Arteriolosclerosis: Thickening of the walls of small ARTERIES or ARTERIOLES due to cell proliferation or HYALINE deposition.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Indigo Carmine: Indolesulfonic acid used as a dye in renal function testing for the detection of nitrates and chlorates, and in the testing of milk.BooksEmbryology: The study of the development of an organism during the embryonic and fetal stages of life.Plumbaginaceae: A plant family of the order Plumbaginales, subclass Caryophyllidae, class Magnoliopsida of shrubs and herbs. Some members contain ANTHOCYANINS and naphthaquinones.Mortuary Practice: Activities associated with the disposition of the dead. It excludes cultural practices such as funeral rites.Book SelectionBook Reviews as Topic: Critical analyses of books or other monographic works.Arteriosclerosis Obliterans: Common occlusive arterial disease which is caused by ATHEROSCLEROSIS. It is characterized by lesions in the innermost layer (ARTERIAL INTIMA) of arteries including the AORTA and its branches to the extremities. Risk factors include smoking, HYPERLIPIDEMIA, and HYPERTENSION.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.beta-Thalassemia: A disorder characterized by reduced synthesis of the beta chains of hemoglobin. There is retardation of hemoglobin A synthesis in the heterozygous form (thalassemia minor), which is asymptomatic, while in the homozygous form (thalassemia major, Cooley's anemia, Mediterranean anemia, erythroblastic anemia), which can result in severe complications and even death, hemoglobin A synthesis is absent.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Fatigue Syndrome, Chronic: A syndrome characterized by persistent or recurrent fatigue, diffuse musculoskeletal pain, sleep disturbances, and subjective cognitive impairment of 6 months duration or longer. Symptoms are not caused by ongoing exertion; are not relieved by rest; and result in a substantial reduction of previous levels of occupational, educational, social, or personal activities. Minor alterations of immune, neuroendocrine, and autonomic function may be associated with this syndrome. There is also considerable overlap between this condition and FIBROMYALGIA. (From Semin Neurol 1998;18(2):237-42; Ann Intern Med 1994 Dec 15;121(12): 953-9)Colestipol: Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.Pleurodynia, Epidemic: An acute, febrile, infectious disease generally occurring in epidemics. It is usually caused by coxsackieviruses B and sometimes by coxsackieviruses A; echoviruses; or other enteroviruses.Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.Attention Deficit Disorder with Hyperactivity: A behavior disorder originating in childhood in which the essential features are signs of developmentally inappropriate inattention, impulsivity, and hyperactivity. Although most individuals have symptoms of both inattention and hyperactivity-impulsivity, one or the other pattern may be predominant. The disorder is more frequent in males than females. Onset is in childhood. Symptoms often attenuate during late adolescence although a minority experience the full complement of symptoms into mid-adulthood. (From DSM-V)Amyotrophic Lateral Sclerosis: A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94)Gastroesophageal Reflux: Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.AxisTeaching Materials: Instructional materials used in teaching.Pharmacology, Clinical: The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.Competitive Behavior: The direct struggle between individuals for environmental necessities or for a common goal.Cerebral Small Vessel Diseases: Pathological processes or diseases where cerebral MICROVESSELS show abnormalities. They are often associated with aging, hypertension and risk factors for lacunar infarcts (see LACUNAR INFARCTION); LEUKOARAIOSIS; and CEREBRAL HEMORRHAGE.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Spondylolisthesis: Forward displacement of a superior vertebral body over the vertebral body below.Science: The study of natural phenomena by observation, measurement, and experimentation.Leukoencephalopathies: Any of various diseases affecting the white matter of the central nervous system.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Nerve Fibers, Myelinated: A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Dementia, Vascular: An imprecise term referring to dementia associated with CEREBROVASCULAR DISORDERS, including CEREBRAL INFARCTION (single or multiple), and conditions associated with chronic BRAIN ISCHEMIA. Diffuse, cortical, and subcortical subtypes have been described. (From Gerontol Geriatr 1998 Feb;31(1):36-44)Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Mild Cognitive Impairment: A prodromal phase of cognitive decline that may precede the emergence of ALZHEIMER DISEASE and other dementias. It may include impairment of cognition, such as impairments in language, visuospatial awareness, ATTENTION and MEMORY.Heart: The hollow, muscular organ that maintains the circulation of the blood.Coronary Vessels: The veins and arteries of the HEART.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Myocardium: The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Heart Atria: The chambers of the heart, to which the BLOOD returns from the circulation.Laser Therapy: The use of photothermal effects of LASERS to coagulate, incise, vaporize, resect, dissect, or resurface tissue.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Cardiopulmonary Bypass: Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Coronary Artery Bypass, Off-Pump: Coronary artery bypass surgery on a beating HEART without a CARDIOPULMONARY BYPASS (diverting the flow of blood from the heart and lungs through an oxygenator).Coronary Circulation: The circulation of blood through the CORONARY VESSELS of the HEART.Pulmonary Artery: The short wide vessel arising from the conus arteriosus of the right ventricle and conveying unaerated blood to the lungs.Vascular Neoplasms: Neoplasms located in the vasculature system, such as ARTERIES and VEINS. They are differentiated from neoplasms of vascular tissue (NEOPLASMS, VASCULAR TISSUE), such as ANGIOFIBROMA or HEMANGIOMA.Endothelial Cells: Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.Endothelium, Vascular: Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Pulmonary Embolism: Blocking of the PULMONARY ARTERY or one of its branches by an EMBOLUS.

CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16. (1/10)

BACKGROUND: Previous studies have demonstrated that macrophages and CD4+ T lymphocytes play pivotal roles in collateral development. Indirect evidence suggests that CD8+ T cells also play a role. Thus, after acute cerebral ischemia, CD8+ T cells infiltrate the perivascular space and secrete interleukin-16 (IL-16), a potent chemoattractant for monocytes and CD4+ T cells. We tested whether CD8+ T lymphocytes contribute to collateral vessel development and whether the lack of circulating CD8+ T cells prevents IL-16 expression, impairs CD4+ mononuclear cell recruitment, and reduces collateral vessel growth after femoral artery ligation in CD8(-/-) mice. METHODS AND RESULTS: After surgical excision of the femoral artery, laser Doppler perfusion imaging demonstrated reduced blood flow recovery in CD8(-/-) mice compared with C57/BL6 mice (ischemic/nonischemic limb at day 28, 0.66+/-0.04 versus 0.87+/-0.04, respectively; P<0.01). This resulted in greater calf muscle atrophy (mean fiber area, 785+/-68 versus 1067+/-69 microm2, respectively; P<0.01) and increased fibrotic tissue content (10.8+/-1.2% versus 7+/-1%, respectively; P<0.01). Moreover, CD8(-/-) mice displayed reduced IL-16 expression and decreased CD4+ T-cell recruitment at the site of collateral vessel development. Exogenous CD8+ T cells, infused into CD8(-/-) mice immediately after femoral artery ligation, selectively homed to the ischemic hind limb and expressed IL-16. The restoration of IL-16 expression resulted in significant CD4+ mononuclear cell infiltration of the ischemic limb, faster blood flow recovery, and reduced hindlimb muscle atrophy/fibrosis. When exogenous CD8+ T cells deficient in IL-16 (IL-16(-/-)) were infused into CD8(-/-) mice immediately after femoral artery ligation, they selectively homed to the ischemic hind limb but were unable to recruit CD4+ mononuclear cells and did not improve blood flow recovery. CONCLUSIONS: These results demonstrate that CD8+ T cells importantly contribute to the early phase of collateral development. After femoral artery ligation, CD8+ T cells infiltrate the site of collateral vessel growth and recruit CD4+ mononuclear cells through the expression of IL-16. Our study provides further evidence of the significant role of the immune system in modulating collateral development in response to peripheral ischemia.  (+info)

Association between serum adiponectin levels and arteriolosclerosis in IgA nephropathy patients. (2/10)

OBJECTIVE: Adiponectin has attracted great attention because of its anti-atherogenic properties; however, to date the relationship between serum adiponectin and arteriolosclerosis has not been reported. In our study, we aimed to examine whether or not serum adiponectin levels are associated with arteriolosclerosis in patients with IgA nephropathy which is the most common form of chronic glomerulonephritis. MATERIALS AND METHODS: We enrolled 35 patients aged 35.0+/-14.6, who underwent renal biopsy from August 2004 to February 2006 in our hospital, and were confirmed to have IgA nephropathy. We examined serum adiponectin, high-sensitive C-reactive protein, total cholesterol and triglyceride level, urinary protein excretion, body mass index (BMI), and the presence of arteriolosclerosis in the renal specimens. Since the serum adiponectin level is strongly affected by renal function, we classified the patients by creatinine clearance. RESULTS: Multiple regression analysis showed the associations of adiponectin with creatinine clearance (p<0.001), BMI (p<0.001), serum triglyceride (p=0.001) and urinary protein excretion (p=0.001). We observed a positive relation of adiponectin with urinary protein excretion and an inverse relation of adiponectin with creatinine clearance, serum triglyceride, and BMI. We could not detect any relation between the presence of arteriolosclerosis and adiponectin in the IgA nephropathy patients as a whole; however, in patients whose creatinine clearance was 90-120 ml/min/1.73 m2, the serum adiponectin level of patients with arteriolosclerosis was lower than in those without arteriolosclerosis (p=0.025). CONCLUSION: The serum level of adiponectin was related to arteriolosclerosis in IgA nephropathy patients whose renal function was almost normal. Adiponectin may prevent renal arteriolosclerosis.  (+info)

Lead, at low levels, accelerates arteriolopathy and tubulointerstitial injury in chronic kidney disease. (3/10)

Chronic lead exposure has been epidemiologically linked with hypertension and renal disease. Clinical studies suggest that low lead levels may contribute to renal progression. However, experimental studies have not examined whether low levels of lead accelerate progression in experimental chronic renal disease. Sprague-Dawley rats were administered lead (L; 150 ppm in drinking water, n = 16) for 4 wk, followed by remnant kidney (RK) surgery with continuation of lead for an additional 12 wk; control rats (n = 9) were treated similarly but did not receive lead. Lead treatment was well tolerated and resulted in modest elevations in whole blood lead levels (26.4 +/- 4.5 vs. 1 +/- 0 mug/dl, week 16, P < 0.001). Lead treatment was associated with higher systolic blood pressure (P < 0.05) and worse renal function (creatinine clearance 1.4 +/- 0.4 vs. 1.8 +/- 0.5 ml/min, RK+L vs. RK, P < 0.05), and with a tendency for greater proteinuria (6.6 +/- 6.1 vs. 3.6 +/- 1.5 mg protein/mg creatinine, RK+L vs. RK, P = 0.08). While glomerulosclerosis tended to be worse in lead-treated rats (37.6 +/- 11 vs. 28.8 +/- 2.3%, RK+L vs. RK, P = 0.06), the most striking finding was the development of worse arteriolar disease (P < 0.05), peritubular capillary loss (P < 0.05), tubulointerstitial damage, and macrophage infiltration (P < 0.05) in association with significantly increased renal expression of monocyte chemoattractant protein-1 mRNA. In conclusion, lead accelerates chronic renal disease, primarily by raising blood pressure and accelerating microvascular and tubulointerstitial injury.  (+info)

Apo B/Apo A-I ratio in central and peripheral arterial diseases. (4/10)

BACKGROUND: The apo B/apo A-I ratio represents the balance between atherogenic particles, rich in apo B, and the antiatherogenic ones, apo A-I rich. This study investigated the association between atherosclerotic diseases in different anatomical sites and apo B/apo A-I ratio. METHODS: Lipids, lipoproteins, and apolipoproteins A-I and B were assessed in 30 subjects with coronary artery disease (CAD), 26 with ischemic stroke (IS), 30 with peripheral arterial obstructive disease (PAOD), and 38 healthy subjects (controls). RESULTS: HDLc and Apo A-I were significantly lower in PAOD and CAD groups, respectively, than in other groups. Significantly higher levels of triglycerides were observed for CAD and PAOD groups than for controls. Apo B was significantly higher in IS group than in control and PAOD groups. The apo B/apo A-I ratio showed significantly higher in CAD and IS groups when compared to control and PAOD groups (p < 0.001). CONCLUSION: The apo B/apo A-I ratio was important for identifying an increased trend for coronary and cerebral atherosclerosis. In spite of the increased trend for apo B/apo A-I ratio in IS and CAD groups, the studied variables cannot be considered in an isolated way, given as those parameters were analyzed together by a binary logistic regression, no association has been demonstrated.  (+info)

Cholesterol-lowering effect of kori-tofu protein and its high-molecular-weight fraction content. (5/10)

The serum total cholesterol concentration was significantly lower in the kori-tofu feeding group than in the soy protein isolate (SPI) group, except on the 28th day of the experiment. The high-molecular-weight fraction (HMF) content of the kori-tofu protein was significantly higher than that of SPI. This difference in the HMF content may have influenced the cholesterol-lowering effect of the protein.  (+info)

Chronic kidney disease, severe arterial and arteriolar sclerosis and kidney neoplasia: on the spectrum of kidney involvement in MELAS syndrome. (6/10)

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Serum complement C3 predicts renal arteriolosclerosis in non-diabetic chronic kidney disease. (7/10)

AIM: Complement C3 (C3) is one of the major mediators of inflammation. Serum C3 has been shown to be correlated with the presence of atherosclerosis. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in patients with chronic kidney disease (CKD). METHODS: Non-diabetic CKD (stages 1-3) patients who underwent renal biopsy were enrolled in this study. Renal arteriolosclerosis was defined by the presence of hyaline changes and vessel wall thickening in the renal biopsy specimens. We examined whether the serum C3 level might be correlated with the severity of renal arteriolosclerosis in CKD patients. RESULTS: A total of 208 CKD patients (age 36.0+/-13.6 years; 94 male) who underwent renal biopsy were included. Univariate analysis showed that the serum C3 level was positively correlated with age, body mass index, blood pressure and the serum triglyceride, LDL cholesterol and CRP (p<0.001). The serum C3 level was also inversely correlated with serum HDL cholesterol (p<0.001). Multiple regression analysis identified that the serum C3 (p=0.043) as well as age (p<0.001), serum uric acid (p=0.009) and eGFR (p= 0.025) were independently associated with the severity of renal arteriolosclerosis. CONCLUSION: Our results suggest that the serum C3 level is a reliable marker of renal arteriolosclerosis. Components of metabolic syndrome were also correlated with the serum C3 level. Inflammation or metabolic syndrome may contribute to CKD through influencing the rate of progression of renal arteriolosclerosis.  (+info)

Relationship of red splenic arteriolar hyaline with rapid death: a clinicopathological study of 82 autopsy cases. (8/10)

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Synonyms for arteriolosclerosis in Free Thesaurus. Antonyms for arteriolosclerosis. 2 words related to arteriolosclerosis: induration, sclerosis. What are synonyms for arteriolosclerosis?
Play media Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of arterioles or small arteries and is most often associated with hypertension and diabetes mellitus. Types include hyaline arteriolosclerosis and hyperplastic arteriolosclerosis, both involved with vessel wall thickening and luminal narrowing that may cause downstream ischemic injury. The following two terms whilst similar, are distinct in both spelling and meaning and may easily be confused with arteriolosclerosis. Arteriosclerosis is a general term describing any hardening (and loss of elasticity) of medium or large arteries (from the Greek arteria, meaning artery, and sclerosis, meaning hardening) Atherosclerosis is a hardening of an artery specifically due to an atheromatous plaque. The term atherogenic is used for substances or processes that cause atherosclerosis. Also arterial hyalinosis and arteriolar hyalinosis refers to thickening of the walls of arterioles by the deposits that ...
In the kidneys, as a result of benign arterial hypertension, hyaline (pink, amorphous, homogeneous material) accumulates in the walls of small arteries and arterioles, producing the thickening of their walls and the narrowing of the arterial openings, a process known as arteriolosclerosis. The resulting inadequate blood flow produces tubular atrophy, interstitial fibrosis, and glomerular alterations (smaller glomeruli with different degrees of hyalinization - from mild to sclerosis of glomeruli) and scarring around the glomeruli (periglomerular fibrosis). In advanced stages, kidney failure will occur. Functional nephrons[5] have dilated tubules, often with hyaline casts in the opening of the tubules. Additional complications often associated with hypertensive nephropathy include glomerular damage resulting in protein and blood in the urine. Hypertensive nephropathy refers to kidney failure that can be attributed to a history of hypertension[6] It is a chronic condition and it is a serious risk ...
Arteriosclerosis is a type of coronary artery disease that causes hardening of the arteries. It causes the arteries to experience a loss in elasticity and an increase in stiffness. Hardened arterial walls will cause the blood to move slower through the arteries, while also increasing the chance of damage by high blood pressure. Serious cases of arteriosclerosis may require heart surgery. If left untreated, arteriosclerosis may cause heart attacks and death. Often times, arteriosclerosis is used interchangeably with the term atherosclerosis. However, these are two very different types of coronary artery disease. By definition, atherosclerosis is simply the buildup of plaque in the arteries. Just like arteriosclerosis causes the arterial walls to harden and become stiff, plaque buildups from atherosclerosis also cause a loss of elastin, stiffness, and thickening in the walls of the arteries.. While it is possible for a person to have hardened arteries (arteriolosclerosis) without having arterial ...
TY - JOUR. T1 - Structural and functional changes in human kidneys with healthy aging. AU - Hommos, Musab S.. AU - Glassock, Richard J.. AU - Rule, Andrew D. PY - 2017/10/1. Y1 - 2017/10/1. N2 - Aging is associated with significant changes in structure and function of the kidney, even in the absence of age-related comorbidities.On themacrostructural level, kidney cortical volume decreases, surface roughness increases, and the number and size of simple renal cysts increasewith age.Onthemicrostructural level, the histologic signs of nephrosclerosis (arteriosclerosis/arteriolosclerosis, global glomerulosclerosis, interstitial fibrosis, and tubular atrophy) all increase with age. The decline of nephron number is accompanied by a comparable reduction inmeasured whole-kidney GFR. However, single-nephron GFR remains relatively constant with healthy aging as does glomerular volume. Only when glomerulosclerosis and arteriosclerosis exceed that expected for age is there an increase in single-nephron GFR. ...
TY - JOUR. T1 - Microvascular pathology and morphometrics of sporadic and hereditary small vessel diseases of the brain. AU - Craggs, Lucinda J L. AU - Yamamoto, Yumi. AU - Deramecourt, Vincent. AU - Kalaria, Raj N.. N1 - No record of this in Eprints. HN 29/11/2017. PY - 2014/9. Y1 - 2014/9. N2 - Small vessel diseases (SVDs) of the brain are likely to become increasingly common in tandem with the rise in the aging population. In recent years, neuroimaging and pathological studies have informed on the pathogenesis of sporadic SVD and several single gene (monogenic) disorders predisposing to subcortical strokes and diffuse white matter disease. However, one of the limitations toward studying SVD lies in the lack of consistent assessment criteria and lesion burden for both clinical and pathological measures. Arteriolosclerosis and diffuse white matter changes are the hallmark features of both sporadic and hereditary SVDs. The pathogenesis of the arteriopathy is the key to understanding the ...
Acute tubular necrosis, Arteriolosclerosis (hypertension), Diabetic glomerulosclerosis, Rapidly progressive glomerulonephritis, Eclampsia, Chronic glomerulonephritis, Adult polycystic disease, Acute tubular necrosis from ethylene glycol, Pseudomonas abscesses, Bacterial endocarditis, Acute and chronic pyelonephritis, Coccidiodomycosis, Wilms tumor, Transitional cell carcinoma, Renal cell carcinoma (hypernephroma), Membranous glomerulonephritis, Acute transplant rejection, Systemic lupus erythematosus, Amyloidosis, Septic infarct, Atheroemboli, Nephrocalcinosis, Primary chronic adrenal insufficiency, Polyarteritis, Pheochromocytoma, Nodular hyperplasia, Neuroblastoma, Cortical adenoma, Adrenocortical carcinoma. ...
The location of a primary intracerebral hemorrhage (ICH) plays a large role in identifying the underlying cause and prognosis.1 Deep ICHs, located in the basal ganglia or brainstem, are associated with arteriolosclerosis due to aging, hypertension, and other conventional vascular risk factors, and they have a low rate of recurrence (≈1%/y-2%/y) if blood pressure is well controlled. Lobar ICHs, located in the cortex or underlying white matter, may instead be associated with cerebral amyloid angiopathy (CAA) caused by vascular amyloid deposition and are associated with several-fold higher risk of recurrence. MRI can further risk-stratify patients by identifying microbleeds or cortical superficial siderosis, indicating past asymptomatic bleeding events.1 In patients with lobar ICH, evidence of superficial siderosis or microbleeds restricted exclusively to lobar locations increases the probability that the underlying cause is CAA,2 and they are associated with a high risk for recurrence. ...
Objectives:. The investigators examined whether rosiglitazone, a thiazolidinedione (TZD), is beneficial for pre-diabetes mellitus (DM) adults with documented coronary artery disease (CAD).. Background:. Microvascular and macrovascular complications are common in type 2 DM. There is no evidence about the effects of TZDs, synthetic peroxisome proliferator-activated receptor (PPAR)-γ activators (insulin sensitizers and adipose transcriptional regulation and anti-inflammatory process activators) on pre-DM patients with documented CAD. ...
Can those of you who have kidney involement or know of someone who does tell me what are the symptoms of it? When I had my last urine test in Feb the dr told me I had no protein and no kidney involvement. I have no real swelling and never really did even with all the joint pain. I am feeling pretty good with the plaq its only been two weeks though so still have some mild side affects. However for the past two days I have had this bad lower back pain right above where my pants sit its hard to bend over. I am kind of scared could that be my kidneys I thought it was just back pain like joint pain then my mom had to go and say "what if its kidney problems now" THanks! My urinary habits have not changed or anything but I was not sure what you are suppossed to look for with possible kidney problems. ...
I do remember being pretty freaked out after I had protein in my urine and was worried about my kidneys and kidney damage, but the great people here helped to ease my mind some. I found out that if you do have kidney involvement that it is fairly treatable, especially if it is caught early. If you havent done a 24 hour urine test, it would be worth asking about it. Also, if you have continued problems with protein you can also ask for a referral to a nephrologist who would be the one to tell you if the amount of protein you are spilling is anything to worry about ...
Edema is a common symptom that many IgA Nephropathy patients complain about. How to treat edema? More and more people turn to natural remedies, Micro-Chinese Medicine Osmatherapy is included. What causes edema for IgA Nephropathy patients?
IgA Nephropathy is one common primary glomerular disease, which is marked by repeated gross hematuria. However, due to glomerular inflammation, protein also will be leaked out. How do IgA Nephropathy patients avoid protein leaking again?
Creatinine 673 refer to a medical condition in which the kidneys have been damaged more than 80%. Medically, the patients with creatinine 673 will endure so much discomforts. While, how to reduce high creatinine 673 for IgA Nephropathy patients? As a
Although a forward slash may be used to express a ratio (eg, the male/female [M/F] ratio was 2/1), JAMA and the Archives Journals recommend use of a colon to express ratios involving numbers or abbreviations (the Apo B:Apo A-I ratio was 2:1) and the word to to express ratios involving words (the male to female ratio). (See , Colon, Numbers.) |
Although a forward slash may be used to express a ratio (eg, the male/female [M/F] ratio was 2/1), JAMA and the Archives Journals recommend use of a colon to express ratios involving numbers or abbreviations (the Apo B:Apo A-I ratio was 2:1) and the word to to express ratios involving words (the male to female ratio). (See , Colon, Numbers.) |
The Apo-B/Apo A-1 Ratio Predicts Severity of Coronary Artery Disease. References: Lipid Health Dis, Hunt Study,. I get asked all the time about whether folks should be on a statin, or whether their lipid panel is trouble. They tell me their total cholesterol. Their doctor just told them to be on a statin. What should they do? Now, I say, "Lets look at your lipids and see if you really are at risk. Turns out, your total cholesterol just isnt the issue at all." The HUNT Study from Norway has thrown a significant monkey wrench into the whole affair be discovering that women who have cholesterol above 200 live longer than women below 200. So, why are we treating you to lower your level below 200? What are your real risks?. Along comes the Singulex company and starts with a new test I hadnt seen before, the Apo - B / Apo A-1 ratio. Sounds like a lot of excessive slicing and dicing. So, I did some reading and here is what I found out.. Apo - B is essentially the docking protein of the LDL particle. ...
In the following content, we will introduce you the natural ways to reduce high creatinine level in IgA Nephropathy and they include healthy diet and Chinese medicine therapies. As a patient with IgA Nephropathy, if you are experiencing hig
Summary: Human immunoglobulin A is represented by two structurally and functionally distinct subclasses: IgAl and IgA2. IgAl, which is almost exclusively present in the mesangial deposits in IgA nephropathy patients, contains in its hinge region three to five O-Hned carbohydrate chains. A fraction of IgAl molecules in the circulation of IgA nephropathy patients exhibits aberrant glycosylation. As a result of changes in glycosylation, the neoepitopes represented by glycans are exposed and recognized by naturally occurring antibodies with antiglycan specifities, and immune complexes are generated. The deposits of these immune complexes in the glomerular mesangia elitu inflammatory response known as IgA nephropathy. Epidemiological studies have shown that dominant hematuria, either isolated or combined with mild proteinuria, is the most frequent urinary syndrom in glomerulonephritis. The morphologic finding of this syndrom is most frequently IgA nephropathy. Originally considered a benign disease, ...
As a matter of fact, creatinine 7.8 refers to that your kidney disease is at stage 5 kidney disease which is the end stage of kidney disease. For patients who are at this stage, kidney transplant is often needed for patients to sustain thei
A thermal and chemical degradation approach was followed to determine the precursors of pristane (Pr) and phytane (Ph) in samples from the Gessoso-solfifera, Ghareb and Green River Formations. Hydrous pyrolysis of these samples yields large amounts of Pr and Ph carbon skeletons, indicating that their precursors are predominantly sequestered in high-molecular-weight fractions. However, chemical degradation of the polar fraction and the kerogen of the unheated samples generally does not release large amounts of Pr and Ph. Additional information on the precursors of Pr and Ph is obtained from flash pyrolysis analyses of kerogens and residues after hydrous pyrolysis and after chemical degradation. Multiple precursors for Pr and Ph are recognised in these three samples. The main increase of the Pr/Ph ratio with increasing maturation temperature, which is associated with strongly increasing amounts of Pr and Ph, is probably due to the higher amount of precursors of Pr compared to Ph,...
Is celery juice good for IgA Nephropathy patients? Celery juice reserves nearly all health benefits of celery, so it can help IgA Nephropathy patients improve their healthy condition if eaten correctly. What can IgA Nephropathy patients get
The investigators hypothesize that adjuvant metformin use in breast cancer patients with overweight or pre-diabetes mellitus (DM) may improve their body
BACKGROUND: Activation and consequent phenotypic modulation of mesangial cells is considered to play a crucial role in the process of glomerular disease progression. Caldesmon, a calmodulin and actin-binding protein, is a molecular marker of the phenotypic change in smooth-muscle cells. SUBJECTS AND METHODS: We studied whether the expression of caldesmon in mesangial cells was enhanced in the process of IgA nephropathy and whether it would be a marker of mesangial activation indicating prognostic significance in specific disease states. We performed immunohistochemical staining with anticaldesmon and alpha-smooth-muscle actin (alpha-SMA) antibodies in 32 biopsy specimens from IgA nephropathy patients and analysed them quantitatively with a computer-aided manipulator. RESULTS: The glomerular expression of caldesmon was enhanced in IgA nephropathy patients. We compared caldesmon expression with composite histological scores (cell score and matrix score), clinical parameters and expressions of ...
Sometimes the Diabetic Nephropathy patients suffer from various kinds of the kidney problems. In order to get rid of them, they choose to do the dialysis. While can dialysis really stop kidney problems for diabetic nephropathy patients? Do
Diabetes has all kinds of complications, in most conditions, Long years of uncontrolled diabetes will cause kidney damage, we call it diabetic nephropathy. For diabetic nephropathy patients, a series of symptoms can occur like itchy skin, n
How to deal with the IgA Nephropathy relapse? What the lifespan of IgA Nephropathy patients? Start to find the information of IgA Nephropathy basics, symptoms, treatment, Diet﹠Fitness.
The Diabetic Nephropathy can obtain many notice about this disease. It contains the prevent in early phase, the therapies during the treatment and the
With the improvement of life quality, more and more people get diabetes. After years of diabetes, you may find that your creatinine level increases gradually. How to reduce creatinine 4 for Diabetic Nephropathy patients? In Shijiazhuang Kid
There are two parts to this study, each part includes double-blind treatment with either CTP-499 or placebo. Part 1 will evaluate the safety and efficacy of treatment with CTP-499 twice daily for 24 weeks. Part 2 will evaluate the effects of longer term dosing for an additional 24 weeks. Following Part 2, patients will be allowed to participate in an Open Label extension with CTP-499 for a period of an additional 48 weeks ...
Dr. Goldman responded: Very different . There are differences - especially less kidney involvement, different serology to name some things . It mostly resolves after stopping the drug involved.
TEXTBOOKS. Beers MH, Berkow R, eds. The Merck Manual, 17th ed. Whitehouse Station, NJ: Merck Research Laboratories; 1999:2478. Fauci AS, et al, eds. Harrisons Principles of Internal Medicine, 14th Ed. New York, NY: McGraw-Hill, Inc; 1998:2454, 2480.. Adams, RD, et al, eds. Principles of Neurology. 6th ed. New York, NY: McGraw-Hill, Companies; 1997:986.. Bennett JC, Plum F, eds. Cecil Textbook of Medicine. 20th ed. Philadelphia, PA: W.B. Saunders Co; 1996:2167.. Behrman RE, ed. Nelson Textbook of Pediatrics, 15th ed. Philadelphia, PA: W.B. Saunders Company; 1996:1715, 1754.. Lyon G, et al, eds. Neurology of Hereditary Metabolic Diseases in Childhood. 2nd ed. New York, NY: McGraw-Hill Companies; 1996:256.. Menkes JH, au, Pine JW, et al, eds. Textbook of Child Neurology, 5th ed. Baltimore, MD: Williams & Wilkins; 1995:852-853.. Scriver CR, et al, eds. The Metabolic and Molecular Basis of Inherited Disease. 7th Ed. New York, NY; McGraw-Hill Companies, Inc; 1995:1562-1564. Buyse ML, ed. Birth ...
Hypertensive Nephropathy is a secondary disease caused by long-standing high blood pressure. Here the article will offer some simple things that you can do to delay your renal damage.
U.S. Pharmacist is a monthly journal dedicated to providing the nations pharmacists with up-to-date, authoritative, peer-reviewed clinical articles relevant to contemporary pharmacy practice in a variety of settings, including community pharmacy, hospitals, managed care systems, ambulatory care clinics, home care organizations, long-term care facilities, industry and academia. The publication is also useful to pharmacy technicians, students, other health professionals and individuals interested in health management. Pharmacists licensed in the U.S. can earn Continuing Education credits through Postgraduate Healthcare Education, LLC, accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. Copyright © 2000 - 2017 Jobson Medical Information LLC unless otherwise noted.. All rights reserved. Reproduction in whole or in part without permission is prohibited.. ...
Some Diabetic Nephropathy patients consider vegetarian diet is a better diet for them. Other patients think that so long as they do not eat meat, milchigs or eggs, it will be ok. However, they neglect that vegetarian diet also contains vegetable protein. If they take vegetarian diet for a long term, it will aggravate burden to kidney. Because vegetable protein contains much of unnecessary amino acid, it cannt meet the need of body and will be metabolized into masses of nitrogen products. Diabetic Nephropathy patients have a poor renal function and it can not well discharge excess water and waste products, so patients should take high-quality protein diet to meet the need of the body without producing masses of nitrogen products ...
Adiposity is known to be related to asthma. Although a causal link between adiponectin (a protein produced by adipose tissue) and asthma has been demonstrated in mice,. Low serum adiponectin levels predict an increased future risk for developing asthma in middle-aged women, particularly among smokers, according to a new study.. the evidence in humans has been conflicting," said lead author Akshay Sood, MD, MPH, associate professor in the Division of Pulmonary and Critical Care Medicine at the University of New Mexico Health Sciences Center School of Medicine.. "In an earlier cross-sectional study, we found an association between low serum adiponectin levels and prevalent asthma among women, but the direction of this association is not known," Dr. Sood continued. "In the current study, we examined the longitudinal association between asthma and adiponectin and found that low serum adiponectin concentrations, independent of obesity, predicted a higher risk for developing asthma.". The findings ...
Since YF is a mosquito-borne disease, its eradication can be quite challenging, due to the presence of a sylvatic cycle of this disease, making it a serious public health problem worldwide1 , 5 , 14 . Having a mosquito as a vector makes YF hard to be eradicated, justifying why it is essential to act on vector control measures14 , 37 .. In 1927, the yellow fever virus strain Asibi isolated from a patient in Ghana was used to formulate the first vaccine. The Asibi strain underwent serial passages in chicken tissue cultures to be attenuated for human use as a vaccine, named the 17D vaccine. There are two types of sub-strains obtained from the 17D vaccine, the 17DD and 17D-204. The 17D strain was first used in Brazil in 1937 for vaccination purposes, and since then The Oswald Cruz Foundation has produced the yellow fever 17DD (YF-17D) vaccine. To produce the 17DD vaccine, a sample of the yellow fever virus is inoculated into pathogens-free embryonated chicken eggs, as recommended by the WHO14 , 18 ...
Two low-molecular-weight fractions of sodium hyaluronate (Na-HA), denominated Hyalastin® and Hyalectin®, were investigated as potential adjuvants for ophthalmic vehicles containing pilocarpine nitrate (PiN). Tests were also performed on an ionic complex (HA/PiB) prepared from hyaluronic acid (derived from Hyalastin®) and pilocarpine base. The performance of the vehicles under study was verified by miosis and ocular retention tests carried out on albino rabbits, against a series of reference vehicles, three of which contained a high-molecular-weight fraction of Na-HA (Healon®). The group of 14 reference and test preparations exhibited Newtonian or pseudoplastic flow characteristics and encompassed a wide range of apparent viscosities (1 to 1054 mPa s). The results indicate that the HA/PiB salt and the high-MW Na-HA can significantly increase the bioavailability of pilocarpine with respect to reference vehicles of comparable viscosity: an effect that can be reasonably attributed to ...
Proteinuria and renin-angiotensin-aldosterone system inhibitors are independently associated with a significant 6-fold increased odds for anemia in patients with diabetic nephropathy.
The Renal Lupus Clinic is an outpatient clinic located at the Lupus Center of Excellence of UPMC where patients with kidney involvement from autoimmune diseases such as systemic lupus erythematosus (SLE), vasculitis, and other glomerulonephritis (GN) diseases are evaluated. Occasionally, patients with other kidney diseases (not related to lupus or other GN) may also be seen at this clinic. The center is equipped with a laboratory, allowing bloodwork and urine analysis to be done on site. Patients with lupus may see one of several rheumatologists as well as a nephrologist, with care coordinated so that clinic appointments can often be arranged on the same day amongst specialists if desired ...
Essential guide to the basics of pre-diabetes. Learn more about the risks, symptoms and treatment of pre-diabetes and learn how to prevent pre-diabetes and type 2 diabetes.
Charles Darwins Illness - One step Forward, One step Back.. The diagnosis of Darwins illness may perhaps be moved forward and the actual mtDNA mutation that was the cause of his illness identified. The alternate diagnoses that have been suggested, in particular those of lactose intolerance and a Meniere type disorder can be explained by the same mutation. Darwins illness may also be traced back a further generation to his mothers mother who had symptoms herself as well as three, perhaps four afflicted children.[1]. As well as symptoms that are commonly associated with CVS Darwin had several other symptoms, symptoms not seen in CVS - episodes of memory loss and partial paralysis.[2] These were stroke-like episodes, characteristic of the MELAS syndrome.[3] Headaches, visual disturbances, peripheral neuropathy and abdominal pain may occur in patients with CVS but also occur in the MELAS syndrome. 80% of patients with the MELAS syndrome have an A3243G mtDNA mutation; the same mutation has been ...
Results We reviewed a total of 106 patients with SLE, with a mean age of 34.7 ± 13.2 and 95% were female. A history of BCG was found in 90% and 84% presented a scar. Only 8% reported contact with TB patients and 12% were employees or residents of health or correctional institutions. A previous PPD was reported in 8%, of which 11% had a positive result. The 4% with previous diagnosis of TB had received treatment, 75% with lung and 25% with kidney involvement. Comorbidities: 28.3% with hypertension, 2.8% diabetes mellitus and 16% with dyslipidemia. In the present study 9% had a positive PPD, with an average of 5.53 ± 1.92 mm. The QFT-GIT test reported 14% positive, 10% indeterminate and 76% negative. The latter test average was 1.77 ± 0.68 IU / ml in general, 3.14 ± 2.85 in the group of patients with a positive test, 1.41 ± 3.04 in the indeterminate and 0.11 ± 0.11 in the negative group. A correlation between positive results of the two tests was 0.24.. ...
Feeling CEREBROVASCULAR ACCIDENT while using Lexapro? CEREBROVASCULAR ACCIDENT Causes, Patient Concerns and Latest Treatments and Lexapro Reports and Side Effects.
Care guide for Cerebrovascular Accident. Includes: possible causes, signs and symptoms, standard treatment options and means of care and support.
I have been a stay at home mom for about a year and a half now. I am learning more and more to survive on a small budget and coupons is a huge part of that. Living in an apartment I am not able to stockpile as others do, but I still get the freebies and lots of good deals ...
TY - JOUR. T1 - Can intestinal pseudo-obstruction drive recurrent stroke-like episodes in late-onset MELAS syndrome? A case report and review of the literature. AU - Gagliardi, Delia. AU - Mauri, Eleonora. AU - Magri, Francesca. AU - Velardo, Daniele. AU - Meneri, Megi. AU - Abati, Elena. AU - Brusa, Roberta. AU - Faravelli, Irene. AU - Piga, Daniela. AU - Ronchi, Dario. AU - Triulzi, Fabio. AU - Peverelli, Lorenzo. AU - Sciacco, Monica. AU - Bresolin, Nereo. AU - Comi, Giacomo Pietro. AU - Corti, Stefania. AU - Govoni, Alessandra. PY - 2019/1/1. Y1 - 2019/1/1. N2 - Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a maternally inherited mitochondrial disorder that is most commonly caused by the m. 3243A,G mutation in the MT-TL1 mitochondrial DNA gene, resulting in impairment of mitochondrial energy metabolism. Although childhood is the typical age of onset, a small fraction (1-6%) of individuals manifest the disease after 40 years of age and usually ...
Obesity is associated with impaired coronary collateral vessel development. Yilmaz, M.B.; Biyikoglu, S.F.; Akin, Y.; Guray, U.; Kisacik, H.L.; Korkmaz, S. // International Journal of Obesity & Related Metabolic Disorders;Dec2003, Vol. 27 Issue 12, p1541 BACKGROUND:: Chronic myocardial ischaemia due to coronary artery stenosis or occlusion has been shown to increase the growth of coronary collateral circulation. Collateralization leads to increased oxygen delivery to the area at risk and hence may reduce ischaemia, prevent infarction and... ...
The results of the present experiments establish that angiogenesis is impaired as a function of age. The reduced capability for collateral vessel development in response to ischemia was confirmed in 2 different animal models. The ultimate hindlimb BPR achieved at 40 days after surgery was significantly less in old than in young NZW rabbits. In old mice, perfusion of the ischemic hindlimb, reflected by the Doppler flow ratio, was significantly reduced compared with young mice; this difference was apparent as soon as 7 days after surgery and persisted throughout the duration (28 days) of the study. Likewise, the number of blood vessels that were angiographically visible in rabbits and the number of capillaries per unit area identified histologically in mice and rabbits were both significantly reduced in old versus young animals. The latter finding is consistent with the observation that myocardial angiogenesis related to left ventricular hypertrophy is attenuated in an age-dependent manner.20 The ...
In many countries, the diabetic nephropathy patients with creatinine 5.4 have been on dialysis because of the serious complications. After realizing the side effects of dialysis, more and more diabetic nephropathy patients want to know that
Is Cerebrovascular Accident a common side effect of Cardensiel? View Cerebrovascular Accident Cardensiel side effect risks. Female, 77 years of age, was diagnosed with myeloma recurrence and took Cardensiel Oral.
Primary mitochondrial diseases (MD) are complex, heterogeneous inherited diseases caused by mutations in either the mitochondrial or nuclear DNA. Glomerular diseases in MD have been reported with tRNA mutation m.3243A,G causing a syndrome of mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS). We describe here a case of focal segmental glomerulosclerosis (FSGS) associated with a new tRNA mutation site. A 34-year-old man with a history of living related kidney transplantation, diabetes, hearing loss, and developmental delay presented to the outpatient clinic with complaints of new behavioral difficulties, worsening symptoms, and brain involvement on imaging ...
Arteriolosclerosis, unlike atherosclerosis, is a sclerosis that only affects small arteries and arterioles, which carry ...
Arteriolosclerosis. This affects the body's smaller arteries.[3]. The effects of arteriosclerosis can lead to lack of regular ...
Hyaloserositis Hyaline arteriolosclerosis IMA Mycological Glossary: Hyaline. Taber's Cyclopedic Medical Dictionary, 19th ...
Arteriolosclerosis is the term specifically used for the hardening of arteriole walls. This can be due to decreased elastic ... An increase in the media to lumenal diameter ratio has been observed in hypertensive arterioles (arteriolosclerosis) as the ...
... arteriolosclerosis is any hardening (and loss of elasticity) of arterioles (small arteries); atherosclerosis is a hardening of ... arteriolosclerosis, and atherosclerosis. Arteriosclerosis is a general term describing any hardening (and loss of elasticity) ...
... hyaline arteriolosclerosis). Under a microscope, this appears as a homogeneous, pink hyaline thickening at the expense of the ...
Monckeberg's arteriosclerosis and arteriolosclerosis). In the context of heart or artery matters, atheromata are commonly ...
The changes in small arterioles include hyaline arteriolosclerosis (deposition of hyaline, collagenous material),[citation ... a process known as arteriolosclerosis. The resulting inadequate blood flow produces tubular atrophy, interstitial fibrosis, and ...
Atherosclerosis arteriolosclerosis arteriosclerosis arteriosclerotic vascular disease atheroma (I71) Aortic aneurysm and ...
... arteriosclerosis and arteriolosclerosis - to narrow which arteries are diseased and can easily be confused due to similar ...
... arteriolosclerosis MeSH C14.907.137.126.114 --- arteriosclerosis obliterans MeSH C14.907.137.126.307 --- atherosclerosis MeSH ...
Types include hyaline arteriolosclerosis and hyperplastic arteriolosclerosis, both involved with vessel wall thickening and ... Play media Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of arterioles or ... It is a type of arteriolosclerosis, which refers to thickening of the arteriolar wall and is part of the ageing process. ... This is a type of arteriolosclerosis involving a narrowed lumen. The term "onion-skin" is sometimes used to describe this form ...
Exercise can improve symptoms, as can revascularization.[4] Both together may be better than one intervention of its own.[4] Pharmacological options exist, as well. Medicines that control lipid profile, diabetes, and hypertension may increase blood flow to the affected muscles and allow for increased activity levels. Angiotensin converting enzyme inhibitors, adrenergic agents such as alpha-1 blockers and beta-blockers and alpha-2 agonists, antiplatelet agents (aspirin and clopidogrel), naftidrofuryl, pentoxifylline, and cilostazol (selective PDE3 inhibitor) are used for the treatment of intermittent claudication.[5] However, medications will not remove the blockages from the body. Instead, they simply improve blood flow to the affected area.[6] Catheter-based intervention is also an option. Atherectomy, stenting, and angioplasty to remove or push aside the arterial blockages are the most common procedures for catheter-based intervention. These procedures can be performed by interventional ...
The resulting ischemia prompts further release of vasoactive substances including prostaglandins, free radicals, and thrombotic/mitotic growth factors, completing a vicious cycle of inflammatory changes.[9] If the process is not stopped, homeostatic failure begins, leading to loss of cerebral and local autoregulation, organ system ischemia and dysfunction, and myocardial infarction.[10] Single-organ involvement is found in approximately 83% of hypertensive emergency patients, two-organ involvement in about 14% of patients, and multi-organ failure (failure of at least 3 organ systems) in about 3% of patients. In the brain, hypertensive encephalopathy - characterized by hypertension, altered mental status, and swelling of the optic disc - is a manifestation of the dysfunction of cerebral autoregulation.[7] Cerebral autoregulation is the ability of the blood vessels in the brain to maintain a constant blood flow. People who suffer from chronic hypertension can tolerate higher arterial pressure ...
Yet another related disorder causing hypertension is glucocorticoid remediable aldosteronism, which is an autosomal dominant disorder in which the increase in aldosterone secretion produced by ACTH is no longer transient, causing of primary hyperaldosteronism, the Gene mutated will result in an aldosterone synthase that is ACTH-sensitive, which is normally not.[22][23][24][25][26] GRA appears to be the most common monogenic form of human hypertension.[27] Compare these effects to those seen in Conn's disease, an adrenocortical tumor which causes excess release of aldosterone,[28] that leads to hypertension.[29][30][31] Another adrenal related cause is Cushing's syndrome which is a disorder caused by high levels of cortisol. Cortisol is a hormone secreted by the cortex of the adrenal glands. Cushing's syndrome can be caused by taking glucocorticoid drugs, or by tumors that produce cortisol or adrenocorticotropic hormone (ACTH).[32] More than 80% of patients with Cushing's syndrome develop ...
The vertebral arteries arise from the subclavian artery, and run through the transverse foramen of the upper six vertebrae of the neck. After exiting at the level of the first cervical vertebra, its course changes from vertical to horizontal, and then enters the skull through the foramen magnum. Inside the skull, the arteries merge to form the basilar artery, which joins the circle of Willis. In total, three quarters of the artery are outside the skull; it has a high mobility in this area due to rotational movement in the neck and is therefore vulnerable to trauma. Most dissections happen at the level of the first and second vertebrae. The vertebral artery supplies a number of vital structures in the posterior cranial fossa, such as the brainstem, the cerebellum and the occipital lobes. The brainstem harbors a number of vital functions (such as respiration) and controls the nerves of the face and neck. The cerebellum is part of the diffuse system that coordinates movement. Finally, the occipital ...
Aneurysm means an outpouching of a blood vessel wall that is filled with blood. Aneurysms occur at a point of weakness in the vessel wall. This can be because of acquired disease or hereditary factors. The repeated trauma of blood flow against the vessel wall presses against the point of weakness and causes the aneurysm to enlarge.[12] As described by the Law of Young-Laplace, the increasing area increases tension against the aneurysmal walls, leading to enlargement.. Both high and low wall shear stress of flowing blood can cause aneurysm and rupture. However, the mechanism of action is still unknown. It is speculated that low shear stress causes growth and rupture of large aneurysms through inflammatory response while high shear stress causes growth and rupture of small aneurysm through mural response (response from the blood vessel wall). Other risk factors that contributes to the formation of aneurysm are: cigarette smoking, hypertension, female gender, family history of cerebral aneurysm, ...
The first priority in suspected or confirmed pituitary apoplexy is stabilization of the circulatory system. Cortisol deficiency can cause severe low blood pressure.[1][6] Depending on the severity of the illness, admission to a high dependency unit (HDU) may be required.[1] Treatment for acute adrenal insufficiency requires the administration of intravenous saline or dextrose solution; volumes of over two liters may be required in an adult.[6] This is followed by the administration of hydrocortisone, which is pharmaceutical grade cortisol, intravenously or into a muscle.[4][6] The drug dexamethasone has similar properties,[6] but its use is not recommended unless it is required to reduce swelling in the brain around the area of hemorrhage.[1] Some are well enough not to require immediate cortisol replacement; in this case, blood levels of cortisol are determined at 9:00 AM (as cortisol levels vary over the day). A level below 550 nmol/l indicates a need for replacement.[1] The decision on ...
Evidence supports the use of heparin in people following surgery who have a high risk of thrombosis to reduce the risk of DVTs; however, the effect on PEs or overall mortality is not known.[27] In hospitalized non-surgical patients, mortality does not appear to change.[28][29][30] It does not appear, however, to decrease the rate of symptomatic DVTs.[28] Using both heparin and compression stockings appears better than either one alone in reducing the rate of DVT.[31] In hospitalized people who have had a stroke and not had surgery, mechanical measures (compression stockings) resulted in skin damage and no clinical improvement.[28] Data on the effectiveness of compression stockings among hospitalized non-surgical patients without stroke is scarce.[28] The American College of Physicians (ACP) gave three strong recommendations with moderate quality evidence on VTE prevention in non-surgical patients: that hospitalized patients be assessed for their risk of thromboembolism and bleeding before ...
Fibrinolysis is the physiological breakdown of blood clots by enzymes such as plasmin. Organisation: following the thrombotic event, residual vascular thrombus will be re-organised histologically with several possible outcomes. For an occlusive thrombus (defined as thrombosis within a small vessel that leads to complete occlusion), wound healing will reorganise the occlusive thrombus into collagenous scar tissue, where the scar tissue will either permanently obstruct the vessel, or contract down with myofibroblastic activity to unblock the lumen. For a mural thrombus (defined as a thrombus in a large vessel that restricts the blood flow but does not occlude completely), histological reorganisation of the thrombus does not occur via the classic wound healing mechanism. Instead, the platelet-derived growth factor degranulated by the clotted platelets will attract a layer of smooth muscle cells to cover the clot, and this layer of mural smooth muscle will be vascularised by the blood inside the ...
The exact cause of venous ulcers is not certain, but they are thought to arise when venous valves that exist to prevent backflow of blood do not function properly, causing the pressure in veins to increase.[6][7][8][9] The body needs the pressure gradient between arteries and veins in order for the heart to pump blood forward through arteries and into veins. When venous hypertension exists, arteries no longer have significantly higher pressure than veins, and blood is not pumped as effectively into or out of the area.[6][7][8][9] Venous hypertension may also stretch veins and allow blood proteins to leak into the extravascular space, isolating extracellular matrix (ECM) molecules and growth factors, preventing them from helping to heal the wound.[6][9] Leakage of fibrinogen from veins as well as deficiencies in fibrinolysis may also cause fibrin to build up around the vessels, preventing oxygen and nutrients from reaching cells.[6] Venous insufficiency may also cause white blood cells ...
Based on these studies, treating to a systolic blood pressure of 140, as long as the diastolic blood pressure is 68 or more, seems safe.[citation needed] Corroborating this, a reanalysis of the SHEP data suggests allowing the diastolic to go below 70 may increase adverse effects.[4] A meta-analysis of individual patient data from randomized controlled trials found the lowest diastolic blood pressure for which cardiovascular outcomes improve is 85 mm Hg for untreated hypertensives and 80 mm Hg for treated hypertensives.[5] The authors concluded "poor health conditions leading to low blood pressure and an increased risk for death probably explain the J-shaped curve".[5] Interpreting the meta-analysis is difficult, but avoiding a diastolic blood pressure below 68-70 mm Hg seems reasonable because: ...
... (also known as "Mondor's syndrome of superficial thrombophlebitis"[2]) is a rare condition which involves thrombophlebitis of the superficial veins of the breast and anterior chest wall. It sometimes occurs in the arm or penis.[3] In axilla, this condition is known as axillary web syndrome.[4]. Patients with this disease often have abrupt onset of superficial pain, with possible swelling and redness of a limited area of their anterior chest wall or breast. There is usually a lump present, which may be somewhat linear and tender. Because of the possibility of the lump being from another cause, patients are often referred for mammogram and/or breast ultrasound.[5]. Mondor's disease is self-limiting and generally benign. A cause is often not identified, but when found includes trauma, surgery, or inflammation such as infection. There have been occasional cases of associated cancer.[6] Management is with warm compresses and pain relievers, most commonly NSAIDS such as ibuprofen. ...
Hirsch, Alan T.; Haskal, Ziv J.; Hertzer, Norman R.; Bakal, Curtis W.; Creager, Mark A.; Halperin, Jonathan L.; Hiratzka, Loren F.; Murphy, William R.C.; Olin, Jeffrey W.; Puschett, Jules B.; Rosenfield, Kenneth A.; Sacks, David; Stanley, James C.; Taylor, Lloyd M.; White, Christopher J.; White, John; White, Rodney A.; Antman, Elliott M.; Smith, Sidney C.; Adams, Cynthia D.; Anderson, Jeffrey L.; Faxon, David P.; Fuster, Valentin; Gibbons, Raymond J.; Halperin, Jonathan L.; Hiratzka, Loren F.; Hunt, Sharon A.; Jacobs, Alice K.; Nishimura, Rick; et al. (2006). "ACC/AHA 2005 Guidelines for the Management of Patients With Peripheral Arterial Disease (Lower Extremity, Renal, Mesenteric, and Abdominal Aortic): A Collaborative Report from the American Association for Vascular Surgery/Society for Vascular Surgery,⁎ Society for Cardiovascular Angiography and Interventions, Society for Vascular Medicine and Biology, Society of Interventional Radiology, and the ACC/AHA Task Force on Practice Guidelines ...
Evidence supports the use of heparin in people following surgery who have a high risk of thrombosis to reduce the risk of DVTs; however, the effect on PEs or overall mortality is not known.[22] In hospitalized non-surgical patients, mortality decreased but not statistically significant.[23][24] It does not appear however to decrease the rate of symptomatic DVTs.[23] Using both heparin and compression stockings appears better than either one alone in reducing the rate of DVT.[25]. In hospitalized people who have had a stroke and not had surgery, mechanical measures (compression stockings) resulted in skin damage and no clinical improvement.[23] Data on the effectiveness of compression stockings among hospitalized non-surgical patients without stroke is scarce.[23]. The American College of Physicians (ACP) gave three strong recommendations with moderate quality evidence on VTE prevention in non-surgical patients: that hospitalized patients be assessed for their risk of thromboembolism and bleeding ...
Types include hyaline arteriolosclerosis and hyperplastic arteriolosclerosis, both involved with vessel wall thickening and ... Play media Arteriolosclerosis is a form of cardiovascular disease involving hardening and loss of elasticity of arterioles or ... It is a type of arteriolosclerosis, which refers to thickening of the arteriolar wall and is part of the ageing process. ... This is a type of arteriolosclerosis involving a narrowed lumen. The term "onion-skin" is sometimes used to describe this form ...
Antonyms for arteriolosclerosis. 2 words related to arteriolosclerosis: induration, sclerosis. What are synonyms for ... arteriolosclerosis. Also found in: Dictionary, Medical, Encyclopedia.. Related to arteriolosclerosis: hypertension, stroke ... Arteriolosclerosis synonyms, arteriolosclerosis antonyms - FreeThesaurus.com https://www.freethesaurus.com/arteriolosclerosis. ... Hyaline arteriolosclerosis is more pronounced in patients with diabetes than it is in patients with any other disease, except ...
arteriolosclerosis answers are found in the Tabers Medical Dictionary powered by Unbound Medicine. Available for iPhone, iPad ... arteriolosclerosis is a topic covered in the Tabers Medical Dictionary. To view the entire topic, please sign in or purchase a ... "Arteriolosclerosis." Tabers Medical Dictionary, 23rd ed., F.A. Davis Company, 2017. Nursing Central, nursing.unboundmedicine. ... com/nursingcentral/view/Tabers-Dictionary/752483/all/arteriolosclerosis. Arteriolosclerosis. In: Venes D, ed. Tabers Medical ...
Arteriolosclerosis, unlike atherosclerosis, is a sclerosis that only affects small arteries and arterioles, which carry ...
Genetic Susceptibility for Ischemic Infarction and Arteriolosclerosis Based on Neuropathologic Evaluations ... Supplementary Material for: Genetic Susceptibility for Ischemic Infarction and Arteriolosclerosis Based on Neuropathologic ... The diabetes risk variant rs864745 within JAZF1 was associated with arteriolosclerosis (OR = 0.80, p = 0.014). We observed ... or macroscopic infarcts and with arteriolosclerosis. Methods: Measures of neuropathology and genotyping were available from 755 ...
Triple Threat: Tau, Atrophy, and Arteriolosclerosis Push CTE Toward Dementia *Add To My AlzForum ... Among former National Football League players who died with CTE, tau tangles, crumbling white matter, and arteriolosclerosis ...
Triple Threat: Tau, Atrophy, and Arteriolosclerosis Push CTE Toward Dementia *Add To My AlzForum ... Among former National Football League players who died with CTE, tau tangles, crumbling white matter, and arteriolosclerosis ...
How do we stop heart disease (Atherosclerosis, Arteriolosclerosis, Arteriosclerosis, calcification). Discussion in General ...
Focal arteriolosclerosis, mild GBM thickening. * ↵*Estimated based on proteinuria of 3.6 g/day. ...
76 Arteriolosclerosis. Nonatheromatous Vasculopathy. 77 Aberrant Internal Carotid Artery. 78 Persistent Carotid Basilar ...
Hyaline arteriolosclerosis (change consistent with longstanding hypertension) *Glomerulosclerosis (changes typically caused by ...
Arteriolosclerosis. This affects the bodys smaller arteries.[3]. The effects of arteriosclerosis can lead to lack of regular ...
Huchard H: Arteriolosclerosis: including its cardiac form. JAMA 1909, 53:1129.Google Scholar ...
So hyaline arteriolosclerosis. Well, why is this bad? Well, you can imagine that, if the hypertension is long-standing, then ... So this process of the smaller blood vessel undergoing thickening is called hyaline arteriolosclerosis. So thats quite a ...
It is used as an adjunct in the management of primary hypercholesterolemia; regression of arteriolosclerosis; relief of ...
hyaline arteriolosclerosis. hyaline thickening, benign nephrosclerosis. hyperplastic arteriolosclerosis. onion-skin appearance ... Arteriolosclerosis. affects small arteries and arterioles; hylaine and hyperplastic; assoc with hypertension and DM. ... Mnckebergs arteriosclerosis, Arteriolosclerosis, Atherosclerosis. Monckebergs arteriosclerosis. medial calcific sclerosis; ...
Retinal arteriolosclerosis 35 Thickening of the basement membrane of the epithelium of the pars plicata of the ciliary body is ...
Presence of small vessel disease like hyaline arteriolosclerosis 47 In which sites is hypertensive haemorrhage likely to occur ...
hyperplastic arteriolosclerosis caused by.. describe it. what is it consist of (2) ...
1) Monckeberg (2) Arteriolosclerosis (3) Atherosclerosis 13 What is Monckeberg arteriosclerosis, and where is it especially ...
Define: 1. Hyaline arteriolosclerosis 2. Hyperplastic arteriolosclerosis. What is Arteriosclerosis?. general term of 3 types of ... what is Arteriolosclerosis? Dz. of small arteries & arterioles. occurs often w/ hypertension & diabetes mellitus. ...
Hyaloserositis Hyaline arteriolosclerosis IMA Mycological Glossary: Hyaline. Tabers Cyclopedic Medical Dictionary, 19th ...
A morphometric correlation with arteriolosclerosis and dilated perivascular spaces. Brain1991;114:761-74. ... Significance of white matter high intensity lesions as a predictor of stroke from arteriolosclerosis. J Neurol Neurosurg ...
Study Congenital heart defects flashcards from Hoi Wan
  • The following two terms whilst similar, are distinct in both spelling and meaning and may easily be confused with arteriolosclerosis. (wikipedia.org)
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