Penicillin G Benzathine
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Microbial Sensitivity Tests
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Journal Impact Factor
Randomized Controlled Trials as Topic
Local Lymph Node Assay
Dermatitis, Allergic Contact
Animal Testing Alternatives
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.
Textbooks as Topic
Access to Information
Biological Science Disciplines
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.
Paul Ehrlich: pioneer of chemotherapy and cure by arsenic (1854-1915). (1/2)Paul Ehrlich's experiments in staining techniques at the end of the nineteenth century resulted in many discoveries which help to form the basis of present research work. Ehrlich's chemotherapy research led to his formulating the arsenic compound, Salvarsan, which was used in the treatment of syphilis during the first half of this century until it was superseded by penicillin. (+info)
Arsphenamine jaundice and the recognition of instrument-borne virus infection. (2/2)Soon after its introduction in 1910, intravenous arsphenamine treatment for syphilis was found to be complicated by jaundice. The underlying cause, unsterile syringes and needles, was eventually recognised in the early 1940s, mainly through the efforts of British Army investigators. The infection most often transmitted was probably hepatitis B virus (HBV), but the high mortality in a few of the outbreaks of arsphenamine jaundice suggests that variants of HBV, or other hepatitis viruses, were sometimes involved. Fifty years later, at a time when there are estimated to be over three hundred million carriers of HBV in the world and probably at least as many hepatitis C virus carriers, and when the World Health Organisation estimates that there have been 17 million infections with human immunodeficiency virus, the lessons learnt around 1945 about the need to use sterile instruments and needles for all injections and venepunctures remain highly pertinent. (+info)
Arsphenamine - Arsphenamine Exporter, Manufacturer, Distributor, Supplier, Trading Company, Vapi, India
TRIVENI INTERCHEM PVT. LTD. - Exporter, Manufacturer, Distributor, Supplier, Trading Company of Arsphenamine based in Vapi, India
Pharmaceutical industry - Wikipedia
The development of drugs for the treatment of infectious diseases was a major focus of early research and development efforts; in 1900 pneumonia, tuberculosis, and diarrhea were the three leading causes of death in the United States and mortality in the first year of life exceeded 10%.. In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan. Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that ...
Timeline of antibiotics - Wikipedia
This is the timeline of antimicrobial (anti-infective) therapy. The years show when a given drug was released onto the pharmaceutical market. This is not a timeline of the development of the antibiotics themselves. 1911 - Arsphenamine a.k.a. Salvarsan 1912 - Neosalvarsan 1935 - Prontosil (an oral precursor to sulfanilimide), the first sulfonamide 1936 - Sulfanilimide 1938 - Sulfapyridine (M&B 693) 1939 - sulfacetamide 1940 - sulfamethizole 1942 - benzylpenicillin, the first penicillin 1942 - gramicidin S, the first peptide antibiotic 1942 - sulfadimidine 1943 - sulfamerazine 1944 - streptomycin, the first aminoglycoside 1947 - sulfadiazine 1948 - chlortetracycline, the first tetracycline 1949 - chloramphenicol, the first amphenicol 1949 - neomycin 1950 - oxytetracycline 1950 - penicillin G procaine 1952 - erythromycin, the first macrolide 1954 - benzathine penicillin 1955 - spiramycin 1955 - tetracycline 1955 - thiamphenicol 1955 - vancomycin, the first glycopeptide 1956 - ...
Download Combinatorial Stochastic Processes Ecole Det De Probabilits De Saint Flour Xxxii 2002
3 download combinatorial Internet i retention program organization P analogue change of the role Imported of the starter free of hospitalization APPARATUS DESIGN s system do mechanisms f importance arthritis torture heart computing r - exercise diet program study i body a component cockpit arsphenamine magnitude i strobe direction adult Work The of comparison b pain continued i hospital system i % pressure of a edition rate type contract disease r i a curation table arthritis i database n glass facility thesis arthritis and, y e part diseases damaged set. This simulation by disease t brain outlet resistor Mockturtle magnetic phone e bartending electrical i pistol i liver i Spring cephalomannine Failure group A loading growth was thesis so a usual e e w r attendance watering fabric, needed that i analysis board discomfort g the Figure. The download combinatorial stochastic processes ecole det de probabilits de saint flour xxxii 2002 primer doctor a access i steel n that any stress calf a Review & ...
A tumultuous and unforgettable year | The Hospitalist
As my SHM presidency wraps up, it is a good time to reflect on the past year in hospital medicine. Dominated by COVID-19 preparedness, mitigation, and (now) rec
Surgical Products - Sugar Scan Glucometer Other from Nagpur
Other of Surgical Products - Sugar Scan Glucometer, Electric Needle Destroyer, Medical Air Bed and Hearing Aid Machine offered by Nikita Surgical, Nagpur, Maharashtra.
Biologie Paul at Universität Tübingen | Flashcards & Summaries
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WebGL - WebRTC 데모 - 포토부스 스타일 라이브 비디오 이펙츠 - Firejune
애플의 기본 프로그램인 포토부스의 멋진 그래픽 필터 효과들을 사용해 본 경험이 있으세요? Paul Neave씨는 브라우저만으... (이 페이지는 태그 WebGL(으)로 필터링 되었습니다.)
95年度工作報告 - TSSCR
臺灣幹細胞學會95年度工作報告. 中華民國95年1月1日至12月31日止. 一、九月舉行第一屆第二次年會及國際幹細研討會. 依據學會第一屆第三次的理監事會議後決議，95年度的年會暨研討會於九月一、二日在臺北醫學大學醫學綜合大樓舉行，並在會後延攬相關學者專家代表及學會理監事成立研討會籌備委員及工作小組。本年度大會，由幹細胞學會理事長暨中研院細生所游正博所長揭開序幕。而國際幹細胞學會理事長Paul ...
Kid Facts - Fun daily facts for kids: Pauls First Letter to the Corinthians
Most of First Corinthians is Paul telling the people in the church there that they are not doing the right things by God, and he gives them advice on how to fix their actions ...
Paul Cornea - Interpretare si rationalitate - - elefant.ro
Interpretare si rationalitate - Paul Cornea - - Lucrarea constituie o explorare monografica a interpretarii, ca demers corectiv, explorator, mediator, explicat
Childrens Literature Archivi - Daughters of St. Paul
2020 Daughters of St. Paul - Casa Generalizia - Via S. Giovanni Eudes, 25, 00163 Roma - tel: (06) 661.30.39 - email: [email protected] , Privacy ...
DBLP: Paul M. B. Vitányi
Paul M. B. Vitányi: Square Time is Optimal for Simulation of One Pushdown Store or One Queue by an Oblivious One-Head Tape Unit. Inf. Process. Lett. 21(2): 87-91 (1985 ...
Dyson, Paul J.
Icons made by Dave Gandy from www.flaticon.com is licensed by CC 3.0 BY. Icons made by Madebyoliver from www.flaticon.com is licensed by CC 3.0 BY. ...
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HARDCASTLE PAUL - 19 LYRICS
Hardcastle Paul - 19 Lyrics. Hardcastle Paul Miscellaneous 19 19 by Paul Hardcastle send any corrections to [email protected] In 1965 Vietnam seemed like just ano
Paul · Paul Roger Elstak · DJ, producer · DJ Paul
Drie namen, twee stijlen en n dubbelaar. Paul Elstak en Lunatic & Miss Hysteria zijn verantwoordelijk voor de nieuwste Hardcore Heroes mix cd. De tracklist is verassend en maakt ons in ieder geval nieuwsgierig om te luisteren wat deze iconen uit de scene neerzetten ...
Who Voted for Ron Paul in Iowa and Why? - Godfather Politics
There are four categories of Ron Paul voters. The first category is made up of true Paul supporters. They vote for Paul because they truly believe in his p
Paul Bettany Directs Wife Jennifer Connelly for Shelter: Photo 2959313 | Anthony Mackie, Jennifer Connelly, Paul Bettany...
Paul Bettany Directs Wife Jennifer Connelly for Shelter: Photo #2959313. Jennifer Connelly gives a coy smile while receiving a note from her director and husband Paul Bettany on the set of their latest film Shelter on Monday (September…
Brutally Honest: John Pauls story made me want to be a better person
If you thought that title meant Pope John Paul II, you wouldnt be faulted. Thats logical and in fact, Im sure theres truth to it. But Im talking here about John Paul Kilners story: Nothing can prepare you for seeing...
Excel 2016 Formulas and Functions (includes Content Update Program) av Paul McFedries (Heftet) | Tanum nettbokhandel
Excel 2016 Formulas and Functions (includes Content Update Program) (Heftet) av forfatter Paul McFedries. Pris kr 289. Se flere bøker fra Paul McFedries.
How old is Paul Sinha and what has The Chase star said about Parkinsons disease? - My Style News
In September 2020, Paul revealed that he wont let the disease dictate how he lives his life as he updates fans on Parkinsons battle.. Speaking on Loose Women, Paul said: By the time I got the diagnosis there was a sense of relief that it wasnt anything worse.. Im tired from time to time, but anyone thats quizzed with me in the last six months will tell you I am answering questions very very rapidly indeed.. The comedian added: I refuse to live in the future; I only want to live in the present and enjoy the present because I dont know what my future is. I dont know when I will start deteriorating. ...
Paul DArcy Racing - Things are fairly quiet runner-wise
PAUL DARCY is a Group 1, Classic winning trainer, based in Newmarket. Since starting out in 1998, Paul has achieved great success from a very small number of horses and has demonstrated his ability to achieve excellent results at the top level.
Rand Paul rejects rights based on your behavior | MSNBC
The senator doesnt recognize gay rights as a real issue because rights based on behavior lack legitimacy. Paul may not have thought this one through.
Settee of Stories: A sitdown with Paul Dickson - Visit Norwich
In Norwich, everyone has a story to tell. And well be sure to tell it. This week were joined by local tour guide, Paul Dickson.
Protocols and Video Articles Authored by Paul J. Cordo (Translated to Dutch)
Paul J. Cordo is the author of this article in the Journal of Visualized Experiments: Methode om Tone van axiale en proximale spier te meten
Paul Teri - Hicksville, NY - Counseling | Healthgrades.com
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Paul Erlich Quotes
Explore some of Paul Erlich best quotations and sayings on Quotes.net -- such as The first rule to tinkering is to save all the parts. and more...
Paul Van Gysegem - Square Talks (LP) - Soundohm
** 2021 Stock ** Dont judge a man by the size of his discography. Paul Van Gysegem can only be heard on a handful of releases, but he played a crucial role in the development and visibility of improv…
Mpls., St. Paul, Anoka-Hennepin, others to stay closed Tuesday - StarTribune.com
The Anoka-Hennepin district made the announcement early Monday afternoon, and was soon followed by Minneapolis, St. Paul and others.
Protocols and Video Articles Authored by Paul S. Wheatley (Translated to Dutch)
Paul S. Wheatley is the author of this article in the Journal of Visualized Experiments: Synthese van zeolieten met behulp van de ADOR (Assembly-Demontage-Organisatie-Montage) Route
Former Fed Chairman Paul Volcker Dies At 92 | WLRN
Volcker took the top job at the Federal Reserve in 1979, at a time when inflation was spiraling out of control. He is credited with taming it.
Paul Walsh - StarTribune.com
I want your news tips, especially in and near Minnesota. I write whats interesting and important, with interesting being my preference. Follow @walshpj
Paul Maplesden on HubPages
The aim of my writing is to illuminate and guide others to create positive change in the worldI do this through: - Being curious and sharing...
Articles :: LabOnline :: Page 7
Lab+Life Scientist magazine and LabOnline website providing The latest industry news, articles, Case studies, products, directory, Events
Playing Letters and Numbers: Ep 276: Paul Breen, Barry Cook (March 9, 2015; originally aired September 19, 2011)
Barry found a couple of very good words to take the early lead. Paul got some of the ground back in the first numbers round, but then Barry extended it again in round four. Paul managed to match Barry in the fifth round, and another good numbers result put him only a little behind. Then Barry faltered in the last letters round and Paul took the lead for the first time in the game. Neither contestant was able to make any headway on the last numbers round, and the conundrum also proved to be too difficult for them both. Paul wobbled home with the win, 31 to 26 ...
Paul Bley, Memorialized in NY Concert Thursday | Stereophile.com
Paul Bley is featured on The Montreal Tapes, with Charlie Haden and Paul Motian.I missed the chance to send off an R.I.P. to the jazz pianist Paul Bley, who died on January 3, at the age of 83, so Im catching up with this advance notice of a free memorial concert to be held this Thursday night, February 11, featuring piano solos by seven of his acolytes most notably Ethan Iverson and Frank Kimbrough, whom Ive lauded on this page many times.
Alumni US | Université Paul Sabatier (Toulouse III)
Graduates of Université Paul Sabatier (Toulouse III) - the names, photos, skill, job, location. Information on the Université Paul Sabatier (Toulouse III) - contacts, students, faculty, finances.
2008 Domaine Paul Autard Red Rhone Blend Châteauneuf-du-Pape Cuvée la Cote Ronde by Domaine Paul Autard (Rhône Blend)
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Xavier Paul Looks To Take Advantage of Ramirez Suspension | Bleacher Report
Xavier Paul is going to try to take advantage of Manny Ramirezs 50-game suspension.Paul was called up to take Mannys spot on the Dodgers 25-man roster after hitting .344 with a pair of home runs, eight stolen bases, and a ...
Whats Paul Walker Net Worth 2020 Revenue As Richest Actor
Paul Walker net worth is $25 Million. Also, he is a key part of Fast & Furious 2 with an income of $125 million. How Rich is Paul Walker? by networth 2020.
Paul McCartney - Drive My Car Lyrics
Paul McCartney Drive My Car Lyrics. Drive My Car lyrics performed by Paul McCartney: Asked a girl what she wanted to be She said baby, cant you see I wanna be famous, a star on the screen But you can do something in between
math--fast help please - search results
paul can type 60 words per minute and jen can type 80 words per minute. how dose puls typing speed compare to jen? 1.Paul can type 1/4 as fast as Jen. 2.Paul can type 1/3 as fast as Jen. 3.Paul can type 3/4 as fast as Jen. 4.Paul can type 1 1/3 times as fast as Jen. i think ... ...
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GI Drugs Flashcards by paul heggem | Brainscape
Study GI Drugs flashcards from paul heggem's class online, or in Brainscape's iPhone or Android app. ✓ Learn faster with spaced repetition.
9781402765728: Quit Smoking Today Without Gaining Weight - ZVAB - McKenna, Paul: 140276572X
Quit Smoking Today Without Gaining Weight von McKenna, Paul beim ZVAB.com - ISBN 10: 140276572X - ISBN 13: 9781402765728 - Sterling Pub - 2011 - Hardcover
Paul OGrady shares throwback to his The Bill stint | Entertainment Daily
Paul OGrady has shared a throwback to his days on The Bill that had his followers on Instagram comparing him to a stripper. Read more here.
Paul P. Liu, M.D., Ph.D.
Dr. Paul Liu is NHGRIs deputy scientific director and a senior investigator in NHGRIs Translational and Functional Genomics Branch.
Paul Seider | CaringBridge
Visit Paul Seiders CaringBridge website where youll find the latest updates and a place to share messages of love, hope & compassion.
Paul, Big, and Small by David Glen Robb
Paul, Big, and Small book. Read 50 reviews from the worlds largest community for readers. A trio of high school outcasts--Paul, Big, and Small--face the...
prof. dr. Paul Boon
Charlotte Germonpré (UGent) , Silke Proesmans (UGent) , Charlotte Bouckaert (UGent) , Latoya Stevens (UGent) , Mathieu Sprengers (UGent) , Kristl Vonck (UGent) , Evelien Carrette (UGent) , Wytse Wadman (UGent) , Paul Boon (UGent) , Robrecht Raedt (UGent) , et al. ...
Paul Kubes author profile - Rxivist
Research profile for Paul Kubes (University of Calgary), provided by Rxivist, the site that helps you find the most discussed biology preprints on the internet.
Ac-Cent-Tchu-Ate The Positive Lyrics - Paul McCartney
Lyrics to Ac-Cent-Tchu-Ate The Positive by Paul McCartney: Gather round me, everybody / Gather round me, while I preach some / Feel a
Song Of The Day 7/23/2013: Jerry Landis - The Lone Teen Ranger | Paul Pearson
Jerry Landis is Paul Simon, back before he got in touch with his Greenwich Village side. He actually recorded under several pseudonyms before folking himself into our lives. The Lone Teen Ranger, which doesnt make any narrative sense (but neither did Duke of Earl), got up to #99 on the American charts. It was released in 1962, five years after The Lone Ranger went off TV, so it wasnt exactly the timeliest of releases. Its cute to hear Simon do the doo-wop versicles at the beginning and throughout the track ...
Dr. Paul Weiden, MD - Juneau, AK - Oncology | Healthgrades.com
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Ron Pauls Farewell Address to Congress
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Paul Offit Lies About Jake Crosby; Tara Palmore Throws Him Out and NIH Covers it Up - AGE OF AUTISM
By Jake Crosby Like Seth Mnookin did earlier this month, Paul Offit blatantly lied about me while giving a lecture. The congressionally reprimanded millionaire vaccine industrialist told a room full of people I was a
Remembering Dr. Paul I. Terasaki
Dr. Paul I. Terasaki, HLA Pioneer, founder of One Lambda, Inc. and founder of the Terasaki Foundation, passed away the morning of January 25, 2016 at his home in Los Angeles.
Reformed Reasons: A Factious Man: Exegetical Treatment of Titus 3:10
By all accounts this schismatic man is engaging in the behavior condemned by Paul in v. 9. The heretic, in this context, is someone who is causing division within the church. Before you run out and begin to pronounce everyone a heretic, due care must be given to the particulars. First, what makes a heretic divisive is not simply his disagreement with Paul and Titus. It is the nature of his disagreement with them. Barnabas disagreed with Paul and he was not pronounced a heretic. Their disagreement was so sharp that they ceased working together. And yet Barnabas was never pronounced a heretic. Mere disagreement does not equal schismatic behavior. We should take care not to engage in malicious and slanderous practices by pronouncing those who have mere disagreements with us to be heretics or divisive. After all, Paul says in 3:2 that we are to malign no one. This word is the same word that is translated blaspheme and it means to speak about someone in a disrespectful way that demeans and ...
Paul Berntson | CaringBridge
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Sean Paul - Hey Baby lyrics | LyricsMode.com
Hey Baby lyrics by Sean Paul: Sexy ladies in the place / You know how we do it / [Hook] / Hey baby trinna find what you driving me crazy
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Shrink Rap: In Treatment: Jesse, Week 7
My therapist is always aware of issues that impact my sense of efficacy (since its rather low), and Paul acting this way seems to be strongly implying that Jesse cant get by without therapy with Paul, or that he cant have gained ANYTHING from their time together if things dont go in the future the way that PAUL wants them to go; it has nothing to do with anything Jesse does, at all, completely taking anything and everything away from him, that he participates in the therapy ...
Innovative modifications to processes can improve productivity, helping producers and manufacturers succeed in a challenging global environment. View full article › ...
Ecology Focus as James Joins BIGGA | News | About Us
Posted on Tuesday, 5th January 2016. BIGGA would like to welcome James Hutchinson to the team who has accepted the newly created role of Sustainability Executive.. James was previously Environmental Officer at St Andrews. Prior to that he was Ecology Manager at Fairhaven Golf Club in Lytham, Lancashire.. This new role will involve James working closely with the Golf Environment Organisation and other industry bodies to uncover and promote examples of good sustainability practice on golf courses among the BIGGA membership, and demonstrate our members commitment to sustainability.. James will also have an influence on our Learning & Development activity which will have an even more increased focus on this topical issue.. It is intended that BIGGA will offer a range of environmental and sustainability advisory services to its members and their golf clubs, as an acknowledged expert in his field with a successful track record in providing environmental plans James is an outstanding candidate to ...
Timeline of antibiotics
1911 - Arsphenamine a.k.a. Salvarsan 1912 - Neosalvarsan 1935 - Prontosil (an oral precursor to sulfanilamide), the first ...
Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led ... Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds and found to exhibit partially ... Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful ... Williams, KJ (1 August 2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
Williams, KJ (2009-08-01). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
List of German inventions and discoveries
Williams, K. J. (2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". J R Soc Med. 102 (8 ... First synthesis of arsphenamine, the first antibiotic, by Paul Ehrlich and Alfred Bertheim. In 1910 marketed by Hoechst under ...
Magic bullet (medicine)
With this new knowledge, Ehrlich tested Compound 606 (chemically arsphenamine) on a syphilis-infected rabbit. He did not ... Williams, K. (2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the Royal ...
Arsphenamine was first thought to be ineffective when it was tested by Ehrlich's former assistants, so their inadequate methods ... Hata returned to Japan and became the leading bacteriologist of his generation and continued his work testing arsphenamine ... When Hata injected compound 606, arsphenamine, into rabbits infected with syphilis, he found it to be effective against ... Williams, KJ (2009-08-01). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
Ehrlich then found that arsphenamine was found effective against syphilis spirochetes. The arsphenamines was then made ...
List of drugs by year of discovery
In 1907 Alfred Bertheim synthesized Arsphenamine, the first man-made antibiotic. In 1927 Erik Rotheim patented the first ...
His laboratory discovered arsphenamine (Salvarsan), the first effective medicinal treatment for syphilis, thereby initiating ... It focused on Salvarsan (arsphenamine, "compound 606"), his cure for syphilis. Since the Nazi government was opposed to this ... With the support of his assistant Sahachiro Hata Ehrlich discovered in 1909 that Compound 606, Arsphenamine, effectively ...
Dr. Ehrlich's Magic Bullet
This substance, first called "606", is now known as Arsphenamine or Salvarsan. The joy of discovery is short-lived, as 38 ...
Jay Frank Schamberg
At the time of the outbreak of World War I, the only effective treatments for syphilis were based on arsphenamine which was ... As early as March, 1916 the Research Institute was supplying arsphenamine to all 48 states and to the military. In Nov of 1917 ... Early in the war the Research Institute developed a process for the manufacture of arsphenamine. By early 1916, the supply of ...
1907 in Germany
Arsphenamine is first synthesised in 1907 in Paul Ehrlich's lab by Alfred Bertheim. Kaiser-Wilhelm-Brücke, a swing bridge is ...
The company Farbwerke Hoechst marketed arsphenamine as the drug Salvarsan, "the arsenic that saves". Its specificity of action ... Ehrlich and Bertheim's 606th arsenobenzene, synthesized in 1907, was arsphenamine, found ineffective against trypanosomes, but ...
The number 606 would become the slang name for the treatment with Salvarsan, the trade name for arsphenamine. Born: Ferenc ... Paul Ehrlich found the first successful treatment for syphilis, arsphenamine, on his 606th experiment. The compound, based on ...
... including arsphenamine (by Paul Ehrlich) and arsenic trioxide (by Thomas Fowler). Arsphenamine, as well as neosalvarsan, was ...
Poikiloderma vasculare atrophicans
Ingestion of substances containing arsenic, such as arsphenamine, has also been suggested as a least common cause. PVA can also ...
Tuskegee Syphilis Study
At that time, treatment included treatment with arsenic-based compounds such as arsphenamine (branded as the "606" formula). ...
The first modern chemotherapeutic agent was arsphenamine, an arsenic compound discovered in 1907 and used to treat syphilis. ...
The Abelin reaction is a qualitative reaction for demonstrating the presence of arsphenamine and neoarsphenamine in blood and ...
Traitement de la syphilis par le 606 : (précautions et doses), 1912 - Treatment of syphilis by arsphenamine: (doses and ... Treatment of syphilis by arsphenamine: action, dosage, technique. Le Chancre mou, symptomatologie, complications, diagnostic, ...
He was the first to use arsphenamine in the treatment of syphilis of the eye and the first to operate on retinal detachment by ... Joseph Igersheimer(1879-1965) was a German born ophthalmologist known for his work on arsphenamine for the treatment of ...
A representative leader was Joseph Igersheimer (1879-1965), best known for his discoveries with arsphenamine for the treatment ...
The first time a drug was systematically improved was with arsphenamine (Salvarsan). Numerous derivatives of the dangerously ...
制药产业 - 维基百科，自由的百科全书
The introduction of 'chemotherapy' using arsphenamine - the first magic bullet. Journal of the Royal Society of Medicine. 2009- ...
... arsphenamine) and neo-salvarson. Between 1914 and 1916 the workforce grew from 500 to 2,000 and sales from 15.7 million francs ...
This drug is now known as arsphenamine. The drug was used to treat syphilis in the first half of the 20th century. In 1908 ... "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the Royal Society of Medicine. 102 ...
The first antibiotic was arsphenamine (Salvarsan) discovered by Paul Ehrlich in 1908 after he observed that bacteria took up ...
The first effective treatment for syphilis was Arsphenamine, discovered by Sahachiro Hata in 1909, during a survey of hundreds ...
By 1910 Paul Ehrlich and his laboratory group began developing arsenic-based arsphenamine, (Salvarsan), as the first effective ...
"The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". J R Soc Med 102 (8): 343-8. PMC 2726818. PMID ...
Arsphenamine - Wikipedia
Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first ... Arsphenamine was first synthesized in 1907 in Paul Ehrlichs lab by Alfred Bertheim. The antisyphilitic activity of this ... Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that ... using arsphenamine - the first magic bullet". J R Soc Med. 102 (8): 343-8. doi:10.1258/jrsm.2009.09k036. PMC 2726818. PMID ...
Cureus | The Effect of Arsenic Preparations (Neoarsphenamine and Silver Arsphenamine) on the Protein Fractions of Blood Plasma...
Comment on Arsphenamine
Fatal post arsphenamine jaundice. | IMSEAR
Arsphenamine - Arsphenamine Exporter, Manufacturer, Distributor, Supplier, Trading Company, Vapi, India
Because of the popularity of beta-lactam drugs, certain bacteria have been able to develop counter-measures to traditional drug therapies. An enzyme called beta-lactamase is present in many different types of bacteria, which serves to break the beta lactam ring, which effectively nullifies the antibiotics effectiveness. An example such enzyme is the NDM-1 discovered in 2009.. As a response to bacterial resistance to beta-lactam drugs, there are drugs, such as Augmentin/CLA, that are designed to disable the beta-lactamase enzyme. Augmentin/CLA (FGP) is made of amoxicillin, a beta-lactam antibiotic, and clavulanic acid, a beta-lactamase inhibitor. The clavulanic acid is designed to overwhelm all beta-lactamase enzymes, bind irreversibly to them, and effectively serve as an antagonist so that the amoxicillin is not affected by the beta-lactamase enzymes.. Full article ▸. ...
The test uses several strains of the bacterium Salmonella typhimurium that carry mutations in genes involved in histidine synthesis i.e. it is a auxotrophic mutant, so that they require histidine for growth. The variable being tested is the mutagens ability to cause a reversion to growth on a histidine-free medium. The tester strains are specially constructed to have both frameshift and point mutations in the genes required to synthesize histidine, which allows for the detection of mutagens acting via different mechanisms. Some compounds are quite specific, causing reversions in just one or two strains. The tester strains also carry mutations in the genes responsible for lipopolysaccharide synthesis, making the cell wall of the bacteria more permeable, and in the excision repair system to make the test more sensitive. Rat liver extract is optionally added to simulate the effect of metabolism, as some compounds, like benzo[a]pyrene, are not mutagenic themselves but their metabolic ...
Inventor | Britannica
Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and Application | mBio
Arsphenamine (Salvarsan) was thus the first successful chemotherapeutic antibacterial agent (10).. Two decades later, while ... The introduction of "chemotherapy" using arsphenamine-the first magic bullet. J R Soc Med102:343-348. ... HISTORY OF CHEMOTHERAPEUTIC DEVELOPMENT FROM ARSPHENAMINE TO PAS. At the turn of the 20th century, chemotherapy was first ... the antisyphilis agent arsphenamine [Salvarsan]) to the first synthetic antimicrobial successfully used to treat tuberculosis ( ...
Timeline of antibiotics - Wikipedia
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Magic bullet (medicine) - Wikipedia
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The American Journal of Tropical Medicine and Hygiene | Volume s1-3, Issue 4
6. Neo-arsphenamine by rectum is efficacious. * 7. Colloidal quinine (Colobiases de Quinine-Dausse), in doses of 1 grain (0.065 ... 5. Neo-arsphenamine in concentrated solutions-as much as 0.9 gram in 2 cc.-fulfills all essential requirements of the higher ... 4. The arsphenamines promptly abort acute attacks in all forms of malaria, and are specifics in the tertian field. ...
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Antibiotic - Wikipedia
neoarsphenamine - Neosalvarsan Summary Report | CureHunter
Beattie J, Marshall J (1944) - The James Lind Library The James Lind Library
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Klinik der Lebersyphilis | Springer for Research & Development
This image is taken from United States Naval Medical Bulletin Vol. 13, Nos. 1-4, 1919
pharmaceutical industry | Britannica.com
Arsphenamine was marketed with the trade name of Salvarsan and was used to treat syphilis until the 1940s, when it was replaced ... The first of these was arsphenamine, which was developed in 1910 by the German medical scientist Paul Ehrlich for the treatment ... Arsphenamine was the 606th chemical studied by Ehrlich in his quest for an antisyphilitic drug. Its efficacy was first ... Arsphenamine was important not only because it was the first synthetic compound to kill a specific invading microorganism but ...
Table of Contents - February 25, 1938, 87 (2252) | Science
Interestingly enough, a revised structure of arsphenamine was published in 2005 (Lloyd et al., 2005). The story of arsphenamine ... The story of arsphenamine illustrates the value of both pharmacology and drug metabolism. Ehrlich established a system of ... Although arsphenamine had been the initial chemotherapeutic example of drug activation, the sulfanilamides had much greater ... The in vivo activity was later explained by Voegtlin and Smith when they determined that arsphenamine is actually a prodrug ...
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Antibiotici - Wikipedia
- Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis and African trypanosomiasis. (wikipedia.org)
- The arsphenamine, more known as Salvarsan and 606, is a drug used in the first half of the 20th century against syphilis and trypanosomiasis. (dd-database.org)
- The second was the development of antimicrobial chemotherapy from the first synthetic antibacterial drug (the antisyphilis agent arsphenamine [Salvarsan]) to the first synthetic antimicrobial successfully used to treat tuberculosis ( para -aminosalicylic acid [PAS]) ( 9 , 10 ). (asm.org)
- In 1907, Paul Ehrlich developed his "magic bullet" arsphenamine (Salvarsan) and thus began the modern antibiotic era. (jaoa.org)
- 5 and Paul Ehrlich's vision of a magic bullet to cure all infections was given credibility by the efficacy of Salvarsan (arsphenamine, an arsenic-containing compound) against syphilis. (mja.com.au)
- The introduction of this drug, arsphenamine (Salvarsan), and its chemical derivative neoarsphenamine (Neosalvarsan) in 1910 ushered in a complete transformation of syphilis therapy and the concept of chemotherapy. (cdc.gov)
- He did vast work on the problems of serology and immunity and is known preeminently for his discovery of salvarsan or "606," an arsenical compound later called arsphenamine, which was a cure for syphilis and the first effective chemotherapeutic agent against a microbial disease. (thefreedictionary.com)
Silver arsphenamine intravenously3
- 7 million persons used it on 17 days in decreasing tissue (eg, brain) concentrations of silver arsphenamine intravenously. (childbirthsolutions.com)
- When a thimerosal-containing vaccine is rmended for adults or 1 mg/kg (more toxic if excessive amounts of silver arsphenamine intravenously. (childbirthsolutions.com)
- Do not take painkillers such as phenelzine has been protected, the administration of silver arsphenamine intravenously. (biointegrity.org)
- citation needed] Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that causes syphilis. (wikipedia.org)
- With this new knowledge, Ehrlich tested Compound 606 (chemically arsphenamine ) on a syphilis-infected rabbit. (wikipedia.org)
- Before that, the only antimicrobials available were the arsenicals (arsphenamine and neosalvarsan), which were used to treat syphilis. (cdc.gov)
- Early neurosyphilis, characterized by meningitis, cranial nerve abnormalities, and cerebrospinal accidents, was first described in patients with syphilis who received inadequate courses of arsphenamine. (nih.gov)
- In that sense, the first modern chemotherapeutic agent was Paul Ehrlich's arsphenamine, an arsenic compound discovered in 1909 and used to treat syphilis. (phys.org)
- The use of antibiotics started in our modern history around the year 1911 with Arsphenamine which was found effective for syphilis. (canadiancattlemen.ca)
- The method of gland transfers was used to test the sterilizing effect of arsphenamine and neoarsphenamine on old infections in the rabbit. (curehunter.com)
Post arsphenamine jaundice2
- On the other hand, the antisyphilitic activity of arsphenamine, much used before the advent of modern antibiotics, is well documented. (dcnutrition.com)
- Arsphenamine was first synthesized in 1907 in Paul Ehrlich's lab by Alfred Bertheim. (wikipedia.org)
- In this vein, he went on to discover arsphenamine, an effective antisyphilis drug ( 1 ). (sciencemag.org)
- In the past, lichen spinulosus was reported to be associated with the administration of arsphenamine, thallium, gold, and diphtheria toxin. (medscape.com)
- One of these cases was apparently cured by a course of tartar emetic followed by a few small doses of arsphenamine. (ajtmh.org)
- The antibiotic era began with the development of arsphenamine by Paul Ehrlich and Sahachiro Hata. (medicine-opera.com)
- These lesions usually last 3-6 weeks and resolves, however, EN may recur frequently if the causative agent is not removed or treated. (dermatalk.com)
- There is a reference to the 'North Malaysia Leok Kooi Tong (北马六桂堂)' in http://en.wikipedia.org/wiki/Chinese_clan_association. (chinalanguage.com)
- If the retroperitoneal space by microbiologic testing for coeliac disease or test probability of heart failure can cause orthostatic hypotension, be unproductive if there is overflow of the electrosurgical unit output current is inhibited whereas humoral immunity and the placebo group over the right answer to this hypothesis, ehrlich introduced arsephenamine, the first randomized controlled trial. (cadasb.org)