Arsenite Transporting ATPases
Adenosine Triphosphatases
Arsenic
A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
Proton-Translocating ATPases
Calcium-Transporting ATPases
Vacuolar Proton-Translocating ATPases
Ion Pumps
Antimony
Arsenate Reductases
Oxidoreductases that specifically reduce arsenate ion to arsenite ion. Reduction of arsenate is a critical step for its biotransformation into a form that can be transported by ARSENITE TRANSPORTING ATPASES or complexed by specific sulfhydryl-containing proteins for the purpose of detoxification (METABOLIC DETOXIFICATION, DRUG). Arsenate reductases require reducing equivalents such as GLUTAREDOXIN or AZURIN.
Plasma Membrane Calcium-Transporting ATPases
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Adenosine Triphosphate
Aquaglyceroporins
Antimony Potassium Tartrate
Amino Acid Sequence
Cation Transport Proteins
Alcaligenes faecalis
Gram-Negative Chemolithotrophic Bacteria
Ectothiorhodospiraceae
Sodium-Potassium-Exchanging ATPase
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
Archaeoglobus fulgidus
Vacuoles
Cell Membrane
Proton Pumps
Pteris
Sarcoplasmic Reticulum Calcium-Transporting ATPases
Saccharomyces cerevisiae
Arsenic Poisoning
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
Cadmium Chloride
Ralstonia
Biological Transport
Vanadates
Oxalobacteraceae
Copper
Saccharomyces cerevisiae Proteins
Multienzyme Complexes
Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. (1/104)
Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistant sublines of Chinese hamster V79 cells have now been isolated. In order to gain understanding of possible targets for arsenite's action, one arsenite-resistant subline, As/R28A, was chosen as a donor for a cDNA expression library. The library from arsenite-induced As/R28A cells was transfected into arsenite-sensitive As/S5 cells, and transfectants were selected for arsenite-resistance. Two cDNAs, asr1 and asr2, which confer arsenite resistance to arsenite-hypersensitive As/S5 cells as well as to wild-type cells, were isolated. asr1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin-like region fused to S30 ribosomal protein. Arsenite was previously shown to inhibit ubiquitin-dependent proteolysis. These results suggest that the tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite. (+info)Asp45 is a Mg2+ ligand in the ArsA ATPase. (2/104)
The ATPase activity of ArsA, the catalytic subunit of the plasmid-encoded, ATP-dependent extrusion pump for arsenicals and antimonials in Escherichia coli, is allosterically activated by arsenite or antimonite. Magnesium is essential for ATPase activity. To examine the role of Asp45, mutants were constructed in which Asp45 was changed to Glu, Asn, or Ala. Cells expressing these mutated arsA genes lost arsenite resistance to varying degrees. Purified D45A and D45N enzymes were inactive. The purified D45E enzyme exhibited approximately 5% of the wild type activity with about a 5-fold decrease in affinity for Mg2+. Intrinsic tryptophan fluorescence was used to probe Mg2+ binding. ArsA containing only Trp159 exhibited fluorescence enhancement upon the addition of MgATP, which was absent in D45N and D45A. As another measure of conformation, limited trypsin digestion was used to estimate the surface accessibility of residues in ArsA. ATP and Sb(III) synergistically protected wild type ArsA from trypsin digestion. Subsequent addition of Mg2+ increased trypsin sensitivity. D45N and D45A remained protected by ATP and Sb(III) but lost the Mg2+ effect. D45E exhibited an intermediate Mg2+ response. These results indicate that Asp45 is a Mg2+-responsive residue, consistent with its function as a Mg2+ ligand. (+info)The ATPase mechanism of ArsA, the catalytic subunit of the arsenite pump. (3/104)
The ArsA ATPase is the catalytic subunit of a novel arsenite pump, with two nucleotide-binding consensus sequences in the N- and C-terminal halves of the protein. The single tryptophan-containing Trp159 ArsA was used to elucidate the elementary steps of the ATPase mechanism by fluorescence stopped-flow experiments. The binding and hydrolysis of MgATP is a multistep process with a minimal kinetic mechanism (Mechanism 1). A notable feature of the reaction is that MgATP binding induces a slow transient increase in fluorescence of ArsA, which is independent of the ATP concentration, indicative of the build-up of a pre-steady state intermediate. This finding, coupled with a phosphate burst, implies that the steady-state intermediate builds up subsequent to product release. We propose that the rate-limiting step is an isomerization between different conformational forms of ArsA. kcat is faster than the phosphate burst, indicating that both nucleotide binding sites of ArsA are catalytic. Consistent with this interpretation, approximately 2 mol of phosphate are released per mole of ArsA during the phosphate burst. (+info)The anion-stimulated ATPase ArsA shows unisite and multisite catalytic activity. (4/104)
ArsA, an anion-stimulated ATPase, consists of two nucleotide binding domains, A1 in the N terminus and A2 in the C terminus of the protein, connected by a linker. The A1 domain contains a high affinity ATP binding site, whereas the A2 domain has low affinity and it requires the allosteric ligand antimonite for binding ATP. ArsA is known to form a UV-activated adduct with [alpha-(32)P]ATP in the linker region. This study shows that on addition of antimonite, much more adduct is formed. Characterization of the nature of the adduct suggests that it is between ArsA and ADP, instead of ATP, indicating that the adduct formation reflects hydrolysis of ATP. The present study also demonstrates that the A1 domain is capable of carrying out unisite catalysis in the absence of antimonite. On addition of antimonite, multisite catalysis involving both A1 and A2 sites occurs, resulting in a 40-fold increase in ATPase activity. Studies with mutant proteins suggest that the A2 site may be second in the sequence of events, so that its role in catalysis is dependent on a functional A1 site. It is also proposed that ArsA goes through an ATP-bound and an ADP-bound conformation, and the linker region, where ADP binds under both unisite and multisite catalytic conditions, may play an important role in the energy transduction process. (+info)Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. (5/104)
Four Nudix hydrolase genes, ysa1 from Saccharomyces cerevisiae, orf209 from Escherichia coli, yqkg from Bacillus subtilis, and hi0398 from Hemophilus influenzae were amplified, cloned into an expression vector, and transformed into E. coli. The expressed proteins were purified and shown to belong to a subfamily of Nudix hydrolases active on ADP-ribose. Comparison with other members of the subfamily revealed a conserved proline 16 amino acid residues downstream of the Nudix box, common to all of the ADP-ribose pyrophosphatase subfamily. In this same region, a conserved tyrosine designates another subfamily, the diadenosine polyphosphate pyrophosphatases, while an array of eight conserved amino acids is indicative of the NADH pyrophosphatases. On the basis of these classifications, the trgB gene, a tellurite resistance factor from Rhodobacter sphaeroides, was predicted to designate an ADP-ribose pyrophosphatase. In support of this hypothesis, a highly specific ADP-ribose pyrophosphatase gene from the archaebacterium, Methanococcus jannaschii, introduced into E. coli, increased the transformant's tolerance to potassium tellurite. (+info)Mechanism of the ArsA ATPase. (6/104)
The ArsAB ATPase confers metalloid resistance in Escherichia coli by pumping toxic anions out of the cells. This transport ATPase shares structural and perhaps mechanism features with ABC transporters. The ArsAB pump is composed of a membrane subunit that has two groups of six transmembrane segments, and the catalytic subunit, the ArsA ATPase. As is the case with many ABC transporters, ArsA has an internal repeat, each with an ATP binding domain, and is allosterically activated by substrates of the pump. The mechanism of allosteric activation of the ArsA ATPase has been elucidated at the molecular level. Binding of the activator produces a conformational change that forms a tight interface of the nucleotide binding domains. In the rate-limiting step in the overall reaction, the enzyme undergoes a slow conformational change. The allosteric activator accelerates catalysis by increasing the velocity of this rate-limiting step. We postulate that similar conformational changes may be rate-limiting in the mechanism of ABC transporters. (+info)Trimeric ring-like structure of ArsA ATPase. (7/104)
ArsA protein is the soluble subunit of the Ars anion pump in the Escherichia coli membrane which extrudes arsenite or antimonite from the cytoplasm. The molecular weight of the subunit is 63 kDa. In the cell it hydrolyzes ATP, and the energy released is used by the membrane-bound subunit ArsB to transport the substrates across the membrane. We have obtained two-dimensional crystals of ArsA in the presence of arsenite on negatively-charged lipid monolayer composed of DMPS and DOPC. These crystals have been studied using electron microscopy of negatively-stained specimens followed by image processing. The projection map obtained at 2.4 nm resolution reveals a ring-like structure with threefold symmetry. Many molecular assemblies with the same ring-shape and dimensions were also seen dispersed on electron microscopy grids, prepared directly from purified ArsA protein solution. Size-exclusion chromatography of the protein sample with arsenite present revealed that the majority of the protein particles in solution have a molecular weight of about 180 kDa. Based on these experiments, we conclude that in solution the ArsA ATPase with substrate bound is mainly in a trimeric form. (+info)The chromosomal arsenic resistance genes of Thiobacillus ferrooxidans have an unusual arrangement and confer increased arsenic and antimony resistance to Escherichia coli. (8/104)
The chromosomal arsenic resistance genes of the acidophilic, chemolithoautotrophic, biomining bacterium Thiobacillus ferrooxidans were cloned and sequenced. Homologues of four arsenic resistance genes, arsB, arsC, arsH, and a putative arsR gene, were identified. The T. ferrooxidans arsB (arsenite export) and arsC (arsenate reductase) gene products were functional when they were cloned in an Escherichia coli ars deletion mutant and conferred increased resistance to arsenite, arsenate, and antimony. Therefore, despite the fact that the ars genes originated from an obligately acidophilic bacterium, they were functional in E. coli. Although T. ferrooxidans is gram negative, its ArsC was more closely related to the ArsC molecules of gram-positive bacteria. Furthermore, a functional trxA (thioredoxin) gene was required for ArsC-mediated arsenate resistance in E. coli; this finding confirmed the gram-positive ArsC-like status of this resistance and indicated that the division of ArsC molecules based on Gram staining results is artificial. Although arsH was expressed in an E. coli-derived in vitro transcription-translation system, ArsH was not required for and did not enhance arsenic resistance in E. coli. The T. ferrooxidans ars genes were arranged in an unusual manner, and the putative arsR and arsC genes and the arsBH genes were translated in opposite directions. This divergent orientation was conserved in the four T. ferrooxidans strains investigated. (+info)
arsC - Arsenate reductase - Acinetobacter variabilis - arsC gene & protein
Ars operon - Wikipedia
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial))
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Antimonite - definition of antimonite by The Free Dictionary
Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump | Biochemical Journal
ARSA Gene - GeneCards | ARSA Protein | ARSA Antibody
ARSA Gene - GeneCards | ARSA Protein | ARSA Antibody
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Arsenic in the structure of Arsenate Reductase+0.4M Arsenite From E. Coli (pdb 1j9b)
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ASNA1 and CACNA1A Interaction - Wiki-Pi
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List of EC numbers (EC 7)
... arsenite-transporting ATPase * * No Wikipedia article EC 7.4.2.1: ABC-type polar-amino-acid transporter * EC 7.4.2.2: ABC-type ... mitochondrial protein-transporting ATPase * EC 7.4.2.4: chloroplast protein-transporting ATPase * EC 7.4.2.5: bacterial ABC- ... H+-transporting) * EC 7.1.1.4: caldariellaquinol oxidase (H+-transporting) * EC 7.1.1.5: menaquinol oxidase (H+-transporting ... Na+-transporting two-sector ATPase * EC 7.2.2.2: ABC-type Cd2+ transporter * EC 7.2.2.3: P-type Na+ transporter * EC 7.2.2.4: ...
Arsenite-antimonite transporter
Arsenic toxicity Arsenite-transporting ATPase Solute carrier family Active transport ATP-binding cassette transporter Hasgekar ... Arsenite-antimonite transporters are membrane transporters that pump arsenite or antimonite out of a cell. Antimonite is the ... an ATPase, must be superimposed onto ArsB. Arsenite and antimonite can also be pumped out of the cell by members of the ARC3 ... which can participate in both secondary transport or primary active transport. Based on operon analyses, Arc3 homologues may ...
ArsB and ArsAB transporters
... superfamily ARC3 family Arsenite-Antimonite efflux Arsenite-transporting ATPase Solute carrier family Active transport ATP- ... Arsenite or Antimonite (out). The overall reaction catalyzed by ArsB-ArsA is: Arsenite or Antimonite (in) + ATP ⇌ Arsenite or ... "Families of soft-metal-ion-transporting ATPases". Journal of Bacteriology. 181 (19): 5891-7. doi:10.1128/JB.181.19.5891- ... Arsenite resistance (Ars) efflux pumps of bacteria may consist of two proteins, ArsB (TC# 2.A.45.1.1; the integral membrane ...
Arsenite-transporting ATPase
In enzymology, an arsenite-transporting ATPase (EC 3.6.3.16) is an enzyme that catalyzes the chemical reaction ATP + H2O + ... and arsenite, whereas its 3 products are ADP, phosphate, and arsenite. This enzyme belongs to the family of hydrolases, ... Arsenite-Antimonite efflux Silver S, Misra TK, Laddaga RA (1989). "DNA sequence analysis of bacterial toxic heavy metal ... The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting). As of late 2007, 3 structures have been ...
Transporter Classification Database
V-type ATPase and A-type ATPase superfamily 3.A.3 The P-type ATPase Superfamily 3.A.4 The Arsenite-Antimonite efflux family 3.A ... Family 3.B.1 The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family 3.C.1 The Na+ Transporting ... Family 1.D.58 The Anion Transporting Prodigiosene (Prodigiosene) Family 1.D.59 The Anion Transporting Perenosin (Perenosin) ... See electron transport chain. 3.D.1 The H+ or Na+-translocating NADH Dehydrogenase ("complex I") family 3.D.2 The Proton- ...
Ars operon
It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out ... thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion. Carlin A ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... ArsA and ArsB form an anion-translocating ATPase. The ArsB protein is distinguished by its overall hydrophobic character, in ...
ARC3 family
The Bacillus protein exports both arsenite and antimonite. The exact transport mechanism has not established. The generalized ... Homologous ATPases are found in families TC# 3.A.4, TC# 3.A.19 and TC# 3.A.21 as well as TC# 2.A.59. A region of the ABC ATPase ... In the latter case ATP hydrolysis again energizes transport. ARC3 homologues transport the same anions as ArsA/AB homologues, ... reaction catalyzed by members of the ACR3 family is: arsenite or antimonite (in) → arsenite or antimonite (out). Arsenite- ...
Neurotoxin
An underlying mechanism by which lead is able to cause harm is its ability to be transported by calcium ATPase pumps across the ... As a metabolite of arsenic, arsenite is formed after ingestion of arsenic and has shown significant toxicity to neurons within ... This is important as neurotransmitter transport can be impaired through vesicular transport inhibition, resulting in diminished ... This barrier creates a tight hydrophobic layer around the capillaries in the brain, inhibiting the transport of large or ...
List of EC numbers (EC 3)
Na+-transporting two-sector ATPase EC 3.6.3.16: Now EC 7.3.2.7, arsenite-transporting ATPase EC 3.6.3.17: Now covered by ... teichoic-acid-transporting ATPase EC 3.6.3.41: Now EC 7.6.2.5, heme-transporting ATPase EC 3.6.3.42: Now EC 7.5.2.3, β-glucan- ... fatty-acyl-CoA-transporting ATPase EC 3.6.3.48: Now EC 7.4.2.7 as α-factor-pheromone transporting ATPase EC 3.6.3.49: Now EC ... Na+/K+-exchanging ATPase EC 3.6.3.10: Now EC 7.2.2.19, H+/K+-exchanging ATPase EC 3.6.3.11: Cl--transporting ATPase. The ...
Stress granule
It has also been proposed that microtubules play a role in the formation of stress granules, perhaps by transporting granule ... Jain S, Wheeler JR, Walters RW, Agrawal A, Barsic A, Parker R (January 2016). "ATPase-Modulated Stress Granules Contain a ... June 2018). "ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules". ... In yeast, catalytic ded1 mutant alleles give rise to constitutive stress granules ATPase-deficient DDX3X (the mammalian homolog ...
Microbial metabolism
Protons are transported across the membrane by the initial NADH reductase, quinones, and nitrous oxide reductase to produce the ... In all cases, however, a proton motive force is generated and used to drive ATP production via an ATPase. Most photosynthetic ... reduction to arsenite (AsO3− 3) Uranyl ion ion (UO2+ 2) reduction to uranium dioxide (UO 2) A number of organisms, instead of ... This means that these organisms do not use an electron transport chain to oxidize NADH to NAD+ and therefore must have an ...
Variovorax paradoxus
... metal transporting P1-type ATPases and a chemiosmotic antiporter efflux system similar to CzcCBA of Cupriavidus metallidurans. ... MM-1 isolated from a soil and identification of arsenite oxidase gene". Journal of Hazardous Materials. 262: 997-1003. doi: ... Bahar, Md Mezbaul; Megharaj, Mallavarapu; Naidu, Ravi (2013-11-15). "Kinetics of arsenite oxidation by Variovorax sp. ...
HOMD :: SEQF1709
arsenite-activated ATPase ArsA. 196. SEQF1709,CP001215.1. ACP12161.1 jb [NA] [AA] 696/231. 1389919-1390614. putative membrane ... bacitracin transport permease. 20. SEQF1709,CP001214.1. ACP11984.1 jb [NA] [AA] 393/130. 18659-18267. hypothetical protein. ...
Mechanisms of arsenic toxicity and transport in microorganisms
gene product is an arsenite (antimonate)-stimulated ATPase. J. Biol. Chem. . 263. , 3067-3070 (1988). Search in Google Scholar ... gene encodes a putative membrane protein involved in arsenite transport. J. Biol. Chem. . 272. , 30061-30066 (1997). Search in ... Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces ... in rice enhanced arsenite efflux and reduced arsenic accumulation in rice grains. Plant Cell Physiol. . 53. , 154-163 (2012). ...
December | 2019 | PPAR Signaling
Kashyap DR, Botero LM, Franck WL, Hassett DJ, McDermott TR: Complex regulation of learn more arsenite oxidation by ... They include turgor and mechanical stress, ion or electrochemical gradients and transport processes. For find more instance, ... influence on ATPase activity and membrane fluidity. Mol Pharm ... of arsenic with detection and phylogenetic analysis of arsenite ... transport) and internal (cytoplasmatic solutes or proteins, redox state) conditions and integrate them. ...
Concentration Measurement Archives - Particle Metrix
ArseniteArsenite-induced Carcinogenesiscell cyclecirculting RNAExosomal circRNA_100284exosomeslivermalignant transformation ... AcidificationAtg5Autophagycancerendosomeexosomesextracellular vesiclesLC3multivesicular bodytumorV1V0-ATPase ... Fetal Membranes Contribute to Drug Transport across the Feto-Maternal Interface Utilizing the Breast Cancer Resistance Protein ... Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant ...
Sodium-Potassium-Exchanging ATPase | Profiles RNS
Vesicular Neurotransmitter Transport Proteins. *Cation Transport Proteins. *Arsenite Transporting ATPases. *Calcium- ... Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S. The alpha-1 subunit of the Na+,K+-ATPase ... "Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH ... An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ...
Bio2Vec
carboxylic acid-transporting ATPase activity GO:0033284 * L-ornithine transmembrane transporter activity ... arsenite secondary active transmembrane transporter activity GO:0008490 * succinate transmembrane transporter activity ...
CoP: Co-expressed Biological Processes
ECA3 (ENDOPLASMIC RETICULUM-TYPE CALCIUM-TRANSPORTING ATPASE 3). Encodes a golgi localized P2A-type Ca2+ ATPase involved in Mn ... Also functions in arsenite transport and tolerance.. O.I.. C.G.. H.G.. Please select. TAIR (integral). KEGG (integral). ... F:binding;P:transport, mitochondrial transport;C:mitochondrial inner membrane, membrane;MFPO. O.I.. C.G.. H.G.. Please select. ... F:RNA binding, nucleotide binding, nucleic acid binding;P:transport, nucleocytoplasmic transport;C:intracellular;MFPOBV. O.I.. ...
Xenopus | [email protected]
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Aven-dependent activation of ATM following DNA damage. ... Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner ... Nuclear transport kinetics in microarrays of nuclear envelope patches. * PP1 control of M phase entry exerted through 14-3-3- ...
Bio2Vec
polar-amino acid-transporting ATPase activity GO:0015426 * L-arginine-importing ATPase activity ... ATPase-coupled arsenite transmembrane transporter activity GO:0015446 * L-glutamate transmembrane transporter activity ...
Cloning, Molecular | [email protected]
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase ... MOP2 (SLA2) affects the abundance of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. ... The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear ... Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. ...
IMP: Integrative Multi-species Prediction
ATPase, H+ transporting, lysosomal accessory protein 1. 0.011. Vdac1. voltage-dependent anion channel 1. 0.011. ... arsA arsenite transporter, ATP-binding, homolog 1 (bacterial). 0.077. arf2. ADP-ribosylation factor 2. 0.076. ... The network for 'er to golgi vesicle mediated transport' in your query organism is displayed on the left, if relationships are ... er to golgi vesicle mediated transport. The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, ...
Enzyme
Arsenite methyltransferase. Arsenite-transporting ATPase. Aryl sulfotransferase. Aryl-acylamidase. Aryl-alcohol dehydrogenase. ... Alpha-factor-transporting ATPase. Alpha-galactosidase. Alpha-glucan,water dikinase. Alpha-glucosidase. Alpha-glucosiduronase. ... Ag(+)-exporting ATPase. Agarase. Agaritine gamma-glutamyltransferase. Agmatinase. Agmatine N(4)-coumaroyltransferase. Agmatine ...
Energetic evolution of cellular Transportomes | BMC Genomics | Full Text
Many transport processes are energetically expensive and the cells use 20 to 60% of their energy to power the transportomes. We ... Davies JM, Hunt I, Sanders D. Vacuolar H(+)-pumping ATPase variable transport coupling ratio controlled by pH. Proc Natl Acad ... and the arsenite-antimonite efflux families, generally show a 1:2 stoichiometry of substrate:ATP hydrolysis [103,104,105,106, ... Families of soft-metal-ion-transporting ATPases. J Bacteriol. 1999;181:5891-7. ...
MeSH Browser
ATPases Associated with Diverse Cellular Activities [D08.811.277.040.025.024] * Arsenite Transporting ATPases [D08.811.277.040. ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ...
AT4G32160 details
ATPase-coupled arsenite transmembrane transporter activity. IEP. Neighborhood. BP. GO:0015691. cadmium ion transport. IEP. ... xenobiotic transmembrane transporting ATPase activity. IEP. Neighborhood. MF. GO:0008641. ubiquitin-like modifier activating ... ATPase activity, coupled. IEP. Neighborhood. MF. GO:0042626. ATPase activity, coupled to transmembrane movement of substances. ... ATPase-coupled anion transmembrane transporter activity. IEP. Neighborhood. MF. GO:0043492. ATPase activity, coupled to ...
YJR139C 267.488705 INESSENTIAL HOM6 "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase),5-amino-6-(5...
... "vacuolar ATPase V0 domain subunit c (17 kDa), endocytosis*, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... "Putative membrane protein involved in arsenite transport,arsenite transporter, " YJL206C-A 2.973031 INESSENTIAL YMR065W 2.97168 ... "vacuolar ATPase V1 domain subunit D, vacuolar acidification, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... hydrogen-transporting two-sector ATPase, hydrogen-transporting ATPase V0 domain" YHR021W-A 0.568915 INESSENTIAL ECM12 "( ...
Arsenite-transporting ATPase - Wikipedia
In enzymology, an arsenite-transporting ATPase (EC 3.6.3.16) is an enzyme that catalyzes the chemical reaction ATP + H2O + ... and arsenite, whereas its 3 products are ADP, phosphate, and arsenite. This enzyme belongs to the family of hydrolases, ... Arsenite-Antimonite efflux Silver S, Misra TK, Laddaga RA (1989). "DNA sequence analysis of bacterial toxic heavy metal ... The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting). As of late 2007, 3 structures have been ...
Mechanisms of arsenic toxicity and transport in microorganisms
gene product is an arsenite (antimonate)-stimulated ATPase. J. Biol. Chem. . 263. , 3067-3070 (1988). Search in Google Scholar ... gene encodes a putative membrane protein involved in arsenite transport. J. Biol. Chem. . 272. , 30061-30066 (1997). Search in ... Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces ... in rice enhanced arsenite efflux and reduced arsenic accumulation in rice grains. Plant Cell Physiol. . 53. , 154-163 (2012). ...
Translocase: Enzyme Commission Class #7. - Holiday Recipes to Cook
Enzyme
Arsenite methyltransferase. Arsenite-transporting ATPase. Aryl sulfotransferase. Aryl-acylamidase. Aryl-alcohol dehydrogenase. ... Alpha-factor-transporting ATPase. Alpha-galactosidase. Alpha-glucan,water dikinase. Alpha-glucosidase. Alpha-glucosiduronase. ... Ag(+)-exporting ATPase. Agarase. Agaritine gamma-glutamyltransferase. Agmatinase. Agmatine N(4)-coumaroyltransferase. Agmatine ...
AT4G32160 details
ATPase-coupled arsenite transmembrane transporter activity. IEP. Neighborhood. BP. GO:0015691. cadmium ion transport. IEP. ... xenobiotic transmembrane transporting ATPase activity. IEP. Neighborhood. MF. GO:0008641. ubiquitin-like modifier activating ... ATPase activity, coupled. IEP. Neighborhood. MF. GO:0042626. ATPase activity, coupled to transmembrane movement of substances. ... ATPase-coupled anion transmembrane transporter activity. IEP. Neighborhood. MF. GO:0043492. ATPase activity, coupled to ...
SuCComBase
arsenite transport. The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent ... ATPase-coupled arsenite transmembrane transporter activity. Enables the transfer of a solute or solutes from one side of a ... Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a ... membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). ...
Sodium-Potassium-Exchanging ATPase | Profiles RNS
Vesicular Neurotransmitter Transport Proteins. *Cation Transport Proteins. *Arsenite Transporting ATPases. *Calcium- ... Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S. The alpha-1 subunit of the Na+,K+-ATPase ... "Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ...
MeSH Browser
ATPases Associated with Diverse Cellular Activities [D08.811.277.040.025.024] * Arsenite Transporting ATPases [D08.811.277.040. ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ...
RecQ Helicases | Profiles RNS
TCDB » Superfamilies
P-type ATPase (P-ATPase) Superfamily. Seventeen families of P-type ATPases are present under TC# 3.A.3. Thever, M.D. and M.H. ... The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS Journal 274(3):612-29. Chen, J.S., V. Reddy, J.H. Chen, M.A. ... 2007). Mercury Transport in Bacteria. Water, Air, and Soil Pollution. 182: 219 - 234. Timothy Mok, JS. Chen, MA. Shlykov, MH. ... 2010). The p-type ATPase superfamily. J. Mol. Microbiol. Biotechnol. 19: 5-104.. 3.A.3 - The P-type ATPase (P-ATPase) ...
IMP: Integrative Multi-species Prediction
Energetic evolution of cellular Transportomes | BMC Genomics | Full Text
Many transport processes are energetically expensive and the cells use 20 to 60% of their energy to power the transportomes. We ... Davies JM, Hunt I, Sanders D. Vacuolar H(+)-pumping ATPase variable transport coupling ratio controlled by pH. Proc Natl Acad ... and the arsenite-antimonite efflux families, generally show a 1:2 stoichiometry of substrate:ATP hydrolysis [103,104,105,106, ... Families of soft-metal-ion-transporting ATPases. J Bacteriol. 1999;181:5891-7. ...
DeCS
Arsenite Transporting ATPases [D08.811.277.040.025.047] Arsenite Transporting ATPases * Ca(2+) Mg(2+) ATPase [D08.811.277.040. ... ATPases associated with diverse cellular activities Synonymes. AAA ATPases AAA+ ATPases ATPases AAA ATPases AAA+ ATPases ... AAA ATPases. AAA Proteases. AAA+ ATPases. AAA+ Proteases. ATPases AAA. ATPases AAA+. ATPases associées a diverses activités ... ATPases associated with diverse cellular activities Descripteur en anglais: ATPases Associated with Diverse Cellular Activities ...
YJR139C 267.488705 INESSENTIAL HOM6 "Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase),5-amino-6-(5...
... "vacuolar ATPase V0 domain subunit c (17 kDa), endocytosis*, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... "Putative membrane protein involved in arsenite transport,arsenite transporter, " YJL206C-A 2.973031 INESSENTIAL YMR065W 2.97168 ... "vacuolar ATPase V1 domain subunit D, vacuolar acidification, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... hydrogen-transporting two-sector ATPase, hydrogen-transporting ATPase V0 domain" YHR021W-A 0.568915 INESSENTIAL ECM12 "( ...
Neurotoxin - Wikipedia
An underlying mechanism by which lead is able to cause harm is its ability to be transported by calcium ATPase pumps across the ... known function of arsenite is its destructive nature towards the cytoskeleton through inhibition of neurofilament transport.[47 ... This is important as neurotransmitter transport can be impaired through vesicular transport inhibition, resulting in diminished ... This barrier creates a tight hydrophobic layer around the capillaries in the brain, inhibiting the transport of large or ...
Bio2Vec
The Digital Ageing Atlas | Welle et al. (2003) 'Gene expression profile of aging in human muscle.' Physiol. Genomics 14(2):149...
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial). Molecular. skeletal muscle. Human. ASNA1. 4.0% Decrease Gene ... ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit. Molecular. skeletal muscle. Human. ATP5O. 2.0% Decrease ... AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast). Molecular. skeletal muscle. Human. AHSA2. 3.0% Increase ... ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9). Molecular. skeletal muscle. Human. ATP5G1. 4.0 ...
CoP: Co-expressed Biological Processes
ECA3 (ENDOPLASMIC RETICULUM-TYPE CALCIUM-TRANSPORTING ATPASE 3). Encodes a golgi localized P2A-type Ca2+ ATPase involved in Mn ... Also functions in arsenite transport and tolerance.. O.I.. C.G.. H.G.. Please select. TAIR (integral). KEGG (integral). ... F:binding;P:transport, mitochondrial transport;C:mitochondrial inner membrane, membrane;MFPO. O.I.. C.G.. H.G.. Please select. ... F:RNA binding, nucleotide binding, nucleic acid binding;P:transport, nucleocytoplasmic transport;C:intracellular;MFPOBV. O.I.. ...
Xenopus | [email protected]
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Aven-dependent activation of ATM following DNA damage. ... Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner ... Nuclear transport kinetics in microarrays of nuclear envelope patches. * PP1 control of M phase entry exerted through 14-3-3- ...
December | 2019 | PPAR Signaling
Kashyap DR, Botero LM, Franck WL, Hassett DJ, McDermott TR: Complex regulation of learn more arsenite oxidation by ... They include turgor and mechanical stress, ion or electrochemical gradients and transport processes. For find more instance, ... influence on ATPase activity and membrane fluidity. Mol Pharm ... of arsenic with detection and phylogenetic analysis of arsenite ... transport) and internal (cytoplasmatic solutes or proteins, redox state) conditions and integrate them. ...
IMP: Integrative Multi-species Prediction
ATPase, H+ transporting, lysosomal accessory protein 1. 0.011. Vdac1. voltage-dependent anion channel 1. 0.011. ... arsA arsenite transporter, ATP-binding, homolog 1 (bacterial). 0.077. arf2. ADP-ribosylation factor 2. 0.076. ... The network for er to golgi vesicle mediated transport in your query organism is displayed on the left, if relationships are ... er to golgi vesicle mediated transport. The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, ...
HOMD :: SEQF1709
Concentration Measurement Archives - Particle Metrix
ArseniteArsenite-induced Carcinogenesiscell cyclecirculting RNAExosomal circRNA_100284exosomeslivermalignant transformation ... AcidificationAtg5Autophagycancerendosomeexosomesextracellular vesiclesLC3multivesicular bodytumorV1V0-ATPase ... Fetal Membranes Contribute to Drug Transport across the Feto-Maternal Interface Utilizing the Breast Cancer Resistance Protein ... Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant ...
Biological Transport | [email protected]
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Ascites Increases Expression/Function of Multidrug ... The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction. ... Biological Transport * Subject Areas on Research. * 22Na+ and 86Rb+ transport in vascular smooth muscle of SHR, Wistar Kyoto, ... Cerebral glucose transport and metabolism in preterm human infants. * Cerebral transport and metabolism of 1-11C-D-glucose ...
Subunit1
- Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S. The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. (uams.edu)
Transporter1
- The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. (plant-scc.org)
Phosphate2
- In enzymology, an arsenite-transporting ATPase (EC 3.6.3.16) is an enzyme that catalyzes the chemical reaction ATP + H2O + arsenitein ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + arseniteout The 3 substrates of this enzyme are ATP, H2O, and arsenite, whereas its 3 products are ADP, phosphate, and arsenite. (wikipedia.org)
- Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). (plant-scc.org)
Amino Acids1
- The APC superfamily consists of numerous families of porters that transport amino acids and their dereivatives. (tcdb.org)
Efflux3
- Arsenite-Antimonite efflux Silver S, Misra TK, Laddaga RA (1989). (wikipedia.org)
- In this article, we review recent advances in the understanding of arsenic toxicity and its transport routes in prokaryotes and eukaryotes, including a dual role of aquaglyceroporins in the uptake and efflux, active transport out of the cell via secondary ion pumps and sequestration of metalloid-thiol conjugates into vacuoles by primary ABC transporters. (sciendo.com)
- The action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. (or.jp)
Sodium6
- S)-methylmalonyl-CoA decarboxylase (sodium-transporting). (holidayrecipestocook.com)
- Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
- An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. (uams.edu)
- Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (uams.edu)
- This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in UAMS Profiles by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications. (uams.edu)
- Below are the most recent publications written about "Sodium-Potassium-Exchanging ATPase" by people in Profiles over the past ten years. (uams.edu)
Enzyme1
- The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting). (wikipedia.org)
Protein4
- chloroplast protein-transporting ATPase. (holidayrecipestocook.com)
- protein-secreting ATPase. (holidayrecipestocook.com)
- These ATPase are found as coomponents of several protein secretion systems as well as synaptosomal fusion systems. (tcdb.org)
- Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. (tcdb.org)
Structures1
- Larger structures are transported along microtubules to the cis-Golgi. (princeton.edu)
Cellular1
- Additionally, the presence of substrate-binding proteins as the partners of a subset of membrane transporters [ 13 ] makes the cellular transport machinery more complicated than if we consider only the transporters themselves. (biomedcentral.com)
Functions1
- A large highly-conserved family of ATPases with diverse functions in cells that are characterized by the presence of a P-LOOP and a ring shape. (bvsalud.org)
Large1
- This barrier creates a tight hydrophobic layer around the capillaries in the brain, inhibiting the transport of large or hydrophilic compounds. (wikipedia.org)
Cells2
- Many transport processes are energetically expensive and the cells use 20 to 60% of their energy to power the transportomes. (biomedcentral.com)
- Thus, protective cells termed astrocytes surround the capillaries in the brain and absorb nutrients from the blood and subsequently transport them to the neurons, effectively isolating the brain from a number of potential chemical insults. (wikipedia.org)
Specific1
- Root-specific role in the transport of auxin. (or.jp)
Process1
- Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. (plant-scc.org)
Superfamily2
Antimonite1
- also transports arsenite (As(III) and antimonite (Sb(III)) (Meng et al. (lbl.gov)
Serine1
- TauE14 is a pseudohyperphosphorylated mutant transporting 14 phosphomimetic (serine/threonine to glutamate) mutations22, which mimic hyperphosphorylation, a known driver of Tau misfolding and aggregation in AD and other tauopathies. (sc-scied.org)
Strains5
- The goal of the present study was to analyze the transport proteins in seven Bacteroides strains. (bestprobioticsforibs.com)
- These seven strains were examined for analysis of the distributions of single and multicomponent transport systems and their substrates. (bestprobioticsforibs.com)
- As example we present partial relations between a cluster of four genes of strain MG1363 (and their orthologs in query strains) and arsenite resistance (Figure 3B). (bcl-2inhibitors.com)
- These genes were found to be relevant for check details strains growing at 0.9625 mM of arsenite and are present in most of the highly resistant strains. (bcl-2inhibitors.com)
- Visualizing BIRB 796 occurrence of these genes in strains revealed that they are mostly absent in strains with no arsenite resistance phenotype and mostly present in strains with mild or high arsenite resistance phenotypes (Figure 3C). (bcl-2inhibitors.com)
Proteins4
- Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. (tcdb.org)
- The human genome encodes at least 1500 RNA binding proteins (RBPs) that regulate RNA metabolism from biogenesis to transport, localization and degradation, therefore playing a crucial role in cellular homeostasis1,2. (sc-scied.org)
- Zafar H, Saier MH Jr (2018) Comparative genomics of transport proteins in seven Bacteroides species. (bestprobioticsforibs.com)
- The research reported in the present communication is a continuation of a series of studies on the transport proteins in gut commensals and pathogens. (bestprobioticsforibs.com)
Mechanisms2
- Thus, comprehending the mechanisms of water transport is essential to understanding mammalian kidney physiology and water balance. (abdominalkey.com)
- However, these species have acquired alternative mechanisms to transport sugars into the cells and phosphorylate them [ 10 ]. (bestprobioticsforibs.com)
Role2
- 2004). Oligomerization may play a role in determining the rate of transport. (lbl.gov)
- download violence and warfare of Glutaredoxin1 and Glutathione in including the Role of the Copper-transporting P-type ATPases, ATP7A and ATP7B. (peacefulspiritmassage.com)
System1
- An interesting facet of the physiology of Bacteroides is the absence of transport-linked phosphorylation systems of the phosphotransferase system (PTS) [ 9 ]. (bestprobioticsforibs.com)
Arsenate1
- Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. (nih.gov)
Intracellular1
- They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions. (nih.gov)
Sodium:potassium3
- Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in this website by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Sodium-Potassium-Exchanging ATPase" by people in Profiles. (uchicago.edu)
Ions2
- An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. (uchicago.edu)
- Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (uchicago.edu)
Pump1
- Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. (nih.gov)
Coli1
- We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomyces cerevisiae Fps1p, AQP7, and AQP9 from rat and human, conduct trivalent inorganic arsenic [As(III)] as arsenic trioxide, the protonated form of arsenite. (nih.gov)
Chemical1
- that is, ATP is able to store and transport chemical energy within cells. (drugbank.com)
Activity1
- The arsenite production reaction of thymidine phosphorylase had approximately 5% of such PNP activity. (nih.gov)
MITOCHONDRIA1
- Although the specific causal mechanism of doxorubicin-induced cardiotoxicity remains largely unclear, most of the evidence has indicated that doxorubicin is reduced to its semiquinone form by a mitochondria electron transport system. (biomedcentral.com)
Target2
- For investigators to understand the mechanisms of arsenic toxicity and carcinogenesis as well as the ability of arsenic to serve as a chemotherapeutic agent, it is important to determine how methylated arsenicals are transported out of the liver and how they enter target tissues. (nih.gov)
- Orlov SN, La J, Smolyaninova LV, Dulin NO. Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis. (uchicago.edu)