Arsphenamine, also known as Salvarsan, is an arsenic-based medication that was historically used to treat syphilis and other spirochetal infections, but has largely been replaced by modern antibiotics due to its toxicity and difficult administration.

Paul Ehrlich: pioneer of chemotherapy and cure by arsenic (1854-1915). (1/2)

Paul Ehrlich's experiments in staining techniques at the end of the nineteenth century resulted in many discoveries which help to form the basis of present research work. Ehrlich's chemotherapy research led to his formulating the arsenic compound, Salvarsan, which was used in the treatment of syphilis during the first half of this century until it was superseded by penicillin.  (+info)

Arsphenamine jaundice and the recognition of instrument-borne virus infection. (2/2)

Soon after its introduction in 1910, intravenous arsphenamine treatment for syphilis was found to be complicated by jaundice. The underlying cause, unsterile syringes and needles, was eventually recognised in the early 1940s, mainly through the efforts of British Army investigators. The infection most often transmitted was probably hepatitis B virus (HBV), but the high mortality in a few of the outbreaks of arsphenamine jaundice suggests that variants of HBV, or other hepatitis viruses, were sometimes involved. Fifty years later, at a time when there are estimated to be over three hundred million carriers of HBV in the world and probably at least as many hepatitis C virus carriers, and when the World Health Organisation estimates that there have been 17 million infections with human immunodeficiency virus, the lessons learnt around 1945 about the need to use sterile instruments and needles for all injections and venepunctures remain highly pertinent.  (+info)

Arsphenamine is an antimicrobial drug, specifically a type of organic arsenical compound. It is also known as Salvarsan or Compound 305. Arsphenamine was the first effective treatment for syphilis, discovered by Paul Ehrlich in 1909. The drug works by binding to bacterial enzymes and interfering with their metabolism, leading to the death of the bacteria. However, due to its toxicity and the availability of safer and more effective antibiotics, arsphenamine is rarely used today.

... , also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first ... Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that ... Arsphenamine was originally called "606" because it was the sixth in the sixth group of compounds synthesized for testing; it ... Arsphenamine was first synthesized in 1907 in Paul Ehrlich's lab by Alfred Bertheim. The antisyphilitic activity of this ...
1911 - Arsphenamine a.k.a. Salvarsan 1912 - Neosalvarsan 1935 - Prontosil (an oral precursor to sulfanilamide), the first ...
Arsphenamine was prepared as part of a campaign to synthesize a series of such compounds, and was found to exhibit partially ... Arsphenamine proved to be the first effective treatment for syphilis, a disease untl then had been incurable and led inexorably ... Compared to arsphenamine, the sulfonamides had a broader spectrum of activity and were far less toxic, rendering them useful ... Williams, KJ (1 August 2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". J. R. Soc. Med ...
Williams, KJ (2009-08-01). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
The Hoechst company began to market the compound toward the end of 1910 under the name Salvarsan, now known as arsphenamine. ... Williams KJ (August 2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ... now called arsphenamine. This heralded the era of antibacterial treatment that was begun with the discovery of a series of ...
Williams, K. J. (2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". J R Soc Med. 102 (8 ... First synthesis of arsphenamine, the first antibiotic, by Paul Ehrlich and Alfred Bertheim. In 1910 marketed by Hoechst under ...
Ehrlich created the concept of magic bullet based on the development of arsphenamine and introduced the English phrase "magic ... With this new knowledge, Ehrlich tested Compound 606 (chemically arsphenamine) on a syphilis-infected rabbit. He did not ... Williams, K. (2009). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the Royal ...
Arsphenamine was first thought to be ineffective when it was tested by Ehrlich's former assistants, so their inadequate methods ... Hata returned to Japan and became the leading bacteriologist of his generation and continued his work testing arsphenamine ... When Hata injected compound 606, arsphenamine, into rabbits infected with syphilis, he found it to be effective against ... Williams, KJ (2009-08-01). "The introduction of 'chemotherapy' using arsphenamine - the first magic bullet". Journal of the ...
Ehrlich then found that arsphenamine was found effective against syphilis spirochetes. The arsphenamines was then made ...
In 1907 Alfred Bertheim synthesized Arsphenamine, the first man-made antibiotic. In 1927 Erik Rotheim patented the first ...
His laboratory discovered arsphenamine (Salvarsan), the first effective medicinal treatment for syphilis, thereby initiating ... It focused on Salvarsan (arsphenamine, "compound 606"), his cure for syphilis. Since the Nazi government was opposed to this ... With the support of his assistant Sahachiro Hata Ehrlich discovered in 1909 that Compound 606, Arsphenamine, effectively ...
This substance, first called "606", then Salvarsan, is now known as Arsphenamine. The joy of discovery is short-lived, as 38 ...
At the time of the outbreak of World War I, the only effective treatments for syphilis were based on arsphenamine which was ... As early as March, 1916 the Research Institute was supplying arsphenamine to all 48 states and to the military. In Nov of 1917 ... Early in the war the Research Institute developed a process for the manufacture of arsphenamine. By early 1916, the supply of ...
Arsphenamine is first synthesised in 1907 in Paul Ehrlich's lab by Alfred Bertheim. Kaiser-Wilhelm-Brücke, a swing bridge is ...
In 1936, a public health campaign began to prescribe arsphenamine to treat syphilis. Between 1945 and 1955 penicillin was used ...
The company Farbwerke Hoechst marketed arsphenamine as the drug Salvarsan, "the arsenic that saves". Its specificity of action ... Ehrlich and Bertheim's 606th arsenobenzene, synthesized in 1907, was arsphenamine, found ineffective against trypanosomes, but ...
The number 606 would become the slang name for the treatment with Salvarsan, the trade name for arsphenamine. Abbot Augustus ... Paul Ehrlich found the first successful treatment for syphilis, arsphenamine, on his 606th experiment. The compound, based on ...
At that time, treatment included arsenic-based compounds such as arsphenamine (branded as the "606" formula). Initially, ...
... including arsphenamine (by Paul Ehrlich) and arsenic trioxide (by Thomas Fowler). Arsphenamine, as well as neosalvarsan, was ...
Arsphenamine). After the move to Mukteswar the main work was the search for a rinderpest vaccine. The work began in 1897. The ...
Ingestion of substances containing arsenic, such as arsphenamine, has also been suggested as a least common cause. PVA can also ...
The first modern chemotherapeutic agent was arsphenamine, an arsenic compound discovered in 1907 and used to treat syphilis. ...
The Abelin reaction is a qualitative reaction for demonstrating the presence of arsphenamine and neoarsphenamine in blood and ...
Traitement de la syphilis par le 606 : (précautions et doses), 1912 - Treatment of syphilis by arsphenamine: (doses and ... Treatment of syphilis by arsphenamine: action, dosage, technique. Le Chancre mou, symptomatologie, complications, diagnostic, ...
He was the first to use arsphenamine in the treatment of syphilis of the eye and the first to operate on retinal detachment by ... Joseph Igersheimer(1879-1965) was a German born ophthalmologist known for his work on arsphenamine for the treatment of ...
A representative leader was Joseph Igersheimer (1879-1965), best known for his discoveries with arsphenamine for the treatment ...
When the study started, arsphenamine (Salvarsan) and Neosalvarsan were the only available treatments for syphilis, and both ...
He summoned a group of experts to analyse and produce arsphenamine, known as "606", a drug formerly sourced from Bayer in ...
... arsphenamine) and neo-salvarsan. Between 1914 and 1916 the workforce grew from 500 to 2,000 and sales from 15.7 million francs ...
The first antibiotic was arsphenamine (Salvarsan) discovered by Paul Ehrlich in 1908 after he observed that bacteria took up ...
Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first ... Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that ... Arsphenamine was originally called "606" because it was the sixth in the sixth group of compounds synthesized for testing; it ... Arsphenamine was first synthesized in 1907 in Paul Ehrlichs lab by Alfred Bertheim. The antisyphilitic activity of this ...
AN EXPERIMENTAL INVESTIGATION OF THE CAUSE OF EARLY DEATH FROM ARSPHENAMINE, AND OF CERTAIN OTHER FEATURES OF THE ... AN EXPERIMENTAL INVESTIGATION OF THE CAUSE OF EARLY DEATH FROM ARSPHENAMINE, AND OF CERTAIN OTHER FEATURES OF THE ... AN EXPERIMENTAL INVESTIGATION OF THE CAUSE OF EARLY DEATH FROM ARSPHENAMINE, AND OF CERTAIN OTHER FEATURES OF THE ... AN EXPERIMENTAL INVESTIGATION OF THE CAUSE OF EARLY DEATH FROM ARSPHENAMINE, AND OF CERTAIN OTHER FEATURES OF THE ...
Arsphenamine was for many years the standard treatment for syphilis. Melarsoprol is an organoarsenic compound used to treat ...
Arsphenamine, also known as salvarsan, discovered in 1907 by Paul Ehrlich.. Synthetic antibiotic chemotherapy as a science and ... now known as arsphenamine.[129] The drug was used to treat syphilis in the first half of the 20th century. In 1908, Ehrlich ... "The introduction of chemotherapy using arsphenamine - the first magic bullet". Journal of the Royal Society of Medicine. 102 ...
Before that, the only antimicrobials available were the arsenicals (arsphenamine and neosalvarsan), which were used to treat ...
To his surprise the amount corresponded to 8 g of silver arsphenamine. He had no idea how he had accumulated so much silver in ... 19) Silver arsphenamine was used to treat neurosyphilis. Some doctors thought it an effective treatment, others didnt. (20) ... 7)(According to Hill and Pillsbury six grams of silver arsphenamine are equivalent to 0.9 grams of metallic silver.) (8) In ... In one instance 4 grams of injected silver arsphenamine produced argyria. In another it took 20 grams. ( ...
In the early 1930s treatment consisted of mercury and two arsenic compounds called arsphenamine and neoarsphenamine, known also ...
In 1909, Paul Ehrlich discovered arsphenamine (Salvarsan), an arsenic compound that kills Treponema palladium, the bacterium ...
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... now known as arsphenamine.[105] The drug was used to treat syphilis in the first half of the 20th century. In 1908, Ehrlich ... "The introduction of chemotherapy using arsphenamine - the first magic bullet". Journal of the Royal Society of Medicine. 102 ...
The arsphenamines was then made available in, know as salvarsan. In many cities where the public transit system is shoddy, only ...
Arsphenamine for example, endoplasmic reticulum via tnf-α receptors, which is the slavic nations childrens risk. Curiously, ...
Humans had no use for arsphenamine and penicillin after only a couple of years of their development. Apparently, the ...
... and arsphenamine. Arsenic is believed to exert its toxicity by combining with certain enzymes, thereby interfering with ...
The first modern chemotherapeutic agent was arsphenamine, an arsenic compound discovered in 1907 and used to treat syphilis. ...
... arsphenamine, and insect venoms. In patients with lead colic, leukocyte counts as high as 20 X 109/L may be seen. ...
The total dose of silver needed to cause argyria with silver arsphenamine was approximately 6 g, or 0.9 g of metallic silver ...
... after approximately four thousand injections of the arsphenamines. Its exceptional severity and unusual character, coupled with ...
While arsphenamine was energetic in opposition to syphilis only, sulfamidochrysoidine was the ?rst drug with activity against a ...
The discovery of arsphenamine, first synthesised by Alfred Bertheim and Paul Ehrlich in 1907, used to treat syphilis added to ...
  • Arsphenamine, also known as Salvarsan or compound 606, is a drug that was introduced at the beginning of the 1910s as the first effective treatment for syphilis, relapsing fever, and African trypanosomiasis. (wikipedia.org)
  • In 1909, Paul Ehrlich discovered arsphenamine (Salvarsan), an arsenic compound that kills Treponema palladium , the bacterium causing the sexually transmitted disease, syphilis. (mo.gov)
  • In 1910, the German bacteriologist Paul Ehrlich made a groundbreaking discovery and patented arsphenamine , a chemical compound derived from arsenic that proved effective against syphilis and was marketed for two decades under the trade name 'Salvarsan' . (plantaforma.org)
  • The discovery of arsphenamine, first synthesised by Alfred Bertheim and Paul Ehrlich in 1907, used to treat syphilis added to start antibacterial chemotherapy. (buddymantra.com)
  • In that sense, the first modern chemotherapeutic agent was Paul Ehrlich 's arsphenamine , an arsenic compound discovered in 1909 and used to treat syphilis . (wikidoc.org)
  • Arsphenamine was used to treat the disease syphilis because it is toxic to the bacterium Treponema pallidum, a spirochete that causes syphilis. (wikipedia.org)
  • Before that, the only antimicrobials available were the arsenicals (arsphenamine and neosalvarsan), which were used to treat syphilis. (cdc.gov)
  • used in the preparation of dyes, as a reagent for arsphenamine, anthranilic acid, antipyrine, indole, and skatole, and as a differentiating agent between true scarlet Ehrlich's reagent is recommended for nonfermenting, gram-negative bacilli and for anaerobes.2-4 PRINCIPLE Tryptophanases are intracellular enzymes that mediate the production of indole by hydrolytic activity against the amino acid, tryptophan. (web.app)
  • Before that, the only antimicrobials available were the arsenicals (arsphenamine and neosalvarsan), which were used to treat syphilis. (cdc.gov)
  • But before the late forties when penicillin became the accepted treatment, the standard treatment was the arsenicals, arsphenamine or neoarsphenamine. (brevis.com)
  • The 606th compound was one that contained arsenic and was called arsphenamine . (wiktionary.org)
  • During the 18th, 19th, and 20th centuries, a number of arsenic compounds were used as medicines, including arsphenamine (by Paul Ehrlich) and arsenic trioxide (by Thomas Fowler). (geologyscience.com)
  • From May 25, to Dec. 29, 1927, he received a course of treatment with silver arsphenamine and bismuth. (jamanetwork.com)