Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.ArthritisArthritis, Experimental: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.Arthritis, Infectious: Arthritis caused by BACTERIA; RICKETTSIA; MYCOPLASMA; VIRUSES; FUNGI; or PARASITES.Arthritis, Juvenile: Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.Arthritis, Psoriatic: A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.Arthritis, Reactive: An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.Synovial Membrane: The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.Joints: Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.Synovial Fluid: The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.Arthritis, Gouty: Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.Rheumatoid Factor: Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.Mice, Inbred DBASynovitis: Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)Osteoarthritis: A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.Collagen Type II: A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.Methotrexate: An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Rats, Inbred LewAutoantibodies: Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.Blood Sedimentation: Measurement of rate of settling of erythrocytes in anticoagulated blood.Injections, Intra-Articular: Methods of delivering drugs into a joint space.Tumor Necrosis Factor-alpha: Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.Rheumatic Diseases: Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.Immunoglobulin G: The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.Arthrography: Roentgenography of a joint, usually after injection of either positive or negative contrast medium.Rheumatology: A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.Knee Joint: A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.Metacarpophalangeal Joint: The articulation between a metacarpal bone and a phalanx.Spondylitis, Ankylosing: A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.Sulfasalazine: A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)Peptides, Cyclic: Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).Autoimmune Diseases: Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.Antibodies, Monoclonal: Antibodies produced by a single clone of cells.Gold Sodium Thiomalate: A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.Wrist Joint: The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).Rheumatoid Nodule: Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.Collagen: A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).HLA-DRB1 Chains: A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.Finger Joint: The articulation between the head of one phalanx and the base of the one distal to it, in each finger.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Tarsal Joints: The articulations between the various TARSAL BONES. This does not include the ANKLE JOINT which consists of the articulations between the TIBIA; FIBULA; and TALUS.Lyme Disease: An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.Receptors, Tumor Necrosis Factor: Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.HLA-DR4 Antigen: An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.Anti-Inflammatory Agents: Substances that reduce or suppress INFLAMMATION.Joint DiseasesHLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.CitrullineCytokines: Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.Spondylarthropathies: Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.Foot Joints: The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.Psoriasis: A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.Cartilage, Articular: A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.Ankle Joint: The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.Inflammation: A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.T-Lymphocytes: Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.Interleukin-17: A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.Edema: Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.Freund's Adjuvant: An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.Tarsus, Animal: The region in the hindlimb of a quadruped, corresponding to the human ANKLE.Enzyme-Linked Immunosorbent Assay: An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.Tenosynovitis: Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.HLA-B27 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Organogold Compounds: Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.Drug Therapy, Combination: Therapy with two or more separate preparations given for a combined effect.Hand Joints: The articulations extending from the WRIST distally to the FINGERS. These include the WRIST JOINT; CARPAL JOINTS; METACARPOPHALANGEAL JOINT; and FINGER JOINT.Glucose-6-Phosphate Isomerase: An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.Disability Evaluation: Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.Pain: An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.Lupus Erythematosus, Systemic: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Interleukin-6: A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.Chronic Disease: Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)Interleukin-1: A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Interleukin 1 Receptor Antagonist Protein: A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.Cartilage: A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.National Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. It supports research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress. It was established in 1986.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Mice, Inbred C57BLCase-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.Autoantigens: Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.Prednisolone: A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.Penicillamine: 3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.Borrelia burgdorferi: A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.Immunoglobulin M: A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.Hindlimb: Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)Yersinia Infections: Infections with bacteria of the genus YERSINIA.Arthralgia: Pain in the joint.Spondylarthritis: Inflammation of the joints of the SPINE, the intervertebral articulations.Autoimmunity: Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.Pain Measurement: Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.Toe Joint: The articulation between the head of one phalanx and the base of the one distal to it, in each toe.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Fibroblasts: Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.Osteoclasts: A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.Glucocorticoids: A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.Antibodies, Antinuclear: Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.Antigen-Antibody Complex: The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.C-Reactive Protein: A plasma protein that circulates in increased amounts during inflammation and after tissue damage.Hand Deformities, Acquired: Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Antibodies, Monoclonal, Humanized: Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.Lymphocyte Activation: Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.Antibodies: Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Cohort Studies: Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.Bone Resorption: Bone loss due to osteoclastic activity.Matrix Metalloproteinase 3: An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)Interleukin-1beta: An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Felty Syndrome: A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.Foot: The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.Double-Blind Method: A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.Hand: The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.B-Lymphocytes: Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.Sternoclavicular Joint: A double gliding joint formed by the CLAVICLE, superior and lateral parts of the manubrium sterni at the clavicular notch, and the cartilage of the first rib.Inflammation Mediators: The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).Metatarsophalangeal Joint: The articulation between a metatarsal bone (METATARSAL BONES) and a phalanx.Auranofin: An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.Sjogren's Syndrome: Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.Macrophages: The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Protein Tyrosine Phosphatase, Non-Receptor Type 22: A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.Gout: Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Spondylitis: Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.Osteitis: Inflammation of the bone.Mice, Inbred BALB CArthritis-Encephalitis Virus, Caprine: A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), closely related to VISNA-MAEDI VIRUS and causing acute encephalomyelitis; chronic arthritis; PNEUMONIA; MASTITIS; and GLOMERULONEPHRITIS in goats. It is transmitted mainly in the colostrum and milk.Biological Therapy: Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.Biological Products: Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.Statistics, Nonparametric: A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)RANK Ligand: A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.Health Status: The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.Epitopes: Sites on an antigen that interact with specific antibodies.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Neutrophils: Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Early Diagnosis: Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Th17 Cells: Subset of helper-effector T-lymphocytes which synthesize and secrete IL-17, IL-17F, and IL-22. These cytokines are involved in host defenses and tissue inflammation in autoimmune diseases.Activities of Daily Living: The performance of the basic activities of self care, such as dressing, ambulation, or eating.Aurothioglucose: A thioglucose derivative used as an antirheumatic and experimentally to produce obesity in animals.Bone Diseases: Diseases of BONES.Disease Susceptibility: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.Borrelia burgdorferi Group: Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.Sialoglycoproteins: Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Spleen: An encapsulated lymphatic organ through which venous blood filters.Arthrodesis: The surgical fixation of a joint by a procedure designed to accomplish fusion of the joint surfaces by promoting the proliferation of bone cells. (Dorland, 28th ed)Range of Motion, Articular: The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.Arthroplasty, Replacement: Partial or total replacement of a joint.CD4-Positive T-Lymphocytes: A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.Immunologic Factors: Biologically active substances whose activities affect or play a role in the functioning of the immune system.Immunoconjugates: Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.Joint Prosthesis: Prostheses used to partially or totally replace a human or animal joint. (from UMDNS, 1999)Monocytes: Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Stifle: In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.Arthroplasty: Surgical reconstruction of a joint to relieve pain or restore motion.Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)Tuberculosis, Osteoarticular: Tuberculosis of the bones or joints.Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Foot Deformities, Acquired: Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.Antibody Formation: The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.Elbow Joint: A hinge joint connecting the FOREARM to the ARM.Interleukin-10: A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.Prevalence: The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.Receptors, IgG: Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).Serum Albumin, Bovine: Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)Atlanto-Axial Joint: The joint involving the CERVICAL ATLAS and axis bones.Matrilin Proteins: PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.Hip Joint: The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.Antibodies, Anti-Idiotypic: Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.Age of Onset: The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Arthroscopy: Endoscopic examination, therapy and surgery of the joint.Chondrocalcinosis: Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)Matrix Metalloproteinases: A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.Connective Tissue Diseases: A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.Leukocytes, Mononuclear: Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.Sacroiliac Joint: The immovable joint formed by the lateral surfaces of the SACRUM and ILIUM.Hand Bones: The CARPAL BONES; METACARPAL BONES; and FINGER PHALANGES. In each hand there are eight carpal bones, five metacarpal bones, and 14 phalanges.Terpenes: A class of compounds composed of repeating 5-carbon units of HEMITERPENES.Aggrecans: Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Bursa, Synovial: A fluid-filled sac lined with SYNOVIAL MEMBRANE that provides a cushion between bones, tendons and/or muscles around a joint.

Association of the inflammatory state in active juvenile rheumatoid arthritis with hypo-high-density lipoproteinemia and reduced lipoprotein-associated platelet-activating factor acetylhydrolase activity. (1/962)

OBJECTIVE: To investigate the relationship between the quantitative and qualitative abnormalities of apolipoprotein B (Apo B)- and Apo A-I-containing lipoproteins and between lipoprotein-associated platelet-activating factor acetylhydrolase (PAF-AH) activity in patients with juvenile rheumatoid arthritis (JRA) as a function of the inflammatory state. METHODS: Twenty-six JRA patients and 22 age- and sex-matched control subjects with normal lipid levels participated in the study. Fourteen patients had active disease, and 12 had inactive disease. Plasma lipoproteins were fractionated by gradient ultracentrifugation into 9 subfractions, and their chemical composition and mass were determined. The PAF-AH activity associated with lipoprotein subfractions and the activity in plasma were also measured. RESULTS: Patients with active JRA had significantly lower plasma total cholesterol and high-density lipoprotein (HDL) cholesterol levels as compared with controls, due to the decrease in the mass of both the HDL2 and HDL3 subfractions. Patients with active JRA also had higher plasma triglyceride levels, mainly due to the higher triglyceride content of the very low-density lipoprotein plus the intermediate-density lipoprotein subfraction. The plasma PAF-AH activity in patients with active JRA was lower than that in controls, mainly due to the decrease in PAF-AH activity associated with the intermediate and dense low-density lipoprotein subclasses. The lipid abnormalities and the reduction in plasma PAF-AH activity were significantly correlated with plasma C-reactive protein levels and were not observed in patients with inactive JRA. CONCLUSION: This is the first study to show that patients with active JRA exhibit low levels of HDL2 and HDL3 and are deficient in plasma PAF-AH activity. These alterations suggest that active JRA is associated with partial loss of the antiinflammatory activity of plasma Apo B- and Apo A-I-containing lipoproteins.  (+info)

Modular variations of the human major histocompatibility complex class III genes for serine/threonine kinase RP, complement component C4, steroid 21-hydroxylase CYP21, and tenascin TNX (the RCCX module). A mechanism for gene deletions and disease associations. (2/962)

The frequent variations of human complement component C4 gene size and gene numbers, plus the extensive polymorphism of the proteins, render C4 an excellent marker for major histocompatibility complex disease associations. As shown by definitive RFLPs, the tandemly arranged genes RP, C4, CYP21, and TNX are duplicated together as a discrete genetic unit termed the RCCX module. Duplications of the RCCX modules occurred by the addition of genomic fragments containing a long (L) or a short (S) C4 gene, a CYP21A or a CYP21B gene, and the gene fragments TNXA and RP2. Four major RCCX structures with bimodular L-L, bimodular L-S, monomodular L, and monomodular S are present in the Caucasian population. These modules are readily detectable by TaqI RFLPs. The RCCX modular variations appear to be a root cause for the acquisition of deleterious mutations from pseudogenes or gene segments in the RCCX to their corresponding functional genes. In a patient with congenital adrenal hyperplasia, we discovered a TNXB-TNXA recombinant with the deletion of RP2-C4B-CYP21B. Elucidation of the DNA sequence for the recombination breakpoint region and sequence analyses yielded definitive proof for an unequal crossover between TNXA from a bimodular chromosome and TNXB from a monomodular chromosome.  (+info)

Assessment of bone mineral density in adults with a history of juvenile chronic arthritis: a cross-sectional long-term followup study. (3/962)

OBJECTIVE: To assess bone mineral density (BMD) and bone turnover in adults with a history of juvenile chronic arthritis (JCA) or persistent JCA, and to identify predictors of reduced BMD. METHODS: Sixty-five white patients (mean age 32.2 years) with a history of JCA and 65 age-, sex-, height-, and weight-matched healthy control subjects participated in the study. Densitometry of the left hip and the lumbar spine was performed, and osteocalcin (bone formation marker) and crosslinks (bone resorption marker) were measured. In addition, bone-related clinical parameters were assessed in the JCA group. RESULTS: BMD in the hip and lumbar spine was significantly lower in the JCA group than in the controls. Levels of osteocalcin and crosslinks were significantly increased in the JCA group. According to WHO definitions, significantly more subjects in the JCA group had "osteopenia" and "osteoporosis" than would be expected in a normal population sample. Active disease at the time of the study (1996-1997), baseline erosions evaluated in 1979, Steinbrocker functional class in 1996-1997, polyarticular course of JCA, and history of systemic steroid treatment for more than 1 year were significantly associated with reduced BMD. In linear regression analysis including both the JCA and control groups, presence of JCA proved to be the factor most strongly associated with reduced BMD, explaining approximately 20% of its variation. CONCLUSION: Reduced BMD and evidence of increased bone turnover suggest that JCA patients may be at risk of developing premature osteoporosis and associated fractures later in life. The data are consistent with the concept that BMD in JCA is determined by many factors.  (+info)

Molecular fingerprinting reveals non-overlapping T cell oligoclonality between an inflamed site and peripheral blood. (4/962)

We have demonstrated a stable expansion of CD8+ T cells in the peripheral blood of a child with chronic arthritis. The expanded TCRBV family (TCRBV14) was enriched for CD57hiCD28- T cells. Sequencing of the TCRBV14 amplification products showed a TCR sequence which contributed 32% of the total TCR in the CD8+TCRBV14 population. Using the modified heteroduplex technique, the CD8+TCRBV14 cells showed a clonal pattern and these bands were restricted to the CD28- population. This method also detected multiple other clones within the CD8+ population but few in the CD4+ cells. The dominant TCRBV14+ clone was not detectable in synovial fluid T cells from two inflamed joints by CDR3 length analysis or heteroduplex probing, suggesting that this long-lived clone is excluded from inflammatory sites. Synovial fluid T cells showed an unexpected discordance of the CD28 and CD57 phenotype compared to peripheral blood mononuclear cells. T cells from both inflamed joints both showed marked oligoclonality in all TCR families and had almost identical heteroduplex patterns. Taken together these data suggest that some clones are actively excluded from inflamed sites in juvenile chronic arthritis, yet the pattern of restricted T cell expansion is shared between sites of inflammation.  (+info)

Absence of association between interleukin 1 alpha and oligoarticular juvenile chronic arthritis in UK patients. (5/962)

OBJECTIVE: To determine whether interleukin 1 alpha (IL-1alpha) polymorphisms are associated with UK oligoarticular juvenile chronic arthritis (JCA). PATIENTS AND CONTROLS: A well-characterized population of 164 UK Caucasian oligo-JCA patients and a control panel of 173 unrelated healthy UK Caucasian individuals. METHODS: The IL-1alpha promoter mutation at -889 was examined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. The cases and controls were also genotyped for an IL-1alpha intronic microsatellite repeat. RESULTS: No association was observed between IL-1alpha polymorphisms and UK oligoarticular JCA patients. In particular, no association between IL-1alpha polymorphisms and chronic anterior uveitis was found. CONCLUSIONS: IL-1alpha is not associated with oligoarticular JCA in UK patients. This differs markedly to findings for IL-1alpha in Norwegian JCA patients.  (+info)

Responsiveness of outcome measures in juvenile chronic arthritis. Italian Pediatric Rheumatology Study Group. (6/962)

OBJECTIVE: To examine the responsiveness of the disease activity measures more commonly used in juvenile chronic arthritis (JCA) clinical trials. METHODS: Data were obtained from an open-label, non-controlled, multicentre trial designed to investigate the efficacy of methotrexate (MTX) in children with JCA. Outcome measures, including physician and parent global assessments, functional ability measures, articular variables, and laboratory indicators of systemic inflammation, were assessed at baseline and after 6 months of MTX treatment in 132 patients. Responsiveness of endpoint variables was evaluated by assessing the effect size (ES) and the standardized response median (SRM). RESULTS: Physician and parent global assessments were the more responsive instruments, showing ES and SRM above 1.0. Erythrocyte sedimentation rate, C-reactive protein, functional status measures and articular variables showed intermediate responsiveness. Morning stiffness, haemoglobin and platelet count were the least responsive instruments. CONCLUSION: The results of our analysis indicate that subjective estimations of the disease activity, either by the physician or parents, are the most responsive instruments in the assessment of the therapeutic response in children with JCA. The responsiveness of outcome measures in JCA should be further investigated in prospective controlled studies.  (+info)

Assessment of mutilans-like hand deformities in chronic inflammatory joint diseases. A radiographic study of 52 patients. (7/962)

OBJECTIVES: To evaluate patients with mutilans-like hand deformities in chronic inflammatory joint diseases and to determine radiographic scoring systems for arthritis mutilans (AM). METHODS: A total of 52 patients with severe hand deformities were collected during 1997. A Larsen hand score of 0-110 was formed to describe destruction of the hand joints. Secondly, each ray of the hand was assessed individually by summing the Larsen grade of the wrist and the grades of the MCP and PIP joints. When the sum of these grades was > or = 13, the finger was considered to be mutilated. A mutilans hand score of 0-10 was formed according to the number of mutilans fingers. Surgical treatment and spontaneous fusions were recorded. RESULTS: The study consisted of 22 patients with juvenile rheumatoid arthritis (JRA), nine with rheumatoid factor (RF) positive and 13 with RF negative arthritis, 27 patients with RF positive RA, and three adult patients with other diagnoses. The mean age of patients with adult rheumatic diseases was 27 years at the onset of arthritis. The mean disease duration in all patients was 30 years. The mean Larsen hand score was 93. Four patients had no mutilans fingers and in 15 patients all 10 fingers were mutilated. The Larsen hand score of 0-110 and the mutilans hand score of 0-10 correlated well (rs = 0.90). Fourteen patients showed spontaneous fusions in the peripheral joints. A total of 457 operations were performed on 48 patients. CONCLUSION: Both the Larsen hand score of 0-110 and the mutilans hand score of 0-10 improve accuracy in evaluating mutilans-like hand deformities, but in unevenly distributed hand deformities the mutilans hand score is better in describing deformation of individual fingers.  (+info)

Polymorphic haplotypes of the interleukin-10 5' flanking region determine variable interleukin-10 transcription and are associated with particular phenotypes of juvenile rheumatoid arthritis. (8/962)

OBJECTIVE: To determine the distribution of the interleukin-10 (IL-10) 5' flanking region haplotypes in children with arthritis and in controls, and to investigate the functional significance of each haplotype. METHODS: Sequence-specific oligonucleotide probing was used to determine haplotype frequency. Transient transfection studies were used to investigate the transcription of reporter genes driven by each haplotype. Whole blood cultures were performed to assess IL-10 production by each genotype. RESULTS: Patients with arthritis involving >4 joints were more likely to have a genotype with an ATA haplotype than those whose arthritis remained restricted to <4 joints. This ATA haplotype was associated with lower transcriptional activity than the GCC haplotype (P = 0.02), and the ATA/ATA genotype was associated with lower IL-10 production under lipopolysaccharide stimulation than other genotypes (P < 0.02). CONCLUSION: The results of this study demonstrate the functional significance of the ATA haplotype and reveal a significant association of genotypes containing this haplotype with extended oligoarthritis.  (+info)

Hip replacement is often performed in patients with juvenile arthritis when their joints have been severely damaged by the disease. A study at Hospital for Special Surgery (HSS) finds that the procedure is an excellent option to alleviate pain and improve function in juvenile arthritis patients under age 35 when conservative treatments fail to provide relief. The study, to be presented at the American Academy of Orthopaedic Surgeons annual meeting on March 24, found that total hip replacement (THR) lasted at least 10 years in 85 percent of patients, and 20 years in 50 percent of patients. When the implant wears out or is no longer viable, juvenile arthritis patients generally have a revision surgery, or second hip replacement. An estimated 300,000 children in the United States have been diagnosed with juvenile arthritis, technically known as juvenile idiopathic arthritis (JIA) or juvenile rheumatoid arthritis. The disease is diagnosed before age 16 and often persists into adulthood. It ...
Tocilizumab in the treatment of systemic juvenile idiopathic arthritis Miho Murakami,1 Minako Tomiita,2,3 Norihiro Nishimoto11Laboratory of Immune Regulation, Wakayama Medical University, Wakayama, 2Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, 3Department of Allergy and Rheumatology, Chiba Childrens Hospital, Chiba, JapanAbstract: Systemic juvenile idiopathic arthritis is one of the common rheumatic diseases in childhood and characterized by spiking fever, evanescent skin rash, lymphadenopathy, hepatosplenomegaly, and serositis, in addition to arthritis. Children with systemic juvenile idiopathic arthritis often show growth retardation and developmental abnormality, as well as macrophage activation syndrome, a life-threatening complication. Overproduction of interleukin-6 is pathologically responsible for the systemic inflammatory manifestations and abnormal laboratory results with systemic juvenile idiopathic arthritis. Thus, tocilizumab, a humanized antihuman
Juvenile arthritis occurs in children 16 years of age or younger. Children with severe juvenile arthritis may be candidates for glucocorticoid medication, the use of which has been linked to bone loss in children as well as adults. Physical activity can be challenging in children with juvenile arthritis because it may cause pain. Incorporating physical activities recommended by the childs doctor and a diet rich in calcium and vitamin D is especially important, so that these children can build adequate bone mass and reduce the risk of future fracture.. ...
Get information, facts, and pictures about Juvenile arthritis at Encyclopedia.com. Make research projects and school reports about Juvenile arthritis easy with credible articles from our FREE, online encyclopedia and dictionary.
... - Get information about diagnosis and prognosis of Juvenile Arthritis, onlymyhealth.com is providing articles related to Juvenile Arthritis diagnosis and prognosis.
TY - JOUR. T1 - The Ukrainian version of the Juvenile Arthritis Multidimensional Assessment Report (JAMAR). AU - Paediatric Rheumatology International Trials Organisation (PRINTO). AU - Boyko, Yaryna. AU - Hrytsiuk, Ihor. AU - Consolaro, Alessandro. AU - Bovis, Francesca. AU - Ruperto, Nicolino. PY - 2018/4. Y1 - 2018/4. N2 - The Juvenile Arthritis Multidimensional Assessment Report (JAMAR) is a new parent/patient-reported outcome measure that enables a thorough assessment of the disease status in children with juvenile idiopathic arthritis (JIA). We report the results of the cross-cultural adaptation and validation of the parent and patient versions of the JAMAR in the Ukrainian language. The reading comprehension of the questionnaire was tested in 10 JIA parents and patients. Each participating centre was asked to collect demographic, clinical data and the JAMAR in 100 consecutive JIA patients or all consecutive patients seen in a 6-month period and to administer the JAMAR to 100 healthy ...
JA Camps. Our JA camp programs give kids living with juvenile arthritis and other childhood rheumatic diseases the chance to be themselves. Each of our 50 camp programs provides a safe and nurturing environment that is supervised by trained staff and medical professionals. All camps feature traditional summer camping activities, from canoeing and archery to campfires and sing-alongs. In addition to forging new friendships and amazing memories, campers gain a better understanding of their disease while increasing independence and self-confidence.. Family Events. The Arthritis Foundation hosts JA family events throughout the year to help kids and their families live better with JA and other childhood rheumatic disease. These programs are informative and supportive events that deal with various aspects of living with JA, including an overview of the disease, medications, pain management techniques, exercise and more!. National Juvenile Arthritis Conference. The Arthritis Foundations annual ...
Juvenile Arthritis Research (the JAR Project). JAR is a non-profit project supported by donations, researching a cure for JIA and raising awareness that children and young people get arthritis. We do not give individual medical or clinical advice. Juvenile Arthritis Research is a project of the Jabez Charitable Trust (UK charity no. 1091620). This website resource provides information only and should not be used for the treatment of medical conditions. The authors are not responsible or liable, directly or indirectly, for any form of damages whatsoever resulting from the use (or misuse) of information contained in or implied by the information on this site.Read our Privacy notice. You can support our work at give.net.Follow us on social media - Facebook, Twitter and Instagram. ...
From Ethan Berkovitz. My name is Ethan Berkovitz, I am a 16-year-old high school sophomore and my favorite sports are soccer and futsal, a type of indoor soccer with five players per team. I play on the U.S. Youth Futsal 16-and-under National Team, and this summer I got to compete and represent our country in Costa Rica. I have been playing soccer since I was 3 years old - and I have juvenile arthritis.. I didnt always have juvenile arthritis. It all started when I was 8 years old, when I started having pain in my legs, hands and wrists. I thought I was having growing pains, but it got worse and worse in just a few short months. I couldnt even walk down the stairs, or to the bus stop, so my dad had to carry me. Sometimes, I didnt make it to school because I didnt feel very well and I would get fevers, so I felt really sick. I loved playing all kinds of sports back then with my friends and I was on lots of different teams. I also would ride my bike, skateboard, rollerblade and much ...
Each year at this time, we commemorate the estimated 300,000 children and their families in the United States who face the everyday challenges of living with juvenile arthritis (JA) and related diseases. Juvenile arthritis is an umbrella term used to describe the many autoimmune and inflammatory conditions or pediatric rheumatic diseases that can develop in children and teens.. The various types of juvenile arthritis share many common symptoms, like pain, joint swelling, redness and warmth, but each type of JA is distinct and has its own unique characteristics and how it affects the body.. Common Types of Juvenile Arthritis. Juvenile idiopathic arthritis (JIA). Considered the most common form of childhood arthritis, JIA includes six subtypes: oligoarthritis, polyarthritis, systemic, enthesitis-related, juvenile psoriatic arthritis or undifferentiated.. Juvenile dermatomyositis. An inflammatory disease, juvenile dermatomyositis causes muscle weakness and a skin rash on the eyelids and ...
The terms Juvenile Arthritis (JA), Juvenile Rheumatoid Arthritis (JRA), Juvenile Idiopathic Arthritis (JIA) and Juvenile Chronic Arthritis (JCA) are not synonymous; their definitions vary slightly. The terminology used depends largely on when the child was diagnosed and what country the child lived in at the time of diagnosis. Even though a diseases name changes, people…
Background Anakinra pharmacokinetics and pharmacodynamics were investigated in children and adolescents treated for systemic-onset juvenile idiopathic arthritis (SJIA) and autoinflammatory syndromes.
[48 Pages Report] Check for Discount on Polyarticular Juvenile Idiopathic Arthritis (PJIA) - Pipeline Review, H1 2016 report by Global Markets Direct. Global Markets Directs, Polyarticular Juvenile Idiopathic Arthritis (...
Diagnose childrens arthritis from Kasturi Hospitals, known for treatment of all common types of pediatric arthritis. Make an appointment for juvenile arthritis care at affordable rate.
Any child can suffer from juvenile arthritis according to studies approximately one child in every 1,000 in a given year can develop arthritis (but most of them are mild) and about one child in every 10,000 will develop severe arthritis.
Juvenile Arthritis are autoimmune diseases. Kasturi Hospitals, Hyderabad offers cost effective treatment for your kid to enjoy the best time of their life.
Juvenile arthritis is a general name for many types of arthritis that occur in children. Learn more from Boston Childrens Hospital.
These various types of JA all have their own different symptoms, but some similarities include pain, joint swelling, redness, and warmth. This condition can also affect the eyes, skin, muscles, and gastrointestinal tract.. The exact cause of juvenile arthritis has still not been found by researchers. Some studies suggest that the most appropriate cause is the combination of genes the child receives. Regardless, the most important part to your childs health is having a proper diagnosis done by a physician. Here at Stem Cell International, our expert physicians conduct careful physical exams so we can get to the bottom of the condition. After we understand exactly what your child has, we will move on to developing a natural treatment plan that will be most effective to meet their needs and put them on the road to recovery. If your child is struggling from JA, give us a call and set-up an appointment to see what we can do for you.. ...
A new study published in the journal Pediatrics suggests that children treated with antibiotics have double the risk of developing juvenile arthritis compared to children who dont receive antibiotics.
Is your child in pain? So much pain that they struggle to get out of bed? This could be the first sign that your child has juvenile arthritis.
Researchers now say that antibiotics increase childrens risk of developing juvenile arthritis, a painful and chronic disease - with risk doubling.
... definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now!
The family journey-to-diagnosis with systemic juvenile idiopathic arthritis: a cross-sectional study of the changing social media presence Renee F Modica,1 Kathleen Graham Lomax,2 Pamela Batzel,3 Leah Shapardanis,3 Kimberly Compton Katzer,3 Melissa E Elder1 1Division of Pediatric Rheumatology, Immunology and Infectious Diseases, University of Florida, Gainesville, FL, USA; 2Immunology and Dermatology Medical Affairs, Novartis Pharmaceuticals Corporation, East Hanover, USA; 3Treato, Princeton, NJ, USA Background: Children with systemic juvenile idiopathic arthritis (SJIA) often encounter a delay between symptom onset and disease diagnosis, partly due to the broad differential of fever and lack of symptom recognition by providers. Families often seek multiple medical opinions and post on social media about their frustrations. This linguistic analysis observed the changing language patterns and social media posting behaviors of parents in the time leading to, during, and after SJIA diagnosis. Methods:
Juvenile arthritis comprises a variety of chronic inflammatory diseases causing erosive arthritis in children, often progressing to disability. These children experience functional impairment due to joint and back pain, heel pain, swelling of joints and morning stiffness, contractures, pain, and anterior uveitis leading to blindness. As children who have juvenile arthritis reach adulthood, they face possible continuing disease activity, medication-associated morbidity, and life-long disability and risk for emotional and social dysfunction. In this article we will review the burden of juvenile arthritis for the patient and society and focus on the following areas: patient disability; visual outcome; other medical complications; physical activity; impact on HRQOL; emotional impact; pain and coping; ambulatory visits, hospitalizations and mortality; economic impact; burden on caregivers; transition issues; educational occupational outcomes, and sexuality. The extent of impact on the various aspects of the
... Summary. Global Markets Directs, Systemic Idiopathic Juvenile Arthritis-Pipeline Review, H1 2016, provides an overview of the Systemic Idiopathic Juvenile Arthritis pipeline landscape. The report provides comprehensive information on the therapeutics under development for Systemic Idiopathic Juvenile Arthritis, complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in therapeutic development for Systemic Idiopathic Juvenile Arthritis and features dormant and discontinued projects. Global Markets Directs report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 ...
Illustration comparing a normal knee joint (left) and arthritic knee joint (right). The disease commonly occurs between ages 7 to 12 and affects 1 in 1000 children each year. It is known as systemic juvenile idiopathic arthritis. - Stock Image C027/6529
Results Fourteen patients (nine boys) were considered to have evidence of MAS, with age ranged from 4 months to 12 years.The primary diagnosis was systemic onset juvenile idiopathic arthritis.No medication was identified as trigger. Eleven had infections prior to MAS,specific infectious agents were identified in four. High fever, new onset hepatosplenomegaly, lymphadenopathy, liver dysfunction,abnormal lipid metabolism and hemophagocytosis were common clinical features.Two cases were with acute respiratory distress syndrome (ARDS),multiple organ failure (MOF) in three and three died. The perforin A91V (NCBI:SNP rs35947132) variant gene was detected in seven systemic onset juvenile idiopathic arthritis compolicated with MAS cases, but no mutation were found. Glucocorticoid, intravenous immunoglobulin, immunoimpressive therapy were effective and HP (Plasmapheresis) used in one serious case was also effective. ...
Results Twenty-one of 23 patients with onset sJIA had elevated neutrophil counts, while monocyte counts were elevated in only 5/23 patients. Many inflammatory markers were significantly elevated in serum of onset sJIA patients, among which several neutrophil specific proteins indicating the importance of this cell type. Neutrophils from onset sJIA patients showed an activated phenotype, reflected by higher ex vivo cell membraneexpression of FC-gamma receptors (CD32 and CD64), markers of secretory vesicles (CD35) and specific granules (CD66b). ROS production and degranulation were also enhanced in onset sJIA. Neutrophil phenotypenormalized when patients were in remission. In contrast to the hyperactivated status of neutrophils in active sJIA, PBMCs from these patients produced less Il-1b, IL-18, IL-6 and TNF-a upon TLR-stimulation compared to PBMCs from remission patients or HDs, suggesting tolerance after exposure to high TLR4 stimulating S100-levels in vivo. ...
Researchers report in Nature Genetics that they have increased the number of confirmed genes linked to juvenile idiopathic arthritis (JIA) from 3 to 17 - a finding that will clarify how JIA fits into the spectrum of autoimmune disorders and help identify potential treatment targets. Published online on April 21, 2013, the study involves an international research team that analyzed 2,816 JIA cases recruited from more than 40 pediatric rheumatology clinics. It was the largest collaborative patient population of JIA to date, including patient DNA samples from across the United States, Germany, and the United Kingdom, according to Susan Thompson, Ph.D., a researcher in the Division of Rheumatology at Cincinnati Childrens Hospital Medical Center who was a leader for the study. "These findings will help us understand how the long suspected genetic contributions to JIA are driving the disease process, with the ultimate goal being earlier and improved diagnosis and treatment," Dr. Thompson said. JIA is ...
Children with juvenile idiopathic arthritis (JIA) have a higher risk of cancer than children without JIA. The increased risk does not appear to be due to arthritis medications, but additional research is warranted. These results were published in Arthritis and Rheumatism.. Similar to adults with arthritis, children with JIA experience joint pain, swelling, tenderness, and stiffness. The condition affects an estimated 294,000USchildren under the age of 17.. Drugs known as TNF inhibitors may be used to treat arthritis in children and adults, but these drugs have been linked with a possible increase in the risk of certain types of cancer.. To explore cancer risk among children with JIA, researchers used US Medicaid records to identify 7,812 children with JIA. The cancer risk in these children was compared with the cancer risk in a large group of children without JIA. The children without JIA were selected from among children with either asthma or attention-deficit hyperactivity disorder.. For the ...
Planet Ayurveda provides best quality herbal remedies for ayurvedic treatment of Childhood Arthritis. Childhood Arthritis is known by another name Juvenile Arthritis, is a pediatric rheumatic disease, affecting individuals below the age of 16 years.
Areal bone mineral density is lower in women who have a history of juvenile idiopathic arthritis (JIA). In later life, these patients may be at risk for osteoporosis complications, including fragility fractures.
At the center of the comic book is Alex. His story is that of a typical young boy, about how he spent time with his friends and the adventures they shared throughout their childhood. Alex, however, was diagnosed with juvenile idiopathic arthritis (JIA) at 14 years old. "In my case, besides the inherent challenges of being a teenager, the biggest one in mine and my familys life was being diagnosed with this disease," says Alex. "We were all surprised and as a family experienced lots of different emotions - denial, frustration, worry and anxiety - because it was something unknown, because we had no idea how to react, because we couldnt believe that our lives were going to change for ever. At first, I wasnt able to do any sports, and later on, I was unable to walk.". Born out of a collaboration between the Autoimmune Diseases Patient Association (APAA) and Roche Pharma Romania, a comic book was developed to educate and inspire other children with JIA and their families. It has been distributed ...
COPENHAGEN -- Children with juvenile idiopathic arthritis continued to respond to abatacept (Orencia) for up to 30 months, researchers said here.
The aim was to develop prediction rules that may guide early treatment decisions based on baseline clinical predictors of long-term unfavorable outcome in juvenile idiopathic arthritis (JIA). In the Nordic JIA cohort, we assessed baseline disease characteristics as predictors of the following outcomes 8 years after disease onset. Non-achievement of remission off medication according to the preliminary Wallace criteria, functional disability assessed by Childhood Health Assessment Questionnaire (CHAQ) and Physical Summary Score (PhS) of the Child Health Questionnaire, and articular damage assessed by the Juvenile Arthritis Damage Index-Articular (JADI-A). Multivariable models were constructed, and cross-validations were performed by repeated partitioning of the cohort into training sets for developing prediction models and validation sets to test predictive ability. The total cohort constituted 423 children. Remission status was available in 410 children: 244 (59.5%) of these did not achieve remission
Juvenile idiopathic arthritis (JIA) is a common rheumatic disease in children and adolescents. Although JIA may cause secondary amyloidosis, this is a rare complication in patients with JIA and other rheumatic diseases. Many previous studies have revealed that common heterozygous or homozygous mutations in the MEFV gene are associated with systemic-onset JIA (SJIA). We herein report a case involving a 19-year-old female patient with difficult-to-control SJIA. She developed progressive proteinuria without clinical signs or symptoms of edema. Renal amyloidosis was diagnosed by renal pathologic examination, which demonstrated deposition of eosinophilic amorphous material in the interlobular arteries, arterioles, and interstitium. Electron microscopy showed fibrillary material deposits with a diameter of 8 to 10 nm. A heterozygous E148Q mutation in the MEFV gene was identified. Conventional disease-modifying anti-rheumatic drugs and etanercept had been used to treat the SJIA, but the disease could not be
Systemic-onset juvenile idiopathic arthritis is one type of juvenile arthritis. SoJIA/SJIA has some differences from other subtypes due to it being autoinflammatory and systemic in nature. Below is a list of studies and other information on diagnosing and treating SoJIA. … Continue reading →. ...
You must have seen an elderly family member complain of stiffness and joint pains who has had to alter lifestyle because of it. Life gets slower and painful of course. There are temporary causes and solutions that they resort in order to manage the pain. This is arthritis which is a condition that affects the movement of joints and causes pains and disability if left untreated.. Most people assume arthritis affects the old but be aware that this problem can come at any age. The most common forms of arthritis are osteoarthritis which is wear and tear of the joints over time and rheumatoid arthritis which is an autoimmune disease besides juvenile arthritis, another autoimmune disease in kids. Juvenile arthritis is very different from the kind of aches that plague the elderly. Kids with this condition suffer from all kinds of autoimmune forms of arthritis. It is an extremely serious condition where the bodys immune system attacks the joints causing extreme swelling, stiffness and long term ...
Alexander technique This technique was developed by an actor, F. M. Alexander, to improve his voice. He believed that the way we breathe affects the function of our bodies and that the relationship between the head, neck, and upper body are the primary controls of posture. Abnormal posture causes abnormal muscular tension in one muscle group and can adversely affect the whole body. Treatment with the Alexander technique usually involves individual or group lessons during which a teacher observes the posture and tension in a student. The teacher then explains, using touch and instructions, more efficient posture, movement, and breathing. The Alexander technique has not been adequately evaluated in well-designed studies. Apart from anecdotal experience, little scientific evidence is available with which to evaluate the Alexander technique as a therapy for arthritis-related problems.. alkaptonuria (ochronosis) This rare, inherited deficiency of the enzyme homogentisic acid oxidase results in ...
A recent study in the New England Journal of Medicine touted the efficacy of adult arthritis drugs methotrexate and leflunomide (Arava) in treating children with arthritis. Whereas methotrexate has been used for years to treat children with arthritis, it now has been shown to be effective at higher doses. The FDA has approved Arava for adult use but not for treating children. Patients given the higher dose of methotrexate had a 90% response rate, while patients taking Arava had a 68% response rate. Both drugs help control the white blood cells that cause inflammation and pain associated with arthritis. The study was funded by Sanofi-Aventis, manufacturer of both drugs. ...
The Nevada office of the Arthritis Foundation Pacific Region provide local resources including camps, conferences and resources to benefit kids and their families with arthritis and related diseases.
Having a child with a suppressed immune system has opened doors to many opportunities for adventures. But most of all learning how to live & cope with arthritis in a child who couldnt accurately express pain or feelings when first diagnosed to watching her grow into a little girl with the knowledge & use of language to share, express & report details is the biggest journey of all! This blog has been written during all of her milestones from a toddler to current elementary student. As she grows & gets older, we share our learnings of food, school and life! ...
JA means that the lining of one or more of your childs joints is inflamed. This causes pain and swelling. JA is long-term (chronic) condition.
Some of those differentially expressed genes have been shown to bind to HNF4a, a transcription factor that acts as an on-off switch for gene expression.. The researchers compared gene expression profiles from two cohorts of 14 patients each, all in remission from JIA-formerly known as juvenile rheumatoid arthritis-with those of 15 healthy controls.. The patients, who were followed every two to three months for at least a year, had been treated with two different standard medication regimens. ...
If your child starts complaining about joint pain, it can be difficult to take them seriously at first. Theyre so young; how could they possibly be experi
Diagnosis Code M08.972 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
As an actress, Emily Cipriani is adept at covering up problems. The 15-year-old has a reputation for smoothly handling mishaps in a play, whether providing ad-libs during a scene gone awry or discreetly fixing a technical malfunction. As a hurting child, though, covering up had its limits.
Diagnosis Code M08.90 information, including descriptions, synonyms, code edits, diagnostic related groups, ICD-9 conversion and references to the diseases index.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
There are several different types of juvenile arthritis. The most common form is juvenile idiopathic arthritis, also known as juvenile rheumatoid arthritis. This chronic inflammatory disease describes a clinically different group of arthritis (joint inflammation), which begins before the age of 16 and lasts for at least six weeks. The cause of disease is still…
Patients who previously withdrew are excluded Responders are patients who met all of the following criteria for inactive disease at all visits in the 6 months (180 days) prior to and including the visit assessment day: i. Number of active joints = 0. ii. Absence of lymphadenopathy, hepatomegaly or splenomegaly in the nearest non-missing physical examination prior to or after the week assessment day. This could include results outside of the time window.. iii. Absence of symptomatic serositis adverse event. iv. In the 14 days preceding the week assessment day no fever (temperature ,=37.5 C) or rash characteristic of sJIA. v. Normal ESR as defined by an ESR ,20 mm/hr regardless of age and sex.. vi. iv. Physician global assessment VAS ,=10. LOCF rule applied to missing number of active joints, ESR and Physician global assessment VAS. ESR = Erythrocyte Sedimentation Rate. VAS = Visual Analogue Scale. Data presented up to the point of entry into the Alternative Dosing Schedule. ...
Many children with sJIA may have a delayed onset of arthritis and so fail to fulfil the ILAR criteria for sJIA. This study was undertaken to determine whether the Yamaguchi criteria (for adult onset Stills disease) is useful in classification of chi
Replacement of the shoulder in juvenile idiopathic arthritis is not often performed and there have been no published series to date. We present nine glenohumeral hemiarthroplasties in eight patients with systemic or polyarticular juvenile idiopathic arthritis. The mean follow-up was six years (59 to 89 months). The mean age at the time of surgery was 32 years. Surgery took place at a mean of 27 years after diagnosis. The results indicated excellent relief from pain. There was restoration of useful function which deteriorated with time, in part because of progression of the systemic disease in this severely affected group. No patient has required revision to date and there has been no radiological evidence of loosening or osteolysis around the implants. We discuss the pathoanatomical challenges unique to this group. There was very little space for a prosthetic joint and, in some cases, bony deformity and the small size necessitated the use of custom-made implants.
The Roche Groups immunology medicines include: Actemra/RoActemra (tocilizumab) for rheumatoid arthritis, polyarticular juvenile idiopathic arthritis (pJIA), systemic juvenile idiopathic arthritis (sJIA) and giant cell arteritis (GCA) and for the treatment of severe or life-threatening chimeric antigen receptor (CAR) T cell-induced cytokine release syndrome (CRS); Rituxan/MabThera (rituximab) for rheumatoid arthritis granulomatosis with polyangiitis and microscopic polyangiitis and for pemphigus vulgaris (PV); Xolair (omalizumab) for allergic asthma and chronic idiopathic urticaria (CIU); Pulmozyme (dornase alfa) for cystic fibrosis; and Esbriet (pirfenidone) for idiopathic pulmonary fibrosis (IPF). Roche has more than 15 investigational medicines in clinical development for immunological diseases that include asthma, autoimmune diseases, rheumatoid arthritis, ulcerative colitis and Crohns disease.. ...
In Part I participants received open label 4 mg/kg canakinumab subcutaneous injection every 4 weeks for up to 32 weeks. For the first 8 weeks Part Ia (4 weeks) and Ib (4 weeks) patients maintained a stable oral steroid dose (prednisone or equivalent) followed by Ic an up to 20 week steroid tapering period and then Id a 4 week stable steroid dose period. Participants were then randomized to receive either 4 mg/kg canakinumab subcutaneous injection or placebo comparator in Part II and remained on the stable oral steroid dose for 24 weeks. At 24 weeks in Part II participants with a ,0.2 mg/kg and ≤ 0.5 mg/kg and no flare could restart steroid tapering. If the steroid dose was ≤ 0.2 mg/kg participants continued to maintain their current dose for the remainder of Part II ...
Patients who have completed Open-label phase and responded to MRA will move on to Double blind phase, in which the responders will be randomized to receive
Purpose: Juvenile idiopathic arthritis-associated uveitis (JIAU) is the most common uveitis entity in childhood. As S100A8/A9 and S100A12 proteins are valuable biomarkers in childhood arthritis, we investigated the occurrence of these proteins in childhood uveitis. Methods: Serum samples from patients with JIAU (n = 79) or idiopathic anterior uveitis (IAU, n = 24), as well as from nonuveitic controls (n = 24), were collected. Furthermore, aqueous humor samples (JIAU n = 17, nonuveitic controls n = 16, IAU n = 12) were obtained. Samples were analyzed for S100A8/A9 and S100A12 protein levels by ELISA. Intergroup comparisons were performed, involving patient data, clinical data, and S100 levels. Results: S100A8/A9 and S100A12 serum levels were elevated in IAU and JIAU patients as compared to nonuveitic controls (all P , 0.05). S100 serum levels in JIAU patients were higher in active arthritis (not significant; P = 0.289 for S100A8/A9 and P = 0.196 for S100A12) and active uveitis (P = 0.010 for ...
A serious complication of childhood systemic inflammatory disorders that is thought to be caused by excessive activation and proliferation of T-LYMPHOCYTES and MACROPHAGES. It is seen predominantly in children with systemic onset JUVENILE IDIOPATHIC ARTHRITIS ...
Early changes in gene expression and inflammatory proteins in systemic juvenile idiopathic arthritis patients on canakinumab therapy. Arndt Brachat, Alexei Grom, Nico Wulffraat, Hermine Brunner, Pierre Quartier, Riva Brik, Liza McCann, Huri Ozdogan, Lidia Rutkowska-Sak, Rayfel Schneider, Valeria Gerloni, Liora Harel, Maria Terreri, Kristin Houghton, Rik Joos, Daniel Kingsbury, Jorge Lopez-Benitez, Stephan Bek, Martin Schumacher, Marie-Anne Valentin, Hermann Gram, Ken Abrams, Alberto Martini, Daniel Lovell, Nanguneri Nirmala, Nicolino Ruperto, for the Pediatric Rheumatology International Trials Organization (PRINTO) and the Pediatric Rheumatology Collaborative Study Group (PRCSG) Arthritis Research & Therapy 2017, 19:13 (23 January 2017) ...
Purpose : Juvenile idiopathic arthritis (JIA)-associated uveitis is an indolent yet serious condition with poor visual prognosis. Our purpose is to present long-term clinical outcomes in patients treated with immunomodulatory therapy (IMT) in the long-term. Methods : A retrospective analysis of JIA-associated uveitis patients presenting between 2005 to 2016 with a minimum of 3 years follow-up was conducted. Information collected included presenting and final visual acuities (VA), development of band keratopathy, cataract and glaucoma, IMT used as well as side effects. Remission was defined as successful inflammation-free weaning off of IMT. Results : A total of 61 patients with JIA-associated uveitis were identified, 88.5% were female. Mean age at presentation of 38 of patients not in remission (NR) was 16.2 years (range 3-44 years), and mean follow-up was 106.1 months SEM=4.69. Of the 23 patients in the remission group, mean age at presentation was 13.5 years (range 4-39), and mean follow-up ...
Background The original version of the Childhood Health Assessment Questionnaire (CHAQ30orig) suffers from a ceiling effect and hence has reduced clinical validity. The purpose of this study was to...
We provide the opportunity to meet new friends who understand the challenges you face, through our support groups.. Arthritis & Osteoporosis NSW community groups. There are currently 29 branches and support groups throughout New South Wales. These comprise members who join together to support each other and gain knowledge to help manage their condition. Most groups meet monthly to hear a guest speaker and/or discuss topics related to arthritis and osteoporosis. Most importantly, our community groups offer support and the opportunity to build friendships. If there is no branch or support group in your area, why not contact us and help start one up!. Support for parents with kids who have arthritis. Arthritis & Osteoporosis NSW recognises that children who have juvenile idiopathic arthritis experience severe pain, stiffness, fatigue and muscle weakness on a daily basis. Juvenile arthritis now affects 1 in every 800 Australian children. If your child has arthritis, as a member you will have access ...
Juvenile Idiopathic Arthritis (JIA) and Education in Primary School Children: 10.4018/978-1-4666-9452-1.ch004: This chapter per the authors describes the impact that juvenile idiopathic arthritis (JIA) has on the functioning of children within elementary school
TY - JOUR. T1 - Adalimumab in combination with methotrexate for refractory uveitis associated with juvenile idiopathic arthritis. T2 - a RCT. AU - Ramanan, Athimalaipet V. AU - Dick, Andrew D. AU - Jones, Ashley P. AU - Hughes, Dyfrig A. AU - McKay, Andrew. AU - Rosala-Hallas, Anna. AU - Williamson, Paula R. AU - Hardwick, Ben. AU - Hickey, Helen. AU - Rainford, Naomi. AU - Hickey, Graeme. AU - Kolamunnage-Dona, Ruwanthi. AU - Culeddu, Giovanna. AU - Plumpton, Catrin. AU - Wood, Eifiona. AU - Compeyrot-Lacassagne, Sandrine. AU - Woo, Patricia. AU - Edelsten, Clive. AU - Beresford, Michael W. PY - 2019/4/1. Y1 - 2019/4/1. N2 - BACKGROUND: Children with juvenile idiopathic arthritis (JIA) are at risk of uveitis. The role of adalimumab (Humira®; AbbVie Inc., Ludwigshafen, Germany) in the management of uveitis in children needs to be determined. OBJECTIVE: To compare the efficacy, safety and cost-effectiveness of adalimumab in combination with methotrexate (MTX) versus placebo with MTX alone, with ...
Juvenile idiopathic arthritis is the most common type of arthritis in children. Learn about juvenile idiopathic arthritis symptoms, diagnosis, and treatment.
Its because mainstream medicine has their head buried in the sand of "unawareness" (to be kind).. The bottom line of a Medscape article on New Guidelines and Recommendations pertaining to juvenile arthritis is that early exposure to antibiotics in childhood greatly increases the risk of developing juvenile idiopathic arthritis (JIA), an autoimmune disease. It didnt seem to matter what type of antibiotic was used. *. Antibiotics are known to wipe out the good bacteria along with the bad, and thus can contribute to an ill-functioning gut. Antibiotics seem to be handed out like candy for just about every childhood ailment.. Its only been in the last few years that the importance of the gut biome, the condition of your gut, has been seriously recognized by a handful of forward-thinking doctors as being linked to autoimmune disease. Youve probably heard that 70-80% of the immune system lies within the gut. So if you have a healthy gastrointestinal system youre probably in pretty good shape, and ...
That is so that you dont change into pregnant while on medicine which can harm your ampicillni. This historic methods function is to find out the time intervals during which a lady is extra prone to get pregnant with a baby of a desired intercourse. The commonest kind of juvenile arthritis is juvenile idiopathic arthritis, previously generally known as mf rheumatoid arthritis. Some days Im more tired than others. When you have hassle staying in your goal vary or have frequent low blood glucose ranges, talk to qmpicillin well being care workforce about revising your therapy plan. When you can ampicillin tr 500 mg and pregnancy show eligibility, our fees are 1,300. Sure, babies at this stage of being pregnant could have their hair growing, and in the direction of ampicilpin top of the sixteenth week,your baby will begin to develop eyelashes and eyesight at a quicker pace. Because of this if youre sitting on a chair and you no heartburn during pregnancy and the phone rings, strive not to jerk ...
Arthritis is a painful disorder of the joints, normally associated with older people. But, children as young as 3 yrs also suffer from a form of arthritis known as Juvenile Idiopathic Arthritis (JIA)
This sheet talks about exposure to tocilizumab in a pregnancy or while breastfeeding. This information should not take the place of medical care and advice from your health care provider.. What is tocilizumab?. Tocilizumab is a prescription medication used for the treatment of rheumatoid arthritis (RA), systemic or polyarticular juvenile idiopathic arthritis (sJIA, pJIA) and giant cell arteritis (GCA). Tocilizumab is an antibody (a protein made by the bodys immune system) that binds and blocks IL-6 (a protein that causes inflammation). Tocilizumab is used to reduce symptoms and joint damage in patients with rheumatoid arthritis and juvenile idiopathic arthritis. Tocilizumab is given in a healthcare providers office once a month as an infusion into a vein. It can also be injected under the skin. Tocilizumab is sold under the brand name Actemra®.. How long does tocilizumab stay in the body? Should I stop taking it before I try to get pregnant?. Individuals break down medications at different ...
Sarah Ringold, M.D., M.S., Audrey Hendrickson, M.P.H, CCRP, Leslie Abramson, M.D., Timothy Beukelman, M.D., MSCE, Peter R. Blier, M.D., Ph.D., John Bohnsack, M.D., Elizabeth C. Chalom, M.D., Harry Gewanter, M.D., Beth Gottlieb, M.D., M.S., Roger Hollister, M.D., Joyce Hsu, M.D., M.S., Andrea Hudgins, M.D., Norman T. Ilowite, M.D., Marisa Klein-Gitelman, M.D., M.P.H, Carol Lindsley, M.D., Jorge M. Lopez Benitez, M.D., F.A.A.P., Daniel J. Lovell, M.D., M.P.H, Tom Mason, M.D., Diana Milojevic, M.D., Lakshmi N. Moorthy, M.D., M.S., Kabita Nanda, M.D., et al; A Novel Method to Collect Medication Adverse Events in Juvenile Arthritis: Results from the Childhood Arthritis and Rheumatology Research Alliance Enhanced Drug Safety Surveillance Project (EDSSP), Accepted for publication in Arthritis Care and Research 2014. ...
Hi, my name is Sheridan. Now almost 35 years old, I was diagnosed with Juvenile Rheumatoid Arthritis at the age of two. Most people dont know that kids develop arthritis too. In fact, three kids in a thousand, or about one in every school, live with juvenile arthritis. Its a type of inflammato ...
Juvenile rheumatoid arthritis can it kill you - With juvenile rheumatoid arthritis can I take glucosamine? Yes, you can take it. But glucosamine is useless for juvenile idiopathic arthritis. You should be under the care of a pediatric rheumatologist.
The Childhood Arthritis & Rheumatology Research Alliance (CARRA) began in 2000 as a grassroots initiative among a small number of pediatric rheumatologists in the U.S. and Canada seeking to establish an inclusive, collaborative research network. The overall mission and supporting guiding principles that outlined scientific, leadership and operational elements were crafted at a meeting in 2001, and the initial scientific agenda and criteria for studies to be undertaken by the network were established in 2002.. CARRA was envisioned as a network that would enable widespread research participation, thereby ensuring the future of academic pediatric rheumatology, which was endangered at the time. Three crucial components were identified at the meeting that continue to form the bedrock of the current organization:. ...
Rheumatoid Arthritis; Osteoarthritis; Juvenile Arthritis; Other Types of Arthritis; Arthritis Pain; previous joint injury overuse of the joint weak thigh muscles and genetics. Arthritis Due To Excess Levels Of Uric Acid In Blood Joint Medicine Pain Clinic Mayo has served a variety of purposes including topical use for joint or musculoskeletal pain. administering a child care center syllabus.. Basically everything I like to do in focusing on the ACL injury as well as the other knee where I have quite a bit of arthritis. Home , Heel Pain , Stress Fractures. Includes back pain articles and tips for reducing pain. Rheumatoid arthritis can be a difficult disease to parvovirus reactive arthritis treating fingers diagnose infection including rheumatic fever Lyme disease fungal arthritis Fifth disease tuberculosis Other spondyloarthropathies include psoriatic arthritis rheumatoid arthritis and gum disease nursing reactive arthritis ucellar spondylitis enteropathic arthritis and sacroiliitis8. Defining ...
About Rheumatoid Arthritis. RA is a chronic inflammatory disease that affects approximately one percent of the adult population worldwide and can start at any age, but usually occurs between 40 and 70 years of age. RA can cause pain, stiffness, swelling and limited motion and function of multiple joints. In RA, joint damage can significantly worsen over time, especially if left untreated. Joint damage may impair function, and potentially disable some patients.. About ENBREL. ENBREL is a soluble form of a fully human tumor necrosis factor (TNF) receptor with efficacy and safety evaluated in clinical studies over the past 19 years. ENBREL was first approved in the U.S. in 1998 for moderate to severe rheumatoid arthritis and was later approved to treat children and adolescents with moderate to severe juvenile rheumatoid arthritis (now called polyarticular juvenile idiopathic arthritis) in 1999. In 2004, ENBREL was approved in the U.S. to treat adult patients with chronic moderate to severe plaque ...
Results After a mean followup time for JIA of 4.6 years (range 0.08-14.17), 86/223 patients (38.6%) had developed TMJ arthritis. The rate of TMJ involvement differed significantly among JIA subtypes (p = 0.0016), with 61% in extended oligoarticular, 52% in polyarticular rheumatoid factor (RF)-negative, 50% in psoriatic, 36% in systemic, 33% in polyarticular RF-positive, 33% in persistent oligoarticular, 30% in unclassified JIA, and 11% in enthesitis-related arthritis. The rate of TMJ involvement in our cohort was statistically significantly lower for patients who were HLA-B27-positive (p = 0.0002). In a multivariate analysis, the association of the following factors was confirmed: JIA subtype (p = 0.0001), a higher erythrocyte sedimentation rate (ESR) at diagnosis (p = 0.0038), involvement of joints of the upper extremity (p = 0.011), the absence of HLA-B27 (p = 0.023), and younger age at onset of JIA (p = 0.050). ...
Health, By Mary Brophy Marcus HealthDay Reporter ...WEDNESDAY Dec. 19 (HealthDay News) -- Children who suffer from a rare...Two studies published in the Dec. 20 issue of the New England Journ... Systemic juvenile idiopathic arthritis is a form of severe arthritis ...The disease is one of seven types of juvenile idiopathic arthritis tha...,Drugs,Hold,Promise,for,Severe,Juvenile,Arthritis,Patients,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
If it is actually not constrained to joint inflammation relief specifically, this is actually most definitely relevant, as well as it will definitely help given that gives our team good and also applicable corresponding info on the topic. I really hope significantly that it interests you and all the others looking for relevant information worrying arthritis alleviation.. Vertebrae arthritis, psoriatic arthritis, infectious joint inflammation, and/or juvenile arthritis might be caused by years from unsafe actions. Dangerous motions lead to irregular joint tension and also lead to uncomfortable gout pain arthritis, joint inflammation in hands, back joint inflammation, and/or foot joint inflammation for example. Thankfully, arthritis diet plans, joint inflammation workout, and/or arthritis drug have actually worked in joint inflammation alleviation. Joint inflammation analysis, arthritis societies, and also joint inflammation physicians have actually assisted ratings from arthritis details to ...
Ashley Macha, writing in Health online, reported on four arthritis myths. This was done as part of a May is Arthritis Awareness Month campaign, featuring Joe Montana, Hall of Fame quarterback.. 1. Myth: Arthritis only affects the aging. Reality: This is the most common misconception. Anyone, at any age can be affected, according to the Arthritis Foundation. The most common type is osteoarthritis, the kind due to wear and tear on the joints over time (which is what Montana has), but also rheumatoid arthritis, an autoimmune disease that can occur at any age, juvenile arthritis, an autoimmune disease in children, and other types.. 2. Myth: Joint health is not a serious issue. Reality: The population of those with arthritis in the United States is increasing, with approximately 70 million Americans predicted to have arthritis by 2030. It is the number one cause of disability in the United States.. 3. Myth: Patients with arthritis should avoid exercise. Reality: The Arthritis Foundation recommends ...
Arthritis is a joint disorder. Arthritis can affect any joint, any part of the body. There are close to 100 forms of arthritis.The cause of arthritis depends on its form. Determining a single cause of arthritis can be difficult. The major types of arthritis are Osteo arthritis, Rheumatoid Arthritis, Fibromyalgia and juvenile arthritis.. Symptoms: ...
Most people think of math when they think acute and of pot when they think of chronic.. Quite simply. acute means short-term and chronic mean long-term in the medical world.. An acute illness would be one that ends after a while. The flu or a cold are great examples. Breaking your leg or similar things are more long-term but still considered acute for the most part.. A chronic illness is one that is recurrent or long-term - essentially a life-long illness. Juvenile arthritis and Stills disease are examples of this.. Some people lump certain types of cancers in with long-term or chronic illness, like breast cancer. This is definitely fine I think. On the other hand, some people lump some chronic illnesses like Stills in with terminal illness. While it is likely that my disease will kill me in one way or another, I prefer not to look at it like this.. ...
OBJECTIVE: Juvenile idiopathic arthritis (JIA) is characterized by chronic arthritis and an autoimmune etiology. In several autoimmune diseases, including rheumatoid arthritis (RA), an association with the 4q27 locus has been reported. We undertook this study to investigate the possible role of the 4q27 locus in JIA. METHODS: A case-control association study was conducted, with a total of 655 Caucasian JIA patients and 791 healthy controls divided into 2 independent sample sets. The rs6822844 marker in the 4q27 locus was genotyped. RESULTS: In the first and larger sample set, a 5% decrease in T allele frequency was observed in patients compared with controls (allelic odds ratio [OR] 0.72 [95% confidence interval 0.55-0.95], P = 0.019), and in the second set, a 3% decrease was observed (allelic OR 0.81 [95% confidence interval 0.61-1.09], P = 0.169). The combined data set generated an OR of 0.76 (95% confidence interval 0.62-0.93, P = 7.08 x 10(-3)). When the different JIA subtypes were analyzed ...
Yesterday, the FDA approved Actemra for use in the treatment of Systemic-Onset Juvenile Idiopathic Arthritis. Also known as Stills Disease, Ive written about this before. You might be saying, I dont have Stills, so why would I care? I think it matters, because its an important step and might be the start of a new…
School and sporting activities, partying and playing arent too much fun when mobility is compromised and painful flare-ups take so much enjoyment away. Depending on the type and severity of JIA, pain and discomfort experienced as well as the joints affected can change not only on a daily basis, but from one hour to the next.. And the pain of juvenile arthritis is not only physical. JIA can impact on friendships, self esteem and confidence. The sense of adventure, motivation to try new things, feelings of belonging as well as academic achievement, artistic expression, and athletic prowess can be undermined. Puberty can be delayed by some medications, and stiff joints and altered growth patterns can affect self image.. Support is vital; as is understanding.. With accurate early diagnosis and ongoing treatment, going to school, playing sport, being with friends, learning a musical instrument, and holidaying with the family should still be part of normal life for children with JIA.. ...
Quick question. I had polyarticular juvenile arthritis and psoriasis as a kid; now, after having my babies, it seems my arthritis is out of remission. I have been diagnosed three times, twice with sero negative RA and once with psoriatic arthritis. I had a CT scan that showed some damage to SI L34 joints and knee joints, and X-ray confirming knee damage, but my understanding is an MRI i more sensitive, and I am confident if an MRI were done it would show more damage to others areas, especially considering I cant even move my shoulders for more than a year now. However, I had to pull teeth to get them to give me an x-ray on my knee to prove damage, and while some x-rays on other joints came back neg, I know x-rays are not that sensitive and MRI are MUCH better for detecting early stage RA. I cant seem to get a doc to write a prescription for one (they are sometimes retards). So, does anyone know how to go about getting an MRI without a doctors referral? I called the center here and they said ...
Joint disease is a major cause of disability in the UK, affecting people of all ages, particularly the elderly. Currently, 29% of adults report being affected by arthritis or joint pain, which translates to over 13 million people across the UK.1 The prevalence of joint disease is higher amongst women, those aged over 55 and those from less affluent populations.1 Most sufferers of joint disease describe their condition in terms of joint pain or back pain, with fewer reporting having a specific arthritic condition. In fact, it can sometimes be difficult to determine where joint pain ends and arthritis begins. The term arthritis and related conditions can be used to cover a myriad of over 200 different complaints, of which the most common are osteoarthritis, rheumatoid arthritis, juvenile arthritis, gout and ankylosing spondylitis.1. Was this article helpful?. ...
Who can develop an autoimmune condition?. While no one knows exactly what triggers the immune system to make the mistake of attacking healthy tissue, some studies indicate a genetic component, combined with environment, may increase the risk for certain arthritis. This explains why people who experience symptoms associated with inflammatory arthritis usually have a relative who also has some form of autoimmune disease. Smoking tobacco can also be a trigger and should be avoided for numerous reasons. An inflammatory autoimmune condition can occur at any age. Right now in the United States, there are 300,000 children with inflammatory juvenile arthritis. In fact, rheumatic disease often strikes at the prime of life, with two-thirds of patients under age 65.. In many cases, the diseases are dramatic and debilitating at the time of onset. These are chronic conditions that cannot be cured. As a result, a diagnosis of an autoimmune or inflammatory disease can be stressful for the patient and his or ...
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Yes, we said 4000 children in Arizona alone suffer each day from debilitating ARTHRITIS! The Arthritis Foundation makes sure these children and their families can get the help they need in support, resources, and research! However, they can t do it alone These families find a tremendous amount of support at the American Juvenile Arthritis Organization (AJAO) Conference and this year it is being held right here in Arizona. It takes people like you to get families like this to the conference. Click below to find out how you can help! http://www.avimailer.com/af/[email protected] -------------- next part -------------- An HTML attachment was scrubbed... URL: http://iubio.bio.indiana.edu/bionet/mm/dros/attachments/20030515/e6401402/attachment.html ...
Arthritis and Osteoporosis Queensland : Information and support for all types of arthritis including osteoarthritis, rheumatoid and juvenile arthritis
Arthritis and Osteoporosis Queensland : Information and support for all types of arthritis including osteoarthritis, rheumatoid and juvenile arthritis
A group of diseases characterized by inflamed joints, pain and tenderness. Includes conditions such as rheumatoid arthritis, psoriatic arthropathy, inflammatory bowel disease, scleroderma, juvenile arthritis and lupus.. ...
HLA-DR12(DR12) is a HLA-DR serotype that recognizes the DRB1*1201 to *1203, *1206. DR12 serotype is a split antigen of the older HLA-DR5 serotype group which also contains the similar HLA-DR11 antigens. The table above describes the efficiency of serological typing of DR12 and DR5. Serotypes are unknown the following alleles: DRB1*1204,*1205 to *1207 to *1215 There are only 2 common allels for DRB1*12, *1201 and *1202. *1202 is more common on the West Pacific Rim and particularly Indochina and the South Pacific. DR12 is associated with vulval lichen sclerosus, and undifferentiated spondyloarthritis. DRB1*1201 is associated with iritis in juvenile arthritis, primary antiphospholipid syndrome, tiopronin intolerance in rheumatoid arthritis, adult chronic articular Stills disease DRB1*1202 is found to be increased in narcolepsy associated sudden death syndrome in the Thai population, and narcolepsy in the Japanese population. DRB1*12:DQA1*0505:DQBA1*0301 haplotype: DR12-DQ7.5/DR7-DQ2.2 is a ...
2013 JA Highlights. Every year the Arthritis Foundation looks forward to planning juvenile arthritis programs that will take place throughout the Pacific Region. In addition to hosting our SIX SUMMER CAMPS (at least one in every Pacific Region state this year), we also host JA Symposiums, Family Fun Days, and Family Weekend Camps. We are also lucky to partner with other nonprofits to host family support sessions like "Families Living with Rheumatic Diseases" and programs through CoachArt! One of the Arthritis Foundations biggest partners, The Painted Turtle, is highlighted below. This past year, we implemented an awesome welcome backpack kit called S.A.K. - Supporting Arthritis Kids. The S.A.K. program is especially designed for families with children who are newly diagnosed with a rheumatic disease or families that are new to the Arthritis Foundation. The backpack is filled with educational materials and fun activities for the family. So far, we have been able to serve nearly 1,000 new ...
Looking for online definition of juvenile rheumatoid arthritis in the Medical Dictionary? juvenile rheumatoid arthritis explanation free. What is juvenile rheumatoid arthritis? Meaning of juvenile rheumatoid arthritis medical term. What does juvenile rheumatoid arthritis mean?
Synonyms for Adult onset Still's disease in Free Thesaurus. Antonyms for Adult onset Still's disease. 1 synonym for Stills disease: juvenile rheumatoid arthritis. What are synonyms for Adult onset Still's disease?
... is a medical subspecialty concerned with diagnosis and therapy of rheumatic diseases. Physicians specializing in rheumatology are rheumatologists who deal with clinical problems involving joints, soft tissues, autoimmune diseases, vasculitis, and heritable connective tissue disorders. Pediatric Rheumatology disease influences the joints, muscles and connective tissues of Child, Infant and Adolescent. Numerous rheumatic ailments are chronic conditions. A few, similar to osteoarthritis, are the consequence of wear and tear. Others, for example, rheumatoid arthritis, are immune system problems. Common Rheumatic disorders are Lyme disease, Systemic lupus Erythematosus, Behcets Disease, Polymyalgia Rheumatica, Rheumatic fever. ...
Rider LG, Werth VP, Huber AM, Alexanderson H, Rao AP, Ruperto N, Herbelin L, Barohn R, Isenberg D, Miller FW. Measures of adult and juvenile dermatomyositis, polymyositis, and inclusion body myositis: Physician and Patient/Parent Global Activity, Manual Muscle Testing (MMT), Health Assessment Questionnaire (HAQ)/Childhood Health Assessment Questionnaire (C-HAQ), Childhood Myositis Assessment Scale (CMAS), Myositis Disease Activity Assessment Tool (MDAAT), Disease Activity Score (DAS), Short Form 36 (SF-36), Child Health Questionnaire (CHQ), physician global damage, Myositis Damage Index (MDI), Quantitative Muscle Testing (QMT), Myositis Functional Index-2 (FI-2), Myositis Activities Profile (MAP), Inclusion Body Myositis Functional Rating Scale (IBMFRS), Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), Cutaneous Assessment Tool (CAT), Dermatomyositis Skin Severity Index (DSSI), Skindex, and Dermatology Life Quality Index (DLQI). Arthritis Care Res (Hoboken). 2011 Nov;63 Suppl ...
ANTERIOR UVEITIS Description: Audio discussion (with clinical photos) regarding the background information, the differential diagnosis and the management of acute and chronic uveitis. Course Outline: Review of Clinical Anatomy I. Background Information on Uveitis A. Definition B. Classification C. Incidence and Prevalence of Uveitis (How Much?) D. Epidemiology and Demography (Who, When, and Where?) E. Etiology II. Primary Care of Acute Anterior Uveitis A. Subjective B. Objective C. Assessment D. Plan E. Follow-up III. Chronic Anterior Uveitis A. General Considerations B. Clinical Medicine C. Specific Diseases 1. Ankylosing Spondylitis 2. Behcet\s Syndrome 3. Crohn\s Disease (Regional Enteritis) 4. Fuch\s Heterochomic Iridocyclitis 5. Glaucomatocyclitic Crisis (Posner Schlossman Syndrome) 6. Juvenile Rheumatoid Arthritis (JRA) 7. Juvenile Xanthogranuloma (JXG) 8. Intermediate Uveitis (Pars Planitis) 9. Reiter\s Syndrome 10. Rheumatoid Arthritis 11.
Retrospective study. To evaluate the radiological results of fusion with segmental pedicle screw fixation in juvenile idiopathic scoliosis with a minimum 5-year follow-up. Progression of spinal deformity after posterior instrumentation an
Cataract is one of the most common and visually debilitating complications of pediatric uveitis. It develops as a consequence of chronic inflammation and steroid use and is seen most often in juvenile idiopathic arthritis (JIA)-associated uveitis. Cataract extraction with intraocular lens (IOL) insertion has been carried out with a measure of success in non-uveitic pediatric eyes, but in cases of uveitis, multiple factors affect the final outcome. Chronic inflammation and its sequelae such as band keratopathy, posterior synechiae, and cyclitic membranes make surgical intervention more challenging and outcome less certain. Postoperative complications like increased inflammation, glaucoma, posterior capsular opacification, retrolental membranes, and hypotony may compromise the visual outcome. Early refractive correction is imperative in pediatric eyes to prevent amblyopia. The use of contact lenses and intraocular lenses in pediatric uveitic eyes were fraught with complications in the past. Surgical
Examine the full spectrum of rheumatologic diseases and non-rheumatologic musculoskeletal disorders in children and adolescents, including the presentation, differential diagnosis, course, management, and prognosis of every major condition. Determine indication for procedure. Besides the clinical assessment, the symmetry of joint involvement was established by synovial fluid SF analysis which included both mononuclear cell MNC count and cytokine analysis. Haddad and Winchesters Clinical Management of Poisoning and Drug Overdose. Comparison of triamcinolone hexacetonide and triamcinolone acetonide in the intra-articular treatment of pauciarticular rheumatoid arthritis in infants [abstract].. Clin Exp Rheumatol Rheumatology Vol. Leading authors in their field have summarized these concepts to provide an authoritative, comprehensive guide to help clinicians safely and effectively use corticosteroids in their pediatric patients. A combination of systematic review and clinicians beliefs in ...
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Rheumatoid arthritis, including juvenile idiopathic arthritis; osteoarthritis; acute pain.. As per diclofenac. ... Rheumatoid arthritis; osteoarthritis; ankylosing spondylitis; juvenile idiopathic arthritis; inflammatory pain; heavy menstrual ... Rheumatoid arthritis.. As per diclofenac. Ethenzamide. Comes in free form; salicylate.. As per diclofenac.. PO.. Not available. ... Osteoarthritis; rheumatoid arthritis.. As per diclofenac. Ufenamate. No data.. No data.. Topical.. No data.. Inflammatory skin ...
Juvenile idiopathic arthritis. Lyme disease, which is transmitted by ticks and is characterized by debilatating polyarthritis, ... Septic arthritis, a severe infection of the joint that can lead to permanent joint damage. Spondyloarthropathies. Viral ... Rheumatic, such as ankylosing spondylitis, rheumatoid arthritis, gout. Others, such as fractures, osteoarthritis, Paget's ... such as osteoarthritis and gouty arthritis are rare in children, as these diseases are a sequelae of chronic wear and tear for ...
Arthritis in children. Inflammatory. Idiopathic. *Juvenile idiopathic arthritis. Inflammatory disease. *Inflammatory bowel ...
Arthritis in children. Inflammatory. Idiopathic. *Juvenile idiopathic arthritis. Inflammatory disease. *Inflammatory bowel ...
Arthritis in children. Inflammatory. Idiopathic. *Juvenile idiopathic arthritis. Inflammatory disease. *Inflammatory bowel ...
Manners, Prudence Joan; Bower, Carol (2002-07-01). "Worldwide prevalence of juvenile arthritis why does it vary so much?". The ... doi:10.1007/s11916-003-0035-z. "Juvenile rheumatoid arthritis Symptoms - Mayo Clinic". Mayo Clinic. Retrieved 2017-03-07. ... "Juvenile fibromyalgia Symptoms - Mayo Clinic". Mayo Clinic. Retrieved 2017-03-07. Neumann, L.; Buskila, D. (2003). " ...
For use for rheumatic fever, juvenile arthritis, Kawasaki disease References[edit]. *^ a b c d "Essential medicines". World ... Juvenile joint diseases[edit]. *Acetylsalicylic acid (aspirin)[note 90]. Notes[edit]. An α indicates the medicine is only on ...
Juvenile rheumatoid arthritis causes persistent pain and swelling in joints. Visual impairments as defined by the Royal ... "Juvenile rheumatoid arthritis: definition". Mayo Clinic. "Vision". The Royal Institute for Deaf and Blind Children. "What is ...
"HLA antigens in juvenile arthritis. Genetic basis for the different subtypes". Arthritis Rheum. 26 (1): 35-8. doi:10.1002/art. ... Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C (1980). "HLA-DR5 in juvenile rheumatoid arthritis ... DR5 is associated with persistent generalized lymphadenopathy (PGL) and Kaposi sarcoma in AIDS, juvenile rheumatoid arthritis, ... Arthritis Rheum. 38 (9): 1340-1. doi:10.1002/art.1780380925. PMID 7575732. Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van ...
link) Job-Deslandre, C (January 2007). "Idiopathic juvenile-onset systemic arthritis". Orphanet. Orphan number: ORPHA85414. ... and has been granted orphan drug designation in the European Union for the treatment of systemic juvenile idiopathic arthritis ... Givinostat for the treatment of systemic-onset juvenile idiopathic arthritis" (PDF). European Medicines Agency. Retrieved 2010- ...
"Juvenile Rheumatoid Arthritis: Benefits from Massage Theraphy". Journal of Pediatric Psychology. 22 (5): 607-617. doi:10.1093/ ... "Hand arthritis pain is reduced by massage therapy". Journal of Bodywork and Movement Therapies. 11 (1): 21-24. doi:10.1016/j. ... "The Arthritis Foundation Reveals the Multiple Benefits of a Massage - Press Release - Digital Journal". www.digitaljournal.com ... Other work demonstrated similar benefits for adults suffering arthritis pain. In research focusing on the use of alternative ...
It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque ... juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other ... Moderate to Severe Rheumatoid Arthritis (RA) (Nov 1998)[7]. *Moderate to Severe Polyarticular Juvenile Rheumatoid Arthritis ( ... "Approval of Etanercept for treatment of polyarticular course juvenile rheumatoid arthritis (JRA)" (PDF). Letter to Sally Gould ...
It was originally mistaken for juvenile rheumatoid arthritis. The bacterium involved was first described in 1981 by Willy ... Lyme arthritis usually affects the knees. In a minority of patients, arthritis can occur in other joints, including the ankles ... Arthritis and Lyme Disease Archived 4 October 2013 at the Wayback Machine., WebMD Rheumatoid Arthritis Health Center, reviewed ... 1977). "Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three connecticut communities". ...
I. Chronic musculoskeletal pain in juvenile rheumatoid arthritis". Pain. 28 (1): 27-38. doi:10.1016/0304-3959(87)91056-6. PMID ... Lequesne M (1991). "Indices of severity and disease activity for osteoarthritis". Seminars in Arthritis and Rheumatism. 20 ( ... Osteoarthritis Research Society International-Outcome Measures in Rheumatoid Arthritis Clinical Trials (OARSI-OMERACT) ...
Majeed M, Al-Mayouf SM, Al-Sabban E, Bahabri S (2000). "Coexistent linear scleroderma and juvenile systemic lupus erythematosus ... Arthritis Rheum. 50 (1): 227-32. doi:10.1002/art.11432. PMID 14730620. ... Zulian F, Athreya BH, Laxer R (2006). "Juvenile localized scleroderma: clinical and epidemiological features in 750 children. ...
ERAP1 with the enthesitis related arthritis subtype and IL23R with juvenile psoriatic arthritis". Arthritis Research & Therapy ... 173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis". Arthritis ... Colbert RA (2010). "Classification of juvenile spondyloarthritis: Enthesitis-related arthritis and beyond". Nature Reviews ... Correlate with Disease Activity in the Enthesitis-related Arthritis Category of Juvenile Idiopathic Arthritis". The Journal of ...
As a child, Horiba suffered from juvenile rheumatoid arthritis. He attended Kyoto Teachers' School's Elementary School and ...
Cerna M, Vavrincova P, Havelka S, Ivaskova E, Stastny P (1994). "Class II alleles in juvenile arthritis in Czech children". J ... DRB1*1201 is associated with iritis in juvenile arthritis, primary antiphospholipid syndrome, tiopronin intolerance in ... 1994). "A possible linkage of HLA-DRB haplotypes with Tiopronin intolerance in rheumatoid arthritis". Clin. Exp. Rheumatol. 12 ... 2007). "Human Leukocyte Antigens in Undifferentiated Spondyloarthritis". Seminars in arthritis and rheumatism. 37 (3): 198-201 ...
Zeggini, E. (2002). "Tumour necrosis factor receptor II polymorphism and juvenile idiopathic arthritis". Rheumatology. 41 (4): ... She continued her studies on the immunogenetics of the major histocompatibility complex in childhood arthritis at the Arthritis ... Zeggini, Eleftheria (2002). Genetic dissection of the major histocompatibility complex in juvenile oligoarthritis (PhD thesis ...
Forero L, Zwirner NW, Fink CW, Fernández-Viña MA, Stastny P (1998). "Juvenile arthritis, HLA-A2 and binding of DEK oncogene- ... "Antibodies to the 45 kDa DEK nuclear antigen in pauciarticular onset juvenile rheumatoid arthritis and iridocyclitis: selective ... Arthritis Rheum. 41 (8): 1505-10. doi:10.1002/1529-0131(199808)41:8. 3.0.CO;2-N. PMID 9704652. Wichmann I, Garcia-Lozano JR, ...
The model is thought to have suffered from juvenile rheumatoid arthritis. Caravaggio's sleeping Cupid was reconceived in fresco ...
It also used to treat psoriatic arthritis and juvenile idiopathic arthritis. Abatacept has not been tested in pregnant women ... Abatacept is used to treat adults with moderate to severe rheumatoid arthritis (RA) as a second line agent, and as a first line ... Abatacept was developed by Bristol-Myers Squibb and is licensed in the United States for the treatment of rheumatoid arthritis ... Abatacept (marketed as Orencia) is a drug used to treat autoimmune diseases like rheumatoid arthritis, by interfering with the ...
He was diagnosed with juvenile chronic arthritis at an early age. At the age of 15, Tom began to DJ at coffee shops in ...
For use for rheumatic fever, juvenile arthritis, Kawasaki disease "Essential medicines". World Health Organization. Retrieved ...
She suffers from juvenile chronic arthritis, and is a wheelchair user. She portrayed Alice in Richard Cameron's play Flower ...
It occurs most commonly with systemic-onset juvenile idiopathic arthritis (SoJIA). In addition, MAS has been described in ...
Juvenile diabetes, Sarcoidosis B8::DQ2 Autoimmune hepatitis, Primary biliary cirrhosis, Myasthenia gravis, Dermatitis ... Goldberg MA, Arnett FC, Bias WB, Shulman LE (1976). "Histocompatibility antigens in systemic lupus erythematosus". Arthritis ... or juvenile-onset myositis, with 4,724 control subjects. They found that multiple genes that make up AH8.1 define the genetic ...
Yokota S (2003). "Interleukin 6 as a therapeutic target in systemic-onset juvenile idiopathic arthritis". Current Opinion in ... In rheumatoid arthritis they can help patients unresponsive to TNF inhibitors. The first approved medication in this class, ... FDA Gives Nod to Sarilumab for Rheumatoid Arthritis. 2017 "UCB Announces Start Of Phase I Study For Antibody Drug Candidate ... Sarilumab was approved by US FDA in 2017 for rheumatoid arthritis. Several agents are in clinical trials: olokizumab (CDP6038) ...
Juvenile arthritis definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it ... juvenile arthritis in Medicine Expand. juvenile arthritis ju·ve·nile arthritis (jōōvə-nīl, -nəl). n. Chronic arthritis that ...
Make research projects and school reports about Juvenile arthritis easy with credible articles from our FREE, online ... and pictures about Juvenile arthritis at Encyclopedia.com. ... JUVENILE ARTHRITIS. DEFINITION. Juvenile arthritis (JA) refers ... Juvenile Arthritis. Definition. Juvenile arthritis (JA), also called juvenile rheumatoid arthritis (JRA), refers to a number of ... Juvenile arthritis. Definition. Juvenile arthritis (JA) refers to a number of different conditions, all of which strike ...
Juvenile arthritis is a general name for many types of arthritis that occur in children. Learn more from Boston Childrens ... What is juvenile arthritis?. Juvenile arthritis isnt one condition, but is the general name for many types of arthritis that ... What are the types of juvenile arthritis? Juvenile idiopathic arthritis (JIA) is the umbrella term for several subtypes of ... Septic arthritis: arthritis caused by an infection of the joint *Lupus: a chronic autoimmune condition that can have arthritis ...
Researchers now say that antibiotics increase childrens risk of developing juvenile arthritis, a painful and chronic disease ... The risk of juvenile arthritis increased with the number of courses of antibiotics prescribed. The study was conducted because ... According to scientists, juvenile arthritis can be attributed to genetics in approximately one-quarter of cases. This suggests ... Researchers now say that antibiotics increase childrens risk of developing juvenile arthritis, a painful and chronic disease. ...
... in addition to arthritis. Children with systemic juvenile idiopathic arthritis often show growth retardation and developmental ... Tocilizumab was approved for systemic juvenile idiopathic arthritis in Japan in 2008 and in the European Union and the United ... Systemic juvenile idiopathic arthritis is one of the common rheumatic diseases in childhood and characterized by spiking fever ... systemic juvenile idiopathic arthritis, tocilizumab, antihuman interleukin-6 receptor antibody, biologics ...
Get information about diagnosis and prognosis of Juvenile Arthritis, onlymyhealth.com is providing articles related to Juvenile ... Juvenile Arthritis diagnosis and prognosis - Get information about diagnosis and prognosis of Juvenile Arthritis, onlymyhealth. ... Diagnosis of juvenile arthritis may be difficult as the symptoms of arthritis can vary and some patients may have symptoms of ... There is no single test that can confirm the diagnosis of juvenile arthritis. ...
... published in the journal Pediatrics suggests that children treated with antibiotics have double the risk of developing juvenile ... arthritis compared to children who dont receive antibiotics. ... Antibiotics May Increase Childs Risk of Juvenile Arthritis. By ... The studys lead author Daniel Horton suggests that juvenile arthritis patients are more susceptible to infections as their ... Data from 450,000 children were assessed-of these, 152 children were diagnosed with juvenile arthritis. After considering ...
Check for Discount on Polyarticular Juvenile Idiopathic Arthritis (PJIA) - Pipeline Review, H1 2016 report by Global Markets ... Polyarticular Juvenile Idiopathic Arthritis (PJIA) - Recent Pipeline Updates 42. Polyarticular Juvenile Idiopathic Arthritis ( ... Polyarticular Juvenile Idiopathic Arthritis (PJIA) - Pipeline by Coherus BioSciences, Inc., H1 2016 12. Polyarticular Juvenile ... Polyarticular Juvenile Idiopathic Arthritis (PJIA) - Pipeline by Mycenax Biotech Inc., H1 2016 15. Polyarticular Juvenile ...
What Is Juvenile Arthritis?. Juvenile arthritis occurs in children 16 years of age or younger. Children with severe juvenile ... Fight Juvenile Arthritis Effectively with the Help of this Guide Juvenile arthritis can prove to be traumatic for your child. ... What Is Rheumatoid Arthritis and Juvenile Arthritis?. By Editorial Team , National Institute of Health ... What Is Rheumatoid Arthritis?. Rheumatoid arthritis is an autoimmune disease, a disorder in which the body attacks its own ...
This could be the first sign that your child has juvenile arthritis. ... All About Juvenile Arthritis. Juvenile arthritis is categorized as an idiopathic autoimmune disease. ... Please read Dealing With Juvenile Arthritis for more information on how to deal with JA and its symptoms. ... all about juvenile arthritis (JA) only affects children under the age of 16. ...
Juvenile Arthritis Research (the JAR Project). JAR is a non-profit project supported by donations, researching a cure for JIA ... Juvenile Arthritis Research is a project of the Jabez Charitable Trust (UK charity no. 1091620). This website resource provides ... Running 250 miles to find a cure for juvenile arthritis [ 31 July 2018] ... A Little Box bringing Hope to children with arthritis [11 October 2019] ...
Juvenile Arthritis. Juvenile arthritis (JA) is also known as pediatric rheumatic disease and is not a disease in itself. ... Juvenile idiopathic arthritis. These various types of JA all have their own different symptoms, but some similarities include ... The exact cause of juvenile arthritis has still not been found by researchers. Some studies suggest that the most appropriate ...
... and about one child in every 10,000 will develop severe arthritis. ... Any child can suffer from juvenile arthritis according to studies approximately one child in every 1,000 in a given year can ... develop arthritis (but most of them are mild) ... Risk factors for Juvenile Arthritis. Other Diseases By Dr ... Sex: Juvenile arthritis is more common in girls as compared to boys.. Race: The risk of juvenile arthritis appears to be higher ...
Juvenile Arthritis are autoimmune diseases. Kasturi Hospitals, Hyderabad offers cost effective treatment for your kid to enjoy ... The juvenile arthritis comes in different forms. It can be juvenile idiopathic arthritis , juvenile rheumatoid arthritis, etc. ... Juvenile arthritis management. Just like adults, children are also affected by arthritis condition. The arthritis condition in ... The diagnosis of juvenile arthritis is little difficult. Lab tests, physical exam, x-rays, MRI scan , etc are done to confirm ...
... known for treatment of all common types of pediatric arthritis. Make an appointment for juvenile arthritis care at affordable ... Proper treatment is based on the type and severity of the juvenile arthritis condition. The treatment for juvenile arthritis ... Juvenile arthritis. Overview:. Arthritis is a musculoskeletal disorder which mainly affects the joints. It can affect other ... Juvenile arthritis is a type of arthritis which develops in children. Children under the age of 16 are commonly affected. It is ...
Learn about scholarships available in SC for the annual Juvenile Arthritis conference and meet Todd Peck. ... Home > Local Offices > South Carolina > Juvenile Arthritis. Juvenile Arthritis. A Welcoming Home for Families. The Arthritis ... National Juvenile Arthritis Conference. The Arthritis Foundations annual Juvenile Arthritis Conference is where kids, teens, ... A diagnosis of juvenile arthritis can turn life upside down and make you feel powerless. The Arthritis Foundation understands ...
... (2012) by Dr Padmesh Vadakepat 17394 views * Juvenile rheumatoid arthritis by Azi YueDee 9318 ... Juvenile idiopathic arthritis by Anas Bahnassi أنس... 8801 views * Juvenile+Rheumatoid+Arthritis+slides+ by dhavalshah4424 ... arthritis Systemic juvenile rheumatoid arthritis Systemic juvenile idiopathic arthritis Other categories included Exclusion of ... Polyarticular juvenile idiopathic arthritis Psoriatic arthritis Enthesitis-related arthritis Undifferentiated arthritis Prof ...
Below you can learn about the many opportunities available in your area through the Juvenile Arthritis (JA) Program. ... The Arthritis Foundation values families who face the challenges of arthritis and related diseases. ... Home > Local Offices > Vermont > Juvenile Arthritis. Juvenile Arthritis. A Welcoming Home for Families. The Arthritis ... National Juvenile Arthritis Conference. The Arthritis Foundations annual Juvenile Arthritis Conference is where kids, teens, ...
What is Arthritis?. *Arthritis is the general term that refers to inflammation within a joint. When a joint develops arthritis ... Signs and Symptoms of Juvenile Rheumatoid Arthritis *Fatigue is a common symptom in children with JRA. Fatigue may be expressed ... Like mentioned, if the arthritis is in a leg joint, the child may limp. If the arthritis is in an arm joint, the child may have ... Arthritis affects the extremity such as arm, leg, and fingers in several ways. Any joint can be affected by JRA, but large ...
Juvenile rheumatoid arthritis begins in children younger than 16. It can be a life-long condition. Learn more about symptoms ... What is juvenile rheumatoid arthritis?. Juvenile rheumatoid arthritis is a disease. It causes joint pain and swelling. It ... Can juvenile rheumatoid arthritis be prevented or avoided?. Juvenile rheumatoid arthritis cannot be prevented or avoided. ... juvenile arthritis, juvenile rheumatoid arthritis, knuckles, osteoarthritis, puffiness, RA, rheumatic disease, rheumatoid ...
... is a term used to describe a group of disorders in children that includes arthritis. They are long-term (chronic) diseases that ... Genetic architecture distinguishes systemic juvenile idiopathic arthritis from other forms of juvenile idiopathic arthritis: ... Juvenile idiopathic arthritis (JIA) is a term used to describe a group of disorders in children that includes arthritis. They ... Juvenile idiopathic arthritis. In: Kliegman RM, St. Geme JW, Schor NF, Blum NJ, Shah SS, Tasker RC, Wilson KM, eds. Nelson ...
... rheumatologists debated the differences between rheumatoid arthritis and pediatric arthritis. A new study shows they may be ... Juvenile arthritis (JA) - also known as juvenile rheumatoid arthritis, pediatric arthritis, and juvenile idiopathic arthritis ... Are rheumatoid arthritis and juvenile rheumatoid arthritis simply the same illness diagnosed at different life stages? ... Pain, Swelling, and Stiffness: Rheumatoid Arthritis in Children. Juvenile rheumatoid arthritis (JRA) is the most common form in ...
... juvenile rheumatoid arthritis, JRA) treatment, diagnosis, prognosis, types, and causes. JRA symptoms and signs include joint ... Juvenile Idiopathic Arthritis (JIA, Arthritis in Childhood, Juvenile Rheumatoid Arthritis, JRA, Juvenile Chronic Arthritis). * ... Juvenile Idiopathic Arthritis (JIA, Arthritis in Childhood, Juvenile Rheumatoid Arthritis, JRA, Juvenile Chronic Arthritis) ... home/arthritis health center/arthritis a-z list/juvenile arthritis center/juvenile arthritis article ...
... which is also called juvenile idiopathic arthritis or JIA, is an autoimmune disease that affects children. Learn about the ... About 1 in 1,000 children develop some form of arthritis. Juvenile rheumatoid arthritis is the most common type of arthritis ... The primary difference between juvenile and adult arthritis is that juvenile arthritis sometimes disappears on its own or gets ... Juvenile psoriatic arthritis is arthritis that links to the autoimmune condition psoriasis, which causes a painful, scaly rash ...
... "juvenile arthritis". The search term "juvenile arthritis" was general enough to capture citations that referred to JCA, JRA and ... JIA or the earlier Juvenile Rheumatoid Arthritis (JRA) [2] or Juvenile Chronic Arthritis (JCA) [3] classification systems) and ... and acceptable symptom state in juvenile idiopathic arthritis: defining criteria based on the juvenile arthritis disease ... Arthritis is among the most common chronic diseases in children. Juvenile Idiopathic Arthritis (JIA) is the current ...
  • Thrombocytopenia may be observed in patients with systemic lupus erythematosus (SLE) who present with arthritis, as well as in those with marrow-occupying malignancies (eg, acute lymphocytic leukemia). (medscape.com)
  • Often categorized by daily high fevers, a salmon-colored rash and arthritis, this rare and severe form of JIA makes kids very ill. (sheknows.com)
  • Based on physical therapy evaluations, children in the JRA group were assigned to "more severe" (n = 19) and "milder" (n = 22) arthritis subgroups. (prohealth.com)
  • RESULTS: Results showed numerous differences between mothers of children with more severe arthritis and the other mothers (no differences between the milder arthritis and healthy comparison groups were found). (prohealth.com)
  • Compared to mothers in the other two groups, mothers of children with more severe arthritis were more directive of their children's behavior during the task, showing higher rates of structure and rule setting, general clues, and prompting the child for an answer. (prohealth.com)
  • 25% of cases progress to severe destructive arthritis. (wikipedia.org)
  • The impact of juvenile arthritis on a particular child may be mild moderate or severe. (washington.edu)