Arterivirus
Arteritis Virus, Equine
Porcine respiratory and reproductive syndrome virus
Nidovirales
Arteriviridae
Lactate dehydrogenase-elevating virus
Porcine Reproductive and Respiratory Syndrome
A syndrome characterized by outbreaks of late term abortions, high numbers of stillbirths and mummified or weak newborn piglets, and respiratory disease in young unweaned and weaned pigs. It is caused by PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS. (Radostits et al., Veterinary Medicine, 8th ed, p1048)
RNA Replicase
Open Reading Frames
Viral Nonstructural Proteins
Virus Replication
Horses
Cricetinae
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Arterivirus discontinuous mRNA transcription is guided by base pairing between sense and antisense transcription-regulating sequences. (1/55)
To generate an extensive set of subgenomic (sg) mRNAs, nidoviruses (arteriviruses and coronaviruses) use a mechanism of discontinuous transcription. During this process, mRNAs are generated that represent the genomic 5' sequence, the so-called leader RNA, fused at specific positions to different 3' regions of the genome. The fusion of the leader to the mRNA bodies occurs at a short, conserved sequence element, the transcription-regulating sequence (TRS), which precedes every transcription unit in the genome and is also present at the 3' end of the leader sequence. Here, we have used site-directed mutagenesis of the infectious cDNA clone of the arterivirus equine arteritis virus to show that sg mRNA synthesis requires a base-pairing interaction between the leader TRS and the complement of a body TRS in the viral negative strand. Mutagenesis of the body TRS of equine arteritis virus RNA7 reduced sg RNA7 transcription severely or abolished it completely. Mutations in the leader TRS dramatically influenced the synthesis of all sg mRNAs. The construction of double mutants in which a mutant leader TRS was combined with the corresponding mutant RNA7 body TRS resulted in the specific restoration of mRNA7 synthesis. The analysis of the mRNA leader-body junctions of a number of mutants with partial transcriptional activity provided support for a mechanism of discontinuous minus-strand transcription that resembles similarity-assisted, copy-choice RNA recombination. (+info)Gill-associated virus of Penaeus monodon prawns: an invertebrate virus with ORF1a and ORF1b genes related to arteri- and coronaviruses. (2/55)
A 20089 nucleotide (nt) sequence was determined for the 5' end of the (+)-ssRNA genome of gill-associated virus (GAV), a yellow head-like virus infecting Penaeus monodon prawns. Clones were generated from a approximately 22 kb dsRNA purified from lymphoid organ total RNA of GAV-infected prawns. The region contains a single gene comprising two long overlapping open reading frames, ORF1a and ORF1b, of 4060 and 2646 amino acids, respectively. The ORFs are structurally related to the ORF1a and ORF1ab polyproteins of coronaviruses and arteriviruses. The 99 nt overlap between ORF1a and ORF1b contains a putative AAAUUUU 'slippery' sequence associated with -1 ribosomal frameshifting. A 131 nt stem-loop with the potential to form a complex pseudoknot resides 3 nt downstream of this sequence. Although different to the G/UUUAAAC frameshift sites and 'H-type' pseudoknots of nidoviruses, in vitro transcription/translation analysis demonstrated that the GAV element also facilitates read-through of the ORF1a/1b junction. As in coronaviruses, GAV ORF1a encodes a 3C-like cysteine protease domain located between two hydrophobic regions. However, its sequence suggests some structural relationship to the chymotrypsin-like serine proteases of arteriviruses. ORF1b encodes homologues of the 'SDD' polymerase, which among (+)-RNA viruses is unique to nidoviruses, as well as metal-ion-binding and helicase domains. The presence of a dsRNA replicative intermediate and ORF1a and ORF1ab polyproteins translated by a-1 frameshift suggests that GAV represents the first invertebrate member of the Order NIDOVIRALES: (+info)The arterivirus replicase is the only viral protein required for genome replication and subgenomic mRNA transcription. (3/55)
Equine arteritis virus (EAV) (ARTERIVIRIDAE:) encodes several structural proteins. Whether any of these also function in viral RNA synthesis is unknown. For the related mouse hepatitis coronavirus (MHV), it has been suggested that the nucleocapsid protein (N) is involved in viral RNA synthesis. As described for MHV, we established that the EAV N protein colocalizes with the viral replication complex, suggesting a role in RNA synthesis. Using an infectious cDNA clone, point mutations and deletions were engineered in the EAV genome to disrupt the expression of each of the structural genes. All structural proteins, including N, were found to be dispensable for genome replication and subgenomic mRNA transcription. We also constructed a mutant in which translation of the intraleader ORF was disrupted. This mutant had a wild-type phenotype, indicating that, at least in cell culture, the product of this ORF does not play a role in the EAV replication cycle. (+info)Biochemical characterization of the equine arteritis virus helicase suggests a close functional relationship between arterivirus and coronavirus helicases. (4/55)
The arterivirus equine arteritis virus nonstructural protein 10 (nsp10) has previously been predicted to contain a Zn finger structure linked to a superfamily 1 (SF1) helicase domain. A recombinant form of nsp10, MBP-nsp10, was produced in Escherichia coli as a fusion protein with the maltose-binding protein. The protein was partially purified by affinity chromatography and shown to have ATPase activity that was strongly stimulated by poly(dT), poly(U), and poly(dA) but not by poly(G). The protein also had both RNA and DNA duplex-unwinding activities that required the presence of 5' single-stranded regions on the partial-duplex substrates, indicating a 5'-to-3' polarity in the unwinding reaction. Results of this study suggest a close functional relationship between the arterivirus nsp10 and the coronavirus helicase, for which NTPase and duplex-unwinding activities were recently demonstrated. In a number of biochemical properties, both arterivirus and coronavirus SF1 helicases differ significantly from the previously characterized RNA virus SF1 and SF2 enzymes. Thus, the combined data strongly support the idea that nidovirus helicases may represent a separate group of RNA virus-encoded helicases with distinct properties. (+info)Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole. (5/55)
Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breeding industries. The arterivirus replicase gene encodes two large precursor polyproteins that are processed by the viral main proteinase nonstructural protein 4 (nsp4). The three-dimensional structure of the 21-kDa nsp4 from the arterivirus prototype equine arteritis virus has been determined to 2.0 A resolution. Nsp4 adopts the smallest known chymotrypsin-like fold with a canonical catalytic triad of Ser-120, His-39, and Asp-65, as well as a novel alpha/beta C-terminal extension domain that may play a role in mediating protein-protein interactions. In different copies of nsp4 in the asymmetric unit, the oxyanion hole adopts either a collapsed inactive conformation or the standard active conformation, which may be a novel way of regulating proteolytic activity. (+info)Chimeric arteriviruses generated by swapping of the M protein ectodomain rule out a role of this domain in viral targeting. (6/55)
Arteriviruses are enveloped, positive-strand RNA viruses for which the two major envelope proteins GP(5) and M occur as disulfide-linked heterodimers. These were assumed to serve the viral targeting functions, but recent ectodomain swapping studies with equine arteritis virus (EAV) indicate that the GP(5) protein does not determine arteriviral tropism. Here, we focused on the short, 13- to 18-residue ectodomain of the M protein. Using an infectious cDNA clone of the Lelystad virus isolate of porcine reproductive and respiratory syndrome virus (PRRSV), we substituted the genomic sequence encoding the M ectodomain by that of murine lactate dehydrogenase-elevating virus, EAV, and the US PRRSV-isolate, VR2332. Viable viruses with a chimeric M protein were obtained in all three cases, but for the latter two only after removal of the genomic overlap between the M and GP(5) genes. Characterization of the chimeric viruses revealed that they could be distinguished immunologically from wild-type virus, that they were genetically stable in vitro, but that they were impaired in their growth, reaching lower titers than the parental virus. The latter appeared to be due to an increased particle-to-infectivity ratio of the chimeric virus particles. Interestingly, the chimeric viruses had retained their ability to infect porcine cells and had not acquired tropism for cells susceptible to the viruses from which the foreign ectodomains were derived. We conclude that the surface structures composed by the arterivirus M and GP(5) ectodomains do not determine viral tropism. (+info)Quantitative assessment of the effect of uracil-DNA glycosylase on amplicon DNA degradation and RNA amplification in reverse transcription-PCR. (7/55)
Although PCR and RT-PCR provided a valuable approach for detection of pathogens, the high level of sensitivity of these assays also makes them prone to false positive results. In addition to cross-contamination with true positive samples, false positive results are also possible due to "carry-over" contamination of samples with amplicon DNA generated by previous reactions. To reduce this source of false positives, amplicon generated by reactions in which dUTP was substituted for dTTP can be degraded by uracil DNA glycosylase (UNG). UNG does not degrade RNA but will cleave contaminating uracil-containing DNA while leaving thymine-containing DNA intact. The availability of heat-labile UNG makes use of this approach feasible for RT-PCR. In this study, real-time RT-PCR was used to quantify UNG degradation of amplicon DNA and the effect of UNG on RNA detection. Using the manufacturers' recommended conditions, complete degradation of DNA was not observed for samples containing 250 copies of amplicon DNA. Doubling the UNG concentration resulted in degradation of the two lowest concentrations of DNA tested, but also resulted in an increase of 1.94 cycles in the CT for RNA detection. To improve DNA degradation while minimizing the effect on RNA detection, a series of time, temperature and enzyme concentrations were evaluated. Optimal conditions were found to be 0.25 U UNG per 25 microl reaction with a 20 min, 30 degrees C incubation prior to RT-PCR. Under these conditions, high concentrations of amplicon DNA could be degraded while the CT for RNA detection was increased by 1.2 cycles. (+info)An RNA pseudoknot in the 3' end of the arterivirus genome has a critical role in regulating viral RNA synthesis. (8/55)
In the life cycle of plus-strand RNA viruses, the genome initially serves as the template for both translation of the viral replicase gene and synthesis of minus-strand RNA and is ultimately packaged into progeny virions. These various processes must be properly balanced to ensure efficient viral proliferation. To achieve this, higher-order RNA structures near the termini of a variety of RNA virus genomes are thought to play a key role in regulating the specificity and efficiency of viral RNA synthesis. In this study, we have analyzed the signals for minus-strand RNA synthesis in the prototype of the arterivirus family, equine arteritis virus (EAV). Using site-directed mutagenesis and an EAV reverse genetics system, we have demonstrated that a stem-loop structure near the 3' terminus of the EAV genome is required for RNA synthesis. We have also obtained evidence for an essential pseudoknot interaction between the loop region of this stem-loop structure and an upstream hairpin residing in the gene encoding the nucleocapsid protein. We propose that the formation of this pseudoknot interaction may constitute a molecular switch that could regulate the specificity or timing of viral RNA synthesis. This hypothesis is supported by the fact that phylogenetic analysis predicted the formation of similar pseudoknot interactions near the 3' end of all known arterivirus genomes, suggesting that this interaction has been conserved in evolution. (+info)
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Equine arterivirus serine peptidase
... in arterivirus replicase translation products ORF1a and ORF1ab In the equine arterivirus (EAV), the replicase gene is ... Equine+arterivirus+serine+peptidase at the US National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology v t ... Equine arterivirus serine peptidase (EC 3.4.21.114) is an enzyme. This enzyme catalyses the following chemical reaction ... "The arterivirus nsp4 protease is the prototype of a novel group of chymotrypsin-like enzymes, the 3C-like serine proteases". ...
Nidoviral papain-like protease
This prediction was later confirmed by in vitro experiments for a number of coronavirus and arterivirus PLP domains, including ... In addition to deubiquitinating activity, coronavirus and arterivirus PLP domains have been identified as deISGylase enzymes, ... Snijder, Eric J.; Kikkert, Marjolein; Fang, Ying (1 October 2013). "Arterivirus molecular biology and pathogenesis". Journal of ... "Arterivirus Subgenomic mRNA Synthesis and Virion Biogenesis Depend on the Multifunctional nsp1 Autoprotease". Journal of ...
Equine viral arteritis
EVA is caused by an arterivirus called equine arteritis virus (EAV). Arteriviruses are small, enveloped, animal viruses with an ... As well as equine arteritis virus the Arterivirus family includes porcine reproductive and respiratory syndrome virus (PRRSV), ... "Zn2+ Inhibits Coronavirus and Arterivirus RNA Polymerase Activity In Vitro and Zinc Ionophores Block the Replication of These ...
Torovirus
The recent molecular analysis of the virus revealed its similarities with Arterivirus and coronaviruses, which led to the ... inclusion of the Torovirus along with the Arterivirus in the previously monogeneric Coronaviridae. At present, toroviruses are ... Torovirus and Arterivirus genera. Archives of virology, 135(1-2), 227-237. https://doi.org/10.1007/BF01309782 Ivanov K.A., ...
Arteriviridae
"Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019". Emerg Infect Dis. 27 (2 ...
Virology
In 1957 equine arterivirus and the cause of Bovine virus diarrhoea (a pestivirus) were discovered. In 1963 the hepatitis B ...
Betaarterivirus suid 1
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Chloroquine
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History of virology
... equine arterivirus was discovered. In the 1950s, improvements in virus isolation and detection methods resulted in the ...
List of MeSH codes (B04)
... arterivirus MeSH B04.909.777.500.080.500.100 - arteritis virus, equine MeSH B04.909.777.500.080.500.500 - lactate dehydrogenase ... arterivirus MeSH B04.820.504.080.100.100 - arteritis virus, equine MeSH B04.820.504.080.100.500 - lactate dehydrogenase- ...
List of MeSH codes (C02)
... arterivirus infections MeSH C02.782.600.100.700 - porcine reproductive and respiratory syndrome MeSH C02.782.600.550 - ...
List of EC numbers (EC 3)
... equine arterivirus serine peptidase EC 3.4.21.115: infectious pancreatic necrosis birnavirus Vp4 peptidase EC 3.4.21.116: ... equine arterivirus serine peptidase EC 3.4.21.115: infectious pancreatic necrosis birnavirus Vp4 peptidase EC 3.4.21.116: ...
Arterivirus molecular biology and pathogenesis - PubMed
Arterivirus molecular biology and pathogenesis Eric J Snijder 1 , Marjolein Kikkert 1 , Ying Fang 2 3 ... Arterivirus molecular biology and pathogenesis Eric J Snijder et al. J Gen Virol. 2013 Oct. ... Structural Biology of the Arterivirus nsp11 Endoribonucleases. Zhang M, Li X, Deng Z, Chen Z, Liu Y, Gao Y, Wu W, Chen Z. Zhang ... Biogenesis and architecture of arterivirus replication organelles. van der Hoeven B, Oudshoorn D, Koster AJ, Snijder EJ, ...
Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019 - Volume 27, Number 2...
Vanmechelen B, Vergote V, Laenen L, Koundouno FR, Bore JA, Wada J, et al. Expanding the arterivirus host spectrum: Oliviers ... Arterivirus molecular biology and pathogenesis. J Gen Virol. 2013;94:2141-63. DOIPubMedGoogle Scholar ... Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019 On This Page ... Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019. Emerging Infectious ...
Arterivirus. Medical search
arterivirus , Journal of Virology. Evidence for Gene Duplication during Arterivirus Evolution E. K. Godeny, A. A. F. de Vries, ... The arterivirus nsp1 region contains a tandem of papain-like autoprotease domains (PCP α and PCP β ), and the arterivirus PCP α ... Equine arterivirus serine peptidase. ... in arterivirus replicase translation products ORF1a and ORF1ab In the equine ... ASMscience , The Arterivirus Replicas. This chapter focuses on the arterivirus proteins that are involved in genome replication ...
Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019 - Volume 27, Number 2...
Vanmechelen B, Vergote V, Laenen L, Koundouno FR, Bore JA, Wada J, et al. Expanding the arterivirus host spectrum: Oliviers ... Arterivirus molecular biology and pathogenesis. J Gen Virol. 2013;94:2141-63. DOIPubMedGoogle Scholar ... Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019 On This Page ... Novel Arterivirus Associated with Outbreak of Fatal Encephalitis in European Hedgehogs, England, 2019. Emerging Infectious ...
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MeSH Browser
Arterivirus Preferred Term Term UI T053868. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1994). ... Arterivirus Preferred Concept UI. M0027204. Related Numbers. txid38143. Scope Note. A genus of the family ARTERIVIRIDAE, in the ... Arterivirus [B04.820.578.500.080.500] * Equartevirus [B04.820.578.500.080.500.100] * Lactate dehydrogenase-elevating virus [ ... infection = ARTERIVIRUS INFECTIONS. Scope Note. A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species ...
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MeSH Browser
Arterivirus Preferred Term Term UI T053868. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1994). ... Arterivirus Preferred Concept UI. M0027204. Related Numbers. txid38143. Scope Note. A genus of the family ARTERIVIRIDAE, in the ... Arterivirus [B04.820.578.500.080.500] * Equartevirus [B04.820.578.500.080.500.100] * Lactate dehydrogenase-elevating virus [ ... infection = ARTERIVIRUS INFECTIONS. Scope Note. A genus of the family ARTERIVIRIDAE, in the order NIDOVIRALES. The type species ...
PRRSV1 and PRRSV2 viruses taxonomy | PRRS Control
Tian D, Wei Z, Zevenhoven-Dobbe JC, Liu R, Tong G, Snijder EJ, Yuan S. Arterivirus minor envelope proteins are a major ... Heterodimerization of the two major proteins is essential for arterivirus infectivity. J Virol. 2003, 77:97-104. Snijder EJ, ... porcine arterivirus). In: 10th ed. Diseases of swine, Ed. Wiley-Blackwell. 2012, 31:463-86. ... Kikkert M, Fang Y. Arterivirus molecular biology and pathogenesis. J Gen Virol. 2013, 94:2141-63. ...
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Marshall, V. A., Labo, N., Hao, X. P., Holdridge, B., Thompson, M., Miley, W., Brands, C., Coalter, V., Kiser, R., Anver, M., Golubeva, Y., Warner, A., Jaffe, E. S., Piatak, M., Wong, S. W., Ohlen, C., MacAllister, R., Smedley, J., Deleage, C., Del Prete, G. Q. & 3 others, Lifson, J. D., Estes, J. D. & Whitby, D., Jul 2018, In: PLoS pathogens. 14, 7, e1007130.. Research output: Contribution to journal › Article › peer-review ...
Genus5
- The PRRS virus is an enveloped RNA virus in the genus Arterivirus, classified in the virus family, Arteriviridae. (iastate.edu)
- PRRSV is an RNA virus and belongs to the order Nidovirales, family Arteriviridae and the genus Arterivirus. (loinc.org)
- Porcine reproductive and respiratory syndrome (PRRS), caused by PRRS virus (PRRSV) which belongs to the genus Arterivirus of the family Arteriviridae , is the most economically significant disease effecting commercially bred pigs world-wide [ 1 ]. (ijbs.com)
- PRRSV is a positive-stranded RNA virus belonging to the genus Arterivirus of the family Arteriviridae within the order Nidovirale [ 11 , 12 ]. (ijbs.com)
- It is caused by virus classified as a member of the genus Arterivirus. (studyiq.com)
Simian1
- Simian hemorrhagic fever, an arterivirus that is already endemic in wild African primates and mostly impacts macaque monkeys, may have the potential to become the next monkeypox or even the next HIV in the future, researchers say. (ctvnews.ca)
Genome3
- We used next-generation sequencing to identify a novel arterivirus with a genome coding sequence of only 43% similarity to existing GenBank arterivirus sequences. (cdc.gov)
- The arterivirus genome is composed of a single, 12-16 kb, polyadenylated, RNA strand that contains 2 major genomic regions. (cdc.gov)
- We describe the disease history, histopathology, and the near complete genome sequence of a novel arterivirus, hedgehog arterivirus 1 (HhAV-1). (cdc.gov)
Arteriviruses1
- The arterivirus study group has now organized the viral species into 11 different categories (genera) that should facilitate nomenclature of any newly discovered arteriviruses. (usda.gov)
Hedgehog1
- Genomic organization of hedgehog arterivirus-1. (cdc.gov)
Coronavirus2
- Zn(2+) inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. (asai.ie)
- Van den Blocke was born in Königsberg (today Kaliningrad), Ducal 4 Nov 2010 inhibits coronavirus and arterivirus RNA polymerase activity in vitro and zinc ionophores block the replication of these viruses in cell culture. (web.app)
Infection1
- Just because we haven't diagnosed a human arterivirus infection yet doesn't mean that no human has been exposed. (koamnewsnow.com)
Entry2
- The presented data about the minor glycoproteins of the EAV may facilitate studies on the Arterivirus entry. (fu-berlin.de)
- A new U.S. NIH sponsored study has shockingly found that a primate hemorrhagic fever-causing arterivirus from Africa has acquired the necessary mutations to cross over into the human species using the CD162 receptors for cellular entry. (thailandmedical.news)
Infections4
- The type species of the genus ARTERIVIRUS and the etiologic agent of an important equine respiratory disease causing abortion, pneumonia, or other infections. (lookformedical.com)
- Infections caused by viruses of the genus ARTERIVIRUS. (lookformedical.com)
- The concept includes ARTERIVIRUS INFECTIONS and CORONAVIRIDAE INFECTIONS . (bvsalud.org)
- Simian hemorrhagic fever virus is an arterivirus that naturally infects species of African nonhuman primates causing acute or persistent asymptomatic infections. (omicsdi.org)
Porcine3
- In addition to SHFV, the arterivirus family includes Porcine reproductive and respiratory syndrome virus (PRRSV), which causes disease in pigs, and Equine arteritis virus (EAV), which causes disease in horses. (infectioncontroltoday.com)
- The porcine reproductive and respiratory syndrome virus (PRRSV) is an arterivirus of the Arteriviridae family. (semanticscholar.org)
- Conzelmann K.K., Visser N., Van Woensel P., Thiel H.J., Molecular characterization of porcine reproductive and respiratory syndrome virus, a member of the arterivirus group, Virology 193 (1993) 329-339. (vetres.org)
Simian1
- Previously, only nine genome sequences, known as transcription regulatory sequences (TRSs), were reported for the arterivirus Simian hemorrhagic fever virus (SHFV), which infects monkeys. (infectioncontroltoday.com)
Viruses2
- The mechanism of arterivirus cell entry has not been fully elucidated, although these viruses are thought to enter cells through receptor-mediated endocytosis. (nih.gov)
- Again, especially in the number of these side effects in general practice and arterivirus rna viruses. (pdccreative.com)
Reproductive1
- A species of ARTERIVIRUS causing reproductive and respiratory disease in pigs. (lookformedical.com)
Species1
- A species ARTERIVIRUS, occurring in a number of transplantable mouse tumors. (lookformedical.com)
Virus13
- El virus del PRRS tiene un tropismo extremadamente restringido para algunas subpoblaciones de macrófagos que pueden encontrarse en pulmón, placenta y órganos linfoides. (prrscontrol.com)
- Recientes estudios señalan que el virus del PRRS también es capaz de infectar y replicarse en otros subtipos celulares, tales como las células dendríticas derivadas de médula ósea o de monocitos. (prrscontrol.com)
- Hasta la fecha, el CD163 se considera como el principal receptor que media en la internalización del virus y el desenvolvimiento. (prrscontrol.com)
- Inicialmente, la replicación del virus ocurre en los macrófagos permisivos locales, predominantemente en el pulmón. (prrscontrol.com)
- El virus puede detectarse en sangre (viremia) en horas (6-12h. (prrscontrol.com)
- Tras la fase de viremia, el virus se puede encontrar confinado durante largo tiempo en los órganos linfoides secundarios, manteniendo un nivel de replicación bajo. (prrscontrol.com)
- En algunos casos, el antígeno ha podido ser detectado hasta 251 días tras la infección y el virus infectivo hasta 157 tras la infección. (prrscontrol.com)
- En los pulmones, las células que mantienen principalmente la replicación del virus son los macrófagos alveolares y los macrófagos intravasculares . (prrscontrol.com)
- El virus compromete sus funciones y provoca la infiltración de células inflamatorias y la consecuente neumonía intersticial, la cual, junto con el engrosamiento de los linfonodos, son las lesiones más comunes en la infección por el virus del PRRS. (prrscontrol.com)
- En este sentido, es importante subrayar que ninguna de estas lesiones es exclusiva de este virus. (prrscontrol.com)
- El virus del PRRS puede participar como agente primario en el complejo respiratorio porcino (CRP). (prrscontrol.com)
- En los casos clínicos del CRP, es el virus que se aísla más frecuentemente. (prrscontrol.com)
- Además, el virus cruza la barrera placentaria de forma mucho más eficiente en el último tercio de la gestación (después del día 85, aproximadamente), a través de macrófagos infectados. (prrscontrol.com)