Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.
Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.
The transference of a heart from one human or animal to another.
Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.
Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.
Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.
The main trunk of the systemic arteries.
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.
The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.
The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.
Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.
The nonstriated involuntary muscle tissue of blood vessels.
The veins and arteries of the HEART.
A non-atherosclerotic, inflammatory thrombotic disease that commonly involves small and medium-sized arteries or veins in the extremities. It is characterized by occlusive THROMBOSIS and FIBROSIS in the vascular wall leading to digital and limb ISCHEMIA and ulcerations. Thromboangiitis obliterans is highly associated with tobacco smoking.
Either of the two principal arteries on both sides of the neck that supply blood to the head and neck; each divides into two branches, the internal carotid artery and the external carotid artery.
The immune responses of a host to a graft. A specific response is GRAFT REJECTION.
The vessels carrying blood away from the heart.
Pathological processes involving any part of the AORTA.
Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
A cyclic undecapeptide from an extract of soil fungi. It is a powerful immunosupressant with a specific action on T-lymphocytes. It is used for the prophylaxis of graft rejection in organ and tissue transplantation. (From Martindale, The Extra Pharmacopoeia, 30th ed).
The inferior and superior venae cavae.
The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.
Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.
A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.
The region of the lower limb between the FOOT and the LEG.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
The new and thickened layer of scar tissue that forms on a PROSTHESIS, or as a result of vessel injury especially following ANGIOPLASTY or stent placement.
Inflammation of any one of the blood vessels, including the ARTERIES; VEINS; and rest of the vasculature system in the body.
An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
A cytosolic carbonic anhydrase isoenzyme primarily expressed in skeletal muscle (MUSCLES, SKELETAL). EC 4.2.1.-
A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.
A mixture of solid hydrocarbons obtained from petroleum. It has a wide range of uses including as a stiffening agent in ointments, as a lubricant, and as a topical anti-inflammatory. It is also commonly used as an embedding material in histology.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.
Any of the tubular vessels conveying the blood (arteries, arterioles, capillaries, venules, and veins).
The rhythmical expansion and contraction of an ARTERY produced by waves of pressure caused by the ejection of BLOOD from the left ventricle of the HEART as it contracts.
Loss of vascular ELASTICITY due to factors such as AGING; and ARTERIOSCLEROSIS. Increased arterial stiffness is one of the RISK FACTORS for many CARDIOVASCULAR DISEASES.
Antibodies from an individual that react with ISOANTIGENS of another individual of the same species.
The main artery of the thigh, a continuation of the external iliac artery.
Non-striated, elongated, spindle-shaped cells found lining the digestive tract, uterus, and blood vessels. They are derived from specialized myoblasts (MYOBLASTS, SMOOTH MUSCLE).
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Pathological conditions involving the CAROTID ARTERIES, including the common, internal, and external carotid arteries. ATHEROSCLEROSIS and TRAUMA are relatively frequent causes of carotid artery pathology.
Death and putrefaction of tissue usually due to a loss of blood supply.
A thiol-containing amino acid formed by a demethylation of METHIONINE.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The study, based on direct observation, use of statistical records, interviews, or experimental methods, of actual practices or the actual impact of practices or policies.
Postmortem examination of the body.
Cholesterol present in food, especially in animal products.
Pathological processes involving any of the BLOOD VESSELS in the cardiac or peripheral circulation. They include diseases of ARTERIES; VEINS; and rest of the vasculature system in the body.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The middle layer of blood vessel walls, composed principally of thin, cylindrical, smooth muscle cells and elastic tissue. It accounts for the bulk of the wall of most arteries. The smooth muscle cells are arranged in circular layers around the vessel, and the thickness of the coat varies with the size of the vessel.
A diet that contributes to the development and acceleration of ATHEROGENESIS.
The vessels carrying blood away from the capillary beds.
A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
Pathologic deposition of calcium salts in tissues.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
A condition with abnormally high levels of CHOLESTEROL in the blood. It is defined as a cholesterol value exceeding the 95th percentile for the population.
Elements of limited time intervals, contributing to particular results or situations.
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
Conditions with excess LIPIDS in the blood.
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The inferior part of the lower extremity between the KNEE and the ANKLE.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Radiography of blood vessels after injection of a contrast medium.
The continuation of the axillary artery; it branches into the radial and ulnar arteries.
The arterial blood vessels supplying the CEREBRUM.
Transference of an organ between individuals of the same species or between individuals of different species.
A layer of epithelium that lines the heart, blood vessels (ENDOTHELIUM, VASCULAR), lymph vessels (ENDOTHELIUM, LYMPHATIC), and the serous cavities of the body.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
An adhesion-promoting leukocyte surface membrane heterodimer. The alpha subunit consists of the CD11b ANTIGEN and the beta subunit the CD18 ANTIGEN. The antigen, which is an integrin, functions both as a receptor for complement 3 and in cell-cell and cell-substrate adhesive interactions.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.
Therapy for the insufficient cleansing of the BLOOD by the kidneys based on dialysis and including hemodialysis, PERITONEAL DIALYSIS, and HEMODIAFILTRATION.
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)
A strain of Rattus norvegicus used as a normotensive control for the spontaneous hypertensive rats (SHR).
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
The end-stage of CHRONIC RENAL INSUFFICIENCY. It is characterized by the severe irreversible kidney damage (as measured by the level of PROTEINURIA) and the reduction in GLOMERULAR FILTRATION RATE to less than 15 ml per min (Kidney Foundation: Kidney Disease Outcome Quality Initiative, 2002). These patients generally require HEMODIALYSIS or KIDNEY TRANSPLANTATION.
A group of intracellular-signaling serine threonine kinases that bind to RHO GTP-BINDING PROTEINS. They were originally found to mediate the effects of rhoA GTP-BINDING PROTEIN on the formation of STRESS FIBERS and FOCAL ADHESIONS. Rho-associated kinases have specificity for a variety of substrates including MYOSIN-LIGHT-CHAIN PHOSPHATASE and LIM KINASES.
Obstruction of flow in biological or prosthetic vascular grafts.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
Infection with CYTOMEGALOVIRUS, characterized by enlarged cells bearing intranuclear inclusions. Infection may be in almost any organ, but the salivary glands are the most common site in children, as are the lungs in adults.
Drugs used to cause dilation of the blood vessels.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
The transference of a kidney from one human or animal to another.
A family of non-enveloped viruses infecting mammals (MASTADENOVIRUS) and birds (AVIADENOVIRUS) or both (ATADENOVIRUS). Infections may be asymptomatic or result in a variety of diseases.
Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.
Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
White blood cells. These include granular leukocytes (BASOPHILS; EOSINOPHILS; and NEUTROPHILS) as well as non-granular leukocytes (LYMPHOCYTES and MONOCYTES).
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A non-selective inhibitor of nitric oxide synthase. It has been used experimentally to induce hypertension.
Substances that reduce or suppress INFLAMMATION.
A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.
Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.
A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.
A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.
The circulation of the BLOOD through the MICROVASCULAR NETWORK.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Mature LYMPHOCYTES and MONOCYTES transported by the blood to the body's extravascular space. They are morphologically distinguishable from mature granulocytic leukocytes by their large, non-lobed nuclei and lack of coarse, heavily stained cytoplasmic granules.
The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.

Donor MHC and adhesion molecules in transplant arteriosclerosis. (1/6134)

Transplant-associated arteriosclerosis remains an obstacle to long-term graft survival. To determine the contribution to transplant arteriosclerosis of MHC and adhesion molecules from cells of the donor vasculature, we allografted carotid artery loops from six mutant mouse strains into immunocompetent CBA/CaJ recipients. The donor mice were deficient in either MHC I molecules or MHC II molecules, both MHC I and MHC II molecules, the adhesion molecule P-selectin, intercellular adhesion molecule (ICAM)-1, or both P-selectin and ICAM-1. Donor arteries in which ICAM-1, MHC II, or both MHC I and MHC II were absent showed reductions in neointima formation of 52%, 33%, and 38%, respectively, due primarily to a reduction in smooth muscle cell (SMC) accumulation. In P-selectin-deficient donor arteries, neointima formation did not differ from that in controls. In donor arteries lacking both P-selectin and ICAM-1, the size of the neointima was similar to that in those lacking ICAM-1 alone. In contrast, neointima formation increased by 52% in MHC I-deficient donor arteries. The number of CD4-positive T cells increased by 2.8-fold in MHC I-deficient arteries, and that of alpha-actin-positive SMCs by twofold. These observations indicate that ICAM-1 and MHC II molecules expressed in the donor vessel wall may promote transplant-associated arteriosclerosis. MHC I molecules expressed in the donor may have a protective effect.  (+info)

Blocking very late antigen-4 integrin decreases leukocyte entry and fatty streak formation in mice fed an atherogenic diet. (2/6134)

Atherosclerotic lesion development is characterized by the recruitment of leukocytes, principally monocytes, to the vessel wall. Considerable interest has been focused on the adhesion molecule(s) involved in leukocyte/endothelial interactions. The goal of the present study was to determine the role of the very late antigen-4 (VLA-4) integrin/ligand interaction in fatty streak development using murine models. Because alpha4 null mice are not viable, a peptidomimetic was used to block VLA-4-mediated leukocyte binding. The ability of a synthetic peptidomimetic of connecting segment-1 (CS-1 peptide) to block the recruitment of leukocytes and the accumulation of lipid in the aortic sinus of either wild-type mice (strain C57BL/6J) or mice with a low-density lipoprotein null mutation (LDLR-/-) maintained on an atherogenic diet was assessed. The active (Ac) CS-1 peptide or scrambled (Sc) CS-1 peptide was delivered subcutaneously into mice using a mini osmotic pump. Mice were exposed to the peptide for 24 to 36 hours before the onset of the atherogenic diet. In C57BL/6J mice, leukocyte entry into the aortic sinus, as assessed by en face preparations, was inhibited by the active peptide (Ac=28+/-4, Sc=54+/-6 monocytes/valve; P=0.004). Additionally, frozen sections stained with Oil Red O were analyzed to assess lipid accumulation in the aortic sinus. C57BL/6J mice that received the (Ac) compound demonstrated significantly reduced lesion areas as compared with mice that received the (Sc) peptide (Ac=4887+/-4438 microm2, Sc=15 009 +/-5619 microm2; P<0.0001). In a separate study, LDLR-/- mice were implanted with pumps containing either the (Ac) or (Sc) peptide before initiation of the atherogenic diet. Because LDLR-/- mice fed a chow diet displayed small lesions at 14 weeks, the effects of the peptide seen in these animals represented a change in early lipid accumulation rather than initiation. By using whole-mount preparations, the (Ac) but not the (Sc) peptide significantly reduced the area of lipid accumulation in the aortic sinus, resulting in an approximate 66% decrease. Plasma analysis from all studies revealed concentrations of peptide to be present at levels previously determined by in vitro analysis to block adhesion. (Ac) CS-1 peptide, which blocks VLA-4 on the leukocyte surface, is effective in reducing leukocyte recruitment and lipid accumulation in the aortic sinus. The present study provides in vivo evidence that the VLA-4 integrin plays an important role in the initiation of the atherosclerotic lesion and lipid accumulation, and it suggests a potential therapeutic strategy for this disease.  (+info)

Prevalence of peripheral arterial disease and associated risk factors in American Indians: the Strong Heart Study. (3/6134)

Studies of peripheral arterial disease (PAD) in minority populations provide researchers with an opportunity to evaluate PAD risk factors and disease severity under different types of conditions. Examination 1 of the Strong Heart Study (1989-1992) provided data on the prevalence of PAD and its risk factors in a sample of American Indians. Participants (N = 4,549) represented 13 tribes located in three geographically diverse centers in the Dakotas, Oklahoma, and Arizona. Participants in this epidemiologic study were aged 45-74 years; 60% were women. Using the single criterion of an ankle brachial index less than 0.9 to define PAD, the prevalence of PAD was approximately 5.3% across centers, with women having slightly higher rates than men. Factors significantly associated with PAD in univariate analyses for both men and women included age, systolic blood pressure, hemoglobin A1c level, albuminuria, fibrinogen level, fasting glucose level, prevalence of diabetes mellitus, and duration of diabetes. Multiple logistic regression analyses were used to predict PAD for women and men combined. Age, systolic blood pressure, current cigarette smoking, pack-years of smoking, albuminuria (micro- and macro-), low density lipoprotein cholesterol level, and fibrinogen level were significantly positively associated with PAD. Current alcohol consumption was significantly negatively associated with PAD. In American Indians, the association of albuminuria with PAD may equal or exceed the association of cigarette smoking with PAD.  (+info)

Chlamydia pneumoniae and atherosclerosis. (4/6134)

OBJECTIVE: To review the literature for evidence that chronic infection with Chlamydia pneumoniae is associated with atherosclerosis and acute coronary syndromes. DATA SOURCES: MEDLINE and Institute of Science and Information bibliographic databases were searched at the end of September 1998. Indexing terms used were chlamydi*, heart, coronary, and atherosclerosis. Serological and pathological studies published as papers in any language since 1988 or abstracts since 1997 were selected. DATA EXTRACTION: It was assumed that chronic C pneumoniae infection is characterised by the presence of both specific IgG and IgA, and serological studies were examined for associations that fulfilled these criteria. Pathological studies were also reviewed for evidence that the presence of C pneumoniae in diseased vessels is associated with the severity and extent of atherosclerosis. DATA SYNTHESIS: The majority of serological studies have shown an association between C pneumoniae and atherosclerosis. However, the number of cases in studies that have reported a positive association when using strict criteria for chronic infection is similar to the number of cases in studies which found no association. Nevertheless, the organism is widely found in atherosclerotic vessels, although it may not be at all diseased sites and is not confined to the most severe lesions. Rabbit models and preliminary antibiotic trials suggest that the organism might exacerbate atherosclerosis. CONCLUSION: More evidence is required before C pneumoniae can be accepted as playing a role in atherosclerosis. Although use of antibiotics in routine practice is not justified, large scale trials in progress will help to elucidate the role of C pneumoniae.  (+info)

Expression and cellular localization of the CC chemokines PARC and ELC in human atherosclerotic plaques. (5/6134)

Local immune responses are thought to play an important role in the development of atherosclerosis. Histological studies have shown that human atherosclerotic lesions contain T lymphocytes throughout all stages of development, many of which are in an activated state. A number of novel CC chemokines have been described recently, which are potent chemoattractants for lymphocytes: PARC (pulmonary and activation-regulated chemokine), ELC (EBI1-ligand chemokine), LARC (liver and activation-regulated chemokine), and SLC (secondary lymphoid-tissue chemokine). Using reverse transcriptase-polymerase chain reaction and in situ hybridization, we have found gene expression for PARC and ELC but not for LARC or SLC in human atherosclerotic plaques. Immunohistochemical staining of serial plaque sections with specific cell markers revealed highly different expression patterns of PARC and ELC. PARC mRNA was restricted to CD68+ macrophages (n = 14 of 18), whereas ELC mRNA was widely expressed by macrophages and intimal smooth muscle cells (SMC) in nearly all of the lesions examined (n = 12 of 14). ELC mRNA was also found to be expressed in the medial SMC wall of highly calcified plaques (n = 4). Very low levels of ELC mRNA expression could also be detected in normal mammary arteries but no mRNA expression for PARC was detected in these vessels (n = 4). In vitro, ELC mRNA was found to be up-regulated in aortic SMC stimulated with tumor necrosis factor-a and interferon-gamma but not in SMC stimulated with serum. Both PARC and ELC mRNA were expressed by monocyte-derived macrophages but not monocytes. The expression patterns of PARC and ELC mRNA in human atherosclerotic lesions suggest a potential role for these two recently described CC chemokines in attracting T lymphocytes into atherosclerotic lesions.  (+info)

Suppression of atherosclerotic development in Watanabe heritable hyperlipidemic rabbits treated with an oral antiallergic drug, tranilast. (6/6134)

BACKGROUND: Inflammatory and immunological responses of vascular cells have been shown to play a significant role in the progression of atheromatous formation. Tranilast [N-(3,4-dimethoxycinnamoyl) anthranillic acid] inhibits release of cytokines and chemical mediators from various cells, including macrophages, leading to suppression of inflammatory and immunological responses. This study tested whether tranilast may suppress atheromatous formation in Watanabe heritable hyperlipidemic (WHHL) rabbits. METHODS AND RESULTS: WHHL rabbits (2 months old) were given either 300 mg x kg-1 x d-1 of tranilast (Tranilast, n=12) or vehicle (Control, n=13) PO for 6 months. Tranilast treatment was found to suppress the aortic area covered with plaque. Immunohistochemical analysis showed that there was no difference in the percentage of the RAM11-positive macrophage area and the frequency of CD5-positive cells (T cells) in intimal plaques between Tranilast and Control. Major histocompatibility complex (MHC) class II expression in macrophages and interleukin-2 (IL-2) receptor expression in T cells, as markers of the immunological activation in these cells, was suppressed in atheromatous plaque by tranilast treatment. Flow cytometry analysis of isolated human and rabbit peripheral blood mononuclear cells showed that an increase in expression both of MHC class II antigen on monocytes by incubation with interferon-gamma and of IL-2 receptor on T cells by IL-2 was suppressed by the combined incubation with tranilast. CONCLUSIONS: The results indicate that tranilast suppresses atherosclerotic development partly through direct inhibition of immunological activation of monocytes/macrophages and T cells in the atheromatous plaque.  (+info)

Expression of stromelysin-3 in atherosclerotic lesions: regulation via CD40-CD40 ligand signaling in vitro and in vivo. (7/6134)

Stromelysin-3 is an unusual matrix metalloproteinase, being released in the active rather than zymogen form and having a distinct substrate specificity, targeting serine proteinase inhibitors (serpins), which regulate cellular functions involved in atherosclerosis. We report here that human atherosclerotic plaques (n = 7) express stromelysin-3 in situ, whereas fatty streaks (n = 5) and normal arterial specimens (n = 5) contain little or no stromelysin-3. Stromelysin-3 mRNA and protein colocalized with endothelial cells, smooth muscle cells, and macrophages within the lesion. In vitro, usual inducers of matrix metalloproteinases such as interleukin-1, interferon-gamma, or tumor necrosis factor alpha did not augment stromelysin-3 in vascular wall cells. However, T cell-derived as well as recombinant CD40 ligand (CD40L, CD154), an inflammatory mediator recently localized in atheroma, induced de novo synthesis of stromelysin-3. In addition, stromelysin-3 mRNA and protein colocalized with CD40L and CD40 within atheroma. In accordance with the in situ and in vitro data obtained with human material, interruption of the CD40-CD40L signaling pathway in low density lipoprotein receptor-deficient hyperlipidemic mice substantially decreased expression of the enzyme within atherosclerotic plaques. These observations establish the expression of the unusual matrix metalloproteinase stromelysin-3 in human atherosclerotic lesions and implicate CD40-CD40L signaling in its regulation, thus providing a possible new pathway that triggers complications within atherosclerotic lesions.  (+info)

High-resolution intravascular magnetic resonance imaging: monitoring of plaque formation in heritable hyperlipidemic rabbits. (8/6134)

BACKGROUND: The individual makeup of atherosclerotic plaque has been identified as a dominant prognostic factor. With the use of an intravascular magnetic resonance (MR) catheter coil, we evaluated the effectiveness of high-resolution MR in the study of the development of atherosclerotic lesions in heritable hyperlipidemic rabbits. METHODS AND RESULTS: Sixteen hyperlipidemic rabbits were investigated at the ages of 6, 12, 24, and 36 months. The aorta was studied with digital subtraction angiography and high-resolution MR with the use of a surface coil and an intravascular coil that consisted of a single-loop copper wire integrated in a 5F balloon catheter. Images were correlated with histological sections regarding wall thickness, plaque area, and plaque components. Digital subtraction angiography revealed no abnormalities in the 6- and 12-month-old rabbits and only mild stenoses in the 24- and 36-month-old rabbits. High-resolution imaging with surface coils resulted in an in-plane resolution of 234x468 microm. Delineation of the vessel wall was not possible in younger rabbits and correlated only poorly with microscopic measurements in the 36-month-old rabbits. Intravascular images achieved an in-plane resolution of 117x156 microm. Increasing thickness of the aortic wall and plaque area was observed with increasing age. In the 24- and 36-month-old animals, calcification could be differentiated from fibrous and fatty tissue on the basis of the T2-fast spin echo images, as confirmed by histological correlation. CONCLUSIONS: Atherosclerotic evolution of hyperlipidemic rabbits can be monitored with high-resolution intravascular MR imaging. Image quality is sufficient to determine wall thickness and plaque area and to differentiate plaque components.  (+info)

Journal of Atherosclerosis Research and Reviews is a peer-reviewed online journal that publishes high-quality manuscripts that are recent advances in understanding the processes responsible and associated with research on atherosclerosis, its risk factors and clinical manifestations.
BACKGROUND:. Signaling events after activation of toll-like receptors (TLRs) are important mechanisms promoting inflammation in the atherosclerotic plaque. INF regulatory factor 5 (IRF5) is one of the mediators of downstream effects of TLRs. Several single nucleotide polymorphisms (SNPs) in the IRF5 gene have been found to be associated with systemic lupus erythematosus.. METHODS AND RESULTS:. We examined IRF5 mRNA expression in carotid atherosclerotic tissue (n=99) and the case-control association between SNPs in the IRF5 gene with myocardial infarction (MI) (n=376+387) and unstable coronary artery disease (CAD) (n=3101+445). Among unstable CAD patients, association of IRF5 SNPs with recurrent coronary events (n=401) was also investigated. The IRF5 mRNA expression was increased in atherosclerotic tissue compared with control tissue (P,0.001). Significant associations with IRF5 expression was observed for 6 of 10 SNPs in the study. However, the IRF5 SNPs examined were neither associated with the ...
Adhesion molecules play a crucial role in transplant rejection in regulating the interaction of inflammatory cells with cells in the vascular wall. In an aortic transplantation model, we have previously analysed the early adhesion process (7.5 min to 24 h) and the impact of cold ischaemia time (1-24 h) upon transplant arteriosclerosis during the first 2 months after transplantation in the rat. The aim of this investigation was to study adhesion molecules in accelerated transplant arteriosclerosis in a rat model by analysing the immunohistochemical expression of CD11b and ICAM-1 up to 2 months and followed by a semiquantitative evaluation and multivariant analysis. Antigen expression of CD11b and ICAM-1 adhesion molecules was stronger in the aortic allografts than in the ischaemia-induced syngeneic aortic grafts in the whole vessel wall. Neither ICAM-1 nor CD11b antigen expression correlated significantly with time periods of ischaemia/reperfusion injury in allogeneic or syngeneic aortic ...
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Serum A FABP was reported to JNJ-7706621 443797-96-4 become reduced with statin treatment, but improved with the therapy of thiazolidinedione. Regardless of va
НИИ атеросклероза: научные исследования, публикации сотрудников института (abstracts, full-text.), дискуссионный клуб, посвященный вопросам механизмов атерогенеза.
TY - JOUR. T1 - Changes in IP3 Receptor Expression and Function in Aortic Smooth Muscle of Atherosclerotic Mice. AU - Ewart, Marie Ann. AU - Ugusman, Azizah. AU - Vishwanath, Anisha. AU - Almabrouk, Tarek A M. AU - Alganga, Husam. AU - Katwan, Omar J.. AU - Hubanova, Pavlina. AU - Currie, Susan. AU - Kennedy, Simon. PY - 2017/4/1. Y1 - 2017/4/1. N2 - Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that relaxation to peroxynitrite was maintained during the development of atherosclerosis due to changes in the expression of calcium-regulatory proteins. In this study we investigated: (1) the mechanism of peroxynitrite-induced relaxation in the mouse aorta, (2) the effect of atherosclerosis on relaxation to peroxynitrite and other vasodilators, and (3) the effect of atherosclerosis on the expression and function of the ...
Although guidelines currently suggest that diabetes is a CHD risk equivalent, many with diabetes in the MESA cohort did not reach the expected 2% annual CHD rate. Even when MetS or diabetes was present, unless CAC or CIMT was significant, CHD or CVD event rates were as low as in those without these conditions, questioning whether diabetes is a universal CHD risk equivalent. In fact, the observed annual rate for CHD events in those with diabetes was ,1% in those without CAC (38% of those with diabetes). Our data suggest that CAC screening strongly stratifies CHD and CVD event risk in individuals with MetS and diabetes, showing that they have a wide range of risk based on the extent of CAC present, supporting the conclusion of a large meta-analysis (6) showing that many individuals with diabetes are not at a customary CHD risk equivalent status and suggesting that treatment should be based on individualized CHD risk assessment.. Our study is the first large population-based study comparing the ...
Arteriosclerotic Plaque development is actually a typical procedure and is contrary to the belief of several science procedures and programs. Arteriosclerotic factually known as hardening of artery. As humans age, the walls of the blood vessel also grow a bit harder and stiffer, with less flexibility. One of the very common problems of arteriosclerosis is […]. ...
The integrity of the endothelium can be damaged in various ways, making the formation of atherosclerotic lesions possible. The source of cells involved in endothelial repair and smooth-muscle accumulation in lesions has been debated, but data suggest progenitor cells as a likely origin. Their role in the pathogenesis of atherosclerosis is discussed here. During the pathogenesis of arteriosclerosis, endothelial cells on the arterial wall damaged by various means were initially thought to be replaced by replication of neighboring cells. Smooth-muscle cells (SMCs) were also thought to migrate from the media into the intima, where they constituted arteriosclerotic lesions. This concept has been challenged, however, by the discovery that progenitor cells in the circulation and adventitia contribute to endothelial repair and SMC accumulation. Studies have demonstrated that atherosclerosis is a pathophysiologic process initiated by endothelial death in specific areas, such as bifurcation regions, and with
Looking for Atheromatous plaque? Find out information about Atheromatous plaque. A lipid deposit in the inner wall of an artery; characteristic of atherosclerosis Explanation of Atheromatous plaque
#DiseaseDetail#Coronary Artery Bypass - Overview Arteriosclerosis occurs when the blood vessels that carry oxygen and nutrients from your heart to the rest of your body (arteries) become thick and stiff - sometimes restricting blood flow to your organs and tissues. Healthy arteries are flexible and elastic, but over time, the walls in your arteries can harden, a condition commonly called hardening of the arteries. Atherosclerosis is a specific type of arteriosclerosis, but the terms are sometimes used interchangeably. Atherosclerosis refers to the buildup of fats, cholesterol and other substances in and on your artery walls (plaque), which can restrict blood flow. The plaque can burst, triggering a blood clot. Although atherosclerosis is often considered a heart problem, it can affect arteries anywhere in your body. Atherosclerosis may be preventable and is treatable. Symptoms Atherosclerosis develops gradually. Mild atherosclerosis usually doesnt have any symptoms. You usually wont have
In no less than quite a few circumstances, atherosclerotic lesions are monoclonal, suggesting that Nowells legislation / all-natural collection operates inside their pathogenesis. This isnt surprising, Specially considering that (1) we now are aware that oxidized-LDL is mitogenic for macrophages, and (two) the smooth muscle mass with the aorta by itself is created of huge teams of clonal cells (Am. J. Path. 152: 913, 1998). Having said that, the outdated declare that each plaque occurs from an individual cell has now been amply refuted. Substantially operate now signifies that progression through the fatty streak to your fibrous plaque is at least partially the results of incorporation and Group of thrombi (* the Rokitansky theory, is smart). Most fibrous plaques are full of content that immunostains as fibrin (nevertheless This is often absent from standard artery or fatty streaks ...
The functions of resident CD11c+ myeloid cells in healthy mouse aorta and in the initiation of atherosclerosis. In atherosclerotic lesions, myeloid cells (macrophages and dendritic cells) and oxidatively-modified lipids accumulate underneath the endothelium in the arterial intima (the inner layer of the artery facing the lumen). Previously, we showed that in the normal mouse aorta CD11c+ myeloid cells reside preferentially in regions predisposed to atherosclerosis. Upon feeding a high cholesterol diet to atherosclerosis-susceptible low-density lipoprotein receptor deficient (LDLR-/-) mice, intimal CD11c+ cells accumulate intracellular lipid even prior to the recruitment of blood monocytes. Collectively, our studies showed that the low-grade monocyte recruitment in lesion-prone regions of the aorta accounts for resident intimal CD11c+ myeloid cell accumulation in the steady state, and that these cells promote atherosclerotic lesion formation and monocyte recruitment to the aortic intima in the ...
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Tony Kim is an assistant professor of mechanical engineering at Georgia Tech, and discusses how microchips and nanomaterials are used in his research.
The immune system serves to protect the host from a diverse array of pathogens that evolve rapidly in an effort to breach immune security checkpoints. These defense mechanisms operate continuously to keep exogenous pathogens from propagating their own species, although this heightened security has unintended and detrimental consequences to the host.1 Although this maladaptive immune response is classically associated with noninfectious diseases, such as arthritis, gout, and lupus, uncontrolled inflammation is emerging as a causative factor in the development of cardiovascular disease as well.. Atherosclerosis is a widely known condition in which the immune system causes harm to the host. Classically defined as a disease that is initiated by alterations in cholesterol metabolism and the subendothelial retention of low-density lipoproteins (LDL),2 we now know that activation of both innate and adaptive immunity participate in atherogenesis.3 Advanced atherosclerotic plaques are characterized by ...
OBJECTIVE: Oxidized lipids and proteins, as well as decreased antioxidant levels, have been detected in human atherosclerotic lesions, with oxidation catalyzed by iron and copper postulated to contribute to lesion development. Zinc has been postulated to displace iron from critical sites and thereby protect against damage. In this study, metal ion and protein oxidation levels were quantified in human carotid and abdominal artery specimens containing early-to-advanced lesions, to determine whether zinc concentrations correlate inversely with iron levels and protein oxidation.. METHODS AND RESULTS: Metal ions were quantified by EPR and inductively coupled plasma mass spectroscopy. Native and oxidized protein side-chains were quantified by high-performance liquid chromatography. Elevated levels of zinc ( approximately 6-fold) were detected in advanced lesions compared to healthy tissue or early lesions. Zinc did not correlate negatively with iron or copper levels suggesting that zinc does not ...
Despite substantial gains in the prevention and treatment of acute myocardial infarction, many atherothrombotic events occur among individuals without readily apparent risk factors. Several lines of basic research indicate that inflammation and perhaps chronic infection may play important roles in the initiation and progression of atherosclerosis. For example, pathological studies demonstrate that atherosclerotic lesions are heavily infiltrated with cellular components associated with inflammation, influx of neutrophils into the walls of the epicardial vessels has been demonstrated in response to acute ischemia, and sites of acute plaque rupture are preferentially associated with inflammatory components.1 2 3 4 5 6 Further, proinflammatory cytokines as well as cellular adhesion molecules involved in the attachment of monocytes to the endothelial wall appear to be critical in early atherogenesis.7 8 With regard to chronic infection, evidence of prior exposure to Chlamydia pneumoniae, ... - Science - [ASAP] Pterostilbene Attenuates Experimental Atherosclerosis through Restoring Catalase-Mediated Redox Balance in Vascular Smooth Muscle Cells (Journal of Agricultural and Food Chemistry)
Smoking Causes Atherosclerosis on Stop Smoking Tips | Smoking is one of the major causes of atherosclerosis which is a disease where plaque builds up inside…
Results None of the treatments altered peripheral blood monocyte counts or plasma cholesterol. mU1 reduced aortic root intimal lesion area by 20% (P , 0.05) and aortic root circumference by 12% (P = 0.01). All 3 doses of XL784 significantly decreased oil-red O-positive lesion area (36 - 42%; P , 0.05 for all). All XL784 doses also reduced aortic root intimal lesion area (22 - 29%; P , 0.05 for low dose only). The highest XL784 dose also reduced total macrophage-positive lesion area (33%; P , 0.05). All XL784 doses yielded trends towards decreased aortic root circumference (5 - 10%). Neither mU1 nor XL784 significantly altered percent aortic surface lesion coverage. ...
Newly recognized as a clinical diagnosis, Lp(a) elevation is a major contributor to cardiovascular disease risk should be considered for patients with advanced premature atherosclerosis on imaging or a family history of premature cardiovascular disease, particularly when there are few traditional risk factors ...
3. Cardiovascular molecular imaging using targeted contrast agents Atherosclerosis and its resulting cardiovascular complications are the leading cause of morbidity and mortality in the western world. The progression, erosion and rupture of atherosclerotic plaques are regarded as the precipitating event for thrombus formation in myocardial infarction and stroke. Early non-invasive testing in symptomatic or asymptomatic patients can help to guide specific therapies or interventions, and may therefore help to reduce morbidity and mortality. Recent progress in magnetic resonance imaging (MRI) has provided the technical prerequisites to allow imaging of atherosclerotic plaques. There is currently considerable interest in developing contrast-ligand probes to enable imaging of specific molecules, cells and processes that are important to atherosclerosis. We have previously used functionalized microparticles of iron oxide (MPIO) to specifically target activated platelets. Therefore, we used a unique ...
The following Expert Roundtable Discussion was held on November 13, 2011. Dr. Daniel J. Rader from the University of Pennsylvania moderated the topic The Role of HDL-C in the Management of Atherosclerosis with Drs. H. Bryan Brewer from MedStar Research Institute and Atherosclerosis Research, Jean-Claude Tardif from the Research Center of the Montreal Heart Institute, and
Clogged arteries caused by atherosclerotic plaque are deadly. Learn how you can safely clean your clogged arteries and get your blood flowing freely.
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CT scanning of the heart is becoming increasingly common in Norway. CT coronary angiography is a non-invasive method used to diagnose and chart arteriosclerotic disease. The method also lends itself ...
Full (ordinary) membership. Potential members are nominated by two members of the Society and present a brief CV to demonstrate at least five years active contribution to the field of atherosclerosis and/or related research.. Intending ORDINARY new members should email a brief curriculum vitae which demonstrates at least five years active contribution to the field of atherosclerosis research to the Secretary of the Society, together with the names of two existing members of the Society who have agreed to nominate and second their application.. Traditionally, the ADG and now the BAS have worked hard to maintain an even balance of clinical and basic scientists in the membership of the Society. Currently there are over 100 subscribing members, with over 30 retired or corresponding members, several of whom are also regular and active participants at the meetings.. ORDINARY members automatically become SENIOR members on the 1st January following their 65th birthday and do not pay an annual ...
Atherosclerosis is a type of arteriosclerosis. Atherosclerosis (AS) is characterized by yellow atheromatous plaques up to 1.5 cm in diameter that line at least part of the lumen of the vessel. These plaques are found to contain a superficial fibrous cap which is composed of smooth muscle cells, leukocytes, and dense collagen. Under this cap are more smooth muscle cells, macrophages, and T-cells. There may also be a central area of necrosis, which is very prominent in this slide. This central area is characterized by dead cells, lipid, cholesterol clefts (seen occupying the majority of the right half of this slide), foamy macrophages, and plasma proteins. The atheroma is often preceded by a fatty streak. Contrast this atheroma with a complicated one. Fifty percent of all deaths in the United States are attributable to atherosclerosis. We suggest you use Normal, rather than Full when the viewer requests a choice. ...
Fibrolipid plaque. Light micrograph of a section through a fibrolipid plaque in an artery affected by a complicated atheromatous lesion. Atheroma is the deposition of fatty material (lipids) on the inner walls of an artery. This deposit is known as a plaque. Once fibrous tissue develops in an atheromatous lesion it is called a fibrolipid plague. As the plaque enlarges, the blood supply to the vessel lining may be cut off leading to cell death (necrosis) and causing the surface to become ulcerated. This rough surface causes coagulation of the blood and the formation of a thrombus at the site of the ulcerated atheroma. - Stock Image C003/0193
(2007) J.-J. et al. Ageing Research Reviews. Vascular calcification is an age-dependent, common finding in human coronary arteries and begins as early as the second decade of life, just after fatty streak formation. Previous studies have show...
CiteSeerX - Scientific articles matching the query: Toward early diagnosis of arteriosclerotic diseases: collaborative detection of carotid artery calcifications by computer and dentists on dental panoramic radiographs
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice. Mol Cell. 1998 Aug; 2(2):275-81 ...
Title: Macrophage-Derived Foam Cells in Atherosclerosis: Lessons from Murine Models and Implications for Therapy. VOLUME: 8 ISSUE: 12. Author(s):Nancy R. Webb and Kathryn J. Moore. Affiliation:Lipid Metabolism Unit, Massachusetts General Hospital, 55 Fruit St, GRJ1328, Boston, MA 02114,USA.. Keywords:Macrophage foam cell, modified lipoprotein, scavenger receptor, oxidation, secretory phospholipase A2. Abstract: Macrophage-derived foam cells play integral roles in all stages of atherosclerosis. These lipid-laden immune cells are present from the earliest discernable fatty-streak lesions to advanced plaques, and are key regulators of the pathologic behavior of plaques. This review summarizes the current understanding of the molecular mechanisms that regulate macrophage cholesterol uptake, foam cell formation, and lipid-driven pro-inflammatory responses that promote atherosclerosis. Specific emphasis will be placed on recent findings from mouse models of atherosclerosis regarding the pathways of ...
TY - JOUR. T1 - Gene therapy for transplant arteriosclerosis. AU - Rekhter, M. D.. AU - Shah, N.. AU - Simari, R. D.. AU - Work, C.. AU - Kim, J. S.. AU - Nabel, G. J.. AU - Nabel, E. G.. AU - Gordon, D.. PY - 1997/12/1. Y1 - 1997/12/1. N2 - Transplant arteriosclerosis is a thickening of the intima that develops in arteries of transplanted organs. Smooth muscle cell (SMC) replication plays a central role in its pathogenesis. One strategy to selectively eliminate dividing cells is to express a herpesvirus thymidine kinase (tk) gene which phosphorylates the nucleoside analog, ganciclovir, into a toxic form which leads to cell killing. To evaluate a feasibility of transgene expression in arterial grafts, we performed ex vivo adenovirus (ADV)-mediated transfer of human placental alkaline phosphatase (hpAP) gene into aortas of donor rabbits, and then transplanted them into carotid artery of recipient rabbits. 2 days post-transplant luminal endothelial cells, adventitial cells, and medial SMCs ...
Cerebral arteriosclerosis is the result of thickening and hardening of the walls of the arteries in the brain. Symptoms of cerebral arteriosclerosis include headache, facial pain, and impaired vision.. Cerebral arteriosclerosis can cause serious health problems. If the walls of an artery are too thick, or a blood clot becomes caught in the narrow passage, blood flow to the brain can become blocked and cause an ischemic stroke. When the thickening and hardening is uneven, arterial walls can develop bulges (called aneurysms). If a bulge ruptures, bleeding in the brain can cause a hemorrhagic stroke. Both types of stroke can be fatal.. Cerebral arteriosclerosis is also related to a condition known as vascular dementia, in which small, symptom-free strokes cause cumulative damage and death to neurons (nerve cells) in the brain. Personality changes in the elderly, such as apathy, weeping, transient befuddlement, or irritability, might indicate that cerebral arteriosclerosis is present in the brain. ...
This study showed that selective neuronal damage manifested as a decrease in the BZRs in the non-infarcted cerebral cortex is associated with poor performance on the WCST in the non-disabled patients with unilateral atherosclerotic ICA or MCA disease and no cortical infarction. The BZR index of the ACA territory in the hemisphere affected by arterial disease was significantly higher in WCST-abnormal (low categories achieved for their age) patients than in WCST-normal patients, whereas the BZR index of the MCA territory was significantly different between the two groups when patients with left arterial disease were separately analysed.. This study included ICA and MCA diseases, which may have different impacts on CBF in the ACA territory. Twelve of the 17 studied patients with MCA disease had occlusion of the MCA, in which blood flowing through the ACA is redistributed via the leptomeningeal vessels to compensate for the reduced flow in the MCA, resulting in reduced flow in the ACA territory.30 ...
Atherosclerosis is recognized clinically as an arterial disease prominently involving the intima of medium- or large-sized arteries, including the aortic, carotid, coronary and cerebral arteries. Atherosclerotic lesions or plaques contain complex tissue matrix, including collagen, elastin, proteoglycans and extracellular and intracellular lipids with foamy macrophages and smooth muscle cells. In addition, inflammatory cellular components (e.g., T lymphocytes, macrophages, some basophils) also exist in the lesions. Disruption of atherosclerotic plaques appears to be the major cause of heart attacks and strokes. Although the risk of plaque rupture usually cannot be predicted, many postmortem examinations have revealed that this risk depends mainly on plaque composition (1,2). Most ruptured atherosclerotic plaques are characterized structurally by formation of a large, soft, lipid-rich, necrotic core covered by a thin fibrous cap densely infiltrated by macrophages. Inflammation is also a major ...
This work is the first to establish reproducibility of IVW for plaque identification with and without contrast. Reproducibility using contrast is important as most IVW applications rely on lesion enhancement.
Atherosclerosis Diagnosis. Atherosclerosis, also known as arteriosclerotic vascular disease, is a medical condition in which arteries begin to narrow because of an excessive amount of plaque surrounding the artery wall. This accumulation can interrupt the bodys usual blood flow, leading to dangerous possibilities in an individuals cardiovascular system. Though atherosclerosis can affect a variety of arteries, the bigger high-pressure arteries are most often influenced by this vascular condition.. Due to sometimes similar definitions, atherosclerosis and arteriosclerosis are often used interchangeably. There is a subtle difference between the two terms. Arteriosclerosis refers to the artery walls becoming hardened while atherosclerosis is defined as the artery becoming narrow due to an accumulation of plaque. Those who have atherosclerosis also have arteriosclerosis, but those with arteriosclerosis do not always have atherosclerosis.. Possible Signs of Atherosclerosis. Initial signs of ...
Arteriosclerosis is characterized by the thickening, hardening and loss of elasticity of the artery wall. Cardiovascular risk factor, atherosclerosis is a form of arteriosclerosis. What is arteriosclerosis? Arteriosclerosis is a form of sclerosis that occurs at the level of the arteries. In other words, this means that it is characterized by hardening, thickening and loss […]. ...
TY - JOUR. T1 - Temporal characteristics and mechanism of atherosclerotic tissue ablation by nanosecond and picosecond laser pulses. AU - Oraevsky, A. A.. AU - Esenaliev, R. O.. AU - Letokhov, V. S.. PY - 1992/1/1. Y1 - 1992/1/1. KW - Ablation product luminescence. KW - Aorta. KW - Laser ablation. KW - Time-resolved spectroscopy. UR - UR - M3 - Article. AN - SCOPUS:0026577875. VL - 5. SP - 75. EP - 93. JO - Lasers in the Life Sciences. JF - Lasers in the Life Sciences. SN - 0886-0467. IS - 1-2. ER - ...
Hypercholesterolemia was induced in rabbits by feeding Purina Chow supplemented with cholesterol (5 g/kg body weight/day). The serum cholesterol levels of these rabbits increased progressively and after 3 to 5 months were 4 to 9-fold greater than those of the control animals. Decrease in total hemolytic complement was not apparent during the feeding regimen. Morphologic examination of aortae of these hypercholesterolemic rabbits showed typical atherosclerotic intimal plaques. Immunofluorescent microscopy with fluorescein (F)-labeled anti-rabbit C3 showed deposition of C3 in the intimal and inner medial layers as early as 3 months on high cholesterol diet. C3 deposits were also observed in the renal glomeruli and in the walls of coronary arteries. However, fluorescent studies failed to demonstrate the presence of IgG, IgM, and C4 at these sites. Tissues from control animals fed normal diets were negative for immunoglobulins, C3, and C4. These results suggest that the complement system may be ...
Fasting hyperinsulinemia is associated with an increased risk of atherosclerotic complications of heart attack and stroke. This has resulted in the concept that insulin may promote atherosclerosis in spite of the absence of any evidence that insulin is atherogenic either in the human or in experimental models. Recent evidence shows that insulin exerts vasodilatory, anti-platelet and anti-inflammatory effects at the cellular level in vitro and in the human in vivo. Since atherosclerosis is a chronic inflammatory process of the arterial wall, insulin may be potentially anti-atherosclerotic in the long term. More recent data on experimental atherosclerosis in the mouse shows that (1) insulin administration reduces the number and the size of atherosclerotic lesions in apo E null mice and (2) in IRS-2 null mice, the interruption in insulin signal transduction results in enhanced atherogenicity. Finally, the use of a low dose of insulin infusion in patients with acute myocardial infarction has been ...
In the present study, we performed aorta transplantation to determine whether the arterial wall was a source of the difference between B6 and C3H mice in atherosclerosis susceptibility. One major finding was that aortic grafts from atherosclerosis-susceptible B6.apoE−/− mice developed significantly larger atherosclerotic lesions than those from atherosclerosis-resistant C3H.apoE−/− mice in identical F1 mice. Previously, we observed that OxLDL induces marked expression of proinflammatory genes such as MCP-1, M-CSF, and VCAM-1 in endothelial cells and vascular smooth muscle cells from B6 mice, whereas cells from C3H mice show small or no induction of these genes.5,6 In recombinant inbred strains derived from B6 and C3H strains, we found that endothelial responses to OxLDL with respect to the induction of proinflammatory genes cosegregate with the size of atherosclerotic lesions.3 Because MCP-1, M-CSF and VCAM-1 are associated with monocyte recruitment to the arterial wall and ...
The stiffening of the arteries does not take place all of a sudden. It develops over a period of time. High Blood Pressure, High Cholesterol, Obesity, chronic Kidney Disease and Diabetes tend to cause Arteriosclerosis. Irritants like nicotine and similar drugs and allergic reactions also facilitate the clogging of arteries. Besides, increasing age and a family history of heart disease can be held responsible for developing blockage in the arteries, especially the coronary arteries. Excessive consumption of alcohol and smoking can also cause Arteriosclerosis.. Symptoms of Arteriosclerosis. The symptoms of the disease are generally not dominant until the arteries become so clogged that they fail to supply sufficient amount of blood to the essential organs. The nature of symptoms depends on the location of the clogged arteries. Blockage of coronary arteries tends to result in chest pain or the symptoms of heart attack. Blockage in the carotid artery in the neck may lead to sudden weakness, ...
The natural variation among inbred strains of mice was used to elucidate the genetic factors underlying the responsiveness to high-fat and high-cholesterol diets. The nine strains examined are the progenitors of recombinant inbred strain sets: C57BL/6J, C57L/J, SWR/J, SJL/J, SM/J, A/J, AKR/J, C3H/HeJ, and DBA/2J. Plasma lipids, liver lipids, the prevalence of cholesterol gallstones, and the size of aortic fatty streak lesions were examined after 18 wk of consumption of the diet containing 15% fat and 1% cholesterol. The variation in aortic lesions found among inbred strains provided the basis for several additional studies that demonstrated the existence of eight genes affecting atherosclerosis. These genes, named Ath1 to Ath8, are briefly described. The genetic analysis of variation in gallstone formation demonstrated that more than one gene affects this phenotype.
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Arteriosclerosis Arteriosclerosis Symptoms Arteriosclerosis refers to the thickening of the walls of the arteries. It has become a common ailment in modem times, accounting for much of the disability and high death rate, more so among older people. Arte
Arteriosclerosis Global Clinical Trials Review, H1, 2017, Summary, GlobalDatas clinical trial report, Arteriosclerosis Global Clinical Trials Review, H1, 2017 provides an overview of Arteriosclerosis clinical trials scenario. This..
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The SPARC study is the only large-scale, population-based TEE study performed to date. Study participants were sampled from the adult population residing in a well-defined geographic area, are relatively free of selection bias, and are representative of the general population.. The following study limitations should be noted. First, this was a cross-sectional study, one lacking prospective follow-up data. However, data relating aortic plaque morphology, C pneumoniaeserology, and inflammatory markers to future cardiovascular and cerebrovascular events will be available during long-term follow up of the study cohort.. Second, we examined the association between C pneumoniaeIgG antibody titers and aortic atherosclerosis, assuming that the presence of IgG titers beyond a certain threshold (i.e., titers ≥1:16) is indicative of chronic C pneumoniaeinfection (7). Moreover, we examined the association between various levels of antibody titers and aortic atherosclerosis (4,7)and excluded one subject ...
Arteriosclerosis is the hardening, loss of elasticity and thickening of the walls of the arteries, leading to the gradual restriction of the flow of blood to the tissues and organs, and this can cause serious health risks through atherosclerosis, which is a type of arteriosclerosis which takes place through the buildup of cholesterol, fatty plaques, and some other substances on and in the artery walls. This is the forum for discussing anything related to this health condition
Arteriosclerosis is an actual hardening, thickening, or loss of walls of the blood vessels. Atherosclerosis is an actual type of arteriosclerosis. Fatty substances, cholesterol, cellular waste, calcium & fibrin build up in the inner lining of an artery. These substances actually make up plaque.
Semantic Scholar extracted view of [Effect of pancreatic lipase on the development of experimental atherosclerosis]. by I. P. Bondarenko
A plaque tack can be used for holding plaque against blood vessel walls such as in treating atherosclerotic occlusive disease. The plaque tack can be formed as a thin, annular band for holding loose plaque under a spring or other expansion force against a blood vessel wall. Focal elevating elements and/or other features, such as anchors, can be used to exert a holding force on a plaque position while minimizing the amount of material surface area in contact with the plaque or blood vessel wall and reducing the potential of friction with the endoluminal surface. This approach offers clinicians the ability to perform a minimally invasive post-angioplasty treatment and produce a stent-like result without using a stent.
With the help of this arteriosclerosis model with cross section of artery doctors can explain changes in the blood vessels due to arteriosclerosis.
The Arteriosclerosis, Thrombosis, and Vascular Biology document template can be used to prepare manuscripts according to the citation style and authoring guidelines of Arteriosclerosis, Thrombosis, and Vascular Biology
TY - JOUR. T1 - The role of rivaroxaban for patients with atherosclerotic vascular disease in the modern era. AU - Vogt, Joshua C.. AU - Manning, Patrick G.. AU - Sheikh, Omar. AU - Aronow, Herbert D.. AU - Chilton, Robert J.. AU - Cigarroa, Joaquin E.. PY - 2021/5/1. Y1 - 2021/5/1. KW - atherosclerosis. KW - coronary artery disease. KW - drugs/pharmacotherapy. KW - peripheral artery disease. UR - UR - U2 - 10.1002/ccd.29089. DO - 10.1002/ccd.29089. M3 - Article. C2 - 32638540. AN - SCOPUS:85087644660. VL - 97. SP - 1221. EP - 1229. JO - Catheterization and Cardiovascular Interventions. JF - Catheterization and Cardiovascular Interventions. SN - 1522-1946. IS - 6. ER - ...
Clínica e Investigación en Arteriosclerosis is the official journal of the Spanish Society of Arteriosclerosis, the Latinoamerican...
TERAJIMA Shigeru , 鈴木 研欽 , 恩田 久孝 , 仲広 志 , 吉原 英児 , 岩橋 和彦 , 栃原 敏彦 With a view to establishing criteria for prophylactic evaluation of carotid atherosclerosis on the basis of age-related characteristics of its trails, 475 healthy Japanese aged 19 to 78 years were exa … Japanese Journal of Medical Ultrasound Technology 27(4), 218-225, 2002 J-STAGE ...
In the present study, we first demonstrated increased levels of circulating oxLDL in subjects with IGT compared with NGT. Oxidative modification of lipids and proteins is a common part of inflammatory diseases including diabetes. While increased oxidation products have been found in frank diabetes (7,15), oxidative damage of lipoproteins in early stages of diabetes, particularly in IGT, has not been elucidated yet. Recently, circulating oxLDL have been shown to be a useful parameter for identifying CAD (2,7,8) and also to be a marker for differentiating the degree of severity of acute coronary syndromes (3). OxLDL are suggested to play a key role in atherogenesis, and diabetes is associated with accelerated atherosclerosis and atherosclerotic complications including CAD (4,5). The examined subjects were recruited from the RIAD study that started in 1996 as a prospective study including 40- to 70-year-old subjects at a high risk for diabetes (6). Previously, in a subgroup of the RIAD study ...
Arteriosclerosis is a disease of the arteries. The arteries transport blood that has high oxygen content from the heart to the other organs. Today scientists assume that the artery walls are aggravated chemically and small excrescences, so-called atheromatous plaque, are formed. This plaque will constrict the arteries more and more until it becomes impossible to supply the organs with enough oxygen. High LDL cholesterol levels can be responsible for the chemical aggravation, for example. In the worst case scenario the consequence is a cardiac infarction or a stroke. Arteriosclerosis in very small arteries is often a result of a long-standing diabetes. Overweight and high blood pressure also contribute to the development of arteriosclerosis. The development of atheromatous plaque in the arteries is, however, reversible. It was discovered in studies with patients that endurance sports can lead to regression of the mutations in the arteries.. ...
Atherosclerosis, the pathological process underlying myocardial infarction, stroke and other occlusive vascular disease, is the major cause of death in the Western world. The development of techniques to accurately and reproducibly detect and measure the early changes of atherosclerosis and/or to identify subjects at highest cardiovascular risk may aid in the development of prevention strategies and facilitate a decrease in morbidity and mortality from atherosclerosis. Increasing understanding of the pathophysiology of early atherosclerosis has allowed the development of a number of potential methods for the assessment of the early stages of atherosclerosis in humans. These include techniques for assessing early structural changes in the coronary arteries with electron-beam computed tomography and magnetic resonance imaging. External vascular ultrasound has also been used to image other circulations as a surrogate marker for coronary atherosclerosis, e.g. the measurement of carotid artery ...
Chips main research interests include substantial experimental models of atherosclerosis, dyslipidemia and thrombosis as well as basic research elucidating the fundamental mechanisms of cholesterol absorption and metabolism. He was one of the investigators that developed ezetimibe and discovered its molecular target, the intestinal sterol transporter NPC1L1. Chip won the 2006 PhRMA Discoverers Award, the highest scientific honor in the pharmaceutical industry, for the discovery of Zetia® and the combination therapy Vytorin®. He also played a key role in the development of the thrombin receptor antagonist Zontivity®. In 2015, Chip was honored with the Akira Endo Award from the National Lipid Association for his work in atherosclerosis research ...
Chronic hemodialysis (HD) patients are at a significantly higher risk of atherosclerotic complications when compared to normal population. In this study, baseline serum concentrations of CRP and PAPP-A were significantly higher in HD patients than in healthy controls. This is in accordance with our previous results and suggests chronic inflammation and increased cardiovascular risk in HD patients.. ...
New research in mice suggests that a compound responsible for the odor of rotting flesh can shrink the fibrous plaques that build up in the walls of arteries in atherosclerosis. Share on Pinterest Atherosclerosis is the accumulation of plaque on the inside of blood vessel walls. The researchers discovered that this chemical, which is called ...
ATVB is the forum for publication of research on the biology, prevention, and impact of vascular disease related to arteriosclerosis and thrombosis from a variety of disciplines including biochemistry, biophysics, cell and molecular biology, clinical investigation, epidemiology, genetics, lipoproteins, nutrition, metabolism, and pathology.
ATVB is the forum for publication of research on the biology, prevention, and impact of vascular disease related to arteriosclerosis and thrombosis from a variety of disciplines including biochemistry, biophysics, cell and molecular biology, clinical investigation, epidemiology, genetics, lipoproteins, nutrition, metabolism, and pathology.
[toc]Sometimes the arteries become thick and hard due to the deposition of too much plaque around the walls of the artery. Such a condition is known as
Cerebral arteriosclerosis is the result of thickening and hardening of the walls of the arteries in the brain. Symptoms of cerebral arteriosclerosi...
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Wagner DD, Burger PC (December 2003). "Platelets in inflammation and thrombosis". Arteriosclerosis, Thrombosis, and Vascular ...
A double-blind comparative study". Arteriosclerosis and Thrombosis. 11 (4): 816-26. doi:10.1161/01.ATV.11.4.816. PMID 2065035. ... Arteriosclerosis, Thrombosis, and Vascular Biology. 39 (2): e38-e81. doi:10.1161/ATV.0000000000000073. PMID 30580575.. ...
Arteriosclerosis and intestinal poisons. [a contemporary review of Metchnikoff's work] JAMA 1910, 55:2311-12. ...
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Arteriosclerosis, Thrombosis, and Vascular Biology. 27 (6): 1238-47. doi:10.1161/ATVBAHA.107.139402. PMID 17379841.. ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 19 (2): 187-195. doi:10.1161/01.atv.19.2.187. PMID 9974397.. ...
Bruemmer, D. (2012). "Targeting Angiogenesis as Treatment for Obesity". Arteriosclerosis, Thrombosis, and Vascular Biology. 32 ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 36: 1090-100. doi:10.1161/ATVBAHA.115.306964. PMC 4882253. PMID 27127201.. ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (8): 1908-1915. doi:10.1161/ATVBAHA.111.225268. PMC 3141106. Retrieved ...
Faraci FM, Didion SP (August 2004). "Vascular protection: superoxide dismutase isoforms in the vessel wall". Arteriosclerosis, ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 15 (5): 678-82. doi:10.1161/01.ATV.15.5.678. PMID 7749881.. ... Arteriosclerosis, Thrombosis, and Vascular Biology. 17 (8): 1527-31. doi:10.1161/01.ATV.17.8.1527. PMID 9301631.. ...
Arteriosclerosis, Thrombosis, and Vascular Biology. 23 (8): 1430-6. doi:10.1161/01.ATV.0000077207.49221.06. PMID 12750117.. ...
October 2009). "Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus". Arteriosclerosis, Thrombosis ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (5): 986-1000. doi:10.1161/ATVBAHA.110.207449. PMC 3081099. PMID ...
Arteriosclerosis, thrombosis, and vascular biology. 25 (9): 1972-1978. doi:10.1161/01.ATV.0000175751.30616.13. ISSN 1079-5642. ...
Arteriosclerosis, Thrombosis, and Vascular Biology. 24 (1): 41-53. doi:10.1161/01.ATV.0000099880.09014.7D. PMID 14551154. De ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 25 (12): 2451-62. doi:10.1161/01.ATV.0000186208.06964.91. PMID 16166564.. ...
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"Arteriosclerosis, Thrombosis, and Vascular Biology. 31 (11): 2749-59. doi:10.1161/ATVBAHA.111.235176. PMC 3357483. PMID ...
Mackman N (June 2004). "Role of tissue factor in hemostasis, thrombosis, and vascular development". Arteriosclerosis, ... Arteriosclerosis, Thrombosis, and Vascular Biology. 25 (8): 1545-50. doi:10.1161/ PMID 15905465.. ...
Arteriosclerosis, Thrombosis, and Vascular Biology. 36 (7): 1425-1433. doi:10.1161/ATVBAHA.116.307695. ISSN 1524-4636. PMID ...
May 2006). "Obesity and cardiovascular disease: pathophysiology, evaluation, and effect of weight loss". Arteriosclerosis, ...
Arteriosclerosis, Thrombosis, and Vascular Biology. 25 (3): 482-6. doi:10.1161/ PMID 15569818.. ...
Arteriosclerosis, thrombosis, and vascular biology. 19 (3): 680-6. doi:10.1161/01.atv.19.3.680. PMID 10073973. Yoo, H; Kim, S. ... Arteriosclerosis, Thrombosis, and Vascular Biology. 29 (6): 915-20. doi:10.1161/ATVBAHA.109.185793. PMID 19286633. Yokomizo, T ...
Reiss, A. B.; Cronstein, B. N. (8 June 2012). "Regulation of Foam Cells by Adenosine". Arteriosclerosis, Thrombosis, and ... Barletta, K. E.; Ley, K.; Mehrad, B. (8 June 2012). "Regulation of Neutrophil Function by Adenosine". Arteriosclerosis, ... Arteriosclerosis, Thrombosis, and Vascular Biology. 32 (4): 845-850. doi:10.1161/atvbaha.111.226803. PMID 22423035. Lu, D.; ...
"Professor George Joseph Popjak, MD, DSc, FRS: May 5, 1914 - December 30, 1998". Arteriosclerosis, Thrombosis, and Vascular ...
"Arteriosclerosis, Thrombosis, and Vascular Biology. 32 (12): 2836-8. doi:10.1161/ATVBAHA.112.300471. PMC 3574634. PMID 23065827 ...
Tellides G, Pober JS (2007). "Interferon-gamma axis in graft arteriosclerosis". Circ. Res. 100 (5): 622-32. doi:10.1161/01.RES. ...
Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Cardiovascular and Stroke Nursing; Council on ...
Hyperplastic: Hyperplastic arteriosclerosis refers to the type of arteriosclerosis that affects large and medium-sized arteries ... Arteriosclerosis is the thickening, hardening and loss of elasticity of the walls of arteries.[3] This process gradually ... The lesions of arteriosclerosis begin as the intima (innermost layer of blood vessel wall) of the arterial wall start to fill ... Diagnosis of an individual suspected of having arteriosclerosis can be based on a physical exam, blood test, EKG and the ...
Arteriosclerosis Monckebergs arteriosclerosis Skin lesion James, William D.; Berger, Timothy G.; et al. (2006). Andrews ... Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal aorta and the small- and ...
... or arteriosclerosis, happens when plaque collects and causes the arteries to narrow and harden, affecting blood flow. Learn ... Other terms for the condition include arteriosclerosis and hardening of the arteries. ...
Arteriosclerosis of peripheral extremities (native arteries) with ulceration of the ankle and gangrene. Is the correct way to ... Arteriosclerosis of peripheral extremities (native arteries) with ulceration of the ankle and gangrene.. Is the correct way to ...
... the predominant investigative emphasis among research workers in arteriosclerosis has been on plasma and arterial lipids. ... Lipoprotein arteriosclerosis artery atherosclerosis fat heart myocardial infarction pathogenesis plasma research tissue ... Because of their experience in the field of arteriosclerosis and their interest in stimulating new directions for research on ... 1.Department of Comparative Medicine, Arteriosclerosis Research Center, The Bowman Gray School of MedicineWake Forest ...
... Commonly called hardening of the arteries, arteriosclerosis includes a variety of conditions that cause artery ...
... is a type of arteriosclerosis. Learn about the symptoms and the personalized treatment options at UPMC. ... Atherosclerosis (Arteriosclerosis). Atherosclerosis - commonly known as hardening of the arteries - is an accumulation of ... Atherosclerosis, also referred to as arteriosclerosis, causes a hardening of the arteries due to plaque build-up. ...
The Artery and the Process of Arteriosclerosis. Pathogenesis The first half of the Proceedings of an Interdisciplinary ... The aim of the Conference was to achieve a synthesis of present knowledge concerning arterioscle- rosis. Therefore, workers ... The remainder of the proceedings, dealing with the epide- miologic, clinical and preventive aspects of arteriosclerosis, will ...
Senile arteriosclerosis definition at, a free online dictionary with pronunciation, synonyms and translation. ... Words nearby senile arteriosclerosis. senhor, senhora, senhorita, senile, senile amyloidosis, senile arteriosclerosis, senile ...
Make research projects and school reports about arteriosclerosis easy with credible articles from our FREE, online encyclopedia ... Arteriosclerosis can begin in early childhood.. The primary risk factors for arteriosclerosis include hypertension (high blood ... Arteriosclerosis. The term arteriosclerosis is used to describe several cardiovascular diseases, including those involving the ... Two types of arteriosclerosis include Monckebergs arteriosclerosis, which usually involves restricted movement of the lower ...
Find arteriosclerosis information, treatments for arteriosclerosis and arteriosclerosis symptoms. ... MedHelps arteriosclerosis Center for Information, Symptoms, Resources, Treatments and Tools for arteriosclerosis. ... hello, my mother diagnose with pancreatic head cyst, gallstone and abdomin arteriosclerosis... ...
arteriosclerosis Commonly called hardening of the arteries, arteriosclerosis includes a variety of conditions that cause artery ...
Read more for causes, symptoms, treatment & diet for arteriosclerosis ... Arteriosclerosis is a condition that involves narrowing or hardening of the arteries. ... Symptoms of Arteriosclerosis. Arteriosclerosis usually occurs in the limbs first. Initially there may be no symptoms and the ... Suggestion for Arteriosclerosis. Stress is one of the risk factors for arteriosclerosis as it contributes to high blood ...
Petra Apfalter, Francesco Blasi, Jens Boman, Charlotte A. Gaydos, Michael Kundi, Matthias Maass, Athanasios Makristathis, Adam Meijer, Reinhard Nadrchal, Kenneth Persson, Manfred L. Rotter, C. Y. William Tong, Gerold Stanek, Alexander M. Hirschl ...
Fluoride & Arteriosclerosis. By Tara Blank, PhD , July 2012 Healthy arteries are flexible and elastic, allowing efficient ... Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. This is a slow, progressive disease that ... Several studies have found that those chronically exposed to fluoride are at higher risk of suffering from arteriosclerosis. ... "Results of this study suggest that endemic fluorosis might cause aortosclerosis [arteriosclerosis of the aorta], which greatly ...
Atherosclerosis or arteriosclerosis is hardening and narrowing of the arteries where plaque builds up inside your arteries. ... Arteriosclerosis (National Institutes of Health) * Atherosclerosis (National Institutes ...
... by 2024 - published on ... Arteriosclerosis Detector Market With Leading Players like OMRON, Chioy, Lepu Ph … The arteriosclerosis detectors based on the ... Arteriosclerosis Therapeutics - Pipeline Analysis 2018, Clinical Trials & Result … Arteriosclerosis is a type of cardiovascular ... Arteriosclerosis Therapeutics Pipeline Analysis, Results, Patent & Designation Arteriosclerosis is a type of cardiovascular ...
Peripheral Atherosclerosis (or arteriosclerosis obliterans) is a type of peri-vascular disease wherein the lower limbs are ... In Arteriosclerosis, these deposits are mainly composed of calcium whereas in Atherosclerosis, these deposits mainly comprise ...
... causes of arteriosclerosis, symptoms, treatment, homeopathy medicine, and homeopathic treatment of arteriosclerosis. ... arteriosclerosis, causes of arteriosclerosis, symptoms, treatment, homeopathy medicine, and homeopathic treatment of ... Arteriosclerosis is a condition in which fatty material such as cholesterol and fat accumulates or collects along the walls of ... Diagnosis of arteriosclerosis As far as diagnosis is concerned prior to other investigations, physical examination has to be ...
Tags: Arteriosclerosis, Blood, Blood Sugar, Cancer, Cardiology, Cardiovascular Disease, CLARITY, Diabetes, Diet, GLP-1, Hormone ... As we did not have many diabetic participants in the study, we do not yet know how GIP levels affect the arteriosclerosis ... We saw that high levels of GIP were linked to a significantly higher risk of early signs of arteriosclerosis, while high levels ... Researchers find new link between incretin hormones and arteriosclerosis. *Download PDF Copy ...
Primary Safety Endpoint-Composite Major Adverse Limb Events (MALE) + perioperative death (POD); the composite is the number of participants who do not have MALE or POD at 30 ...
... Find out about atherosclerosis, a potentially serious condition where arteries become ...
This project is supported by the Canadian Institutes of Health Research (award #111062), Alberta Innovates - Health Solutions, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Alberta, Genome British Columbia, and Genome Canada, a not-for-profit organization that is leading Canadas national genomics strategy with funding from the federal government. Maintenance, support, and commercial licensing is provided by OMx Personal Health Analytics, Inc. Designed by Educe Design & Innovation Inc. ...
Using Nanoparticles To Combat Arteriosclerosis January 7, 2016. Eurasia Review 0 Comments ... In arterial calcification (arteriosclerosis), pathological deposits form in the arteries and this leads to vascular stenosis. ... In industrialized countries, a high number of people suffer from arteriosclerosis - with fatal consequences: Deposits in the ... Damage to the endothelial cells is generally the insidious onset of arteriosclerosis. ...
Arteriosclerosis is a major health problem. Arteriosclerosis can be prevented by reducing risks. Risks are smoking, obesity, ... "Arteriosclerosis". World Book Advanced. World Book, 2016. Web. 22 Feb. 2016.. *↑ Insel P.M. and Roth W.T. 2003. Cardiovascular ... The effects of arteriosclerosis can lead to lack of regular blood flow. Low blood flow to the brain can make you dizzy, numb, ... Mönckeberg Arteriosclerosis. This is when the middle layer of the artery stiffens. This is because of calcium deposits. ...
Diseases : Arteriosclerosis, Infant Nutrition: Infant Formula, Sudden Infant Death Syndrome (SIDS). Problem Substances : Infant ... Diseases : Arteriosclerosis. Pharmacological Actions : Cell cycle arrest, Enzyme Inhibitors, Vascular smooth muscle cell (VSMC ... Diseases : Arteriosclerosis. Pharmacological Actions : Antioxidants, NF-kappaB Inhibitor, Tumor Necrosis Factor (TNF) Alpha ... Diseases : Arteriosclerosis, Diabetes Mellitus: Type 2, Dyslipidemias, Inflammation, Insulin Resistance, Obesity. Additional ...
There are many herbal remedies for arteriosclerosis that can help your heart health. Learn about herbal remedies for ... About Arteriosclerosis. Atherosclerosis is a common type of arteriosclerosis in which fatty deposits partially clog or totally ... If left untreated, arteriosclerosis can raise blood pressure and put excess strain on the heart. ... The allium family is a star when it comes to fighting arteriosclerosis. Garlic and even onions have been clinically proved to ...
Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:e51, originally published September 23, 2015 ... Arteriosclerosis, Thrombosis, and Vascular Biology. 2015;35:e51, originally published September 23, 2015 ... Your Name) thought you would like to see the Arteriosclerosis, Thrombosis, and Vascular Biology web site. ... Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology. ...
  • Arteriosclerosis is the thickening, hardening and loss of elasticity of the walls of arteries . (
  • Monckeberg's arteriosclerosis or medial calcific sclerosis is seen mostly in the elderly, commonly in arteries of the extremities. (
  • Hyperplastic: Hyperplastic arteriosclerosis refers to the type of arteriosclerosis that affects large and medium-sized arteries. (
  • Hyaline arteriosclerosis, also referred to as arterial hyalinosis and arteriolar hyalinosis, refers to lesions that are caused by the deposition of homogenous hyaline in the small arteries and arterioles. (
  • Arteriosclerosis obliterans is an occlusive arterial disease most prominently affecting the abdominal aorta and the small- and medium-sized arteries of the lower extremities, which may lead to absent dorsalis pedis, posterior tibial, and/or popliteal artery pulses. (
  • Other terms for the condition include arteriosclerosis and hardening of the arteries. (
  • Arteriosclerosis of peripheral extremities (native arteries) with ulceration of the ankle and gangrene. (
  • Commonly called hardening of the arteries, arteriosclerosis includes a variety of conditions that cause artery walls to thicken and lose elasticity. (
  • Atherosclerosis, also referred to as arteriosclerosis, causes a hardening of the arteries due to plaque build-up. (
  • Arteriosclerosis is a condition that involves narrowing or hardening of the arteries. (
  • Arteriosclerosis refers to a stiffening of the arteries, including loss of elasticity. (
  • 2010). It has been suggested that fluoride-induced aortosclerosis (arteriosclerosis of the aorta) may accelerate sclerosis and calcification of conducting arteries, which in turn may further aggravate other aspects of fluoride toxicity (Song et al. (
  • Results of this study suggest that endemic fluorosis might cause aortosclerosis [arteriosclerosis of the aorta], which greatly aggravates the course and range of sclerosis and calcification of the conducting arteries and which in turn makes fluorosis severer. (
  • Arteriosclerosis is a condition in which fatty material such as cholesterol and fat accumulates or collects along the walls of arteries produces thickness and hardening with formation of plaques that narrows and blocks the arteries. (
  • Ankle brachial test - this test is done to diagnose the arteriosclerosis in the arteries of legs and feet. (
  • In industrialized countries, a high number of people suffer from arteriosclerosis - with fatal consequences: Deposits in the arteries lead to strokes and heart attacks. (
  • In arterial calcification (arteriosclerosis), pathological deposits form in the arteries and this leads to vascular stenosis. (
  • Arteriosclerosis is a diseased condition of the arteries . (
  • Commonly called hardening of the arteries, arteriosclerosis is a group of diseases characterized by thickened and hardened artery walls. (
  • The general autopsies revealed arteriosclerosis in the small arteries of the heart, spleen, and kidneys in three cases and in addition, moderate arteriosclerosis of the coronary arteries in one. (
  • The Framingham Heart Study and many other newer prospective studies have shown that the degree of hardening of the arteries throughout the body, called "arteriosclerosis" or "atherosclerosis", determines the risk of whether or not we are developing strokes and heart attacks (Ref. 1, 5 and 6). (
  • Arteriosclerosis develops when blood vessels (arteries) that convey oxygen and nutrients from your heart to the rest of your body start to become thick and hard, restricting the blood flow to your organs and tissues. (
  • Cerebral arteriosclerosis is the result of thickening and hardening of the walls of the arteries in the brain. (
  • If you have had a heart attack, stroke or any other sign of arteriosclerosis, you may need tests to see if you need surgery to open closed arteries. (
  • Arteriosclerosis refers to the thickening of the walls of the arteries. (
  • Arteriosclerosis results in the loss of elasticity of the blood vessels and a narrowing of the smaller arteries, which interferes with the free circulation of the blood. (
  • The symptoms of arteriosclerosis vary according to the arteries involved. (
  • Arteriosclerosis of the extremities is a disease of the blood vessels characterized by narrowing and hardening of the arteries that supply the legs and feet. (
  • The symptoms of arteriosclerosis vary with arteries involved. (
  • ARTERIOSCLEROSIS is a condition of mineral build-up in the arteries. (
  • Arteriosclerosis is the result of the healing process as a result of the lining of arteries being damaged. (
  • Despite severe fulminating arteriosclerosis in the carotid arteries, the cerebral arteries and the brain tissue itself show little or no significant evidence of degenerative change. (
  • An extreme type of arteriosclerosis is atherosclerosis in which the accumulated cholesterol is attacked by the immune cells. (
  • Atherosclerosis is a common type of arteriosclerosis in which fatty deposits partially clog or totally block blood flow in large, important vessels of the body such as the aorta and the blood vessels to the heart and head. (
  • Atherosclerosis is an actual type of arteriosclerosis. (
  • Atherosclerosis is specific type of arteriosclerosis. (
  • Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology. (
  • Your Name) thought you would like to see the Arteriosclerosis, Thrombosis, and Vascular Biology web site. (
  • Arteriosclerosis, thrombosis and vascular biology : journal of the American Heart Association. (
  • I thought you might be interested in this item at Title: Arteriosclerosis, thrombosis and vascular biology : journal of the American Heart Association. (
  • Peripheral Atherosclerosis (or arteriosclerosis obliterans) is a type of peri-vascular disease wherein the lower limbs are affected. (
  • The prevalence of arteriosclerosis obliterans (ASO) of the legs was determined by a battery of noninvasive tests in 141 insulin-dependent and 289 non-insulin-dependent diabetic subjects and in 64 other subjects. (
  • The analgesic effect of racemic ketamine in patients with chronic ischemic pain due to lower extremity arteriosclerosis obliterans. (
  • Chronic ischemic pain due to lower extremity arteriosclerosis obliterans often responds poorly to analgesics, and the pain-generating mechanisms are not well understood. (
  • Eight patients with rest pain in the lower extremity due to arteriosclerosis obliterans were given sub-dissociative doses of 0.15, 0.30, or 0.45 mg/kg racemic ketamine and morphine 10 mg as a 5-min infusion on four separate days in a cross-over, double-blind, randomised protocol. (
  • The lesions of arteriosclerosis begin as the intima (innermost layer of blood vessel wall) of the arterial wall start to fill up with the deposition of cellular wastes. (
  • While many cases have been observed and recorded, the term arteriosclerosis was not used until Jean Fréderic Martin Lobstein coined it while he was analyzing the composition of calcified arterial lesions. (
  • Presently, and in the past, the predominant investigative emphasis among research workers in arteriosclerosis has been on plasma and arterial lipids. (
  • Because of their experience in the field of arteriosclerosis and their interest in stimulating new directions for research on the lesion, the Committee on Coronary Artery Lesions and Myocardial Infarctions of the Council on Arteriosclerosis, American Heart Association, planned an International Workshop on Arterial Mesenchyme and Arteriosclerosis. (
  • The twenty papers and discussions presented in this volume summarize the proceedings of the Workshop and represent a comprehensive review of the role of arterial mesenchyme in arteriosclerosis. (
  • Medications for arteriosclerosis include those which help to slow down or reverse the fat buildup in the arterial walls. (
  • Surgical treatment for arteriosclerosis may include bypass surgery, removal of the arterial lining and repair or replacement of the affected blood vessel. (
  • How is Peripheral arterial disease (Arteriosclerosis) Diagnosed? (
  • How is Peripheral arterial disease (Arteriosclerosis) Treated? (
  • Arteriosclerosis is a term for the thickening and hardening of arterial walls. (
  • We've only scratched the surface of our herbal remedies for arteriosclerosis. (
  • [3] This process gradually restricts the blood flow to one's organs and tissues and can lead to severe health risks brought on by atherosclerosis , which is a specific form of arteriosclerosis caused by the buildup of fatty plaques, cholesterol , and some other substances in and on the artery walls. (
  • It is the most common form of arteriosclerosis. (
  • Second, atherosclerosis is a form of arteriosclerosis. (
  • Among the signs/symptoms of arteriosclerosis may include sudden weakness, facial or lower limbs numbness , confusion , difficulty understanding speech and problems seeing. (
  • Cardiovascular diseases that were caused by arteriosclerosis also caused almost 812,000 deaths in 2008, more than any other cause, including cancer . (
  • Arteriosclerosis is the main reason behind cardiovascular disease such as heart attack. (
  • The National Heart and Lung Institute Task Force on Arteriosclerosis has advocated (1) creation of a national program to prevent and control arteriosclerosis and specifically recommended the establishment of national centers for prevention of arteriosclerosis, cardiovascular disease prevention clinics, lipid research clinics, and an Office of Health Education in the National Heart and Lung Institute. (
  • Arteriosclerosis, increasing future risks of cardiovascular events even in its early stages, occurs in the vessel walls where stimulation stress, known as wall shear stress (WSS), is constantly lower than 0.4 Pa (referred to as low-WSS vessels). (
  • Clínica e Investigación en Arteriosclerosis is the official journal of the Spanish Society of Arteriosclerosis, the Latinoamerican Society of Arteriosclerosis and the Iberolatinoamerican Society of Arteriosclerosis. (
  • This is the earliest stage of arteriosclerosis noted in this series. (
  • Objective: To observe the effect of angiotensin II (Ang II) on expression of gap junction channel protein connexin 43 (Cx43) in the proliferation process of vascular smooth muscle cells (VSMCs) during the early stage of arteriosclerosis. (
  • As these start to mature, they can take different forms of arteriosclerosis. (
  • Such a condition is known as arteriosclerosis. (
  • is coronary artery disease also known as arteriosclerosis and myocardial infarction? (
  • Industrial pollution - this is now a major cause of arteriosclerosis. (
  • The effects of arteriosclerosis can lead to lack of regular blood flow. (
  • The remainder of the proceedings, dealing with the epide- miologic, clinical and preventive aspects of arteriosclerosis, will be published in a second volume. (
  • The Clinical Aspects of Arteriosclerosis. (
  • The major part of this book is devoted to the cardiac aspects of arteriosclerosis, with a section on its cerebral, aortic, peripheral vascular, retinal, renal and pulmonary aspects. (
  • The prevalence of arteriosclerosis as defined by brachial-ankle pulse wave velocity values higher than the age and sex stratified references from the low risk subjects was 27.1% for men and 25.4% for women. (
  • A number of risks linked to the development of arteriosclerosis have been identified. (
  • It is the responsibility of the health care provider to help individuals modify or eliminate from their lives risk factors for the development of arteriosclerosis. (
  • Can there be any herbal or 'all natural' medicine / supplement proven to cure atherosclerosis and arteriosclerosis? (
  • arteriosclerosis (ärtĬr´ēōsklərō´sis) , general term for a condition characterized by thickening, hardening, and loss of elasticity of the walls of the blood vessels. (
  • Arteriosclerosis is an actual hardening, thickening, or loss of walls of the blood vessels. (
  • Have it 2-3 times every day a curcumin protects the walls of the blood vessels from any kind of damage and thus prevents arteriosclerosis. (
  • Arteriosclerosis is a cholesterol based disease that is caused due to thickening of diameters of blood vessels of the body. (
  • Arteriosclerosis is one of the most common diseases of the blood vessels. (
  • Arteriosclerosis is usually preceded by artherosclerosis, a kind of degeneration or softening of the inner lining of the blood vessels walls. (
  • Cerebral arteriosclerosis is a condition which occurs when the blood vessels which carry blood and nutrients get thickened and stiff. (
  • Treatments For Arteriosclerosis Blood Pressure With Effective Home Remedies Arteriosclerosis is a chronic condition of the heart which is characterized by a narrowing of the blood vessels. (
  • The current study is the first in which researchers take measurements from people - and across a large population - to investigate the link between the levels of GIP and GLP-1 in the blood and measurements of early arteriosclerosis. (
  • For early arteriosclerosis detection, we previously proposed a WSS-measurement method and detected low-WSS vessels by comparing the threshold value with the WSS calculated at a given moment when the mean flow-velocity maximized, presuming that the WSS maximized simultaneously at all measurement points. (
  • The aim of homeopathy is not only to treat arteriosclerosis but to address its underlying cause and individual susceptibility. (
  • As far as therapeutic medication is concerned, several remedies are available to treat arteriosclerosis that can be selected on the basis of cause, sensations and modalities of the complaints. (
  • Some countries are known to treat arteriosclerosis by using Hyperbaric oxygen. (
  • The influence of the somatostatin analogue angiopeptin on transplant arteriosclerosis was investigated using two aortic transplantation rat models. (
  • We conclude that angiopeptin has no clear immunosuppressive properties but may counteract ischemia-induced transplant arteriosclerosis. (
  • Diagnosis of an individual suspected of having arteriosclerosis can be based on a physical exam , blood test , EKG and the results of these tests (among other exams). (
  • Medical therapy is often prescribed to help prevent arteriosclerosis for underlying conditions, such as medications for the treatment of high cholesterol, medications to treat high blood pressure (e.g. (
  • Although the relationship between blood cholesterol levels and arteriosclerosis is not fully understood, the utilization of low-density lipids appears to be a primary indicator of the risk of arteriosclerosis. (
  • Physicians also may recommend treatments to help people control high blood pressure, quit cigarette smoking, and reduce cholesterol levels, all of which are risk factors for cerebral arteriosclerosis. (
  • A high blood pressure, increase in the cholesterol level and too much smoking leads to arteriosclerosis. (
  • Cayenne pepper reduces the cholesterol level and thus helps to get rid of arteriosclerosis. (
  • GlobalData's clinical trial report, "Arteriosclerosis Global Clinical Trials Review, H1, 2017" offers an overview of Arteriosclerosis clinical trials scenario. (
  • This industry report offers best line data relating to the clinical trials on Arteriosclerosis. (
  • The 10 younger patients showed less clinical evidence of arteriosclerosis than the older ones, and responded significantly better to treatment with levodopa. (
  • The clinical beraing of the primary mechanical genesis of arteriosclerosis. (
  • Global Info Research offers a latest published report on Arteriosclerosis Testers Market Analysis and Forecast 2019-2025 delivering key insights and providing a competitive advantage to clients through a detailed report. (
  • The worldwide market for Arteriosclerosis Testers is expected to grow at a CAGR of roughly x% over the next five years, will reach x million US$ in 2024, from x million US$ in 2019, according to a new GIR (Global Info Research) study. (
  • The following Thyroid Arteriosclerosis Coronary Artery side effect reports were submitted by healthcare professionals and consumers. (
  • This information will help you understand how side effects, such as Arteriosclerosis Coronary Artery, can occur, and what you can do about them. (
  • This Arteriosclerosis Coronary Artery side effect was reported by a consumer or non-health professional from UNITED STATES. (
  • Individuals with arteriosclerosis may complain of chronic pain in the legs. (
  • Chronic progressive leukoencephalopathy with systemic arteriosclerosis in young adults. (
  • Clinicopathological studies of four cases of chronic progressive leukoencephalopathy with systemic arteriosclerosis are reported. (
  • Indeed, arteriosclerosis is an inevitable result of Western lifestyles with their reliance on a highly refined carbohydrate diet, poor micronutrient status, increasing pollution of the environment including prescription medication, lack of sunshine and exercise, and chronic lack of sleep. (
  • Why is arteriosclerosis chronic? (
  • The significance of some of these observations made it clear that there was need for intensified research on the connective tissue components of the arteriosclerotic lesion and that arteriosclerosis research workers could benefit from a more comprehensive view of the subject. (
  • Cinnarizine is a medication derivative of piperazine, and characterized as an antihistamine and a calcium channel blocker, it is also known to promote cerebral blood flow, and so is used to treat cerebral apoplexy, post-trauma cerebral symptoms, and cerebral arteriosclerosis.However, it is more commonly prescribed for nausea and vomiting due to motion sickness or other sources such as chemotherapy, [4] vertigo, or Ménière's disease. (
  • Arteriosclerosis risk factors include hypertension , elevated levels of fats in the blood, cigarette smoking, diabetes mellitus, and obesity. (
  • Men are at a greater risk of developing arteriosclerosis. (
  • However, the estrogen levels drop after menopause and hence the risk of arteriosclerosis increases. (
  • The risk of arteriosclerosis can increase considerably based on certain lifestyle choices. (
  • Several studies have found that those chronically exposed to fluoride are at higher risk of suffering from arteriosclerosis. (
  • Family history - people who have family history of heart disease or arteriosclerosis are at increased risk. (
  • We saw that high levels of GIP were linked to a significantly higher risk of early signs of arteriosclerosis, while high levels of GLP-1 were instead linked to a lower risk. (
  • The findings in this new study indicate that there may be a link between raised GIP levels in the blood and a risk of arteriosclerosis. (
  • Avoiding cigarettes is another way to significantly reduce risk of arteriosclerosis, since smoking is widely acknowledged as a key contributor to onset of the disease. (
  • The journal is the leading Spanish written peer-review journal in the field of arteriosclerosis and its related risk factors. (
  • Oregano has been discovered to carry in it a substance- beta-caryophyllin (E-BCP) - that not only cures inflammation but can also be helped to cut the risk of osteoporosis and arteriosclerosis. (
  • Western diets result in diabetes and high blood-pressure, both of which are major risk factors for arteriosclerosis. (
  • So the bottom line is that if your parents have arteriosclerosis you are at greater risk. (
  • Arteriosclerosis has several contributing risk factors. (
  • Arteriosclerosis Monckeberg's arteriosclerosis Skin lesion James, William D. (
  • If these changes are not made, arteriosclerosis will continue, and the fatty deposits will again build up. (
  • Mönckeberg's arteriosclerosis arteriosclerosis with extensive deposits of calcium in the middle coat of the artery. (
  • Diet is also thought to be a major factor in arteriosclerosis, especially since the most common variety of this condition, called atherosclerosis, involves the deposition plaques composed of fatty materials. (
  • Atherosclerosis is actually a specific kind of arteriosclerosis and is a treatable condition. (
  • Cerebral arteriosclerosis is also related to a condition known as vascular dementia, in which small, symptom-free strokes cause cumulative damage and death to neurons (nerve cells) in the brain. (
  • Increase in proline hydroxylase activity may be a possible biochemical defect in the aortas of rabbits with arteriosclerosis induced by injury. (
  • Prevention of Arteriosclerosis in Rabbits on a Hypercholesterolemic Diet by Ileal Bypass. (
  • Oregano keeps Inflammation, Osteoporosis and Arteriosclerosis at bay! (
  • This formula eliminates the energetic field within which Arteriosclerosis occurs and returns the body to normal functioning. (
  • what is the definition or description of: coronary arteriosclerosis? (
  • Could alternative medicine offer any solutions regarding arteriosclerosis and removal of plaque from coronaries? (
  • Does alternative medicine offer any good solutions related to arteriosclerosis and removal of plaque from coronaries? (
  • The objective was to evaluate the efficacy and safety of combination of beraprost and aspirin for prevention of arteriosclerosis progress in type 2 diabetes mellitus patients. (
  • Medication, surgical intervention and lifestyle modifications are all part of arteriosclerosis treatment. (
  • Now researchers from Lund University in Sweden have noted new links between these hormones and arteriosclerosis, and believe their discovery could be significant for treatment of diabetes in the future. (
  • Dzialek E, Orzechowska-Wolczyk M, Zawadzki Z. [Cosaldon in the treatment of cerebral arteriosclerosis]. (
  • TY - JOUR T1 - [Cosaldon in the treatment of cerebral arteriosclerosis]. (
  • Treatment for cerebral arteriosclerosis can include medications or surgery. (
  • Planet Ayurveda provides best combination of effective herbal remedies such as Heart Care Pack for ayurvedic treatment of arteriosclerosis. (
  • what is the treatment for coronary arteriosclerosis? (
  • what treatment option integrates treatment for high blood pressure, arteriosclerosis, atherosclerosis, and coronary heart? (
  • ACE inhibitors ), [2] and antiplatelet medications , are often prescribed to help prevent arteriosclerosis. (
  • Arteriosclerosis can be treated through medications and lifestyle changes. (
  • Following are the complete list of our medications under Arteriosclerosis category. (