Inorganic salts or organic esters of arsenious acid.
Inorganic compounds that contain sodium as an integral part of the molecule.
Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions.
Inorganic or organic salts and esters of arsenic acid.
A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
A general class of integral membrane proteins that transport ions across a membrane against an electrochemical gradient.
A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
An agent that causes the production of physical defects in the developing embryo.
Oxidoreductases that specifically reduce arsenate ion to arsenite ion. Reduction of arsenate is a critical step for its biotransformation into a form that can be transported by ARSENITE TRANSPORTING ATPASES or complexed by specific sulfhydryl-containing proteins for the purpose of detoxification (METABOLIC DETOXIFICATION, DRUG). Arsenate reductases require reducing equivalents such as GLUTAREDOXIN or AZURIN.
Inorganic or organic compounds that contain arsenic.
A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.
A schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
The type species of gram negative bacteria in the genus ALCALIGENES, found in soil. It is non-pathogenic, non-pigmented, and used for the production of amino acids.
A family in the order Chromatiales, class GAMMAPROTEOBACTERIA. These are haloalkaliphilic, phototrophic bacteria that deposit elemental sulfur outside their cells.
A plant genus of the family PTERIDACEAE. Members contain entkaurane DITERPENES. The name is similar to bracken fern (PTERIDIUM).
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
A cadmium halide in the form of colorless crystals, soluble in water, methanol, and ethanol. It is used in photography, in dyeing, and calico printing, and as a solution to precipitate sulfides. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.
A family of gram-negative bacteria in the class BETAPROTEOBACTERIA. There are at least eight genera.
The partition separating the two NASAL CAVITIES in the midplane. It is formed by the SEPTAL NASAL CARTILAGE, parts of skull bones (ETHMOID BONE; VOMER), and membranous parts.
Disorders of the choroid including hereditary choroidal diseases, neoplasms, and other abnormalities of the vascular layer of the uvea.
A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.
A chronic blistering disease with predilection for mucous membranes and less frequently the skin, and with a tendency to scarring. It is sometimes called ocular pemphigoid because of conjunctival mucous membrane involvement.
Pathological processes of the LIVER.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A parasitic hemoflagellate of the subgenus Leishmania leishmania that infects man and animals and causes visceral leishmaniasis (LEISHMANIASIS, VISCERAL). The sandfly genera Phlebotomus and Lutzomyia are the vectors.
Substances that are destructive to protozoans.
A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.
A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi.
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
A group of AROMATIC HYDROCARBONS that have three rings joined as a triad around a single carbon atom so all three are conjoined, in contrast to a linear arrangement (ANTHRACENES) or angular arrangement (PHENANTHRENES).
An enzyme that catalyzes the formation of asparagine from ammonia and aspartic acid, in the presence of ATP. EC 6.3.1.1.
A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.
Collections of illustrative plates, charts, etc., usually with explanatory captions.
The epithelial lining of the URINARY TRACT.
A water insoluble terpene fatty acid used in the treatment of gastrointestinal ulcers; it facilitates the healing and function of mucosal tissue.
Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.
Tumors or cancer of the URINARY BLADDER.
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.

Overexpression of the multidrug resistance-associated protein (MRP1) in human heavy metal-selected tumor cells. (1/791)

Cellular and molecular mechanisms involved in the resistance to cytotoxic heavy metals remain largely to be characterized in mammalian cells. To this end, we have analyzed a metal-resistant variant of the human lung cancer GLC4 cell line that we have selected by a step-wise procedure in potassium antimony tartrate. Antimony-selected cells, termed GLC4/Sb30 cells, poorly accumulated antimony through an enhanced cellular efflux of metal, thus suggesting up-regulation of a membrane export system in these cells. Indeed, GLC4/Sb30 cells were found to display a functional overexpression of the multidrug resistance-associated protein MRP1, a drug export pump, as demonstrated by Western blotting, reverse transcriptase-polymerase chain reaction and calcein accumulation assays. Moreover, MK571, a potent inhibitor of MRP1 activity, was found to markedly down-modulate resistance of GLC4/Sb30 cells to antimony and to decrease cellular export of the metal. Taken together, our data support the conclusion that overexpression of functional MRP1 likely represents one major mechanism by which human cells can escape the cytotoxic effects of heavy metals.  (+info)

Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. (2/791)

Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistant sublines of Chinese hamster V79 cells have now been isolated. In order to gain understanding of possible targets for arsenite's action, one arsenite-resistant subline, As/R28A, was chosen as a donor for a cDNA expression library. The library from arsenite-induced As/R28A cells was transfected into arsenite-sensitive As/S5 cells, and transfectants were selected for arsenite-resistance. Two cDNAs, asr1 and asr2, which confer arsenite resistance to arsenite-hypersensitive As/S5 cells as well as to wild-type cells, were isolated. asr1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin-like region fused to S30 ribosomal protein. Arsenite was previously shown to inhibit ubiquitin-dependent proteolysis. These results suggest that the tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite.  (+info)

Protein-damaging stresses activate c-Jun N-terminal kinase via inhibition of its dephosphorylation: a novel pathway controlled by HSP72. (3/791)

Various stresses activate the c-Jun N-terminal kinase (JNK), which is involved in the regulation of many aspects of cellular physiology, including apoptosis. Here we demonstrate that in contrast to UV irradiation, heat shock causes little or no stimulation of the JNK-activating kinase SEK1, while knocking out the SEK1 gene completely blocks heat-induced JNK activation. Therefore, we tested whether heat shock activates JNK via inhibition of JNK dephosphorylation. The rate of JNK dephosphorylation in unstimulated cells was high, and exposure to UV irradiation, osmotic shock, interleukin-1, or anisomycin did not affect this process. Conversely, exposure of cells to heat shock and other protein-damaging conditions, including ethanol, arsenite, and oxidative stress, strongly reduced the rate of JNK dephosphorylation. Under these conditions, we did not observe any effects on dephosphorylation of the homologous p38 kinase, suggesting that suppression of dephosphorylation is specific to JNK. Together, these data indicate that activation of JNK by protein-damaging treatments is mediated primarily by inhibition of a JNK phosphatase(s). Elevation of cellular levels of the major heat shock protein Hsp72 inhibited a repression of JNK dephosphorylation by these stressful treatments, which explains recent reports of the suppression of JNK activation by Hsp72.  (+info)

Complexes containing activating transcription factor (ATF)/cAMP-responsive-element-binding protein (CREB) interact with the CCAAT/enhancer-binding protein (C/EBP)-ATF composite site to regulate Gadd153 expression during the stress response. (4/791)

Gadd153, also known as chop, encodes a member of the CCAAT/enhancer-binding protein (C/EBP) transcription factor family and is transcriptionally activated by cellular stress signals. We recently demonstrated that arsenite treatment of rat pheochromocytoma PC12 cells results in the biphasic induction of Gadd153 mRNA expression, controlled in part through binding of C/EBPbeta and two uncharacterized protein complexes to the C/EBP-ATF (activating transcription factor) composite site in the Gadd153 promoter. In this report, we identified components of these additional complexes as two ATF/CREB (cAMP-responsive-element-binding protein) transcription factors having differential binding activities dependent upon the time of arsenite exposure. During arsenite treatment of PC12 cells, we observed enhanced binding of ATF4 to the C/EBP-ATF site at 2 h as Gadd153 mRNA levels increased, and enhanced binding of ATF3 complexes at 6 h as Gadd153 expression declined. We further demonstrated that ATF4 activates, while ATF3 represses, Gadd153 promoter activity through the C/EBP-ATF site. ATF3 also repressed ATF4-mediated transactivation and arsenite-induced activation of the Gadd153 promoter. Our results suggest that numerous members of the ATF/CREB family are involved in the cellular stress response, and that regulation of stress-induced biphasic Gadd153 expression in PC12 cells involves the ordered, sequential binding of multiple transcription factor complexes to the C/EBP-ATF composite site.  (+info)

Teratogen-induced cell death in postimplantation mouse embryos: differential tissue sensitivity and hallmarks of apoptosis. (5/791)

Teratogen-induced cell death is a common event in the pathogenesis associated with tissues destined to be malformed. Although the importance of this cell death is recognized, little information is available concerning the biochemistry of teratogen-induced cell death. We show that three teratogens, hyperthermia, cyclophosphamide and sodium arsenite induce an increase in cell death in day 9.0 mouse embryos with concurrent induction of DNA fragmentation, activation of caspase-3 and the cleavage of poly (ADP-ribose) polymerase (PARP). Teratogen-induced cell death is also selective, i. e., some cells within a tissue die while others survive. In addition, cells within some tissues die when exposed to teratogens while cells in other tissues are relatively resistant to teratogen-induced cell death. An example of the latter selectivity is seen in the cells of the developing heart, which are resistant to the cytotoxic potential of many teratogens. We show that the absence of cell death in the heart is accompanied by the complete lack of DNA fragmentation, activtion of caspase-3 and the cleavage of PARP.  (+info)

Pathways of As(III) detoxification in Saccharomyces cerevisiae. (6/791)

Saccharomyces cerevisiae has two independent transport systems for the removal of arsenite from the cytosol. Acr3p is a plasma membrane transporter that confers resistance to arsenite, presumably by arsenite extrusion from the cells. Ycf1p, a member of the ABC transporter superfamily, catalyzes the ATP-driven uptake of As(III) into the vacuole, also producing resistance to arsenite. Vacuolar accumulation requires a reductant such as glutathione, suggesting that the substrate is the glutathione conjugate, As(GS)3. Disruption of either the ACR3 or YCF1 gene results in sensitivity to arsenite and disruption of both genes produces additive hypersensitivity. Thus, Acr3p and Ycf1p represent separate pathways for the detoxification of arsenite in yeast.  (+info)

Sodium arsenite enhances copper accumulation in human lung adenocarcinoma cells. (7/791)

In this report, we found that arsenite-resistant human lung adenocarcinoma cells, CL3R15, were more susceptible to CuCl2 than the parental CL3 cells. With the aid of atomic absorption spectrophotometry, we observed that CL3R15 cells accumulated more copper than CL3 cells. We further demonstrated that sodium arsenite treatment resulted in a dose-dependent increase of copper accumulation in the parental CL3 cells. In contrast, copper did not alter the levels of intracellular arsenite in CL3 cells treated in combination with sodium arsenite and CuCl2. Pretreatment of CL3 cells with sodium arsenite resulted in a significant increase of copper accumulation and cytotoxicity. These results indicate that intracellular copper accumulation is enhanced by arsenite. However, arsenite-enhanced copper accumulation was not observed in two fibroblastic cells, GM00220 and GM03700, derived from Menkes patients. The Menkes gene encodes a membrane pump responsible for copper exportation. Our results suggest that Menkes protein is a potential target of arsenite.  (+info)

Asp45 is a Mg2+ ligand in the ArsA ATPase. (8/791)

The ATPase activity of ArsA, the catalytic subunit of the plasmid-encoded, ATP-dependent extrusion pump for arsenicals and antimonials in Escherichia coli, is allosterically activated by arsenite or antimonite. Magnesium is essential for ATPase activity. To examine the role of Asp45, mutants were constructed in which Asp45 was changed to Glu, Asn, or Ala. Cells expressing these mutated arsA genes lost arsenite resistance to varying degrees. Purified D45A and D45N enzymes were inactive. The purified D45E enzyme exhibited approximately 5% of the wild type activity with about a 5-fold decrease in affinity for Mg2+. Intrinsic tryptophan fluorescence was used to probe Mg2+ binding. ArsA containing only Trp159 exhibited fluorescence enhancement upon the addition of MgATP, which was absent in D45N and D45A. As another measure of conformation, limited trypsin digestion was used to estimate the surface accessibility of residues in ArsA. ATP and Sb(III) synergistically protected wild type ArsA from trypsin digestion. Subsequent addition of Mg2+ increased trypsin sensitivity. D45N and D45A remained protected by ATP and Sb(III) but lost the Mg2+ effect. D45E exhibited an intermediate Mg2+ response. These results indicate that Asp45 is a Mg2+-responsive residue, consistent with its function as a Mg2+ ligand.  (+info)

Sodium arsenite exposure at concentration >5 M may induce embryotoxic and teratogenic effects in animal models. several downstream focuses on that control cell survival and apoptosis. Furthermore, the whole core transcription element circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, April4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 M) exposure. This was adopted by G2/M police arrest and induction of the mitochondrial apoptotic pathway that might become suppressed by caspase-9 and caspase-3 inhibitors. In contrast to mouse ESC D-(+)-Xylose supplier with very low endogenous IL6, mouse neural come/precursor cells (C17.2 clone immortalized by and and [18, 19]; and [20]; and [21], which could induce reprogramming fibroblasts to pluripotency. The triumvirate D-(+)-Xylose supplier of transcription factors April4, Nanog and Sox2 takes on the fundamental part in gene regulations, frequently presenting multiple localised sites in the regulatory locations of the ...
DOSE DEPENDENT EFFECTS OF SODIUM ARSENITE ON NF-kB AND INTERLEUKIN-8 IN BRONCHIAL EPITHELIAL CELLS A Thesis Submitted to the Faculty In partial fulfillment of the requirements for the degree of Doctor of Philosophy in Pharmacology and Toxicology by Robert Ronald Roussel DARTMOUTH COLLEGE Hanover, New Hampshire July 31, 2000 Reproduced with permission of the copyright owner. Further reproduction prohibited without permission ...
TY - JOUR. T1 - Arsenite exposure in human lymphoblastoid cell lines induces autophagy and coordinated induction of lysosomal genes. AU - Bolt, Alicia M.. AU - Douglas, Randi M.. AU - Klimecki, Walter T.. PY - 2010/11/30. Y1 - 2010/11/30. N2 - Chronic exposure to inorganic arsenic is associated with diverse, complex diseases, making the identification of the mechanism underlying arsenic-induced toxicity a challenge. An increasing body of literature from epidemiological and in vitro studies has demonstrated that arsenic is an immunotoxicant, but the mechanism driving arsenic-induced immunotoxicity is not well established. We have previously demonstrated that in human lymphoblastoid cell lines (LCLs), arsenic-induced cell death is strongly associated with the induction of autophagy. In this study we utilized genome-wide gene expression analysis and functional assays to characterize arsenic-induced effects in seven LCLs that were exposed to an environmentally relevant, minimally cytotoxic, ...
Arsenic can induce reactive oxygen species (ROS) leading to oxidative stress and carcinogenesis. Bladder is one of the major target organs of arsenic, and cyclooxygenase-2 (COX-2) may play an important role in arsenic-induced bladder cancer. However, the mechanism by which arsenic induces COX-2 in bladder cells remains unclear. This study aimed at investigating arsenic-mediated intracellular redox status and signaling cascades leading to COX-2 induction in human uroepithelial cells (SV-HUC-1). SV-HUC-1 cells were exposed to sodium arsenite and COX-2 expression, mitogen-activated protein kinase (MAPK) phosphorylation, glutathione (GSH) levels, ROS induction and Nrf2 expression were quantified. Our results demonstrate that arsenite (1-10 μM) elevates COX-2 expression, GSH levels, ROS and Nrf2 expression. Arsenite treatment for 24h stimulates phosphorylation of ERK and p38, but not JNK in SV-HUC-1 cells. Induction of Cox-2 mRNA levels by arsenite was attenuated by inhibitors of ERK, p38 and JNK. Arsenite
Arsenite has long been known as a human carcinogen. The hypoxia-inducible factor-1 (HIF-1) is an important transcription factor upon hypoxia and other stresses, which is proved to be associated with the pathogenesis of several cancers. Although hypoxia-inducible factor-1α (HIF-1α) has been reported to be activated by arsenite both in vivo and in vitro, the detailed molecular mechanisms leading to HIF-1α expression and activation due to arsenite exposure have not been well understood. In the present study, we found that arsenite is able to induce HIF-1α protein accumulation in both mouse epidermal Cl41 cells and mouse embryonic fibroblasts (MEFs). Knockout of p85α in MEFs (p85α−/−) led to the deficiency of HIF-1α protein accumulation induced by arsenite exposure, suggesting that p85α is crucial for arsenite-induced stabilization of HIF-1α protein. At the same time, our studies also show that p85a exhibited an inhibition of HIF-1α protein degradation via PI-3K/Akt-dependent pathway ...
Epidemiology studies have established a strong link between lung cancer and arsenic exposure. Currently, the role of disturbed cellular energy metabolism in carcinogenesis is a focus of scientific interest. Hypoxia inducible factor-1 alpha (HIF-1A) is a key regulator of energy metabolism, and it has been found to accumulate during arsenite exposure under oxygen-replete conditions. We modeled arsenic-exposed human pulmonary epithelial cells in vitro with BEAS-2B, a non-malignant lung epithelial cell line. Constant exposure to 1 µM arsenite (As) resulted in the early loss of anchorage-dependent growth, measured by soft agar colony formation, beginning at 6 weeks of exposure. This arsenite exposure resulted in HIF-1A accumulation and increased glycolysis, similar to the physiologic response to hypoxia, but in this case under oxygen-replete conditions. This
Results: Plasma membrane (p< 0.001) and acrosome integrity (p< 0.05) of the spermatozoa were significantly reduced in sodium arsenite group compared to the control. In silymarin + sodium arsenite group, silymarin was able to significantly (p< 0.001) ameliorate the adverse effects of sodium arsenite on these sperm parameters compared to sodium arsenite group. The incubation of sperm for 180 min (control group) showed a significant (p< 0.001) decrease in acrosome integrity compared to the spermatozoa at 0 hour. The application of silymarin alone for 180 min could also significantly (p< 0.05) increase sperm acrosome integrity compared to the control ...
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The down-flow hanging sponge (DHS) reactor was used for continuous As removal treatment of As-contaminated water. The treatment scheme was: 1) As(III) in contaminated water is oxidized by arsenite-oxidizing bacteria fixed in the sponges in the reactor; 2) Fe(II) naturally existing in water is oxidized by dissolved oxygen; 3) Fe(III) is precipitated as iron hydroxide and As(V) is co-precipitated with the iron hydroxide; and finally 4) the co-precipitates are fixed in the sponges. This system could remove As from As-contaminated water on a small scale and at low cost. The results showed that, after using the DHS reactor, As and Fe concentrations in the treated water were lower than water quality standards for drinking water when Fe(II) concentration in influent was lower than 10 mg/L and the Fe/As ratio was higher than 6.67-8.42, with dependence on the Fe concentration. Additionally, even if Fe concentration is higher than 10 mg/L, the treatment system is still applicable if pH of the influent is ...
Sigma-Aldrich offers abstracts and full-text articles by [Chien-Te Chou, Hong-Ting Lin, Pai-An Hwang, Shang-Ta Wang, Cheng-Hong Hsieh, Deng-Fwu Hwang].
for toxicological evaluation and was selected for immunotoxicity studies by the chemical manager. The purpose of the range-finding study was to determine the doses of sodium arsenite to be used in an immuntoxicology protocol.. The range-finding studies were conducted in female B6C3F1 mice. The animals were administered sodium arsenite as a pellet implanted subcutaneously. The sodium-meta arsenite was purchased from Sigma Chemical Company and pelletized by Innovative Research of America. The pellets were prepared using 1, 3 and 6 mg/pellet as recommended by the producer to obtain the desired blood levels of 100, 300 and 600 ng/ml. These doses proved highly toxic and the pellets were then prepared at 0.01, 0.03 and 0.06 mg/pellet. Two studies were carried out in completing the range-finding protocol. The pellets were implanted on day 1 and the assay evaluations were performed on day 15. Dose levels of 0.01, 0.03 and 0.06 mg/pellet were used; however, the high dose of 0.06 mg/pellet resulted in the ...
23594 : Genome-wide DNA methylation analysis of sperm to explore the mechanism of hepatic tumor augmentation in the F2 by gestational arsenite exposure of F0 pregnant ...
To examine the hypothesis that induction of heat shock proteins by a nonthermal mechanism would confer protection against experimental sepsis.Prospective, blind, randomiz
Theres an article from 2004 about a vet who treated falcons diagnosed with CFS with Potassium Arsenite 0.05% leading to complete remission of symptoms...
S cerevisiae ACR3 protein: ACR - Arsenic Compounds Resistance; a putative membrane protein involved in Arsenite transport; has been sequenced
To evaluate the capacity of the S130P mutant protein to bind PKR, mobile lysates from WT or S130P FLAG-RAX expressing L929 cells treated with sodium arsenite
Heme oxygenase-1 is an inducible enzyme that catalyzes heme degradation and has been proposed to play a role in protecting cells against oxidative stress-related injury. We investigated the induction of heme oxygenase-1 by the tumor promoter arsenite in a chicken hepatoma cell line, LMH. We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in response to sodium arsenite treatment. This construct was used to investigate the role of mitogen-activated protein (MAP) kinases in arsenite-mediated heme oxygenase-1 gene expression. In LMH cells, sodium arsenite, cadmium, and heat shock, but not heme, induced activity of the MAP kinases extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. To examine whether these MAP kinases were involved in mediating heme oxygenase-1 gene expression, we utilized constitutively activated and dominant negative components of the ERK, JNK, and p38 MAP kinase signaling pathways. Involvement
TY - JOUR. T1 - Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite. AU - Keyse, Stephen M.. AU - Tyrrell, Rex M.. PY - 1989. Y1 - 1989. N2 - We have shown that UVA (320-380 nm) radiation, hydrogen peroxide, and sodium arsenite induce a stress protein of approximately 32 kDa in human skin fibroblasts. The synthesis and cloning of cDNA from arsenite-induced mRNA populations have now allowed us to unequivocally identify the 32-kDa protein as heme oxygenase. By mRNA analysis we have shown that the heme oxygenase gene is also induced in cultured human skin fibroblasts by UVA radiation, hydrogen peroxide, cadmium chloride, iodoacetamide, and menadione. The known antioxidant properties of heme catabolites taken together with the observation of a high level of induction of the enzyme in cells from an organ not involved in hemoglobin breakdown strongly supports the proposal that the induction of heme oxygenase may ...
TY - JOUR. T1 - Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines. AU - Bolt, Alicia M.. AU - Byrd, Randi M.. AU - Klimecki, Walter T.. PY - 2010/5/1. Y1 - 2010/5/1. N2 - Arsenic is a widespread environmental toxicant with a diverse array of molecular targets and associated diseases, making the identification of the critical mechanisms and pathways of arsenic-induced cytotoxicity a challenge. In a variety of experimental models, over a range of arsenic exposure levels, apoptosis is a commonly identified arsenic-induced cytotoxic pathway. Human lymphoblastoid cell lines (LCL) have been used as a model system in arsenic toxicology for many years, but the exact mechanism of arsenic-induced cytotoxicity in LCL is still unknown. We investigated the cytotoxicity of sodium arsenite in LCL 18564 using a set of complementary markers for cell death pathways. Markers indicative of apoptosis (phosphatidylserine externalization, PARP cleavage, and sensitivity to ...
One of the key mediators of the antiviral and antiproliferative actions of interferon is double-stranded-RNA-dependent protein kinase (PKR). PKR activity is also involved in the regulation of cell proliferation, apoptosis and signal transduction. We have recently identified PACT, a novel protein activator of PKR, as an important modulator of PKR activity in cells in the absence of viral infection. PACT heterodimerizes with PKR and activates it by direct protein-protein interactions. Endogenous PACT acts as an activator of PKR in response to diverse stress signals, such as serum starvation and peroxide or arsenite treatment, and is therefore a novel, stress-modulated physiological activator of PKR. In this study, we have characterized the functional domains of PACT that are required for PKR activation. Our results have shown that, unlike the N-terminal conserved domains 1 and 2, the third conserved domain of PACT is dispensable for its binding of double-stranded RNA and inter action with PKR. ...
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This thesis is centered on the paper, Chronic Low-Level Arsenite Exposure through Drinking Water Increases Blood Pressure and Promotes Concentric Left Ventricular Hypertrophy in Female Mice. It was published in Toxicological Pathology on January 3, 2012 and represents a culmination of work done by Pablo Sanchez-Soria, Derrick Broka, Dr. Todd D. Camenisch, and myself (Sarah Lian Monks). My research, contribution, and specific participation are noted and precede the article, which was a culmination of work done over approximately a year and a half. Pablo Sanchez-Soria is a graduate student in the Department of Pharmacology and Toxicology and the primary author I worked under. The key results of the paper show arsenic induced left ventricular hypertrophy, and elevated systolic and diastolic blood pressure in exposed mice. ...
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
Selected Publications Hur, H. and Reeder, R.J. (2016) Tungstate sorption mechanisms on boehmite: Systematic uptake studies and X-ray absorption spectroscopy analysis. J. Colloid. Interface Sci., 461, 249-260.. Sklute, E.C., Jensen, H.B., Rogers, A.D., Reeder, R.J. (2015) Morphological, structural, and spectral characteristics of amorphous iron sulfates, J. Geophys. Res. Planets, 120, 809-830.. Cerkez, E.B., Bhandari, N., Reeder, R.J., and Strongin, D.R. (2015) Coupled redox transformation of chromate and arsenite on ferrihydrite. Environ. Sci. Tech., 49, 2858-2866.. Szema, A.M., Reeder, R.J., Harrington, A.D., Schmidt, M., Liu, J., Golightly, M., Rueb, T., Hamidi, S.A., (2014) Iraq dust is respirable, sharp, and metal-laden and induces lung inflammation with fibrosis in mice via IL-2 upregulation and depletion of regulatory T cells. J. Occup. Environ. Med., 56, 243-251. Schmidt, M.P., Ilott, A.J., Phillips, B.L., and Reeder, R.J. (2014) Structural changes upon dehydration of amorphous calcium ...
Quanto tempo dura o efeito do viagra 50mg - Inquire about the care needed when possible. Also, pharmacologic therapy with sodium arsenite and lewisite demonstrate that when food enters it.
Sigma-Aldrich offers abstracts and full-text articles by [Huan Xu, Xixi Zhou, Xia Wen, Fredine T Lauer, Ke Jian Liu, Laurie G Hudson, Lauren M Aleksunes, Scott W Burchiel].
When confronted with environmental stress, cells either activate defence mechanisms to survive, or initiate apoptosis, depending on the type of stress. Certain types of stress, such as hypoxia, heatshock and arsenite (type 1 stress), induce cells to assemble cytoplasmic stress granules (SGs), a majo …
English: Soil and water sites were sampled at a South African antimony mine with elevated levels of arsenic due to the refining process. Enriched media yielded six pure bacterial cultures able to grow in both arsenite and ...
Chemical genetics in yeast has shown great potential for clarifying the pharmacology of various drugs. Investigating these results from a systems perspective has uncovered many facets of natural chemical tolerance, but many cellular interactions of chemicals still remain poorly understood. To uncover previou
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TY - JOUR. T1 - Decreasing arsenic accumulation in rice by overexpressing OsNIP1;1 and OsNIP3;3 through disrupting arsenite radial transport in roots. AU - Sun, Sheng Kai. AU - Chen, Yi. AU - Che, Jing. AU - Konishi, Noriyuki. AU - Tang, Zhong. AU - Miller, Anthony J.. AU - Ma, Jian Feng. AU - Zhao, Fang Jie. N1 - Funding Information: The work was supported by the Natural Science Foundation of China (31520103914), the Ministry of Science and Technology Key R&D program (2016YFD0100704), the special fund for agro-scientific research in the public interest (201403015), the Innovative Research Team Development Plan of the Ministry of Education of China (Grant no. IRT_17R56), the Fundamental Research Funds for the Central Universities and by Grant-in-Aid for Specially Promoted Research (JSPS KAKENHI Grant no. 16H06296 to J.F.M.). Y.C. and A.J.M. were funded by the UK Biotechnological and Biological Sciences Research Council (BBSRC) Institute Strategic Programme Grant Molecules from Nature ...
TY - JOUR. T1 - Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. AU - Keyse, Stephen M.. AU - Tyrrell, Rex M.. PY - 1987/10/25. Y1 - 1987/10/25. N2 - We have analyzed the pattern of protein synthesis in solar near ultraviolet (334 nm, 365 nm) and near visible (405 nm) irradiated normal human skin fibroblasts. Two hours after irradiation we find that one major stress protein of approximately 32 kDa is induced in irradiated cells. This protein is not induced by ultraviolet radiation at wavelengths shorter than 334 nm and is not inducible by heat shock treatment of these cells. Although sodium arsenite, diamide, and menadione all induced a 32-kDa protein, they also induced the major heat shock proteins. In contrast, the oxidizing agent, hydrogen peroxide, induced the low molecular weight stress protein without causing induction of the major heat shock proteins. A comparison of the 32-kDa proteins induced by ...
Resistance to arsenite (As(III)) by cells is generally accomplished by arsenite efflux permeases from Acr3 or ArsB unrelated families. We analyzed the function of three Acr3 proteins from Corynebacterium glutamicum, CgAcr3-1, CgAcr3-2, and CgAcr3-3. CgAcr3-1 conferred the highest level of As(III) resistance and accumulation in vivo. CgAcr3-1 was also the most active when everted membranes vesicles from Escherichia coli or C. glutamicum mutants were assayed for efflux with different energy sources. As(III) and antimonite (Sb(III)) resistance and accumulation studies using E. coli or C. glutamicum arsenite permease mutants clearly show that CgAcr3-1 is specific for As(III). In everted membrane vesicles expressing CgAcr3-1, dissipation of either the membrane potential or the pH gradient of the proton motive force did not prevent As(III) uptake, whereas dissipation of both components eliminated uptake. Further, a mutagenesis study of CgAcr3-1 suggested that a conserved cysteine and glutamate are ...
1. A hypothesis is given concerning the action of urethan and arsenite on malignant growth. Two assumptionsares made:- (a) the enzyme system responsible for energy production in malignant tumours is working at maximal rate, contrary to the corresponding enzyme system in normal tissues. (b) a given concentration of urethan or ... read more arsenite blocks an equal part of the sensitive enzyme(s), by which a measurable effect of a small concentration of these inhibitors on the catabolism will only be obtained in case of maximal turnover rate. 2. Experiments with kidney and liver minces and with yeast have shown that indeed the inhibition caused by urethan and arsenite increases with increasing rate of respiration or fermentation. 3. If the enzyme concentration is not considered to be negligible as compared to the substrate concentration, as is done in the theory of and , the increase of inhibition with increasing turnover number can be made plausible by enzyme kinetics for the much simplified case ...
Mesoporous pellet adsorbent developed from mixing at an appropriate ratio of natural clay, iron oxide, iron powder, and rice bran was used to investigate the optimization process of batch adsorption parameters for treating aqueous solution coexisting with arsenate and arsenite. Central composite design under response surface methodology was applied for optimizing and observing both individual and interactive effects of four main influential adsorption factors such as contact time (24-72 h), initial solution pH (3-11), adsorbent dosage (0-20 g/L) and initial adsorbate concentration (0.25-4.25 mg/L). Analysis of variance suggested that experimental data were better fitted by the quadratic model with the values of regression coefficient and adjusted regression coefficient higher than 95%. The model accuracy was supported by the correlation plot of actual and predicted adsorption efficiency data and the residual plots. The Pareto analysis suggested that initial solution pH, initial adsorbate concentration,
Fowler , P A , Drake , A J , OShaughnessy , P J , Bhattacharya , S , Raab , A , Sinclair , K D , Feldmann , J & Meharg , A A 2016 , Comment on Effects of Arsenite during Fetal Development on Energy Metabolism and Susceptibility to Diet-Induced Fatty Liver Diseases in Male Mice and Mechanisms Underlying Latent Disease Risk Associated with Early-Life Arsenic Exposure: Current Trends and Scientific Gaps Environmental Health Perspectives , vol 124 , no. 6 , pp. A99-A99 . DOI: 10.1289/ehp. ...
Abstract: Antioxidant Actions of Dried Flower Extracts of Hibiscus sabdariffa L. On Sodium Arsenite - Induced Oxidative Stress in Rats
Influential parameters to produce iron-coated ZSM-5 zeolite including iron loading concentration, calcination temperature and time, synthesis temperature and mixing intensity were investigated. Results showed that the optimized iron-coated ZSM-5 nano-adsorbent is produced if 40 wt.% iron loading concentration at 30 °C synthesis temperature under 60 rpm mixing intensity and 400 °C calcination temperature for 3 hrs are applied. Also, optimization of some parameters such as pH, adsorbent dose, contact time and temperature for removal of arsenite from aqueous solution with 400 μg/L initial concentration was considered. Evidently, the highest adsorption of arsenite occurred under pH 7, adsorbent dose 2.5 g/L, contact time 30 min and temperature 40 °C. Kinetic and isotherm models studied showed that arsenite adsorption by iron-coated ZSM-5 follows pseudo-third order equation and well fitted with Langmuir isotherm model. Evaluation showed that the optimized iron-coated ZSM-5 zeolite is able to ...
Learn more about Chemical Stress Test at Reston Hospital Center DefinitionReasons for TestPossible ComplicationsWhat to ExpectCall Your Doctorrevision ...
When cells are subjected to stress, such as heat shock, genes associated with growth are downregulated and expression of proteins believed to increase cellular survival, such as HSP70, are selectively upregulated. In eukaryotes, this regulation operates at multiple levels: transcription initiation may be enhanced via factors specific for heat shock-genes, whereas for other genes there is selective inhibition of splicing and nuclear export of mRNAs (Bond, 2006).. Stress also influences the fate of cytoplasmic mRNA in eukaryotes. Treatment of mammalian cells with a variety of stresses, such as arsenite or heat shock, results in the relocation of most mRNAs from polysomes to cytoplasmic foci called stress granules (Kedersha et al., 1999). These contain the small ribosomal subunit (Kedersha et al., 2002), the translation-initiation factors eIF2, eIF3, eIF4E and eIF4G (Kedersha et al., 2002; Kimball et al., 2003), the poly(A)-binding protein (Kedersha et al., 1999), DHH1 (also known as DDX6, Rck, ...
This picture was taken by me a long time ago (6 years, i think). Contrary to the name of the blog, this is not GFP. To take this picture, I performed Immunofluorescence experiment. The procedure is as follows: Cells are treated with whatever you are invetigating (in this case - cells were treated with 0.5mM arsenite…
The influence of ethylenediaminetetraacetic acid (EDTA) and chemical species on arsenic accumulation in aquatic floating macrophyte Spirodela polyrhiza L. (duckweed) was investigated. The uptake of inorganic arsenic species (arsenate; As(V) and arsenite; As(III)) into the plant tissue and their adsorption on iron plaque of plant surfaces were significantly (p,0.05) higher than those of organic species (monomethylarsonic acid (MMAA) and dimethylarsinic acid (DMAA)). The addition of EDTA to the culture media increased the uptake of As(V) and As(III) into the plant tissue though the MMAA and DMAA uptake were not affected. About 46% of the inorganic arsenic species were desorbed or mobilized from iron plaque by EDTA. Desorption of organic arsenic species was not affected by EDTA addition because the co-precipitation occurs only with inorganic species. Phosphate uptake was not affected by EDTA though its concentration in citrate-bicarbonate-EDTA (CBE)-extract was much higher than that of plant ...
In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and glutaredoxin 1 (Grx1). The three ligands must be present simultaneously for reduction to occur. ArsA and ArsB form an anion-translocating ATPase. The ArsB protein is distinguished by its overall hydrophobic ...
RNA helicases are vital components of various pathways for post-transcriptional gene regulation. TgHoDI is a newly identified member of the DEAD-box RNA helicase family in Toxoplasma gondii. This study was aimed at characterizing the function of TgHoDI in post-transcriptional regulation during various stages of the parasite life cycle. Through immunofluorescence analyses, TgHoDI was found to colocalize with mRNA aggregates in cytoplasmic foci. Furthermore, colocalization studies of TgHoDI with PABPC3 identified these proteins as components of RNA aggregates known as stress granules. Cycloheximide and arsenite treatment of extracellular parasites revealed the presence of mechanisms involved in the determination of mRNA fate in Toxoplasma. Also, TgHoDI was found to functionally compliment the temperature sensitive phenotype in Δdhh1 yeast, validating its role in stress response. These findings confirm that TgHoDI is a vital component in the formation of stress granules and possibly involved in the
Base excision repair (BER) is crucial for development and for the repair of endogenous DNA damage. However, unlike nucleotide excision repair, the regulation of BER is not well understood. Arsenic, a well-established human carcinogen, is known to produce oxidative DNA damage, which is repaired primarily by BER, while high doses of arsenic can also inhibit DNA repair. However, the mechanism of repair inhibition by arsenic and the steps inhibited are not well defined. To address this question we have investigated the regulation of DNA polymerase β (Pol β) and AP endonuclease (APE1), in response to low, physiologically relevant doses of arsenic. GM847 lung fibroblasts and HaCaT keratinocytes were exposed to sodium arsenite, As(III), and mRNA, protein levels and BER activity were assessed. Both Pol β and APE1 mRNA exhibited significant dose-dependant down regulation at doses of As(III) above 1 µM. However, at lower doses Pol β mRNA and protein levels, and consequently, BER activity were ...
According to recent reports, millions of people across the globe are suffering from arsenic (As) toxicity. Arsenic is present in different oxidative states in the environment and enters in the food chain through soil and water. In the agricultural field, irrigation with arsenic contaminated water, that is, having a higher level of arsenic contamination on the top soil, which may affects the quality of crop production. The major crop like rice (Oryza sativa L.) requires a considerable amount of water to complete its lifecycle. Rice plants potentially accumulate arsenic, particularly inorganic arsenic (iAs) from the field, in different body parts including grains. Different transporters have been reported in assisting the accumulation of arsenic in plant cells; for example, arsenate (AsV) is absorbed with the help of phosphate transporters, and arsenite (AsIII) through nodulin 26-like intrinsic protein (NIP) by the silicon transport pathway and plasma membrane intrinsic protein aquaporins. Researchers and
Background: The family of c-Jun NH2-terminal kinases (JNK) plays important roles in embryonic development and in cellular responses to stress. Toxic metals and their compounds are potent activators of JNK in mammalian cells. The mechanism of mammalian JNK activation by cadmium and sodium arsenite involves toxicant-induced oxidative stress. The study of mammalian signaling pathways to JNK is complicated by the significant degree of redundancy among upstream JNK regulators, especially at the level of JNK kinase kinases (JNKKK). Results: Using Drosophila melanogaster S2 cells, we demonstrate here that cadmium and arsenite activate Drosophila JNK (D-JNK) via oxidative stress as well, thus providing a simpler model system to study JNK signaling. To elucidate the signaling pathways that lead to activation of D-JNK in response to cadmium or arsenite, we employed RNA interference (RNAi) to knock down thirteen upstream regulators of D-JNK, either singly or in combinations of up to seven at a time. Conclusion: D
Information about the open-access article Arsenic accumulation in rice: Consequences of rice genotypes and management practices to reduce human health risk in DOAJ. DOAJ is an online directory that indexes and provides access to quality open access, peer-reviewed journals.
I was told that someone could die of arsenic toxicity from eating a lot of shrimps/prawns. Im sure a lot means A LOT. Could you explain how this could happen and what happens in the system, and how to avoid/cure it? Thanl you ...
The substance may have effects on the skin, mucous membranes, bone marrow, blood, central nervous system, peripheral nervous system and liver. This may result in pigmentation disorders, perforation of the nasal septum, anaemia, nervous system impairment and liver impairment. This substance is carcinogenic to humans. Causes toxicity to human reproduction or development ...
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
2000, describes a method for removing arsenic from fly ash, in which arsenic is recovered as scorodite. The first treatment stage of the arsenic-containing material is the oxidation of trivalent arsenic (As(lll)) into pentavalent arsenic (As(V)) with a gas containing sulphur dioxide and oxygen in oxidising conditions, in which arsenic does not precipitate. After this, arsenic is precipitated in atmospheric conditions, in which the Fe(III)/As(V) mole ratio is specified as 1. Precipitation is carried out either in one or several stages, but precipitation as scorodite demands the over-saturation of the solution, which is achieved by recycling scorodite crystals to the first precipitation reactors and simultaneously neutralising the suspension. A beneficial pH range is around 1-2 and this is maintained by feeding a suitable neutralising agent into the precipitation stage. In these conditions, arsenic can be precipitated to the level of 0.5 g/l. The final arsenic removal to a level below 0.1 mg/l is ...
Trivalent arsenic [As(III)] is currently approved by the FDA for the treatment of chronic and acute leukemias. However, As(III) has also demonstrated damaging effects on human health, including development of cardiovascular disease, diabetes, and cancer. Further, As(III) is a potent angiogenic agent …
Spirulina is blue - green algae that grow both in fresh and salt water. For many years, the alga has used for various health purposes around the world. This nutrient-rich alga is a natural supplement that provides amazing health benefits to the users. Here are the benefits of Spirulina.. #1. Detoxing properties The studies show that regular intake of Spirulina can effectively detox heavy metals such as Arsenic. It has been demonstrated that chronic Arsenic toxicity is common in most parts of the world. Millions of people consume Arsenic through drinking water. Apparently, there is no specific treatment for arsenic toxicity. However, the clinical trials have proven that Spirulina can significantly reduce the level of toxicity in the body.. #2. Packed with essential nutrients Our bodies require essential nutrients for proper functioning. Fortunately, Spirulina is rich in essential nutrients and low in calories. The algae manufacture its food through photosynthesis thus making it rich in vital ...
ABSTRACTHuman arsenic (+3 oxidation state) methyltransferase (AS3MT) is known to catalyze the methylation of arsenite. The objective of this study was to investigate the diversity of the AS3MT gene at the global level. The distribution of 18 single nucleotide polymorphisms (SNPs) in AS3MT was perfor
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Skin is the largest organ of the body.It is a major barrier between the body and the external environment. Main Functions of skin: Protection: It forms a protection layer against mechanical/thermal/chemical stress, infection Sensation: skin contains touch, pressure, pain and … Read More … ...
Skin is the largest organ of the body.It is a major barrier between the body and the external environment. Main Functions of skin: Protection: It forms a protection layer against mechanical/thermal/chemical stress, infection Sensation: skin contains touch, pressure, pain and … Read More … ...
1310 Arsenite Schism of Constantinople is officially ended by the reconciliation of the Arsenites to the Josephites, in a ... 1265-1310 Arsenite Schism of Constantinople, beginning when Patr. Arsenius Autorianus excommunicated emperor Michael VIII ... 18(1948), 202-220.) Alexander P. Kahzdan (Ed). "Arsenites." The Oxford Dictionary of Byzantium. Oxford University Press, 2012. ...
... (EC 1.20.2.1, arsenite oxidase) is an enzyme with systematic name arsenite:cytochrome c ... vanden Hoven RN, Santini JM (June 2004). "Arsenite oxidation by the heterotroph Hydrogenophaga sp. str. NT-14: the arsenite ... This enzyme catalyses the following chemical reaction arsenite + H2O + 2 oxidized cytochrome c ⇌ {\displaystyle \ ... "Arsenite oxidase from Ralstonia sp. 22: characterization of the enzyme and its interaction with soluble cytochromes". The ...
Arsenite is the most stable soluble form of arsenic in reducing environments and arsenate, which is less mobile than arsenite, ... Arsenite is more soluble and mobile than arsenate. Many species of bacteria can transform arsenite to arsenate in anoxic ... Chemoautotrophic arsenite oxidizers (CAO) and heterotrophic arsenite oxidizers (HAO) convert As(III) into As(V). CAO combine ... Arsenite of lime and arsenate of lead were used widely as insecticides until the discovery of DDT in 1942. The toxicity of ...
Arsenite minerals are much less common. Both the Dana and the Strunz mineral classifications place the arsenates in with the ...
... , also called Schloss Green, is chemically a cupric hydrogen arsenite (also called copper arsenite or acidic ... This produced a sodium arsenite solution. Added to a copper sulfate solution, it produced a green precipitate of effectively ... copper arsenite salt (CuHAsO 3 and Cu(AsO 3) 2·3H 2O)), neutral copper orthoarsenite (3CuO·As 2O 3·2H 2O), copper arsenate ( ... copper arsenite), CuHAsO 3. It is chemically related to Paris Green. It is a yellowish-green pigment which in the past was used ...
Thus, it dissolves readily in alkaline solutions to give arsenites. It is less soluble in acids, although it will dissolve in ... Bulk arsenic-based compounds sodium arsenite and sodium cacodylate are derived from the trioxide.[citation needed] A variety of ...
The systematic name of this enzyme class is arsenite:azurin oxidoreductase. This enzyme is also called arsenite oxidase. The ... Ellis PJ, Conrads T, Hille R, Kuhn P (2001). "Crystal structure of the 100 kDa arsenite oxidase from Alcaligenes faecalis in ... Arsenate reductase (azurin) (EC 1.20.9.1) is an enzyme that catalyzes the chemical reaction arsenite + H2O + 2 azurinox ⇌ {\ ... Anderson GL, Williams J, Hille R (1992). "The purification and characterization of arsenite oxidase from Alcaligenes faecalis, ...
nov., an arsenite-oxidizing bacterium isolated from agricultural soil in Thailand". J. Gen. Appl. Microbiol. 58 (3): 245-51. ... C. terrae has an arsenite-oxidizing ability. "Archived copy". Retrieved 2013-05-10. http://www.straininfo.net/strains/874128 ...
nov., an arsenate-respiring and arsenite-oxidizing bacterium isolated from hydrothermal sediment". International Journal of ... Marinobacter santoriniensis can metabolize arsenate and arsenite. A.C. Parte. "Marinobacter". LPSN. Retrieved 2016-08-18. " ...
MM-1 isolated from a soil and identification of arsenite oxidase gene". Journal of Hazardous Materials. 262: 997-1003. doi: ... Bahar, Md Mezbaul; Megharaj, Mallavarapu; Naidu, Ravi (2013-11-15). "Kinetics of arsenite oxidation by Variovorax sp. ...
nov., an arsenite-oxidizing bacterium from Thai soil". Antonie van Leeuwenhoek. 106 (6): 1239-46. doi:10.1007/s10482-014-0294-1 ... Flavobacterium arsenitoxidans is a Gram-negative, arsenite-oxidizing, non-spore-forming, rod-shaped and aerobic bacterium from ...
nov., an arsenite-resistant bacterium isolated from soil". International Journal of Systematic and Evolutionary Microbiology. ...
nov., an arsenite-resistant bacterium isolated from soil". International Journal of Systematic and Evolutionary Microbiology. ... Xenophilus arseniciresistens is a Gram-negative, aerobic, arsenite-resistant and motile bacterium from the genus Xenophilus ...
Arsenite or Antimonite (out). The overall reaction catalyzed by ArsB-ArsA is: Arsenite or Antimonite (in) + ATP ⇌ Arsenite or ... Arsenic toxicity Arsenite Antimonite Ion transporter Ion transporter superfamily ARC3 family Arsenite-Antimonite efflux ... Arsenite resistance (Ars) efflux pumps of bacteria may consist of two proteins, ArsB (TC# 2.A.45.1.1; the integral membrane ... These pumps actively expel both arsenite and antimonite. Homologues of ArsB are found in Gram-negative and Gram-positive ...
... arsenite, hexachlorobenzene, and nickel compounds. Many teratogens exert specific effects on the fetus by epigenetic mechanisms ...
Induced by oxidative stress generated by arsenite treatment. Binding of nitric oxide (NO) to the heme iron in the N-terminal ...
... is a species of arsenite-oxidizing bacterium. Salmassi, Tina M.; Venkateswaren, Kasthuri; Satomi, ... Masataka; Newman, Dianne K.; Hering, Janet G. (2002). "Oxidation of Arsenite by Agrobacterium albertimagni , AOL15, sp. nov., ...
... cupric arsenite (CuHAsO3). Other pigments Green earth: also known as terre verte and Verona green (K[(Al,Fe3+ ),(Fe2+ ,Mg](AlSi ...
Arsenite is found to bond to sulfur compounds in the protein of degraded hair, which is a key component in bezoars. A famous ... The toxic compounds in arsenic are arsenate and arsenite. Each is acted upon differently, but effectively, by bezoar stones. ...
Arsenite (As(+3)), has a pKa of 9.3, and occurs at a neutral or acidic pH as As(OH)3. Arsenite in water can be thought of as an ... On the other hand, arsenite is more common in anaerobic environments, more mobile, and more toxic than arsenate. Arsenite is 25 ... Living cells (microbial or human) are generally exposed to arsenic as arsenate or arsenite. Arsenate (As(+5)) has a pKa of 7.0 ... In microbial biofilms growing on the rock surfaces of anoxic brine pools fed by hot springs containing arsenite and sulfide at ...
The presence or absence of P does not affect the uptake of arsenite, which translocates more easily than arsenate. C. Tu, L.Q. ... arsenite as a noncompetitive inhibitor). Priel 1995. Gurta et al. 1994 L.E. Bennetta; J.L. Burkheada; K.L. Halea; N. Terry; M. ... the plants then absorbs 10 times more arsenate than arsenite. If on the other hand the P supply is increased, As uptake ...
... has the ability to oxidize arsenite to arsenate. The complete genome of A. arsenitoxydans has been ...
nov., an arsenite-resistant bacterium isolated from iron-mined soil". International Journal of Systematic and Evolutionary ... Lysobacter arseniciresistens is a Gram-positive, rod-shaped, aerobic, arsenite-resistant and motile bacterium from the genus of ...
This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out ... thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion. Carlin A ... ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite ...
2001) with arsenite-exposed human lung A549, kidney UOK123, UOK109 and UOK121 cells isolated eight different DNA fragments by ... Cavigelli M, Li WW, Lin A, Su B, Yoshioka K, Karin M (November 1996). "The tumor promoter arsenite stimulates AP-1 activity by ... MRP1-overexpressing lung tumor GLC4/Sb30 cells poorly accumulate arsenite and arsenate. This is mediated through MRP-1 ... Zhong CX, Mass MJ (July 2001). "Both hypomethylation and hypermethylation of DNA associated with arsenite exposure in cultures ...
... is a Gram-negative, non-spore-forming and arsenite-oxidizing bacterium from the genus of Microvirga which has ... nov., an arsenite-oxidizing Alphaproteobacterium, isolated from metal industry waste soil". International Journal of Systematic ...
It is both arsenate and arsenite mineral, a combination that is rare in the world of minerals. Arakiite is stoichiometrically ... Other minerals bearing both arsenite and zinc include kraisslite and mcgovernite. The mineral crystallizes in the monoclinic ...
... also known as arsenical pump-driving ATPase and arsenite-stimulated ATPase is an enzyme that in humans is encoded ... Kurdi-Haidar B, Heath D, Lennon G, Howell SB (2000). "Chromosomal localization and genomic structure of the human arsenite- ... Kurdi-Haidar B, Heath D, Aebi S, Howell SB (1998). "Biochemical characterization of the human arsenite-stimulated ATPase (hASNA ... 1998). "Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I)". J. Cell. Biochem. ...
Theodora herself was an Arsenite, but more moderate than her mother. Indeed, she formed a close bond with the new patriarch, ... The problem of the Arsenites, the supporters of deposed Patriarch Arsenios, who refused to recognize his successors, remained. ...
Arsenate reduction and arsenite oxidation have been observed in microbes (Chrysiogenes arsenatis). Additionally, some ... prokaryotes can use arsenate as a terminal electron acceptor during anaerobic growth and some can utilize arsenite as an ...
Some arsenite salts can be prepared from an aqueous solution of As2O3. Examples of these are the meta-arsenite salts and at low ... A number of different arsenite anions are known: AsO3− 3 ortho-arsenite, an ion of arsenous acid, with a pyramidal shape [AsO− ... Well known examples of arsenites include sodium meta-arsenite which contains a polymeric linear anion, [AsO− 2] n, and silver ... IUPAC have recommended that arsenite compounds are to be named as arsenate(III), for example ortho-arsenite is called ...
Arsenite oxidase may refer to: Arsenate reductase (cytochrome c) Arsenate reductase (azurin) This disambiguation page lists ... articles associated with the title Arsenite oxidase. If an internal link led you here, you may wish to change the link to point ...
The substance may have effects on the skin, mucous membranes, bone marrow, blood, central nervous system, peripheral nervous system and liver. This may result in pigmentation disorders, perforation of the nasal septum, anaemia, nervous system impairment and liver impairment. This substance is carcinogenic to humans. Causes toxicity to human reproduction or development ...
This is unique source of information on the chemicals manufactured and imported in Europe. It covers their hazardous properties, classification and labelling, and information on how to use them safely.. REACH. ...
Lead arsenite. Regulatory process names 6 CAS names 1 IUPAC names 1 Other identifiers 2 ...
Trisilver arsenite. Regulatory process names 4 IUPAC names 1 Other identifiers 1 ...
"Arsenites" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Arsenites" by people in Harvard Catalyst Profiles by year, and ... Transcriptomics analysis defines global cellular response of Agrobacterium tumefaciens 5A to arsenite exposure regulated ... Below are the most recent publications written about "Arsenites" by people in Profiles. ...
This page contains information on the chemical Copper arsenite including: 17 synonyms/identifiers; U.S. Code of Federal ... Copper arsenite*Copper arsenite [UN1586] [Poison]*Copper arsonate*Copper orthoarsenite*Copper(II) arsenite*CUPRIC ARSENITE* ... Copper arsenite. Identifications. *Caswell Number: 233*Synonyms/Related:*Acid copper arsenite*Air-flo Green*Arsenious acid ( ... Copper arsenite. No. No. Related Resources. *USDOT Hazardous Materials Table 49 CFR 172.101. An online version of the USDOTs ...
This page contains information on the chemical Strontium arsenite including: 3 synonyms/identifiers; U.S. Code of Federal ... Strontium arsenite*Strontium arsenite (Sr(AsO2) 2) 49 CFR 172.101 - Hazardous Materials Table. Hazardous materials description ... Strontium arsenite (EnvironmentalChemistry.com),/a,- This page contains information on the chemical Strontium arsenite ... Strontium arsenite. 6.1. UN1691. II. 6.1. IB8, IP2, IP4, T3, TP33. 153. 212. 242. Forbid. Forbid. A. ...
... Zhibin Zhang,1,2 Yulin Sun,1 Cuizhen Sun,1 Ning Wang,1 ... Adsorption of arsenite using six submerged plants (Mimulicalyx rosulatus, Potamogeton maackianus, Hydrilla, Watermifoil, Pteris ...
Potassium Arsenite (Fowlers Solution) Potassium Arsenite (Fowlers Solution). a" data-cycle-caption="#nmah-edan-caption" data- ...
Article Removal of arsenite from water by soil biotechnology. In this paper we present oxidation of As(III) to As(V) by ... No comments were found for Removal of arsenite from water by soil biotechnology. Be the first to comment! ... Keywords: arsenic oxidation, SBT, soil biotechnology, As (III) adsorption, hydrous ferric oxide, arsenite, bioremediation, ...
Strychnidin-10-one, arsenite (1:1) Regulatory process names 2 CAS names 1 IUPAC names 1 Other identifiers 1 ...
... low-level sodium arsenite induced apoptosis via caspase-3 in INS-1 cells. Knockdown of ASK1 alleviated sodium arsenite-induced ... Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic β-cells.. Yao XF1, Zheng BL1, Bai J1 ... After treatment with low-level (0.25-1μM) sodium arsenite for 96h, the thioredoxin reductase (TrxR) activity was decreased ... In our previous study, we reported that sodium arsenite induced ROS-dependent apoptosis through lysosomal-mitochondrial pathway ...
J. Pi, Y. He, C. Bortner et al., "Low level, long-term inorganic arsenite exposure causes generalized resistance to apoptosis ... Culture media, FBS, and supplements were purchased from Invitrogen (Carlsbad, CA, USA). Sodium arsenite and curcumin were ... Our previous studies reveal that oxidative stress occurs in response to inorganic arsenite (iAs3+) exposure [5-8], which may ... "Nrf2 protects human bladder urothelial cells from arsenite and monomethylarsonous acid toxicity," Toxicology and Applied ...
Sodium arsenite was used by taxidermists in arsenical soaps for cleaning and sterilizing hides. It was also used as an ... Retrieved from "http://cameo.mfa.org/index.php?title=Sodium_arsenite&oldid=40138" ...
By stimulating human endothelial cells (SVEC4-10) with arsenite, we found that arsenite modulated the integrity of actin ... Further, we found arsenite increased the cell motility, indicating that structural ch ... Arsenite is a human carcinogen, however, the molecular mechanisms involved are poorly understood. ... By stimulating human endothelial cells (SVEC4-10) with arsenite, we found that arsenite modulated the integrity of actin ...
This arsenite exposure resulted in HIF-1A accumulation and increased glycolysis, similar to the physiologic response to hypoxia ... Constant exposure to 1 µM arsenite (As) resulted in the early loss of anchorage-dependent growth, measured by soft agar colony ... and it has been found to accumulate during arsenite exposure under oxygen-replete conditions. We modeled arsenic-exposed human ...
Sodium arsenite Ellagic acid Hematological parameters Cardioprotection Rat This is a preview of subscription content, log in to ... Group 2 was orally treated with sodium arsenite (SA, 10 mg/kg) for 21 days. Group 3 was orally treated with EA (30 mg/kg) for ... Chen, C., Jiang, X., Hu, Y., & Zhang, Z. (2013). The protective role of resveratrol in the sodium arsenite-induced oxidative ... Adil, M., Kandhare, A. D., Visnagri, A., & Bodhankar, S. L. (2015). Naringin ameliorates sodium arsenite-induced renal and ...
An arsenite-resistant strain of Leishmania donovani was generated in vitro by sequential exposure to higher concentrations of ... Arsenite-resistant Leishmania donovani promastigotes express an enhanced membrane P-type adenosine triphosphatase activity that ... sodium m-arsenite. The resistant strain displayed a low level of cross-resistance to structurally unrelated drugs such as ...
Arsenite oxidation. Bosea sp. WAO is able to grow under chemolithoautotrophic conditions with arsenite in addition to growing ... The arsenite oxidase genes (aroAB) in novel chemoautotrophic arsenite oxidizers. Biochem Biophys Res Commun. 2007;354:662-7. ... Operon structure for arsenite oxidation viewed 5′-3′ direction on the plus strand. The gene order is the same in both Bosea sp ... WAO, only the large subunit gene for the arsenite oxidation pathway aioA (EF015463) was amplified by traditional PCR [1, 16]. ...
The present study aimed at comparing the toxic effect of DMMTA(V) with that of inorganic arsenite (iAs(III)) on cell viability ... Arsenites / pharmacokinetics, toxicity. Cacodylic Acid / analogs & derivatives, pharmacokinetics, toxicity. Carcinogenicity ... 0/Aquaporins; 0/Arsenicals; 0/Arsenites; 0/Environmental Pollutants; 0/Reactive Oxygen Species; 0/dimethylmonothioarsinic acid ... and because the resistance of cells to arsenite can be influenced by lower arsenic uptake due to lower expression of aquaporin ...
... arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol ... transporter activity protein binding ATP binding nucleus nucleolus cytoplasm endoplasmic reticulum membrane transport arsenite ... transporter activity protein binding ATP binding nucleus nucleolus cytoplasm endoplasmic reticulum membrane transport arsenite ...
Arsenite efflux transporter ArsBImported. ,p>Information which has been imported from another database using automatic ... tr,Q735E4,Q735E4_BACC1 Arsenite efflux transporter ArsB OS=Bacillus cereus (strain ATCC 10987 / NRS 248) OX=222523 GN=BCE_3208 ...
... are increased in the protozoan parasite Leishmania selected for resistance to the heavy metal arsenite. The levels of ... Stable transfection of the ODC gene increases the level of trypanothione, which can contribute to arsenite resistance. In ... Elevated levels of polyamines and trypanothione resulting from overexpression of the ornithine decarboxylase gene in arsenite- ... are increased in the protozoan parasite Leishmania selected for resistance to the heavy metal arsenite. The levels of ...
PubMed journal article Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in ... Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis elegans.. ... TY - JOUR T1 - Arsenite exposure accelerates aging process regulated by the transcription factor DAF-16/FOXO in Caenorhabditis ... In addition, arsenite exposure (100 μM) caused significant changes of age-dependent biomarkers, including a decrease of ...
The three ars genes conferred arsenite resistance in E. coli and arsenite as well as arsenate resistance in Bacillus subtilis. ... The arsenate, arsenite, and antimonite resistance was shown to be inducible by all three heavy metal ions. Inactivation of the ... The arsenate, arsenite, and antimonite resistance region of the Staphylococcus xylosus plasmid pSX267 was subcloned in ... The inactivation of arsR also resulted in reduction of resistance to arsenite and antimonite, while arsenate resistance was ...
An extracellular pH-driven targeted multifunctional manganese arsenite delivery system for tumor imaging and therapy ... An extracellular pH-driven targeted multifunctional manganese arsenite delivery system for tumor imaging and therapy K. Zhang, ...
Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation.. [ ... We previously reported that the sustained exposure of human urothelial cells (HUCs) to low-dose sodium arsenite induces changes ...
Arsenite has also been shown to induce activation of mitogen-activated protein kinase (MAPK)3 (2) family member proteins, some ... Arsenite induces apoptosis in Chinese hamster ovary cells by generation of reactive oxygen species. J. Cell. Physiol. 169: 256 ... 8⇑B). Arsenite-mediated c-Jun phosphorylation was also completely inhibited by curcumin and partially by SB203580 (Fig. 7⇑, B ... Arsenite Induces Apoptosis of Murine T Lymphocytes Through Membrane Raft-Linked Signaling for Activation of c-Jun Amino- ...
  • Our previous studies reveal that oxidative stress occurs in response to inorganic arsenite (iAs 3+ ) exposure [ 5 - 8 ], which may partly account for the dermal toxicity of iAs 3+ , including hyperkeratosis and carcinogenesis. (hindawi.com)
  • N -acetylcysteine and meso-2,3-dimercaptosuccinic acid alleviate oxidative stress and hepatic dysfunction induced by sodium arsenite in male rats. (springer.com)
  • Environmentally Relevant Concentrations of Arsenite Induce Dose-Dependent Differential Genotoxicity Through Poly(ADP-Ribose) Polymerase Inhibition and Oxidative Stress in Mouse Thymus Cells. (sigmaaldrich.com)
  • Arsenite did not decrease intracellular glutathione or increase lipid peroxidation, suggesting that the effect of arsenite on CYP3A23 does not involve oxidative stress. (ovid.com)
  • Arsenite induces production of reactive oxygen species at high levels with subsequent development of oxidative stress, which affects multiple targets in the cell. (nih.gov)
  • Suppression of protective signaling pathways that play a protective role against arsenite-induced oxidative stress and apoptosis dramatically accelerates arsenite-induced apoptosis of resistant metastatic melanomas. (nih.gov)
  • The antioxidant actions of 80% ethanolic extract of dried flowers of Hibiscus sabdariffa L. (HSE) on lipid peroxidation (LPO), reduced glutathione (GSH), glutathione-s-transferase (GST), catalase (CAT), superoxide dismutase (SOD) and vitamin C (VITC), were examined using a model of sodium arsenite (SA) - induced oxidative stress in rats. (scialert.net)
  • In this protocol, we describe how to measure the sensitivity to oxidative stress from two different sources, arsenite and tBHP, using the nematode C. elegans . (bio-protocol.org)
  • In mammals, other oxidative stress reagents including sodium arsenite [26, 50, 51] and hydrogen peroxide [52-55] strongly induce SG formation, although the latter triggers a noncanonical type of SG. (thefreedictionary.com)
  • A proteome analysis of the arsenite response in cultured lung cells: evidence for in vitro oxidative stress-induced apoptosis. (naver.com)
  • Oxidative stress is also implicated in many aspects of arsenic toxicity, and a recent in vitro study suggests that transcription factor NF-E2-related factor 2 (Nrf2)-mediated antioxidant response may influence arsenite-induced impairment of glucose-stimulated insulin secretion in β-cells at low concentrations of arsenite (Fu et al. (medscape.com)
  • Transcriptomics analysis defines global cellular response of Agrobacterium tumefaciens 5A to arsenite exposure regulated through the histidine kinases PhoR and AioS. (harvard.edu)
  • An arsenite-resistant strain of Leishmania donovani was generated in vitro by sequential exposure to higher concentrations of sodium m-arsenite. (nih.gov)
  • In this study, we investigated the effects and the underlying mechanisms of chronic arsenite exposure on the aging process in Caenorhabditis elegans. (unboundmedicine.com)
  • The results showed that prolonged arsenite exposure caused significantly decreased lifespan compared to non-exposed ones. (unboundmedicine.com)
  • In addition, arsenite exposure (100 μM) caused significant changes of age-dependent biomarkers, including a decrease of defecation frequency, accumulations of intestinal lipofuscin and lipid peroxidation in an age-dependent manner in C. elegans. (unboundmedicine.com)
  • Further evidence revealed that intracellular reactive oxygen species (ROS) level was significantly increased in an age-dependent manner upon 100 μM arsenite exposure. (unboundmedicine.com)
  • Moreover, the mRNA levels of transcriptional makers of aging (hsp-16.1, hsp-16.49, and hsp-70) were increased in aged worms under arsenite exposure (100 μM). (unboundmedicine.com)
  • Finally, we showed that daf-16 mutant worms were more sensitive to arsenite exposure (100 μM) on lifespan and failed to induce the expression of its target gene sod-3 in aged daf-16 mutant under arsenite exposure (100 μM). (unboundmedicine.com)
  • Our study demonstrated that chronic arsenite exposure resulted in accelerated aging process in C. elegans. (unboundmedicine.com)
  • The overproduction of intracellular ROS and the transcription factor DAF-16/FOXO play roles in mediating the accelerated aging process by arsenite exposure in C. elegans. (unboundmedicine.com)
  • Long-term low-dose exposure of human urothelial cells to sodium arsenite activates lipocalin-2 via promoter hypomethylation. (sigmaaldrich.com)
  • We previously reported that the sustained exposure of human urothelial cells (HUCs) to low-dose sodium arsenite induces changes in the gene expression profile and neoplastic transformation. (sigmaaldrich.com)
  • Although hypoxia-inducible factor-1α (HIF-1α) has been reported to be activated by arsenite both in vivo and in vitro, the detailed molecular mechanisms leading to HIF-1α expression and activation due to arsenite exposure have not been well understood. (aacrjournals.org)
  • Knockout of p85α in MEFs (p85α−/−) led to the deficiency of HIF-1α protein accumulation induced by arsenite exposure, suggesting that p85α is crucial for arsenite-induced stabilization of HIF-1α protein. (aacrjournals.org)
  • At the same time, our studies also show that p85a exhibited an inhibition of HIF-1α protein degradation via PI-3K/Akt-dependent pathway in cellular response to arsenite exposure. (aacrjournals.org)
  • Taken together, our studies demonstrated that p85α-mediated HIF-1α stabilization due to arsenite exposure is specific through p85α mediation of HSF-1 activation and subsequently transcriptional up-regulation of the inducible Hsp70. (aacrjournals.org)
  • During this course, p85 regulated inducible Hsp70 expression transcription through PI-3K/Akt/HSF-1 pathway upon arsenite exposure. (aacrjournals.org)
  • This study evaluates the effect of combined exposure to potassium heptaoxochromate VI (K2Cr2O7) and sodium arsenite (NaAsO2) in mice as well as the effect of methanol leaf extracts of Rauvolfia vomitoria (MRV) on the toxicity of both toxicants. (aacrjournals.org)
  • Northern hybridization and western blot analysis revealed that exposure of A6 cells to 1-10 μM sodium arsenite at a mild heat shock temperature of 30˚C enhanced hsp30 and hsp70 gene expression to a much greater extent than found with either stress individually. (uwaterloo.ca)
  • Finally, prior exposure of A6 cells to concurrent sodium arsenite (10 μM ) and heat shock (30 ˚C) treatment conferred thermotolerance since it protected them against a subsequent thermal challenge at 37 ˚C. Acquired thermotolerance was not observed with cells treated with the two mild stresses individually. (uwaterloo.ca)
  • Long-term exposure of arsenite leads to human skin cancer. (nih.gov)
  • In this study, we investigated the potential role of PI-3K/Akt/cyclin D1in the transformation of human keratinocytic cells upon arsenite exposure. (nih.gov)
  • We used the soft agar assay to evaluate the cell transformation activity of arsenite exposure and the nude mice xenograft model to determine the tumorigenesis of arsenite-induced transformed cells. (nih.gov)
  • Our results showed that repeated long-term exposure of HaCat cells to arsenite caused cell transformation, as indicated by anchorage-independent growth in soft agar. (nih.gov)
  • Treatment of cells with arsenite also induced significant activation of PI-3K and Akt, which was responsible for the anchorage-independent cell growth induced by arsenite exposure. (nih.gov)
  • In addition, our published studies have shown that arsenite exposure is able to activate PI-3K in mouse epidermal Cl41 cells (Ouyang et al. (nih.gov)
  • The results showed that the arsenite exposure did increase PI-3K activation in HaCat cells compared with the medium control (Figure 2A, B). We also further confirmed this finding in NHEKs (Figure 2C, D). The aforementioned data demonstrate that PI-3K is implicated in human keratinocyte response to arsenite exposure. (nih.gov)
  • Effects of prenatal exposure to sodium arsenite on motor and food-motivated behaviors from birth to adulthood in C57BL6/J mice. (semanticscholar.org)
  • Furthermore, the whole core transcription element circuitry that control self-renewal of mouse ESC (Stat3-P-Tyr705, April4, Sox2 and Nanog) was strongly down-regulated by sodium arsenite (4 M) exposure. (sunolmolecular.com)
  • We possess additional recommended in the present research that sodium arsenite exposure might target the embryonic neurogenesis in mice via interference and interaction with cell signaling pathways in mouse neural stem/precursor cells. (sunolmolecular.com)
  • As expected, total levels of cell death were higher, than apoptotic levels after sodium arsenite exposure of mouse ESC, due to induction of necrosis (Fig. 1d). (sunolmolecular.com)
  • In flow cytometric analysis, arsenite potentiated phosphatidylserine (PS) exposure and microparticle (MP) formation, the major mediators of procoagulant activity. (hanyang.ac.kr)
  • Arsenite also inhibited flippase, an enzyme that restores PS to the inner leaflet, suggesting that PS could be retained in outer membranes after exposure. (hanyang.ac.kr)
  • In conclusion, arsenite-enhanced procoagulant activity in platelets by PS exposure and MP generation ultimately results in accelerated thrombus formation in vivo, suggesting that this enhanced activity is a possible contributing factor in CVD associated with chronic exposure to arsenic through drinking water. (hanyang.ac.kr)
  • Cytotoxicity and genotoxicity has beenevaluated by exposure of IEC-6 cells to arsenate (5mM)and arsenite (1.5mM)at low concentrations. (manipal.edu)
  • Adsorption of arsenite using six submerged plants ( Mimulicalyx rosulatus , Potamogeton maackianus , Hydrilla , Watermifoil , Pteris vittata , and Potamogeton crispus ) as adsorbing materials was investigated. (hindawi.com)
  • Adsorption of Arsenite onto Kemiron" by Douglas Oti, Joniqua A. Howard et al. (usf.edu)
  • and Trotz, Maya A., "Adsorption of Arsenite onto Kemiron" (2011). (usf.edu)
  • This paper investigated the synthesis of Zinc oxide-Pary Mountain Mine (PMM)-goethite composite and its performance in the adsorption of arsenite. (alliedacademies.org)
  • Batch mode techniques at ambient temperature were used to test the adsorption of arsenite on zinc oxide PMM coated goethite. (alliedacademies.org)
  • Low-level sodium arsenite induces apoptosis through inhibiting TrxR activity in pancreatic β-cells. (nih.gov)
  • In our previous study, we reported that sodium arsenite induced ROS-dependent apoptosis through lysosomal-mitochondrial pathway in pancreatic β-cells. (nih.gov)
  • Since the thioredoxin (Trx) system is the key antioxidant factor in mammalian cells, we investigate whether the inhibition of Trx system contributes to sodium arsenite-induced apoptosis in this study. (nih.gov)
  • Finally, low-level sodium arsenite induced apoptosis via caspase-3 in INS-1 cells. (nih.gov)
  • Knockdown of ASK1 alleviated sodium arsenite-induced apoptosis. (nih.gov)
  • Arsenite has also been shown to induce activation of mitogen-activated protein kinase (MAPK) 3 ( 2 ) family member proteins, some of which may play a key role in apoptosis induction in leukemia cells ( 10 ). (jimmunol.org)
  • Recent studies conducted in the laboratory of Dr. Tom K. Hei, Professor of Environmental Health Sciences in the Mailman School of Public Health at Columbia University, have shown that short term treatment with low to moderate concentrations of sodium arsenite (2-10 uM), which has little or no effects on normal melanocytes, induces apoptosis of human melanoma, including highly metastatic ones, by more than 6 fold. (nih.gov)
  • In studies conducted in Dr. Hei's laboratory, Dr. Vladimir Ivanov has found that low to moderate concentrations of arsenite has little or no effect on normal melanocytes, but induces high levels of apoptosis in melanomas in spite of their low surface Fas levels. (nih.gov)
  • Induction of Apoptosis in the Rat Bone Marrow Mesenchymal Stem Cells Following Sodium Arsenite Treatment with the Dose Lesser than that Used for Treatment of Malignant Patient. (thefreedictionary.com)
  • Markers indicative of apoptosis (phosphatidylserine externalization, PARP cleavage, and sensitivity to caspase inhibition) were uniformly negative in arsenite exposed cells. (elsevier.com)
  • Taken together, these data suggest that a possible mechanism of arsenite-induced apoptosis is the accumulation of ubiquitinated proteins and impairment of the protein degradative pathway. (naver.com)
  • The primary speculation, which acquired been attended to in the present research, was that salt arsenite might focus on many signaling paths in ESC straight, controlling self-renewal and marketing apoptosis. (sunolmolecular.com)
  • a Phase contrast microscopy (40 magnification) of mouse ESC (cultured as adherent cells) in the absence and in the presence of 4 M sodium arsenite, … FACS assays of PI-stained nuclei revealed strong dose-dependent changes in cell cycle regulation for stem cells that resulted in G2/M arrest 24 h after arsenic treatment followed by pronounced apoptosis 48 h after treatment (Fig. 1dCf). (sunolmolecular.com)
  • Evidence for toxicity differences between inorganic arsenite and thioarsenicals in human bladder cancer cells. (biomedsearch.com)
  • Sodium arsenite (SA) is used as medicin, pestisides as well as in many other industries, which finally can cause the toxicity of human and other animals. (sid.ir)
  • Protective effect of naringin on sodium arsenite induced testicular toxicity via modulation of biochemical perturbations in experimental rats. (scialert.net)
  • The purpose of this experiment is to test if there is a potential for human toxicity to sodium arsenite (NaAsO 2 ) by examining cell death in A549 cells acutely exposed NaAsO 2 . (ommegaonline.org)
  • The ability of arsenite to induce autophagy in lymphoblastoid cell lines introduces a potentially novel mechanistic explanation of the well-characterized in vitro and in vivo toxicity of arsenic to lymphoid cells. (elsevier.com)
  • To understand the role of glutathione (GSH) in the protection of cells from arsenite toxicity, we studied the mechanism of apoptotic cell death in cells genetically unable to synthesize GSH (GCS-2 cells). (naver.com)
  • CONCLUSION: This study has pin-pointed core functions that protect cells from arsenite and cadmium toxicity. (chalmers.se)
  • Arsenic methylation efficiency, a susceptibility factor for arsenic toxicity, is in adults partly explained by variation in arsenite methyltransferase (AS3MT) gene. (cdc.gov)
  • No comments were found for Removal of arsenite from water by soil biotechnology . (environmental-expert.com)
  • Sheikhmohammadi, Amir 2017-08-01 00:00:00 This study aimed to investigate the feasibility of carboxymethyl cellulose-stabilized iron nanoparticles (C-nZVI) for the removal of arsenite ions from aqueous solutions. (deepdyve.com)
  • Therefore, there is a need to mimic in the laboratory the removal of arsenite from hydrometallurgical contained-wastewater. (alliedacademies.org)
  • Mesoporous pellet adsorbent developed from mixing at an appropriate ratio of natural clay, iron oxide, iron powder, and rice bran was used to investigate the optimization process of batch adsorption parameters for treating aqueous solution coexisting with arsenate and arsenite. (gjesm.net)
  • The adsorption efficiency of coexisting arsenate and arsenite solution onto the new developed adsorbent was over 99% under the optimized experimental condition. (gjesm.net)
  • In chemistry, an arsenite is a chemical compound containing an arsenic oxoanion where arsenic has oxidation state +3. (wikipedia.org)
  • Previous studies in an acid-sulfate-chloride spring in Yellowstone National Park found that microbial arsenite [As(III)] oxidation is absent in regions of the spring outflow channel where H 2 S exceeds ∼5 μM and served as a backdrop for continued efforts in the present study. (asm.org)
  • It is composed of arsenite ions (AsO33− or AsO2−) with arsenic always existing in the +3 oxidation state, and potassium existing in the +1 oxidation state. (hazmattool.com)
  • Previous work with Agrobacterium tumefaciens strain 5A concluded that oxidation of antimonite [Sb(III)] and arsenite [As(III)] required different biochemical pathways. (openrepository.com)
  • These data are summarized in a model that functionally integrates arsenite oxidation in the adaptive response to As(III) in this microorganism. (biomedcentral.com)
  • Adsorption and catalytic oxidation of arsenite on Fe-Mn nodules in the presence of oxygen. (edu.sa)
  • A number of different arsenite anions are known: AsO3− 3 ortho-arsenite, an ion of arsenous acid, with a pyramidal shape [AsO− 2] n meta-arsenite, a polymeric chain anion. (wikipedia.org)
  • Well known examples of arsenites include sodium meta-arsenite which contains a polymeric linear anion, [AsO− 2] n, and silver ortho-arsenite, Ag3AsO3, which contains the trigonal AsO3− 3 anion. (wikipedia.org)
  • Fowler's solution first introduced in the 18th century was made up from As2O3 as a solution of potassium meta-arsenite, KAsO2. (wikipedia.org)
  • Potassium arsenite (KAsO2) is an inorganic compound that exists in two forms, potassium meta-arsenite (KAsO2) and potassium ortho-arsenite (K3AsO3). (hazmattool.com)
  • Sodium arsenite induces cyclooxygenase-2 expression in human uroepithelial cells through MAPK pathway activation and reactive oxygen species induction. (semanticscholar.org)
  • In the present study, I examined the effect of concurrent low doses of sodium arsenite and mild heat shock temperatures on the expression of hsp30 and hsp70 genes in Xenopus laevis A6 kidney epithelial cells. (uwaterloo.ca)
  • Results Sodium arsenite treatment modulates signaling pathways that control self-renewal and survival of mouse ESC In mouse ESC exposed to graded doses of sodium arsenite (1C6 M, 24C48 h), there was a dramatic dose-dependent reduction in cell survival as shown in Fig. 1. (sunolmolecular.com)
  • Group 2 was orally treated with sodium arsenite (SA, 10 mg/kg) for 21 days. (springer.com)
  • Cultured Caco-2 cells were treated with sodium arsenite and were then stimulated with IL-1β. (portlandpress.com)
  • Genetic basis of arsenite and cadmium tolerance in Saccharomyces cerevisiae. (chalmers.se)
  • RESULTS: To gain insight into metal action and cellular tolerance mechanisms, we carried out genome-wide screening of the Saccharomyces cerevisiae haploid and homozygous diploid deletion mutant collections and scored for reduced growth in the presence of arsenite or cadmium. (chalmers.se)
  • Arsenite-specific defence functions were related to cell cycle regulation, lipid and fatty acid metabolism, mitochondrial biogenesis, and the cytoskeleton whereas cadmium-specific defence functions were mainly related to sugar/carbohydrate metabolism, and metal-ion homeostasis and transport. (chalmers.se)
  • Molecular evidence indicated that the cytoskeleton is targeted by arsenite and that phosphorylation of the Snf1p kinase is required for cadmium tolerance. (chalmers.se)
  • In LMH cells, sodium arsenite, cadmium, and heat shock, but not heme, induced activity of the MAP kinases extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. (umassmed.edu)
  • Nanomolar concentrations of both cadmium and arsenite, two environmental estrogens present in cigarette smoke, have been documented in rapidly phosphorylating ERK1/2, a type of MAPK, in the human non-small cell lung cancer (NSCLC) line NHI-1793 in a manner similar to that of estrogen. (bellarmine.edu)
  • To determine whether GPR30, one of the three types of estrogen receptors, is necessary for the phosphorylation of MAPK, NHI-1793 cells were treated with 17β-estradiol, cadmium chloride, and sodium arsenite both in the presence and absence of G15 - a GPR30-specific antagonist - and MAPK levels were measured using immunoblot analysis. (bellarmine.edu)
  • As expected, the data revealed these nanomolar concentrations of endogenous and environmental estrogens were sufficient in phosphorylating ERK1/2 in under ten minutes and pretreatment with G15 reduced phosphorylation in cells treated with 17β estradiol and cadmium chloride, but not in those treated with arsenite. (bellarmine.edu)
  • Therefore, cadmium and estradiol likely utilize GPR30 to phosphorylate ERK1/2, while further research is needed to elucidate the mechanism of arsenite-induced ERK1/2 activation. (bellarmine.edu)
  • Krauss, Katarzyna, "The Effects of the Environmental Estrogens Cadmium and Arsenite on Phosphorylation of ERK1/2 via GPR30 in Human Lung Adenocarcinoma Cells" (2016). (bellarmine.edu)
  • Arsenite and Cadmium Activate MAPK/ERK via Membrane Estrogen Receptors" by Mary Huff et al. (bellarmine.edu)
  • Here, we examined the effect of cadmium chloride (CdCl 2 ) and sodium arsenite (NaAsO 2 ) on the proliferation of human lung adenocarcinoma cell lines. (bellarmine.edu)
  • The present study aimed at comparing the toxic effect of DMMTA(V) with that of inorganic arsenite (iAs(III)) on cell viability, uptake efficiency and production of reactive oxygen species (ROS) toward human bladder cancer EJ-1 cells. (biomedsearch.com)
  • We also observed that arsenite induced the formation of hygrogen radicals in SVEC4-10 cells, which are known to exert a regulatory role in arsenite induced effects on SVEC4-10 cells. (cdc.gov)
  • These results reveal the existence of novel molecular regulatory processes governing arsenite oxidase expression in H. arsenicoxydans . (biomedcentral.com)
  • The arsenate, arsenite, and antimonite resistance was shown to be inducible by all three heavy metal ions. (asm.org)
  • In the present study, the arsenite ions from contaminated solutions were removed by adsorption on the granola modified lemon peel. (ac.ir)
  • The Freundlich and Langmuir isotherm models were used to understand the adsorption relationship between the arsenite ions and functional groups on the lemon peel. (ac.ir)
  • The most prominent target of enzymatic inhibition by arsenite is IkB kinase-beta. (nih.gov)
  • In the present study, we found that arsenite is able to induce HIF-1α protein accumulation in both mouse epidermal Cl41 cells and mouse embryonic fibroblasts (MEFs). (aacrjournals.org)
  • While arsenite alone did not induce procoagulant activity, it significantly enhanced thrombin-induced procoagulant activity of human platelets in a concentration- and time-dependent manner. (hanyang.ac.kr)
  • The levels of trypanothione, a glutathione-spermidine conjugate, are increased in the protozoan parasite Leishmania selected for resistance to the heavy metal arsenite. (nih.gov)
  • We tested the hypothesis that sodium arsenite inhibits IL-6 production in stimulated enterocytes and that this effect of arsenite is caused by down-regulation of NF-κB activity. (portlandpress.com)
  • By stimulating human endothelial cells (SVEC4-10) with arsenite, we found that arsenite modulated the integrity of actin filaments, and stimulated the formation of cell motility organelle structures within 5 minutes. (cdc.gov)
  • The effects of arsenite on CYP3A23 transcription were examined using a luciferase reporter construct containing 1.4 kb of the CYP3A23 promoter. (ovid.com)
  • Since arsenite abolished induction of CYP3A23 protein, but caused only a small decrease in CYP3A23 mRNA, the effects of arsenite on translation of CYP3A23 mRNA were investigated. (ovid.com)
  • New inorganic (an)ion exchangers based on (alkoxide- free) sol-gel generated layered Mg-Al hydrous oxides for target anions (Arsenate, Arsenite , Fluoride, Bromide, Bromate, Selenite) removal. (thefreedictionary.com)
  • However, the exact mechanisms of arsenite-induced human skin carcinogenesis remain to be defined. (nih.gov)
  • IUPAC have recommended that arsenite compounds are to be named as arsenate(III), for example ortho-arsenite is called trioxidoarsenate(III). (wikipedia.org)
  • Western blotting with anti-AoxB antibodies and quantitative RT-PCR experiments allowed us to demonstrate that the rpoN and dnaJ gene products are involved in the control of arsenite oxidase gene expression. (biomedcentral.com)
  • Ortho-arsenite contrasts to the corresponding anions of the lighter members of group 15, phosphite which has the structure HPO2− 3 and nitrite, NO− 2 which is bent. (wikipedia.org)
  • PI-3K/Akt pathway-dependent cyclin D1 expression is responsible for arsenite-induced human keratinocyte transformation. (nih.gov)
  • 2006). To determine the potential involvement of the PI-3K pathway in arsenite-induced HaCat cell transformation, we tested the PI-3K activity in arsenite-exposed HaCat cells. (nih.gov)
  • We provide a novel scenario of the proapoptotic role of IkappaB kinase beta (IKKbeta)-NF-kappaB, which can act as the activator of the JNK pathway through the induction of GADD45alpha for triggering MKK4/JNK activation, in response to the stimulation of arsenite, a cancer therapeutic reagent. (exeter.ac.uk)
  • We D-(+)-Xylose supplier also elucidate a possible mechanism of the resistance to apoptotic death induced by sodium arsenite in neural stem/precursor cells based on the IL6CStat3 pathway. (sunolmolecular.com)
  • In these cultures, a 6-h treatment with 5 μM arsenite abolished dexamethasone (DEX)-mediated induction of CYP3A23 protein and activity, but did not inhibit general protein synthesis. (ovid.com)
  • In cells treated simultaneously with 10 μM sodium arsenite and different heat shock temperatures, enhanced accumulation of HSP30 and HSP70 protein was first detected at 26˚C with larger responses at 28 and 30 ˚C. HSF1 activity was involved in combined stress-induced hsp gene expression since the HSF1 activation inhibitor, KNK437, inhibited HSP30 and HSP70 accumulation. (uwaterloo.ca)
  • GM847 lung fibroblasts and HaCaT keratinocytes were exposed to sodium arsenite, As(III), and mRNA, protein levels and BER activity were assessed. (ovid.com)
  • Below are the list of possible Arsenite resistance protein products. (mybiosource.com)
  • Arsenite stimulated an increase in protein ubiquitination in GCS-2 cells while the wild-type cells were unaffected. (naver.com)
  • This construct was used to investigate the role of mitogen-activated protein (MAP) kinases in arsenite-mediated heme oxygenase-1 gene expression. (umassmed.edu)
  • Because the cellular uptake of iAs(III) is mediated by aquaporin proteins, and because the resistance of cells to arsenite can be influenced by lower arsenic uptake due to lower expression of aquaporin proteins (AQP 3, 7 and 9), the expression of several members of the aquaporin family was also examined. (biomedsearch.com)
  • Stable transfection of the ODC gene increases the level of trypanothione, which can contribute to arsenite resistance. (nih.gov)
  • Expression and regulation of the antimonite, arsenite, and arsenate resistance operon of Staphylococcus xylosus plasmid pSX267. (asm.org)
  • The arsenate, arsenite, and antimonite resistance region of the Staphylococcus xylosus plasmid pSX267 was subcloned in Staphylococcus carnosus. (asm.org)
  • The inactivation of arsR also resulted in reduction of resistance to arsenite and antimonite, while arsenate resistance was unaffected. (asm.org)
  • The three ars genes conferred arsenite resistance in E. coli and arsenite as well as arsenate resistance in Bacillus subtilis. (asm.org)
  • Seems to confer resistance to arsenite by allowing cells to extrude this compound. (mybiosource.com)
  • Resistance to arsenite (As(III)) by cells is generally accomplished by arsenite efflux permeases from Acr3 or ArsB unrelated families. (ac.be)
  • As(III) and antimonite (Sb(III)) resistance and accumulation studies using E. coli or C. glutamicum arsenite permease mutants clearly show that CgAcr3-1 is specific for As(III). (ac.be)
  • To identify additional molecules that mediate SKN-1 signaling to the NMJ, we performed a candidate screen for suppressors of aldicarb resistance caused by acute treatment with the SKN-1 activator arsenite. (genetics.org)
  • It is unclear, however, whether LCL autophagy is an effector mechanism of arsenite cytotoxicity or alternatively a cellular compensatory mechanism. (elsevier.com)
  • Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in" by Kimberly K. Elbirt, Alan J. Whitmarsh et al. (umassmed.edu)
  • Mechanism of sodium arsenite-mediated induction of heme oxygenase-1 in hepatoma cells. (umassmed.edu)
  • Arsenite removal from groundwater by iron-manganese oxides filter media: Behavior and mechanism. (edu.sa)
  • Arsenate is salt or ester of arsenic acid having a negative ion of AsO 4 3- , arsenite is a salt or ester of arsenious acid having a negative ion of AsO 4 3- derived from aqueous solutions of As 4 O 6 and arsenide is a negative, trivalent binary arsenic compound such as H 3 As or GaAs. (chemicalland21.com)
  • Lemon peel adsorbent presented good removal efficiency for arsenite in contaminated aqueous solutions and real water. (ac.ir)
  • Ameliorative role of conjugated linolenic acid isomers against oxidative DNA damage induced by sodium arsenite in rat model. (springer.com)
  • Under the reducing condition, leached out metals and compounds including ZnO-goethite interface will be negligible [ 20 ] The Eh-pH diagram of arsenic species as reported by [ 21 ] supported that arsenite exists in acid pH under reducing condition. (alliedacademies.org)
  • It is then distributed throughout the body, where it is reduced into arsenite if necessary, then methylated into monomethylarsenic (MMA) and dimethylarsenic acid (DMA) by arsenite methyltransferase. (t3db.ca)
  • Affinity absorption assays with GST-PAK-PBD demonstrated that arsenite activated small GTPase CDC42 and Rac. (cdc.gov)
  • In rat and human hepatocyte cultures, arsenic, in the form of arsenite, decreases the induction of several CYPs. (ovid.com)
  • We investigated the induction of heme oxygenase-1 by the tumor promoter arsenite in a chicken hepatoma cell line, LMH. (umassmed.edu)
  • Involvement of an AP-1 site in arsenite induction of heme oxygenase-1 gene expression was studied. (umassmed.edu)
  • The ability of GlpF (overexpressed under IPTG induction) to transport As(III) was tested by an arsenite uptake assay . (igem.org)
  • The inorganic forms (i.e. arsenite and arsenate predominate over other forms in the ecosystem [ 1 , 2 ]. (alliedacademies.org)
  • The contamination of drinking water by the two inorganic forms, arsenite As(III) and arsenate As(V), has been reported in different parts of the world [ 3 ] and constitutes a major threat of public health. (biomedcentral.com)
  • Bolt, AM, Byrd, RM & Klimecki, WT 2010, ' Autophagy is the predominant process induced by arsenite in human lymphoblastoid cell lines ', Toxicology and Applied Pharmacology , vol. 244, no. 3, pp. 366-373. (elsevier.com)
  • Furthermore, the addition of [Na.sub.2]EDTA has demonstrated that it prevented the loss of the arsenic compounds during the chromatographic separation, especially arsenite [18]. (thefreedictionary.com)
  • belongs to the class of inorganic compounds known as alkali metal arsenites. (t3db.ca)
  • These are inorganic compounds in which the largest oxoanion is arsenite, and in which the heaviest atom not in an oxoanion is an alkali metal. (t3db.ca)
  • Like many other arsenic containing compounds, potassium arsenite is highly toxic and carcinogenic to humans. (hazmattool.com)
  • Polysomal distribution analysis showed that arsenite decreased translation by decreasing the DEX-mediated increase in CYP3A23 mRNA association with polyribosomes. (ovid.com)
  • The present study aimed at identifying curcumin as a potent activator of nuclear factor erythroid 2-related factor 2 (NRF2) and demonstrating its protective effect against inorganic arsenite- (iAs 3+ -) induced cytotoxicity in human keratinocytes. (hindawi.com)
  • We investigated the cytotoxicity of sodium arsenite in LCL 18564 using a set of complementary markers for cell death pathways. (elsevier.com)
  • Interestingly, electron microscopy, acidic vesicle fluorescence, and expression of LC3 in LCL 18564 identified autophagy as an arsenite-induced process that was associated with cytotoxicity. (elsevier.com)
  • Autophagy, a cellular programmed response that is associated with both cellular stress adaptation as well as cell death appears to be the predominant process in LCL cytotoxicity induced by arsenite. (elsevier.com)
  • Fig. 1 Sodium arsenite treatment of mouse ESC induced G2/M arrest followed by apoptotic cell death. (sunolmolecular.com)
  • Trivalent arsenic derivatives (arsenite, As III ) with remarkable clinical efficacy in acute promyelocytic leukemia has been demonstrated to exhibit inhibitory effect against breast cancer cells. (biomedcentral.com)
  • Administration of trivalent arsenic derivatives (arsenite, As III ) such as arsenic trioxide (As 2 O 3 ) has demonstrated a remarkable efficacy in the treatment of relapsed and refractory acute promyelocytic leukemia (APL) patients. (biomedcentral.com)
  • Efflux permease CgAcr3-1 of Corynebacterium glutamicum is an arsenite-specific antiporter. (ac.be)
  • Therefore, we propose that CgAcr3-1 is an antiporter that catalyzes arsenite-proton exchange with residues Cys129 and Glu305 involved in efflux. (ac.be)
  • Arsenite is a human carcinogen, however, the molecular mechanisms involved are poorly understood. (cdc.gov)
  • Arsenite has long been known as a human carcinogen. (aacrjournals.org)
  • Arsenite treatment increased lipid peroxidation and induced ubiquitination of molecular chaperone Hsp90 and impaired its ability to bind cochaperone p50 Cdc-37 and client proteins Plk-1 and Cdk-4 in GCS-2 cells. (naver.com)
  • Note that in fields that commonly deal with groundwater chemistry, arsenite is used generically to identify soluble AsIII anions. (wikipedia.org)
  • A new facultative chemolithoautotrophic arsenite (As III )-oxidizing bacterium TCC9-4 was isolated from a hot spring microbial mat in Tengchong of Yunnan, China. (frontiersin.org)
  • Microbial arsenite [As(III)] chemolithotrophy was first reported by Ilyaletdinov and Abdrashitova ( 18 ) and then more recently by Santini et al. (asm.org)
  • We identified a heme oxygenase-1 promoter-driven luciferase reporter construct that was highly and reproducibly expressed in response to sodium arsenite treatment. (umassmed.edu)
  • In 2008, bacteria were discovered that employ a version of photosynthesis with arsenites as electron donors, producing arsenates (just like ordinary photosynthesis uses water as electron donor, producing molecular oxygen). (wikipedia.org)
  • This aerobic, gram negative microorganism is capable of facultative chemolithoautotrophic growth under aerobic conditions by oxidizing the electron donors arsenite, elemental sulfur, thiosulfate, polysulfide, and amorphous sulfur. (springer.com)
  • Using selective enrichment and isolation techniques with arsenite [As(III)] as the sole electron donor Bosea sp. (springer.com)