A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.
ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
Arthritis of children, with onset before 16 years of age. The terms juvenile rheumatoid arthritis (JRA) and juvenile idiopathic arthritis (JIA) refer to classification systems for chronic arthritis in children. Only one subtype of juvenile arthritis (polyarticular-onset, rheumatoid factor-positive) clinically resembles adult rheumatoid arthritis and is considered its childhood equivalent.
A type of inflammatory arthritis associated with PSORIASIS, often involving the axial joints and the peripheral terminal interphalangeal joints. It is characterized by the presence of HLA-B27-associated SPONDYLARTHROPATHY, and the absence of rheumatoid factor.
An aseptic, inflammatory arthritis developing secondary to a primary extra-articular infection, most typically of the GASTROINTESTINAL TRACT or UROGENITAL SYSTEM. The initiating trigger pathogens are usually SHIGELLA; SALMONELLA; YERSINIA; CAMPYLOBACTER; or CHLAMYDIA TRACHOMATIS. Reactive arthritis is strongly associated with HLA-B27 ANTIGEN.
The inner membrane of a joint capsule surrounding a freely movable joint. It is loosely attached to the external fibrous capsule and secretes SYNOVIAL FLUID.
Also known as articulations, these are points of connection between the ends of certain separate bones, or where the borders of other bones are juxtaposed.
The clear, viscous fluid secreted by the SYNOVIAL MEMBRANE. It contains mucin, albumin, fat, and mineral salts and serves to lubricate joints.
Arthritis, especially of the great toe, as a result of gout. Acute gouty arthritis often is precipitated by trauma, infection, surgery, etc. The initial attacks are usually monoarticular but later attacks are often polyarticular.
Antibodies found in adult RHEUMATOID ARTHRITIS patients that are directed against GAMMA-CHAIN IMMUNOGLOBULINS.
Inflammation of a synovial membrane. It is usually painful, particularly on motion, and is characterized by a fluctuating swelling due to effusion within a synovial sac. (Dorland, 27th ed)
A progressive, degenerative joint disease, the most common form of arthritis, especially in older persons. The disease is thought to result not from the aging process but from biochemical changes and biomechanical stresses affecting articular cartilage. In the foreign literature it is often called osteoarthrosis deformans.
A fibrillar collagen found predominantly in CARTILAGE and vitreous humor. It consists of three identical alpha1(II) chains.
An antineoplastic antimetabolite with immunosuppressant properties. It is an inhibitor of TETRAHYDROFOLATE DEHYDROGENASE and prevents the formation of tetrahydrofolate, necessary for synthesis of thymidylate, an essential component of DNA.
Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.
Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.
Measurement of rate of settling of erythrocytes in anticoagulated blood.
Methods of delivering drugs into a joint space.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Disorders of connective tissue, especially the joints and related structures, characterized by inflammation, degeneration, or metabolic derangement.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Roentgenography of a joint, usually after injection of either positive or negative contrast medium.
A subspecialty of internal medicine concerned with the study of inflammatory or degenerative processes and metabolic derangement of connective tissue structures which pertain to a variety of musculoskeletal disorders, such as arthritis.
A synovial hinge connection formed between the bones of the FEMUR; TIBIA; and PATELLA.
The articulation between a metacarpal bone and a phalanx.
A chronic inflammatory condition affecting the axial joints, such as the SACROILIAC JOINT and other intervertebral or costovertebral joints. It occurs predominantly in young males and is characterized by pain and stiffness of joints (ANKYLOSIS) with inflammation at tendon insertions.
A drug that is used in the management of inflammatory bowel diseases. Its activity is generally considered to lie in its metabolic breakdown product, 5-aminosalicylic acid (see MESALAMINE) released in the colon. (From Martindale, The Extra Pharmacopoeia, 30th ed, p907)
Peptides whose amino and carboxy ends are linked together with a peptide bond forming a circular chain. Some of them are ANTI-INFECTIVE AGENTS. Some of them are biosynthesized non-ribosomally (PEPTIDE BIOSYNTHESIS, NON-RIBOSOMAL).
Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.
Antibodies produced by a single clone of cells.
A variable mixture of the mono- and disodium salts of gold thiomalic acid used mainly for its anti-inflammatory action in the treatment of rheumatoid arthritis. It is most effective in active progressive rheumatoid arthritis and of little or no value in the presence of extensive deformities or in the treatment of other forms of arthritis.
The joint that is formed by the distal end of the RADIUS, the articular disc of the distal radioulnar joint, and the proximal row of CARPAL BONES; (SCAPHOID BONE; LUNATE BONE; triquetral bone).
Subcutaneous nodules seen in 20-30% of rheumatoid arthritis patients. They may arise anywhere on the body, but are most frequently found over the bony prominences. The nodules are characterized histologically by dense areas of fibrinoid necrosis with basophilic streaks and granules, surrounded by a palisade of cells, mainly fibroblasts and histiocytes.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
A subtype of HLA-DRB beta chains that includes over one hundred allele variants. The HLA-DRB1 subtype is associated with several of the HLA-DR SEROLOGICAL SUBTYPES.
The articulation between the head of one phalanx and the base of the one distal to it, in each finger.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
The articulations between the various TARSAL BONES. This does not include the ANKLE JOINT which consists of the articulations between the TIBIA; FIBULA; and TALUS.
An infectious disease caused by a spirochete, BORRELIA BURGDORFERI, which is transmitted chiefly by Ixodes dammini (see IXODES) and pacificus ticks in the United States and Ixodes ricinis (see IXODES) in Europe. It is a disease with early and late cutaneous manifestations plus involvement of the nervous system, heart, eye, and joints in variable combinations. The disease was formerly known as Lyme arthritis and first discovered at Old Lyme, Connecticut.
Cell surface receptors that bind TUMOR NECROSIS FACTORS and trigger changes which influence the behavior of cells.
An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.
Substances that reduce or suppress INFLAMMATION.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
Heterogeneous group of arthritic diseases sharing clinical and radiologic features. They are associated with the HLA-B27 ANTIGEN and some with a triggering infection. Most involve the axial joints in the SPINE, particularly the SACROILIAC JOINT, but can also involve asymmetric peripheral joints. Subsets include ANKYLOSING SPONDYLITIS; REACTIVE ARTHRITIS; PSORIATIC ARTHRITIS; and others.
The articulations extending from the ANKLE distally to the TOES. These include the ANKLE JOINT; TARSAL JOINTS; METATARSOPHALANGEAL JOINT; and TOE JOINT.
A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
A protective layer of firm, flexible cartilage over the articulating ends of bones. It provides a smooth surface for joint movement, protecting the ends of long bones from wear at points of contact.
The joint that is formed by the inferior articular and malleolar articular surfaces of the TIBIA; the malleolar articular surface of the FIBULA; and the medial malleolar, lateral malleolar, and superior surfaces of the TALUS.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A proinflammatory cytokine produced primarily by T-LYMPHOCYTES or their precursors. Several subtypes of interleukin-17 have been identified, each of which is a product of a unique gene.
Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.
An antigen solution emulsified in mineral oil. The complete form is made up of killed, dried mycobacteria, usually M. tuberculosis, suspended in the oil phase. It is effective in stimulating cell-mediated immunity (IMMUNITY, CELLULAR) and potentiates the production of certain IMMUNOGLOBULINS in some animals. The incomplete form does not contain mycobacteria.
The region in the hindlimb of a quadruped, corresponding to the human ANKLE.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Inflammation of the synovial lining of a tendon sheath. Causes include trauma, tendon stress, bacterial disease (gonorrhea, tuberculosis), rheumatic disease, and gout. Common sites are the hand, wrist, shoulder capsule, hip capsule, hamstring muscles, and Achilles tendon. The tendon sheaths become inflamed and painful, and accumulate fluid. Joint mobility is usually reduced.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*27 allele family.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Organic compounds that contain GOLD as an integral part of the molecule. Some are used as ANTIRHEUMATIC AGENTS. The term chrysotherapy derives from an ancient Greek term for gold.
Therapy with two or more separate preparations given for a combined effect.
The articulations extending from the WRIST distally to the FINGERS. These include the WRIST JOINT; CARPAL JOINTS; METACARPOPHALANGEAL JOINT; and FINGER JOINT.
An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA.
Determination of the degree of a physical, mental, or emotional handicap. The diagnosis is applied to legal qualification for benefits and income under disability insurance and to eligibility for Social Security and workmen's compensation benefits.
An unpleasant sensation induced by noxious stimuli which are detected by NERVE ENDINGS of NOCICEPTIVE NEURONS.
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A cytokine that stimulates the growth and differentiation of B-LYMPHOCYTES and is also a growth factor for HYBRIDOMAS and plasmacytomas. It is produced by many different cells including T-LYMPHOCYTES; MONOCYTES; and FIBROBLASTS.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
A ligand that binds to but fails to activate the INTERLEUKIN 1 RECEPTOR. It plays an inhibitory role in the regulation of INFLAMMATION and FEVER. Several isoforms of the protein exist due to multiple ALTERNATIVE SPLICING of its mRNA.
A non-vascular form of connective tissue composed of CHONDROCYTES embedded in a matrix that includes CHONDROITIN SULFATE and various types of FIBRILLAR COLLAGEN. There are three major types: HYALINE CARTILAGE; FIBROCARTILAGE; and ELASTIC CARTILAGE.
Component of the NATIONAL INSTITUTES OF HEALTH. It supports research into the causes, treatment, and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress. It was established in 1986.
Elements of limited time intervals, contributing to particular results or situations.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
A glucocorticoid with the general properties of the corticosteroids. It is the drug of choice for all conditions in which routine systemic corticosteroid therapy is indicated, except adrenal deficiency states.
3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
A specific species of bacteria, part of the BORRELIA BURGDORFERI GROUP, whose common name is Lyme disease spirochete.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73)
Infections with bacteria of the genus YERSINIA.
Pain in the joint.
Inflammation of the joints of the SPINE, the intervertebral articulations.
Process whereby the immune system reacts against the body's own tissues. Autoimmunity may produce or be caused by AUTOIMMUNE DISEASES.
Scales, questionnaires, tests, and other methods used to assess pain severity and duration in patients or experimental animals to aid in diagnosis, therapy, and physiological studies.
The articulation between the head of one phalanx and the base of the one distal to it, in each toe.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an osteoclast and is involved in CEMENTUM resorption.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
Autoantibodies directed against various nuclear antigens including DNA, RNA, histones, acidic nuclear proteins, or complexes of these molecular elements. Antinuclear antibodies are found in systemic autoimmune diseases including systemic lupus erythematosus, Sjogren's syndrome, scleroderma, polymyositis, and mixed connective tissue disease.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
A plasma protein that circulates in increased amounts during inflammation and after tissue damage.
Deformities of the hand, or a part of the hand, acquired after birth as the result of injury or disease.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Antibodies from non-human species whose protein sequences have been modified to make them nearly identical with human antibodies. If the constant region and part of the variable region are replaced, they are called humanized. If only the constant region is modified they are called chimeric. INN names for humanized antibodies end in -zumab.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Bone loss due to osteoclastic activity.
An extracellular endopeptidase of vertebrate tissues similar to MATRIX METALLOPROTEINASE 1. It digests PROTEOGLYCAN; FIBRONECTIN; COLLAGEN types III, IV, V, and IX, and activates procollagenase. (Enzyme Nomenclature, 1992)
An interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein. Proteolytic processing of the precursor form by CASPASE 1 results in release of the active form of interleukin-1beta from the membrane.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
A rare complication of rheumatoid arthritis with autoimmune NEUTROPENIA; and SPLENOMEGALY.
The distal extremity of the leg in vertebrates, consisting of the tarsus (ANKLE); METATARSUS; phalanges; and the soft tissues surrounding these bones.
A method of studying a drug or procedure in which both the subjects and investigators are kept unaware of who is actually getting which specific treatment.
The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
A double gliding joint formed by the CLAVICLE, superior and lateral parts of the manubrium sterni at the clavicular notch, and the cartilage of the first rib.
The endogenous compounds that mediate inflammation (AUTACOIDS) and related exogenous compounds including the synthetic prostaglandins (PROSTAGLANDINS, SYNTHETIC).
The articulation between a metatarsal bone (METATARSAL BONES) and a phalanx.
An oral chrysotherapeutic agent for the treatment of rheumatoid arthritis. Its exact mechanism of action is unknown, but it is believed to act via immunological mechanisms and alteration of lysosomal enzyme activity. Its efficacy is slightly less than that of injected gold salts, but it is better tolerated, and side effects which occur are potentially less serious.
Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.
A subtype of non-receptor protein tyrosine phosphatases that is characterized by the presence of an N-terminal catalytic domain and a C-terminal PROLINE-rich domain. The phosphatase subtype is predominantly expressed in LYMPHOCYTES and plays a key role in the inhibition of downstream T-LYMPHOCYTE activation. Polymorphisms in the gene that encodes this phosphatase subtype are associated with a variety of AUTOIMMUNE DISEASES.
Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
Inflammation of the SPINE. This includes both arthritic and non-arthritic conditions.
Inflammation of the bone.
A species of LENTIVIRUS, subgenus ovine-caprine lentiviruses (LENTIVIRUSES, OVINE-CAPRINE), closely related to VISNA-MAEDI VIRUS and causing acute encephalomyelitis; chronic arthritis; PNEUMONIA; MASTITIS; and GLOMERULONEPHRITIS in goats. It is transmitted mainly in the colostrum and milk.
Treatment of diseases with biological materials or biological response modifiers, such as the use of GENES; CELLS; TISSUES; organs; SERUM; VACCINES; and humoral agents.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B and OSTEOPROTEGERIN. It plays an important role in regulating OSTEOCLAST differentiation and activation.
The level of health of the individual, group, or population as subjectively assessed by the individual or by more objective measures.
Sites on an antigen that interact with specific antibodies.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Granular leukocytes having a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Methods to determine in patients the nature of a disease or disorder at its early stage of progression. Generally, early diagnosis improves PROGNOSIS and TREATMENT OUTCOME.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Subset of helper-effector T-lymphocytes which synthesize and secrete IL-17, IL-17F, and IL-22. These cytokines are involved in host defenses and tissue inflammation in autoimmune diseases.
The performance of the basic activities of self care, such as dressing, ambulation, or eating.
A thioglucose derivative used as an antirheumatic and experimentally to produce obesity in animals.
Diseases of BONES.
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
Gram-negative helical bacteria, in the genus BORRELIA, that are the etiologic agents of LYME DISEASE. The group comprises many specific species including Borrelia afzelii, Borellia garinii, and BORRELIA BURGDORFERI proper. These spirochetes are generally transmitted by several species of ixodid ticks.
Glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities.
Glycoproteins which have a very high polysaccharide content.
An encapsulated lymphatic organ through which venous blood filters.
The surgical fixation of a joint by a procedure designed to accomplish fusion of the joint surfaces by promoting the proliferation of bone cells. (Dorland, 28th ed)
The distance and direction to which a bone joint can be extended. Range of motion is a function of the condition of the joints, muscles, and connective tissues involved. Joint flexibility can be improved through appropriate MUSCLE STRETCHING EXERCISES.
Partial or total replacement of a joint.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Biologically active substances whose activities affect or play a role in the functioning of the immune system.
Combinations of diagnostic or therapeutic substances linked with specific immune substances such as IMMUNOGLOBULINS; MONOCLONAL ANTIBODIES; or ANTIGENS. Often the diagnostic or therapeutic substance is a radionuclide. These conjugates are useful tools for specific targeting of DRUGS and RADIOISOTOPES in the CHEMOTHERAPY and RADIOIMMUNOTHERAPY of certain cancers.
Prostheses used to partially or totally replace a human or animal joint. (from UMDNS, 1999)
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
In horses, cattle, and other quadrupeds, the joint between the femur and the tibia, corresponding to the human knee.
Surgical reconstruction of a joint to relieve pain or restore motion.
Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)
Tuberculosis of the bones or joints.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Distortion or disfigurement of the foot, or a part of the foot, acquired through disease or injury after birth.
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
A hinge joint connecting the FOREARM to the ARM.
A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.
The total number of cases of a given disease in a specified population at a designated time. It is differentiated from INCIDENCE, which refers to the number of new cases in the population at a given time.
Specific molecular sites on the surface of various cells, including B-lymphocytes and macrophages, that combine with IMMUNOGLOBULIN Gs. Three subclasses exist: Fc gamma RI (the CD64 antigen, a low affinity receptor), Fc gamma RII (the CD32 antigen, a high affinity receptor), and Fc gamma RIII (the CD16 antigen, a low affinity receptor).
Serum albumin from cows, commonly used in in vitro biological studies. (From Stedman, 25th ed)
The joint involving the CERVICAL ATLAS and axis bones.
PROTEOGLYCANS-associated proteins that are major components of EXTRACELLULAR MATRIX of various tissues including CARTILAGE; and INTERVERTEBRAL DISC structures. They bind COLLAGEN fibers and contain protein domains that enable oligomer formation and interaction with other extracellular matrix proteins such as CARTILAGE OLIGOMERIC MATRIX PROTEIN.
The joint that is formed by the articulation of the head of FEMUR and the ACETABULUM of the PELVIS.
A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.
Antibodies which react with the individual structural determinants (idiotopes) on the variable region of other antibodies.
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
Endoscopic examination, therapy and surgery of the joint.
Presence of calcium salts, especially calcium pyrophosphate, in the cartilaginous structures of one or more joints. When accompanied by attacks of goutlike symptoms, it is called pseudogout. (Dorland, 27th ed)
A family of zinc-dependent metalloendopeptidases that is involved in the degradation of EXTRACELLULAR MATRIX components.
A heterogeneous group of disorders, some hereditary, others acquired, characterized by abnormal structure or function of one or more of the elements of connective tissue, i.e., collagen, elastin, or the mucopolysaccharides.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
The immovable joint formed by the lateral surfaces of the SACRUM and ILIUM.
The CARPAL BONES; METACARPAL BONES; and FINGER PHALANGES. In each hand there are eight carpal bones, five metacarpal bones, and 14 phalanges.
A class of compounds composed of repeating 5-carbon units of HEMITERPENES.
Large HYALURONAN-containing proteoglycans found in articular cartilage (CARTILAGE, ARTICULAR). They form into aggregates that provide tissues with the capacity to resist high compressive and tensile forces.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
A fluid-filled sac lined with SYNOVIAL MEMBRANE that provides a cushion between bones, tendons and/or muscles around a joint.
Disease having a short and relatively severe course.

Prevention of collagen-induced arthritis by gene delivery of soluble p75 tumour necrosis factor receptor. (1/2364)

Collagen type II-induced arthritis (CIA) in DBA/1 mice can be passively transferred to SCID mice with spleen B- and T-lymphocytes. In the present study, we show that infection ex vivo of splenocytes from arthritic DBA/1 mice with a retroviral vector, containing cDNA for the soluble form of human p75 receptor of tumour necrosis factor (TNF-R) before transfer, prevents the development of arthritis, bone erosion and joint inflammation in the SCID recipients. Assessment of IgG subclass levels and studies of synovial histology suggest that down-regulating the effector functions of T helper-type 1 (Th1) cells may, at least in part, explain the inhibition of arthritis in the SCID recipients. In contrast, the transfer of splenocytes infected with mouse TNF-alpha gene construct resulted in exacerbated arthritis and enhancement of IgG2a antibody levels. Intriguingly, infection of splenocytes from arthritic DBA/1 mice with a construct for mouse IL-10 had no modulating effect on the transfer of arthritis. The data suggest that manipulation of the immune system with cytokines, or cytokine inhibitors using gene transfer protocols can be an effective approach to ameliorate arthritis.  (+info)

Modulation of acute and chronic inflammatory processes by cacospongionolide B, a novel inhibitor of human synovial phospholipase A2. (2/2364)

1. Cacospongionolide B is a novel marine metabolite isolated from the sponge Fasciospongia cavernosa. In in vitro studies, this compound inhibited phospholipase A2 (PLA2), showing selectivity for secretory PLA2 (sPLA2) versus cytosolic PLA2 (cPLA2), and its potency on the human synovial enzyme (group II) was similar to that of manoalide. 2. This activity was confirmed in vivo in the 8 h zymosan-injected rat air pouch, on the secretory enzyme accumulating in the pouch exudate. Cacospongionolide B, that is bioavailable when is given orally, reduced the elevated levels of sPLA2 present in paw homogenates of rats with adjuvant arthritis. 3. This marine metabolite showed topical anti-inflammatory activity on the mouse ear oedema induced by 12-O-tetradecanoylphorbol acetate (TPA) and decreased carrageenin paw oedema in mice after oral administration of 5, 10 or 20 mg kg(-1). 4. In the mouse air pouch injected with zymosan, cacospongionolide B administered into the pouch, induced a dose-dependent reduction in the levels of eicosanoids and tumour necrosis factor alpha (TNFalpha) in the exudates 4 h after the stimulus. It also had a weak effect on cell migration. 5. The inflammatory response of adjuvant arthritis was reduced by cacospongionolide B, which did not significantly affect eicosanoid levels in serum, paw or stomach homogenates and did not induce toxic effects. 6 Cacospongionolide B is a new inhibitor of sPLA2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation. This marine metabolite was active after oral administration and able to modify TNFalpha levels, and may offer an interesting approach in the search for new anti-inflammatory agents.  (+info)

Localization of non-Mhc collagen-induced arthritis susceptibility loci in DBA/1j mice. (3/2364)

One approach to understanding common human diseases is to determine the genetic defects responsible for similar diseases in animal models and place those defective genes in their corresponding biochemical pathways. Our laboratory is working with an animal model for human rheumatoid arthritis called collagen-induced arthritis (CIA). We are particularly interested in determining the location of disease-predisposing loci. To that end, we performed experiments to localize susceptibility loci for CIA in an F2 cross between the highly susceptible mouse strain DBA/1j and the highly resistant mouse strain SWR/j. Specifically, a quantitative trait locus analysis was performed to localize regions of the mouse genome responsible for susceptibility/severity to CIA. One susceptibility locus, Cia1 in the major histocompatibility locus, had been identified previously. Two additional loci were detected in our analysis that contribute to CIA severity (Cia2, Cia3) on chromosomes 2 and 6. A third locus was detected that contributes to the age of onset of the disease. This locus (Cia4) was located on chromosome 2 and was linked to the same region as Cia2. Determining the identity of these loci may provide insights into the etiology of human rheumatoid arthritis.  (+info)

Effects of petrosaspongiolide M, a novel phospholipase A2 inhibitor, on acute and chronic inflammation. (4/2364)

The marine product petrosaspongiolide M is a novel inhibitor of phospholipase A2 (PLA2), showing selectivity for secretory PLA2 versus cytosolic PLA2, with a potency on the human synovial enzyme (group II) similar to that of manoalide. This compound was more potent than manoalide on bee venom PLA2 (group III) and had no effect on group I enzymes (Naja naja and porcine pancreatic PLA2). Inhibition of PLA2 was also observed in vivo in the zymosan-injected rat air pouch, on the secretory enzyme accumulated in the pouch exudate. Petrosaspongiolide M decreased carrageenan paw edema in mice after the oral administration of 5, 10, or 20 mg/kg. This marine metabolite (0.01-1.0 micromol/pouch) induced a dose-dependent reduction in the levels of prostaglandin (PG)E2, leukotriene B4, and tumor necrosis factor-alpha in the mouse air pouch injected with zymosan 4 h after the stimulus. It also had a weaker effect on cell migration. The inflammatory response of adjuvant arthritis was reduced by petrosaspongiolide M, which also inhibited leukotriene B4 levels in serum and PGE2 levels in paw homogenates. In contrast with indomethacin, this marine compound did not reduce PGE2 levels in stomach homogenates. Petrosaspongiolide M is a new inhibitor of secretory PLA2 in vitro and in vivo, with anti-inflammatory properties in acute and chronic inflammation.  (+info)

Efficacy of sustained blood levels of interleukin-1 receptor antagonist in animal models of arthritis: comparison of efficacy in animal models with human clinical data. (5/2364)

OBJECTIVE: To determine the role of interleukin-1 receptor antagonist (IL-1Ra) in rat adjuvant arthritis and rat type II collagen-induced arthritis, and to compare the efficacy in rat models with that seen in human clinical trials of IL-1Ra. METHODS: Rats with developing adjuvant arthritis or established collagen-induced arthritis were treated with IL-1Ra by continuous infusion in order to determine and maintain efficacious blood levels of this IL-1 inhibitory protein in the rats for comparison with human clinical data. The effects of treatment in the rats were monitored by sequential caliper measurement of the ankle joints, determination of final paw weights, and histologic evaluation with particular emphasis on bone and cartilage lesions. The effects of IL-1Ra on joint swelling and radiographic bone damage in patients with rheumatoid arthritis (RA) in a 6-month trial were compared with the findings in rats. RESULTS: Dramatic differences in the profile of IL-1Ra activity were seen between the 2 groups of rats. Modest antiinflammatory effects were observed in the adjuvant arthritis rats treated with IL-1Ra. However, marked inhibition of bone resorption occurred, even at doses with which antiinflammatory activity was not seen. In contrast, IL-1Ra treatment of rats with established collagen-induced arthritis resulted in nearly complete suppression of all aspects of the disease when adequate blood levels of IL-1Ra were maintained. Treatment of RA patients with IL-1Ra (150 mg daily) resulted in modest inhibition of joint swelling and inhibition of radiographic progression of bone lesions. CONCLUSION: IL-1 appears to be of major importance in mediating the bone resorption that occurs in rat adjuvant arthritis, but is less important in the pathogenesis of periarticular inflammation in this disease. In contrast, IL-1 is of major importance in mediating all aspects of disease progression in rat collagen-induced arthritis. Similar to the response in adjuvant arthritic rats, RA patients treated with IL-1Ra showed only modest antiinflammatory activity, but had evidence of inhibition of progression of bone resorption. However, a comparison of the plasma levels of IL-1Ra in humans and rats suggests that the optimal level of dosing for continuous saturation of IL-1 receptors may not have been achieved in humans, although this was achieved in the rat studies.  (+info)

Somatostatin receptor subtype expression in cells of the rat immune system during adjuvant arthritis. (6/2364)

Somatostatin is a neuropeptide that is widely distributed throughout the body. It acts as a neurohormone and a neurotransmitter and may also have an immunomodulatory role. The genes for five subtypes of somatostatin receptors (sst) have been cloned, suggesting that the diverse effects of the peptide might be mediated by different receptors. We are interested in studying the role of sst ininflammation, using an animal model. Because of the up-regulation of sst expression in inflamed joints in human rheumatoid arthritis, we chose rat adjuvant arthritis as an experimental model. In order to determine which of the sst subtypes might be important in immune modulation, subtype expression in leukocytes isolated from different lymphoid tissues of the rat was studied. Also, the expression levels of the most abundantly expressed sst mRNAs in leukocytes from spleen and blood were compared in rats with adjuvantarthritis and controls, using a semi-quantitative approach. Furthermore, the effect of systemic administration of a long-acting somatostatin analogue, octreotide, which binds selectively to sst subtypes 2 and 5 (sst2 and sst5), on the incidence and the severity of rat adjuvant arthritis, was studied. The main sst expressed in cells of the rat immune system, both resting and activated, were found to be sst3 and sst4. This contrasts with the human and murine situations, in which sst2 appears to be the main subtype expressed in the immune system. No quantitative differences in sst subtype mRNA levels in leukocytes from spleen and blood were found between rats with adjuvant arthritis and controls. Finally, no effect of systemic administration of octreotide on either the incidence or severity of adjuvant arthritis in Lewis rats was found. As octreotide binds selectively to sst2 and sst5, the absence of an immunomodulatory effect of this analogue in rat adjuvant arthritis corroborates our finding that these sst subtypes are not expressed in cells of the rat immune system. In conclusion, cells of the rat immune system appear to express a spectrum of sst (sst3 and sst4) different from that found in human granulomatous and autoimmune disease (mainly sst2). Therefore, the rat adjuvant arthritis model appears to be suitable only for studying the immunomodulatory effects of somatostatin analogues which have a high affinity for sst3 and sst4, but not for studying the immunomodulatory effects of octreotide, which has a high affinity only for sst2 and sst5.  (+info)

Prevention of collagen-induced arthritis in mice by a polyphenolic fraction from green tea. (7/2364)

Identification of common dietary substances capable of affording protection or modulating the onset and severity of arthritis may have important human health implications. An antioxidant-rich polyphenolic fraction isolated from green tea (green tea polyphenols, GTPs) has been shown to possess anti-inflammatory and anticarcinogenic properties in experimental animals. In this study we determined the effect of oral consumption of GTP on collagen-induced arthritis in mice. In three independent experiments mice given GTP in water exhibited significantly reduced incidence of arthritis (33% to 50%) as compared with mice not given GTP in water (84% to 100%). The arthritis index also was significantly lower in GTP-fed animals. Western blot analysis showed a marked reduction in the expression of inflammatory mediators such as cyclooxygenase 2, IFN-gamma, and tumor necrosis factor alpha in arthritic joints of GTP-fed mice. Histologic and immunohistochemical analysis of the arthritic joints in GTP-fed mice demonstrated only marginal joint infiltration by IFN-gamma and tumor necrosis factor alpha-producing cells as opposed to massive cellular infiltration and fully developed pannus in arthritic joints of non-GTP-fed mice. The neutral endopeptidase activity was approximately 7-fold higher in arthritic joints of non-GTP-fed mice in comparison to nonarthritic joints of unimmunized mice whereas it was only 2-fold higher in the arthritic joints of GTP-fed mice. Additionally, total IgG and type II collagen-specific IgG levels were lower in serum and arthritic joints of GTP-fed mice. Taken together our studies suggest that a polyphenolic fraction from green tea that is rich in antioxidants may be useful in the prevention of onset and severity of arthritis.  (+info)

Specific targeting of activated endothelium in rat adjuvant arthritis with a 99mTc-radiolabeled E-selectin-binding peptide. (8/2364)

OBJECTIVE: To determine the potential of an E-selectin-binding peptide (ESbp) to specifically bind activated endothelium in rheumatoid arthritis (RA) animal models. METHODS: ESbp (KYDGDITWDQLWDLMK; 2,027 daltons) was labeled with biotin and 99mTc. The affinity of ESbp derivatives for E-selectin was measured by enzyme-linked immunosorbent assay. The binding of biotin-ESbp was compared with that of an anti-E-selectin antibody, by immunohistochemical analyses of human synovial sections and sections from the Mycoplasma pulmonis MRL-lpr/lpr mouse arthritis model. 99mTc-ESbp was sequentially imaged in vivo with a gamma camera in the rat adjuvant-induced arthritis model. RESULTS: E-selectin expression was detected in human RA synovium and mouse arthritic synovium using biotin-ESbp. Both biotin-ESbp and 99mTc-labeled ESbp had high affinity for E-selectin (dissociation constant 2-5 nM). In vivo imaging showed specific binding of 99mTc-ESbp to the rat ankle joint prior to clinical manifestations of inflammation. CONCLUSION: These results demonstrate that activated endothelium can be targeted with 99mTc-ESbp. The specificity of targeting can be used to evaluate up-regulation of E-selectin in RA models, and to follow changes in this up-regulation during treatment trials.  (+info)

The purpose of this study was to investigate the lesions of a mouse collagen antibody-induced arthritis (CAIA) model using fluorescence bioimaging and micro-computed tomography (micro-CT) and to compare it with histopathological examination. Twelve mice were randomly divided into three groups: group 1 (G1) as control, group 2 (G2) as fluorescence probe control and group 3 (G3) as collagen antibody-induced arthritis. The mice of G3 intravenously received anti-type II collagen 5-clone antibody cocktail (2 mg/mouse) on day 0 and intraperitoneally received lipopolysaccharide (|TEX|$50{\mu}g/mouse$|/TEX|) on day 3. On the while, the mice of G1 and G2 received 0.9% saline in equal volumes at equivalent times. Fluorescence bioimaging and micro-CT analysis were carried out to assess arthritis. Treatment with the collagen antibody cocktail increased the paw thickness of mice compared to those in both the control and probe-treated groups. Fluorescence bioimaging using a near infrared imaging agent showed high
Les Produits de Chondrex Modèles animaux Anticorps Tests danticorps Recherche sur les bactéries Recherche contre le cancer Collagène Collagénase HMGB1 Dosages de protéines Coloration des tissus Tampons dimmunoanalyse Métabolisme cellulaire Les MSDS ou fiches de données de sécurités Protocoles Gentaur Assay kits en collaboration Animal Model Protocols Arthritis Scoring System Collagen Antibody-Induced Arthritis - Mouse (cat# 53010, 53040, 53100) Collagen-Induced Arthritis - Mouse Collagen-Induced Arthritis - Mouse (Visual Guide) Collagen-Induced Arthritis - Rat Adjuvant-Induced Arthritis - […]. ...
Studies in IL-6-deficient (IL-6-/-) mice highlight that IL-6 contributes to arthritis progression. However, the molecular mechanism controlling its activity in vivo remains unclear. Using an experimental arthritis model in IL-6-/- mice, we have established a critical role for the soluble IL-6R in joint inflammation. Although intra-articular administration of IL-6 itself was insufficient to reconstitute arthritis within these mice, a soluble IL-6R-IL-6 fusion protein (HYPER-IL-6) restored disease activity. Histopathological assessment of joint sections demonstrated that HYPER-IL-6 increased arthritis severity and controlled intrasynovial mononuclear leukocyte recruitment through the CC-chemokine CCL2. Activation of synovial fibroblasts by soluble IL-6R and IL-6 emphasized that these cells may represent the source of CCL2 in vivo. Specific blockade of soluble IL-6R signaling in wild-type mice using soluble gp130 ameliorated disease. Consequently, soluble IL-6R-mediated signaling represents a ...
The Rho family GTPase Rac1 regulates cytoskeletal rearrangements crucial for the recruitment, extravasation and activation of leukocytes at sites of inflammation. Rac1 signaling also promotes the activation and survival of lymphocytes and osteoclasts. Therefore, we assessed the ability of a cell-permeable Rac1 carboxy-terminal inhibitory peptide to modulate disease in mice with collagen-induced arthritis (CIA). CIA was induced in DBA/1 mice, and in either early or chronic disease, mice were treated three times per week by intraperitoneal injection with control peptide or Rac1 inhibitory peptide. Effects on disease progression were assessed by measurement of paw swelling. Inflammation and joint destruction were examined by histology and radiology. Serum levels of anti-collagen type II antibodies were measured by enzyme-linked immunosorbent assay. T-cell phenotypes and activation were assessed by fluorescence-activated cell sorting analysis. Results were analyzed using Mann-Whitney U and unpaired Student
Methods Expression levels of Mincle mRNA was determined in inflamed paws from hTNFtg and IL1-/-IL6-/-hTNFtg mice by qPCR. To study the role of mincle deficiency in experimental arthritis, we generated mincle-/-hTNFtg mice as well as their hTNFtg littermates. Mice were weekly assessed for clinical signs of arthritis from week 4 to 11 after birth. We quantitatively analysed inflammatory joint destruction in H&E, TRAP and TB stained sections from hind paws. The effect of mincledeficiency was also evaluated in the K/BxN serum transfer model. Therefore, mincle-/- and mincle+/+ mice received i.v. injections of K/BxN serum on day 1 and day 3. Animals were assessed from day1 to 12 for clinical signs of arthritis. Quantitative histopathological analysis were performed as above mentioned in hind paws.. ...
TY - JOUR. T1 - Inhibition of Notch signalling ameliorates experimental inflammatory arthritis. AU - Park, Jong Sung. AU - Kim, Seol Hee. AU - Kim, Kwang Meyung. AU - Jin, Cheng Hao. AU - Choi, Ki Young. AU - Jang, Jiyeon. AU - Choi, Yuri. AU - Gwon, A. Ryeong. AU - Baik, Sang Ha. AU - Yun, Ui Jeong. AU - Chae, Su Young. AU - Lee, Seulki. AU - Kang, Young Mo. AU - Lee, Kang Choon. AU - Arumugam, Thiruma V.. AU - Mattson, Mark P.. AU - Park, Jae Hyung. AU - Jo, Dong Gyu. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Objective: To test the hypothesis that Notch signalling plays a role in the pathogenesis of rheumatoid arthritis (RA) and to determine whether pharmacological inhibition of Notch signalling with γ-secretase inhibitors can ameliorate the RA disease process in an animal model.Methods Collagen-induced arthritis was induced in C57BL/6 or Notch antisense transgenic mice by immunisation with chicken type II collagen (CII). C57BL/6 mice were administered with different doses of inhibitors of ...
The use of regulatory or immature dendritic cells (DCs) as tools for modulating experimental rheumatoid arthritis is very recent. TNF-stimulated DCs have been shown to restore tolerance in experimental autoimmune encephalomyelitis and collagen-induced arthritis (CIA).. Objective: We investigated the capacity of short-term lipopolysaccharide (LPS)-stimulated DCs pulsed with type-II collagen (CII) to induce tolerance against established CIA.. Methods: Bone marrow-derived DCs were generated in the presence of GM-CSF. After CIA induction, mice were injected at day 35 with a single dose of 4- or 24-hour LPS-stimulated DCs that had been loaded with CII (CII/DCs, 4hLPS/CII/DCs or 24hLPS/CII/DCs). Arthritis progression was monitored by clinical and histologic evaluations.. Results Flow cytometry of 4hLPS/CII/DCs showed intermediate CD40 and CD86 expression, lower than that of 24hLPS/CII/DCs (fully mature) and higher than that of CII/DCs (immature). A functional assay showed that 4hLPS/CII/DCs display ...
Experimental Arthritis: ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include injections of stimulators of the immune response, such as an adjuvant (ADJUVANTS, IMMUNOLOGIC) or COLLAGEN.
Most antirheumatic therapies are given systemically, which may result in complications because of the high dosage needed to achieve therapeutic levels in the joints. Gene therapy might provide a more efficient system to deliver therapeutic compounds at the site of inflammation. The artificial chromosome expression system (ACes) is a unique, nonintegrating, nonviral gene-expression system, which functions like a natural chromosome. This technology offers advantages over current expression systems because it allows stable expression of genes producing single or multiple proteins over long periods. We are developing ex vivo gene therapy using artificial chromosomes containing reporter genes (LacZ or RFP) for local delivery of genes in rats with adjuvant arthritis. The aim of this study was to evaluate the transfection efficiency in cell lines or primary cells, including rat skin fibroblasts (RSFs) and fibroblast-like synoviocytes (FLSs). Furthermore, we investigated the feasibility of local ...
There is considerable evidence implicating tumor necrosis factor alpha (TNF-alpha) in the pathogenesis of rheumatoid arthritis. This evidence is based not only on the universal presence of TNF-alpha in arthritic joints accompanied by the upregulation of TNF-alpha receptors but also on the effects of neutralizing TNF-alpha in joint cell cultures. Thus, neutralization of TNF-alpha in vitro results in inhibition of the production of interleukin 1, which like TNF-alpha, is believed to contribute to joint inflammation and erosion. To determine the validity of this concept in vivo, the effect of administering TNF-neutralizing antibodies to mice with collagen-induced arthritis has been studied. This disease model was chosen because of its many immunological and pathological similarities to human rheumatoid arthritis. TN3-19.12, a hamster IgG1 monoclonal antibody to murine TNF-alpha/beta, was injected i.p. into mice either before the onset of arthritis or after the establishment of clinical disease. Anti-TNF
It has been demonstrated that pterostilbene inhibits reactive oxygen species production in neutrophils in vitro. However, little is known about its effects on neutrophils during inflammation in vivo. In this study, the effect of pterostilbene on neutrophil activity was investigated in experimental arthritis model. Lewis rats were injected by a single intradermal injection of heat-killed Mycobacterium butyricum in Freunds adjuvant to develop arthritis. Another group of arthritic animals received pterostilbene 30mg/kg, daily, p.o. The number and activity of neutrophils in blood were measured on a weekly basis during the whole experiment. Moreover, the total radical trapping potential in plasma was measured at the end of the experiment. In the pterostilbene treated arthritic group, the treatment significantly lowered the number of neutrophils in blood on days 14 and 21 without significant downregulation of neutrophil oxidative burst. Pterostilbene nonsignificantly increased total radical trapping ...
A rapid and synchronized alternative to the CIA and K/BxN models that reduces variability, eliminates the need for expensive colonies and conserves test compound, controls and vivarium space.
Incidence and severity of K/BxN serum transfer-induced arthritis are not reduced in IL-36 receptor (R) knockout (KO) mice. Incidence of arthritis (A), arthritis
Fingerprint Dive into the research topics of Transforming growth factor β-transduced mesenchymal stem cells ameliorate experimental autoimmune arthritis through reciprocal regulation of Treg/Th17 cells and osteoclastogenesis. Together they form a unique fingerprint. ...
DIAS, Renata Gonçalves; SAMPAIO, Sandra Coccuzzo; SANTANNA, Morena Brazil; et al. Articular inflammation induced by an enzymatically-inactive Lys49 phospholipase A2: activation of endogenous phospholipases contributes to the pronociceptive effect. Journal of Venomous Animals and Toxins including Tropical Diseases, London, v. 23, p. 13 , 2017. Disponível em: < http://dx.doi.org/10.1186/s40409-017-0104-0 > DOI: 10.1186/s40409-017-0104-0 ...
In humans and in animal models, susceptibility to arthritis is under complex genetic control, reflecting influences on the immunological processes that initiate autoimmunity and on subsequent inflammatory mechanisms in the joints. The effector phases are conveniently modeled by the K/BxN serum transfer system, a robust model well suited for genetic analysis where arthritis is initiated by pathogenic Ig. Here, we mapped the genetic loci distinguishing the high-responder BALB/c vs. low-responder SJL strains. After computational modeling of potential breeding schemes, we adapted a stepwise selective breeding strategy, with a whole-genome scan performed on a limited number of animals. Several genomic regions proved significantly associated with high sensitivity to arthritis. One of these regions, on distal chr2, was centered on the interleukin 1 gene family. Quantitation of transcripts of the Il1a and Il1b candidate genes revealed a 10-fold greater induction of Il1b mRNA in BALB/c than in SJL
The DNA binding activity of AP-1 and NF-kappaB are markedly increased in both CIA and RA. In CIA, activation of AP-1 and NF-kappaB precede both clinical arthritis and metalloproteinase gene expression. NF-kappaB expression correlated better than AP-1 with metalloproteinase expression.
Second, in order to investigate whether other MHC genes also contribute to arthritis susceptibility, we assessed arthritis development in congenic strains mapped to other parts of the MHC region. We identified a second arthritis-regulatory QTL in the MHC class III region, that regulates not only the onset and severity, but also chronicity of arthritis. We subsequently mapped this effect to a conserved, 33-kb large haplotype Ltab-Ncr3 comprising five polymorphic genes. Interestingly, unlike other positionally-identified arthritis genes in rats, Ltab-Ncr3 regulates only adjuvant arthritis models but not autoimmunity triggered by specific tissue antigens, such as type II collagen. Furthermore, we found that gene expression and alternative splicing of the Ltab-Ncr3 genes correlate remarkably with arthritis severity and some of the gene expression differences were reproduced in a cohort of RA patients and healthy controls ...
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Peptide analogues of disease-associated epitopes were studied for inhibition of experimental allergic encephalomyelitis (EAE) and adjuvant arthritis (AA) in Lewis rats. EAE- and AA-associated analogues were selected as competitors because of their in vitro inhibitory activity on proliferation of encephalitogenic and arthritogenic T cells. Although the EAE-associated competitor had a superior major histocompatibility complex (MHC) binding affinity, the AA-associated competitor was a better inhibitor of the in vitro proliferation of arthritogenic T cells. Furthermore, although in vivo EAE was inhibited by both competitors, AA was only inhibited by the AA-associated competitor. Remarkably, in contrast to what was expected of a regular MHC competitor peptide, the AA-associated peptide analogue also prevented AA upon immunization before disease induction and appeared to induce T cell responses that crossreacted with the original disease-associated epitope. Therefore, it is concluded that ...
In collagen-induced arthritis (CIA) of mouse, self-reactive T cells recognize a peptide antigen from type II collagen (CII). CII is of particular interest, as an autoimmune response to this protein leads to CIA in mice, rats, and primates. Activation of T cells is believed to be an important pathogenic factor in autoimmune disease. So, T cells have become a focal point of study for the development of novel therapeutic approaches to the treatment of autoimmune disease. In this study, we evaluated the efficacy and mechanism of recombinant MHC II molecules in regulation of the antigen-specific T cell clones by using mouse I-Aq, combined with an auto-antigen peptide from type II collagen (CII260-274) in CIA model. It was found that recombinant I-Aq/CII260-274 molecules not only activate CII-specific T cell clone but also inhibit the same clone in vitro according to the condition of stimulation. Furthermore, development of CIA in mice was successfully prevented by the in vivo injection of a ...
Celastrol exhibits anti-arthritic effect in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca mobilization in treatment of RA remains unelucidated. Here, we illustrate the regulatory role of celastrol-induced Ca signalling in synovial fibroblasts of RA patients and adjuvant-induced arthritis (AIA) in rats. Molecular target of celastrol was determined by computational docking, Ca dynamic and functional assays on SERCA. Ca -mediated autophagy in RASFs/RAFLS and the underlying mechanism were verified by quantification of endogenous LC3-II puncta, immunoblotting, and flow cytometry with the Ca chelator (BAPTA/AM) or suitable inhibitors. The anti-arthritic effect of celastrol, autophagy induction and growth rate of synovial fibroblasts in AIA rats were monitored by microCT and immunofluorescence staining. mRNA from joint tissues of AIA rats was isolated for transcriptional analysis of inflammatory genes. The role of Ca in regulating the identified genes was investigated by knockdown of ...
Celastrol exhibits anti-arthritic effect in rheumatoid arthritis (RA), but the role of celastrol-mediated Ca mobilization in treatment of RA remains unelucidated. Here, we illustrate the regulatory role of celastrol-induced Ca signalling in synovial fibroblasts of RA patients and adjuvant-induced arthritis (AIA) in rats. Molecular target of celastrol was determined by computational docking, Ca dynamic and functional assays on SERCA. Ca -mediated autophagy in RASFs/RAFLS and the underlying mechanism were verified by quantification of endogenous LC3-II puncta, immunoblotting, and flow cytometry with the Ca chelator (BAPTA/AM) or suitable inhibitors. The anti-arthritic effect of celastrol, autophagy induction and growth rate of synovial fibroblasts in AIA rats were monitored by microCT and immunofluorescence staining. mRNA from joint tissues of AIA rats was isolated for transcriptional analysis of inflammatory genes. The role of Ca in regulating the identified genes was investigated by knockdown of ...
Abs to the α-chain of the IL-2 receptor (anti-CD25) are used clinically to achieve immunosuppression. Here we investigated the effects of DNA vaccination with the whole CD25 gene on the induction of rat adjuvant arthritis. The DNA vaccine protected the rats and led to a shift in the cytokine profile of T cells responding to disease target antigens from Th1 to Th2. The mechanism of protection was found to involve the induction of an antiergotypic response, rather than the induction of anti-CD25 Abs. Antiergotypic T cells respond to activation molecules, ergotopes, expressed on syngeneic activated, but not resting, T cells. CD25-derived peptides function as ergotopes that can be recognized by the antiergotypic T cells. Antiergotypic T cells taken from control sick rats did not proliferate against activated T cells and secreted mainly IFN-γ. In contrast, antiergotypic cells from CD25-DNA-protected rats proliferated against activated T cells and secreted mainly IL-10. Protective antiergotypic T ...
Animals, Antibodies; Monoclonal/pharmacology, Antigen-Antibody Complex/immunology, Arthritis; Experimental/genetics/*immunology, Collagen Type II/immunology, Comparative Study, Genetic Predisposition to Disease, Immunoglobulin G/*metabolism, Macrophages; Peritoneal/*immunology, Mice, Mice; Mutant Strains, Receptors; IgG/antagonists & inhibitors/genetics/*metabolism, Research Support; Non-U.S. Govt ...
Rhomboid family member 2 gene (Rhbdf2) is an inactive homologue lacking essential catalytic residues of rhomboid intramembrane serine proteases. The protein is necessary for maturation of tumor necrosis factor-alpha (TNF-α) converting enzyme, which is the molecule responsible for the release of TNF-α. In this study, Rhbdf2 knockout (KO) mice were produced by CRISPR/CAS9. To see the effects of the failure of TNF-α release induced by Rhbdf2 gene KO, collagen-induced arthritis (CIA), which is the representative TNF-α related disease, was induced in the Rhbdf2 mutant mouse using chicken collagen type II. The severity of the CIA was measured by traditional clinical scores and histopathological analysis of hind limb joints. A rota-rod test and grip strength test were employed to evaluate the severity of CIA based on losses of physical functions. The results indicated that Rhbdf2 mutant mice showed clear alleviation of the clinical severity of CIA as demonstrated by the significantly lower severity ...
A risk score encompassing clinical characteristics, serologic findings, and imaging tests could be used to predict which antibody-positive patients are likely to go on to develop rheumatoid arthritis,
Destruction of cartilage and bone is a poorly managed hallmark of human rheumatoid arthritis (RA). p38 Mitogen-activated protein kinase (MAPK) has been shown to regulate key proinflammatory pathways in RA, including tumor necrosis factor α, interleukin (IL)-1β, and cyclooxygenase-2, as well as the process of osteoclast differentiation. Therefore, we evaluated whether a p38α MAPK inhibitor, indole-5-carboxamide (SD-282), could modulate cartilage and bone destruction in a mouse model of RA induced with bovine type II collagen [collagen-induced arthritis (CIA)]. In mice with early disease, SD-282 treatment significantly improved clinical severity scores, reduced bone and cartilage loss, and reduced mRNA levels of proinflammatory genes in paw tissue, including IL-1β, IL-6, and cyclooxygenase-2. Notably, SD-282 treatment of mice with advanced disease resulted in significant improvement in clinical severity scoring and paw swelling, a reversal in bone and cartilage destruction as assessed by ...
Mediators of Inflammation is a peer-reviewed, Open Access journal that publishes original research and review articles on all types of inflammatory mediators, including cytokines, histamine, bradykinin, prostaglandins, leukotrienes, PAF, biological response modifiers and the family of cell adhesion-promoting molecules.
These findings raise the important question of why TNFα blockade is effective in reducing disease activity despite increasing numbers of Th1 and Th17 cells. To address this question, we used an adoptive transfer system established previously (15) to confirm that the expanded Th1/Th17 cells were potentially pathogenic. Spleen and LN cells from arthritic mice treated for 10-14 d with anti-TNFα mAb or control Ab were pooled and injected into CB-17 SCID mice (5 × 107 cells/mouse or 107 cells/mouse). The SCID recipients were also injected i.p. with 100 μg of type II collagen without adjuvant, which is required for the successful transfer of arthritis (15). The proportion of LN cells to spleen cells was ∼1:10 and was identical in both anti-TNFα-treated and control groups.. Transfer of 5 × 107 cells from either anti-TNFα-treated or control mice led to efficient transfer of arthritis, although onset of arthritis was much earlier when donor cells were derived from anti-TNFα-treated mice (Fig. ...
Find anti inflammatory antiarthritic effects. Mississsippi Stem Cell Therapy Center promotes stem cell therapy and regenerative medicine.
Immune and inflammatory systems are controlled by multiple cytokines, including ILs and INFs. These cytokines exert their biological functions through Janus tyrosine kinases and STAT transcription factors. One such cytokine, IL-6, has been proposed to contribute to the development of rheumatoid arthritis (RA). We found that STAT3 was strongly tyrosine phosphorylated in synovial tissue of RA patients, but not those with osteoarthritis. Blockade of the IL-6-gp130-JAK-STAT3-signaling pathway might therefore be beneficial in the treatment of RA. We show here that the mRNA for the endogenous cytokine signaling repressor CIS3/SOCS3 is abundantly expressed in RA patients. To determine whether CIS3 is effective in treating experimental arthritis, a recombinant adenovirus carrying the CIS3 cDNA was injected periarticularly into the ankle joints of mice with antigen-induced arthritis or collagen-induced arthritis (CIA). Periarticular injection of CIS3 adenovirus drastically reduced the severity of ...
The 60 kDa heat shock protein (HSP60) has been reported to influence T-cell responses in two ways: as a ligand of toll-like receptor 2 signalling and as an antigen. Here we describe a new mechanism of T-cell immuno-regulation focused on HSP60: HSP60 is up-regulated and presented by activated T cells (HSP60 is an ergotope) to regulatory (anti-ergotypic) T cells. Presentation of HSP60 by activated T cells was found to be MHC-restricted and dependent on accessory molecules - CD28, CD80 and CD86. Anti-ergotypic T cells responded to T-cell HSP60 by proliferation and secreted IFNγ and TGFβ1. In vitro, the anti-ergotypic T cells inhibited IFNγ production by their activated T-cell targets. In vivo, adoptive transfer of an anti-ergotypic HSP60-specific T-cell line led to decreased secretion of IFNγ by arthritogenic T cells and ameliorated adjuvant arthritis (AA). Thus, the presentation of HSP60 by activated T cells turns them into targets for anti-ergotypic regulatory T cells specific for HSP60. ...
(a)-(c) Typical histological appearance of CIA mouse paws: (a) severe inflammatory cellular infiltration-synovitis and pannus formation; (b) bone and cartil
Aggravation of Cold-Restraint Stress-Induced Gastric Lesions in Adjuvant Arthritic Rats : Pathogenic Role of Inducible and Endothelial Nitric Oxide (2009 ...
BioAssay record AID 184149 submitted by ChEMBL: Inhibition of streptococcal cell wall-washed arthritis model in rats at 30.0 mg/kg peroral dose.
Rheumatoid arthritis (RA) is characterized by progressive inflammation of the synovial joints that leads to the breakdown of cartilage and bone …
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TY - JOUR. T1 - Effective treatment of established murine collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express IL-4. AU - Kim, S. H.. AU - Kim, S.. AU - Evans, C. H.. AU - Ghivizzani, S. C.. AU - Oligino, T.. AU - Robbins, P. D.. N1 - Copyright: Copyright 2017 Elsevier B.V., All rights reserved.. PY - 2001/3/1. Y1 - 2001/3/1. N2 - Dendritic cells (DC) are APCs that are able to stimulate or inhibit immune responses, depending on levels of expression of MHC class I and II costimulatory molecules and cytokines. Our previous studies have suggested that the observed contralateral effect, where injection of a vector carrying certain immunomodulatory genes into one joint resulted in inhibition of arthritis in untreated joints, is mediated by in vivo modification of DC. Therefore, we have examined the ability of genetically modified DC to suppress established murine collagen-induced arthritis (CIA) after i.v. delivery. IL-4 has been shown to partially ...
TY - JOUR. T1 - Successful gene therapy via intraarticular injection of adenovirus vector containing CTLA4IgG in a murine model of type II collagen-induced arthritis. AU - Ijima, K.. AU - Murakami, M.. AU - Okamoto, H.. AU - Inobe, M.. AU - Chikuma, S.. AU - Saito, I.. AU - Kanegae, Y.. AU - Kawaguchi, Y.. AU - Kitabatake, A.. AU - Uede, T.. PY - 2001/8/9. Y1 - 2001/8/9. N2 - We previously constructed an adenovirus vector carrying a gene encoding a soluble form of fusion protein, consisting of the extracellular portion of cytotoxic lymphocyte antigen 4 (CTLA4) and the Fc portion of human immunoglobulin G1 (Adex1CACTLA4IgG). Murine type II collagen-induced arthritis (CIA) was treated with Adex1CACTLA4IgG. A single intraarticular injection of 1 × 105 PFU was able to support serum CTLA4IgG at more than 10 μg/ml for at least 12 weeks and was able to inhibit the CIA clinically and histo-logically. In contrast, intravenous, intramuscular, or subcutaneous injection of 1 × 105 PFU was unable to ...
Abstract: To evaluate the effect of methotrexate on collagen-induced arthritis, micro-computed tomography (micro-CT) and histopathological analyses were used in male Wistar rats. Rats were divided randomly into three groups. Group 1 was treated with 0.9% saline, and groups 2 and 3 were boosted with type Ⅱ collagen. From day 21 to 42, groups 1 and 2 were orally treated with 0.9% saline and group 3 was orally treated with 1.5 mg/kg methotrexate. All rats were sacrificed at day 42 after the first collagen treatment. Micro-CT analyses showed bony parameters, such as bone volume and trabecular number, were decreased in group 2 compared to group 1, and these parameters were recovered in group 3. Histopathological examination and pathological parameter scoring showed that the knee joints of rats in group 2 had severe joint destruction, showing cartilage and bone erosion, enlarged cavities with inflammatory cell infiltration and activation of synovial fibroblasts. By contrast, these changes were ...
TY - JOUR. T1 - Anti-inflammatory effects of licorice and roasted licorice extracts on TPA-induced acute inflammation and collagen-induced arthritis in mice. AU - Chung, Won Yoon. AU - Kim, Ki Rim. AU - Jeong, Chan Kwon. AU - Park, Kwang Kyun. AU - Choi, Jong Hoon. AU - Park, Jung Han Yoon. AU - Lim, Soon Sung. PY - 2010/5/6. Y1 - 2010/5/6. N2 - The anti-inflammatory activity of licorice (LE) and roated licorice (rLE) extracts determined in the murine phorbol ester-induced acute inflammation model and collagen-induced arthritis (CIA) model of human rheumatoid arthritis. rLE possessed greater activity than LE in inhibiting phorbol ester-induced ear edema. Oral administration of LE or rLE reduced clinical arthritis score, paw swelling, and histopathological changes in a murine CIA. LE and rLE decreased the levels of proinflammatory cytokines in serum and matrix metalloproteinase-3 expression in the joints. Cell proliferation and cytokine secretion in response to type II collagen or ...
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Genome-wide association studies have identified various susceptibility variants and loci associated with incidence of rheumatoid arthritis (RA) in different populations. One of these is T cell activation Rho GTPase activating protein (TAGAP). The present study sought to measure the expression of TAGAP in RA patients, CD4(+) T cells subsets from healthy humans and in mice with collagen-induced arthritis. Peripheral blood mononuclear cells (PBMC) from RA patients and tissues of arthritic mice at different stages of the disease were used for the evaluation of TAGAP mRNA expression. Increased TAGAP expression was observed in RA patients compared to healthy controls, and there were differences in the expression level of TAGAP in the tissues of mice with experimental arthritis. Gene expression in CD4(+) T cells from healthy humans was greatest 4 h after activation and protein expression was greatest after 24 h. The expression of TAGAP was not correlated with CD4(+) lymphocyte subsets which were enriched for
ASCs also promoted Treg generation in peripheral tissues, including dLNs, peritoneum, synovium, and peripheral blood. MSCs (ASCs) on in vitro formation of bone-resorbing osteoclasts and pathological bone loss in the mouse collagen-induced arthritis (CIA) model of RA. We observed that ASCs significantly inhibited receptor activator of NF-B ligand (RANKL)Cinduced osteoclastogenesis in both AMG 487 a contact-dependent and -independent manner. Additionally, ASCs inhibited RANKL-induced osteoclastogenesis in the presence of proinflammatory cytokines such as TNF-, IL-17, and IL-1. Furthermore, treatment with ASCs at the onset of CIA significantly reduced clinical symptoms and joint pathology. Interestingly, ASCs protected periarticular and systemic bone loss in CIA mice by maintaining trabecular bone structure. We further observed that treatment with ASCs reduced osteoclast precursors in bone marrow, resulting in decreased osteoclastogenesis. Moreover, ASCs suppressed autoimmune T cell responses and ...
OBJECTIVE: Endothelins (ETs) are involved in several inflammatory events. The present study investigated the efficacy of bosentan, a dual ETA/ETB receptor antagonist, in collagen-induced arthritis (CIA) in mice. TREATMENT: CIA was induced in DBA/1J mice. Arthritic mice were treated with bosentan (100 mg/kg) once a day, starting from the day when arthritis was clinically detectable. METHODS: CIA progression was assessed by measurements of visual clinical score, paw swelling and hypernociception. Histological changes, neutrophil infiltration and pro-inflammatory cytokines were evaluated in the joints. Gene expression in the lymph nodes of arthritic mice was evaluated by microarray technology. PreproET-1 mRNA expression in the lymph nodes of mice and in peripheral blood mononuclear cells (PBMCs) was evaluated by real-time PCR. The differences were evaluated by one-way ANOVA or Students t test. RESULTS: Oral treatment with bosentan markedly ameliorated the clinical aspects of CIA (visual clinical score,
TY - JOUR. T1 - Intra-articular injection of hyaluronate and indomethacin in rabbits with antigen-induced arthritis. AU - Lo, Yow Jen. AU - Sheu, Ming Thau. AU - Tsai, Wen Chi. AU - Lin, Yun Ho. AU - Li, Jau Le. AU - Liang, Yu Chih. AU - Chang, Chi Ching. AU - Hsieh, Ming-Shium. AU - Chen, Chien Ho. PY - 2007/10. Y1 - 2007/10. N2 - Combined effects of hyaluronate and indomethacin in the treatment of rabbits with antigen-induced arthritis (AIA) were evaluated by assessing joint swelling, C-reactive protein (CRP) and prostaglandin E2 (PGE 2) levels with periodic intra-articular (ia) injections of hyaluronate alone (HA group) and with either a low or high concentration of indomethacin (LI-HA or HI-HA group). End-point analyses included matrix metalloproteinases-3 (MMP-3) activity and macroscopic and histological joint examinations. Results demonstrated that treatment in LI-HA and HI-HA groups resulted in statistically significant suppression of CRP, PGE2, and MMP-3 in comparison with those of HA ...
Mast cells are abundantly expressed in synovial tissues and have been proposed to exert proinflammatory effects primarily based on antibody transfer-induced disease models (28, 29). The mode of mast cell activation and the mechanism by which activated-mast cells mediate antigen-induced arthritis are largely unknown and likely complex. We now provide direct in vivo evidence that IL-33 plays a major role in mast cell activation in the context of antigen-induced arthritis. Thus, IL-33 enhanced CIA when ST2−/− mice were reconstituted with BMMCs from WT but not from ST2−/− mice (Fig. 5). Our data also provide mechanisms by which mast cells could promote inflammatory synovitis (Fig. 6). IL-33 induces mast cell production of IL-1, IL-6, IL-13, and a range of chemokines (13, 14, 30) (Fig. 4). Because both IL-1 and IL-6 play crucial roles in the induction of Th17 cells (31-33), a key pathogenic cell type in arthritis (21, 22), our studies indicate a relationship between ST2/IL-33 function and ...
IL-17 is implicated in the pathogenesis of rheumatoid arthritis (RA) and has previously been shown to be induced by tumor necrosis factor (TNF) in vitro. The aim of this study was to assess the impact of TNF inhibition on IL-17 production in collagen-induced arthritis, a model of RA. TNF blockade using TNFR-Fc fusion protein or anti-TNF monoclonal antibody reduced arthritis severity but, unexpectedly, expanded populations of Th1 and Th17 cells, which were shown by adoptive transfer to be pathogenic. Th1 and Th17 cell populations were also expanded in collagen-immunized TNFR p55(-/-) but not p75(-/-) mice. The expression of IL-12/IL-23 p40 was up-regulated in lymph nodes (LN) from p55(-/-) mice, and the expansion of Th1/Th17 cells was abrogated by blockade of p40. Treatment of macrophages with rTNF also inhibited p40 production in vitro. These findings indicate that at least one of the ways in which TNF regulates Th1/Th17 responses in arthritis is by down-regulating the expression of p40. Finally,
Nimesulide is a COX-2 inhibitor used for symptomatic relief of rheumatoid arthritis. Leflunomide is an anti-pyrimidine used to manage the progression of rheumatoid arthritis. Herein we studied the influence of nimesulide and leflunomide combination in terms of disease symptoms and progression using collagen-induced arthritis model in mice, as a model for rheumatoid arthritis. Collagen induced arthritis was induced by immunization with type II collagen. Assessment of joint stiffness and articular hyperalgesia were evaluated using a locomotor activity cage and the Hargreaves method, respectively. Disease progression was assessed via arthritic index scoring, X-ray imaging, myeloperoxidase enzyme activity and histopathologic examination. Nimesulide induced only transient symptomatic alleviation on the top of decreased leucocytic infiltration compared to arthritis group. However, nimesulide alone failed to induce any significant improvement in the radiological or pathological disease progression. Leflunomide
Rheumatoid arthritis (RA) is a systemic autoimmune disease mediated by T cells. Collagen type II (CII) is one of the autoantigens associated with RA. CII263-272 is a predominant CII antigenic peptide that can induce T-cell activation upon binding to MHC and interaction with the appropriate T-cell receptor (TCR). Altered CII263-272 peptides with substitution of specific amino acids could bind to RA-associated HLA-DR4/1 with no T cell stimulating effects and could inhibit T cell activation in RA. We performed this study to evaluate the effect of mucosal administration and to explore the mechanism of the inhibitory effect of altered CII263-272 peptide (267Q --> A, 270K --> A and 271G --> A) on collagen induced arthritis (CIA). CIA was induced in Lewis rats by immunization with bovine CII. Altered CII263-272 peptide was given intranasally beginning from arthritis onset. Wild CII263-272 peptide or PBS was administered as controls. Therapeutic effects were evaluated by arthritis scores, body weight ...
TY - JOUR. T1 - Collagen-induced arthritis and TCRs in SWR and B10.Q mice expressing an E(α)/(k) transgene. AU - Griffiths, M. M.. AU - Nabozny, G. H.. AU - Hanson, J.. AU - Harper, D. S.. AU - McCall, S.. AU - Moder, K. G.. AU - Cannon, G. W.. AU - Luthra, H. S.. AU - David, C. S.. PY - 1994. Y1 - 1994. N2 - B10.E(α)/(k) transgenic mice were mated with H2-E- B10.Q and SWR mice. F1 and F1 x parental strain backcross progeny were tested for arthritis and autoimmune reactivity to mouse type II collagen (MII) after immunization with bovine, chick, deer, or human type II collagen. The results were correlated with the H-2 haplotype (b/q vs q/q) and the TCR Vβ profile of peripheral blood T cells in each mouse. Hybrid progeny expressed TCR profiles different from either parent because of the TCR Vβ genomic deletions of SWR mice (Vβa), the wild-type TCR allele of C57Bl/10 (B10) mice (Vβb), and the intrathymic negative selection processes resulting from cell surface expression of ...
Recently, therapy with bone marrow mesenchymal stem cells (BMMSCs) has been attempted to relieve rheumatoid arthritis (RA) and reconstruct cartilage injury. However, treatment has been unsuccessful in complete prevention of persistent cartilage destruction and resulted in inferior outcomes of cartilage regeneration. Scaffolds are an important construct in the field of cartilage tissue engineering, but their role in arthritis treatment has not yet been fully examined. Here, we transplanted two types of scaffold-assisted BMMSCs: fibrin gel- and poly(l-lactide-co-glycolide)−poly(ethylene glycol)−poly(l-lactide-co-glycolide) (PLGA−PEG−PLGA) hydrogel-assisted BMMSCs referred as FGB and HGB groups, respectively, into subchondral defects for the treatment of antigen-induced arthritis. The administration of exogenous BMMSCs ameliorated joint swelling and decreased both joint surface temperature and inflammatory cytokine levels in both groups. Immune cell composition of the inflammation of surrounding
Objectives: To establish if changes in Th1/Th17 cell populations previously reported in experimental arthritis occur in patients with rheumatoid arthritis (RA) treated with anti-tumour necrosis factor α (TNFα) agents, and whether the therapeutic response to anti-TNFα is compromised in patients and mice because of elevated Th17/IL-17 levels. Finally, to assess the efficacy of combined blockade of anti-TNFα and anti-IL-17 in experimental arthritis. Methods: A longitudinal study of two independent cohorts (cohort 1, n=24; cohort 2, n=19) of patients with RA treated with anti-TNFα biological agents was carried out to assess their Th17/IL-17 levels before and after the start of anti-TNFá therapy. IL-12/23p40 production was assessed in plasma Peripheral blood lymphocytes (PBLs) and monocytes. Mice with collagen-induced arthritis (CIA) were treated with anti-TNFα alone, anti-IL17 alone or a combination of the two. Efficacy of treatment and response was assessed from changes in Disease Activity Score 28
In countries where parasitic infections are endemic, autoimmune disease is relatively rare, leading to the hypothesis that parasite-derived immunomodulators may protect against its development. Consistent with this, we have previously demonstrated that ES-62, a 62 kDa phosphorylcholine (PC)-containing glycoprotein that is secreted by filarial nematodes, can exert anti-inflammatory action in the murine collagen-induced arthritis (CIA) model and human rheumatoid arthritis-derived synovial tissue cultures. As a first step to developing ES-62-based drugs, the aim of this study was to determine whether the PC-moiety of ES-62 was responsible for its anti-inflammatory actions. We compared the anti-inflammatory activity of a PC-free form of recombinant ES-62 (rES-62) and a synthetic PC-ovalbumin conjugate (OVA-PC) with that of native ES-62 in the CIA model and synovial tissues from patients with rheumatoid arthritis. Results: The anti-inflammatory actions of ES-62 in CIA appear to be dependent on the PC ...
article{418b5550-2321-4395-ab0c-946f90945ceb, abstract = {OBJECTIVE: To characterize the arthritis-modulating effects of 3 non-major histocompatibility complex (MHC) quantitative trait loci (QTLs) in rat experimental arthritis in the disease-resistant E3 strain, and to investigate the disease-modulating effects of the MHC region (RT1) in various genetic backgrounds. METHODS: A congenic fragment containing Ncf1 along with congenic fragments containing the strongest remaining loci, Pia5/Cia3 and Pia7/Cia13 on chromosome 4, were transferred from the arthritis-susceptible DA strain into the background of the completely resistant E3 strain. The arthritis-regulatory potential of the transferred alleles was evaluated by comparing the susceptibility to experimental arthritis in congenic rats with that in E3 rats. The RT1(u) haplotype from the E3 strain was transferred into the susceptible DA strain (RT1(av1)), and various F(1) and F(2) hybrids were generated to assess the effects of RT1 on arthritis ...
Background A long-term existing schistosome infection can certainly help in keeping immuno-homeostasis, thus providing protection against various types of autoimmune diseases to the infected sponsor. human rheumatoid arthritis. Illness by Schistosoma japonicum significantly reduced the severity and the incidence of experimental autoimmune collagen-induced arthritis. However, this beneficial effect can only be provided by a pre-established acute stage of illness but not by a pre-established early stage of the illness. The safety against collagen-induced arthritis correlated with reduced levels of anti-collagen II IgG, especially the subclass of IgG2a. Moreover, in safeguarded mice increased levels of IL-4 were present at the time of collagen II injection together with sustained higher IL-4 levels during the course of arthritis development. In contrast, in unprotected mice minimal levels of IL-4 were ITF2357 present at the initial stage of collagen II challenge together with lack of IL-4 induction ...
METHODS: Female wistar (Ws) rats were used in this study. CIA was induced by Native bovine type II collagen emulsified with complete Freunds adjuvant (CFA). Beta-END was administered i.p. to CIA rats every other day from the 14th day (secondary immunization) to the 35th day after primary immunization. Clinical assessments were performed by two independent, blinded examiners every other day. Pathological and radiological observations were taken on the 35th day after the primary immunization. Tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), regulated upon activation, normal T-cell expressed and secreted (RANTES), inducible NO syntheses (iNOS), matrix metalloproteinase-2 (MMP-2) and MMP-9 mRNA expression of synovium tissues of CIA rats was estimated by quantitative RT-PCR. The frequency of spleen Th1 and Th2 cells were assessed by fluorescence activated cell sorter (FACS) assay ...
Introduction: The Vbeta12-transgenic mouse was previously generated to investigate the role of antigen-specific T cells in collagen-induced arthritis (CIA), an animal model for rheumatoid arthritis. This mouse expresses a transgenic collagen type II (CII)-specific T-cell receptor (TCR) beta-chain and consequently displays an increased immunity to CII and increased susceptibility to CIA. However, while the transgenic Vbeta12 chain recombines with endogenous alpha-chains, the frequency and distribution of CII-specific T cells in the Vbeta12-transgenic mouse has not been determined. The aim of the present report was to establish a system enabling identification of CII-specific T cells in the Vbeta12-transgenic mouse in order to determine to what extent the transgenic expression of the CII-specific beta-chain would skew the response towards the immunodominant galactosylated T-cell epitope and to use this system to monitor these cells throughout development of CIA. Methods: We have generated and ...
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TY - JOUR. T1 - Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. AU - Joyce-Shaikh, Barbara. AU - Bigler, Michael E.. AU - Chao, Cheng Chi. AU - Murphy, Erin E.. AU - Blumenschein, Wendy M.. AU - Adamopoulos, Iannis. AU - Heyworth, Paul G.. AU - Antonenko, Svetlana. AU - Bowman, Edward P.. AU - McClanahan, Terrill K.. AU - Phillips, Joseph H.. AU - Cua, Daniel J.. PY - 2010/3/15. Y1 - 2010/3/15. N2 - DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities. Because DAP12 has no extracelluar binding domains, it must pair with cell surface receptors for signal transduction. There are at least 15 known DAP12-associating cell surface receptors with distinct temporal and cell type-specific expression patterns. Our aim was to determine which receptors may be important in ...
B cells have a central role in the pathogenesis of collagen-induced arthritis (CIA), an animal model of the autoimmune disease rheumatoid arthritis. In this report, a specific subset of an innate type of B cells, B-1 B cells, have been studied for the involvement in CIA. The B-1 B cells were shown to produce small amounts of collagen-specific antibodies upon stimulation in vitro, suggesting that they play a minor role in the development of CIA. This report also includes how marginal zone B cells, another innate type of B cells with natural collagen-reactivity, can be identified in the medullary sinuses of lymph nodes of collagen-immunized mice, implying involvement in auto antigen trapping. ...
Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM. Y-320 also inhibits the production of IFN-γ and TNF-α by mouse CD4 T cells stimulated with IL-15, CXCL12, and anti-CD3 mAb. Y-320 (0.3-3 mg/kg p.o.) ameliorates collagen-induced arthritis (CIA) in Mice with a reduction of IL-17 mRNA in arthritic joints, and also shows therapeutic effects on CIA in cynomolgus monkeys. Moreover, Y-320 shows a synergistic effect in combination with anti-TNF-α mAb on chronic-progressing CIA in mice. Selleck Chemicals Y-320, IL-17 Inhibitor. 26 Sep 2014. Ushio H, et al. (2013). A new phenylpyrazoleanilide, y-320, inhibits interleukin 17 production and ameliorates collagen-induced arthritis in mice and cynomolgus monkeys. Pharmaceuticals (Basel). 7 (1): 1-17. doi:10.3390/ph7010001. PMC 3915191 . PMID 24366113 ...
Therapeutic Treatment of Arthritic Mice with 15-Deoxy Δ12,14-Prostaglandin J2 15d-PGJ2 Ameliorates Disease through the Suppression of Th17 Cells and the Induction of CD4 CD25−FOXP3 Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Rheumatoid arthritis progression has been markedly improved by the application of biological anti-RA agents, which suppress RA activity and also repair affected joint space under certain conditions.
Elevated expression of LL-37 and its activating protease have been described in RA patients (6, 64), and mechanistic studies are beginning to unravel the role of LL-37 in this disease. Periarticular osteopenia is a common finding among patients with RA (65), and LL-37 induces apoptosis of osteoblasts, which could contribute to reduced bone formation in arthritic joints (7). Furthermore, a recent report characterized elevated expression of LL-37 primarily in the osteoclasts and granulocytes within the human RA synovium (66). Using a pristane-induced arthritis model in rats, upregulation of rCRAMP, the rat ortholog of LL-37, was demonstrated in granulocytes, macrophages, and γδ T cells of synovial fluid. Importantly, transfer of pristane-exposed neutrophils induced arthritis, whereas type I IFN or autoantibody responses in control rats did not (66). This suggests that LL-37 may contribute to arthritis development, but further studies are needed to clarify its role.. An association between ...
Phasic changes in the immune response were observed in rats and mice with adjuvant disease: stimulation of antibody formation on the seventh day after injection of Freunds complete adjuvant (FCA)...
Doctors use the rheumatoid arthritis severity scale to track the level and progress of your disease. Find out what it measures and what your numbers mean.
We have now previously reported a rise in interleukin (IL)-oneβ and IL-17 amounts, along with a ongoing activation of caspase-1 in early rheumatoid arthritis (RA) patients. These success recommend that medications concentrating on IL-1β regulatory pathways, Together with tumor necrosis variable (TNF), may perhaps constitute promising therapeutic agents in early RA. We have just lately utilized a THP-one macrophage-like mobile line to screen 2320 compounds for those who down-regulate both of those IL-1β and TNF secretion. Celastrol was one of the most promising therapeutic candidates determined in that review. Our major aim within the existing get the job done was to research no matter whether administration of celastrol can attenuate inflammation in a very rat design of adjuvant-induced arthritis (AIA). Additionally, since IL-1β is thought to Perform a task within the polarization of Th17 cells, we also investigate irrespective of whether administration of digoxin, a specific inhibitor of ...
The application of tumor necrosis factor inhibitors (TNFi) is a major breakthrough in the treatment of rheumatoid arthritis (RA). While the anti-inflammatory nature of TNFi is thought to contribute to the therapeutic effects, recent data show that the pharmacology of TNF- blockade is probably...
The arthritis-susceptible DA rat is one of the most commonly used rat strains for genetic linkage analysis and is instrumental for the identification of many genetic loci. Even though DA rats were kept as inbred lines at different institutes and suppliers, it became obvious that the various breeding …
Background The systems underlying tolerance maintenance and induction in autoimmune arthritis stay elusive. to na?ve rodents ameliorated the advancement of CII-induced joint disease. Bottom line Our data recommend that endogenous display of the CII-peptide on N cells can be one of the essential members to joint disease patience induction and maintenance. Electronic ancillary materials The online edition of this content (doi:10.1186/s13075-016-1037-7) contains supplementary materials, which is obtainable to authorized users. IgG ELISA Heat-killed L37Ra (Difco,?BD Biosciences,?Franklin Ponds, New Shirt,?USA) 0.4?mg/ml was dissolved in carbonate barrier, and filtered through a 22?m Millipore filtration system. A 96-well dish (Nunc Maxisorp) was covered with 100?d per good of the option and incubated in 4?C further and overnight blocked with PBS with BSA 1?%, Tween 1?%. The serum was serially diluted from 1:8 to 1:512 and the dish was incubated at 4?C overnight. Biotinylated goat anti-mouse IgG ...
Stem cell-derived tissue- associated regulatory T cells ameliorate the development of autoimmune arthritis. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
OBJECTIVE: We studied histological changes in the cell populations of subchondral bone marrow resulting from inflammation in animal models of arthritis. Inflammation in intraosseous spaces and the effect of treatment with the aminobisphosphonate zoledronate were assessed. METHODS: Peripheral blood, femoral bone marrow, and spleen cells were harvested from carrageenan-induced arthritis Sprague-Dawley rats; fluorescence stained for CD3, CD8, CD4, CD11b/c, anti-mononuclear phagocyte (MNP), CD3/CD8, CD3/CD4, and MNP/CD11b/c; and evaluated by flow cytometry. Arthritis was induced in New Zealand white rabbits in 5 treatment groups: normal, arthritis, zoledronate-treated from arthritis induction, or 2 or 4 weeks after induction. Animals were euthanized after 7 weeks and distal femoral condyles were decalcified, processed, sectioned, and stained. Sections were evaluated for several cell types and histological features relevant to inflammation, which were assigned a categorical grade from 0 (healthy ...
Delayed type hypersensitivity. On Day 1 of the study, mice were IV injected with washed sheep red blood cells (SRBC). On Day 6 of the study, mice were treated with either vehicle or Dexamethasone followed by injection of SRBCs into the paws. Injection of SRBCs into the paws of sensitized mice produced an allergic reaction as measured by swelling (paw thickness). Dexamethasone, a steroid anti-inflammatory, significantly reduced footpad swelling as measured using a microcaliper. Data are mean ± SEM; ***p,0.001 compared to vehicle (N=7-8).. The mouse DTH model is a test against an immunological inflammatory response. Animals that received vehicle treatment displayed an increased paw thickness compared to animals administered Dexamethasone, providing an immunological benefit. These data demonstrate a valid methodology for producing an allergic reaction in experimental animals and show that these animals are sensitive to pharmacological agents that are known to reduce allergic reactions.. ...
The other day I was talking with my aunt about her severe arthritis. She kept mentioning that her hands and knees were really bothering her and no matter what she tried, she could get no relief.
University of Melbourne researchers have identified a protein involved in rheumatoid arthritis-induced inflammation that could lead to new drug treatments.
The importance of the BCR and TLR9 in autoimmunity and in the production of autoantibodies is well established but the underlying molecular mechanism still needs to be determined. Here we aim to characterize the BCR-TLR9 crosstalk by its effect on T-bet, as T-bet is activated and regulated by both receptors and has an important role in class-switching to pathological IgG2a in mice. Using primary mouse B cells, we demonstrate that T-bet expression is synergistically elevated by the crosstalk between the BCR and TLR9. To test the effect of this synergy on IgG2a-switching, the levels of switched B cells were checked by functional tests. We found that BCR co-stimulation had no additional effect on TLR9-induced IgG2a expression however the expression of Rad51 was synergistically increased. To check the biological significance of the synergy we compared T-bet expression in B cells from healthy and CIA (collagen-induced arthritis) mice but no differences were found. Taken together, we demonstrate here ...
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WASHINGTON - Some of the worlds largest drugmakers will face an uphill battle next week in their bid to revive a class of experimental arthritis drugs that have been sidelined by safety concerns for nearly two years.. The Food and Drug Administration says there is a clear association between the nerve-blocking medications and incidences of joint failure that led the agency to halt studies of the drugs in 2010. However, the agency also notes that those side effects were less common when the drugs were used at lower doses, potentially leaving the door open for future use. The agency released its safety analysis ahead of a public meeting next week where outside experts will discuss the drugs safety.. On Monday, Pfizer Inc., Johnson & Johnson and Regeneron Pharmaceuticals will make their case to continue studies of the drugs, with safety precautions to protect patients.. The request to restart testing is unusual, since drugmakers often abandon research on experimental drugs that appear to have ...
New data raising safety concerns for Pfizer Incs experimental arthritis drug sent its shares down 3 percent, while lifting shares of rival drugmaker Abbott Laboratories, analysts said.
Arthritis: nonerosive arthritis of two or more peripheral joints, with tenderness, swelling, or effusion; sensitivity = 86%; ... Clinical and Experimental Rheumatology. 28 (6): 892-904.. ... Unlike rheumatoid arthritis, lupus arthritis is less disabling ... "Arthritis Rheum. 46: 175-90. doi:10.1002/1529-0131(200201)46:1,175::AID-ART10015,3.0.CO;2-H. PMC 4020417. PMID 11817589.. ... "Seminars in Arthritis and Rheumatism. 39 (4): 257-68. doi:10.1016/j.semarthrit.2008.10.007. PMC 2813992.. ...
Phase III trials testing the drug in rheumatoid arthritis started in 2007 and are scheduled to run until January 2015. In April ... Herper, Matthew (2 March 2011). "Why Pfizer's Biggest Experimental Drug Got A Name Change". Forbes. Retrieved 3 March 2011. ... It is currently approved for the treatment of rheumatoid arthritis (RA) in the United States and other countries. It has ... Phase II clinical trials tested the drug in rheumatoid arthritis patients that had not responded to DMARD therapy. In a ...
Clinical and Experimental Rheumatology. 27 (2): 347-53. PMID 19473582. Hu PF, Bao JP, Wu LD (2011). "The emerging role of ... Arthritis and Rheumatism. 48 (11): 3118-29. doi:10.1002/art.11303. PMID 14613274. Simopoulou T, Malizos KN, Iliopoulos D, ... Clinical and Experimental Rheumatology. 26 (2): 275-82. PMID 18565249. Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X ... Arthritis and Rheumatism. 60 (11): 3374-77. doi:10.1002/art.24881. PMID 19877065. Clockaerts S, Bastiaansen-Jenniskens YM, ...
However, about one third of UCTD patients will differentiate to a specific autoimmune disease, like rheumatoid arthritis or ... Clinical and Experimental Rheumatology. 22 (3 Suppl 33): S14-S18. PMID 15344591. Bodolay E, Csiki Z, Szekanecz Z, Ben T, Kiss E ... 2008). "Vitamin D deficiency in undifferentiated connective tissue disease". Arthritis Research & Therapy. 10 (5): R123. doi: ... Clinical and Experimental Rheumatology. 21 (3): 313-320. PMID 12846049. Zold E, Szodoray P, Gaal J, Kappelmayer J, Csathy L, et ...
The joints involved tend to be the ankles, knees, and elbows, but arthritis in the hands and feet is possible; the arthritis is ... 2002). "Problems of classification of Henoch Schonlein purpura: an Indian perspective". Clinical and Experimental Dermatology. ... Purpura, arthritis, and abdominal pain are known as the "classic triad" of Henoch-Schönlein purpura. Purpura occur in all cases ... Schönlein associated the purpura and arthritis, and Henoch the purpura and gastrointestinal involvement. The English physician ...
Proposal of an international consensus conference; Arthritis Rheum 2013 Jennette, JC; Overview of the 2012 Revised ... International Chapel Hill Consensus Conference Nomenclature of Vasculitides; Clinical and Experimental Nephrology, 2013. ...
Job-Deslandre C (January 2007). "Idiopathic juvenile-onset systemic arthritis". Orphanet. Orphan number: ORPHA85414. Amaru ... Experimental Hematology. 40 (8): 634-45.e10. doi:10.1016/j.exphem.2012.04.007. PMID 22579713.. ... and has been granted orphan drug designation in the European Union for the treatment of systemic juvenile idiopathic arthritis ... Givinostat for the treatment of systemic-onset juvenile idiopathic arthritis" (PDF). European Medicines Agency. Retrieved 2010- ...
"Clinical and Experimental Immunology. 81 (1): 59-64. doi:10.1111/j.1365-2249.1990.tb05291.x. PMC 1535032. PMID 2199097.. ... "Arthritis Research & Therapy. 4 (2): 134-8. doi:10.1186/ar389. PMC 83843. PMID 11879549.. ... "Arthritis Research & Therapy. 7 (3): R704-13. doi:10.1186/ar1729. PMC 1174964. PMID 15899056.. ... Targoff, IN; Reichlin, M (1985). "Nucleolar localization of the PM-Scl antigen". Arthritis & Rheumatism. 28 (2): 226-30. doi: ...
Specifically, individuals with rheumatoid arthritis and Sjögren syndrome have increased rates of bronchiectasis. In these ... Clinical and Experimental Allergy. 43 (8): 850-873. doi:10.1111/cea.12141. ISSN 1365-2222. PMID 23889240. S2CID 24077597. ... Chatzidionisyou, Aikaterini; Catrina, Anca I. (January 2016). "The lung in rheumatoid arthritis, cause or consequence?". ... The Tohoku Journal of Experimental Medicine. 222 (4): 237-242. doi:10.1620/tjem.222.237. ISSN 1349-3329. PMID 21127394. Kim, C ...
Targoff, IN; Reichlin, M (1985). "Nucleolar localization of the PM-Scl antigen". Arthritis & Rheumatism. 28 (2): 226-30. doi: ... Clinical and Experimental Immunology. 81 (1): 59-64. doi:10.1111/j.1365-2249.1990.tb05291.x. PMC 1535032. PMID 2199097. ... 2002). "Autoantibodies directed to novel components of the PM/Scl complex, the human exosome". Arthritis Research & Therapy. 4 ... arthritis, myositis and scleroderma. Treatment of these patients is symptomatic and is similar to treatment for the individual ...
"Dominant-negative inhibitors of soluble TNF attenuate experimental arthritis without suppressing innate immunity to infection ... It has U.S. F.D.A. approval to treat rheumatoid arthritis, juvenile idiopathic arthritis and psoriatic arthritis, plaque ... juvenile rheumatoid arthritis, psoriasis, psoriatic arthritis, rheumatoid arthritis, and, potentially, in a variety of other ... Moderate to Severe Rheumatoid Arthritis (RA) (Nov 1998)[7]. *Moderate to Severe Polyarticular Juvenile Rheumatoid Arthritis ( ...
The Effect of Salicylates on Experimental Arthritis in Rabbits. Chicago: American Medical Association, 1917. Fantus, Bernard. ... to strengthen New Jersey's competitive position for business and industry The effect of salicylates on experimental arthritis ... Tolu and sugar coating in the disguising of medicines Tungstates of alkaloids-An experimental pharmacologic study X‐Ray ... "Tungstates of alkaloids-An Experimental Pharmacologic Study." The Journal of Laboratory and Clinical Medicine 3, no. 3 (1917): ...
"Novel suppressive function of transitional 2 B cells in experimental arthritis". Journal of Immunology. 178 (12): 7868-78. doi: ... By contrast mouse Bregs in model of collagen-induced arthritis (CIA) were mainly CD21 and CD23 positive. Breg were found in ... Then a role of Bregs was found in many mouse models of autoimmune diseases as rheumatoid arthritis or systemic lupus ... An increase in expression of this molecule has been described in the collagen-induced arthritis model. In order to suppress ...
"The oncoprotein TBX3 is controlling severity in experimental arthritis". Arthritis Research & Therapy. 21 (1): 16. doi:10.1186/ ... KLF12 as a risk locus for rheumatoid arthritis susceptibility". Arthritis and Rheumatism. 58 (8): 2275-86. doi:10.1002/art. ... TBX3 has been implicated in human diseases including the ulnar mammary syndrome, obesity, rheumatoid arthritis and cancer. In ... Genome wide association studies also causally linked TBX3 to rheumatoid arthritis (RA) susceptibility and a recent study ...
There was also no tumor formation seen during the three-month experimental period. Long-term studies need to be carried out to ... Murphy JM, Fink DJ, Hunziker EB, Barry FP (December 2003). "Stem cell therapy in a caprine model of osteoarthritis". Arthritis ... Horses and dogs are most frequently affected by arthritis. Natural cartilage regeneration is very limited. Different types of ... brought back into log phase of cell growth in invitro culture before these are administered for clinical trials or experimental ...
"The Journal of Experimental Medicine. 207 (3): 579-89. doi:10.1084/jem.20090516. PMC 2839155. PMID 20212065.. ... "Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis ...
Advances in Experimental Medicine and Biology. 735. pp. 55-81. doi:10.1007/978-1-4614-4118-2_4. ISBN 978-1-4614-4117-5. PMID ... Arthritis and Rheumatism. 30 (9): 961-6. doi:10.1002/art.1780300901. PMID 2959289. Hourcade D, Miesner DR, Atkinson JP, Holers ... The Journal of Experimental Medicine. 173 (5): 1159-63. doi:10.1084/jem.173.5.1159. PMC 2118866. PMID 1708809. Khera R, Das N ( ... The Journal of Experimental Medicine. 168 (5): 1699-717. doi:10.1084/jem.168.5.1699. PMC 2189104. PMID 2972794. Hing S, Day AJ ...
May 2017). "Response of human rheumatoid arthritis osteoblasts and osteoclasts to adiponectin". Clinical and Experimental ... Adiponectin is a protein hormone that has been shown to be upregulated in rheumatoid arthritis disease pathology, causing the ... bone growth by osteoblasts is a partial cause of the abnormal degradation of bone seen in osteoporosis or rheumatoid arthritis ...
"Serum procalcitonin for discrimination between septic and non-septic arthritis". Clinical and Experimental Rheumatology. 26 (3 ... The study also concluded that PCT outperforms C-reactive protein in differentiating septic arthritis from non-septic arthritis ... PCT at a cutoff value of .5 ng/mL was effective at ruling in septic arthritis in an analysis of over 8000 patients across 10 ... May 2005). "Diagnostic value of serum and synovial procalcitonin in acute arthritis: a prospective study of 42 patients". ...
"Dead Sea bath salts for the treatment of rheumatoid arthritis". Clinical and Experimental Rheumatology. 8 (4): 353-357. PMID ... Researchers have also studied their use in treating arthritis. Bath fizzies are material products designed to effervesce in ...
... a unique inflammatory cytokine with roles in bone biology and arthritis". Arthritis Research & Therapy. 6 (6): 240-7. doi: ... In experimental pneumonia models, IL-17A or IL-17RA knock mice have increased susceptibility to various Gram-negative bacteria ... Lubberts E, Koenders MI, van den Berg WB (2006). "The role of T-cell interleukin-17 in conducting destructive arthritis: ... Th17 cells is also strongly associated rheumatoid arthritis (RA), a chronic disorder with symptoms include chronic joint ...
... and experimental pain in a chronic pain cohort" (PDF). Arthritis and Rheumatism. 52 (5): 1577-84. doi:10.1002/art.21008. hdl: ... Fibromyalgia at Curlie Arthritis - Types - Fibromyalgia by the CDC Questions and Answers About Fibromyalgia by the National ... The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) in 2014 stated that there was a lack of ... 20-30% of people with rheumatoid arthritis and systemic lupus erythematosus may also have fibromyalgia. According to the NHS, ...
Current research applications include transplantation research, induced arthritis and inflammation, experimental allergic ... "The Journal of Experimental Medicine. 124 (2): 227-40. doi:10.1084/jem.124.2.227. PMC 2180468. PMID 4380670.. ... "International Journal of Experimental Pathology. 88 (6): 437-43. doi:10.1111/j.1365-2613.2007.00554.x. PMC 2517339. PMID ... Krinke GJ, Bullock GR, Krinke G (June 15, 2000). "History, Strains and Models". The Laboratory Rat (Handbook of Experimental ...
... rheumatoid arthritis, and psoriatic arthritis. Squamous cell carcinoma has been found on rare occasions in chronic hidradenitis ... Clinical and Experimental Rheumatology. 2 (4): 309-11. PMID 6241861. Velpeau A. Aissele. In: Bechet Jeune Z: Dictionnaire de ... Schneeweiss MC, Kim SC, Schneeweiss S, Rosmarin D, Merola JF (2020). "Risk of inflammatory arthritis after a new diagnosis of ... Vasey FB, Fenske NA, Clement GB, Bridgeford PH, Germain BF, Espinoza LR (1984). "Immunological studies of the arthritis of acne ...
Hilkens CM, Isaacs JD (May 2013). "Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?". Clinical ... The Journal of Experimental Medicine. 195 (1): 15-21. doi:10.1084/jem.20011341. PMC 2196016. PMID 11781361. Monney L, Sabatos ... and Experimental Immunology. 172 (2): 148-57. doi:10.1111/cei.12038. PMC 3628318. PMID 23574312. Mannie MD, Curtis AD (May 2013 ... regulatory T cells play a critical role in granulocyte-macrophage colony-stimulating factor-induced suppression of experimental ...
The effect of D-penicillamine on experimental allergic arthritis in rabbits]". Z Rheumatol. 35 (5-6): 201-9. PMID 60013. ...
... intradermally in diabetes and rheumatoid arthritis patients, subcutaneously in rheumatoid arthritis patients and via ... The Journal of Experimental Medicine. 192 (9): 1213-22. doi:10.1084/jem.192.9.1213. PMC 2193357. PMID 11067871. Lim DS, Kang MS ... Hilkens, C M U; Isaacs, J D (May 2013). "Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?". ... Hilkens, C. M. U.; Isaacs, J. D. (2013-04-10). "Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now ...
Anti-inflammatory Activity of Ocimum americanum L. Essential Oil in Experimental Model of Zymosan-Induced Arthritis. „Am J Chin ... β-Cyclodextrin-complexed (-)-linalool produces antinociceptive effect superior to that of (-)-linalool in experimental pain ...
... -dependent toll-like receptor 9 signaling revealed in experimental arthritis. Science, 319(5863), 624-627. Hussein, ...
An experimental research". Bulletin of the National Board of Health. . *^ Pasteur, Louis (1881). "Sur une maladie nouvelle ... septic arthritis, endocarditis, peritonitis, pericarditis, cellulitis, and brain abscess.[6] ...
Handbook of Experimental Pharmacology. 135 / 2. pp. 363-407. doi:10.1007/978-3-642-60107-1_18. ISBN 978-3-642-64261-6. . ISSN ... "National Institute of Arthritis and Musculoskeletal and Skin Diseases. May 2013. Archived from the original on 2 February 2015. ... Questions and Answers about Acne - US National Institute of Arthritis and Musculoskeletal and Skin Diseases ... Clinical and Experimental Dermatology (Review). 39 (3): 273-7, quiz 277-8. doi:10.1111/ced.12270. PMID 24635060.. ...
"Clinical and Experimental Immunology. 113 (2): 269-75. doi:10.1046/j.1365-2249.1998.00621.x. PMC 1905034 . PMID 9717978.. ... "Substance P in the serum of patients with rheumatoid arthritis". Revue Du Rhumatisme. 64 (1): 18-21. PMID 9051855.. ...
Advances in Experimental Medicine and Biology. 585. pp. 431-41. doi:10.1007/978-0-387-34133-0_28. ISBN 978-0-387-32664-1. . ... Juvenile idiopathic arthritis. *Rheumatoid arthritis *Felty's syndrome. *Palindromic rheumatism. *Adult-onset Still's disease ...
"Clinical and Experimental Immunology. 155 (1): 1-15. doi:10.1111/j.1365-2249.2008.03834.x. PMC 2665673. PMID 19076824.. ... an epidemic of oligoarticular arthritis in children and adults in three connecticut communities". Arthritis and Rheumatism. 20 ... "Experimental and Applied Acarology. 62 (4): 543-555. doi:10.1007/s10493-013-9763-x. PMC 3933768. PMID 24352572.. ... "Experimental & Applied Acarology. 62 (4): 543-55. doi:10.1007/s10493-013-9763-x. PMC 3933768. PMID 24352572.. ...
... "experimental and investigational".[77][78][79][80] Medicine-assisted manipulation, such as manipulation under anesthesia, ... these contraindications include rheumatoid arthritis and conditions known to result in unstable joints.[45] Relative ...
Experimental studies have investigated many different types of stress, and their effects on the HPA axis in many different ... such as rheumatoid arthritis and multiple sclerosis.[7][8][11] ... Though animal models allow for more control of experimental ... circumstances.[15] Stressors can be of many different types-in experimental studies in rats, a distinction is often made ... "The Journal of Experimental Biology. 204 (Pt 22): 3867-76. PMID 11807104.. ...
T-lymphocyte therapies are still in the experimental stage; few are even in clinical trials, none have been FDA approved, and ... pyogenic sterile arthritis, pyoderma gangrenosum, acne) Blau syndrome Chronic recurrent multifocal osteomyelitis and congenital ...
Advances in Experimental Medicine and Biology. 467. pp. 507-16. doi:10.1007/978-1-4615-4709-9_63. ISBN 978-1-4613-7133-5. . ... "Arthritis and Rheumatism. 61 (10): 1305-11. doi:10.1002/art.24460. PMC 2761987. PMID 19790128.. ... "Arthritis and Rheumatism. 63 (11): 3633-9. doi:10.1002/art.30514. PMC 3848710. PMID 21702023.. ... "Arthritis and Rheumatism. 63 (11): 3633-9. doi:10.1002/art.30514. PMC 3848710. PMID 21702023.. ...
... therapy has furthermore proven effective against genital warts in experimental use, but is rarely used for this ... Experimental Dermatology. 11 (3): 241-7. doi:10.1034/j.1600-0625.2002.110307.x. PMID 12102663.. ...
Several experimental and clinical studies have indicated that aberrations and deregulations of the UPS contribute to the ... Sjogren's syndrome and rheumatoid arthritis (RA) predominantly exhibit circulating proteasomes which can be applied as clinical ... Experimental Cell Research. 307 (2): 436-51. doi:10.1016/j.yexcr.2005.03.031. PMID 15950624.. ... activity and have been implicated in autoimmune diseases including systemic lupus erythematosus and rheumatoid arthritis.[16] ...
"The Journal of Experimental Medicine. 213 (1): 1-13. doi:10.1084/jem.20151531. PMC 4710203. PMID 26712804.. ... swelling of affected tissues, such as the upper throat during the common cold or joints affected by rheumatoid arthritis; ...
Hodges RE, Baker EM, Hood J, Sauberlich HE, March SC (May 1969). "Experimental scurvy in man". The American Journal of Clinical ... A 2010 review found no role for vitamin C supplementation in the treatment of rheumatoid arthritis.[52] Vitamin C ... These studies both found that all obvious symptoms of scurvy previously induced by an experimental scorbutic diet with ... "Antioxidants and antiinflammatory dietary supplements for osteoarthritis and rheumatoid arthritis". Alternative Therapies in ...
"Arthritis Rheum. 62 (3): 791-801. doi:10.1002/art.27305. PMC 2838960 . PMID 20187128.. ... Mathematical Modeling and Experimental Observation, Springer, 2015. ... "Arthritis Rheum. 64 (4): 1182-1192. doi:10.1002/art.33444. PMC 3288456 . PMID 22034068.. ... "Arthritis Rheumatol. 67 (6): 1568-1576. doi:10.1002/art.39073. PMC 4446178 . PMID 25708836.. ...
Kelly FJ, Fussell, JC (August 2011)։ «Air pollution and airway disease»։ Clinical and Experimental Allergy 41 (8): 1059-71։ ... Arthritis & Rheumatism 65 (1): 1-11։ PMID 23045170։ doi:10.1002/art.37715։ Արխիվացված օրիգինալից 2016-08-09-ին ... Clinical and Experimental Allergy 41 (4): 482-9։ PMID 21338428։ doi:10.1111/j.1365-2222.2010.03691.x ...
"Arthritis and Rheumatism. 62 (3): 791-801. doi:10.1002/art.27305. PMC 2838960. PMID 20187128.. ... "Journal of Experimental Botany. 69 (6): 1301-1311. doi:10.1093/jxb/erx433. PMID 29309625.. ... "Arthritis and Rheumatism. 64 (4): 1182-92. doi:10.1002/art.33444. PMC 3288456. PMID 22034068.. ... "Experimental Cell Research. 318 (11): 1245-51. doi:10.1016/j.yexcr.2012.03.005. PMID 22465226.. ...
As of September 2012 apremilast is in phase III trials for psoriasis and phase II trials for rheumatoid arthritis. Efficacy in ... with considerable experimental evidence supporting these two hypotheses regarding thalidomide's teratogenicity. Recently, new ... As of March 2014 apremilast has been approved for psoriatic arthritis. In September 2014, the U.S. FDA approved apremilast for ... "FDA approves Otezla to treat psoriatic arthritis". fda.gov. Retrieved 13 June 2014. Muller, George W.; Corral, Laura G.; Shire ...
Another way to tell the age of bones is by bone osteons under a microscope or look for arthritis indicators on the bones. ... Younger adults have fewer and larger osteons while older adults have smaller and more osteon fragments, but arthritis will ...
Chronic arthritis[edit]. In those who have more than two weeks of arthritis, ribavirin may be useful.[4] The effect of ... "The Journal of Experimental Medicine. 207 (2): 429-42. doi:10.1084/jem.20090851. PMC 2822618. PMID 20123960.. ... "Arthritis Research & Therapy. 15 (1): R9. doi:10.1186/ar4137. PMC 3672753. PMID 23302155.. ... Joints are more likely to be affected if they have previously been damaged by disorders such as arthritis.[11] Pain most ...
Discovery of anti-TNF therapy as an effective treatment for rheumatoid arthritis and other autoimmune diseases.[47] ... specialized adult cells to form early stem cells-creating the potential to become any type of mature cell for experimental or ...
... juvenile idiopathic arthritis, psoriatic arthritis, juvenile dermatomyositis, idiopathic thrombocytopaenic purpura, infection ... "Clinical and Experimental Immunology. 25 (3): 480-6. PMC 1541410. PMID 786521.. ... "Arthritis & Rheumatism. 42 (5): 899-909. doi:10.1002/1529-0131(199905)42:5,899::AID-ANR8,3.0.CO;2-L. PMID 10323445.. ... "Arthritis & Rheumatism. 43 (11): 2383-2390. doi:10.1002/1529-0131(200011)43:11,2383::AID-ANR2,3.0.CO;2-D. PMID 11083258.. ...
Several different animal species are susceptible to infection by S.dysgalactiae, but bovine mastitis and infectious arthritis ... The Journal of Experimental Medicine. 57 (4): 571-595. doi:10.1084/jem.57.4.571. ISSN 0022-1007. PMC 2132252 . PMID 19870148. ... The Journal of Experimental Medicine. 61 (3): 335-349. doi:10.1084/jem.61.3.335. ISSN 0022-1007. PMC 2133228 . PMID 19870362. ... "Sources of Streptococcus dysgalactiae in English and Welsh sheep flocks affected by infectious arthritis (joint ill)". The ...
"Clinical & Experimental Immunology. 151 (1): 139-45. doi:10.1111/j.1365-2249.2007.03532.x. PMC 2276935 . PMID 17991288.. ... a cellular link between autoantibodies and inflammatory arthritis". Science. 297 (5587): 1689-92. doi:10.1126/science.1073176. ... "Clinical & Experimental Allergy. 38 (8): 1254-63. doi:10.1111/j.1365-2222.2008.03037.x. PMC 2735457 . PMID 18727793.. ...
Advances in Experimental Medicine and Biology. 507: 117-21. doi:10.1007/978-1-4615-0193-0_19. ISBN 978-0-306-47283-1. . PMID ... Zileuton has shown some beneficial effects in clinical trials for the treatment of rheumatoid arthritis, inflammatory bowel ... Alox5 Gene knockout mice are more susceptible to the development and pathological complications of experimental infection with ... Advances in Experimental Medicine and Biology. 416: 327-31. doi:10.1007/978-1-4899-0179-8_52. PMID 9131168.. ...
Rheumatoid arthritis, including juvenile idiopathic arthritis; osteoarthritis; acute pain.. As per diclofenac. ... Dextromethorphan shows efficacy in experimental pain (nociception) and opioid tolerance. NEUROLOGY, 2005.. ... Rheumatoid arthritis; osteoarthritis; ankylosing spondylitis; juvenile idiopathic arthritis; inflammatory pain; heavy menstrual ... Rheumatoid arthritis.. As per diclofenac. Ethenzamide. Comes in free form; salicylate.. As per diclofenac.. PO.. Not available. ...
... systemic sclerosis juvenile idiopathic arthritis, and psoriatic arthritis.[12][clarification needed] ... Helminthic therapy is an experimental approach that involves inoculation of the patient with specific parasitic intestinal ... Thus, in rheumatoid arthritis there are autoantibodies to IgG Fc but apparently no corresponding T cell response. In systemic ... Systemic autoimmune diseases include SLE, Sjögren's syndrome, sarcoidosis, scleroderma, rheumatoid arthritis, cryoglobulinemic ...
... including arthritis, psoriasis, gastroesophageal reflux disease, irritable bowel syndrome, and migraine.[1] ... "Endolymphatic hydrops: pathophysiology and experimental models". Otolaryngologic Clinics of North America. 43 (5): 971-83. doi ...
"The Journal of Experimental Medicine. 37 (4): 525-42. PMC 2128372 . PMID 19868743. doi:10.1084/jem.37.4.525.. ... Methotrexate is used in the treatment of rheumatoid arthritis (RA),[130] psoriasis,[131] ankylosing spondylitis[132] and ... "The Tohoku Journal of Experimental Medicine. 219 (3): 177-86. PMC 2927105 . PMID 19851045. doi:10.1620/tjem.219.177.. ... Main article: Experimental cancer treatments. Targeted therapies[edit]. Specially targeted delivery vehicles aim to increase ...
An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem ... experimental-arthritis-drug-prevents-stem-cell-transplant-complication/. More in Medicine & Health. * A Trojan Horse delivery ... Experimental arthritis drug prevents stem cell transplant complication Drug fights graft-versus-host-disease in mice ... Experimental arthritis drug prevents stem cell transplant complication. Washington University in St. Louis ...
... because they effectively prevent bone loss and inflammation in most patients with rheumatoid arthritis. They have also been ... a powerful new way to limit bone destruction and inflammation-induced bone loss seen in osteoporosis and rheumatoid arthritis ...
... such as rheumatoid arthritis (RA). However, the regulation of zinc mobilization in immune cells and its role in the ... of zinc by T cells may fuel the poorly controlled immune response that wreaks havoc on joint tissues in rheumatoid arthritis ( ... CD4+ T cells that infiltrated the inflamed joint and that ZIP8 deficiency in CD4+ T cells abrogated collagen-induced arthritis ... Identification of rheumatoid arthritis and osteoarthritis patients by transcriptome-based rule set generation. Arthritis Res. ...
... according to a study published today in the journal Arthritis and Rheumatism. ... Early-stage research has found that a new gene therapy can nearly eliminate arthritis pain, and significantly reduce long-term ... Experimental gene therapy abolishes arthritis pain and lessens joint damage Work proceeding rapidly toward application for ... Experimental gene therapy abolishes arthritis pain and lessens joint damage. University of Rochester Medical Center ...
The aim of this study was to evaluate the therapeutic potential of CARN in rat adjuvant arthritis, in the model of carrageenan ... Effect of Carnosine in Experimental Arthritis and on Primary Culture Chondrocytes. S. Ponist. ,1 F. Drafi. ,1 V. Kuncirova. ,1 ... Effect of Carnosine in Experimental Arthritis and on Primary Culture Chondrocytes,. Oxidative Medicine and Cellular Longevity, ... The experimental protocol was approved by the Ethics Committee of the Institute of Experimental Pharmacology and Toxicology and ...
... Bruna Formentão Araujo,1 Lígia Inez Silva,1 ... M. E. Shirtliff and J. T. Mader, "Acute septic arthritis," Clinical Microbiology Reviews, vol. 15, no. 4, pp. 527-544, 2002. ... Implications for joint destruction and repair," Arthritis and Rheumatism, vol. 33, no. 8, pp. 1170-1179, 1990. View at Google ... Kaya, M. Kaya, N. Gürsan, E. Kireççi, M. Güngörmüş, and H. Balta, "The use of 808 nm light therapy to treat experimental ...
... to develop and test drugs to treat patients with Rheumatoid and Psoriatic arthritis. ... The Cardiff Regional Experimental Arthritis Treatment and Evaluation Centre works alongside volunteer patients from Cardiff and ... Protocol for a randomised controlled trial for Reducing Arthritis Fatigue by clinical Teams (RAFT) using cognitive-behavioural ... Functional analysis of a complement polymorphism (rs17611) associated with rheumatoid arthritis. The Journal of Immunology 194 ...
Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis. ... Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis. ... The NF-κB signaling pathway is implicated in various inflammatory diseases, including rheumatoid arthritis (RA); therefore, ... The p5RHH-p65 siRNA nanocomplexes potently suppressed early inflammatory arthritis without affecting p65 expression in off- ...
The aim of this study was to evaluate the effect FRA and MTX administered alone or in combination in adjuvant arthritis. The ... is still the gold standard for treatment of rheumatoid arthritis (RA). The therapeutic efficacy of low-dose of MTX can be ... rheumatoid arthritis ferulaldehyde; methotrexate; adjuvant arthritis; combination treatment; rheumatoid arthritis ... Ferulaldehyde Improves the Effect of Methotrexate in Experimental Arthritis. Lukáš Slovák 1,* , Karol Švík 1. ...
It recapitulates many of the disease parameters seen in human patients with Lyme arthritis, and thus serves as a model system ... of our understanding of the roles of eicosanoids as inflammatory mediators in the regulation of experimental Lyme arthritis. ... an overall understanding of the host response leading to arthritis resistance or susceptibility remains elusive. In this review ... are powerful regulators of inflammatory responses and thus may be important mediators of Lyme arthritis. ...
Experimental" by people in Harvard Catalyst Profiles by year, and whether "Arthritis, Experimental" was a major or minor topic ... ARTHRITIS that is induced in experimental animals. Immunological methods and infectious agents can be used to develop ... "Arthritis, Experimental" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... 15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive ...
Immunological methods and infectious agents can be used to develop experimental arthritis models. These methods include ... Experimental Arthritis: ARTHRITIS that is induced in experimental animals. ... Experimental Arthritis. Subscribe to New Research on Experimental Arthritis ARTHRITIS that is induced in experimental animals. ... Arthritis, Experimental; Arthritis, Adjuvant; Collagen Arthritis; Arthritides, Collagen; Arthritis, Collagen; Collagen ...
Autoimmunity to type II collagen an experimental model of arthritis.. D E Trentham, A S Townes, A H Kang ... The disease is a chronic proliferative synovitis, resembling adjuvant arthritis in rats and rheumatoid arthritis in humans. ... Journal of Experimental Medicine Sep 1977, 146 (3) 857-868; DOI: 10.1084/jem.146.3.857 ... Native type II co-lagen modified by limited pepsin digestion still produces arthritis, suggesting that type-specific ...
Arthritis research & therapy 2015-4-19 Estrogen regulates T helper 17 phenotype and localization in experimental autoimmune ... This is the first study in which the effects of E2 on Th17 cells have been characterized in experimental autoimmune arthritis. ... The aim of this study was to investigate the effects of estrogen on Th17 cells in experimental arthritis. Ovariectomized DBA/1 ... Treatment with estradiol potently inhibits experimental autoimmune arthritis. Interleukin-17-producing T helper cells (Th17) ...
Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological ... Structure and pathogenicity of antibodies specific for citrullinated collagen type II in experimental arthritis J Exp Med. 2009 ... These antibodies bind cartilage and synovial tissue, and mediate arthritis in mice. Detection of citrullinated CII from RA ... Antibodies to citrulline-modified proteins have a high diagnostic value in rheumatoid arthritis (RA). However, their biological ...
Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis.. Y X Zhao and A ... Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis. ... Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis. ... Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis. ...
Results Deficiency in IL-1Ra predisposes to spontaneous arthritis, which is exacerbated by previous systemic LPS exposure. The ... Objective To seek possible links between arthritis and uveitis pathogenesis related to IL-1 signalling. ... and by intravital videomicroscopy to determine if uveitis developed along with the expected spontaneous arthritis in ankles and ... eye, however, does not develop inflammatory disease despite the progressive arthritis or LPS exposure. Organ-specific ...
Genetics Home Reference related topics: rheumatoid arthritis MedlinePlus related topics: Arthritis Rheumatoid Arthritis ... Study Comparing Doses Of An Experimental Glucocorticoid Compound To Prednisone And Placebo In Rheumatoid Arthritis. This study ... treatment of rheumatoid arthritis. treatment of RA. patients on methotrexate for rheumatoid arthritis. prednisone for ... Arthritis. Arthritis, Rheumatoid. Joint Diseases. Musculoskeletal Diseases. Rheumatic Diseases. Connective Tissue Diseases. ...
The drug was administered orally at a dose of 3, 10 and 30 mg/kg, starting shortly before experimental infection of the mice. A ... Inhibition of clinical arthritis coincided with reduction of inflammatory cell infiltration in the joints, liver and muscle. ... The effects of Prednisolone on the development of Borrelia (B.) burgdorferi-induced clinical arthritis and organ inflammation ... Prednisolone was ineffective when application was initiated after arthritis was fully developed, i.e., 22 days after infection ...
... and persistent triggering infection elsewhere in the body are thought to be important in the pathogenesis of reactive arthritis ... Clinical and experimental evidence for persistent Yersinia infection in reactive arthritis Arthritis Rheum. 1999 Oct;42(10): ... and persistent triggering infection elsewhere in the body are thought to be important in the pathogenesis of reactive arthritis ...
DN-TNF and decoy receptor reduce arthritis in the mouse collagen-induced arthritis model. Arthritis was induced using a 5 mg/kg ... Experimental arthritis was induced on day 0 by i.v. injection of four anti-collagen mAbs (MD Biosciences) at 25 mg/kg each ... Experimental arthritis was induced as in A and hind paw thickness (mean ± SEM) was monitored for 28 days. XENP1595 and ... CIA is another established experimental arthritis model and has been used to demonstrate anti-inflammatory activity of Ab and ...
Brief report: Autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and ... ABMT resulted in amelioration and stabilization of arthritis scores. BM grafts containing T cells and T cell-depleted grafts ... induces long-term drug-free disease remission in patients with juvenile idiopathic arthritis. This study was undertaken to ... further unravel the immunologic mechanisms underlying ASCT by using a mouse model of proteoglycan-induced arthritis (PGIA). For ...
The aim of this research is to address the possible treatment of rheumatoid arthritis disease by comparing and contrasting the ... We hypothesize that these treatments will improve the treatment of rheumatoid arthritis disease. Furthermore, we hope that this ... Among these diseases, approximately 1-2% of the worlds population has rheumatoid arthritis disease, which is a chronic disease ... This conveys that we induced experimental model of RA successfully.. The collagen induced experimental arthritis study (2013) ...
Arthritis induction and treatment. Animal experimental protocols were reviewed and approved by the ethics committee of the ... CST decreases the severity of collagen‐induced arthritis. CIA is a murine experimental disease model that shares a number of ... 9. Delgado M, Abad C, Martinez C, Receta J, Gomariz R P. Vasoactive intestinal peptide prevents experimental arthritis by ... Therapeutic effect of cortistatin on experimental arthritis by downregulating inflammatory and Th1 responses. Elena Gonzalez‐ ...
Inhibition of Collagen-Induced Arthritis by a c-Jun N-Terminal Kinase Inhibitor. Journal of Pharmacology and Experimental ... Inhibition of Collagen-Induced Arthritis by a c-Jun N-Terminal Kinase Inhibitor. Journal of Pharmacology and Experimental ... Inhibition of Collagen-Induced Arthritis by a c-Jun N-Terminal Kinase Inhibitor. Journal of Pharmacology and Experimental ... Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics. ...
Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics. ... rheumatoid arthritis. AIA. adjuvant-induced arthritis. BCR. B cell antigen receptor. Btk. Brutons tyrosine kinase. CAIA. ... collagen antibody-induced arthritis. CIA. collagen-induced arthritis. CRP. C reactive protein. CSF1R. colony-stimulating factor ... Btk Inhibitors for Rheumatoid Arthritis. Daigen Xu, Yong Kim, Jennifer Postelnek, Minh Diem Vu, Dong-Qing Hu, Cheng Liao, Mike ...
Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen- ... Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen- ... Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen- ... Suppression of ongoing experimental arthritis by a Chinese herbal formula (Huo-luo-xiao-ling dan) involves changes in antigen- ...
Activation of macrophages in an experimental rat model of arthritis induced by Erysipelothrix rhusiopathiae infection. Infect ... Activation of macrophages in an experimental rat model of arthritis induced by Erysipelothrix rhusiopathiae infection. ... Activation of macrophages in an experimental rat model of arthritis induced by Erysipelothrix rhusiopathiae infection. ...
A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid arthritis patients. Yuki ... "Experimental immunology. A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid ... "Experimental immunology. A novel peptide from TCTA protein inhibits proliferation of fibroblast-like synoviocytes of rheumatoid ... Nanke Y, Yago T, Kobashigawa T, Kawamoto M, Yamanaka H, Kotake S. Experimental immunology. A novel peptide from TCTA protein ...
  • We work alongside volunteer patients from Cardiff and the Vale University Health Board , to develop and test drugs to treat patients with Rheumatoid and Psoriatic arthritis. (cardiff.ac.uk)
  • Rheumatoid and Psoriatic Arthritis are chronic inflammatory joint conditions that result in pain, disability, joint damage and reduced quality of life. (cardiff.ac.uk)
  • To improve the outcome of patients with rheumatoid and psoriatic arthritis by developing new treatments and diagnostic tests that will lead to more patients achieving disease remission. (cardiff.ac.uk)
  • Testing these novel treatments in patients with Rheumatoid and Psoriatic Arthritis will be facilitated by the South East Wales Trials Unit and the Clinical Research Facility at University Hospital of Wales. (cardiff.ac.uk)
  • when member meets criteria in CPB 0658 - Psoriasis and Psoriatic Arthritis: Targeted Immune Modulators . (aetna.com)
  • psoriatic arthritis that associated with severe psoriasis , classically affecting the terminal interphalangeal joints. (thefreedictionary.com)
  • Efficacy Safety and Tolerability Study of Apremilast to Treat Early Oligoarticular Psoriatic Arthritis. (centerwatch.com)
  • This clinical study will test the effects of a drug called apremilast in oligoarticular psoriatic arthritis with less than 2 years of disease duration. (centerwatch.com)
  • In previous studies, apremilast has been shown to be safe and efficacious in reducing signs and symptoms of psoriatic arthritis, as well as improving physical function. (centerwatch.com)
  • This study will compare the effects of apremilast to placebo on psoriatic arthritis subjects in which the number of affected joints is limited (greater than 1 but less or equal to 4). (centerwatch.com)
  • We translate our questions and findings by studying rheumatoid arthritis (RA) and psoriatic arthritis (PsA) as key examples of chronic inflammatory diseases and as model systems to investigate the immune system at the site of inflammation in humans. (kcl.ac.uk)
  • Using multiparameter flow cytometry, RNA sequencing, Luminex, cellular and functional assays, we have studied the presence, function and regulation of IL-17A producing CD4+ (Th17) and CD8+ (Tc17) T cells in the context of rheumatoid and psoriatic arthritis. (kcl.ac.uk)
  • We've got the doctor-approved details on causes, symptoms, treatments, and a jillion other facts and tips that can make life with psoriatic arthritis easier. (healthcentral.com)
  • Whether you've just been diagnosed or worry you could have psoriatic arthritis, you're probably nervous, confused, and maybe even a little scared. (healthcentral.com)
  • On this page alone, you'll discover the realities and challenges of the condition, but also the best treatments, helpful lifestyle changes, where to find your psoriatic arthritis (PsA) community, and all the crucial information to help you not just manage-but thrive. (healthcentral.com)
  • Most people with psoriatic arthritis will also have psoriasis-that's not typical with rheumatoid arthritis. (healthcentral.com)
  • Psoriatic arthritis usually shows up in only one joint, like one knee, whereas RA typically affects both. (healthcentral.com)
  • Glucosamine and chondroitin are often touted as helping with arthritis, but all the studies have been done in osteoarthritis, not psoriatic arthritis. (healthcentral.com)
  • What Is Psoriatic Arthritis, Anyway? (healthcentral.com)
  • Given that its name references psoriasis, it's easy to think that psoriatic arthritis (PsA) is a complication or even form of the condition that causes red, scaly plaques on the skin. (healthcentral.com)
  • Right now, 8 million people in the US are living with psoriasis, and 10-30% of them have psoriatic arthritis. (healthcentral.com)
  • What Causes Psoriatic Arthritis in the First Place? (healthcentral.com)
  • Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others. (wikipedia.org)
  • The p5RHH-p65 siRNA nanocomplexes potently suppressed early inflammatory arthritis without affecting p65 expression in off-target organs or eliciting a humoral response after serial injections. (jci.org)
  • Lyme arthritis is an inflammatory arthritis caused by infection of mice with the spirochete, Borrelia burgdorferi. (prohealth.com)
  • Chan TY, Yen CL, Huang YF, Lo PC, Nigrovic PA, Cheng CY, Wang WZ, Wu SY, Shieh CC. Increased ILC3s associated with higher levels of IL-1ß aggravates inflammatory arthritis in mice lacking phagocytic NADPH oxidase. (harvard.edu)
  • We have found that intradermal injection of native type II collagen extracted from human, chick or rat cartilage induces an inflammatory arthritis in approximately 40% of rats of several strains whether complete Freund's adjuvant or incomplete Freund's adjuvant is used. (rupress.org)
  • Articular damage is associated with intraosseous inflammation in the subchondral bone marrow of joints affected by experimental inflammatory arthritis and is modified by zoledronate treatment. (jrheum.org)
  • CONCLUSION: Intraosseous bone marrow inflammation was observed in carrageenan-induced inflammatory arthritis in rats and rabbits. (jrheum.org)
  • Pharmacological inhibition of γ-secretase and antisensemediated knockdown of Notch attenuates the severity of inflammatory arthritis, including arthritis indices, paw thickness, tissue damage and neutrophil infiltration, and reduces the levels of active NF-KB, ICAM-1, proinflammatory cytokines and matrix metalloproteinase-3 activity in the mouse model of RA. (elsevier.com)
  • IL-17A-producing T cells are therefore thought to play a pivotal role in the immunopathology of inflammatory arthritis. (kcl.ac.uk)
  • This project has created an extensively phenotyped cohort of early inflammatory arthritis patients (362 to date) with linked, detailed pathobiological data. (qmul.ac.uk)
  • Reactive arthritis, formerly known as Reiter's syndrome, is a form of inflammatory arthritis that develops in response to an infection in another part of the body (cross-reactivity). (wikipedia.org)
  • The manifestations of reactive arthritis include the following triad of symptoms: an inflammatory arthritis of large joints, inflammation of the eyes in the form of conjunctivitis or uveitis, and urethritis in men or cervicitis in women. (wikipedia.org)
  • An asymmetrical inflammatory arthritis of interphalangeal joints may be present but with relative sparing of small joints such as the wrist and hand. (wikipedia.org)
  • Methotrexate (MTX) is still the gold standard for treatment of rheumatoid arthritis (RA). (mdpi.com)
  • The purpose of this study is to compare the safety and efficacy of multiple doses of PF-04171327, an experimental glucocorticoid drug, to prednisone at 5 mg or 10 mg and placebo in the treatment of rheumatoid arthritis. (clinicaltrials.gov)
  • The aim of this research is to address the possible treatment of rheumatoid arthritis disease by comparing and contrasting the effectiveness and influence that treatments have on treating the disease. (scirp.org)
  • We hypothesize that these treatments will improve the treatment of rheumatoid arthritis disease. (scirp.org)
  • This work provides a powerful rationale for the assessment of the efficacy of cortistatin as a novel therapeutic approach to the treatment of rheumatoid arthritis. (pubmedcentralcanada.ca)
  • Our results provide evidence of the contribution of PARP-1 to the progression of arthritis and identify this protein as a potential therapeutic target for the treatment of rheumatoid arthritis. (ugr.es)
  • The study is to explore the safety and efficacy of BM-SC transplantation in treatment of rheumatoid arthritis. (clinicaltrials.gov)
  • Lymph node Th17 cells were also examined in ovariectomized estrogen receptor α-knockout mice (ERα-/-) and wild-type littermates, treated with E2 or placebo and subjected to antigen-induced arthritis. (sigmaaldrich.com)
  • Similarly, gene deletion of FcγR prevents some aspects of chronic inflammation in antigen-induced arthritis (AIA). (biomedcentral.com)
  • Purpose: The purpose of this study was to assess the feasibility of inflammation detection in an antigen-induced arthritis model using fluorescent leukocytes and optical imaging. (elsevier.com)
  • Conclusion: Inflammation in antigen-induced arthritis can be detected with ex vivo labeled allogenic leukocytes and optical imaging. (elsevier.com)
  • TGP was orally administered for 3 months to New Zealand rabbits with antigen-induced arthritis (AIA). (biomedcentral.com)
  • With the Dumonde-Glynn model of antigen-induced arthritis, a rabbit model was developed to examine the histopathologic differences between normal and arthritic joints in the same animal infected by intraarticular injections of Staphylococcus aureus. (umn.edu)
  • The disease is a chronic proliferative synovitis, resembling adjuvant arthritis in rats and rheumatoid arthritis in humans. (rupress.org)
  • HLXL (2.3 g/Kg) was fed to Lewis (RT.1[super]1) rats daily by gavage beginning at the onset of arthritis and then continued through the observation period. (harvard.edu)
  • Highly arthritis-susceptible DA rats express IL-1beta in the articular cartilage. (ki.se)
  • Thus, the current work aimed to evaluate the effects of CM in Adjuvant-induced arthritis and air pouch edema models in rats, which mimic human RA. (karger.com)
  • TFB attenuated the severity of arthritis on paw edema, hind paw volume, and polyarthritis index of AA rats, improved the histological status in AA rats as well. (biomedcentral.com)
  • Rats injected in the hind paw with a mixture of Mycobacterium butirricum emulsified in mineral oil (FA) developed a severe polyarthritis that shared some immunological features with human rheumatoid arthritis. (unipg.it)
  • However, experimental deficiency of Th1-promoting cytokines, such as IL-12 and interferon (IFN)-γ, has been shown to increase Th17 cell differentiation and paradoxically exacerbate RA in animal models 12 . (nature.com)
  • CIA in the arthritis-prone DA rat was used to study potent joint destructive cytokines (RANKL and IL-1â) in evolving arthritis, as assessed by immunohistochemistry. (ki.se)
  • Although arthritis may be initiated by impact loading and other mechanical agents acting on the joint, pro-inflammatory eicosanoids and cytokines play an important role in the progression of the disease [ 4 , 5 ]. (springer.com)
  • Cytokines play an essential pathogenic role in rheumatoid arthritis (RA). (wiley.com)
  • Treated groups did not show any reduction in inflammatory cytokines in the knee joints of animals affected by the disease compared to the control, although there were higher concentrations of TGF-β1 in all experimental groups. (biomedcentral.com)
  • Furthermore, the complexity of cytokines in the pathogenesis of arthritis came to focus when IL-10 deficient mice were studied. (lu.se)
  • Effector CD4+ T cells are important contributors to the chronic joint inflammation in rheumatoid arthritis (RA), through their production of pro-inflammatory cytokines. (kcl.ac.uk)
  • Type I or III collagen extracted from skin, cartilage proteoglycans and alpha1(II) chains were incapable of eliciting arthritis, as was type II collagen injected without adjuvant. (rupress.org)
  • These antibodies bind cartilage and synovial tissue, and mediate arthritis in mice. (nih.gov)
  • Rheumatoid arthritis is a chronic autoimmune disease of unknown aetiology characterised by chronic inflammation in the joints and subsequent destruction of the cartilage and bone. (pubmedcentralcanada.ca)
  • Cortistatin treatment significantly reduced the severity of established collagen‐induced arthritis, completely abrogating joint swelling and destruction of cartilage and bone. (pubmedcentralcanada.ca)
  • Rheumatoid arthritis (RA) is an autoimmune disease that leads to chronic inflammation in the joints and subsequent destruction of the cartilage and erosion of the bone. (pubmedcentralcanada.ca)
  • Rheumatoid arthritis is a long-term (chronic) disease where the body's immune system attacks the cells that line the joints by mistake, making them swollen, stiff and painful, and over time damaging the joint, cartilage and nearby bone. (isrctn.com)
  • PARP-1 inhibition with 5-aminoisoquinolinone (AIQ) significantly reduces incidence and severity of established collagen-induced arthritis, completely abrogating joint swelling and destruction of cartilage and bone. (ugr.es)
  • The DA rat expressed IL-1beta in articular cartilage, while the arthritis-resistant rat strains did not. (ki.se)
  • This might explain why erosive arthritides are so easily induced in the DA rat and supports the hypothesis that articular chondrocytes may themselves play a major role in cartilage destruction. (ki.se)
  • Rheumatoid arthritis (RA) is a chronic autoimmune disease associated with robust synovial inflammation that culminates in destructive events in cartilage and bone along with bone outgrowths that restrict the mobility of joints [ 1 ]. (karger.com)
  • Rheumatoid arthritis (RA) and osteoarthritis (OA), two common types of arthritis, affect the joints mainly by targeting the synovium and cartilage. (bvsalud.org)
  • Increasing evidence indicates that a significant network connects synovitis and cartilage destruction during the progression of arthritis. (bvsalud.org)
  • This study broadens our understanding of the possible regulatory mechanisms underlying the crosstalk between the synovium and cartilage in the presence of HIF-2alpha, and may suggest potential new anti-arthritis therapies. (bvsalud.org)
  • These results suggest that the TLR-4 and TLR-2 play an important role in the arthritis 39 mechanism and the interaction/block of HA at high molecular mass may reduce inflammation and cartilage 40 injury. (unime.it)
  • Rheumatoid arthritis ultimately results in the destruction of cartilage, bone and ligaments and joint deformity. (clinicaltrials.gov)
  • In patients with rheumatoid arthritis (RA), an inflammatory disease affecting joints, cartilage and bone, neutrophils have delayed apoptosis in synovial fluid and blood because of elevated levels of interleukin (IL)-1, tumor necrosis factor  (TNF-), IL-8, granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) associated with the disease pathology [4, 5]. (termedia.pl)
  • Exacerbation of arthritis was characterized by increased arthritic bone erosion, whereas cartilage damage remained unaffected. (unesp.br)
  • Genetic mutation and pharmacological inhibition of Bruton's tyrosine kinase (Btk) both have been shown to prevent the development of collagen-induced arthritis (CIA) in mice, providing a rationale for the development of Btk inhibitors for treating rheumatoid arthritis (RA). (aspetjournals.org)
  • The project comprises two work-streams: Workstream 1 is managed by Prof Costantino Pitzalis the Centre for Experimental Medicine and Rheumatology, and Workstream 2 is managed at The University of Manchester. (qmul.ac.uk)
  • 15d-PGJ2-loaded nanocapsules ameliorate experimental gout arthritis by reducing pain and inflammation in a PPAR-gamma-sensitive manner in mice. (harvard.edu)
  • The most common types are osteoarthritis and rheumatoid arthritis . (thefreedictionary.com)
  • The objective of the study is to evaluate the analgesic and anti-inflammatory effect of the crude extract of S. dulcis , in an experimental model of osteoarthritis. (mdpi.com)
  • Thank you for sharing this Journal of Pharmacology and Experimental Therapeutics article. (aspetjournals.org)
  • Message Body (Your Name) thought you would be interested in this article in Journal of Pharmacology and Experimental Therapeutics. (aspetjournals.org)
  • abstract = "Objective: To test the hypothesis that Notch signalling plays a role in the pathogenesis of rheumatoid arthritis (RA) and to determine whether pharmacological inhibition of Notch signalling with γ-secretase inhibitors can ameliorate the RA disease process in an animal model.Methods Collagen-induced arthritis was induced in C57BL/6 or Notch antisense transgenic mice by immunisation with chicken type II collagen (CII). (elsevier.com)
  • Napier R, Lee E, Vance E, Lashley S, Uebelhoer L, Lancioni C, Vehe R, Binstadt B, Caspi R, Rosenzweig H. A T Cell Intrinsic Role for Nod2 in Suppression of Th17-Mediated Experimental Arthritis and Uveitis: Implications for Blau Syndrome [abstract]. (acrabstracts.org)
  • Therefore, CD44 targeting with specific monoclonal antibodies (mAbs) should be useful for the inhibition of collagen-induced arthritis (CIA) as well as other autoimmune diseases that are dependent on inflammatory cells. (ox.ac.uk)
  • Autoimmunity to type II collagen an experimental model of arthritis. (rupress.org)
  • Since homologous type II collagen emulsified in oil without bacterial preparations regularly causes the disease, this new animal model of arthritis represents a unique example of experimentally-inducible autoimmunity to a tissue component. (rupress.org)
  • The Padi4 −/− DBA1J and wild-type mice were immunized with bovine type II collagen (CII) to develop collagen-induced arthritis (CIA). (biomedcentral.com)
  • Methods Collagen-induced arthritis was induced in C57BL/6 or Notch antisense transgenic mice by immunisation with chicken type II collagen (CII). (elsevier.com)
  • Arthritis was induced in mice via intradermal 31 injection of an emulsion containing bovine type II collagen in complete Freund's adjuvant. (unime.it)
  • DBA/1 mice were immunized with type II collagen, and adenovirus vectors were administered by intravenous injection before the clinical onset of collagen-induced arthritis (CIA). (wiley.com)
  • We investigated the influence of concomitant periodontitis on clinical and histopathologic characteristics of T cell-mediated experimental arthritis and evaluated modulation of type II collagen (CII)-reactive Th cell phenotype as a potential mechanism. (unesp.br)
  • Type II collagen arthritis is another model for developing autoimmune arthritis. (ijapr.in)
  • Evaluation of the therapeutic potential of IQ-1S showed that it inhibited matrix metalloproteinase 1 and 3 gene expression induced by interleukin-1 β in human fibroblast-like synoviocytes, and significantly attenuated development of murine collagen-induced arthritis. (aspetjournals.org)
  • The aim of this study is to assess the effectiveness of periodontal treatment at reducing rheumatoid arthritis symptoms, in patients suffering from both periodontitis and rheumatoid arthritis. (isrctn.com)
  • Participants' periodontitis and rheumatoid arthritis symptoms are assessed at the first visit and they are randomly allocated to one of two groups to receive either immediate or delayed periodontal treatment. (isrctn.com)
  • Increasing epidemiologic evidence supports a link between periodontitis and rheumatoid arthritis. (unesp.br)
  • Enbrel, Humira and Remicade) because they effectively prevent bone loss and inflammation in most patients with rheumatoid arthritis. (scienceblog.com)
  • W. Wang, S. Lee, T. Chiueh, and J. Lu, "Molecular and phenotypic characteristics of methicillin-resistant and vancomycin-intermediate Staphylococcus aureus isolates from patients with septic arthritis," Journal of Clinical Microbiology , vol. 47, no. 11, pp. 3617-3623, 2009. (hindawi.com)
  • It recapitulates many of the disease parameters seen in human patients with Lyme arthritis, and thus serves as a model system for the investigation of disease pathogenesis. (prohealth.com)
  • Autologous stem cell transplantation (ASCT) induces long-term drug-free disease remission in patients with juvenile idiopathic arthritis. (sigmaaldrich.com)
  • Technetium-99m labelled polyclonal human IgG scintigraphy before and 26 weeks after initiation of parenteral gold treatment in patients with rheumatoid arthritis. (semanticscholar.org)
  • Orthopaedic surgery of the lower limbs in 49,802 rheumatoid arthritis patients: results from the Swedish National Inpatient Registry during 1987 to 2001. (ki.se)
  • Chlamydia -specific CD8 + T-cells are found in reactive arthritis patients, but the immunogenic epitopes are unknown. (mcponline.org)
  • Evidence to support this theory is found in the fact that there is an abnormally high level of certain types of immunoglobulins in the blood of patients suffering from rheumatoid arthritis. (thefreedictionary.com)
  • In about 75 per cent of patients the onset of rheumatoid arthritis is gradual, with only mild symptoms at the beginning. (thefreedictionary.com)
  • BACKGROUND: It has been widely demonstrated that a quantitative and/or qualitative impairment of regulatory T cells (T(regs)) play a fundamental role in the initiation and persistence of rheumatoid arthritis (RA) in animal models and in patients. (ox.ac.uk)
  • The present study sought to measure the expression of TAGAP in RA patients, CD4+ T cells subsets from healthy humans and in mice with collagen-induced arthritis. (ox.ac.uk)
  • Increased TAGAP expression was observed in RA patients compared to healthy controls, and there were differences in the expression level of TAGAP in the tissues of mice with experimental arthritis. (ox.ac.uk)
  • The experimental immunotherapy is intended to prevent cancer recurrence in patients who have already undergone surgical removal of the tumor. (fiercebiotech.com)
  • Indeed, a Phase I clinical trial for this compound has been completed in rheumatoid arthritis patients. (nature.com)
  • This trial will test the hypothesis that the addition of CF101 , a novel anti-inflammatory agent, will improve the clinical condition of patients with rheumatoid arthritis who still have active joint inflammation despite taking methotrexate for at least 6 months. (clinicaltrials.gov)
  • Interestingly, the isolation of S. aureus from arthritis lesions increases to 80% in joint infections in patients with concurrent rheumatoid arthritis (RA) and in those with diabetes. (biomedcentral.com)
  • Treat-to-target strategies in the management of patients with rheumatoid arthritis (RA) involve intensifying medication as long as low disease activity or remission is not achieved. (nih.gov)
  • Reduction of oxidative stress marker levels by anti-TNF-alpha antibody, infliximab, in patients with rheumatoid arthritis. (nih.gov)
  • Evidence from PEAC (see above), in which synovial biopsies have been taken from patients with early arthritis, indicate that there are at least three distinct histo-morphological subtypes. (qmul.ac.uk)
  • Maximising Therapeutic Utility in Rheumatoid Arthritis ( MATURA ) is an ambitious research project jointly funded by MRC and Versus Arthritis to identify and test biomarkers predictive of response to therapy in rheumatoid arthritis (RA), thereby allowing the stratification of patients into groups according to the therapies that are most likely to be effective. (qmul.ac.uk)
  • Preliminary data suggest that up-regulation of IL-17 and the ThH17 pathway occurs in patients with rheumatoid arthritis (RA) who have been treated with anti-tumor necrosis factor- alpha (anti-TNFα) therapy but demonstrate an incomplete clinical response. (qmul.ac.uk)
  • Here we utilized experimental models of autoimmune arthritis and uveitis, and PBMCs from Blau syndrome patients to dissect a T cell-specific role for NOD2 in uveitis. (acrabstracts.org)
  • Patients with HIV have an increased risk of developing reactive arthritis as well. (wikipedia.org)
  • The antimicrobial peptide HBD-2 and the Toll-like receptors-2 and -4 are induced in synovial membranes in case of septic arthritis," Virchows Archiv , vol. 454, no. 6, pp. 685-694, 2009. (hindawi.com)
  • Cortistatin exerted its effects on synovial cells through both somatostatin and ghrelin receptors, showing a higher effect than both peptides protecting against experimental arthritis. (pubmedcentralcanada.ca)
  • Rheumatoid arthritis (RA) is a common autoimmune disease characterized by chronic polyarticular synovial inflammation. (ki.se)
  • Rheumatoid arthritis is a chronic systemic disease, which is characterized by chronic inflammation in the synovial tissue. (clinicaltrials.gov)
  • Arthritis of joints involves inflammation of the synovial membrane. (wikipedia.org)
  • Thereafter, silicosis was confirmed via flow cytometry and arthritis was evaluated performing knee and paw histology. (biomedcentral.com)
  • The aim of this study was to evaluate the therapeutic potential of CARN in rat adjuvant arthritis, in the model of carrageenan induced hind paw edema (CARA), and also in primary culture of chondrocytes under H 2 O 2 injury. (hindawi.com)
  • These results establish DN-TNFs as the first selective inhibitors of solTNF, demonstrate that inflammation in mouse arthritis models is primarily driven by solTNF, and suggest that the maintenance of tmTNF activity may improve the therapeutic index of future anti-inflammatory agents. (jimmunol.org)
  • To investigate the therapeutic influence of ibuprofen and Boigor-10 on experimentally induced mice with rheumatoid arthritis (RA). (scirp.org)
  • The therapeutic activity of low-dose irradiation on experimental arthritis depends on the induction of endogenous regulatory T cell activity. (ox.ac.uk)
  • The association of this antibody to other drugs interfering at other levels in rheumatoid arthritis may open a new therapeutic window. (unipg.it)
  • Eicosanoids, such as PGE2 and LTB4, are powerful regulators of inflammatory responses and thus may be important mediators of Lyme arthritis. (prohealth.com)
  • This suppression of arthritis was associated with significant alterations in the T cell proliferative and cytokine responses as well as the antibody response against the disease-related antigen, mycobacterial heat-shock protein 65 (Bhsp65). (harvard.edu)
  • This is, to our knowledge, the first endogenously processed epitope involved in HLA-B27-restricted responses against C. trachomatis in reactive arthritis. (mcponline.org)
  • Regulation of pathogenic IL-17 responses in collagen-induced arthritis: roles of endogenous interferon-gamma and IL-4. (mcw.edu)
  • Members of the suppressor of cytokine signaling (SOCS) family are key negative intracellular regulators of cytokine and growth factor responses, including those that regulate immune responses in autoimmune disorders, such as rheumatoid arthritis (RA). (wiley.com)
  • Scientists from the Vaccine and Infectious Disease Organization-International Vaccine Centre at the University of Saskatchewan and Temple University have demonstrated that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals. (news-medical.net)
  • DBA/1J mice with collagen‐induced arthritis were treated with cortistatin after the onset of disease, and the clinical score and joint histopathology were evaluated. (pubmedcentralcanada.ca)
  • 3. The pharmaceutical composition of claim 1, wherein said arthritic disease is degenerative arthritis or rheumatic arthritis. (freepatentsonline.com)
  • acute rheumatic arthritis swelling, tenderness, and redness of many joints of the body, accompanying rheumatic fever. (thefreedictionary.com)
  • Mounting evidence from clinical observations in humans and experimental studies in rodents suggests that paracrine signaling by solTNF is associated with chronic inflammation ( 6 , 7 ), whereas juxtacrine signaling by tmTNF plays an essential role in resolving inflammation ( 8 , 9 , 10 ) and maintaining immunity to pathogens including Listeria monocytogenes ( 11 , 12 ) and Mycobacterium tuberculosis ( 13 , 14 , 15 , 16 ). (jimmunol.org)
  • IL-6 prevents development of sub-chronic inflammation without modifying the acute inflammation in zymosan-induced-arthritis (ZIA). (biomedcentral.com)
  • Possible candidate genes for (sub)chronic inflammation or destructive arthritis were defined by two-parameter and cluster analysis of the expression profile. (biomedcentral.com)
  • The aim of this study was to evaluate the effect of pegylated PSL (PEG-PSL) on chronic inflammation of collagen induced arthritis (CIA) in DBA/1J mice. (biomedcentral.com)
  • Krill oil reduces symptoms of chronic inflammation and arthritis. (greenmedinfo.com)
  • Intermittent active motion versus immobilization in the treatment of Staphylococcus aureus -induced arthritis in a rabbit model," Journal of Children's Orthopaedics , vol. 2, no. 6, pp. 491-495, 2008. (hindawi.com)
  • Interleukin-17A during local and systemic Staphylococcus aureus -induced arthritis in mice," Infection and Immunity , vol. 78, no. 9, pp. 3783-3790, 2010. (hindawi.com)
  • Impact of interferon-gamma receptor deficiency on experimental Staphylococcus aureus septicemia and arthritis. (jimmunol.org)
  • The role of IFN-gamma in the regulation of host resistance of Staphylococcus aureus was studied using IFN-gamma receptor-deficient (IFN-gamma R-/-) mice in a model of S. aureus-induced septicemia and arthritis. (jimmunol.org)
  • Septic arthritis is an inflammatory disease of the joints that is started by an infection whose most common agent is Staphylococcus aureus . (bvsalud.org)
  • The findings of bacterial antigens in the joint and persistent triggering infection elsewhere in the body are thought to be important in the pathogenesis of reactive arthritis (ReA). (nih.gov)
  • Chlamydia trachomatis triggers reactive arthritis, a spondyloarthropathy linked to the human major histocompatibility complex molecule HLA-B27, through an unknown mechanism that might involve molecular mimicry between chlamydial and self-derived HLA-B27 ligands. (mcponline.org)
  • It is a very common pathogen and one frequently inducing reactive arthritis (ReA) 1 ( 1 ). (mcponline.org)
  • The term "reactive arthritis" is strongly preferred and increasingly used as a substitute for this designation because Hans Conrad Julius Reiter was not the first to describe the syndrome, his conclusions regarding its pathogenesis were incorrect, and because he committed war crimes as a Nazi at Buchenwald concentration camp during World War II. (wikipedia.org)
  • Arthritis occurring alone following sexual exposure or enteric infection is also known as reactive arthritis. (wikipedia.org)
  • The clinical pattern of reactive arthritis commonly consists of an inflammation of fewer than five joints which often includes the knee or sacroiliac joint. (wikipedia.org)
  • Reactive arthritis is an RF-seronegative, HLA-B27-linked arthritis often precipitated by genitourinary or gastrointestinal infections. (wikipedia.org)
  • Because common systems involved include the eye, the urinary system, and the hands and feet, one clinical mnemonic in reactive arthritis is "Can't see, can't pee, can't climb a tree. (wikipedia.org)
  • The presence of keratoderma blennorrhagica is diagnostic of reactive arthritis in the absence of the classical triad. (wikipedia.org)
  • Ocular involvement (mild bilateral conjunctivitis) occurs in about 50% of men with urogenital reactive arthritis syndrome and about 75% of men with enteric reactive arthritis syndrome. (wikipedia.org)
  • Eye involvement typically occurs early in the course of reactive arthritis, and symptoms may come and go. (wikipedia.org)
  • Dactylitis, or "sausage digit", a diffuse swelling of a solitary finger or toe, is a distinctive feature of reactive arthritis and other peripheral spondylarthritides but can also be seen in polyarticular gout and sarcoidosis. (wikipedia.org)
  • Treatment with estradiol potently inhibits experimental autoimmune arthritis. (sigmaaldrich.com)
  • In the current study, we examined whether this peptide inhibits the proliferation of rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS) or not. (termedia.pl)
  • On the other hand, adenoviral mediated gene transfer of IL-4 completely inhibits progression into the destructive phase in collagen-induced arthritis (CIA). (biomedcentral.com)
  • Upholding the T cell immune-regulatory function of CD31 inhibits the formation of T/B immunological synapses in vitro and attenuates the development of experimental autoimmune arthritis in vivo. (mcw.edu)
  • Joint inflammation in experimental arthritis is preceded by TNFa-dependent infiltration of the synovium by mesenchymal cells. (ox.ac.uk)
  • Therefore, changes in cellular zinc levels in specific immune cells may influence inflammatory autoimmune diseases, such as rheumatoid arthritis (RA). (nature.com)
  • We demonstrated that ZIP8 was specifically upregulated in CD4 + T cells that infiltrated the inflamed joint and that ZIP8 deficiency in CD4 + T cells abrogated collagen-induced arthritis. (nature.com)
  • Interleukin-17-producing T helper cells (Th17) are key players in several autoimmune diseases, particularly in rheumatoid arthritis. (sigmaaldrich.com)
  • The aim of this study was to investigate the effects of estrogen on Th17 cells in experimental arthritis. (sigmaaldrich.com)
  • E2-treated mice with established CIA showed reduced severity of arthritis and fewer Th17 cells in joints compared with controls. (sigmaaldrich.com)
  • This is the first study in which the effects of E2 on Th17 cells have been characterized in experimental autoimmune arthritis. (sigmaaldrich.com)
  • We report that E2 treatment results in an increase of Th17 cells in lymph nodes during the early phase of arthritis development, but leads to a decrease of Th17 in joints during established arthritis. (sigmaaldrich.com)
  • DN-TNFs blocked solTNF activity in human and mouse cells, a human blood cytokine release assay, and two mouse arthritis models. (jimmunol.org)
  • The aim of this study was to investigate modulation of T cell immunity for the treatment of experimental arthritis, via enhanced expression of SOCS-3 in splenic antigen-presenting cells (APCs) obtained after intravenous injection of adenovirus encoding SOCS-3. (wiley.com)
  • The underlying hypothesis is that autologous bone marrow-derived mesenchymal and specific populations of stem cells has anti-inflammatory and regenerative effects and thus potentially alleviates the progression of rheumatoid arthritis. (clinicaltrials.gov)
  • Lymphopenic Rag1 -/- mice were reconstituted with NOD2 -/- or NOD2 +/+ (WT) CD4+ T cells and arthritis or uveitis was induced. (acrabstracts.org)
  • Lymphopenic recipients of NOD2-deficient T cells developed significantly worse arthritis and uveitis, implicating T cell-intrinsic NOD2 in suppression of disease. (acrabstracts.org)
  • NOD2 -/- mice) results in a "gain-of-function" in the ability of T cells to produce IL-17 and cause arthritis and uveitis. (acrabstracts.org)
  • Septic arthritis (SA), also called infectious arthritis, is an inflammatory disease of the joints that is started by an infectious agent. (biomedcentral.com)
  • The cause of rheumatoid arthritis is unknown and it is doubtful that there is one specific cause. (thefreedictionary.com)
  • While the cause of rheumatoid arthritis is not clear, it is believed to involve a combination of genetic and environmental factors. (wikipedia.org)
  • Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that primarily affects joint tissues. (nature.com)
  • The most common form of arthritis, it develops over time following initial joint injuries or just as a result of aging. (eurekalert.org)
  • The common ground between arthritis and dentistry: a common site of arthritic pain is the jaw joint. (eurekalert.org)
  • METHODS Adjuvant arthritis was induced in the ankle joint of the left hind foot by injection of Mycobacterium butyricum in Freund's incomplete adjuvant in the foot pad. (semanticscholar.org)
  • Firstly, the pathophysiological background of joint destruction was investigated at a cellular level in experimental arthritis. (ki.se)
  • RANKL promotes osteoclast differentiation and plays an important role in the joint destruction seen in arthritis. (biomedcentral.com)
  • Degenerative arthritis, one of representative osteo-joint diseases is chronic arthritis. (freepatentsonline.com)
  • Dorsal Root Ganglion Field Stimulation Prevents Inflammation and Joint Damage in a Rat Model of Rheumatoid Arthritis. (mcw.edu)
  • juvenile rheumatoid arthritis rheumatoid arthritis in children under age 16, characterized by swelling, tenderness, and pain, involving one joint or several joints and lasting more than six weeks. (thefreedictionary.com)
  • Arthritis of the knee is the most common type of joint inflammatory disorder and it is associated with pain and inflammation of the joint capsule. (springer.com)
  • However, lung inflammation did not lead to an increase in the incidence of arthritis, nor did it exacerbate the macroscopic or histologic joint scores. (biomedcentral.com)
  • The most important risk factor for SA is preexisting joint pathologies, especially rheumatoid arthritis or prosthetic joint surgery. (biomedcentral.com)
  • Early-stage research has found that a new gene therapy can nearly eliminate arthritis pain, and significantly reduce long-term damage to the affected joints, according to a study published today in the journal Arthritis and Rheumatism. (eurekalert.org)
  • Inhibition of clinical arthritis coincided with reduction of inflammatory cell infiltration in the joints, liver and muscle. (prohealth.com)
  • Arthritis is considered one of the major causes of chronic disability in the elderly population, affecting diarthrodial joints. (springer.com)
  • Rheumatoid arthritis (RA) is a chronic autoimmune disorder that primarily affects joints. (clinicaltrials.gov)
  • The arthritis may be "additive" (more joints become inflamed in addition to the primarily affected one) or "migratory" (new joints become inflamed after the initially inflamed site has already improved). (wikipedia.org)
  • Rheumatoid arthritis (RA) is a long-term autoimmune disorder that primarily affects joints. (wikipedia.org)
  • The term rheumatoid arthritis is based on the Greek for watery and inflamed joints. (wikipedia.org)
  • Arthritis & Rheumatism, 65: 660-670. (wiley.com)
  • TGP has been used in rheumatoid arthritis therapy for many years. (biomedcentral.com)
  • The search for less toxic non-pharmacological alternatives agents in arthritis management suffers from lack of interest and funding, but low-level laser therapy (LLLT) is about to be taken more seriously by clinicians. (springer.com)
  • A subtype is deemed actionable if there is both a CLIA-approved assay to determine whether a given tumor fits that classification, and at least one FDA-approved or experimental targeted therapy with potential efficacy for that subtype. (medindia.net)
  • While much progress has been made in defining components of the immune response to Borrelia infection, an overall understanding of the host response leading to arthritis resistance or susceptibility remains elusive. (prohealth.com)
  • The drug was administered orally at a dose of 3, 10 and 30 mg/kg, starting shortly before experimental infection of the mice. (prohealth.com)
  • Prednisolone was ineffective when application was initiated after arthritis was fully developed, i.e., 22 days after infection. (prohealth.com)
  • Activation of macrophages in an experimental rat model of arthritis induced by Erysipelothrix rhusiopathiae infection. (harvard.edu)
  • Porphyromonas gingivalis oral infection exacerbates the development and severity of collagen-induced arthritis. (mcw.edu)
  • Severity of arthritis was monitored by clinical and histological scores, and in vivo non-invasive near-infrared fluorescence (NIRF) images. (elsevier.com)
  • The importance of IL-10 in reducing the severity of arthritis was clearly shown, but curiously IL-10 also seemed to promote arthritis as IL-10 deficiency protected against antibody-transfer induced arthritis. (lu.se)
  • An investigational drug in clinical trials for rheumatoid arthritis prevents a common, life-threatening side effect of stem cell transplants, new research from Washington University School of Medicine in St. Louis shows. (eurekalert.org)
  • At times it is accompanied by systemic manifestations such as spiking fever, transient rash on the trunk and limbs, hepatosplenomegaly, generalized lymphadenopathy, and anemia, in which case it is known as Still's disease or systemic onset juvenile rheumatoid arthritis . (thefreedictionary.com)
  • This form of arthritis strikes during the most productive years of adulthood, with onset in the majority of cases between the ages of 20 and 40. (thefreedictionary.com)
  • METHODS: Low-dose irradiation was used before the induction of arthritis or at the onset of disease. (ox.ac.uk)
  • GSH levels significantly increased in Group III and IV than Group V. SOD activity of Group IV was higher than Group III and V. TNF-alpha levels were significantly lower in Group IV and V. LC and alpha-LA seemed to have protective effects against oxidative damage in adjuvant arthritis model. (curehunter.com)
  • This study was undertaken to further unravel the immunologic mechanisms underlying ASCT by using a mouse model of proteoglycan-induced arthritis (PGIA). (sigmaaldrich.com)
  • We report here a traditional Chinese medicine-based herbal formula, Huo luo xiao ling dan (HLXL), which has potent antiarthritic activity as validated in the rat adjuvant-induced arthritis (AA) model. (harvard.edu)
  • OBJECTIVES Liposomes sterically stabilised with polyethylene glycol (PEG) labelled with technetium-99m were tested for their ability to image adjuvant arthritis in a rat model. (semanticscholar.org)
  • 1) Collagen-induced arthritis (CIA) is a well-established animal model of arthritis with differential susceptibility in various rat strains. (ki.se)
  • Objective: To test the hypothesis that Notch signalling plays a role in the pathogenesis of rheumatoid arthritis (RA) and to determine whether pharmacological inhibition of Notch signalling with γ-secretase inhibitors can ameliorate the RA disease process in an animal model. (elsevier.com)
  • OBJECTIVES: (1) To test the ability of low-intensity myeloablation mediated T(reg) activation to prevent and/or to treat experimental arthritis using the collagen-induced arthritis (CIA) model and (2) to clarify the role of T(reg) in mediating the beneficial effect. (ox.ac.uk)
  • The experimental model showed an expression of severe arthritis after the booster. (biomedcentral.com)
  • For the identification of genes regulating neuroinflammation we used a rat model of MS, myelin oligodendrocyte glycoprotein (MOG)-induced experimental autoimmune encephalomyelitis (EAE), and carried out a linkage analysis in an advanced intercross line (AIL). (cdc.gov)
  • We therefore set out to investigate the effect of silicosis - a model for chronic lung inflammation - on collagen-induced arthritis, a murine model for RA. (biomedcentral.com)
  • The vaccine ingredient Freund's adjuvant has been used to induce monoarticular arthritis in an animal model. (greenmedinfo.com)
  • By this model, nearly 100% arthritis can be achieved. (ijapr.in)
  • Inflammation has been regarded as a cardinal player in the pathogenesis of arthritis. (karger.com)
  • These results have shed some light on the pathogenesis of arthritis and sialadenitis but further knowledge is needed to understand these complex diseases. (lu.se)
  • Peptidylarginine deiminase type 4 (PADI4) has been identified as a susceptibility gene for rheumatoid arthritis (RA) by genome-wide association studies. (biomedcentral.com)
  • Genome-wide association studies have identified various susceptibility variants and loci associated with incidence of rheumatoid arthritis (RA) in different populations. (ox.ac.uk)
  • This study contributes to the understanding of the role of estrogen in the development of autoimmune arthritis and opens up new fields for research concerning the sex bias in autoimmune disease. (sigmaaldrich.com)
  • Rheumatoid arthritis (RA) is a systemic autoimmune disease which manifests predominantly as a chronic polyarthritis. (biomedcentral.com)
  • Ankle/hindfoot arthrodesis in rheumatoid arthritis improves kinematics and kinetics of the knee and hip: a prospective gait analysis study. (ki.se)
  • Genetic variants of CC chemokine genes in experimental autoimmune encephalomyelitis, multiple sclerosis and rheumatoid arthritis. (cdc.gov)