Inorganic salts or organic esters of arsenious acid.
Inorganic compounds that contain sodium as an integral part of the molecule.
Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions.
Inorganic or organic salts and esters of arsenic acid.
A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
A general class of integral membrane proteins that transport ions across a membrane against an electrochemical gradient.
A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
An agent that causes the production of physical defects in the developing embryo.
Oxidoreductases that specifically reduce arsenate ion to arsenite ion. Reduction of arsenate is a critical step for its biotransformation into a form that can be transported by ARSENITE TRANSPORTING ATPASES or complexed by specific sulfhydryl-containing proteins for the purpose of detoxification (METABOLIC DETOXIFICATION, DRUG). Arsenate reductases require reducing equivalents such as GLUTAREDOXIN or AZURIN.
Inorganic or organic compounds that contain arsenic.
A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.
A schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
The type species of gram negative bacteria in the genus ALCALIGENES, found in soil. It is non-pathogenic, non-pigmented, and used for the production of amino acids.
A family in the order Chromatiales, class GAMMAPROTEOBACTERIA. These are haloalkaliphilic, phototrophic bacteria that deposit elemental sulfur outside their cells.
A plant genus of the family PTERIDACEAE. Members contain entkaurane DITERPENES. The name is similar to bracken fern (PTERIDIUM).
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
A cadmium halide in the form of colorless crystals, soluble in water, methanol, and ethanol. It is used in photography, in dyeing, and calico printing, and as a solution to precipitate sulfides. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.
A family of gram-negative bacteria in the class BETAPROTEOBACTERIA. There are at least eight genera.

Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells. (1/791)

Cellular and molecular mechanisms involved in the resistance to cytotoxic heavy metals remain largely to be characterized in mammalian cells. To this end, we have analyzed a metal-resistant variant of the human lung cancer GLC4 cell line that we have selected by a step-wise procedure in potassium antimony tartrate. Antimony-selected cells, termed GLC4/Sb30 cells, poorly accumulated antimony through an enhanced cellular efflux of metal, thus suggesting up-regulation of a membrane export system in these cells. Indeed, GLC4/Sb30 cells were found to display a functional overexpression of the multidrug resistance-associated protein MRP1, a drug export pump, as demonstrated by Western blotting, reverse transcriptase-polymerase chain reaction and calcein accumulation assays. Moreover, MK571, a potent inhibitor of MRP1 activity, was found to markedly down-modulate resistance of GLC4/Sb30 cells to antimony and to decrease cellular export of the metal. Taken together, our data support the conclusion that overexpression of functional MRP1 likely represents one major mechanism by which human cells can escape the cytotoxic effects of heavy metals.  (+info)

Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. (2/791)

Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistant sublines of Chinese hamster V79 cells have now been isolated. In order to gain understanding of possible targets for arsenite's action, one arsenite-resistant subline, As/R28A, was chosen as a donor for a cDNA expression library. The library from arsenite-induced As/R28A cells was transfected into arsenite-sensitive As/S5 cells, and transfectants were selected for arsenite-resistance. Two cDNAs, asr1 and asr2, which confer arsenite resistance to arsenite-hypersensitive As/S5 cells as well as to wild-type cells, were isolated. asr1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin-like region fused to S30 ribosomal protein. Arsenite was previously shown to inhibit ubiquitin-dependent proteolysis. These results suggest that the tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite.  (+info)

Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. (3/791)

Various stresses activate the c-Jun N-terminal kinase (JNK), which is involved in the regulation of many aspects of cellular physiology, including apoptosis. Here we demonstrate that in contrast to UV irradiation, heat shock causes little or no stimulation of the JNK-activating kinase SEK1, while knocking out the SEK1 gene completely blocks heat-induced JNK activation. Therefore, we tested whether heat shock activates JNK via inhibition of JNK dephosphorylation. The rate of JNK dephosphorylation in unstimulated cells was high, and exposure to UV irradiation, osmotic shock, interleukin-1, or anisomycin did not affect this process. Conversely, exposure of cells to heat shock and other protein-damaging conditions, including ethanol, arsenite, and oxidative stress, strongly reduced the rate of JNK dephosphorylation. Under these conditions, we did not observe any effects on dephosphorylation of the homologous p38 kinase, suggesting that suppression of dephosphorylation is specific to JNK. Together, these data indicate that activation of JNK by protein-damaging treatments is mediated primarily by inhibition of a JNK phosphatase(s). Elevation of cellular levels of the major heat shock protein Hsp72 inhibited a repression of JNK dephosphorylation by these stressful treatments, which explains recent reports of the suppression of JNK activation by Hsp72.  (+info)

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. (4/791)

Gadd153, also known as chop, encodes a member of the CCAAT/enhancer-binding protein (C/EBP) transcription factor family and is transcriptionally activated by cellular stress signals. We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter. In this report, we identified components of these additional complexes as two ATF/CREB (cAMP-responsive-element-binding protein) transcription factors having differential binding activities dependent upon the time of arsenite exposure. During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined. We further demonstrated that ATF4 activates, while ATF3 represses, Gadd153 promoter activity through the C/EBP-ATF site. ATF3 also repressed ATF4-mediated transactivation and arsenite-induced activation of the Gadd153 promoter. Our results suggest that numerous members of the ATF/CREB family are involved in the cellular stress response, and that regulation of stress-induced biphasic Gadd153 expression in PC12 cells involves the ordered, sequential binding of multiple transcription factor complexes to the C/EBP-ATF composite site.  (+info)

Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. (5/791)

Teratogen-induced cell death is a common event in the pathogenesis associated with tissues destined to be malformed. Although the importance of this cell death is recognized, little information is available concerning the biochemistry of teratogen-induced cell death. We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP). Teratogen-induced cell death is also selective, i. e., some cells within a tissue die while others survive. In addition, cells within some tissues die when exposed to teratogens while cells in other tissues are relatively resistant to teratogen-induced cell death. An example of the latter selectivity is seen in the cells of the developing heart, which are resistant to the cytotoxic potential of many teratogens. We show that the absence of cell death in the heart is accompanied by the complete lack of DNA fragmentation, activtion of caspase-3 and the cleavage of PARP.  (+info)

Pathways of As(III) detoxification in Saccharomyces cerevisiae. (6/791)

Saccharomyces cerevisiae has two independent transport systems for the removal of arsenite from the cytosol. Acr3p is a plasma membrane transporter that confers resistance to arsenite, presumably by arsenite extrusion from the cells. Ycf1p, a member of the ABC transporter superfamily, catalyzes the ATP-driven uptake of As(III) into the vacuole, also producing resistance to arsenite. Vacuolar accumulation requires a reductant such as glutathione, suggesting that the substrate is the glutathione conjugate, As(GS)3. Disruption of either the ACR3 or YCF1 gene results in sensitivity to arsenite and disruption of both genes produces additive hypersensitivity. Thus, Acr3p and Ycf1p represent separate pathways for the detoxification of arsenite in yeast.  (+info)

Sodium arsenite enhances copper accumulation in human lung adenocarcinoma cells. (7/791)

In this report, we found that arsenite-resistant human lung adenocarcinoma cells, CL3R15, were more susceptible to CuCl2 than the parental CL3 cells. With the aid of atomic absorption spectrophotometry, we observed that CL3R15 cells accumulated more copper than CL3 cells. We further demonstrated that sodium arsenite treatment resulted in a dose-dependent increase of copper accumulation in the parental CL3 cells. In contrast, copper did not alter the levels of intracellular arsenite in CL3 cells treated in combination with sodium arsenite and CuCl2. Pretreatment of CL3 cells with sodium arsenite resulted in a significant increase of copper accumulation and cytotoxicity. These results indicate that intracellular copper accumulation is enhanced by arsenite. However, arsenite-enhanced copper accumulation was not observed in two fibroblastic cells, GM00220 and GM03700, derived from Menkes patients. The Menkes gene encodes a membrane pump responsible for copper exportation. Our results suggest that Menkes protein is a potential target of arsenite.  (+info)

Asp45 is a Mg2+ ligand in the ArsA ATPase. (8/791)

The ATPase activity of ArsA, the catalytic subunit of the plasmid-encoded, ATP-dependent extrusion pump for arsenicals and antimonials in Escherichia coli, is allosterically activated by arsenite or antimonite. Magnesium is essential for ATPase activity. To examine the role of Asp45, mutants were constructed in which Asp45 was changed to Glu, Asn, or Ala. Cells expressing these mutated arsA genes lost arsenite resistance to varying degrees. Purified D45A and D45N enzymes were inactive. The purified D45E enzyme exhibited approximately 5% of the wild type activity with about a 5-fold decrease in affinity for Mg2+. Intrinsic tryptophan fluorescence was used to probe Mg2+ binding. ArsA containing only Trp159 exhibited fluorescence enhancement upon the addition of MgATP, which was absent in D45N and D45A. As another measure of conformation, limited trypsin digestion was used to estimate the surface accessibility of residues in ArsA. ATP and Sb(III) synergistically protected wild type ArsA from trypsin digestion. Subsequent addition of Mg2+ increased trypsin sensitivity. D45N and D45A remained protected by ATP and Sb(III) but lost the Mg2+ effect. D45E exhibited an intermediate Mg2+ response. These results indicate that Asp45 is a Mg2+-responsive residue, consistent with its function as a Mg2+ ligand.  (+info)

Sodium arsenite exposure at concentration >5 M may induce embryotoxic and teratogenic effects in animal models. several downstream focuses on that control cell survival and apoptosis. Furthermore, the whole core transcription element circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, April4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 M) exposure. This was adopted by G2/M police arrest and induction of the mitochondrial apoptotic pathway that might become suppressed by caspase-9 and caspase-3 inhibitors. In contrast to mouse ESC D-(+)-Xylose supplier with very low endogenous IL6, mouse neural come/precursor cells (C17.2 clone immortalized by and and [18, 19]; and [20]; and [21], which could induce reprogramming fibroblasts to pluripotency. The triumvirate D-(+)-Xylose supplier of transcription factors April4, Nanog and Sox2 takes on the fundamental part in gene regulations, frequently presenting multiple localised sites in the regulatory locations of the ...
DOSE DEPENDENT EFFECTS OF SODIUM ARSENITE ON NF-kB AND INTERLEUKIN-8 IN BRONCHIAL EPITHELIAL CELLS A Thesis Submitted to the Faculty In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Pharmacology and Toxicology by Robert Ronald Roussel DARTMOUTH COLLEGE Hanover, New Hampshire July 31, 2000 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission ...
TY - JOUR. T1 - Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes. AU - Bolt, Alicia M.. AU - Douglas, Randi M.. AU - Klimecki, Walter T.. PY - 2010/11/30. Y1 - 2010/11/30. N2 - Chronic exposure to inorganic arsenic is associated with diverse, complex diseases, making the identification of the mechanism underlying arsenic-induced toxicity a challenge. An increasing body of literature from epidemiological and in vitro studies has demonstrated that arsenic is an immunotoxicant, but the mechanism driving arsenic-induced immunotoxicity is not well established. We have previously demonstrated that in human lymphoblastoid cell lines (LCLs), arsenic-induced cell death is strongly associated with the induction of autophagy. In this study we utilized genome-wide gene expression analysis and functional assays to characterize arsenic-induced effects in seven LCLs that were exposed to an environmentally relevant, minimally cytotoxic, ...
Arsenic can induce reactive oxygen species (ROS) leading to oxidative stress and carcinogenesis. Bladder is one of the major target organs of arsenic, and cyclooxygenase-2 (COX-2) may play an important role in arsenic-induced bladder cancer. However, the mechanism by which arsenic induces COX-2 in bladder cells remains unclear. This study aimed at investigating arsenic-mediated intracellular redox status and signaling cascades leading to COX-2 induction in human uroepithelial cells (SV-HUC-1). SV-HUC-1 cells were exposed to sodium arsenite and COX-2 expression, mitogen-activated protein kinase (MAPK) phosphorylation, glutathione (GSH) levels, ROS induction and Nrf2 expression were quantified. Our results demonstrate that arsenite (1-10 μM) elevates COX-2 expression, GSH levels, ROS and Nrf2 expression. Arsenite treatment for 24h stimulates phosphorylation of ERK and p38, but not JNK in SV-HUC-1 cells. Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK. Arsenite
Arsenite has long been known as a human carcinogen. The hypoxia-inducible factor-1 (HIF-1) is an important transcription factor upon hypoxia and other stresses, which is proved to be associated with the pathogenesis of several cancers. Although hypoxia-inducible factor-1α (HIF-1α) has been reported to be activated by arsenite both in vivo and in vitro, the detailed molecular mechanisms leading to HIF-1α expression and activation due to arsenite exposure have not been well understood. In the present study, we found that arsenite is able to induce HIF-1α protein accumulation in both mouse epidermal Cl41 cells and mouse embryonic fibroblasts (MEFs). Knockout of p85α in MEFs (p85α−/−) led to the deficiency of HIF-1α protein accumulation induced by arsenite exposure, suggesting that p85α is crucial for arsenite-induced stabilization of HIF-1α protein. At the same time, our studies also show that p85a exhibited an inhibition of HIF-1α protein degradation via PI-3K/Akt-dependent pathway ...
Epidemiology studies have established a strong link between lung cancer and arsenic exposure. Currently, the role of disturbed cellular energy metabolism in carcinogenesis is a focus of scientific interest. Hypoxia inducible factor-1 alpha (HIF-1A) is a key regulator of energy metabolism, and it has been found to accumulate during arsenite exposure under oxygen-replete conditions. We modeled arsenic-exposed human pulmonary epithelial cells in vitro with BEAS-2B, a non-malignant lung epithelial cell line. Constant exposure to 1 µM arsenite (As) resulted in the early loss of anchorage-dependent growth, measured by soft agar colony formation, beginning at 6 weeks of exposure. This arsenite exposure resulted in HIF-1A accumulation and increased glycolysis, similar to the physiologic response to hypoxia, but in this case under oxygen-replete conditions. This
Results: Plasma membrane (p< 0.001) and acrosome integrity (p< 0.05) of the spermatozoa were significantly reduced in sodium arsenite group compared to the control. In silymarin + sodium arsenite group, silymarin was able to significantly (p< 0.001) ameliorate the adverse effects of sodium arsenite on these sperm parameters compared to sodium arsenite group. The incubation of sperm for 180 min (control group) showed a significant (p< 0.001) decrease in acrosome integrity compared to the spermatozoa at 0 hour. The application of silymarin alone for 180 min could also significantly (p< 0.05) increase sperm acrosome integrity compared to the control ...
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The down-flow hanging sponge (DHS) reactor was used for continuous As removal treatment of As-contaminated water. The treatment scheme was: 1) As(III) in contaminated water is oxidized by arsenite-oxidizing bacteria fixed in the sponges in the reactor; 2) Fe(II) naturally existing in water is oxidized by dissolved oxygen; 3) Fe(III) is precipitated as iron hydroxide and As(V) is co-precipitated with the iron hydroxide; and finally 4) the co-precipitates are fixed in the sponges. This system could remove As from As-contaminated water on a small scale and at low cost. The results showed that, after using the DHS reactor, As and Fe concentrations in the treated water were lower than water quality standards for drinking water when Fe(II) concentration in influent was lower than 10 mg/L and the Fe/As ratio was higher than 6.67-8.42, with dependence on the Fe concentration. Additionally, even if Fe concentration is higher than 10 mg/L, the treatment system is still applicable if pH of the influent is ...
Sigma-Aldrich offers abstracts and full-text articles by [Chien-Te Chou, Hong-Ting Lin, Pai-An Hwang, Shang-Ta Wang, Cheng-Hong Hsieh, Deng-Fwu Hwang].
for toxicological evaluation and was selected for immunotoxicity studies by the chemical manager. The purpose of the range-finding study was to determine the doses of sodium arsenite to be used in an immuntoxicology protocol.. The range-finding studies were conducted in female B6C3F1 mice. The animals were administered sodium arsenite as a pellet implanted subcutaneously. The sodium-meta arsenite was purchased from Sigma Chemical Company and pelletized by Innovative Research of America. The pellets were prepared using 1, 3 and 6 mg/pellet as recommended by the producer to obtain the desired blood levels of 100, 300 and 600 ng/ml. These doses proved highly toxic and the pellets were then prepared at 0.01, 0.03 and 0.06 mg/pellet. Two studies were carried out in completing the range-finding protocol. The pellets were implanted on day 1 and the assay evaluations were performed on day 15. Dose levels of 0.01, 0.03 and 0.06 mg/pellet were used; however, the high dose of 0.06 mg/pellet resulted in the ...
23594 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant ...
To examine the hypothesis that induction of heat shock proteins by a nonthermal mechanism would confer protection against experimental sepsis.Prospective, blind, randomiz
Theres an article from 2004 about a vet who treated falcons diagnosed with CFS with Potassium Arsenite 0.05% leading to complete remission of symptoms...
S cerevisiae ACR3 protein: ACR - Arsenic Compounds Resistance; a putative membrane protein involved in Arsenite transport; has been sequenced
To evaluate the capacity of the S130P mutant protein to bind PKR, mobile lysates from WT or S130P FLAG-RAX expressing L929 cells treated with sodium arsenite
Heme oxygenase-1 is an inducible enzyme that catalyzes heme degradation and has been proposed to play a role in protecting cells against oxidative stress-related injury. We investigated the induction of heme oxygenase-1 by the tumor promoter arsenite in a chicken hepatoma cell line, LMH. We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in response to sodium arsenite treatment. This construct was used to investigate the role of mitogen-activated protein (MAP) kinases in arsenite-mediated heme oxygenase-1 gene expression. In LMH cells, sodium arsenite, cadmium, and heat shock, but not heme, induced activity of the MAP kinases extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. To examine whether these MAP kinases were involved in mediating heme oxygenase-1 gene expression, we utilized constitutively activated and dominant negative components of the ERK, JNK, and p38 MAP kinase signaling pathways. Involvement
TY - JOUR. T1 - Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. AU - Keyse, Stephen M.. AU - Tyrrell, Rex M.. PY - 1989. Y1 - 1989. N2 - We have shown that UVA (320-380 nm) radiation, hydrogen peroxide, and sodium arsenite induce a stress protein of approximately 32 kDa in human skin fibroblasts. The synthesis and cloning of cDNA from arsenite-induced mRNA populations have now allowed us to unequivocally identify the 32-kDa protein as heme oxygenase. By mRNA analysis we have shown that the heme oxygenase gene is also induced in cultured human skin fibroblasts by UVA radiation, hydrogen peroxide, cadmium chloride, iodoacetamide, and menadione. The known antioxidant properties of heme catabolites taken together with the observation of a high level of induction of the enzyme in cells from an organ not involved in hemoglobin breakdown strongly supports the proposal that the induction of heme oxygenase may ...
TY - JOUR. T1 - Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. AU - Bolt, Alicia M.. AU - Byrd, Randi M.. AU - Klimecki, Walter T.. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Arsenic is a widespread environmental toxicant with a diverse array of molecular targets and associated diseases, making the identification of the critical mechanisms and pathways of arsenic-induced cytotoxicity a challenge. In a variety of experimental models, over a range of arsenic exposure levels, apoptosis is a commonly identified arsenic-induced cytotoxic pathway. Human lymphoblastoid cell lines (LCL) have been used as a model system in arsenic toxicology for many years, but the exact mechanism of arsenic-induced cytotoxicity in LCL is still unknown. We investigated the cytotoxicity of sodium arsenite in LCL 18564 using a set of complementary markers for cell death pathways. Markers indicative of apoptosis (phosphatidylserine externalization, PARP cleavage, and sensitivity to ...
One of the key mediators of the antiviral and antiproliferative actions of interferon is double-stranded-RNA-dependent protein kinase (PKR). PKR activity is also involved in the regulation of cell proliferation, apoptosis and signal transduction. We have recently identified PACT, a novel protein activator of PKR, as an important modulator of PKR activity in cells in the absence of viral infection. PACT heterodimerizes with PKR and activates it by direct protein-protein interactions. Endogenous PACT acts as an activator of PKR in response to diverse stress signals, such as serum starvation and peroxide or arsenite treatment, and is therefore a novel, stress-modulated physiological activator of PKR. In this study, we have characterized the functional domains of PACT that are required for PKR activation. Our results have shown that, unlike the N-terminal conserved domains 1 and 2, the third conserved domain of PACT is dispensable for its binding of double-stranded RNA and inter action with PKR. ...
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This thesis is centered on the paper, Chronic Low-Level Arsenite Exposure through Drinking Water Increases Blood Pressure and Promotes Concentric Left Ventricular Hypertrophy in Female Mice. It was published in Toxicological Pathology on January 3, 2012 and represents a culmination of work done by Pablo Sanchez-Soria, Derrick Broka, Dr. Todd D. Camenisch, and myself (Sarah Lian Monks). My research, contribution, and specific participation are noted and precede the article, which was a culmination of work done over approximately a year and a half. Pablo Sanchez-Soria is a graduate student in the Department of Pharmacology and Toxicology and the primary author I worked under. The key results of the paper show arsenic induced left ventricular hypertrophy, and elevated systolic and diastolic blood pressure in exposed mice. ...
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Selected Publications Hur, H. and Reeder, R.J. (2016) Tungstate sorption mechanisms on boehmite: Systematic uptake studies and X-ray absorption spectroscopy analysis. J. Colloid. Interface Sci., 461, 249-260.. Sklute, E.C., Jensen, H.B., Rogers, A.D., Reeder, R.J. (2015) Morphological, structural, and spectral characteristics of amorphous iron sulfates, J. Geophys. Res. Planets, 120, 809-830.. Cerkez, E.B., Bhandari, N., Reeder, R.J., and Strongin, D.R. (2015) Coupled redox transformation of chromate and arsenite on ferrihydrite. Environ. Sci. Tech., 49, 2858-2866.. Szema, A.M., Reeder, R.J., Harrington, A.D., Schmidt, M., Liu, J., Golightly, M., Rueb, T., Hamidi, S.A., (2014) Iraq dust is respirable, sharp, and metal-laden and induces lung inflammation with fibrosis in mice via IL-2 upregulation and depletion of regulatory T cells. J. Occup. Environ. Med., 56, 243-251. Schmidt, M.P., Ilott, A.J., Phillips, B.L., and Reeder, R.J. (2014) Structural changes upon dehydration of amorphous calcium ...
These three diseases, described as early as the end of the 19th century, mainly attack the perennial organs of the grapevine (Vitis vinifera), leading to leaf and berry symptoms and death. As a result, grapevine trunk diseases are detrimental to the resilience of the wine-growing heritage. Moreover, no grapevine taxa, either cultivated or wild, are known to be resistant to trunk diseases. Over the past few decades, the frequency of symptoms of these diseases has increased considerably worldwide. For example, disease incidence values that were estimated over 4 years in approximately 700 French vineyards, including affected trunk disease and dead plants, showed that approximately 10% of productive plants were affected. Sodium arsenite was the sole treatment that had a potential effect against these diseases, especially esca, but it has been prohibited, beginning in 2000, because of its toxicity both to the environment and to humans. The lack of strategies for fighting the diseases, new pruning ...
Quanto tempo dura o efeito do viagra 50mg - Inquire about the care needed when possible. Also, pharmacologic therapy with sodium arsenite and lewisite demonstrate that when food enters it.
Sigma-Aldrich offers abstracts and full-text articles by [Huan Xu, Xixi Zhou, Xia Wen, Fredine T Lauer, Ke Jian Liu, Laurie G Hudson, Lauren M Aleksunes, Scott W Burchiel].
When confronted with environmental stress, cells either activate defence mechanisms to survive, or initiate apoptosis, depending on the type of stress. Certain types of stress, such as hypoxia, heatshock and arsenite (type 1 stress), induce cells to assemble cytoplasmic stress granules (SGs), a majo …
English: Soil and water sites were sampled at a South African antimony mine with elevated levels of arsenic due to the refining process. Enriched media yielded six pure bacterial cultures able to grow in both arsenite and ...
Chemical genetics in yeast has shown great potential for clarifying the pharmacology of various drugs. Investigating these results from a systems perspective has uncovered many facets of natural chemical tolerance, but many cellular interactions of chemicals still remain poorly understood. To uncover previou
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TY - JOUR. T1 - Decreasing arsenic accumulation in rice by overexpressing OsNIP1;1 and OsNIP3;3 through disrupting arsenite radial transport in roots. AU - Sun, Sheng Kai. AU - Chen, Yi. AU - Che, Jing. AU - Konishi, Noriyuki. AU - Tang, Zhong. AU - Miller, Anthony J.. AU - Ma, Jian Feng. AU - Zhao, Fang Jie. N1 - Funding Information: The work was supported by the Natural Science Foundation of China (31520103914), the Ministry of Science and Technology Key R&D program (2016YFD0100704), the special fund for agro-scientific research in the public interest (201403015), the Innovative Research Team Development Plan of the Ministry of Education of China (Grant no. IRT_17R56), the Fundamental Research Funds for the Central Universities and by Grant-in-Aid for Specially Promoted Research (JSPS KAKENHI Grant no. 16H06296 to J.F.M.). Y.C. and A.J.M. were funded by the UK Biotechnological and Biological Sciences Research Council (BBSRC) Institute Strategic Programme Grant Molecules from Nature ...
TY - JOUR. T1 - Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. AU - Keyse, Stephen M.. AU - Tyrrell, Rex M.. PY - 1987/10/25. Y1 - 1987/10/25. N2 - We have analyzed the pattern of protein synthesis in solar near ultraviolet (334 nm, 365 nm) and near visible (405 nm) irradiated normal human skin fibroblasts. Two hours after irradiation we find that one major stress protein of approximately 32 kDa is induced in irradiated cells. This protein is not induced by ultraviolet radiation at wavelengths shorter than 334 nm and is not inducible by heat shock treatment of these cells. Although sodium arsenite, diamide, and menadione all induced a 32-kDa protein, they also induced the major heat shock proteins. In contrast, the oxidizing agent, hydrogen peroxide, induced the low molecular weight stress protein without causing induction of the major heat shock proteins. A comparison of the 32-kDa proteins induced by ...
Resistance to arsenite (As(III)) by cells is generally accomplished by arsenite efflux permeases from Acr3 or ArsB unrelated families. We analyzed the function of three Acr3 proteins from Corynebacterium glutamicum, CgAcr3-1, CgAcr3-2, and CgAcr3-3. CgAcr3-1 conferred the highest level of As(III) resistance and accumulation in vivo. CgAcr3-1 was also the most active when everted membranes vesicles from Escherichia coli or C. glutamicum mutants were assayed for efflux with different energy sources. As(III) and antimonite (Sb(III)) resistance and accumulation studies using E. coli or C. glutamicum arsenite permease mutants clearly show that CgAcr3-1 is specific for As(III). In everted membrane vesicles expressing CgAcr3-1, dissipation of either the membrane potential or the pH gradient of the proton motive force did not prevent As(III) uptake, whereas dissipation of both components eliminated uptake. Further, a mutagenesis study of CgAcr3-1 suggested that a conserved cysteine and glutamate are ...
1. A hypothesis is given concerning the action of urethan and arsenite on malignant growth. Two assumptionsares made:- (a) the enzyme system responsible for energy production in malignant tumours is working at maximal rate, contrary to the corresponding enzyme system in normal tissues. (b) a given concentration of urethan or ... read more arsenite blocks an equal part of the sensitive enzyme(s), by which a measurable effect of a small concentration of these inhibitors on the catabolism will only be obtained in case of maximal turnover rate. 2. Experiments with kidney and liver minces and with yeast have shown that indeed the inhibition caused by urethan and arsenite increases with increasing rate of respiration or fermentation. 3. If the enzyme concentration is not considered to be negligible as compared to the substrate concentration, as is done in the theory of and , the increase of inhibition with increasing turnover number can be made plausible by enzyme kinetics for the much simplified case ...
Mesoporous pellet adsorbent developed from mixing at an appropriate ratio of natural clay, iron oxide, iron powder, and rice bran was used to investigate the optimization process of batch adsorption parameters for treating aqueous solution coexisting with arsenate and arsenite. Central composite design under response surface methodology was applied for optimizing and observing both individual and interactive effects of four main influential adsorption factors such as contact time (24-72 h), initial solution pH (3-11), adsorbent dosage (0-20 g/L) and initial adsorbate concentration (0.25-4.25 mg/L). Analysis of variance suggested that experimental data were better fitted by the quadratic model with the values of regression coefficient and adjusted regression coefficient higher than 95%. The model accuracy was supported by the correlation plot of actual and predicted adsorption efficiency data and the residual plots. The Pareto analysis suggested that initial solution pH, initial adsorbate concentration,
Fowler , P A , Drake , A J , OShaughnessy , P J , Bhattacharya , S , Raab , A , Sinclair , K D , Feldmann , J & Meharg , A A 2016 , Comment on Effects of Arsenite during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Diseases in Male Mice and Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Trends and Scientific Gaps Environmental Health Perspectives , vol 124 , no. 6 , pp. A99-A99 . DOI: 10.1289/ehp. ...
Abstract: Antioxidant Actions of Dried Flower Extracts of Hibiscus sabdariffa L. On Sodium Arsenite - Induced Oxidative Stress in Rats
Influential parameters to produce iron-coated ZSM-5 zeolite including iron loading concentration, calcination temperature and time, synthesis temperature and mixing intensity were investigated. Results showed that the optimized iron-coated ZSM-5 nano-adsorbent is produced if 40 wt.% iron loading concentration at 30 °C synthesis temperature under 60 rpm mixing intensity and 400 °C calcination temperature for 3 hrs are applied. Also, optimization of some parameters such as pH, adsorbent dose, contact time and temperature for removal of arsenite from aqueous solution with 400 μg/L initial concentration was considered. Evidently, the highest adsorption of arsenite occurred under pH 7, adsorbent dose 2.5 g/L, contact time 30 min and temperature 40 °C. Kinetic and isotherm models studied showed that arsenite adsorption by iron-coated ZSM-5 follows pseudo-third order equation and well fitted with Langmuir isotherm model. Evaluation showed that the optimized iron-coated ZSM-5 zeolite is able to ...
Learn more about Chemical Stress Test at Reston Hospital Center DefinitionReasons for TestPossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
When cells are subjected to stress, such as heat shock, genes associated with growth are downregulated and expression of proteins believed to increase cellular survival, such as HSP70, are selectively upregulated. In eukaryotes, this regulation operates at multiple levels: transcription initiation may be enhanced via factors specific for heat shock-genes, whereas for other genes there is selective inhibition of splicing and nuclear export of mRNAs (Bond, 2006).. Stress also influences the fate of cytoplasmic mRNA in eukaryotes. Treatment of mammalian cells with a variety of stresses, such as arsenite or heat shock, results in the relocation of most mRNAs from polysomes to cytoplasmic foci called stress granules (Kedersha et al., 1999). These contain the small ribosomal subunit (Kedersha et al., 2002), the translation-initiation factors eIF2, eIF3, eIF4E and eIF4G (Kedersha et al., 2002; Kimball et al., 2003), the poly(A)-binding protein (Kedersha et al., 1999), DHH1 (also known as DDX6, Rck, ...
This picture was taken by me a long time ago (6 years, i think). Contrary to the name of the blog, this is not GFP. To take this picture, I performed Immunofluorescence experiment. The procedure is as follows: Cells are treated with whatever you are invetigating (in this case - cells were treated with 0.5mM arsenite…
The influence of ethylenediaminetetraacetic acid (EDTA) and chemical species on arsenic accumulation in aquatic floating macrophyte Spirodela polyrhiza L. (duckweed) was investigated. The uptake of inorganic arsenic species (arsenate; As(V) and arsenite; As(III)) into the plant tissue and their adsorption on iron plaque of plant surfaces were significantly (p,0.05) higher than those of organic species (monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA)). The addition of EDTA to the culture media increased the uptake of As(V) and As(III) into the plant tissue though the MMAA and DMAA uptake were not affected. About 46% of the inorganic arsenic species were desorbed or mobilized from iron plaque by EDTA. Desorption of organic arsenic species was not affected by EDTA addition because the co-precipitation occurs only with inorganic species. Phosphate uptake was not affected by EDTA though its concentration in citrate-bicarbonate-EDTA (CBE)-extract was much higher than that of plant ...
In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and glutaredoxin 1 (Grx1). The three ligands must be present simultaneously for reduction to occur. ArsA and ArsB form an anion-translocating ATPase. The ArsB protein is distinguished by its overall hydrophobic ...
RNA helicases are vital components of various pathways for post-transcriptional gene regulation. TgHoDI is a newly identified member of the DEAD-box RNA helicase family in Toxoplasma gondii. This study was aimed at characterizing the function of TgHoDI in post-transcriptional regulation during various stages of the parasite life cycle. Through immunofluorescence analyses, TgHoDI was found to colocalize with mRNA aggregates in cytoplasmic foci. Furthermore, colocalization studies of TgHoDI with PABPC3 identified these proteins as components of RNA aggregates known as stress granules. Cycloheximide and arsenite treatment of extracellular parasites revealed the presence of mechanisms involved in the determination of mRNA fate in Toxoplasma. Also, TgHoDI was found to functionally compliment the temperature sensitive phenotype in Δdhh1 yeast, validating its role in stress response. These findings confirm that TgHoDI is a vital component in the formation of stress granules and possibly involved in the
Base excision repair (BER) is crucial for development and for the repair of endogenous DNA damage. However, unlike nucleotide excision repair, the regulation of BER is not well understood. Arsenic, a well-established human carcinogen, is known to produce oxidative DNA damage, which is repaired primarily by BER, while high doses of arsenic can also inhibit DNA repair. However, the mechanism of repair inhibition by arsenic and the steps inhibited are not well defined. To address this question we have investigated the regulation of DNA polymerase β (Pol β) and AP endonuclease (APE1), in response to low, physiologically relevant doses of arsenic. GM847 lung fibroblasts and HaCaT keratinocytes were exposed to sodium arsenite, As(III), and mRNA, protein levels and BER activity were assessed. Both Pol β and APE1 mRNA exhibited significant dose-dependant down regulation at doses of As(III) above 1 µM. However, at lower doses Pol β mRNA and protein levels, and consequently, BER activity were ...
According to recent reports, millions of people across the globe are suffering from arsenic (As) toxicity. Arsenic is present in different oxidative states in the environment and enters in the food chain through soil and water. In the agricultural field, irrigation with arsenic contaminated water, that is, having a higher level of arsenic contamination on the top soil, which may affects the quality of crop production. The major crop like rice (Oryza sativa L.) requires a considerable amount of water to complete its lifecycle. Rice plants potentially accumulate arsenic, particularly inorganic arsenic (iAs) from the field, in different body parts including grains. Different transporters have been reported in assisting the accumulation of arsenic in plant cells; for example, arsenate (AsV) is absorbed with the help of phosphate transporters, and arsenite (AsIII) through nodulin 26-like intrinsic protein (NIP) by the silicon transport pathway and plasma membrane intrinsic protein aquaporins. Researchers and
Background: The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells. The mechanism of mammalian JNK activation by cadmium and sodium arsenite involves toxicant-induced oxidative stress. The study of mammalian signaling pathways to JNK is complicated by the significant degree of redundancy among upstream JNK regulators, especially at the level of JNK kinase kinases (JNKKK). Results: Using Drosophila melanogaster S2 cells, we demonstrate here that cadmium and arsenite activate Drosophila JNK (D-JNK) via oxidative stress as well, thus providing a simpler model system to study JNK signaling. To elucidate the signaling pathways that lead to activation of D-JNK in response to cadmium or arsenite, we employed RNA interference (RNAi) to knock down thirteen upstream regulators of D-JNK, either singly or in combinations of up to seven at a time. Conclusion: D
Information about the open-access article Arsenic accumulation in rice: Consequences of rice genotypes and management practices to reduce human health risk in DOAJ. DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed journals.
I was told that someone could die of arsenic toxicity from eating a lot of shrimps/prawns. Im sure a lot means A LOT. Could you explain how this could happen and what happens in the system, and how to avoid/cure it? Thanl you ...
The substance may have effects on the skin, mucous membranes, bone marrow, blood, central nervous system, peripheral nervous system and liver. This may result in pigmentation disorders, perforation of the nasal septum, anaemia, nervous system impairment and liver impairment. This substance is carcinogenic to humans. Causes toxicity to human reproduction or development ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
2000, describes a method for removing arsenic from fly ash, in which arsenic is recovered as scorodite. The first treatment stage of the arsenic-containing material is the oxidation of trivalent arsenic (As(lll)) into pentavalent arsenic (As(V)) with a gas containing sulphur dioxide and oxygen in oxidising conditions, in which arsenic does not precipitate. After this, arsenic is precipitated in atmospheric conditions, in which the Fe(III)/As(V) mole ratio is specified as 1. Precipitation is carried out either in one or several stages, but precipitation as scorodite demands the over-saturation of the solution, which is achieved by recycling scorodite crystals to the first precipitation reactors and simultaneously neutralising the suspension. A beneficial pH range is around 1-2 and this is maintained by feeding a suitable neutralising agent into the precipitation stage. In these conditions, arsenic can be precipitated to the level of 0.5 g/l. The final arsenic removal to a level below 0.1 mg/l is ...
Trivalent arsenic [As(III)] is currently approved by the FDA for the treatment of chronic and acute leukemias. However, As(III) has also demonstrated damaging effects on human health, including development of cardiovascular disease, diabetes, and cancer. Further, As(III) is a potent angiogenic agent …
Spirulina is blue - green algae that grow both in fresh and salt water. For many years, the alga has used for various health purposes around the world. This nutrient-rich alga is a natural supplement that provides amazing health benefits to the users. Here are the benefits of Spirulina.. #1. Detoxing properties The studies show that regular intake of Spirulina can effectively detox heavy metals such as Arsenic. It has been demonstrated that chronic Arsenic toxicity is common in most parts of the world. Millions of people consume Arsenic through drinking water. Apparently, there is no specific treatment for arsenic toxicity. However, the clinical trials have proven that Spirulina can significantly reduce the level of toxicity in the body.. #2. Packed with essential nutrients Our bodies require essential nutrients for proper functioning. Fortunately, Spirulina is rich in essential nutrients and low in calories. The algae manufacture its food through photosynthesis thus making it rich in vital ...
ABSTRACTHuman arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. The objective of this study was to investigate the diversity of the AS3MT gene at the global level. The distribution of 18 single nucleotide polymorphisms (SNPs) in AS3MT was perfor
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Skin is the largest organ of the body.It is a major barrier between the body and the external environment. Main Functions of skin: Protection: It forms a protection layer against mechanical/thermal/chemical stress, infection Sensation: skin contains touch, pressure, pain and … Read More … ...
Skin is the largest organ of the body.It is a major barrier between the body and the external environment. Main Functions of skin: Protection: It forms a protection layer against mechanical/thermal/chemical stress, infection Sensation: skin contains touch, pressure, pain and … Read More … ...
... has been determined to be part of the vanadate, arsenite, and arsenate groups. Analytical methods were used to ... arsenite)) and decorated by peripheral tetrahedra (As5+O4 (arsenate)). Each peripheral tetrahedra shares three of its four ...
1310 Arsenite Schism of Constantinople is officially ended by the reconciliation of the Arsenites to the Josephites, in a ... 1265-1310 Arsenite Schism of Constantinople, beginning when Patr. Arsenius Autorianus excommunicated emperor Michael VIII ... 18(1948), 202-220.) Alexander P. Kahzdan (Ed). "Arsenites." The Oxford Dictionary of Byzantium. Oxford University Press, 2012. ...
... (EC 1.20.2.1, arsenite oxidase) is an enzyme with systematic name arsenite:cytochrome c ... vanden Hoven RN, Santini JM (June 2004). "Arsenite oxidation by the heterotroph Hydrogenophaga sp. str. NT-14: the arsenite ... This enzyme catalyses the following chemical reaction arsenite + H2O + 2 oxidized cytochrome c ⇌ {\displaystyle \ ... "Arsenite oxidase from Ralstonia sp. 22: characterization of the enzyme and its interaction with soluble cytochromes". The ...
Arsenite is the most stable soluble form of arsenic in reducing environments and arsenate, which is less mobile than arsenite, ... Arsenite is more soluble and mobile than arsenate. Many species of bacteria can transform arsenite to arsenate in anoxic ... Chemoautotrophic arsenite oxidizers (CAO) and heterotrophic arsenite oxidizers (HAO) convert As(III) into As(V). CAO combine ... Arsenite of lime and arsenate of lead were used widely as insecticides until the discovery of DDT in 1942. The toxicity of ...
Arsenite minerals are much less common. Both the Dana and the Strunz mineral classifications place the arsenates in with the ...
... , also called Schloss Green, is chemically a cupric hydrogen arsenite (also called copper arsenite or acidic ... This produced a sodium arsenite solution. Added to a copper sulfate solution, it produced a green precipitate of effectively ... copper arsenite salt (CuHAsO 3 and Cu(AsO 3) 2·3H 2O)), neutral copper orthoarsenite (3CuO·As 2O 3·2H 2O), copper arsenate ( ... Arsenites, Copper(II) compounds, Inorganic pigments, Inorganic insecticides). ...
Thus, it dissolves readily in alkaline solutions to give arsenites. It is less soluble in acids, although it will dissolve in ... Bulk arsenic-based compounds sodium arsenite and sodium cacodylate are derived from the trioxide.[citation needed] A variety of ...
The systematic name of this enzyme class is arsenite:azurin oxidoreductase. This enzyme is also called arsenite oxidase. The ... Ellis PJ, Conrads T, Hille R, Kuhn P (2001). "Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in ... Arsenate reductase (azurin) (EC 1.20.9.1) is an enzyme that catalyzes the chemical reaction arsenite + H2O + 2 azurinox ⇌ {\ ... Anderson GL, Williams J, Hille R (1992). "The purification and characterization of arsenite oxidase from Alcaligenes faecalis, ...
nov., an arsenite-oxidizing bacterium isolated from agricultural soil in Thailand". J. Gen. Appl. Microbiol. 58 (3): 245-51. ... C. terrae has an arsenite-oxidizing ability. "Genus: Comamonas". Retrieved 2013-05-10. "NBRC 106524 Strain Passport - ...
nov., an arsenate-respiring and arsenite-oxidizing bacterium isolated from hydrothermal sediment". International Journal of ... Marinobacter santoriniensis can metabolize arsenate and arsenite. A.C. Parte. "Marinobacter". LPSN. Retrieved 2016-08-18. " ...
MM-1 isolated from a soil and identification of arsenite oxidase gene". Journal of Hazardous Materials. 262: 997-1003. doi: ... Bahar, Md Mezbaul; Megharaj, Mallavarapu; Naidu, Ravi (2013-11-15). "Kinetics of arsenite oxidation by Variovorax sp. ...
The generalized reaction catalyzed by members of the ACR3 family is: arsenite or antimonite (in) → arsenite or antimonite (out ... The former yeast protein is present in the plasma membrane and pumps arsenite and antimonite, but not arsenate, tellurite, ... Mansour, Nahla M.; Sawhney, Mrinalini; Tamang, Dorjee G.; Vogl, Christian; Saier, Milton H. (2007-02-01). "The bile/arsenite/ ... Aaltonen, Emil K. J.; Silow, Maria (2008-04-01). "Transmembrane topology of the Acr3 family arsenite transporter from Bacillus ...
nov., an arsenite-oxidizing bacterium from Thai soil". Antonie van Leeuwenhoek. 106 (6): 1239-46. doi:10.1007/s10482-014-0294-1 ... Flavobacterium arsenitoxidans is a Gram-negative, arsenite-oxidizing, non-spore-forming, rod-shaped and aerobic bacterium from ...
nov., an arsenite-resistant bacterium isolated from soil". International Journal of Systematic and Evolutionary Microbiology. ... Xenophilus arseniciresistens is a Gram-negative, aerobic, arsenite-resistant and motile bacterium from the genus Xenophilus ...
Arsenite or Antimonite (out). The overall reaction catalyzed by ArsB-ArsA is: Arsenite or Antimonite (in) + ATP ⇌ Arsenite or ... Arsenic toxicity Arsenite Antimonite Ion transporter Ion transporter superfamily ARC3 family Arsenite-Antimonite efflux ... Arsenite resistance (Ars) efflux pumps of bacteria may consist of two proteins, ArsB (TC# 2.A.45.1.1; the integral membrane ... These pumps actively expel both arsenite and antimonite. Homologues of ArsB are found in Gram-negative and Gram-positive ...
Ceballos-Escalera, A., et al., Electro-bioremediation of nitrate and arsenite polluted groundwater. Water Res, 2021. 190: p. ... or in combination with other co-contaminants such as arsenite. In comparison to traditional denitrification which involves ...
nov., an arsenite-resistant bacterium isolated from soil". International Journal of Systematic and Evolutionary Microbiology. ...
... arsenite, hexachlorobenzene, and nickel compounds. Many teratogens exert specific effects on the fetus by epigenetic mechanisms ...
Induced by oxidative stress generated by arsenite treatment. Binding of nitric oxide (NO) to the heme iron in the N-terminal ...
... is a species of arsenite-oxidizing bacterium. Salmassi, Tina M.; Venkateswaren, Kasthuri; Satomi, ... Masataka; Newman, Dianne K.; Hering, Janet G. (2002). "Oxidation of Arsenite by Agrobacterium albertimagni , AOL15, sp. nov., ...
On heating, Related to these are the nitrite nitrates and arsenate arsenites. Petrosyants, S. P. (December 2013). "Coordination ...
... cupric arsenite (CuHAsO3). Green earth: also known as terre verte and Verona green (K[(Al,Fe3+),(Fe2+,Mg](AlSi3,Si4)O10(OH)2). ... made by a reaction of sodium arsenite with copper(II) acetate. While it makes a beautiful rich green, the color of the emerald ...
... cupric arsenite (CuHAsO3). Other pigments Green earth: also known as terre verte and Verona green (K[(Al,Fe3+),(Fe2+,Mg](AlSi3, ...
The toxic compounds in arsenic are arsenate and arsenite; each is acted upon differently by the bezoars: arsenate is removed by ... being exchanged for phosphate in brushite found in the stones, while arsenite is bound to sulfur compounds in the protein of ...
Arsenite (As(+3)), has a pKa of 9.3, and occurs at a neutral or acidic pH as As(OH)3. Arsenite in water can be thought of as an ... On the other hand, arsenite is more common in anaerobic environments, more mobile, and more toxic than arsenate. Arsenite is 25 ... Living cells (microbial or human) are generally exposed to arsenic as arsenate or arsenite. Arsenate (As(+5)) has a pKa of 7.0 ... In microbial biofilms growing on the rock surfaces of anoxic brine pools fed by hot springs containing arsenite and sulfide at ...
The presence or absence of P does not affect the uptake of arsenite, which translocates more easily than arsenate. C. Tu, L.Q. ... arsenite as a noncompetitive inhibitor). Priel 1995. Gurta et al. 1994 L.E. Bennetta; J.L. Burkheada; K.L. Halea; N. Terry; M. ... the plants then absorbs 10 times more arsenate than arsenite. If on the other hand the P supply is increased, As uptake ...
... has the ability to oxidize arsenite to arsenate. The complete genome of A. arsenitoxydans has been ...
nov., an arsenite-resistant bacterium isolated from iron-mined soil". International Journal of Systematic and Evolutionary ... Lysobacter arseniciresistens is a Gram-positive, rod-shaped, aerobic, arsenite-resistant and motile bacterium from the genus of ...
This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out ... thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion. Carlin A ... ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite ...
2001) with arsenite-exposed human lung A549, kidney UOK123, UOK109 and UOK121 cells isolated eight different DNA fragments by ... Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M (November 1996). "The tumor promoter arsenite stimulates AP-1 activity by ... MRP1-overexpressing lung tumor GLC4/Sb30 cells poorly accumulate arsenite and arsenate. This is mediated through MRP-1 ... Zhong CX, Mass MJ (July 2001). "Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures ...
Some arsenite salts can be prepared from an aqueous solution of As2O3. Examples of these are the meta-arsenite salts and at low ... A number of different arsenite anions are known: AsO3−3 ortho-arsenite, an ion of arsenous acid, with a pyramidal shape (AsO−2) ... Well known examples of arsenites include sodium meta-arsenite which contains a polymeric linear anion, (AsO−2)n, and silver ... IUPAC have recommended that arsenite compounds are to be named as arsenate(III), for example ortho-arsenite is called ...
... Vartika Sinha, Ritesh Mishra, Abhinav Kumar, ... Amplification of arsH Gene in Lactobacillus acidophilus Resistant to Arsenite. Biotechnology, 10: 101-107. DOI: 10.3923/biotech ... In the present study in vitro resistance against arsenite (up to 32 ppm) was developed in Lactobacillus acidophilus and the ... The arsenite-resistant strain IITR-RKU1 showed similar growth phase patterns to that of normal parent strain in the absence or ...
Sodium arsenite*. Aluminum phosphide*. Fentanyl*. Sodium azide. Ammonium metavanadate*. Fluoroacetamide*. Sodium fluoride*. ...
SODIUM ARSENITE. 601. 7784-46-5. 246. URANIUM-233. 601. 13968-55-3. ...
Arsenite methyltransferase. Arsenite resistance. 25. NA. dfrG. Trimethoprim-resistance dihydrofolate reductase. Antimicrobial ...
Butylated hydroxytoluene(BHT) and sodium arsenite enhanced the nitrofurantoin induced prophage-lambda induction in E. coli GY ... Induction of prophage lambda by nitrofurantoin and its modulation by butylated hydroxytoluene, sodium arsenite and alpha ... Induction of prophage lambda by nitrofurantoin and its modulation by butylated hydroxytoluene, sodium arsenite and alpha ... were achieved with 100 micrograms/ml BHT and 250 micrograms/ml sodium arsenite corresponding to a nitrofurantoin concentration ...
Arsenite impairs nucleotide excision repair, [2] and it may also affect gene expression by increasing or decreasing DNA ... Genotoxic effects of sodium arsenite on human cells. Mutat Res. 1992 Dec 16. 284(2):215-21. [QxMD MEDLINE Link]. ... potassium arsenite. [12] In Asia, Chinese proprietary herbal medicine has been the mainstay of remedies for thousands of years ...
Nitric oxide and nitrogen dioxide may be measured either separately or collectively as oxides of nitrogen (NOx) by either manual or automated techniques. The automated…. ...
Arsenites / toxicity* * Biomarkers / analysis * Bronchi / metabolism * Cells, Cultured * Cyclin D1 / genetics * Cyclin D1 / ...
Arsenite Oxidation by a Poorly Crystalline Manganese-Oxide. 2. Results from X-ray Absorption Spectroscopy and X-ray Diffraction ...
Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity.. This entry was posted by admin on April 22, 2019 ... The present study investigated effects of GA against sodium arsenite (SA)-induced renal and hepatic toxicity. Thirty-five rats ... Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats. ...
Phenotyping the growth rates of yeast strains in copper- and arsenite-rich medium.. The homozygous diploid versions of the 12 ... To examine their conditional growth rates in copper- and arsenite-rich environment, we mixed 350 μl conditional medium (CuCl2 ( ... 0.38 mM) and arsenite (As(III), 3 mM) for the two environment respectively) with 10 μl saturated culture to the wells of ... supplemented with varying arsenite concentrations (0, 1, 2, and 3 mM). Using the deviations between the POL phenotype and the ...
This medical management guide focuses specifically on arsenic trioxide (an arsenite), which is one of the most toxic forms of ... Ingestion is the main route of exposure to other arsenites and arsenates for the general population. Overexposure may result ... and are several times less toxic than the arsenites. Elemental arsenic has a gray metal-like appearance, is insoluble in water ...
... ... Physiological responses and transcriptome analyses of upland rice following exposure to arsenite and arsenate , Environmental ...
In summary, IDTs RF portfolio replaces gallium arsenite parts, results in higher reliability, provides better signal-to-noise ... In summary, IDTs RF portfolio replaces gallium arsenite parts, results in higher reliability, provides better signal-to-noise ... improves reliability by replacing gallium arsenite with silicon; improves data throughput by optimizing signal-to-noise ... improves reliability by replacing gallium arsenite with silicon; improves data throughput by optimizing signal-to-noise ...
... and arsenites. This work led to the field of stereochemistry. ... and Arsenites (3 of 4)." Louis Pasteur Lecture Notes on Crystal ... Louis Pasteur lecture notes on crystal structure, tartaric acid, and arsenites (3 of 4) *Part of Louis Pasteur lecture notes on ... Louis Pasteur lecture notes on crystal structure, tartaric acid, and arsenites (3 of 4) ... Louis Pasteur lecture notes on crystal structure, tartaric acid, and arsenites (1 of 4) ...
Arsenite exposure resulted in attenuation of FoxO DNA binding and in nuclear exclusion of FoxO1a-EGFP. A 24-h exposure of HepG2 ... Interestingly, arsenite-induced long-term effects on G6Pase and SelP mRNA or SelP protein levels were not blocked by the PI3K ... Arsenite exposure resulted in attenuation of FoxO DNA binding and in nuclear exclusion of FoxO1a-EGFP. A 24-h exposure of HepG2 ... Interestingly, arsenite-induced long-term effects on G6Pase and SelP mRNA or SelP protein levels were not blocked by the PI3K ...
ZINC ARSENITE or ZINC ARSENATE AND ZINC ARSENITE MIXTURE ... ZINC ARSENATE, ZINC ARSENITE or ZINC ARSENATE AND ZINC ARSENITE ...
Arsenite tolerance in rice (Oryza sativa L.) involves coordinated role of metabolic pathways of thio.... October 2012 · ... cultivar were exposed to arsenite (0-25 μM) for 7 days for various biochemical analyses using spectrophotometer, HPLC and ICPMS ...
keywords = "Arsenite, ECV304, Fas ligand, Reactive oxygen species (ROS)",. author = "Tsai, {S. H.} and Ming-Shium Hsieh and L. ... Chronic exposure to arsenite is associated with vascular disease, such as arteriosclerosis. However, the cellular mechanisms ... Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species. In: Toxicology Letters. ... Suppression of Fas ligand expression on endothelial cells by arsenite through reactive oxygen species. / Tsai, S. H.; Hsieh, ...
Arsenite (As(III)) is often the predominant valence state at the point of discharge but is rapidly oxidized to arsenate (As(V ... Arsenite (As(III)) is often the predominant valence state at the point of discharge but is rapidly oxidized to arsenate (As(V ... Arsenite (As(III)) is often the predominant valence state at the point of discharge but is rapidly oxidized to arsenate (As(V ... Arsenite (As(III)) is often the predominant valence state at the point of discharge but is rapidly oxidized to arsenate (As(V ...
We report here a new electrochemical method for the selective detection of ultratrace amount of arsenite (AsO2-, As3+) using a ... The sensitivity was good enough to detect arsenite at levels lower than the current EPA standard. This modified electrode ... Flow injection analysis of an ultratrace amount of arsenite using a Prussian blue-modified screen-printed electrode. ...
04.JM.15 04 - OXIDES (Hydroxides, V[5,6] vanadates, arsenites, antimonites, bismuthites, sulfites, selenites, tellurites, ...
Scope Notes: As of 2004, used for the mineral group only where specific minerals are numerous or unavailable. May also be used for geochemical studies ...
... potassium arsenite) are at risk. Exposure to arsenic may increase the risk of angiosarcoma of the liver. ...
E,F) Primary fibroblasts from WT and FAIM KO mice were subjected to menadione-induced (E) and arsenite-induced (F) oxidative ... 2008). Differential roles for Nrf2 and AP-1 in upregulation of HO-1 expression by arsenite in murine embryonic fibroblasts. ... and by arsenite (Figure 1F) to be much greater in FAIM-deficient primary fibroblasts as compared to WT fibroblasts. In both ... and arsenite- (Harada et al., 2008; Kim et al., 2015) induced oxidative stress. Consistent with the cell line results, we found ...
Coenzyme Q10 counteracts testicular injury induced by sodium arsenite in rats.Mar 25, 2011. ...
  • Well known examples of arsenites include sodium meta-arsenite which contains a polymeric linear anion, (AsO−2)n, and silver ortho-arsenite, Ag3AsO3, which contains the trigonal AsO3−3 anion. (wikipedia.org)
  • Sodium arsenite is used in the water gas shift reaction to remove carbon dioxide. (wikipedia.org)
  • IMSEAR at SEARO: Induction of prophage lambda by nitrofurantoin and its modulation by butylated hydroxytoluene, sodium arsenite and alpha tocopherol. (who.int)
  • Butylated hydroxytoluene(BHT) and sodium arsenite enhanced the nitrofurantoin induced prophage-lambda induction in E. coli GY 5027(lambda) cells in a dose dependent manner. (who.int)
  • The maximum modulations in induction level (I/Io) were achieved with 100 micrograms/ml BHT and 250 micrograms/ml sodium arsenite corresponding to a nitrofurantoin concentration of 15 micrograms/ml and were found significant on statistical analysis. (who.int)
  • Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity. (genx-digital.com)
  • Gallic acid ameliorates sodium arsenite-induced renal and hepatic toxicity in rats. (genx-digital.com)
  • The present study investigated effects of GA against sodium arsenite (SA)-induced renal and hepatic toxicity. (genx-digital.com)
  • Coenzyme Q10 counteracts testicular injury induced by sodium arsenite in rats. (greenmedinfo.com)
  • As swarms of locusts (aka grasshoppers) descended "like a plague to destroy green things in the Near East," bedouins enlisted the help of walls of zinc, which killed the wild horde in droves, and sodium arsenite (mixed with bran and molasses, for fiber and flavor), which they would sprinkle in locust territory to poison them. (popsci.com)
  • A. Adetutu, O. A. Odunola, O. A. Owoade, O. A. Adeleke and O. A. Amuda, "Anticlastogenic Effects of Hibiscus sabdariffa Fruits against Sodium Arsenite-Induced Micronuclei Formation in Erythrocytes in Mouse Bone Marrow," Phytotherapy Research, Vol. 18, No. 10, 2004, pp. 862-864. (scirp.org)
  • The use of inorganic arsenicals (sodium arsenite and arsenic trioxide) as herbicides has been reduced greatly because of livestock losses, the long-lasting effects on the environment, and their association with causing cancer. (merckvetmanual.com)
  • The pesticides, which contain sodium arsenite, are now banned, but were used by Murat to treat his vines for esca, a parasitic fungi that attacks the trunks of grapevines. (thedrinksbusiness.com)
  • The major arsenic species extracted from all samples were arsenate and arsenite, which are toxic forms of arsenic. (ubc.ca)
  • Arsenite exposure significantly lowered all brain functions (neurochemicals, AChE, and BDNF) as well as cellular antioxidant activities, increased inflammatory and oxidative stress biomarkers, and the antiapoptotic Bcl2 gene, and upregulated apoptotic Bax and Casp3 genes. (edu.sa)
  • The present study aimed at investigating the effect of short and long-term exposure to arsenite on insulin signaling in HepG2 human hepatoma cells, the role of PI3K/Akt signaling therein and the modulation of target genes controlled by insulin. (edu.au)
  • Exposure of cells to arsenite for 24 h rendered cells less responsive toward stimulation of Akt by insulin. (edu.au)
  • At the same time, short-term exposure to arsenite induced a concentration- dependent increase in phosphorylation of Akt at Ser-473, followed by phosphorylation of FoxO proteins at sites known to be phosphorylated by Akt. (edu.au)
  • Arsenite exposure resulted in attenuation of FoxO DNA binding and in nuclear exclusion of FoxO1a-EGFP. (edu.au)
  • A 24-h exposure of HepG2 cells to submicromolar concentrations of arsenite resulted in downregulation of glucose 6-phosphatase (G6Pase) and selenoprotein P (SelP) mRNA levels. (edu.au)
  • Ingestion is the main route of exposure to other arsenites and arsenates for the general population. (cdc.gov)
  • Chronic exposure to arsenite is associated with vascular disease, such as arteriosclerosis. (elsevier.com)
  • Indeed, our data indicate that arsenite exposure to stem cell-derived embryoid bodies reduces the expression of MyoD, Myf5, and myogenin, all transcription factors needed to differentiate stem cells into skeletal myocytes. (usda.gov)
  • Our preliminary data indicates that arsenite exposure only during embryogenesis reduces weight gain in offspring even 4 months later. (usda.gov)
  • In the first aim, we will determine whether exposure to low arsenite concentrations during embryogenesis reduces the number and/or localization of the satellite cells as the organism develops into an adult. (usda.gov)
  • European Standard EN 149 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced. (chemcas.com)
  • A number of different arsenite anions are known: AsO3−3 ortho-arsenite, an ion of arsenous acid, with a pyramidal shape (AsO−2)n meta-arsenite, a polymeric chain anion. (wikipedia.org)
  • Examples of these are the meta-arsenite salts and at low temperature, hydrogen arsenite salts can be prepared, such as Na2H2As4O8, NaAsO2·4H2O, Na2HAsO3·5H2O and Na5(HAsO3)(AsO3)·12H2O. (wikipedia.org)
  • Fowler's solution first introduced in the 18th century was made up from As2O3 as a solution of potassium meta-arsenite, KAsO2. (wikipedia.org)
  • This part could be used to sense different arsenite concentrations in water. (igem.org)
  • During the 19th and early 20th centuries, the most popular preparation in the Western world was called Fowler solution, which contained 1% potassium arsenite. (medscape.com)
  • In fact, so many people suffered symptoms-such as rashes, stomach distress, and headaches-from taking arsenic remedies during the Victorian era that their ailments are now sometimes referred to as " Fowler's disease ,' after the popular remedy Fowler's Solution, which contained potassium arsenite. (mentalfloss.com)
  • Some arsenite salts can be prepared from an aqueous solution of As2O3. (wikipedia.org)
  • Secondary copper mineral formed by oxidation of arsenites. (webmineral.com)
  • It's made from the PG36 phthalo green (yellow shade) pigment and PW5 white, rather than the original copper aceto-arsenite. (winsornewton.com)
  • Some species of bacteria obtain their energy by oxidizing various fuels while reducing arsenates to form arsenites. (wikipedia.org)
  • In 2008, bacteria were discovered that employ a version of photosynthesis with arsenites as electron donors, producing arsenates (just like ordinary photosynthesis uses water as electron donor, producing molecular oxygen). (wikipedia.org)
  • The arsH gene and its homologs are fundamental to confer high level of arsenite resistance in bacteria. (scialert.net)
  • Reduction of arsenate to arsenite partly accounted for the high tolerance of the bacteria to arsenate. (scielo.org.za)
  • Arsenite (As(III)) is a more toxic form of inorganic arsenic and its removal from drinking water is less effective compared with arsenate (As(V)). In the present study, synthetic birnessite ( δ -MnO 2 ) was used to investigate the oxidative transformation of arsenite into arsenate using batch experiments under different reaction conditions. (environmental-expert.com)
  • Only inorganic arsenite (iAsIII) was stable during the extraction process. (lancs.ac.uk)
  • In the metal research area, he investigates the molecular mechanism of environmental arsenite and chromium-induced toxicology and carcinogenesis with particular attention to the roles of free radicals, oxidative and nitrosative modification of zinc-finger DNA repair proteins, and zinc supplement as a chemoprevention strategy for reducing arsenic toxicity and carcinogenesis. (unm.edu)
  • Two possible processes affecting the As concentration are investigated: (1) oxidation of arsenopyrite or (2) desorption of arsenite/arsenate bound to iron hydroxides due to iron reduction. (slu.se)
  • This study aimed to explore the mechanism in detail the neuroprotection provided by CGA against arsenite-induced toxicity in mice and the underlying mechanisms involved. (edu.sa)
  • In rice (Oryza sativa), arsenite uptake shares the highly efficient silicon (Si) pathway of entry to root cells and efflux towards the xylem. (elsevier.com)
  • Hyperaccumulation appears to involve enhanced arsenate uptake, decreased arsenite-thiol complexation and arsenite efflux to the external medium, greatly enhanced xylem translocation of arsenite, and vacuolar sequestration of arsenite in fronds. (elsevier.com)
  • Functional screening and end-sequencing of large insert fosmid libraries demonstrated that arsenic(V) resistance genes were taxonomically widespread and different class of arsenic resistance genes related to periplasmic arsenate reduction, arsenite efflux, bioaccumulation (phosphate, metal transporters) and arsenite oxidation were present. (ubc.ca)
  • Arsenite methyltransferase (AS3MT) polymorphisms and arsenic methylation in children in rural Bangladesh. (cdc.gov)
  • Polymorphisms of the Arsenite Methyltransferase (As3MT) gene and urinary efficiency of arsenic metabolism in a population in northern Mexico]. (cdc.gov)
  • They also described that overexpression of OsGrx_C7 (protein found in rice) enhanced tolerance to arsenite and reduced arsenite accumulation in seeds and shoots of rice. (org.in)
  • Silicon enhances abundances of reducing microbes in rhizoplane and decreases arsenite uptake by rice (Oryza sativa L. (donga.ac.kr)
  • Note that in fields that commonly deal with groundwater chemistry, arsenite is used generically to identify soluble AsIII anions. (wikipedia.org)
  • Ortho-arsenite contrasts to the corresponding anions of the lighter members of group 15, phosphite which has the structure HPO2−3 and nitrite, NO−2 which is bent. (wikipedia.org)
  • During growth, addition of arsenate or arsenite anions adversely affected biomass production and maximum specific growth rate and, in some instances, longer lag phases were induced. (scielo.org.za)
  • Curiously, arsenite had a dual effect on SelP protein levels, inducing a small increase in the nanomolar and a distinct decrease in the micromolar concentration range. (edu.au)
  • Interestingly, arsenite-induced long-term effects on G6Pase and SelP mRNA or SelP protein levels were not blocked by the PI3K inhibitor, wortmannin. (edu.au)
  • In conclusion, arsenite perturbs cellular signaling pathways involved in fuel metabolism: it impairs cellular responsiveness toward insulin, while at the same time stimulating insulin-like signaling to attenuate the expression of genes involved in glucose metabolism and the release of the hepatokine SelP, which is known to modulate peripheral insulin sensitivity. (edu.au)
  • Concomitantly, arsenite Minimal Inhibitory Concentration (MIC), growth phase studies, antibiotic and heavy metal tolerance were tested for this strain. (scialert.net)
  • Arsenite (As +3 ) is 4-10 times as toxic as arsenate (As +5 ). (msdvetmanual.com)
  • generally arsenite (+3) is more toxic than arsenate (+5). (tjclark.com)
  • Third page of handwritten lecture notes with diagrams prepared by Louis Pasteur for a lecture to the National Academy of Medicine on the subject of crystal structures, tartaric acid, and arsenites. (sciencehistory.org)
  • Some (~20 %) of arsenate was converted into arsenite, and a significant amount (~25 %) of dimethylarsinic acid (DMAsV) was converted into monomethylarsonic acid (MMAsV) or arsenate (AsV). (lancs.ac.uk)
  • Further, reaction with periodate, arsenite and thiobarbituric acid gives a pink to red color chromophore, which is measured at 548 nm after stabilizing with DMSO. (bio-protocol.org)
  • Publicity of cells to non-haem tension inducers, including arsenite, cadmium ions, and DEM, led to the induction of HO-1 appearance, but only little changes had been proven in the creation of bilirubin (Fig. 4b,c). (bioednet.org)
  • The aim of the study was to develop arsenite resistance in Lactobacillus acidophilus and to show the presence of arsenical resistant gene in its plasmid. (scialert.net)
  • In the present study in vitro resistance against arsenite (up to 32 ppm) was developed in Lactobacillus acidophilus and the gene responsible for high level of arsenite resistance ( arsH gene) was cloned and sequenced. (scialert.net)
  • Description Distribution of 8-oxoG in (A) H2O2-treated Chlamydomonas and (B) Arsenite-treated HeLa cells. (qedbio.com)
  • RBM4 has already been shown to be involved in myogenic differentiation and it has also been shown to interact with eIF4G and eIF4A in HeLa cells while under arsenite stress, what has not been investigated is whether RBM4 interacts with eIF4G or eIF4A or other parts of the translational machinery during myogenic differentiation. (bl.uk)
  • A number of the aquaporin nodulin26-like intrinsic proteins (NIPs) are able to transport arsenite, the predominant form of As in reducing environments. (elsevier.com)
  • Chemical arsenic speciation monitoring of the enrichments suggested that arsenite oxidation and arsenate reduction occurred. (ubc.ca)
  • IUPAC have recommended that arsenite compounds are to be named as arsenate(III), for example ortho-arsenite is called trioxidoarsenate(III). (wikipedia.org)
  • The present study has demonstrated that arsenite not arsenate decreased the Fas ligand (FasL) expression on ECV304 cells through reactive oxygen species. (elsevier.com)
  • Incubation of ECV304 cells with arsenite decreased the FasL expression and increased the intracellular peroxide levels. (elsevier.com)
  • In root cells arsenate is rapidly reduced to arsenite, which is effluxed to the external medium, complexed by thiol peptides or translocated to shoots. (elsevier.com)
  • Arsenite (As(III)) is often the predominant valence state at the point of discharge but is rapidly oxidized to arsenate (As(V)) during transport in shallow surface water. (edu.sa)
  • These data suggested that arsenite initiates endothelium dysfunction, at least partly, by suppressing the FasL expression through activating reactive oxygen species sensitive endothelial cell signaling. (elsevier.com)
  • According to the results of dissolved arsenic speciation-arsenite was thé oniy species found. (journaldephysique.org)
  • The arsenite-resistant strain IITR-RKU1 showed similar growth phase patterns to that of normal parent strain in the absence or in presence of arsenite in the media. (scialert.net)
  • Stenotrophomonas maltophilia SA Ant 15 was resistant to 10 mmol l -1 arsenite and 20 mmol l -1 arsenate, whereas S. marcescens SA Ant 16 grew in 15 mmol l -1 arsenite and in up to 500 mmol l -1 arsenate, making it the most arsenic-resistant organism described to date. (scielo.org.za)
  • The mineral form of NiO (arsenite) is very rare. (iberocruceros.com)
  • In most cases arsenite should be oxidized to arsenate so that it is converted to a form more easily removed. (resintech.com)
  • In humans, arsenite inhibits pyruvate dehydrogenase (PDH complex) in the pyruvate-acetyl CoA reaction, by binding to the -SH group of lipoamide, a participant coenzyme. (wikipedia.org)
  • Atomic Absorption Spectrometric Determination of Arsenite in Water Samples by Graphite Furnace After Extraction with Ammonium sec-Butyldithiophosphate. (epa.gov)
  • Enriched media yielded two pure bacterial cultures able to grow in both arsenite and arsenate. (scielo.org.za)