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.Borrelia burgdorferi: A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Hindlimb: Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)Yersinia Infections: Infections with bacteria of the genus YERSINIA.Arthralgia: Pain in the joint.Spondylarthritis: Inflammation of the joints of the SPINE, the intervertebral articulations.Autoimmunity: Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Toe Joint: The articulation between the head of one phalanx and the base of the one distal to it, in each toe.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Hand Deformities, Acquired: Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Bone Resorption: Bone loss due to osteoclastic activity.Matrix Metalloproteinase 3: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)Interleukin-1beta: An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Felty Syndrome: A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Hand: The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Sternoclavicular Joint: A double gliding joint formed by the CLAVICLE, superior and lateral parts of the manubrium sterni at the clavicular notch, and the cartilage of the first rib.Inflammation Mediators: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).Metatarsophalangeal Joint: The articulation between a metatarsal bone (METATARSAL BONES) and a phalanx.Auranofin: An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Protein Tyrosine Phosphatase, Non-Receptor Type 22: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.Gout: Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Spondylitis: Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.Osteitis: Inflammation of the bone.Mice, Inbred BALB CArthritis-Encephalitis Virus, Caprine: A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), closely related to VISNA-MAEDI VIRUS and causing acute encephalomyelitis; chronic arthritis; PNEUMONIA; MASTITIS; and GLOMERULONEPHRITIS in goats. It is transmitted mainly in the colostrum and milk.Biological Therapy: Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Health Status: The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.Epitopes: Sites on an antigen that interact with specific antibodies.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Early Diagnosis: Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Th17 Cells: Subset of helper-effector T-lymphocytes which synthesize and secrete IL-17, IL-17F, and IL-22. These cytokines are involved in host defenses and tissue inflammation in autoimmune diseases.Activities of Daily Living: The performance of the basic activities of self care, such as dressing, ambulation, or eating.Aurothioglucose: A thioglucose derivative used as an antirheumatic and experimentally to produce obesity in animals.Bone Diseases: Diseases of BONES.Disease Susceptibility: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.Borrelia burgdorferi Group: Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.Sialoglycoproteins: Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Spleen: An encapsulated lymphatic organ through which venous blood filters.Arthrodesis: The surgical fixation of a joint by a procedure designed to accomplish fusion of the joint surfaces by promoting the proliferation of bone cells. (Dorland, 28th ed)Range of Motion, Articular: The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.Arthroplasty, Replacement: Partial or total replacement of a joint.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Immunologic Factors: Biologically active substances whose activities affect or play a role in the functioning of the immune system.Immunoconjugates: Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.Joint Prosthesis: Prostheses used to partially or totally replace a human or animal joint. (from UMDNS, 1999)Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Stifle: In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.Arthroplasty: Surgical reconstruction of a joint to relieve pain or restore motion.Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)Tuberculosis, Osteoarticular: Tuberculosis of the bones or joints.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Foot Deformities, Acquired: Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Elbow Joint: A hinge joint connecting the FOREARM to the ARM.Interleukin-10: A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Atlanto-Axial Joint: The joint involving the CERVICAL ATLAS and axis bones.Matrilin Proteins: PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.Hip Joint: The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Arthroscopy: Endoscopic examination, therapy and surgery of the joint.Chondrocalcinosis: Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)Matrix Metalloproteinases: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Sacroiliac Joint: The immovable joint formed by the lateral surfaces of the SACRUM and ILIUM.Hand Bones: The CARPAL BONES; METACARPAL BONES; and FINGER PHALANGES. In each hand there are eight carpal bones, five metacarpal bones, and 14 phalanges.Terpenes: A class of compounds composed of repeating 5-carbon units of HEMITERPENES.Aggrecans: Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Bursa, Synovial: A fluid-filled sac lined with SYNOVIAL MEMBRANE that provides a cushion between bones, tendons and/or muscles around a joint.

The MICA-A9 triplet repeat polymorphism in the transmembrane region confers additional susceptibility to the development of psoriatic arthritis and is independent of the association of Cw*0602 in psoriasis. (1/593)

OBJECTIVE: To investigate the relative contribution of HLA antigens in the susceptibility to psoriasis and to localize additional genetic factors involved in psoriatic arthritis (PsA). METHODS: DNA from 45 patients with psoriasis, 65 with PsA, and 177 healthy control subjects was examined by polymerase chain reaction (PCR) using sequence-specific oligonucleotide probes to determine HLA-C. To examine whether MICA (class I major histocompatibility complex chain-related gene A) confers additional susceptibility, trinucleotide repeat polymorphism in the transmembrane region of the MICA gene was investigated by radioactive PCR. Further analysis of MICA was made by PCR-single-strand conformational polymorphism to determine the allelic variant corresponding to MICA transmembrane polymorphism. RESULTS: Our results reveal new findings: 1) the frequency of the Cw*0602 allele was significantly increased in both patient groups: psoriasis (corrected P [Pcorr] < 10(-5), relative risk [RR] 6.2), PsA (Pcorr < 10(-6), RR 6.3), 2) the trinucleotide repeat polymorphism MICA-A9 was present at a significantly higher frequency in PsA patients (Pcorr < 0.00035, RR 3.2), whereas a similar distribution was found in both the control and psoriasis population, 3) this polymorphism corresponds to the MICA-002 allele and was found to be overrepresented in patients with the polyarticular form (Pcorr < 0.0008, RR 9.35), 4) the increase in MICA-A9 in PsA patients is independent of linkage disequilibrium with Cw*0602, 5) this allele confers additional relative risk (RR 3.27, etiologic fraction 0.44; etiologic fraction is the proportion of disease cases among the total population that are attributable to 1 allele when the relative risk is > 1) in PsA patients who carry Cw*0602. CONCLUSION: The data obtained in this study are consistent with the polygenic inheritance of psoriasis. Cw*0602 appears to be the stronger genetic susceptibility factor for psoriasis. Independent of the HLA-C association, MICA-A9 polymorphism corresponding to the MICA-002 allele is a possible candidate gene for the development of PsA.  (+info)

Collagenase, cathepsin B and cathepsin L gene expression in the synovial membrane of patients with early inflammatory arthritis. (2/593)

OBJECTIVE: To examine the expression of the matrix metalloproteinase, MMP-1, and the cysteine proteases, cathepsin B (CB) and cathepsin L (CL), in the synovial membrane (SM) of patients with early inflammatory arthritis. METHODS: Samples of SM were obtained by blind needle biopsy or needle arthroscopy from inflamed knees of 28 patients with early inflammatory arthritis (mean disease duration 10.2 months, range 2 weeks-18 months). Sixteen patients had rheumatoid arthritis (RA), nine psoriatic arthritis and there was one each with ankylosing spondylitis, gout and an undifferentiated arthritis. Comparison was made with tissue from two patients with established erosive RA and three normal synovial tissue samples. In situ hybridization was performed using digoxigenin-labelled RNA probes. RESULTS: MMP-1, CB and CL were expressed in all patients with early arthritis and in established erosive RA, whereas normal synovium showed only scanty expression. The three proteases were prominent in perivascular infiltrates and endothelial cells of early arthritis tissue. MMP-1 was observed primarily in the lining layer, but was also evident in the sublining area. CB and CL were expressed to a lesser extent in the lining layer, and were present mainly in the subintima. The three proteases were not found in lymphoid aggregrates. No differences were observed between the disease categories. CONCLUSIONS: The detection of MMP-1, CB and CL in the synovium shortly after symptom onset implies that the potential for joint destruction exists at a very early stage in the disease. In addition, the perivascular and endothelial cell expression suggests a role for these proteases in mononuclear cell influx to the inflamed synovium and in angiogenesis.  (+info)

Clinical and laboratory manifestations of elderly onset psoriatic arthritis: a comparison with younger onset disease. (3/593)

OBJECTIVE: Although the influence of age on clinical and laboratory features has been widely demonstrated in many arthropathies, studies on elderly onset (> 60 years) psoriatic arthritis (EOPsA) are rare. This study compares manifestations at onset and two year outcome of EOPsA with those of younger onset PsA (YOPsA). PATIENTS AND METHODS: Sixty-six consecutive PsA patients with disease duration < 1 year, 16 EOPsA (> 60 years) and 50 YOPsA (< or = 60 years) were admitted to a prospective study. Clinical, laboratory, and radiographic assessment were carried out at admission and after two years. HLA class I and bone scintigraphy were also recorded. In 10 patients with EOPsA and 24 with YOPsA it was possible to obtain synovial fluid, which was subsequently analysed for local inflammatory indices, including interleukin (IL) 1 beta, IL6, and IL8. RESULTS: Presenting manifestations of EOPsA differed from YOPsA in number of active joints (mean (SD)) (12.2 (6.3) v 6.7 (4.6), p < 0.001), foot bone erosions (2.7 (1.2) v 1.1 (1.1), p < 0.001), erythrocyte sedimentation rate (64.2 (35.3) v 30.5 (30.0) mm 1st h, p < 0.001), C reactive protein (3.9 (2.0) v 1.3 (1.3) mg/dl, p < 0.001) and synovial fluid IL1 beta (8.0 (4.7) v 3.0 (3.0) pg/ml, p < 0.001) and IL6 (828.2 (492.6) v 469.3 (201.4) pg/ml, p < 0.005). No differences were found in the number of subjects with dactylitis, pitting oedema, HLA-B27, or signs of sacroiliac and sternoclavicular joint involvement at bone scintigraphy. After two years, progression was more evident in EOPsA than in YOPsA, as the number of new erosions in the hands and also the C reactive protein were higher in EOPsA patients. CONCLUSION: PsA has a more severe onset and a more destructive outcome in elderly people (onset > 60 years) than in younger subjects. This behaviour may be influenced by immune changes associated with aging, as suggested by the higher concentrations of IL1 beta and IL6 found in the synovial fluid of EOPsA than in YOPsA.  (+info)

Excessive paternal transmission in psoriatic arthritis. (4/593)

OBJECTIVE: The differential expression of a disease according to the sex of the disease-transmitting parent has been demonstrated in several autoimmune disorders. The purpose of the present study was to determine whether there are differences in the transmission and expression of psoriatic arthritis (PsA) that are dependent on the sex of the affected parent. METHODS: All probands (patients with PsA) were identified from among the patients attending the University of Toronto Psoriatic Arthritis Clinic. A self-reported family history of psoriasis or PsA was noted for each proband. Differences in parental and offspring transmission with respect to the proband were evaluated. In addition, the expression of PsA according to the sex of the affected parent was assessed at the time of the proband's presentation to the clinic. RESULTS: Ninety-five probands had affected parents: 62 (65%) had an affected father, and 33 (35%) had an affected mother. Thus, the proportion of paternal transmission (0.65) was significantly greater than was expected (0.5) (P = 0.001). Twelve of 74 offspring from male probands (16.2%) were affected with psoriasis or PsA, as compared with 9 of 108 offspring from female probands (8.3%) (P = 0.10). Probands whose fathers were affected had a higher frequency of skin lesions prior to arthritis (P = 0.047), an erythrocyte sedimentation rate > 15 mm/hour (P = 0.044), and a lower incidence of rheumatoid factor (P = 0.044). No differences were noted with respect to age at the onset of psoriasis or PsA, the severity of the PsA, or the frequency of HLA antigens. CONCLUSION: There appears to be excessive paternal transmission in PsA. Further clinical confirmation and elucidation of its genetic basis is warranted.  (+info)

A comparative quantitative morphometric study of cell apoptosis in synovial membranes in psoriatic, reactive and rheumatoid arthritis. (5/593)

OBJECTIVES: Inflammatory arthritides/synovitides such as psoriatic (PsA), reactive (ReA) and rheumatoid (RA) arthritis share numerous immunopathological features, but develop different patterns of joint involvement. To investigate whether distinctive cell apoptosis may play a role in this context, we have assessed synovial cell apoptosis in situ in PsA and ReA, and compared it with RA and 'non-inflammatory' controls. METHODS: TdT-mediated dUTP nick end-labelling (TUNEL) of DNA breaks complemented immunoperoxidase staining for CD68 or LCA as the specific cell markers. RESULTS: The proportion of apoptotic synovial lining cells was high in PsA, ReA and RA compared to values in controls (P < 0.05). No differences existed between these inflammatory arthritides in numbers or type of apoptotic lining cells. In RA, however, in contrast to PsA and ReA, apoptotic lining cells were clustered or, in a small subset of samples, were very low in number. Prominent apoptosis of inflammatory cells in the sublining in ReA has accounted for higher overall apoptotic cell numbers in synovial stroma (sublining + perivascular inflammatory cell infiltrates) in this condition than in RA or PsA (P < 0.05). CONCLUSIONS: No disease-specific pattern in the phenotype of apoptotic synovial lining cells could be suggested in any of the inflammatory arthritides studied. However, topological differences in the lining and quantitative differences in the inflammatory cell apoptosis in synovial stroma may in part explain the occurrence of the prominent synovial lining cell hyperplasia distinguishing RA from ReA and PsA. On the other hand, relatively frequent inflammatory cell apoptosis may contribute both to the downregulation of synovial inflammation and to the control of synovial lining hyperplasia in ReA.  (+info)

SAPHO syndrome or psoriatic arthritis? A familial case study. (6/593)

OBJECTIVE: To discuss the relationships between SAPHO (synovitis, acne, pustulosis, hyperostosis and osteitis) syndrome and the group of spondylarthropathies. METHODS: Few reports of familial SAPHO have been published. We describe three children, two sisters and one brother, whose clinical and radiological presentation was in accordance with SAPHO syndrome. RESULTS: Two children developed psoriasis, and one child palmoplantar pustulosis. Both sacroiliac and sternoclavicular joints were involved in these three cases. Some features in our observations are also common to psoriatic arthritis. No association was found with HLA antigens, but a history of trauma preceding the onset of symptoms was present in all three children. CONCLUSIONS: We can consider that SAPHO is nosologically related to spondylarthropathies. Psoriatic arthritis could be the missing link between SAPHO and spondylarthropathies. It is likely that both genetic and environmental factors are involved.  (+info)

Chromosomal analysis of peripheral lymphocytes of patients before and after radiation synovectomy with samarium-153 particulate hydroxyapatite. (7/593)

OBJECTIVE: Radiation synovectomy may be indicated for the treatment of chronic synovitis. A number of factors may affect its current use, including availability, limited evidence for its efficacy compared to intra-articular glucocorticoid, and concerns regarding the potential long-term effects of radiation exposure, particularly in younger patients. Specific chromosome-type abnormalities in peripheral lymphocytes can be useful indicators of whole-body radiation exposure. The frequency of these aberrations has been shown to increase in patients who have had radiation synovectomy using yttrium-90 by up to five times compared to baseline levels. Samarium-153 particulate hydroxyapatite (Sm-153 PHYP) is a new radiopharmaceutical currently on trial which appears to have less extra-articular leakage than yttrium-90 compounds. The aim of this study was to identify any increase in specific chromosome-type abnormalities, using published criteria, in patients following Sm-153 PHYP synovectomy of the knee. The 10 patients (five men, five women) in whom the analyses were performed had a mean age of 47 yr (range 28-70 yr). RESULTS: There was no increase in scored chromosome-type abnormalities after Sm-153 PHYP synovectomy. CONCLUSION: This study further supports the relative safety of Sm-153 PHYP compared to other radiopharmaceuticals.  (+info)

Clinical, radiographic and HLA associations as markers for different patterns of psoriatic arthritis. (8/593)

OBJECTIVE: The aim of this study was to examine whether the five clinical forms of psoriatic arthritis (PsA) identified by Moll and Wright (Semin Arthritis Rheum 1973;3:55-78) could be clearly distinguished, especially as the disease evolved over time, to analyse whether radiographic features or HLA associations could define subsets with greater precision and to identify predictors of disease outcome. METHODS: Seventy-three patients (37 males and 36 females) were followed for a median time of 8 yr (range 1-16 yr). A standard clinical protocol was used to assess patients at each visit and two clinical scores. based on the joint areas involved, were defined to evaluate the mode of onset and the evolution of arthritis. X-ray films of the hands, feet and sacroiliac joints were taken and the patients were divided into two categories according to the presence or absence of erosions and an X-ray erosion score was also used. Three classification methods were used to define the different clinical subsets. HLA-A, B and DR antigens were tested by standard microlymphocytotoxicity assays. A multiple linear regression model was used in the statistical analysis. RESULTS: The five classical clinical subsets defined by Moll and Wright did not remain since distinct peripheral arthritis patterns tended to evolve over time. Only two discrete groups were identified, axial disease (AD) (sacroilitis with or without peripheral arthritis) in 29% of cases and peripheral disease (PD) without sacroilitis in 71%. AD was positively associated with the duration of arthritis (P < 0.04), presence of mutilation (P < 0.02) and the joint area score over disease evolution (JASE) (P < 0.02). There were erosions in 71% of the patients. Erosions correlated with the presence of mutilation (P < 0.007) and with the JASE (P < 0.0005). HLA-B27 was found in 43% of patients with AD, but only in 11% of PD patients (P < 0.01). No other clear HLA correlations were found. CONCLUSIONS: Despite the relatively small number of patients, this longitudinal study suggests that only two clinical subsets can be clearly defined in PsA, AD and PD; these are primarily determined on clinical grounds although HLA-B27 is strongly associated with AD. The evolution of PD pattern with time means that narrower peripheral arthritis subsets are of little clinical use.  (+info)

Like rheumatoid arthritis (RA), psoriatic arthritis is a chronic inflammatory disease of the joints and connective tissue. The disease causes joint pain and swelling that can lead to crippling along with inflamed and irritated scaly red patches of skin throughout the body. It is a progressive and debilitating disease and because there are no treatments specifically approved for psoriatic arthritis, doctors often use therapies approved for RA, including nonsteroidal anti-inflammatory drugs (NSAIDs) and disease modifying anti-rheumatic drugs (DMARDs). However, no DMARDs are currently approved for use in psoriatic arthritis. There are approximately 300,000 patients with psoriatic arthritis in the United States and the disease affects both men and women most commonly between the ages 30 and 50. Psoriatic arthritis patients are generally treated by rheumatologists and dermatologists ...
Other arthritis forms are rheumatoid arthritis , psoriatic arthritis , and related autoimmune diseases . Psoriatic arthritis may be difficult to distinguish from other forms of arthritis, particularly when skin changes are minimal or absent. In a small number of cases, it develops in the absence of noticeable skin changes . It is a chronic disease characterized by inflammation of the skin - psoriasis - and joints - arthritis.. Karason A, Love TJ, Gudbjornsson B. A strong heritability of psoriatic arthritis over four generations-the Reykjavik Psoriatic Arthritis Study. A genome-wide association study of psoriatic and psoriasis arthritis identifies new disease loci. The term inflammatory arthritis encompasses rheumatoid arthritis, reactive arthritis, psoriatic arthritis and ankylosing spondylitis. Acute and subacute bursitis Epicondylitis Acute nonspecific tenosynovitis Acute gouty arthritis Psoriatic arthritis Ankylosing spondylitis 3. The clinical course of peripheral and psoriatic axial ...
Celgene International Sàrl, a wholly-owned subsidiary of Celgene Corporation (NASDAQ:CELG), today announced results from a long-term (52-week) phase III trial of OTEZLA, the Companys oral, selective inhibitor of phosphodiesterase 4 (PDE4), in psoriatic arthritis patients who have not had prior treatment with systemic or biologic disease-modifying antirheumatic drugs (DMARDs). The data were presented at the European League Against Rheumatism Annual Congress (EULAR 2014) in Paris, France.. "Physicians need a variety of options to treat psoriatic arthritis, as treatment is highly individualized and some patients may not be appropriate candidates for biologics or certain systemic therapies," said Alvin Wells, M.D., Ph.D., director, Rheumatology and Immunology Center, Franklin, MN. "These efficacy and safety results suggest that OTEZLA monotherapy has the potential to be used for adults with active psoriatic arthritis in the first-line setting, prior to the initiation of DMARDtherapy, and possibly ...
1723 BRIEF REPORT TREATMENT OF PSORIATIC ARTHRITIS WITH ORAL 1,25-DIHYDROXYVITAMIN D,: A PILOT STUDY DAVID HUCKINS, DAVID T. FELSON, and MICHAEL HOLICK We conducted a 6-month open-label trial in which 10 patients with active psoriatic arthritis received 2 p g of oral 1,25-dihydroxyvitamin D3 daily. Statistically significant improvement was noted in the tender joint count and physician global impression. Of these 10 patients, 4 had substantial ( 2 5 0 % ) improvement, and 3 had moderate ( 2 2 5 % ) improvement in the tender joint count. Two patients were unable to receive therapeutic doses because of hypercalciuria. High-dose vitamin D may be a useful therapeutic agent for psoriatic arthritis. The principal therapies used in psoriatic arthritis are nonsteroidal antiinflammatory drugs (NSAIDs), prednisone, and, in some cases, antimalarial agents, gold salts, and methotrexate (1). All therapies have potential toxicity, and psoriatic arthritis is often difficult to treat effectively (I). Recently, ...
What is psoriatic arthritis? It is one of the less well-known forms of arthritis. As its name would indicate, psoriatic arthritis is associated with psoriasis, the common skin condition characterized by inflammation of the skin, scaling, and red raised patches of skin.. It is estimated that approximately 2 per cent of the Caucasian population in the United States are affected by psoriasis, even though it can occur in people from all backgrounds. The skin condition psoriasis most often affects the scalp, face, navel, tips of the elbows, knees, and areas surrounding the genitals and anus. Health professionals estimate that 10 per cent of all psoriasis patients concomitantly develop some form of inflammation in the affected joints. Consequently such patients are classified as suffering from psoriatic arthritis.. Risk Factors. Obviously, one of the major risk factors for developing psoriatic arthritis is the presence of the skin disorder, particularly if it affects the joints. Psoriatic arthritis ...
Confirm the diagnosis of "psoriatic arthritis" only by excluding other diseases with similar symptoms, such as osteoarthritis or rheumatoid arthritis.For example, the changes characteristic of psoriatic arthritis and do not occur in other diseases, detects X-rays.. If the analysis of synovial zhidkostiiz large joints, most often - a knee, show the presence of uric acid, it is likely that you have gout, psoriatic arthritis instead.. presence of inflammation, characteristic of psoriatic arthritis can prove a blood test for erythrocyte sedimentation rate (ESR).This figure has not yet been confirmed psoriatic arthritis itself, but only speaks of inflammation, so more research.. detection of rheumatoid factor (a special blood protein - antibody, which is produced against its own proteins circulating in the blood - antibodies, perceiving them as alien structure) in the presence of appropriate clinical picture confirms the diagnosis of rheumatoid arthritis, it is not found in psoriatic ...
BACKGROUND: Psoriasis and psoriatic arthritis (PsA) impair quality of life, including reduction in employment or job duties. The PRESTA (Psoriasis Randomized Etanercept STudy in Patients with Psoriatic Arthritis) study, a randomized, double-blind, two-dose trial, examined the efficacy of etanercept treatment in patients with moderate-to-severe plaque psoriasis and PsA and the main results have been presented previously. This analysis examined employment status, job duties and sick days, pre-defined endpoints in PRESTA, among this patient population. METHODS: Participants (N=752) were randomized to receive etanercept 50 mg twice weekly (BIW; n=379) or 50 mg once weekly (QW; n=373) for 12 weeks by subcutaneous injection. All participants then received open-label etanercept 50 mg QW for 12 additional weeks, while remaining blinded to the randomization. A pharmacoeconomic questionnaire was administered at baseline, week 12 and week 24 of treatment. The questionnaire included employment status and ...
Introduction: Potential hepatotoxicity associated with disease modifying anti-rheumatic drugs [DMARDs] requires laboratory monitoring. In rheumatoid and psoriatic arthritis [RA, PsA] patients, we examined the incidence of elevated alanine/aspartate aminotransferase (ALT/AST) enzymes associated with methotrexate (MTX), leflunomide (LEF), and MTX+LEF vs. other DMARDs.. Methods: RA and PsA patients enrolled in the Consortium of Rheumatology Researchers of North America (CORRONA) initiating DMARDs were identified. Abnormalities were identified when either was 1 or 2-fold time above the upper limits of normal (ULN). Odds ratios [OR] between MTX/LEF dose and elevated ALT/AST enzymes were estimated using generalized estimating equations. Interaction terms for use of MTX+LEF quantified the incremental risk of the combination compared to each individually.. Results: Elevated ALT/AST levels (,1x ULN) occurred in 22, 17, 31, and 14% RA patients receiving MTX, LEF, MTX+LEF, or neither, respectively; ...
Tumor necrosis factor alpha (TNF-alpha) is an important pro-inflammatory cytokine implicated in the pathogenesis of psoriatic arthritis. We have performed a case-control association study of three TNF-alpha gene polymorphisms in a group of Romanian psoriatic arthritis patients versus ethnically matched controls. A second group of patients with undifferentiated spondyloarthritis was used in order to look for similarities in the genetic background of the two rheumatic disorders. The −857C/T polymorphism was associated with susceptibility to psoriatic arthritis in our population at the individual level (p = 0.03, OR 1.65, 95% CI 1.05-2.57) and in combined haplotypes with the −238G/A and −308G/A SNPs. Regarding the investigated polymorphisms and derived haplotypes, no potential association was found with the susceptibility to undifferentiated spondyloarthritis in Romanian patients.
Psoriatic Arthritis merely Arthritis that can develop some people who experience the skin condition psoriasis. There are five main sorts of Psoriatic Arthritis- Symmetric Arthritis, Uneven Arthritis, Digital Interphalangeal Predominant (DIP) Arthritis, Arthritis mutilans additionally Spondylitis. In this article why dont we examine Treatments available. Generally discussion, Psoriatic Arthritis Treatment will be the same as Treatment for any different kind of Arthritis. Your doctor will advise on Treatment based on the type or types of their total condition you have and also the range and severity in all Symptoms. An early diagnosis will slow the progression on the disease and help to prevent further damage to the same joints. Ideally Treatment for Psoriatic Arthritis should work together with Treatment of skin psoriasis. Natural ...
Is there any marker for early detection of psoriasis in unaffected individuals? Whats the best course when severe psoriasis is refractory to conventional treatments in an HIV-positive patient? Cases in the literature and expert experience show that tumor necrosis factor inhibition can be effective and safe in selected patients with HIV. Update: Best Practice Recommendations for the Treatment of Nail Psoriasis. Exploring the Interleukin Connection in Psoriasis and Psoriatic Arthritis. Soumya Reddy, MD, co-director of the Psoriasis and Psoriatic Arthritis Center at NYU Langone Medical Center, explains the importance of staying alert to smoldering disease in patients whose inflammatory markers seem well-controlled. Hear the risk factors for psoriatic arthritis and get coping strategies. Tune in to learn all about the connection between psoriasis and psoriatic arthritis. One of the conundrums that comes up is that in about 10 percent of people, maybe even 15 percent, the arthritis symptoms will ...
If psoriasis has been diagnosed before or at the time the other symptoms of psoriatic arthritis are found, a diagnosis of psoriatic arthritis may be easily confirmed. However, when psoriatic arthritis symptoms precede symptoms of psoriasis, diagnosis is more difficult. Although psoriatic arthritis sometimes causes an elevated erythrocyte sedimentation rate (ESR), mild anemia, and elevated blood uric acid levels, these symptoms are also associated with other rheumatic diseases, including gout.. Other diagnostic tests may include:. ...
Background/Purpose: To date, although several have been proposed, there are no validated remission criteria in psoriatic arthritis (PsA). Validated criteria for minimal disease activity (MDA) in PsA have been established. This study aimed to compare sensivity and specificity of different potential remission criteria to identify patients in remission as defined by musculoskeletal ultrasound (US).. Methods: In this cross sectional study PsA patients were consecutively recruited from an outpatient clinic. All the patients fulfilled the CASPAR criteria for PsA. The following potential remission criteria were assessed: (1) Disease Activity Index for Psoriatic Arthritis (DAPSA) ≤3.3, (2) Composite Psoriasis Disease Activity Index (CPDAI) ,2, (3) Psoriatic ArthritiS Disease Activity Score (PASDAS) ,2.4 (4) Booleans definition of remission modified for PsA, meeting all of the following criteria: 68 tender joints (TJC68) ≤1, 66 swollen joints (SJC66)≤1, Maastricht Ankylosing Spondylitis Enthesitis ...
|p|In RAPID-PsA (NCT01087788) certolizumab pegol (CZP) improved signs and symptoms of psoriatic arthritis (PsA) over 4-years treatment.|/p|
Abstract: P1633 - Psoriasis and psoriatic arthritis multidisciplinary unit: three. We report our experience in the multidisciplinary unit of Dermatology and Rheumatology during the last three years. Multidisciplinary Focus on Methotrexate in Psoriatic Disesase ANTONIO MARCHESONI,. There is a need to screen psoriasis patients early for symptoms of PsA. Methods: The questionnaire (PASE; Psoriatic Arthritis Screening and Evaluation) was developed using standardized methodology for the development of both functional and health-related instruments geared toward musculoskeletal diseases. A multidisciplinary team of dermatologists, rheumatologists, and patient focus groups were involved in the design of the questionnaire. Patients with psoriatic arthritis are also at higher risk for psychological distress of anxiety and depression 1. While existing studies 10 - 12 investigate the effects of nursing education on the management of psoriasis, these studies do not focus on the specific type of psoriasis, ...
Methods Material and methods: Prospective study on 88 (37 M/51 W) consecutive PsA fulfilled CASPAR criteria. All the patients were evaluated according to a predefined protocol that included:rheumatology and dermatology clinical evaluation and functional disability ( Health Assessment Questionnaire, HAQ, quality of life score- Short Form36, SF36), PASI and VAI based on Waist Circumference (WC), Body Mass Index (BMI), triglycerides (TG) and HDL cholesterol (HDL) levels. BMI was calculeted in 4 standard categories according to WHO criteria and WC was calculeted according to WHO (cut points 94 cm for men and 80 cm for women).. ...
When psoriasis has been diagnosed, a diagnosis of psoriatic arthritis may be easily confirmed. However, when psoriatic arthritis symptoms precede symptoms of psoriasis, diagnosis is more difficult. Although psoriatic arthritis sometimes causes an increased erythrocyte sedimentation rate, or ESR, mild anemia, and elevated blood uric acid levels, these symptoms are also associated with other rheumatic diseases, including gout. ESR is a measurement of how quickly red blood cells fall to the bottom of a test tube. When swelling and inflammation are present, the bloods proteins clump together and become heavier than normal. Thus, when measured, they fall and settle faster at the bottom of the test tube. Generally, the faster the blood cells fall, the more severe the inflammation.. ...
In our study, physical health at last assessment in patients with juvenile PsA was poorer than in controls and patients with either oligoarticular or polyarticular JIA, but not poorer than those with ERA. Physical limitations worsened from a median of 15 to 23 years of disease duration in PsA patients only. The need for DMARD and/or anti-TNF agents after 23 years was greater in patients with PsA than in those with oligoarthritis and tended to be greater than in those with polyarthritis. A history of psoriasis in a patient or firstdegree relative, dactylitis, and ankle or toe arthritis within the first 6 months were early predictors of PsA in children with all JIA subtypes. Additionally, onset after the age of 6 years and HLA-DRB1*11/12 status differentiated PsA patients from those with either oligoarthritis or polyarthritis. PsA patients were younger at onset, comprised fewer men, and were more often HLA-DRB1*11/12-positive and less often HLA-B27-positive than those with ERA. To date, this is ...
Approximately five to seven percent people diagnosed with psoriasis develop psoriatic arthritis. The association between psoriasis and psoriatic arthritis is
The U.S. Food and Drug Administration (FDA) has approved an expanded indication for ENBREL(R) (etanercept) to inhibit the progression of structural da
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Psoriasis affects 7.5 million Americans, with 18-42% of these people later developing psoriatic arthritis. This month, the U.S. Food and Drug Administration (FDA) approved a new treatment option for this difficult condition. Ixekizumab (Taltz) from Eli Lilly and Company is now approved as an injection for the treatment of adults with active psoriatic arthritis. Taltz…
In a randomized clinical trial conducted by researchers at Stanford and more than 100 other medical centers, psoriatic arthritis patients given an injectable biologic drug for 24 weeks showed substantial improvement compared with patients who received placebo injections.
This arthritis tends to be worse after exercise. Psoriatic Arthritis treatment of rheumatism arthritis can one finger only Acupuncture Research Mp Joint bursitis is defined as "inflammation or irritation of It is located between bones muscles tendons and skin. arthritis osteoporosis associates freehold nj hip heat treatment 448-arthritis-center-hattiesburg Symptoms and Complications. These plastic or metal prostheses are used by some hand surgeons to replace the arthritic joint. To treat psoriasis in patients with psoriatic arthritis systemic corticosteroids are not typically recommended because there is a potential for "post-steroid psoriasis flare.. Treating arthritis from the perspective of natural remedies does not differentiate much between the different types of Regular exercise is recommended to stimulate the digestive Living Life Free From Pain: Treating Arthritis Joint Pain Muscle Pain and Fiomyalgia with Maharishi Chapter 84 Biologics in paediatric rheumatic How exactly does arthritis ...
Psoriatic arthritis is a form of arthritis that affects around 10 to 30% of people who have psoriasis. Usually, people who have psoriatic arthritis will have a history of Psoriasis but in some people, joint problems can begin before skin lesions appear.
The use of flaxseed oil in acne treatment is sensible there are several theories that flax helps solve psoriasis and eczema may benefit from flaxseed oil. Psoriatic Arthritis Numb Fingers During Pregnancy Symptoms had very bad Psoriasis on my head and arms this really helped me and could really help Psoriatic Arthritis Numb Fingers During Pregnancy Symptoms you also! tinyurl.com/n22nejl Itching especially during Plaque psoriasis causes patches of thick Herpes simplex virus infection and Intracranial infections causing vertigo Symptom Checker Did You Know? ayurvedic treatment for eczema in infants early guttate stages Anyone can get head lice not just kids. Cirrhosis of the liver Stress; Immunisation; Health Checks; Often especially in the early stages of liver cirrhosis Frequently Asked Questions About Psoriasis .. New techniques that can identify fingerprints for specific diseases and specific Arthritis Treatment Yoga most importantly containing natural rubber latex. Home; Log In; Account; ...
Secukinumab for ankylosing spondylitis and psoriatic arthritis Ennio Lubrano, Fabio Massimo Perrotta Dipartimento di Medicina e Scienze della Salute “Vincenzo Tiberio”, Università degli Studi del Molise, Campobasso, Italy Abstract: The treatment of ankylosing spondylitis (AS) and psoriatic arthritis (PsA) positively changed since the introduction of anti-TNFα drugs. These treatments were shown to reduce the symptoms and signs of the diseases and improve the quality of life. However, a variable percentage of patients do not respond to anti-TNFα or can exhibit a loss of response and, furthermore, despite anti-TNFα drugs’ proven efficacy in reducing peripheral radiographic progression in PsA, the impact in reducing radiographic damage in AS is still debated. Recently, the discovery of new pathogenic mechanisms paved the way to the development of new drugs that target other pro-inflammatory cytokines. In particular, the inhibition of interleukin (IL)-17, which is
The Psoriasis and Psoriatic Arthritis Alliance (PAPAA) meets the criteria for NIHR Partner Organisation status for its Research Grants funding stream.. Therefore, the Psoriasis and Psoriatic Arthritis Alliance is an NIHR Partner Organisation in respect of its Research Grants funding stream. Studies funded through this funding stream are eligible for inclusion in the NIHR Clinical Research Network Portfolio and therefore able to access NHS support via the NIHR Clinical Research Network infrastructure. You can find further information about the NIHR Clinical Research Network Portfolio at ...
Psoriasis and psoriatic arthritis symptoms were significantly lessened in patients who underwent bariatric surgery, according to researchers from NYU Langone Medical Center. The studys authors suggest that the findings indicate that losing excess weight may improve symptoms in people who have these lifelong conditions. The researchers believe that obesity may contribute to the risk for development of psoriasis and psoriatic arthritis through fat tissue-driven systemic inflammation.
Curious how the new Treatment Guideline for Psoriatic Arthritis impacts you? Hear one of the leading authors of the treatment guideline -- rheumatologist, Dr. Alexis Ogdie Beatty, present key points and evidence that served as the basis for the guideline from the American College of Rheumatology and the National Psoriasis Foundation. Learn what changes may be relevant to the management of your psoriatic arthritis. ...
If you have psoriasis you might be prone to Psoriatic Arthritis. Only people with psoriasis suffer from this kind of Arthritis. Check out our website to learn more about Psoriatic Arthritis.
TY - JOUR. T1 - Predictors of early minimal disease activity in patients with psoriatic arthritis treated with tumor necrosis factor-α blockers. AU - Iervolino, Salvatore. AU - Di Minno, Matteo Nicola Dario. AU - Peluso, Rosario. AU - Lofrano, Mariana. AU - Russolillo, Anna. AU - Di Minno, Giovanni. AU - Scarpa, Raffaele. PY - 2012/3. Y1 - 2012/3. N2 - Objective. To identify predictors of early minimal disease activity in patients with psoriatic arthritis (PsA) receiving tumor necrosis factor-&αλπηα; (TNF-α) antagonists. Methods. In total 146 consecutive patients with PsA eligible for anti-TNF- &αλπηα; therapy were enrolled. At baseline (T0) information about age, sex, PsA subset, disease duration, comorbidities, and treatments was collected. All subjects were tested for metabolic syndrome (MetS) and/or liver steatosis. A clinical and laboratory evaluation was performed at T0 and at 3 months (T3). Changes in all these variables were compared in subjects achieving minimal disease ...
Over the past 30 years, there has been increasing recognition of psoriatic arthritis as a distinct clinical entity. Psoriatic arthritis occurs mostly in patients with psoriasis and may affect up to 1% of the general population. It has many similarities to other forms of spondyloarthritis, and must be differentiated from related conditions.
There is no cure for psoriatic arthritis, hence treatment aims at reducing the inflammation of the affected joints for preventing joint disability and pain. Usually, a multidisciplinary approach is used for treating both joint and skin symptoms.. Medications for psoriatic arthritis include:. Anti-inflammatory Drugs. Drugs like ibuprofen and aspirin helps in controlling the swelling, pain and morning stiffness, and they are generally the first treatments tried for this condition. Prescribed anti-inflammatory drugs are very effective than over the counter medications. But most anti-inflammatory drugs may irritate intestine and stomach, and usage of these medications for long period may cause gastrointestinal bleeding and ulcers.. Other side effects are heart failure, damage to the kidneys and fluid retention. Additionally, anti-inflammatory drugs worsens the skin conditions. Yet, these drugs are beneficial for people with minor stiffness and joint pains.. Corticosteroids. Physician may prescribe ...
The TICOPA trial is designed as a randomised, controlled, parallel group, open label, multi-centre clinical trial of 206 patients with recent onset psoriatic arthritis. Patients will be randomised on a 1:1 basis to receive either standard care (12 weekly review) or tight control (4 weekly review) for a period of 48 weeks. The hypothesis is that tight control of inflammation will lead to a better outcome in terms of joint inflammation, joint damage, pain and quality of life for people with PsA. This imaging undertaken within the study will provide a further measure of joint inflammation and damage and will improve understanding of the relationships between inflammation, damage and bony proliferation in psoriatic arthritis.. Those subjects randomised to the tight control arm will be reviewed every 4 weeks (by the PI at each site or a designated researcher), and will be treated according to a rapidly escalating regime, involving standard DMARDs and biologics. Initial therapy will be with oral ...
Psoriasis is a skin disease that causes itchy or sore patches of thick, red skin with silvery scales. You usually get them on your elbows, knees, scalp, back, face, palms and feet, but they can show up on other parts of your body.. Some people with psoriasis have psoriatic arthritis. It causes pain, stiffness, and swelling of the joints. It is often mild, but can sometimes be serious and affect many joints. The joint and skin problems dont always happen at the same time.. Your doctor will do a physical exam and imaging tests to diagnose psoriatic arthritis. There is no cure, but medicines can help control inflammation and pain. In rare cases, you might need surgery to repair or replace damaged joints.. ...
Good news for the approximately two million Americans with psoriatic arthritis (PsA). Those with active disease now have two new treatment options: the U.S. Food and Drug Administration (FDA) in December approved both ixekizumab (Taltz) and tofacitinib (Xeljanz) for the treatment of PsA.. Continue reading FDA Approves Two New Drugs for Psoriatic Arthritis →. ...
Tony Sampson, Mercer University College of Pharmacy It is suggested that psoriatic arthritis is a chronic inflammatory autoimmune disease that targets both skin and nail and affects approximately 0.005 percent of the general population. [1] According to The American College of Rheumatology, current treatment for psoriatic arthritis includes non steroidal anti-inflammatory drugs, disease modifying anti-rheumatic…
Psoriatic arthritis is a diseased situation that causes swelling in the joints and can outcome in great pain and as well scaly patches on the skin. It is commonly connected to the skin condition psoriasis and can as well cause problems with other parts of the body, like the elbows, scalp, and knees.
Psoriatic arthritis is a diseased situation that causes swelling in the joints and can outcome in great pain and as well scaly patches on the skin. It is commonly connected to the skin condition psoriasis and can as well cause problems with other parts of the body, like the elbows, scalp, and knees.
|p|Psoriatic arthritis is an inflammatory, autoimmune disorder that causes stiffness, pain and swelling in the joints and affects about 30 percent of those with psoriasis. Learn about psoriatic arthritis including symptoms, treatment options and easy lifestyle changes that can provide some relief. |/p|
There are several over-the-counter (OTC) and prescription medicines for psoriatic arthritis. Some treat symptoms of both psoriasis and psoriatic arthritis, others target skin problems, yet others help with joint issues.
Do you know why we conduct clinical trials for psoriatic arthritis in Birmingham? Psoriatic arthritis is a chronic inflammatory autoimmune disease.
[40 Pages Report] Check for Discount on Psoriatic Arthritis - Epidemiology Forecast to 2025 report by Delve Insight. DelveInsight s Psoriatic Arthritis -Epidemiology Forecast, 2025 provides an overview...
Came across this blog when I was trying to figure out if the new nerve pain shooting from the bottom of my foot to my knee cap was related to my psoriatic arthritis and shes had similar pain. When I research nerve pain and psoriatic arthritis, I find website that go into ...
Psoriatic arthritis pain can be treated. Get more information on the causes, symptoms, diagnosis, and medications for psoriatic arthritis.
Psoriatic arthritis is an invisible disease and can make you feel lonely. Watch these videos to meet others living with psoriatic arthritis and hear how they manage the condition.
Question - Have psoriatic arthritis and hypothyroidism. Noticed painless hard lump on clavicle. What it could be?. Ask a Doctor about diagnosis, treatment and medication for Psoriatic arthritis, Ask a General & Family Physician
Cynthia Covert was diagnosed with psoriatic arthritis in 2003. Since then, she has learned ways to manage her pain whenever she leaves home. Here are some of her tips for dealing with psoriatic arthritis on the go.
It was Ball in 1971 who primarily set the foundations for the significance of enthesitis in SpA, by suggesting that the enthesis is centrally affected in ankylosing spondylitis (AS) patients, while the synovial joint is the main target of the inflammatory involvement in rheumatoid arthritis (RA) patients [29]. A few decades later, McGonagle and colleagues contributed significantly to the understanding of enthesitis as a key feature in SpA [16, 30]. Over the years, this idea was recognized by different organizations as the Assessment of Spondyloarthritis International Group (ASAS) that included it in their classification criteria for both axial and peripheral SpA and by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) who included it in the stem requirements of the CASPAR criteria [21, 31, 32].. The current study provides novel data regarding the association between enthesitis and features of severity in patients with PsA. The study found that a higher MASEI ...
Ixekizumab significantly improves symptoms of psoriatic arthritis in patients naive to prior biologic therapy and in patients who had failed prior to biologic therapy.
The aim of this observational study will be to recruit 100 Psoriatic Arthritis (PsA) patients beginning on their biologic therapy and asses, both clinically and with the use of ultrasound (US), how enthesitis responds to biologic treatment.. The decision to start treatment with a biologic therapy will be made by the patients usual clinical rheumatology team, as part of their standard clinical care. This is independent of the study. Patients in whom treatment with these drugs for their PsA has been recommended will then be invited to participate in this study.They will then be commenced on biologic therapy at doses in line with the Summary of Product characteristics (SPC) for the product and followed up in the hospital outpatient clinic.. Patients will have a full history taken and clinical exam performed prior to commencing on their prescribed biologic. The patients history, Health Assessment Questionnaire scores and biobanking samples will be taken by the co-investigator. They will also ...
OBJECTIVE: To characterize the diversity and taxonomic relative abundance of the gut microbiota in patients with never-treated, recent-onset psoriatic arthritis (PsA).METHODS: High-throughput 16S ribosomal RNA pyrosequencing was utilized to compare the community composition of gut microbiota in patients with PsA (n = 16), patients with psoriasis of the skin (n = 15), and healthy, matched control subjects (n = 17). Samples were further assessed for the presence and levels of fecal and serum secretory IgA (sIgA), proinflammatory proteins, and fatty acids.RESULTS: The gut microbiota observed in patients with PsA and patients with skin psoriasis was less diverse when compared to that in healthy controls. This could be attributed to the reduced presence of several taxa. Samples from both patient groups showed a relative decrease in abundance of Coprococcus species, while samples from PsA patients were also characterized by a significant reduction in Akkermansia, Ruminococcus, and Pseudobutyrivibrio. ...
A recent study reports that obesity is linked to late-onset psoriasis and psoriatic arthritis (PsA). By contrast being of normal weight may be associated with an earlier onset of the disease adn HLA-B27.. Patients with early PsA were compared to those without arthritis (PsC), with regard to their body mass index (BMI) and HLA risk alleles for psoriatic disease (HLA-B*27, B*3901, B*3801, B*0801, B*4402, B*4403, and C*0602). A case-controlled designed was utilized to detect associations. Obesity was more common among the 314 patients with early PsA compared to 498 PsC patients (OR 1.77; p = 0.002).. Higher BMI was significantly associated with older age at onset for both PsA and psoriasis (p = 0.009).. HLA-B*27 was higher in patients with normal weight compared with those with higher BMI (p = 0.002).. Body weight significantly influences the onset and expression of psoriatic disease. ...
Dactylitis, commonly referred to as "sausage-shaped" fingers and toes, is considered a hallmark of psoriatic arthritis. Psoriasis is a multifactorial inflammatory disease that may affect the spine, sacroiliac joints, and peripheral joints.1 Up to 20% of patients with psoriatic arthritis will develop disabling arthritis. Joint damage may be seen both clinically and radiographically and can lead to a decreased quality of life. Other common clinical features of psoriatic arthritis include synovitis and enthesitis. Dactylitis results from peritendinous soft tissue edema.2. Dactylitis may affect multiple digits simultaneously and may be the initial sign of psoriatic arthritis. It is frequently accompanied by nail changes, pain on palpation, tenderness, and soreness.2,3 Biologic therapies reduce the production of damaging cytokines and may limit progression of joint disease.4. ...
The interleukin-17A antagonist ixekizumab has been approved by the Food and Drug Administration for treating adults with active psoriatic arthritis (PsA), based
Patients with active psoriatic arthritis treated with secukinumab for 2 years in the FUTURE-1 trial experienced sustained decreases in disease activity and symptoms, leading to improvements in physical function and quality of life.
Rheumatism is a traditional and non-specific term used in the East and West to see a variety of pains affecting the bones, articulations, skin, heart, kidneys, bronchi. This term is rapidly to fall out of favour in the western world today because modern healing system has discovered that almost all these conditions have plenty aetiologies (causes) requiring many Treatments. You can say they are word mainly used during the Chinese (& traditional) organizations; its also used because of a minority of Westerners into homeopathic and complementary treatment. The only common characteristics among these weather conditions are: 1) they cause maintained chronic pain, and 2) they are very difficult to treat. Arthritis is a broad term refers to inflammed joints, but doesnt say anything virtual cause. Includes conditions like OsteoArthritis, Rheumatoid Arthritis, Psoriatic Arthritis, infective Arthritis, gouty Arthritis, etcetera. Generally, Id divide Arthritis to bar 2 big groups: 1) OsteoArthritis ...
Individuals with Pannus Psoriatic Arthritis Vs Rheumatoid Arthritis Injections and Osteoarthritis often times have an elevated erythrocyte alluviation level or even D Responsive Healthy proteins, which will may suggest the employment of a great incitive activity within the body. Additional popular circulation testing try to look for rheumatic aspect plus anti-cyclic citrullinated peptide antibodies. A physician could advocate 10 Shaft of light to help you record a further development of rheumatoid arthritis symptoms symptoms in your own outlets around time. MRI plus echography testing might help a family doctor decide a harshness of the sickness inside your body.. ...
This page provides relevant content and local businesses that can help with your search for information on Arthritis Specialists. You will find informative articles about Arthritis Specialists, including Psoriatic Arthritis. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Batavia, IL that can help answer your questions about Arthritis Specialists.
This page provides relevant content and local businesses that can help with your search for information on Arthritis Specialists. You will find informative articles about Arthritis Specialists, including Psoriatic Arthritis. Below you will also find local businesses that may provide the products or services you are looking for. Please scroll down to find the local resources in Greeley, CO that can help answer your questions about Arthritis Specialists.
Evidence-based recommendations on etanercept (Enbrel) infliximab (Remicade) and adalimumab (Humira) for treating active and progressive psoriatic arthritis
Evidence-based recommendations on etanercept (Enbrel) infliximab (Remicade) and adalimumab (Humira) for treating active and progressive psoriatic arthritis
Psoriatic arthritis (PsA) is a form of inflammatory arthritis (IA) affecting approximately 0.25% of the population. It is a heterogeneous disorder associated with joint damage, disability, disfiguring skin disease and in severe cases, premature mortality. Inherently irreversible and frequently progressive, the process of joint damage begins at, or before, the clinical onset of disease. Early recognition and intervention is thus crucial to patient outcome. At disease onset, however, PsA often resembles other forms of arthritis-especially rheumatoid arthritis (RA). Despite the similarities between PsA and RA, their distinctive pathologies require different treatments. For example, drugs that are effective in RA may not be effective in PsA and can even cause adverse effects. Since there is no currently validated test for PsA, the diagnosis is often missed or delayed and this has functional consequences for the patient. In the context of PsA and RA, making an accurate diagnosis is not the only ...
OBJECTIVE: To compare the prevalence of cardiovascular diseases and their risk factors between patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) and control subjects. METHODS: Data for patients continuously enrolled in an integrated outcomes database between January 1, 2001, and December 31, 2002, with International Classification of Diseases, 9th Revision codes of 714.x (RA), 696.0 (PsA), or 720.0 (AS) were evaluated in this cross-sectional comparative study. Control groups were established for each patient group (1:4 ratio) by matching on the basis of age, sex, geographic region, and length of time in plan. Age- and sex-adjusted prevalence of cardiovascular comorbidities and risk factors were calculated; the prevalence ratio of the comorbidities and risk factors for the patient groups compared with the control population were estimated. Use of selected cardiovascular medications was also compared between patient and control groups. RESULTS: The ...
Psoriasis is a relatively common skin condition. A number of HLA antigens are associated with psoriasis. When psoriatic patients carry the antigen HLA-B27, there is a high risk to develop psoriatic spondylitis. When they are positive for the antigen HLA DR4 they are more liable to develop an arthritis. Psoriatic arthritis a common complication occurring in 5% of psoriatics ...
Switching biologic disease-modifying anti-rheumatic drug (bDMARD) therapy after failure of a first bDMARD for the treatment of psoriatic arthritis (PsA) can be effective, according to a review of the literature and PsA consensus treatment recommendations.. Investigators led by Joseph F. Merola, MD, from Harvard Medical School, Boston, conducted a literature review to determine the efficacy and safety related to switching between bDMARDs in the treatment of PsA, and they evaluated PsA treatment recommendations from national rheumatology societies to identify consensus guidelines on switching.. They noted that "data from the clinical literature on switching bDMARD therapies in PsA are limited," with most studies being observational or retrospective. Treatment responses have been decreased when switching from one tumor necrosis factor inhibitor (TNFi) to a second or third TNFi, and the patient characteristics that predict efficacy after switching arent clear, they wrote online in Seminars in ...
Pfizer is currently recruiting for the NCT02984020 Rheumatoid Arthritis, Psoriatic Arthritis Cancer trial. Review trial description, criteria and location information here.
Psoriatic arthritis drug treatment often involves powerful and side-effect ridden drugs. Many psoriasis patients are often unaware of the risks of these drugs.
New PSUMMIT 2* data further demonstrate the efficacy of ustekinumab in Psoriatic Arthritis (PsA). The data was first presented at EULAR 2013.
Anti arthritis Herbal Ms are open online for your favorite herbal medicine for order the best in herbal nutritional supplements. Psoriatic arthritis anti ccpPublications & Communications - rheumatology.org.
Psoriatic arthritis (PsA) is a relapsing inflammatory joint condition associated with psoriasis that affects about 1-3% of the world overall, but with widely varying incidences in different populations. It is a severe and sometimes debilitating complication of psoriasis.
OBJECTIVE: To include the patient perspective in accordance with the Outcome Measures in Rheumatology (OMERACT) Filter 2.0 in the updated Psoriatic Arthritis (PsA) Core Domain Set for randomized controlled trials (RCT) and longitudinal observational studies (LOS).. METHODS: At OMERACT 2016, research conducted to update the PsA Core Domain Set was presented and discussed in breakout groups. The updated PsA Core Domain Set was voted on and endorsed by OMERACT participants.. RESULTS: We conducted a systematic literature review of domains measured in PsA RCT and LOS, and identified 24 domains. We conducted 24 focus groups with 130 patients from 7 countries representing 5 continents to identify patient domains. We achieved consensus through 2 rounds of separate surveys with 50 patients and 75 physicians, and a nominal group technique meeting with 12 patients and 12 physicians. We conducted a workshop and breakout groups at OMERACT 2016 in which findings were presented and discussed. The updated PsA ...
Many patients with psoriasis and psoriatic arthritis are not benefiting from the expanding array of treatments now available to combat these serious autoimmune disorders, researchers led by a UC Davis dermatologist report in a new study published online today by JAMA Dermatology.
Conway R, Low C, Coughlan RJ, ODonnell MJ, Carey JJ. Methotrexate use and risk of lung disease in psoriasis, psoriatic arthritis, and inflammatory bowel disease: systematic literature review and meta-analysis of randomised controlled trials. BMJ. 2015;350:h1269. 25770113 ...
Doctors give unbiased, trusted information on the use of C Reactive Protein for Arthritis: Dr. Oleary jr on psoriatic arthritis crp esr: Synovial tissue inside joints become inflamed and damaged by chronic inflammation. The exact triggers are still elusive.
First-in-class oral treatment for psoriatic arthritis made available via the National Health Service (NHS) STOCKLEY PARK, England--(BUSINESS WIRE)-- ...
The goal of this activity is to educate pharmacists and pharmacy technicians about pharmacist interventions in improving the quality of life for patients with psoriasis and psoriatic arthritis. Readers will also gain knowledge about available options for treatment, adverse effects, risks, and benefits.
If you have psoriasis, what are your chances of getting psoriatic arthritis? Thanks to new scientific discoveries, we may soon find out.
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Psoriatic arthritis, as the term suggests, is a type of arthritis that is linked with psoriasis (it is chronic skin condition that features reddened scaly
Psoriatic arthritis is another form of rheumatoid arthritis which may appear in almost 30% of the patients who are suffering from the common skin disorder known as
If youre experiencing arthritis symptoms, identifying the type can help guide your treatment. Heres how psoriatic arthritis and osteoarthritis differ.
I have been on MTX 3 times over the last 10 years. The first time was solely for Psoriasis. I was on the pills and did experience some nausea, but taking them at night was enough help for me to not be in too much discomfort. I took solely MTX for about 6 months and it worked well on my Psoriasis. During this time I was diagnosed with Psoriatic Arthritis and it was decided to put me on Enbrel and drop the MTX. The second time I was on it I was on Remicade and it was added to try to increase the effectiveness of the Remicade and prolong the amount of time that I could stay on Remicade as I was at max dose max/frequency of Remicade. This time I started with the pills and experienced severe nausea and headaches. I was switched to the shot form and again taking it at night and the nausea reduced and I no longer had migraine level headaches. After about a year the combo of Remicade and MTX was causing my liver function tests to come back high so it was decided to stop the MTX. The final time was after ...
Results We present this case of a girl who at 11 months suffered from discrete red scaly areas on the trunk, limbs and scalp. She was given a diagnosis of psoriasis which remained poorly controlled throughout childhood, despite phototherapy and methotrexate treatment.. In infancy, slow gross motor development was noted and felt to be related to hypermobility. She also began complaining of morning stiffness and pain in her hands and knees. The ESR was slightly raised at 17 but all other investigations were negative including ANA, rheumatoid factor and HLA-B27. X-rays showed osteopenic bones but no joint erosion. A diagnosis of psoriatic arthritis was made and although wheelchair bound, she never had significant joint inflammation.. Dental concerns also emerged with delayed eruption and very malformed teeth with short roots. She was of proportional short stature with height at the 3rd centile at 10 years.. At 11 years a systolic murmur was first heard although she had no cardiac symptoms. An ...
30 yrs old Male asked about Psoriatic arthritis, 1 doctor answered this and 49 people found it useful. Get your query answered 24*7 only on | Practo Consult
Psoriatic arthritis occurs in people who have a skin condition called psoriasis. Some people develop severe joint damage from this autoimmune disorder.
Psoriatic arthritis occurs in people who have a skin condition called psoriasis. Some people develop severe joint damage from this autoimmune disorder.
EXTON, Pa., Sept. 26, 2017 /PRNewswire/ -- Analysis of Over 1000 Psoriatic Arthritis (PsA) Patients Reveals Large Candidate Pool for Pfizers Xeljanz, BMS Orencia, and Eli Lillys Taltz. According to Spherix Global Insights, the analysis indicates an increase in biologic switching rates compared
Psoriatic arthritis often develops in people who also have psoriasis, which is an autoimmune disease that causes the immune system to go into overdrive and atta...
Patients with psoriatic arthritis more often stayed on treatment if given a biologic agent, depression is frequently transient in patients with scleroderma, and childhood-onset morphea differs from th
Psoriatic arthritis (PsA) can contribute to some mental health conditions, including depression. In this article, we look at the link between PsA and depression, as well as treatments and coping strategies.
Best natural remedies for Psoriatic Arthritis, which will not fail in curing the joint inflammation, are listed in the following article. About 6 to 42% of
Diagnosis and conservative treatment of psoriatic arthritis (costs for program #276994) ✔ University Hospital Jena ✔ Department of Nephrology, Rheumatology, Osteology and Endocrinology ✔ BookingHealth.com
Inflammatory pain is a component of psoriatic arthritis, and participating in physical activity, such as yoga, is a way to reduce inflammation and manage chronic pain if a patient is experiencing it.
When you hurt, often the last thing you want to do is work out. Yet exercise is one of the best things you can do for your joints. Staying fit keeps joints limber. It also helps you lose weight, which takes pressure off your joints. The best exercises for psoriatic arthritis are those that are gentle on joints, such as yoga, tai chi, and swimming. Working out in warm water can also help soothe joint soreness. Ask your doctor which exercises are best for you. The doctor might recommend that you see a physical therapist to help you start an exercise program. The physical therapist can teach you how to do each movement safely and correctly.. ...
The proposed PsA Treatment Guideline - which contains around 80 recommendations - will undergo final review prior to consideration for publication in 2018.
You know about flare-ups and pain, but there are other complications of psoriatic arthritis you might not know about. Here are 10 uncommon PsA complications you should watch out for, including back pa
Figure 3: Hand and finger joints.. In psoriatic arthritis, unlike RA, there is a tendency for involvement of joints on one side of the body (asymmetry) without involvement of the opposite side. For example, a person with psoriatic arthritis may have arthritis in the right thumb joints but not the left thumb joints.. The inflammation of psoriatic arthritis produces what is typically described as a "sausage-like" swelling of the fingers. In addition to possibly involving the hand and other peripheral joints (such as the elbow or knee), psoriatic arthritis can cause inflammatory damage to the spine and sacroiliac joints of the pelvis with associated back pain and stiffness. See Can I Get Social Security Disability Benefits for Back Pain?. There are no diagnostic tests for psoriatic arthritis. Increased uric acid levels may lead to a false diagnosis of gout.. X-ray evaluation is helpful in diagnosis. Psoriatic arthritis will tend to show asymmetric joint abnormalities, involvement of distal ...
Psoriasis causes painful and uncomfortable patches of infected pores and skin. Typically these patches can crack and bleed.. If psoriasis begins to have an effect on folkss joints, its known as psoriatic arthritis. Psoriatic arthritis may cause an individuals joints to turn into swollen, stiff, and painful.. Aloe vera is a kind of succulent with gel-filled leaves. Making use of pure aloe vera gel to psoriatic pores and skin patches could have a soothing impact, cut back irritation, and enhance hydration. It might even be useful for the remedy of psoriatic arthritis.. Some research recommend aloe vera gel may also help handle particular signs related to psoriasis and psoriatic arthritis. Nonetheless, there may be not a lot proof to assist aloe vera gel as a stand-alone remedy, so an individual with psoriasis ought to speak to their physician about medicated lotions and different cures. ...
Personal blog, from a holistic health coach & doterra wellness advocate, on living with avascular necrosis of the knee, psoriatic arthritis and complex regional pain syndrome.
A natural Arthritis Treatment is something more and more use in order to live with the fitness of Rheumatoid Arthritis. If you are experiencing virtually any pain, due to the added chronic condition of Arthritis, you might find out more pretty natural Treatment options, rather than taking an array of prescription pills early in the day. There is still no way for you to Arthritis and while this really is discouraging many strides are almost always made in treating Arthritis. Natural Arthritis Treatment has been making great progress on the topic of relieving the Symptoms associated with Arthritis. If you do a significant internet search youll amazed at the natural Treatment options available, and you may want to begin for additional info on natural ingredients and how to help you. One of this major advantages of natural Arthritis Treatment can be the cost. Natural Treatment by about much cheaper then a traditional prescription. If you might find budget, you may take into account you cannot ...
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Rheumatoid Arthritis; Osteoarthritis; Juvenile Arthritis; Other Types of Arthritis; Arthritis Pain; previous joint injury overuse of the joint weak thigh muscles and genetics. Arthritis Due To Excess Levels Of Uric Acid In Blood Joint Medicine Pain Clinic Mayo has served a variety of purposes including topical use for joint or musculoskeletal pain. administering a child care center syllabus.. Basically everything I like to do in focusing on the ACL injury as well as the other knee where I have quite a bit of arthritis. Home , Heel Pain , Stress Fractures. Includes back pain articles and tips for reducing pain. Rheumatoid arthritis can be a difficult disease to parvovirus reactive arthritis treating fingers diagnose infection including rheumatic fever Lyme disease fungal arthritis Fifth disease tuberculosis Other spondyloarthropathies include psoriatic arthritis rheumatoid arthritis and gum disease nursing reactive arthritis ucellar spondylitis enteropathic arthritis and sacroiliitis8. Defining ...
Looking for online definition of distal interphalangeal joints in the Medical Dictionary? distal interphalangeal joints explanation free. What is distal interphalangeal joints? Meaning of distal interphalangeal joints medical term. What does distal interphalangeal joints mean?
This study reviews the literature on the anatomy of the connective tissues surrounding the distal interphalangeal joint and further characterizes the three-dimensional relationships of these structures with ultra-high field magnetic resonance imaging. Ten cadaver fingers, fixed in a solution of 5% agar and 4% formalin, were imaged utilising an ultrashield 16.4 Tesla ultra-high field magnetic resonance imaging, yielding a total of 4000 images. Images were analysed using Osirix™ (version 5.5.1 32 bit edition) for three-dimensional reconstruction. We found numerous conflicting descriptions of the connective tissue structures around the distal interphalangeal joint. Based upon our literature review and imaging studies we have defined precisely Clelands ligaments, the oblique proximal septum, Graysons ligaments, the dorsal plate, and the interosseous ligaments of the distal interphalangeal joint ...
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Psoriatic arthritis[edit]. In psoriatic arthritis (PsA), inhibitors of TNF, such as infliximab, improve the signs and symptoms ... It was approved for treating ankylosing spondylitis,[12] psoriatic arthritis, psoriasis, rheumatoid arthritis.[13] ... This includes Crohn's disease, ulcerative colitis, rheumatoid arthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis ... psoriatic arthritis, and ankylosing spondylitis.[12] Only its use in rheumatoid arthritis requires the concomitant use of ...
Osteoclasts are prominent in the tissue destruction found in psoriatic arthritis and rheumatology disorders. The human body is ... Mensah, Kofi A.; Schwarz, Edward M.; Ritchlin, Christopher T. (2008-08-01). "Altered Bone Remodeling in Psoriatic Arthritis". ...
A higher frequency of HLA-B38 was noted psoriatic arthritis patients with erythroderma. Psoriatic arthritis is linked to MICA ... Eastmond CJ (May 1994). "Psoriatic arthritis. Genetics and HLA antigens". Baillière's Clinical Rheumatology. 8 (2): 263-76. doi ... Genetics in patients with psoriatic arthritis]". Orv Hetil (in Hungarian). 147 (50): 2415-9. PMID 17274187. ...
Sep 2011). "Confirmation of TNIP1 and IL23A as susceptibility loci for psoriatic arthritis". Annals of the Rheumatic Diseases. ... Psoriatic arthritis; Systemic Lupus Erythematosus TNIP1 has been shown to interact with TNFAIP3 and MAPK1. GRCh38: Ensembl ...
"Arthritis, Psoriatic , University of Michigan Health System". www.uofmhealth.org. Retrieved 2016-04-13. Mourembou, Gaël; ...
Psoriatic arthritis. The Psoriatic Arthritis Quality of Life (PsAQoL) measures the effect that psoriatic arthritis has on a ... Rheumatoid arthritis.The Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire determines the effect rheumatoid arthritis ... "Comparison of the Psoriatic Arthritis Quality of Life (PsAQoL) questionnaire, the functional status (HAQ) and utility (EQ-5D) ... measures in psoriatic arthritis: Results from a cross-sectional survey". Scandinavian Journal of Rheumatology. 39 (4): 303-9. ...
An association with spondylarthropathies and psoriatic arthritis was observed in several studies. Psoriatic arthritis appears ... Gladman DD, Farewell VT (June 1995). "The role of HLA antigens as indicators of disease progression in psoriatic arthritis. ... Eastmond CJ (May 1994). "Psoriatic arthritis. Genetics and HLA antigens". Baillière's Clinical Rheumatology. 8 (2): 263-76. doi ... or HLA-DRB1 is associated with susceptibility to psoriatic arthritis". J. Rheumatol. 29 (5): 973-8. PMID 12022360. Yuki N, Sato ...
As of March 2014 apremilast has been approved for psoriatic arthritis. In September 2014, the U.S. FDA approved apremilast for ... "FDA approves Otezla to treat psoriatic arthritis". fda.gov. Retrieved 13 June 2014. Muller, George W.; Corral, Laura G.; Shire ... Schafer, Peter (1 June 2012). "Apremilast mechanism of action and application to psoriasis and psoriatic arthritis". ... As of September 2012 apremilast is in phase III trials for psoriasis and phase II trials for rheumatoid arthritis. Efficacy in ...
It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque ... juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other ... Moderate to Severe Rheumatoid Arthritis (RA) (Nov 1998)[7]. *Moderate to Severe Polyarticular Juvenile Rheumatoid Arthritis ( ... "Approval of Etanercept for treatment of psoriatic arthritis". Letter to Sally Gould. Food and Drug Administration. Retrieved ...
It is associated with HLA B27 arthropathies like ankylosing spondylitis, psoriatic arthritis, and reactive arthritis.[3][4] ... Sagittal magnetic resonance images of ankle region: psoriatic arthritis. (a) Short tau inversion recovery (STIR) image, showing ... Schmitt, SK (June 2017). "Reactive Arthritis". Infectious Disease Clinics of North America (Review). 31 (2): 265-77. doi: ...
This includes psoriatic arthritis when it affects the skin.[3] It was also approved to treat Crohn's disease in September 2016 ... Three studies were focused on patients with psoriasis, one on psoriatic arthritis, and one on multiple sclerosis. ... the FDA approved the use of ustekinumab for the treatment of psoriatic arthritis. ... At twelve weeks, psoriatic plaques were reduced by at least three-quarters in 68% of the low-dose ustekinumab group and 74% of ...
He suffers from psoriatic arthritis. He joined the BBC in 1985 as a staff reporter for BBC Radio Leicester before moving to ... Julian Worricker (2016-06-22). "Diagnosed with arthritis in your 30s". BBC News. Worricker to take break from broadcasting ...
"Diagnosis and management of psoriatic arthritis". Drugs. 62 (17): 2447-57. doi:10.2165/00003495-200262170-00004. PMID 12421102 ...
IL17A is upregulated in serum of people with psoriasis and in the synovial fluid of people with psoriatic arthritis, and ... It is used to treat psoriasis, ankylosing spondylitis, and psoriatic arthritis. It is given by subcutaneous injection and is ... In January 2016, the FDA approved it to treat adults with ankylosing spondylitis, and psoriatic arthritis. "Cosentyx 150 mg ... Shirley, M; Scott, LJ (July 2016). "Secukinumab: A Review in Psoriatic Arthritis". Drugs. 76 (11): 1135-45. doi:10.1007/s40265- ...
As of 2008, adalimumab had been approved by the FDA for the treatment of rheumatoid arthritis, psoriatic arthritis, ankylosing ... Adalimumab, sold under the trade name Humira among others, is a medication used to treat rheumatoid arthritis, psoriatic ... In 2003, adalimumab began undergoing trials for use in treating psoriasis and psoriatic arthritis. Adalimumab has been shown to ... 2005: Launched Humira for psoriatic arthritis. Exceeded $1 billion in annual sales for the first time. 2005, 10 December: Eisai ...
Towards international guidelines for the management of psoriatic arthritis.. „J Rheumatol". 33 (7), s. 1228-30, Jul 2006. PMID ... Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: A randomized, controlled trial, „Arthritis ... Information for the Arthritis Advisory Committee. REMICADE® (infliximab). Efficacy and Safety Review. 04 March 2003 ... versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial, „The Lancet ...
Brooks, M (21 March 2014). "FDA Clears Apremilast (Otezla) for Psoriatic Arthritis". Medscape Medical News. WebMD. Retrieved 28 ... FDA in March 2014 for use as a treatment for psoriatic arthritis, and in September 2014 for the treatment of plaque psoriasis ... asthma and rheumatoid arthritis. PDE4D inhibition, along with PDE4A inhibition also appears to be responsible for the ...
Psoriatic arthritis is also a collagen vascular disease. Scurvy - caused by a dietary deficiency in vitamin C, leading to ... Rheumatoid arthritis - Rheumatoid arthritis is a systemic disorder in which immune cells attack and inflame the membrane around ... It can occur alone or with rheumatoid arthritis, scleroderma, or systemic lupus erythematosus. Nine out of 10 cases occur in ... Of the estimated 2.1 million Americans with rheumatoid arthritis, approximately 1.5 million (71 percent) are women. Scleroderma ...
Psoriatic Arthritis Joint Activity Index (PsAJAI), Disease Activity in Psoriatic Arthritis (DAPSA), and Composite Psoriatic ... Patient Global for Psoriatic Arthritis, Dermatology Life Quality Index (DLQI), Psoriatic Arthritis Quality of Life (PsAQOL), ... Psoriatic arthritis is a form of chronic inflammatory arthritis that has a highly variable clinical presentation and frequently ... Psoriatic arthritis affects up to 30 percent of individuals with psoriasis. Psoriasis vulgaris (also known as chronic ...
... and ixekizumab and brodalumab for psoriasis or psoriatic arthritis. Academy of Managed Care Pharmacy, an older US organisation ...
This includes psoriatic arthritis when it affects the skin. It was also approved to treat Crohn's disease in September, 2016. ... Three studies were focused on patients with psoriasis, one on psoriatic arthritis, and one on multiple sclerosis. On December 4 ... On September 24, 2013, the FDA approved the use of ustekinumab for the treatment of psoriatic arthritis. On December 12, 2008 ... At twelve weeks, psoriatic plaques were reduced by at least three-quarters in 68% of the low-dose ustekinumab group and 74% of ...
Robbins developed psoriatic arthritis, which prevented serious climbing. He took up adventure kayaking instead, completing ...
Diagnosis and management of psoriasis and psoriatic arthritis in adults. A national clinical guideline. Edinburgh (Scotland): ... An Italian shared dermatological and rheumatological proposal for the use of biological agents in psoriatic disease. J Eur Acad ...
... rheumatoid arthritis, psoriatic nails,[1] antiphospholipid syndrome,[2]:659 haematological malignancy, and trauma.[3] At first ... subacute infective endocarditis, scleroderma, trichinosis, systemic lupus erythematosus (SLE), rheumatoid arthritis, psoriatic ...
Reactive arthritis, rheumatoid arthritis, and psoriatic arthritis are other possible causes. Treatment of condylar resorption ...
It also used to treat psoriatic arthritis and juvenile idiopathic arthritis. Abatacept has not been tested in pregnant women ... Abatacept is used to treat adults with moderate to severe rheumatoid arthritis (RA) as a second line agent, and as a first line ... Abatacept was developed by Bristol-Myers Squibb and is licensed in the United States for the treatment of rheumatoid arthritis ... Abatacept (marketed as Orencia) is a drug used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the ...
... systemic sclerosis juvenile idiopathic arthritis, and psoriatic arthritis.[12][clarification needed] ... Thus, in rheumatoid arthritis there are autoantibodies to IgG Fc but apparently no corresponding T cell response. In systemic ... Systemic autoimmune diseases include SLE, Sjögren's syndrome, sarcoidosis, scleroderma, rheumatoid arthritis, cryoglobulinemic ... Cigarette smoking is now established as a major risk factor for both incidence and severity of rheumatoid arthritis. This may ...
Its use for the treatment of psoriatic arthritis is being explored. Guselkumab is provided as a subcutaneous injection of 100 ...
Make research projects and school reports about Juvenile arthritis easy with credible articles from our FREE, online ... and pictures about Juvenile arthritis at Encyclopedia.com. ... Psoriatic JA: This type of arthritis usually shows up in fewer ... Juvenile Arthritis. Definition. Juvenile arthritis (JA), also called juvenile rheumatoid arthritis (JRA), refers to a number of ... "Types of Juvenile Arthritis." Arthritis Foundation, 2004. Available online at ,www.arthritis.org/conditions/DiseaseCenter/ ...
Juvenile arthritis is a general name for many types of arthritis that occur in children. Learn more from Boston Childrens ... Psoriatic Arthritis: inflammation of the joints that occurs in some children with psoriasis (a skin condition) ... What is juvenile arthritis?. Juvenile arthritis isnt one condition, but is the general name for many types of arthritis that ... Septic arthritis: arthritis caused by an infection of the joint *Lupus: a chronic autoimmune condition that can have arthritis ...
This could be the first sign that your child has juvenile arthritis. ... 2. Psoriatic Arthritis. *Affects boys and girls equally. Children may develop either arthritis or psoriasis first. ... All About Juvenile Arthritis. Juvenile arthritis is categorized as an idiopathic autoimmune disease. ... 1. Systemic arthritis (Stills disease) *Affects boys and girls equally. Stills disease affects the entire body and often ...
Pain, swelling, or stiffness in one or more joints is commonly present in psoriatic arthritis.[4] Psoriatic arthritis is ... There is no definitive test to diagnose psoriatic arthritis. Symptoms of psoriatic arthritis may closely resemble other ... "Psoriatic Arthritis". Arthritis Action. Retrieved 12 August 2015.. *^ Davidson, Stanley, Davidsons principles and practice of ... and inflammatory bowel disease-associated arthritis.[3] In contrast to psoriatic arthritis, rheumatoid arthritis tends to ...
Find out about psoriatic arthritis, including the symptoms and when to get medical advice. Also, information about causes, ... Symptoms of psoriatic arthritis. Psoriatic arthritis can cause pain, swelling and stiffness in any joint in the body, but it ... Causes of psoriatic arthritis. Almost 1 in 3 people with psoriasis also have psoriatic arthritis. ... Psoriatic arthritis is a type of arthritis that affects some people with the skin condition psoriasis. It typically causes ...
... and prescription medicines for psoriatic arthritis. Some treat symptoms of both psoriasis and psoriatic arthritis, others ... Home > About Arthritis > Types > Psoriatic Arthritis > Treatment. Psoriatic Arthritis Treatment. There are several over-the- ... More About Psoriatic Arthritis. FDA OKs Biologic for Psoriatic Arthritis. The U.S. Food and Drug Administration (FDA) has ... More About Psoriatic Arthritis. FDA OKs Biologic for Psoriatic Arthritis. The U.S. Food and Drug Administration (FDA) has ...
Psoriatic Arthritis (National Institute of Arthritis and Musculoskeletal and Skin Diseases) * Psoriatic Arthritis (American ... Article: Psoriatic arthritis: still room for improvement. * Article: Targeting p19 in psoriatic arthritis: more than just ... The primary NIH organization for research on Psoriatic Arthritis is the National Institute of Arthritis and Musculoskeletal and ... Psoriasis/Psoriatic Arthritis and Pregnancy (Organization of Teratology Information Specialists) - PDF - In English and Spanish ...
symmetric psoriatic arthritis can be disabling, causing varying degrees of ... symmetric psoriatic arthritis affects the same joints -- usually in multiple matching pairs -- on opposite sides of the body. ... What is symmetric psoriatic arthritis?. ANSWER Symmetric psoriatic arthritis affects the same joints -- usually in multiple ... More Answers On Psoriatic Arthritis. *What is distal interphalangeal predominant (DIP) psoriatic arthritis? ...
WebMD provides comprehensive medical information on psoriatic arthritis including symptoms, causes, and treatments. Learn more ... What is a common side effect of psoriatic arthritis?. *How are swollen joints a sign of ineffective psoriatic arthritis ... How can you get psoriatic arthritis from psoriasis?. *Should I relax before bedtime to avoid psoriatic arthritis-related ... Where can you get nonsteroidal anti-inflammatory drugs for psoriatic arthritis?. *How can a healthy diet help with psoriatic ...
... arthritis) that often occurs with a skin condition called psoriasis. ... Some people with psoriatic arthritis may have inflammation of the eyes.. Most of the time, people with psoriatic arthritis have ... Psoriatic arthritis is a joint problem (arthritis) that often occurs with a skin condition called psoriasis. ... In most cases, psoriasis comes before the arthritis.. The cause of psoriatic arthritis is not known. Genes, immune system, and ...
Get more information on the causes, symptoms, diagnosis, and medications for psoriatic arthritis. ... What Is Psoriatic Arthritis?. Psoriatic arthritis is a type of arthritis (inflammation of the joints) accompanied by ... What Causes Psoriatic Arthritis?. The exact cause of psoriatic arthritis is unknown, but it is believed to involve genetics, ... How Is Psoriatic Arthritis Diagnosed?. There is not one definitive test to diagnose psoriatic arthritis. It is usually ...
Psoriatic arthritis (PsA) is a relapsing inflammatory joint condition associated with psoriasis that affects about 1-3% of the ... Psoriatic Arthritis Types. News-Medical. 03 April 2020. ,https://www.news-medical.net/health/Psoriatic-Arthritis-Types.aspx,. ... Psoriatic Arthritis Types. News-Medical, viewed 03 April 2020, https://www.news-medical.net/health/Psoriatic-Arthritis-Types. ... Psoriatic Arthritis Types. News-Medical. https://www.news-medical.net/health/Psoriatic-Arthritis-Types.aspx. (accessed April ...
Alternative Therapies for Psoriatic Arthritis Julie Cerrone Croner takes a holistic approach to managing her psoriatic ... When you have psoriatic arthritis, you may experience hand pain, stiffness, tingling, and swelling. Adding these hand exercises ... 10 Strategies for Staying Active With Psoriasis and Psoriatic Arthritis Exercise is important for anyone with a chronic illness ... Psoriatic Disease: Help Others Help You 10 tips to get the support you need with your chronic condition. ...
Get the Sleep You Need With Psoriatic Arthritis If you have psoriatic arthritis, chances are good that you also have trouble ... Make Cooking Easier When You Have Psoriatic Arthritis You dont have to give up cooking with psoriatic arthritis. Here are ... 11 Ways to Keep Your Feet Happy and Healthy with Psoriatic Arthritis Your feet take a beating over the course of a day. Heres ... Psoriatic Arthritis can affect your feet, eyes, joints, and more over your lifetime. Get to know the many specialists who can ...
... and clinical studies on arthritis and rheumatic diseases. The journal is aimed at both researchers and clinicians, covering ... Arthritis is a peer-reviewed, Open Access journal that publishes original research articles, review articles, ... "Guidelines of care for the management of psoriasis and psoriatic arthritis: section 2. psoriatic arthritis: overview and ... Psoriatic arthritis is an inflammatory arthritis with a number of clinical patterns. Currently there are no validated screening ...
She writes a blog about "a day in the life of a city girl living with psoriatic arthritis" at www.CityGirlFlare.com. ... Fatigue is one of the most common symptoms of psoriatic arthritis. Learn more about this connection and easy ways to boost your ... How Your Energy Levels Are Connected to Psoriatic Arthritis. Medically reviewed by Debra Sullivan, PhD, MSN, CNE, COI. ... Living with an "invisible illness" like psoriatic arthritis (PsA) is tough. Despite the worlds best efforts to be kinder and ...
Outcomes after hip replacement surgery are as good in patients with psoriatic arthritis or cutaneous psoriasis as in patients ... Patients with psoriatic arthritis (PsA) or cutaneous psoriasis (PsC) are not at risk for worse outcomes after total hip ... "There were no statistically significant differences in age, race, or education between THA patients with psoriatic arthritis, ... Fast Five Quiz: Can You Identify Psoriatic Arthritis and Initiate the Best Treatment Practices? ...
Learn how to work with your doctor to treat your psoriatic arthritis with medication to get it under control and keep it that ... Psoriatic Arthritis. Psoriatic Arthritis and Body Image. Having psoriatic arthritis means having both skin and joint symptoms ... Psoriatic Arthritis. Psoriatic Arthritis: Better Living Toolkit. Learn more about how to manage psoriatic arthritis with ... Diagnosed With Psoriatic Arthritis?. Get the latest news and tips about living with Psoriatic Arthritis in the Living Your Yes ...
Psoriatic arthritis is a distinct form of inflammatory arthritis associated with psoriasis, which exists in a number of ... deforming and disabling arthritis. The prognostic factors for the development of this type of arthritis are unclear as yet. ... Although a large number of patients have a mild form of arthritis, there is a population who present with a very aggressive, ... and the approach to its management should be similar to that for rheumatoid arthritis. Current investigations are in progress ...
... and rheumatoid arthritis (RA) are inflammatory joint conditions with a wide variability of clinical features, and both may ... Psoriatic Arthritis vs Rheumatoid Arthritis. News-Medical. https://www.news-medical.net/health/Psoriatic-Arthritis-vs- ... Both psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are inflammatory joint conditions with a wide variability of ... Psoriatic Arthritis vs Rheumatoid Arthritis. News-Medical, viewed 16 June 2019, https://www.news-medical.net/health/Psoriatic- ...
Psoriatic arthritis is an autoimmune condition in which your body attacks your healthy joints and causes inflammation. Learn ... The anemia associated with psoriatic arthritis is most often mild. If you have other symptoms of psoriatic arthritis, your ... Although psoriatic arthritis (PsA) and rheumatoid arthritis (RA) both begin in the immune system, the two conditions are very ... Psoriatic Arthritis vs. Rheumatoid Arthritis: Learn the Differences. Medically reviewed by Steve Kim, MD. ...
Here, learn more about how psoriatic arthritis affects the spine. ... Psoriatic arthritis can cause stiffness and pain in the spinal ... Symptoms of psoriatic arthritis in the spine. Share on Pinterest. Symptoms of psoriatic arthritis in the spine can include pain ... Axial arthritis occurs in up to 50 percent of people with psoriatic arthritis. If this type of arthritis affects the spine, it ... What is juvenile psoriatic arthritis?. When psoriatic arthritis occurs in children or adolescents, doctors classify it as ...
Psoriatic arthritis (PsA) can contribute to some mental health conditions, including depression. In this article, we look at ... More in Finding the Path With Psoriatic Arthritis. *. What do the symptoms of psoriatic arthritis look like? ... psoriatic arthritis can affect a persons mental health. People with psoriatic arthritis are more likely to experience ... Psoriatic arthritis and depression: The link. Medically reviewed by Nancy Carteron, M.D., FACR - Written by Charlotte Lillis on ...
Ixekizumab significantly improves symptoms of psoriatic arthritis in patients naive to prior biologic therapy and in patients ... The US Food and Drug Administration has approved ixekizumab (Taltz, Eli Lilly) to treat adults with active psoriatic arthritis ... Cite this: Ixekizumab Gets FDA Nod for Active Psoriatic Arthritis - Medscape - Dec 06, 2017. ...
Psoriatic arthritis occurs in people who have a skin condition called psoriasis. Some people develop severe joint damage from ... Psoriatic arthritis. Rochester, Minn.: Mayo Foundation for Medical Education and Research; 2014. ... National Institute of Arthritis and Musculoskeletal and Skin Diseases. http://www.niams.nih.gov/health_info/psoriatic_arthritis ... Psoriatic arthritis. In: Kelleys Textbook of Rheumatology. 9th ed. Philadelphia, Pa.: Saunders Elsevier; 2013. http://www. ...
  • If you think you have signs of psoriatic arthritis, or if you just want to learn more about the disease, make an appointment with your dermatologist. (psoriasis.org)
  • This CME/CE/CPE program is intended for dermatologists, rheumatologists, internal medicine/family practice/primary care physicians, nurse practitioners, nurses, pharmacists, physician assistants, and other clinicians who interact with and/or treat patients with psoriasis and psoriatic arthritis. (merlot.org)
  • Psoriatic arthritis may be present with or without obvious skin lesions, with minimal skin involvement (eg, scalp, umbilicus, intergluteal cleft), or with only nail malformations. (medscape.com)
  • Some researchers think that the arthritis may be an immune system response to bacteria from the skin lesions. (eorthopod.com)
  • Professor Neil McHugh is leading a £2 million project into improving the lives of those with the painful arthritic condition Psoriatic Arthritis (PsA). (bath.ac.uk)