An anti-infective agent that is used topically to treat skin infections and orally for urinary tract infections.
Antibacterial, potentially toxic, used to treat certain skin diseases.
A sulfathiazole antibacterial agent.
A methylsulfonyl analog of CHLORAMPHENICOL. It is an antibiotic and immunosuppressive agent.
Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.
A sulfanilamide that is used as an antibacterial agent.
Clavulanic acid and its salts and esters. The acid is a suicide inhibitor of bacterial beta-lactamase enzymes from Streptomyces clavuligerus. Administered alone, it has only weak antibacterial activity against most organisms, but given in combination with other beta-lactam antibiotics it prevents antibiotic inactivation by microbial lactamase.
Enzymes found in many bacteria which catalyze the hydrolysis of the amide bond in the beta-lactam ring. Well known antibiotics destroyed by these enzymes are penicillins and cephalosporins.
Four-membered cyclic AMIDES, best known for the PENICILLINS based on a bicyclo-thiazolidine, as well as the CEPHALOSPORINS based on a bicyclo-thiazine, and including monocyclic MONOBACTAMS. The BETA-LACTAMASES hydrolyze the beta lactam ring, accounting for BETA-LACTAM RESISTANCE of infective bacteria.
Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.
Substances that reduce the growth or reproduction of BACTERIA.
A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.
Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses).
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
Tests of chemical substances and physical agents for mutagenic potential. They include microbial, insect, mammalian cell, and whole animal tests.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed)
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
An essential amino acid that is required for the production of HISTAMINE.
A subgenus of Salmonella containing several medically important serotypes. The habitat for the majority of strains is warm-blooded animals.
Hard, amorphous, brittle, inorganic, usually transparent, polymerous silicate of basic oxides, usually potassium or sodium. It is used in the form of hard sheets, vessels, tubing, fibers, ceramics, beads, etc.
Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
Time period from 1901 through 2000 of the common era.
Time period from 1801 through 1900 of the common era.
The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.
A publication issued at stated, more or less regular, intervals.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
The profession of writing. Also the identity of the writer as the creator of a literary production.
Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.
Small antigenic determinants capable of eliciting an immune response only when coupled to a carrier. Haptens bind to antibodies but by themselves cannot elicit an antibody response.
Inorganic or organic compounds that contain arsenic.
The local lymph node assay (LLNA) is an alternative method for the identification of chemicals that have the ability to cause skin sensitization and allergic contact dermatitis. Endpoints have been established so fewer animals are required and less painful procedures are used.
A contact dermatitis due to allergic sensitization to various substances. These substances subsequently produce inflammatory reactions in the skin of those who have acquired hypersensitivity to them as a result of prior exposure.
Procedures, such as TISSUE CULTURE TECHNIQUES; mathematical models; etc., when used or advocated for use in place of the use of animals in research or diagnostic laboratories.
Substances intended to be applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance without affecting the body's structure or functions. Included in this definition are skin creams, lotions, perfumes, lipsticks, fingernail polishes, eye and facial makeup preparations, permanent waves, hair colors, toothpastes, and deodorants, as well as any material intended for use as a component of a cosmetic product. (U.S. Food & Drug Administration Center for Food Safety & Applied Nutrition Office of Cosmetics Fact Sheet (web page) Feb 1995)
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
An organochlorine insecticide that has been used as a pediculicide and a scabicide. It has been shown to cause cancer.
An acquired blood vessel disorder caused by severe deficiency of vitamin C (ASCORBIC ACID) in the diet leading to defective collagen formation in small blood vessels. Scurvy is characterized by bleeding in any tissue, weakness, ANEMIA, spongy gums, and a brawny induration of the muscles of the calves and legs.
The collective name for islands of the Pacific Ocean east of the Philippines, including the Mariana, PALAU, Caroline, Marshall, and Kiribati Islands. (From Webster's New Geographical Dictionary, 1988, p761 & Room, Brewer's Dictionary of Names, 1992, p350)
Time period from 1701 through 1800 of the common era.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
The study of natural phenomena by observation, measurement, and experimentation.
Libraries in which a major proportion of the resources are available in machine-readable format, rather than on paper or MICROFORM.
Books used in the study of a subject that contain a systematic presentation of the principles and vocabulary of a subject.
Sounds used in animal communication.
Disciplines concerned with the interrelationships of individuals in a social environment including social organizations and institutions. Includes Sociology and Anthropology.
Individual's rights to obtain and use information collected or generated by others.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.

Paul Ehrlich: pioneer of chemotherapy and cure by arsenic (1854-1915). (1/2)

Paul Ehrlich's experiments in staining techniques at the end of the nineteenth century resulted in many discoveries which help to form the basis of present research work. Ehrlich's chemotherapy research led to his formulating the arsenic compound, Salvarsan, which was used in the treatment of syphilis during the first half of this century until it was superseded by penicillin.  (+info)

Arsphenamine jaundice and the recognition of instrument-borne virus infection. (2/2)

Soon after its introduction in 1910, intravenous arsphenamine treatment for syphilis was found to be complicated by jaundice. The underlying cause, unsterile syringes and needles, was eventually recognised in the early 1940s, mainly through the efforts of British Army investigators. The infection most often transmitted was probably hepatitis B virus (HBV), but the high mortality in a few of the outbreaks of arsphenamine jaundice suggests that variants of HBV, or other hepatitis viruses, were sometimes involved. Fifty years later, at a time when there are estimated to be over three hundred million carriers of HBV in the world and probably at least as many hepatitis C virus carriers, and when the World Health Organisation estimates that there have been 17 million infections with human immunodeficiency virus, the lessons learnt around 1945 about the need to use sterile instruments and needles for all injections and venepunctures remain highly pertinent.  (+info)

TRIVENI INTERCHEM PVT. LTD. - Exporter, Manufacturer, Distributor, Supplier, Trading Company of Arsphenamine based in Vapi, India
The development of drugs for the treatment of infectious diseases was a major focus of early research and development efforts; in 1900 pneumonia, tuberculosis, and diarrhea were the three leading causes of death in the United States and mortality in the first year of life exceeded 10%.[12][13]. In 1911 arsphenamine, the first synthetic anti-infective drug, was developed by Paul Ehrlich and chemist Alfred Bertheim of the Institute of Experimental Therapy in Berlin. The drug was given the commercial name Salvarsan.[14] Ehrlich, noting both the general toxicity of arsenic and the selective absorption of certain dyes by bacteria, hypothesized that an arsenic-containing dye with similar selective absorption properties could be used to treat bacterial infections. Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and found to exhibit partially selective toxicity. Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that ...
This is the timeline of antimicrobial (anti-infective) therapy. The years show when a given drug was released onto the pharmaceutical market. This is not a timeline of the development of the antibiotics themselves. 1911 - Arsphenamine a.k.a. Salvarsan 1912 - Neosalvarsan 1935 - Prontosil (an oral precursor to sulfanilimide), the first sulfonamide 1936 - Sulfanilimide 1938 - Sulfapyridine (M&B 693) 1939 - sulfacetamide 1940 - sulfamethizole 1942 - benzylpenicillin, the first penicillin 1942 - gramicidin S, the first peptide antibiotic 1942 - sulfadimidine 1943 - sulfamerazine 1944 - streptomycin, the first aminoglycoside 1947 - sulfadiazine 1948 - chlortetracycline, the first tetracycline 1949 - chloramphenicol, the first amphenicol 1949 - neomycin 1950 - oxytetracycline 1950 - penicillin G procaine 1952 - erythromycin, the first macrolide 1954 - benzathine penicillin 1955 - spiramycin 1955 - tetracycline 1955 - thiamphenicol 1955 - vancomycin, the first glycopeptide 1956 - ...
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As my SHM presidency wraps up, it is a good time to reflect on the past year in hospital medicine. Dominated by COVID-19 preparedness, mitigation, and (now) rec
Other of Surgical Products - Sugar Scan Glucometer, Electric Needle Destroyer, Medical Air Bed and Hearing Aid Machine offered by Nikita Surgical, Nagpur, Maharashtra.
Paul Merson has urged Manchester United to be patient with Paul Pogba. https://www.thesportreview.com/wp-admin/upload.php The Red Devils star has
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Study more efficiently for Biologie Paul at Universität Tübingen ➤ Millions of flashcards & summaries ⭐ Get started for free with StudySmarter ✔
Explore St. Pauls words of encouragement and instruction for families. Through this study you will gain insight into what it...
애플의 기본 프로그램인 포토부스의 멋진 그래픽 필터 효과들을 사용해 본 경험이 있으세요? Paul Neave씨는 브라우저만으... (이 페이지는 태그 WebGL(으)로 필터링 되었습니다.)
臺灣幹細胞學會95年度工作報告. 中華民國95年1月1日至12月31日止. 一、九月舉行第一屆第二次年會及國際幹細研討會. 依據學會第一屆第三次的理監事會議後決議,95年度的年會暨研討會於九月一、二日在臺北醫學大學醫學綜合大樓舉行,並在會後延攬相關學者專家代表及學會理監事成立研討會籌備委員及工作小組。本年度大會,由幹細胞學會理事長暨中研院細生所游正博所長揭開序幕。而國際幹細胞學會理事長Paul ...
As most of you will be busy planning exciting reading activities, extreme reading photo competitions, and dazzling fiction-related fancy dress costumes for World Book Day tomorrow, I thought Id share a reading lesson to help alleviate the workload… This Reflective. ...
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Most of First Corinthians is Paul telling the people in the church there that they are not doing the right things by God, and he gives them advice on how to fix their actions ...
Interpretare si rationalitate - Paul Cornea - - Lucrarea constituie o explorare monografica a interpretarii, ca demers corectiv, explorator, mediator, explicat
2020 Daughters of St. Paul - Casa Generalizia - Via S. Giovanni Eudes, 25, 00163 Roma - tel: (06) 661.30.39 - email: [email protected] , Privacy ...
Paul M. B. Vitányi: Square Time is Optimal for Simulation of One Pushdown Store or One Queue by an Oblivious One-Head Tape Unit. Inf. Process. Lett. 21(2): 87-91 (1985 ...
2021 Daughters of St. Paul - Casa Generalizia - Via S. Giovanni Eudes, 25, 00163 Roma - tel: (06) 661.30.39 - email: [email protected] , Privacy ...
Paul Konerko cards, rookie cards and autographed memorabilia guide. Includes rookie card details, memorabilia highlights, shopping guide and more.
Brought to market in 2015, Essential Men by Paul Smith brings a fresh new platter to the table in the name of sophisticated casualness. Elegant and charming yet playful and approachable- Essential Men is made keeping in mind the common boy next door. While the woody essence instills a bold confident elegance in the pe
Paul McCartney, bassis The Beatles piawai bermain bass, tidak hanya kuat di lirik dan kualitas vokal. Perhatikan ketujuh lagu The Beatles berikut ini.
Icons made by Dave Gandy from www.flaticon.com is licensed by CC 3.0 BY. Icons made by Madebyoliver from www.flaticon.com is licensed by CC 3.0 BY. ...
Um unseren Newsletter zu abonnieren, trag bitte einfach Deine Email-Adresse unten ein. Du wirst dann eine Bestätigungsmail erhalten!. ...
I have a EVGA RTX 2080Ti Black. That is all of the GPU I need. You cannot even buy a RTX 3080 so where is one to get an RTX 4XXX?? People are buying ...
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Siapa sih yang tidak tahu coursera, banyak courses disana yang gratis maupun yang berbayar cukup mahal. Dan yang pasti kalau persoalan kualitas jangan ditanya lagi karena institusi/univeritas yang ngasih course adalah universitas/institusi top. Di masa Pandemi Covid19 ini coursera menawarkan beberapa courses yang tadinya berbayar menjadi gratis, udah gitu bisa dapat sertifikat. Saya malah prihatin…
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Drie namen, twee stijlen en n dubbelaar. Paul Elstak en Lunatic & Miss Hysteria zijn verantwoordelijk voor de nieuwste Hardcore Heroes mix cd. De tracklist is verassend en maakt ons in ieder geval nieuwsgierig om te luisteren wat deze iconen uit de scene neerzetten ...
There are four categories of Ron Paul voters. The first category is made up of true Paul supporters. They vote for Paul because they truly believe in his p
Hardcastle Paul - 19 Lyrics. Hardcastle Paul Miscellaneous 19 19 by Paul Hardcastle send any corrections to [email protected] In 1965 Vietnam seemed like just ano
Paul Bettany Directs Wife Jennifer Connelly for Shelter: Photo #2959313. Jennifer Connelly gives a coy smile while receiving a note from her director and husband Paul Bettany on the set of their latest film Shelter on Monday (September…
JB is the latest figure from Hollow Threat family. Its hand cast and painted by creator Paul Shih. Each JB figure stands 5.5 tall, with a limited run of 20 pieces available. If youre looking to pick one up, they will go up for sale - through Pauls shop - beginning at 1PM PST on Thursday October 28th 2010. Each JB will run $50.00 plus shipping.. ...
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PAUL DARCY is a Group 1, Classic winning trainer, based in Newmarket. Since starting out in 1998, Paul has achieved great success from a very small number of horses and has demonstrated his ability to achieve excellent results at the top level.
If you thought that title meant Pope John Paul II, you wouldnt be faulted. Thats logical and in fact, Im sure theres truth to it. But Im talking here about John Paul Kilners story: Nothing can prepare you for seeing...
In September 2020, Paul revealed that he wont let the disease dictate how he lives his life as he updates fans on Parkinsons battle.. Speaking on Loose Women, Paul said: By the time I got the diagnosis there was a sense of relief that it wasnt anything worse.. Im tired from time to time, but anyone thats quizzed with me in the last six months will tell you I am answering questions very very rapidly indeed.. The comedian added: I refuse to live in the future; I only want to live in the present and enjoy the present because I dont know what my future is. I dont know when I will start deteriorating. ...
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Paul J. Cordo is the author of this article in the Journal of Visualized Experiments: Methode om Tone van axiale en proximale spier te meten
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Someone help me understand what the issue is here. It sounds like Paul is correct here. By Faucis own definitions, it seems like they funded...
** 2021 Stock ** Dont judge a man by the size of his discography. Paul Van Gysegem can only be heard on a handful of releases, but he played a crucial role in the development and visibility of improv…
In Norwich, everyone has a story to tell. And well be sure to tell it. This week were joined by local tour guide, Paul Dickson.
The senator doesnt recognize gay rights as a real issue because rights based on behavior lack legitimacy. Paul may not have thought this one through.
Paul S. Wheatley is the author of this article in the Journal of Visualized Experiments: Synthese van zeolieten met behulp van de ADOR (Assembly-Demontage-Organisatie-Montage) Route
The Anoka-Hennepin district made the announcement early Monday afternoon, and was soon followed by Minneapolis, St. Paul and others.
Explore some of Paul Erlich best quotations and sayings on Quotes.net -- such as The first rule to tinkering is to save all the parts. and more...
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The aim of my writing is to illuminate and guide others to create positive change in the worldI do this through: - Being curious and sharing...
Volcker took the top job at the Federal Reserve in 1979, at a time when inflation was spiraling out of control. He is credited with taming it.
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A recent conversation with Paul Pridham (author of the Sword of Fargoal remake) caused me to consider the phenomenon of abandonware further. Some of Pauls
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That is what the Evening Standards Paul Waugh is reporting. I certainly hope so. Caroline Spelman might never have been my choice for CCHQ but as said at the time shes a woman of integrity and I hope she is...
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1911 - Arsphenamine a.k.a. Salvarsan 1912 - Neosalvarsan 1935 - Prontosil (an oral precursor to sulfanilamide), the first ...
Arsphenamine proved to be the first effective treatment for syphilis, a disease which prior to that time was incurable and led ... Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds and found to exhibit partially ... Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful ... Williams, KJ (1 August 2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
Williams, KJ (2009-08-01). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
Williams, K. J. (2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". J R Soc Med. 102 (8 ... First synthesis of arsphenamine, the first antibiotic, by Paul Ehrlich and Alfred Bertheim. In 1910 marketed by Hoechst under ...
With this new knowledge, Ehrlich tested Compound 606 (chemically arsphenamine) on a syphilis-infected rabbit. He did not ... Williams, K. (2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the Royal ...
Arsphenamine was first thought to be ineffective when it was tested by Ehrlich's former assistants, so their inadequate methods ... Hata returned to Japan and became the leading bacteriologist of his generation and continued his work testing arsphenamine ... When Hata injected compound 606, arsphenamine, into rabbits infected with syphilis, he found it to be effective against ... Williams, KJ (2009-08-01). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
Ehrlich then found that arsphenamine was found effective against syphilis spirochetes. The arsphenamines was then made ...
In 1907 Alfred Bertheim synthesized Arsphenamine, the first man-made antibiotic. In 1927 Erik Rotheim patented the first ...
His laboratory discovered arsphenamine (Salvarsan), the first effective medicinal treatment for syphilis, thereby initiating ... It focused on Salvarsan (arsphenamine, "compound 606"), his cure for syphilis. Since the Nazi government was opposed to this ... With the support of his assistant Sahachiro Hata Ehrlich discovered in 1909 that Compound 606, Arsphenamine, effectively ...
This substance, first called "606", is now known as Arsphenamine or Salvarsan. The joy of discovery is short-lived, as 38 ...
At the time of the outbreak of World War I, the only effective treatments for syphilis were based on arsphenamine which was ... As early as March, 1916 the Research Institute was supplying arsphenamine to all 48 states and to the military. In Nov of 1917 ... Early in the war the Research Institute developed a process for the manufacture of arsphenamine. By early 1916, the supply of ...
Arsphenamine is first synthesised in 1907 in Paul Ehrlich's lab by Alfred Bertheim. Kaiser-Wilhelm-Brücke, a swing bridge is ...
The company Farbwerke Hoechst marketed arsphenamine as the drug Salvarsan, "the arsenic that saves". Its specificity of action ... Ehrlich and Bertheim's 606th arsenobenzene, synthesized in 1907, was arsphenamine, found ineffective against trypanosomes, but ...
The number 606 would become the slang name for the treatment with Salvarsan, the trade name for arsphenamine. Born: Ferenc ... Paul Ehrlich found the first successful treatment for syphilis, arsphenamine, on his 606th experiment. The compound, based on ...
... including arsphenamine (by Paul Ehrlich) and arsenic trioxide (by Thomas Fowler). Arsphenamine, as well as neosalvarsan, was ...
Ingestion of substances containing arsenic, such as arsphenamine, has also been suggested as a least common cause. PVA can also ...
At that time, treatment included treatment with arsenic-based compounds such as arsphenamine (branded as the "606" formula). ...
The first modern chemotherapeutic agent was arsphenamine, an arsenic compound discovered in 1907 and used to treat syphilis. ...
The Abelin reaction is a qualitative reaction for demonstrating the presence of arsphenamine and neoarsphenamine in blood and ...
Traitement de la syphilis par le 606 : (précautions et doses), 1912 - Treatment of syphilis by arsphenamine: (doses and ... Treatment of syphilis by arsphenamine: action, dosage, technique. Le Chancre mou, symptomatologie, complications, diagnostic, ...
He was the first to use arsphenamine in the treatment of syphilis of the eye and the first to operate on retinal detachment by ... Joseph Igersheimer(1879-1965) was a German born ophthalmologist known for his work on arsphenamine for the treatment of ...
A representative leader was Joseph Igersheimer (1879-1965), best known for his discoveries with arsphenamine for the treatment ...
... arsphenamine) and neo-salvarson. Between 1914 and 1916 the workforce grew from 500 to 2,000 and sales from 15.7 million francs ...
The first antibiotic was arsphenamine (Salvarsan) discovered by Paul Ehrlich in 1908 after he observed that bacteria took up ...
The first effective treatment for syphilis was Arsphenamine, discovered by Sahachiro Hata in 1909, during a survey of hundreds ...
By 1910 Paul Ehrlich and his laboratory group began developing arsenic-based arsphenamine, (Salvarsan), as the first effective ...
... chemotherapy shown by Paul Ehrlich and others was worth pursuing with more research-and that early wins such as arsphenamine ...
Arsphenamine, the first modern chemotherapeutic agent 1909 - Fritz Haber: Haber Process for industrial production of ammonia ...
The drug "606" or "compound 606", which became known as arsphenamine Roland TR-606 Drum Machine 606 (radio show), the BBC Radio ...
Hoechst AG market Arsphenamine under the trade name daggga, the first organic antisyphilitic, its properties having been ...
Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first ... Arsphenamine was first synthesized in 1907 in Paul Ehrlichs lab by Alfred Bertheim. The antisyphilitic activity of this ... Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that ... using arsphenamine - the first magic bullet". J R Soc Med. 102 (8): 343-8. doi:10.1258/jrsm.2009.09k036. PMC 2726818. PMID ...
The Effect of Arsenic Preparations (Neoarsphenamine and Silver Arsphenamine) on the Protein Fractions of Blood Plasma in ...
Arsphenamine. 03.21.2013 Author: admin Category: Antibiotics 0 Comment » The arsphenamine, more known as Salvarsan and 606, is ...
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Arsphenamine / Humans / Male / Cholestasis / Adult Language: ... Full text: Available Index: IMSEAR (South-East Asia) Main subject: Arsphenamine / Humans / Male / Cholestasis / Adult Language: ...
Exporter, Manufacturer, Distributor, Supplier, Trading Company of Arsphenamine based in Vapi, India ...
1911 - Arsphenamine a.k.a. Salvarsan 1912 - Neosalvarsan 1935 - Prontosil (an oral precursor to sulfanilamide), the first ...
Because of the popularity of beta-lactam drugs, certain bacteria have been able to develop counter-measures to traditional drug therapies. An enzyme called beta-lactamase is present in many different types of bacteria, which serves to break the beta lactam ring, which effectively nullifies the antibiotics effectiveness. An example such enzyme is the NDM-1 discovered in 2009.. As a response to bacterial resistance to beta-lactam drugs, there are drugs, such as Augmentin/CLA, that are designed to disable the beta-lactamase enzyme. Augmentin/CLA (FGP) is made of amoxicillin, a beta-lactam antibiotic, and clavulanic acid, a beta-lactamase inhibitor. The clavulanic acid is designed to overwhelm all beta-lactamase enzymes, bind irreversibly to them, and effectively serve as an antagonist so that the amoxicillin is not affected by the beta-lactamase enzymes.. Full article ▸. ...
The test uses several strains of the bacterium Salmonella typhimurium that carry mutations in genes involved in histidine synthesis i.e. it is a auxotrophic mutant, so that they require histidine for growth. The variable being tested is the mutagens ability to cause a reversion to growth on a histidine-free medium. The tester strains are specially constructed to have both frameshift and point mutations in the genes required to synthesize histidine, which allows for the detection of mutagens acting via different mechanisms. Some compounds are quite specific, causing reversions in just one or two strains.[3] The tester strains also carry mutations in the genes responsible for lipopolysaccharide synthesis, making the cell wall of the bacteria more permeable,[4] and in the excision repair system to make the test more sensitive.[5] Rat liver extract is optionally added to simulate the effect of metabolism, as some compounds, like benzo[a]pyrene, are not mutagenic themselves but their metabolic ...
arsphenamine anti-syphilis drug. 1910. Isaac Newton Lewis. American. Lewis machine gun. 1911. ...
Arsphenamine (Salvarsan) was thus the first successful chemotherapeutic antibacterial agent (10).. Two decades later, while ... The introduction of "chemotherapy" using arsphenamine-the first magic bullet. J R Soc Med102:343-348. ... HISTORY OF CHEMOTHERAPEUTIC DEVELOPMENT FROM ARSPHENAMINE TO PAS. At the turn of the 20th century, chemotherapy was first ... the antisyphilis agent arsphenamine [Salvarsan]) to the first synthetic antimicrobial successfully used to treat tuberculosis ( ...
Arsphenamine was important not only because it was the first synthetic compound to kill a specific invading microorganism but ... history of medicine: Ehrlich and arsphenamine. Their success inaugurated the chemotherapeutic era, which was to revolutionize ...
1911 - Arsphenamine a.k.a. Salvarsan 1912 - Neosalvarsan 1935 - Prontosil (an oral precursor to sulfanilamide), the first ...
With this new knowledge, Ehrlich tested Compound 606 (chemically arsphenamine) on a syphilis-infected rabbit. He did not ... "The introduction of chemotherapy using arsphenamine - the first magic bullet". Journal of the Royal Society of Medicine. 102 ...
The first time a drug was systematically improved was with arsphenamine (Salvarsan). Numerous derivatives of the dangerously ...
6. Neo-arsphenamine by rectum is efficacious. * 7. Colloidal quinine (Colobiases de Quinine-Dausse), in doses of 1 grain (0.065 ... 5. Neo-arsphenamine in concentrated solutions-as much as 0.9 gram in 2 cc.-fulfills all essential requirements of the higher ... 4. The arsphenamines promptly abort acute attacks in all forms of malaria, and are specifics in the tertian field. ...
1907 - Arsphenamine, first modern medicine ,, No, any drug that has side effects is poisonous and not healthful. See 1861.. ...
His lab also discovered arsphenamine (Salvarsan), the first effective treatment for syphilis. These discoveries were the start ...
The introduction of chemotherapy using arsphenamine - the first magic bullet. Journal of the Royal Society of Medicine. 2009- ...
arsphenamine Hazard to Others. Posts: 236 Registered: 12-8-2010 Location: I smell horses, Maryland, USA Member Is Offline Mood: ...
arsphenamine Hazard to Others. Posts: 236 Registered: 12-8-2010 Location: I smell horses, Maryland, USA Member Is Offline Mood: ...
This drug is now known as arsphenamine.[101] The drug was used to treat syphilis in the first half of the 20th century. In 1908 ... "The introduction of chemotherapy using arsphenamine - the first magic bullet". Journal of the Royal Society of Medicine. 102 ...
03/31/1923 - "4. The method of gland transfers was used to test the sterilizing effect of arsphenamine and neoarsphenamine on ...
The value of sulphur-containing amino-acids and casein digest in the prevention of post-arsphenamine jaundice. BMJ 2: 651-655. ... The value of sulphur-containing amino-acids and casein digest in the prevention of post-arsphenamine jaundice. BMJ 2: 651-655. ...
The value of sulphur-containing amino-acids and casein digest in the prevention of post-arsphenamine jaundice. BMJ 2: 651-655. ...
Oliver: Arsphenamine hepatitis, maculopap. and syphilid. Arch. of Dermat. 14, Nr 4 (1926).Google Scholar ... Dixen, Campbell and Hanna: The control of arsphenamine treatem. by liver function tets. Ref. Zbl. Hautkrkh. 23, 836 (1927). ...
p class=MsoNormal style=margin-bottom:.0001pt;line-height:normal;,Death following arsphenamine. Page.,/p,. ,p class= ...
ON THE SPIROCHETICIDAL ACTION OF THE ARSPHENAMINES ON SPIROCHETA PALLIDA IN VITRO ...
Interestingly enough, a revised structure of arsphenamine was published in 2005 (Lloyd et al., 2005). The story of arsphenamine ... The story of arsphenamine illustrates the value of both pharmacology and drug metabolism. Ehrlich established a system of ... Although arsphenamine had been the initial chemotherapeutic example of drug activation, the sulfanilamides had much greater ... The in vivo activity was later explained by Voegtlin and Smith when they determined that arsphenamine is actually a prodrug ...
Examples are quinine (q. v.), used against malaria; arsphenamine, used against syphilis; the sulfa drugs (q.v.) , used against ...
"The introduction of chemotherapy using arsphenamine - the first magic bullet". J R Soc Med 102 (8): 343-8. PMC 2726818. PMID ...
  • Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis and African trypanosomiasis. (wikipedia.org)
  • The arsphenamine, more known as Salvarsan and 606, is a drug used in the first half of the 20th century against syphilis and trypanosomiasis. (dd-database.org)
  • The second was the development of antimicrobial chemotherapy from the first synthetic antibacterial drug (the antisyphilis agent arsphenamine [Salvarsan]) to the first synthetic antimicrobial successfully used to treat tuberculosis ( para -aminosalicylic acid [PAS]) ( 9 , 10 ). (asm.org)
  • In 1907, Paul Ehrlich developed his "magic bullet" arsphenamine (Salvarsan) and thus began the modern antibiotic era. (jaoa.org)
  • 5 and Paul Ehrlich's vision of a magic bullet to cure all infections was given credibility by the efficacy of Salvarsan (arsphenamine, an arsenic-containing compound) against syphilis. (mja.com.au)
  • He did vast work on the problems of serology and immunity and is known preeminently for his discovery of salvarsan or "606," an arsenical compound later called arsphenamine, which was a cure for syphilis and the first effective chemotherapeutic agent against a microbial disease. (thefreedictionary.com)
  • The arsenic preparation known as "606," Salvarsan, or arsphenamine is historically important as the first drug to kill the germs of syphilis ( see Paul Ehrlich ). (britannica.com)
  • 7 million persons used it on 17 days in decreasing tissue (eg, brain) concentrations of silver arsphenamine intravenously. (childbirthsolutions.com)
  • When a thimerosal-containing vaccine is rmended for adults or 1 mg/kg (more toxic if excessive amounts of silver arsphenamine intravenously. (childbirthsolutions.com)
  • Do not take painkillers such as phenelzine has been protected, the administration of silver arsphenamine intravenously. (biointegrity.org)
  • citation needed] Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that causes syphilis. (wikipedia.org)
  • With this new knowledge, Ehrlich tested Compound 606 (chemically arsphenamine ) on a syphilis-infected rabbit. (wikipedia.org)
  • Before that, the only antimicrobials available were the arsenicals (arsphenamine and neosalvarsan), which were used to treat syphilis. (cdc.gov)
  • Early neurosyphilis, characterized by meningitis, cranial nerve abnormalities, and cerebrospinal accidents, was first described in patients with syphilis who received inadequate courses of arsphenamine. (nih.gov)
  • In that sense, the first modern chemotherapeutic agent was Paul Ehrlich's arsphenamine, an arsenic compound discovered in 1909 and used to treat syphilis. (phys.org)
  • For example, there's the "606 Dance" , a tune composed in celebration of a new treatment for syphilis called arsphenamine or "Compound 606. (withgoodreasonradio.org)
  • The use of antibiotics started in our modern history around the year 1911 with Arsphenamine which was found effective for syphilis. (canadiancattlemen.ca)
  • Fatal post arsphenamine jaundice. (bvsalud.org)
  • The value of sulphur-containing amino-acids and casein digest in the prevention of post-arsphenamine jaundice. (jameslindlibrary.org)
  • The method of gland transfers was used to test the sterilizing effect of arsphenamine and neoarsphenamine on old infections in the rabbit. (curehunter.com)
  • On the other hand, the antisyphilitic activity of arsphenamine, much used before the advent of modern antibiotics, is well documented. (dcnutrition.com)
  • Arsphenamine was first synthesized in 1907 in Paul Ehrlich's lab by Alfred Bertheim. (wikipedia.org)
  • In this vein, he went on to discover arsphenamine, an effective antisyphilis drug ( 1 ). (sciencemag.org)
  • In the past, lichen spinulosus was reported to be associated with the administration of arsphenamine, thallium, gold, and diphtheria toxin. (medscape.com)
  • One of these cases was apparently cured by a course of tartar emetic followed by a few small doses of arsphenamine. (ajtmh.org)
  • The antibiotic era began with the development of arsphenamine by Paul Ehrlich and Sahachiro Hata. (medicine-opera.com)
  • These lesions usually last 3-6 weeks and resolves, however, EN may recur frequently if the causative agent is not removed or treated. (dermatalk.com)
  • There is a reference to the 'North Malaysia Leok Kooi Tong (北马六桂堂)' in http://en.wikipedia.org/wiki/Chinese_clan_association. (chinalanguage.com)
  • If the retroperitoneal space by microbiologic testing for coeliac disease or test probability of heart failure can cause orthostatic hypotension, be unproductive if there is overflow of the electrosurgical unit output current is inhibited whereas humoral immunity and the placebo group over the right answer to this hypothesis, ehrlich introduced arsephenamine, the first randomized controlled trial. (cadasb.org)