Inorganic salts or organic esters of arsenious acid.
Inorganic compounds that contain sodium as an integral part of the molecule.
Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions.
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
Inorganic or organic salts and esters of arsenic acid.
A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
Multisubunit enzymes that reversibly synthesize ADENOSINE TRIPHOSPHATE. They are coupled to the transport of protons across a membrane.
Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. They differ from CALCIUM CHANNELS which allow calcium to pass through a membrane without the use of energy.
Proton-translocating ATPases that are involved in acidification of a variety of intracellular compartments.
A general class of integral membrane proteins that transport ions across a membrane against an electrochemical gradient.
A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
An agent that causes the production of physical defects in the developing embryo.
Oxidoreductases that specifically reduce arsenate ion to arsenite ion. Reduction of arsenate is a critical step for its biotransformation into a form that can be transported by ARSENITE TRANSPORTING ATPASES or complexed by specific sulfhydryl-containing proteins for the purpose of detoxification (METABOLIC DETOXIFICATION, DRUG). Arsenate reductases require reducing equivalents such as GLUTAREDOXIN or AZURIN.
Inorganic or organic compounds that contain arsenic.
Calcium-transporting ATPases found on the PLASMA MEMBRANE that catalyze the active transport of CALCIUM from the CYTOPLASM into the extracellular space. They play a role in maintaining a CALCIUM gradient across plasma membrane.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.
A schistosomicide possibly useful against other parasites. It has irritant emetic properties and may cause lethal cardiac toxicity among other adverse effects.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Membrane proteins whose primary function is to facilitate the transport of positively charged molecules (cations) across a biological membrane.
The type species of gram negative bacteria in the genus ALCALIGENES, found in soil. It is non-pathogenic, non-pigmented, and used for the production of amino acids.
A large group of bacteria including those which oxidize ammonia or nitrite, metabolize sulfur and sulfur compounds, or deposit iron and/or manganese oxides.
A family in the order Chromatiales, class GAMMAPROTEOBACTERIA. These are haloalkaliphilic, phototrophic bacteria that deposit elemental sulfur outside their cells.
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
A species of extremely thermophilic, sulfur-reducing archaea. It grows at a maximum temperature of 95 degrees C. in marine or deep-sea geothermal areas.
Any spaces or cavities within a cell. They may function in digestion, storage, secretion, or excretion.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Integral membrane proteins that transport protons across a membrane. This transport can be linked to the hydrolysis of ADENOSINE TRIPHOSPHATE. What is referred to as proton pump inhibitors frequently is about POTASSIUM HYDROGEN ATPASE.
A plant genus of the family PTERIDACEAE. Members contain entkaurane DITERPENES. The name is similar to bracken fern (PTERIDIUM).
Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
A cadmium halide in the form of colorless crystals, soluble in water, methanol, and ethanol. It is used in photography, in dyeing, and calico printing, and as a solution to precipitate sulfides. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
The rate dynamics in chemical or physical systems.
The process of cleaving a chemical compound by the addition of a molecule of water.
A genus in the family BURKHOLDERIACEAE, comprised of many species. They are associated with a variety of infections including MENINGITIS; PERITONITIS; and URINARY TRACT INFECTIONS.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Oxyvanadium ions in various states of oxidation. They act primarily as ion transport inhibitors due to their inhibition of Na(+)-, K(+)-, and Ca(+)-ATPase transport systems. They also have insulin-like action, positive inotropic action on cardiac ventricular muscle, and other metabolic effects.
A family of gram-negative bacteria in the class BETAPROTEOBACTERIA. There are at least eight genera.
A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.
Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Expression cloning for arsenite-resistance resulted in isolation of tumor-suppressor fau cDNA: possible involvement of the ubiquitin system in arsenic carcinogenesis. (1/104)

Arsenic is a human carcinogen whose mechanism of action is unknown. Previously, this laboratory demonstrated that arsenite acts as a comutagen by interfering with DNA repair, although a specific DNA repair enzyme sensitive to arsenite has not been identified. A number of stable arsenite-sensitive and arsenite-resistant sublines of Chinese hamster V79 cells have now been isolated. In order to gain understanding of possible targets for arsenite's action, one arsenite-resistant subline, As/R28A, was chosen as a donor for a cDNA expression library. The library from arsenite-induced As/R28A cells was transfected into arsenite-sensitive As/S5 cells, and transfectants were selected for arsenite-resistance. Two cDNAs, asr1 and asr2, which confer arsenite resistance to arsenite-hypersensitive As/S5 cells as well as to wild-type cells, were isolated. asr1 shows almost complete homology with the rat fau gene, a tumor suppressor gene which contains a ubiquitin-like region fused to S30 ribosomal protein. Arsenite was previously shown to inhibit ubiquitin-dependent proteolysis. These results suggest that the tumor suppressor fau gene product or some other aspect of the ubiquitin system may be a target for arsenic toxicity and that disruption of the ubiquitin system may contribute to the genotoxicity and carcinogenicity of arsenite.  (+info)

Asp45 is a Mg2+ ligand in the ArsA ATPase. (2/104)

The ATPase activity of ArsA, the catalytic subunit of the plasmid-encoded, ATP-dependent extrusion pump for arsenicals and antimonials in Escherichia coli, is allosterically activated by arsenite or antimonite. Magnesium is essential for ATPase activity. To examine the role of Asp45, mutants were constructed in which Asp45 was changed to Glu, Asn, or Ala. Cells expressing these mutated arsA genes lost arsenite resistance to varying degrees. Purified D45A and D45N enzymes were inactive. The purified D45E enzyme exhibited approximately 5% of the wild type activity with about a 5-fold decrease in affinity for Mg2+. Intrinsic tryptophan fluorescence was used to probe Mg2+ binding. ArsA containing only Trp159 exhibited fluorescence enhancement upon the addition of MgATP, which was absent in D45N and D45A. As another measure of conformation, limited trypsin digestion was used to estimate the surface accessibility of residues in ArsA. ATP and Sb(III) synergistically protected wild type ArsA from trypsin digestion. Subsequent addition of Mg2+ increased trypsin sensitivity. D45N and D45A remained protected by ATP and Sb(III) but lost the Mg2+ effect. D45E exhibited an intermediate Mg2+ response. These results indicate that Asp45 is a Mg2+-responsive residue, consistent with its function as a Mg2+ ligand.  (+info)

The ATPase mechanism of ArsA, the catalytic subunit of the arsenite pump. (3/104)

The ArsA ATPase is the catalytic subunit of a novel arsenite pump, with two nucleotide-binding consensus sequences in the N- and C-terminal halves of the protein. The single tryptophan-containing Trp159 ArsA was used to elucidate the elementary steps of the ATPase mechanism by fluorescence stopped-flow experiments. The binding and hydrolysis of MgATP is a multistep process with a minimal kinetic mechanism (Mechanism 1). A notable feature of the reaction is that MgATP binding induces a slow transient increase in fluorescence of ArsA, which is independent of the ATP concentration, indicative of the build-up of a pre-steady state intermediate. This finding, coupled with a phosphate burst, implies that the steady-state intermediate builds up subsequent to product release. We propose that the rate-limiting step is an isomerization between different conformational forms of ArsA. kcat is faster than the phosphate burst, indicating that both nucleotide binding sites of ArsA are catalytic. Consistent with this interpretation, approximately 2 mol of phosphate are released per mole of ArsA during the phosphate burst.  (+info)

The anion-stimulated ATPase ArsA shows unisite and multisite catalytic activity. (4/104)

ArsA, an anion-stimulated ATPase, consists of two nucleotide binding domains, A1 in the N terminus and A2 in the C terminus of the protein, connected by a linker. The A1 domain contains a high affinity ATP binding site, whereas the A2 domain has low affinity and it requires the allosteric ligand antimonite for binding ATP. ArsA is known to form a UV-activated adduct with [alpha-(32)P]ATP in the linker region. This study shows that on addition of antimonite, much more adduct is formed. Characterization of the nature of the adduct suggests that it is between ArsA and ADP, instead of ATP, indicating that the adduct formation reflects hydrolysis of ATP. The present study also demonstrates that the A1 domain is capable of carrying out unisite catalysis in the absence of antimonite. On addition of antimonite, multisite catalysis involving both A1 and A2 sites occurs, resulting in a 40-fold increase in ATPase activity. Studies with mutant proteins suggest that the A2 site may be second in the sequence of events, so that its role in catalysis is dependent on a functional A1 site. It is also proposed that ArsA goes through an ATP-bound and an ADP-bound conformation, and the linker region, where ADP binds under both unisite and multisite catalytic conditions, may play an important role in the energy transduction process.  (+info)

Studies on the ADP-ribose pyrophosphatase subfamily of the nudix hydrolases and tentative identification of trgB, a gene associated with tellurite resistance. (5/104)

Four Nudix hydrolase genes, ysa1 from Saccharomyces cerevisiae, orf209 from Escherichia coli, yqkg from Bacillus subtilis, and hi0398 from Hemophilus influenzae were amplified, cloned into an expression vector, and transformed into E. coli. The expressed proteins were purified and shown to belong to a subfamily of Nudix hydrolases active on ADP-ribose. Comparison with other members of the subfamily revealed a conserved proline 16 amino acid residues downstream of the Nudix box, common to all of the ADP-ribose pyrophosphatase subfamily. In this same region, a conserved tyrosine designates another subfamily, the diadenosine polyphosphate pyrophosphatases, while an array of eight conserved amino acids is indicative of the NADH pyrophosphatases. On the basis of these classifications, the trgB gene, a tellurite resistance factor from Rhodobacter sphaeroides, was predicted to designate an ADP-ribose pyrophosphatase. In support of this hypothesis, a highly specific ADP-ribose pyrophosphatase gene from the archaebacterium, Methanococcus jannaschii, introduced into E. coli, increased the transformant's tolerance to potassium tellurite.  (+info)

Mechanism of the ArsA ATPase. (6/104)

The ArsAB ATPase confers metalloid resistance in Escherichia coli by pumping toxic anions out of the cells. This transport ATPase shares structural and perhaps mechanism features with ABC transporters. The ArsAB pump is composed of a membrane subunit that has two groups of six transmembrane segments, and the catalytic subunit, the ArsA ATPase. As is the case with many ABC transporters, ArsA has an internal repeat, each with an ATP binding domain, and is allosterically activated by substrates of the pump. The mechanism of allosteric activation of the ArsA ATPase has been elucidated at the molecular level. Binding of the activator produces a conformational change that forms a tight interface of the nucleotide binding domains. In the rate-limiting step in the overall reaction, the enzyme undergoes a slow conformational change. The allosteric activator accelerates catalysis by increasing the velocity of this rate-limiting step. We postulate that similar conformational changes may be rate-limiting in the mechanism of ABC transporters.  (+info)

Trimeric ring-like structure of ArsA ATPase. (7/104)

ArsA protein is the soluble subunit of the Ars anion pump in the Escherichia coli membrane which extrudes arsenite or antimonite from the cytoplasm. The molecular weight of the subunit is 63 kDa. In the cell it hydrolyzes ATP, and the energy released is used by the membrane-bound subunit ArsB to transport the substrates across the membrane. We have obtained two-dimensional crystals of ArsA in the presence of arsenite on negatively-charged lipid monolayer composed of DMPS and DOPC. These crystals have been studied using electron microscopy of negatively-stained specimens followed by image processing. The projection map obtained at 2.4 nm resolution reveals a ring-like structure with threefold symmetry. Many molecular assemblies with the same ring-shape and dimensions were also seen dispersed on electron microscopy grids, prepared directly from purified ArsA protein solution. Size-exclusion chromatography of the protein sample with arsenite present revealed that the majority of the protein particles in solution have a molecular weight of about 180 kDa. Based on these experiments, we conclude that in solution the ArsA ATPase with substrate bound is mainly in a trimeric form.  (+info)

The chromosomal arsenic resistance genes of Thiobacillus ferrooxidans have an unusual arrangement and confer increased arsenic and antimony resistance to Escherichia coli. (8/104)

The chromosomal arsenic resistance genes of the acidophilic, chemolithoautotrophic, biomining bacterium Thiobacillus ferrooxidans were cloned and sequenced. Homologues of four arsenic resistance genes, arsB, arsC, arsH, and a putative arsR gene, were identified. The T. ferrooxidans arsB (arsenite export) and arsC (arsenate reductase) gene products were functional when they were cloned in an Escherichia coli ars deletion mutant and conferred increased resistance to arsenite, arsenate, and antimony. Therefore, despite the fact that the ars genes originated from an obligately acidophilic bacterium, they were functional in E. coli. Although T. ferrooxidans is gram negative, its ArsC was more closely related to the ArsC molecules of gram-positive bacteria. Furthermore, a functional trxA (thioredoxin) gene was required for ArsC-mediated arsenate resistance in E. coli; this finding confirmed the gram-positive ArsC-like status of this resistance and indicated that the division of ArsC molecules based on Gram staining results is artificial. Although arsH was expressed in an E. coli-derived in vitro transcription-translation system, ArsH was not required for and did not enhance arsenic resistance in E. coli. The T. ferrooxidans ars genes were arranged in an unusual manner, and the putative arsR and arsC genes and the arsBH genes were translated in opposite directions. This divergent orientation was conserved in the four T. ferrooxidans strains investigated.  (+info)

p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class=publication>Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href=http://www.nrbook.com/b/bookcpdf.php>Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
In molecular biology, the ars operon is an operon found in several bacterial taxon. It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out of the cell. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite before it is extruded. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance. ArsC is an approximately 150-residue arsenate reductase that uses reduced glutathione (GSH) to convert arsenate to arsenite with a redox active cysteine residue in the active site. ArsC forms an active quaternary complex with GSH, arsenate, and glutaredoxin 1 (Grx1). The three ligands must be present simultaneously for reduction to occur. ArsA and ArsB form an anion-translocating ATPase. The ArsB protein is distinguished by its overall hydrophobic ...
ASNA1 (arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
This study shows a critical role for Asna1 in ensuring β-cell function. Loss of Asna1 in β-cells of mice results in pancreatic hypoinsulinemia, impaired insulin secretion, and early onset diabetes. Additionally, β-cells of Asna1β−/− mice showed impaired PM-to-TGN as well as Golgi-to-ER retrograde transport, ER stress, and mislocalization of Stx5 and Stx6. Of note, we also show that inhibition of retrograde transport at the level of EE-to-TGN in isolated islet and insulinoma cells results in impaired Golgi-to-ER retrograde transport, decreased insulin content, and ER stress. Thus, the findings provide evidence that Asna1 is required in β-cells to ensure retrograde transport, which in turn appears to be essential for ER homeostasis and proinsulin biogenesis. Additionally, the perturbed Golgi-to-ER retrograde transport in Retro-2-treated primary islets suggests that the impairment of this step in Asna1β−/− β-cells likely is secondary to the inhibition of retrograde transport at the ...
Anti-human ASNA1 mAb, clone PAT2A1AT, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c immunized mice.
Sočasna okužba, sookužba ali koinfekcija je hkratna okužba celice ali organizma z dvema mikroorganizmoma (na primer pljučnica, ki jo povzročata ortomiksovirus in streptokok).[1] Kadar pa se nova okužba pridruži že obstoječi kasneje in ne istočasno, govorimo o nadokužbi (naknadni okužbi).[2] V svetovnem merilu je pogosta sookužba z jetiko (tuberkulozo) in HIV-om. V nekaterih državah je do 80 % bolnikov s tuberkulozo okuženih tudi z virusom HIV.[3] Nadalje je okoli 10 % bolnikov, okuženih s HIV-om, sočasno okuženih tudi z virusom hepatitisa B.[4] Pri okužbi s HIV-om pa je možna tudi sookužba z več sevi istega virusa; kadar pa se bolnik najprej okuži z enim sevom virusa, kasneje v življenju pa še z drugim, gre za nadokužbo.[5] ...
Tail-anchored (TA) proteins are a unique class of functionally diverse membrane proteins defined by their single C-terminal membrane-spanning domain and their ability to insert post-translationally into specific organelles with an Ncytoplasm-Corganelle interior orientation. The molecular mechanisms …
Słowa kluczowe: leczenie przewlekłych zapaleń tkanek okołowierzchołkowych, preparaty wodorotlenkowapniowe. W leczeniu przewlekłych zapaleń tkanek okołowierzchołkowych istotne jest działanie bakteriobójcze oraz stworzenie warunków do reparacji uszkodzonej kości. Najbardziej skuteczną metodą terapeutyczną okazało się biomechaniczne opracowanie kanału oraz zastosowanie wkładki leczniczej z wodorotlenku wapnia. Celem pracy była własna ocena wpływu nie twardniejących preparatów wodorotlenkowapniowych (Calxyl, Biopulp) na procesy gojenia i odnowy kości w przewlekłych zapaleniach przyzębia przyszczytowego. Leczeniem objęto 96 zębów jedno- i wielokorzeniowych. Na podstawie diagnostycznych zdjęć rtg ustalono średnicę zmian zapalnych. Wyodrębniono ogniska o średnicy do 3 mm, od 3 do 6 mm i powyżej 6 mm. Wkładki lecznicze z preparatów wodorotlenkowapniowych zmieniano co 3 miesiące. Obserwacje radiologiczne przeprowadzono po 3, 6, 9 i 12 miesiącach. Ogółem na 96 ...
Pogosti stranski učinki so povezani z antiholinergičnim delovanjem na parasimpatične postsinaptične receptorje: suha usta, grlo, nos, ob prekomernih odmerkih oslabljen govor, ki se lahko stopnjuje do mrmranja, podobnega glasovom rakuna; žeja, zamegljen vid in občutljivost na svetlobo, zaprtje, težave pri uriniranju in tahikardija. Ostali stranski učinki: pordelost, povišana temperatura, razburjenje, nemirnost, halucinacije, delirij, sploh pri višjih odmerkih. Našteti stranski učinki nastopijo ob peroralni ali parenteralni aplikaciji učinkovine, ne pa ob topični ali okularni uporabi. Ekstremni zaplet ob zaužitju zelo visokih odmerkov skopolamina in sorodnih drog je začasna slepota, ki lahko traja do 72 ur.. Vročina in izsušitev zaradi skopolamina lahko prisilita uporabnike tega mamila, da se poskušajo ohladiti v različnih vodnih zajetjih in se tam utopijo.. Stranski učinki skopolamina se lahko zamenjajo za simptome raka zaradi prisotne slabosti in različno velikih zenic ...
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Plasmid pIS1 mINSIG2 from Dr. David Bartels lab contains the insert INSIG2 3UTR and mutated miR-155 binding site and is published in Mol Cell. 2014 Mar 20;53(6):1031-43. doi: 10.1016/j.molcel.2014.02.013. Epub 2014 Mar 13. This plasmid is available through Addgene.
Define antimonite. antimonite synonyms, antimonite pronunciation, antimonite translation, English dictionary definition of antimonite. n an oxyanion of antimony or a salt containing an oxyanion of antimonya mineral from which antimony is obtained
The ArsA ATPase is the catalytic subunit of the pump protein, coupling the hydrolysis of ATP to the movement of arsenicals and antimonials through the membrane-spanning ArsB protein. Previously, we have shown the binding and hydrolysis of MgATP to ArsA to be a multi-step process in which the rate-limiting step is an isomerization between different conformational forms of ArsA. This isomerization occurs after product release, at the end of the ATPase reaction, and involves the return of the ArsA to its original conformation, which can then bind MgATP. ArsA possesses an allosteric site for antimonite [Sb(III)], the binding of which elevates the steady-state ATPase activity. We have used a transient kinetics approach to investigate the kinetics of ternary complex formation that lead to an enhancement in the ATPase activity. These studies revealed that ArsA exists in at least two conformational forms that differ in their ligand binding affinities, and that ATP favours one form and Sb(III) the other. ...
Complete information for ARSA gene (Protein Coding), Arylsulfatase A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for ARSA gene (Protein Coding), Arylsulfatase A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Gentaur molecular products has all kinds of products like :search , Zyagen \ ASNA1 Mouse Monoclonal Antibody \ APO-000439-M03 for more molecular products just contact us
Company Name: American Security Resources Corp., Stock Symbol: ARSC, Industry: Alternative Energy, Total Posts: 51817, Last Post: 1/13/2018 1:39:05 PM
Najem samochodów dostawczych w Warszawie jakkolwiek usługa idealnie skrojona na ilość potrzeb współczesnego Konsumenta! Stolica jest stroną, w jakiej idzie relatywnie sporo wypożyczalni wypożyczalnia aut dostawczych warszawa (click https://hellogoodbyethankyou.tumblr.com/), natomiast ich mężczyznami są nie tylko przybywający tu w handlach biznesmeni, jakkolwiek dodatkowo zwykli obywatele Najważniejszym mieście, jacy wymagają samochodu naprawdę rzadko, iż nie finansuje im się umieć go na cecha - po prostu w razie sprawy go wynajmują. Jesteśmy skupieni na nowoczesnym, aby dać Państwu kompletne szczęście - niezależnie od aktualnego, lub potrzebują Państwo zdecydować się na wynajem krótkoterminowy, średnioterminowy albo i długoterminowy, własna oferta zawsze stanowi efektywna a będzie ekskluzywnym wsparciem niezależnie z robionej poprzez Państwa działalności. Interes prowadzi także możliwość rezerwacji telefonicznej, i swej w lokalnej wypożyczalni ...
Plasmid pIS0 - HOXB8 3UTR from Dr. David Bartels lab contains the insert HOXB8 3UTR and is published in Science. 2004 Apr 23. 304(5670):594-6. This plasmid is available through Addgene.
대구광역시 동구 동내로 64 (동내동 1119) KERIS빌딩 우)41061 고객센터 (평일 09:00~18:00) 1599-3122 [ARS 번호 안내] ...
대구광역시 동구 동내로 64 (동내동 1119) KERIS빌딩 우)41061 고객센터 (평일 09:00~18:00) 1599-3122 [ARS 번호 안내] ...
Mono- and Stereopictres of 5.0 Angstrom coordination sphere of Arsenic atom in PDB 1j9b: Arsenate Reductase+0.4M Arsenite From E. Coli
Directory. Start here to access encyclopedic information about the worm genome and its genes, proteins, and other encoded features… Find out more. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Goat polyclonal antibody raised against synthetic peptide of ARSB. A synthetic peptide corresponding to human ARSB. (PAB7369) - Products - Abnova
Arsa - mouse gene knockout kit via CRISPR, 1 kit. |dl||dt|Kit Component:|/dt||dd|- |strong|KN301623G1|/strong|, Arsa gRNA vector 1 in |a href=http://www.origene.com/CRISPR-CAS9/Detail.
Vogl, C.; Panou, I.; Yamanbaeva, G.; Wichmann, C.; Mangosing, S. J.; Vilardi, F.; Indzhykulian, A. A.; Pangršič, T.; Santarelli, R.; Rodriguez-Ballesteros, M. et al.; Weber, T.; Jung, S.; Cardenas, E.; Wu, X.; Wojcik, S. M.; Kwan, K. Y.; Del Castillo, I.; Schwappach, B.; Strenzke, N.; Corey, D. P.; Lin, S. Y.; Moser, T.: Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. The EMBO Journal 35 (23), pp. 2536 - 2552 (2016 ...
ARSB Antibody 13227-1-AP has been identified with ELISA, WB, IHC. 13227-1-AP detected 44kd band in HepG2 cells with 1:500-1:1000 dilution...
Human ARSA partial ORF ( AAH14210, 398 a.a. - 507 a.a.) recombinant protein with GST-tag at N-terminal. (H00000410-Q01) - Products - Abnova
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Vina iz vinske regije Šampanja so bila znana pred srednjim vekom. Rimljani so bili prvi, ki so na tem območju severovzhodne Francije zasadili vinograde, pri čemer se je območje začasno obdelovalo v 5. stoletju. Pravzaprav je bila pridelava sprva počasna zaradi nepopularnega ukaza cesarja Domicijana, da mora biti vsa kolonialna trta izkoreninjena. Ko je cesar Prob, sin vrtnarja, razveljavil edikt, je bil postavljen tempelj Bakhu in regija je začela proizvajati rdeče, svetlo in sadno vino, ki je bilo v nasprotju s težjimi italijanskimi mešanicami, ki so bile pogosto obogatene s smolo in zelišči. [4] Kasneje so cerkve posedovale vinograde in menihi so proizvajali vino za uporabo v zakramentu evharistije. Francoski kralji so bili tradicionalno maziljeni v Reimsu in šampanjec je služil kot del kronanja. Šampanjčani so zavidali slovesu vin, ki so jih na jugu izdelovali burgundski sosedje, in so poskušali proizvajati vina enakega kakovosti. Severno podnebje v regiji pa je dalo ...
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When relubricating bearings from the side in housings with V-ring seals, mount an additional V-ring inside the housing on the side where grease is applied (fig. 5). This forces the grease to travel through the bearing and exit the housing on the opposite side.. SKF can supply an appropriate V-ring together with a splash plate that fits in the seal groove to cover a bit more than the top half of the housing. The sets are identified by the series designation ASNA followed by the housing size identification and the suffix V, e.g. ASNA 3024 V, and are available from size 3024 to 3032.. ...
When relubricating bearings from the side in housings with V-ring seals, mount an additional V-ring inside the housing on the side where grease is applied (fig. 5). This forces the grease to travel through the bearing and exit the housing on the opposite side.. SKF can supply an appropriate V-ring together with a splash plate that fits in the seal groove to cover a bit more than the top half of the housing. The sets are identified by the series designation ASNA followed by the housing size identification and the suffix V, e.g. ASNA 3024 V, and are available from size 3024 to 3032.. ...
Resumen Introducci n: Reportes en la literatura muestran que los Hijos de Padres con Trastorno Bipolar tipo I (HPTB) manifiestan un amplio rango de trastornos psiqui tricos. La comparaci n entre los HPTB y los Hijos de Padres Control (HPC) permite establecer cu les hallazgos psicopatol gicos son espec ficos de este grupo de alto riesgo. Objetivo: Comparar las caracter sticas psicopatol gicas entre un grupo de HPTB tipo I y un grupo de HPC, mediante la identificaci n de la presencia de trastornos psiqui tricos seg n el DSM-IV-TR. Metodolog a: Se realiz un estudio descriptivo-correlacional, comparativo de corte transversal con 127 Hijos de Padres con TAB tipo I (HPTB-I) dentro de un programa de intervenci n multimodal (PRISMA) y 150 HPC, con edades entre los seis y 30 a os. Los sujetos fueron evaluados con entrevistas diagn sticas validados (K-SADS-PL y DIGS). Resultados: El grupo de HPTB mostr mayor frecuencias de trastorno bipolar (Raz n de Prevalencia [RP] = 17,70; Intervalo de Confianza [IC] ...
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Glucoprivation activates neurons in the perifornical hypothalamus (PeH) and in the rostral ventrolateral medulla (RVLM), which results in release of adrenaline. The current study aimed to establish (i) whether neuroglucoprivation in the PeH or in the RVLM elicits adrenaline release in vivo; and (ii) whether direct activation by glucoprivation or orexin release in the RVLM modulates the adrenaline release. Neuroglucoprivation in the PeH or RVLM was elicited by microinjections of 2-deoxy-D-glucose or 5-thio-D-glucose in anesthetized, euglycemic, rats. We found that inhibition of neurons in the PeH abolished the increase in adrenal sympathetic nerve activity (ASNA) to systemic glucoprivation. Secondly, glucoprivation of neurons in the PeH increased ASNA. Thirdly, in vivo or in vitro glucoprivation did not affect the activity of RVLM adrenal premotor neurons. Finally, blockade of orexin receptors in the RVLM abolished the increase in ASNA to neuroglucoprivation in the PeH. The evoked changes in ASNA ...
The arsR-type HTH domain is a DNA-binding, winged helix-turn-helix (wHTH) domain present in transcription regulators of the arsR/smtB family, involved in stress-response to heavy metal ions. This family of prokaryotic metal-sensing transcription repressors is named after Escherichia coli arsR, an arsenic-responsive repressor of the ars operon for arsenate reductase and metal ion extrusion, and after Synechococcus PCC 7942 smtB, a Zn(II)-responsive repressor of the smtA gene for a Zn sequestering metallothionein [ (PUBMED:12829264) ]. ArsR/smtB-like repressors of metal resistance operons specifically bind to the operator/promoter and seem to dissociate from the DNA in the presence of metal ions, permitting transcription of proteins involved in metal-ions efflux and/or detoxification. The crystal structure of the cyanobacterial smtB shows a fold of five alpha-helices (H) and a pair of antiparallel beta-strands (B) in the topology H1-H2-H3-H4-B1-B2-H5. Helices 3 and 4 comprise the helix-turn-helix ...
As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates to their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation (PubMed:20676083, PubMed:21636303, PubMed:21743475, PubMed:28104892). The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum (PubMed:20676083, PubMed:28104892). Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome (PubMed:28104892). Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the
Wiki-Pi: a web resource for human protein-protein interactions. It shows genes and PPIs with information about pathways, protein-protein interactions (PPIs), Gene Ontology (GO) annotations including cellular localization, molecular function and biological process, drugs, diseases, genome-wide association studies (GWAS), GO enrichments, PDB ID, Uniprot ID, HPRD ID, and word cloud from pubmed abstracts.
Villadangos, A. F., K. Van Belle, K. Wahni, V. Tamu Dufe, S. Freitas, H. Nur, S. De Galan, J. A. Gil, J-F. Collet, L. M. Mateos, et al., Corynebacterium glutamicum survives arsenic stress with arsenate reductases coupled to two distinct redox mechanisms., Mol Microbiol, vol. 82, issue 4, pp. 998-1014, 2011 Nov. ...
Villadangos, A. F., K. Van Belle, K. Wahni, V. Tamu Dufe, S. Freitas, H. Nur, S. De Galan, J. A. Gil, J-F. Collet, L. M. Mateos, et al., Corynebacterium glutamicum survives arsenic stress with arsenate reductases coupled to two distinct redox mechanisms., Mol Microbiol, vol. 82, issue 4, pp. 998-1014, 2011 Nov. ...
Gihring, Thomas M.; Bond, Philip L.; Peters, Stephen C.; Banfield, Jillian F. «Arsenic resistance in the archaeon Ferroplasma acidarmanus: new insights into the structure and evolution of the ars genes». Extremophiles. Springer-Verlag, 7, 2, 01-04-2003, pàg. 123-130. DOI: 10.1007/s00792-002-0303-6. ISSN: 1433-4909. ...
Undoped and Nickel chloride doped sodium fluoro antimonite (SFA) crystals were grown by slow evaporation technique at room temperature. The solu...
Friemel, Thomas N. (2008): Hierarchical Structures in Digraphs - Measurement and Interpretation. In: Serdült, Uwe/Täube, Volker G. (Eds.): Applications of Social Network Analysis ASNA 2005. Berlin: Wissenschaftlicher Verlag, p. 341-356. ISBN 978-3-86573-374-0 ...
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... arsenite-transporting ATPase * * No Wikipedia article EC 7.4.2.1: ABC-type polar-amino-acid transporter * EC 7.4.2.2: ABC-type ... mitochondrial protein-transporting ATPase * EC 7.4.2.4: chloroplast protein-transporting ATPase * EC 7.4.2.5: bacterial ABC- ... H+-transporting) * EC 7.1.1.4: caldariellaquinol oxidase (H+-transporting) * EC 7.1.1.5: menaquinol oxidase (H+-transporting ... Na+-transporting two-sector ATPase * EC 7.2.2.2: ABC-type Cd2+ transporter * EC 7.2.2.3: P-type Na+ transporter * EC 7.2.2.4: ...
Arsenic toxicity Arsenite-transporting ATPase Solute carrier family Active transport ATP-binding cassette transporter Hasgekar ... Arsenite-antimonite transporters are membrane transporters that pump arsenite or antimonite out of a cell. Antimonite is the ... an ATPase, must be superimposed onto ArsB. Arsenite and antimonite can also be pumped out of the cell by members of the ARC3 ... which can participate in both secondary transport or primary active transport. Based on operon analyses, Arc3 homologues may ...
... superfamily ARC3 family Arsenite-Antimonite efflux Arsenite-transporting ATPase Solute carrier family Active transport ATP- ... Arsenite or Antimonite (out). The overall reaction catalyzed by ArsB-ArsA is: Arsenite or Antimonite (in) + ATP ⇌ Arsenite or ... "Families of soft-metal-ion-transporting ATPases". Journal of Bacteriology. 181 (19): 5891-7. doi:10.1128/JB.181.19.5891- ... Arsenite resistance (Ars) efflux pumps of bacteria may consist of two proteins, ArsB (TC# 2.A.45.1.1; the integral membrane ...
In enzymology, an arsenite-transporting ATPase (EC 3.6.3.16) is an enzyme that catalyzes the chemical reaction ATP + H2O + ... and arsenite, whereas its 3 products are ADP, phosphate, and arsenite. This enzyme belongs to the family of hydrolases, ... Arsenite-Antimonite efflux Silver S, Misra TK, Laddaga RA (1989). "DNA sequence analysis of bacterial toxic heavy metal ... The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting). As of late 2007, 3 structures have been ...
V-type ATPase and A-type ATPase superfamily 3.A.3 The P-type ATPase Superfamily 3.A.4 The Arsenite-Antimonite efflux family 3.A ... Family 3.B.1 The Na+-transporting Carboxylic Acid Decarboxylase (NaT-DC) Family 3.C.1 The Na+ Transporting ... Family 1.D.58 The Anion Transporting Prodigiosene (Prodigiosene) Family 1.D.59 The Anion Transporting Perenosin (Perenosin) ... See electron transport chain. 3.D.1 The H+ or Na+-translocating NADH Dehydrogenase ("complex I") family 3.D.2 The Proton- ...
It is required for the detoxification of arsenate, arsenite, and antimonite. This system transports arsenite and antimonite out ... thus increasing its ATPase activity at lower concentrations of arsenite and enhancing the rate of arsenite extrusion. Carlin A ... This two-subunit enzyme produces resistance to arsenite and antimonite. Arsenate, however, must first be reduced to arsenite ... ArsA and ArsB form an anion-translocating ATPase. The ArsB protein is distinguished by its overall hydrophobic character, in ...
The Bacillus protein exports both arsenite and antimonite. The exact transport mechanism has not established. The generalized ... Homologous ATPases are found in families TC# 3.A.4, TC# 3.A.19 and TC# 3.A.21 as well as TC# 2.A.59. A region of the ABC ATPase ... In the latter case ATP hydrolysis again energizes transport. ARC3 homologues transport the same anions as ArsA/AB homologues, ... reaction catalyzed by members of the ACR3 family is: arsenite or antimonite (in) → arsenite or antimonite (out). Arsenite- ...
An underlying mechanism by which lead is able to cause harm is its ability to be transported by calcium ATPase pumps across the ... As a metabolite of arsenic, arsenite is formed after ingestion of arsenic and has shown significant toxicity to neurons within ... This is important as neurotransmitter transport can be impaired through vesicular transport inhibition, resulting in diminished ... This barrier creates a tight hydrophobic layer around the capillaries in the brain, inhibiting the transport of large or ...
Na+-transporting two-sector ATPase EC 3.6.3.16: Now EC 7.3.2.7, arsenite-transporting ATPase EC 3.6.3.17: Now covered by ... teichoic-acid-transporting ATPase EC 3.6.3.41: Now EC 7.6.2.5, heme-transporting ATPase EC 3.6.3.42: Now EC 7.5.2.3, β-glucan- ... fatty-acyl-CoA-transporting ATPase EC 3.6.3.48: Now EC 7.4.2.7 as α-factor-pheromone transporting ATPase EC 3.6.3.49: Now EC ... Na+/K+-exchanging ATPase EC 3.6.3.10: Now EC 7.2.2.19, H+/K+-exchanging ATPase EC 3.6.3.11: Cl--transporting ATPase. The ...
It has also been proposed that microtubules play a role in the formation of stress granules, perhaps by transporting granule ... Jain S, Wheeler JR, Walters RW, Agrawal A, Barsic A, Parker R (January 2016). "ATPase-Modulated Stress Granules Contain a ... June 2018). "ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules". ... In yeast, catalytic ded1 mutant alleles give rise to constitutive stress granules ATPase-deficient DDX3X (the mammalian homolog ...
Protons are transported across the membrane by the initial NADH reductase, quinones, and nitrous oxide reductase to produce the ... In all cases, however, a proton motive force is generated and used to drive ATP production via an ATPase. Most photosynthetic ... reduction to arsenite (AsO3− 3) Uranyl ion ion (UO2+ 2) reduction to uranium dioxide (UO 2) A number of organisms, instead of ... This means that these organisms do not use an electron transport chain to oxidize NADH to NAD+ and therefore must have an ...
... metal transporting P1-type ATPases and a chemiosmotic antiporter efflux system similar to CzcCBA of Cupriavidus metallidurans. ... MM-1 isolated from a soil and identification of arsenite oxidase gene". Journal of Hazardous Materials. 262: 997-1003. doi: ... Bahar, Md Mezbaul; Megharaj, Mallavarapu; Naidu, Ravi (2013-11-15). "Kinetics of arsenite oxidation by Variovorax sp. ...
arsenite-activated ATPase ArsA. 196. SEQF1709,CP001215.1. ACP12161.1 jb [NA] [AA] 696/231. 1389919-1390614. putative membrane ... bacitracin transport permease. 20. SEQF1709,CP001214.1. ACP11984.1 jb [NA] [AA] 393/130. 18659-18267. hypothetical protein. ...
gene product is an arsenite (antimonate)-stimulated ATPase. J. Biol. Chem. . 263. , 3067-3070 (1988). Search in Google Scholar ... gene encodes a putative membrane protein involved in arsenite transport. J. Biol. Chem. . 272. , 30061-30066 (1997). Search in ... Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces ... in rice enhanced arsenite efflux and reduced arsenic accumulation in rice grains. Plant Cell Physiol. . 53. , 154-163 (2012). ...
Kashyap DR, Botero LM, Franck WL, Hassett DJ, McDermott TR: Complex regulation of learn more arsenite oxidation by ... They include turgor and mechanical stress, ion or electrochemical gradients and transport processes. For find more instance, ... influence on ATPase activity and membrane fluidity. Mol Pharm ... of arsenic with detection and phylogenetic analysis of arsenite ... transport) and internal (cytoplasmatic solutes or proteins, redox state) conditions and integrate them. ...
ArseniteArsenite-induced Carcinogenesiscell cyclecirculting RNAExosomal circRNA_100284exosomeslivermalignant transformation ... AcidificationAtg5Autophagycancerendosomeexosomesextracellular vesiclesLC3multivesicular bodytumorV1V0-ATPase ... Fetal Membranes Contribute to Drug Transport across the Feto-Maternal Interface Utilizing the Breast Cancer Resistance Protein ... Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant ...
Vesicular Neurotransmitter Transport Proteins. *Cation Transport Proteins. *Arsenite Transporting ATPases. *Calcium- ... Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S. The alpha-1 subunit of the Na+,K+-ATPase ... "Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH ... An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ...
carboxylic acid-transporting ATPase activity GO:0033284 * L-ornithine transmembrane transporter activity ... arsenite secondary active transmembrane transporter activity GO:0008490 * succinate transmembrane transporter activity ...
ECA3 (ENDOPLASMIC RETICULUM-TYPE CALCIUM-TRANSPORTING ATPASE 3). Encodes a golgi localized P2A-type Ca2+ ATPase involved in Mn ... Also functions in arsenite transport and tolerance.. O.I.. C.G.. H.G.. Please select. TAIR (integral). KEGG (integral). ... F:binding;P:transport, mitochondrial transport;C:mitochondrial inner membrane, membrane;MFPO. O.I.. C.G.. H.G.. Please select. ... F:RNA binding, nucleotide binding, nucleic acid binding;P:transport, nucleocytoplasmic transport;C:intracellular;MFPOBV. O.I.. ...
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Aven-dependent activation of ATM following DNA damage. ... Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner ... Nuclear transport kinetics in microarrays of nuclear envelope patches. * PP1 control of M phase entry exerted through 14-3-3- ...
polar-amino acid-transporting ATPase activity GO:0015426 * L-arginine-importing ATPase activity ... ATPase-coupled arsenite transmembrane transporter activity GO:0015446 * L-glutamate transmembrane transporter activity ...
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Ascaris haemoglobin is a nitric oxide-activated 'deoxygenase ... MOP2 (SLA2) affects the abundance of the plasma membrane H(+)-ATPase of Saccharomyces cerevisiae. ... The U1 small nuclear ribonucleoprotein (snRNP) 70K protein is transported independently of U1 snRNP particles via a nuclear ... Molecular basis of defective anion transport in L cells expressing recombinant forms of CFTR. ...
ATPase, H+ transporting, lysosomal accessory protein 1. 0.011. Vdac1. voltage-dependent anion channel 1. 0.011. ... arsA arsenite transporter, ATP-binding, homolog 1 (bacterial). 0.077. arf2. ADP-ribosylation factor 2. 0.076. ... The network for 'er to golgi vesicle mediated transport' in your query organism is displayed on the left, if relationships are ... er to golgi vesicle mediated transport. The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, ...
Arsenite methyltransferase. Arsenite-transporting ATPase. Aryl sulfotransferase. Aryl-acylamidase. Aryl-alcohol dehydrogenase. ... Alpha-factor-transporting ATPase. Alpha-galactosidase. Alpha-glucan,water dikinase. Alpha-glucosidase. Alpha-glucosiduronase. ... Ag(+)-exporting ATPase. Agarase. Agaritine gamma-glutamyltransferase. Agmatinase. Agmatine N(4)-coumaroyltransferase. Agmatine ...
Many transport processes are energetically expensive and the cells use 20 to 60% of their energy to power the transportomes. We ... Davies JM, Hunt I, Sanders D. Vacuolar H(+)-pumping ATPase variable transport coupling ratio controlled by pH. Proc Natl Acad ... and the arsenite-antimonite efflux families, generally show a 1:2 stoichiometry of substrate:ATP hydrolysis [103,104,105,106, ... Families of soft-metal-ion-transporting ATPases. J Bacteriol. 1999;181:5891-7. ...
ATPases Associated with Diverse Cellular Activities [D08.811.277.040.025.024] * Arsenite Transporting ATPases [D08.811.277.040. ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ...
ATPase-coupled arsenite transmembrane transporter activity. IEP. Neighborhood. BP. GO:0015691. cadmium ion transport. IEP. ... xenobiotic transmembrane transporting ATPase activity. IEP. Neighborhood. MF. GO:0008641. ubiquitin-like modifier activating ... ATPase activity, coupled. IEP. Neighborhood. MF. GO:0042626. ATPase activity, coupled to transmembrane movement of substances. ... ATPase-coupled anion transmembrane transporter activity. IEP. Neighborhood. MF. GO:0043492. ATPase activity, coupled to ...
... "vacuolar ATPase V0 domain subunit c (17 kDa), endocytosis*, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... "Putative membrane protein involved in arsenite transport,arsenite transporter, " YJL206C-A 2.973031 INESSENTIAL YMR065W 2.97168 ... "vacuolar ATPase V1 domain subunit D, vacuolar acidification, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... hydrogen-transporting two-sector ATPase, hydrogen-transporting ATPase V0 domain" YHR021W-A 0.568915 INESSENTIAL ECM12 "( ...
In enzymology, an arsenite-transporting ATPase (EC 3.6.3.16) is an enzyme that catalyzes the chemical reaction ATP + H2O + ... and arsenite, whereas its 3 products are ADP, phosphate, and arsenite. This enzyme belongs to the family of hydrolases, ... Arsenite-Antimonite efflux Silver S, Misra TK, Laddaga RA (1989). "DNA sequence analysis of bacterial toxic heavy metal ... The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting). As of late 2007, 3 structures have been ...
gene product is an arsenite (antimonate)-stimulated ATPase. J. Biol. Chem. . 263. , 3067-3070 (1988). Search in Google Scholar ... gene encodes a putative membrane protein involved in arsenite transport. J. Biol. Chem. . 272. , 30061-30066 (1997). Search in ... Multiple cysteine residues are necessary for sorting and transport activity of the arsenite permease Acr3p from Saccharomyces ... in rice enhanced arsenite efflux and reduced arsenic accumulation in rice grains. Plant Cell Physiol. . 53. , 154-163 (2012). ...
arsenite-transporting ATPase. 7.3.2.7. ascorbate ferrireductase (transmembrane).. 7.2.1.3. autoinducer-2 transporter, ABC-type. ...
Arsenite methyltransferase. Arsenite-transporting ATPase. Aryl sulfotransferase. Aryl-acylamidase. Aryl-alcohol dehydrogenase. ... Alpha-factor-transporting ATPase. Alpha-galactosidase. Alpha-glucan,water dikinase. Alpha-glucosidase. Alpha-glucosiduronase. ... Ag(+)-exporting ATPase. Agarase. Agaritine gamma-glutamyltransferase. Agmatinase. Agmatine N(4)-coumaroyltransferase. Agmatine ...
ATPase-coupled arsenite transmembrane transporter activity. IEP. Neighborhood. BP. GO:0015691. cadmium ion transport. IEP. ... xenobiotic transmembrane transporting ATPase activity. IEP. Neighborhood. MF. GO:0008641. ubiquitin-like modifier activating ... ATPase activity, coupled. IEP. Neighborhood. MF. GO:0042626. ATPase activity, coupled to transmembrane movement of substances. ... ATPase-coupled anion transmembrane transporter activity. IEP. Neighborhood. MF. GO:0043492. ATPase activity, coupled to ...
arsenite transport. The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent ... ATPase-coupled arsenite transmembrane transporter activity. Enables the transfer of a solute or solutes from one side of a ... Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. Callose is a ... membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). ...
Vesicular Neurotransmitter Transport Proteins. *Cation Transport Proteins. *Arsenite Transporting ATPases. *Calcium- ... Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S. The alpha-1 subunit of the Na+,K+-ATPase ... "Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ...
ATPases Associated with Diverse Cellular Activities [D08.811.277.040.025.024] * Arsenite Transporting ATPases [D08.811.277.040. ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ... They consist of a conserved N-terminal region with weak ATPase activity, an endonuclease motif, and a C-terminal domain that ...
Arsenite Transporting ATPases. *Ca(2+) Mg(2+)-ATPase. *Calcium-Transporting ATPases. *Chaperonins ...
P-type ATPase (P-ATPase) Superfamily. Seventeen families of P-type ATPases are present under TC# 3.A.3. Thever, M.D. and M.H. ... The bile/arsenite/riboflavin transporter (BART) superfamily. FEBS Journal 274(3):612-29. Chen, J.S., V. Reddy, J.H. Chen, M.A. ... 2007). Mercury Transport in Bacteria. Water, Air, and Soil Pollution. 182: 219 - 234. Timothy Mok, JS. Chen, MA. Shlykov, MH. ... 2010). The p-type ATPase superfamily. J. Mol. Microbiol. Biotechnol. 19: 5-104.. 3.A.3 - The P-type ATPase (P-ATPase) ...
ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2. 0.024. TWF2. twinfilin, actin-binding protein, homolog 2 ( ... arsA arsenite transporter, ATP-binding, homolog 1 (bacterial). 0.024. SH3GL3. SH3-domain GRB2-like 3. 0.024. ...
Many transport processes are energetically expensive and the cells use 20 to 60% of their energy to power the transportomes. We ... Davies JM, Hunt I, Sanders D. Vacuolar H(+)-pumping ATPase variable transport coupling ratio controlled by pH. Proc Natl Acad ... and the arsenite-antimonite efflux families, generally show a 1:2 stoichiometry of substrate:ATP hydrolysis [103,104,105,106, ... Families of soft-metal-ion-transporting ATPases. J Bacteriol. 1999;181:5891-7. ...
Arsenite Transporting ATPases [D08.811.277.040.025.047] Arsenite Transporting ATPases * Ca(2+) Mg(2+) ATPase [D08.811.277.040. ... ATPases associated with diverse cellular activities Synonymes. AAA ATPases AAA+ ATPases ATPases AAA ATPases AAA+ ATPases ... AAA ATPases. AAA Proteases. AAA+ ATPases. AAA+ Proteases. ATPases AAA. ATPases AAA+. ATPases associées a diverses activités ... ATPases associated with diverse cellular activities Descripteur en anglais: ATPases Associated with Diverse Cellular Activities ...
... "vacuolar ATPase V0 domain subunit c (17 kDa), endocytosis*, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... "Putative membrane protein involved in arsenite transport,arsenite transporter, " YJL206C-A 2.973031 INESSENTIAL YMR065W 2.97168 ... "vacuolar ATPase V1 domain subunit D, vacuolar acidification, hydrogen-transporting two-sector ATPase, hydrogen-transporting ... hydrogen-transporting two-sector ATPase, hydrogen-transporting ATPase V0 domain" YHR021W-A 0.568915 INESSENTIAL ECM12 "( ...
An underlying mechanism by which lead is able to cause harm is its ability to be transported by calcium ATPase pumps across the ... known function of arsenite is its destructive nature towards the cytoskeleton through inhibition of neurofilament transport.[47 ... This is important as neurotransmitter transport can be impaired through vesicular transport inhibition, resulting in diminished ... This barrier creates a tight hydrophobic layer around the capillaries in the brain, inhibiting the transport of large or ...
polar-amino acid-transporting ATPase activity GO:0015426 * L-arginine-importing ATPase activity ... ATPase-coupled arsenite transmembrane transporter activity GO:0015446 * L-glutamate transmembrane transporter activity ...
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial). Molecular. skeletal muscle. Human. ASNA1. 4.0% Decrease Gene ... ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit. Molecular. skeletal muscle. Human. ATP5O. 2.0% Decrease ... AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast). Molecular. skeletal muscle. Human. AHSA2. 3.0% Increase ... ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9). Molecular. skeletal muscle. Human. ATP5G1. 4.0 ...
ECA3 (ENDOPLASMIC RETICULUM-TYPE CALCIUM-TRANSPORTING ATPASE 3). Encodes a golgi localized P2A-type Ca2+ ATPase involved in Mn ... Also functions in arsenite transport and tolerance.. O.I.. C.G.. H.G.. Please select. TAIR (integral). KEGG (integral). ... F:binding;P:transport, mitochondrial transport;C:mitochondrial inner membrane, membrane;MFPO. O.I.. C.G.. H.G.. Please select. ... F:RNA binding, nucleotide binding, nucleic acid binding;P:transport, nucleocytoplasmic transport;C:intracellular;MFPOBV. O.I.. ...
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Aven-dependent activation of ATM following DNA damage. ... Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner ... Nuclear transport kinetics in microarrays of nuclear envelope patches. * PP1 control of M phase entry exerted through 14-3-3- ...
Kashyap DR, Botero LM, Franck WL, Hassett DJ, McDermott TR: Complex regulation of learn more arsenite oxidation by ... They include turgor and mechanical stress, ion or electrochemical gradients and transport processes. For find more instance, ... influence on ATPase activity and membrane fluidity. Mol Pharm ... of arsenic with detection and phylogenetic analysis of arsenite ... transport) and internal (cytoplasmatic solutes or proteins, redox state) conditions and integrate them. ...
ATPase, H+ transporting, lysosomal accessory protein 1. 0.011. Vdac1. voltage-dependent anion channel 1. 0.011. ... arsA arsenite transporter, ATP-binding, homolog 1 (bacterial). 0.077. arf2. ADP-ribosylation factor 2. 0.076. ... The network for er to golgi vesicle mediated transport in your query organism is displayed on the left, if relationships are ... er to golgi vesicle mediated transport. The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, ...
arsenite-activated ATPase ArsA. 196. SEQF1709,CP001215.1. ACP12161.1 jb [NA] [AA] 696/231. 1389919-1390614. putative membrane ... bacitracin transport permease. 20. SEQF1709,CP001214.1. ACP11984.1 jb [NA] [AA] 393/130. 18659-18267. hypothetical protein. ...
ArseniteArsenite-induced Carcinogenesiscell cyclecirculting RNAExosomal circRNA_100284exosomeslivermalignant transformation ... AcidificationAtg5Autophagycancerendosomeexosomesextracellular vesiclesLC3multivesicular bodytumorV1V0-ATPase ... Fetal Membranes Contribute to Drug Transport across the Feto-Maternal Interface Utilizing the Breast Cancer Resistance Protein ... Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant ...
Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. * Ascites Increases Expression/Function of Multidrug ... The Golgi Calcium ATPase Pump Plays an Essential Role in Adeno-associated Virus Trafficking and Transduction. ... Biological Transport * Subject Areas on Research. * 22Na+ and 86Rb+ transport in vascular smooth muscle of SHR, Wistar Kyoto, ... Cerebral glucose transport and metabolism in preterm human infants. * Cerebral transport and metabolism of 1-11C-D-glucose ...
  • Lingemann M, McCarty T, Liu X, Buchholz UJ, Surman S, Martin SE, Collins PL, Munir S. The alpha-1 subunit of the Na+,K+-ATPase (ATP1A1) is required for macropinocytic entry of respiratory syncytial virus (RSV) in human respiratory epithelial cells. (uams.edu)
  • The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. (plant-scc.org)
  • In enzymology, an arsenite-transporting ATPase (EC 3.6.3.16) is an enzyme that catalyzes the chemical reaction ATP + H2O + arsenitein ⇌ {\displaystyle \rightleftharpoons } ADP + phosphate + arseniteout The 3 substrates of this enzyme are ATP, H2O, and arsenite, whereas its 3 products are ADP, phosphate, and arsenite. (wikipedia.org)
  • Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out). (plant-scc.org)
  • The APC superfamily consists of numerous families of porters that transport amino acids and their dereivatives. (tcdb.org)
  • Arsenite-Antimonite efflux Silver S, Misra TK, Laddaga RA (1989). (wikipedia.org)
  • In this article, we review recent advances in the understanding of arsenic toxicity and its transport routes in prokaryotes and eukaryotes, including a dual role of aquaglyceroporins in the uptake and efflux, active transport out of the cell via secondary ion pumps and sequestration of metalloid-thiol conjugates into vacuoles by primary ABC transporters. (sciendo.com)
  • The action of PINs in auxin efflux is distinct from PGPs, rate-limiting, specific to auxins and sensitive to auxin transport inhibitors. (or.jp)
  • S)-methylmalonyl-CoA decarboxylase (sodium-transporting). (holidayrecipestocook.com)
  • Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
  • An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. (uams.edu)
  • Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (uams.edu)
  • This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in UAMS Profiles by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications. (uams.edu)
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  • The systematic name of this enzyme class is ATP phosphohydrolase (arsenite-exporting). (wikipedia.org)
  • chloroplast protein-transporting ATPase. (holidayrecipestocook.com)
  • protein-secreting ATPase. (holidayrecipestocook.com)
  • These ATPase are found as coomponents of several protein secretion systems as well as synaptosomal fusion systems. (tcdb.org)
  • Phylogenetic characterization of transport protein superfamilies: superiority of SuperfamilyTree programs over those based on multiple alignments. (tcdb.org)
  • Larger structures are transported along microtubules to the cis-Golgi. (princeton.edu)
  • Additionally, the presence of substrate-binding proteins as the partners of a subset of membrane transporters [ 13 ] makes the cellular transport machinery more complicated than if we consider only the transporters themselves. (biomedcentral.com)
  • A large highly-conserved family of ATPases with diverse functions in cells that are characterized by the presence of a P-LOOP and a ring shape. (bvsalud.org)
  • This barrier creates a tight hydrophobic layer around the capillaries in the brain, inhibiting the transport of large or hydrophilic compounds. (wikipedia.org)
  • Many transport processes are energetically expensive and the cells use 20 to 60% of their energy to power the transportomes. (biomedcentral.com)
  • Thus, protective cells termed astrocytes surround the capillaries in the brain and absorb nutrients from the blood and subsequently transport them to the neurons, effectively isolating the brain from a number of potential chemical insults. (wikipedia.org)
  • Root-specific role in the transport of auxin. (or.jp)
  • Any process in which callose is transported to, and/or maintained in, the cell wall during the defense response. (plant-scc.org)
  • The APC superfamily consists of numerous families of porters that transport amino acids and their dereivatives. (tcdb.org)
  • The LysE Superfamily of Transport Proteins Involved in Cell Physiology and Pathogenesis. (tcdb.org)
  • also transports arsenite (As(III) and antimonite (Sb(III)) (Meng et al. (lbl.gov)
  • TauE14 is a pseudohyperphosphorylated mutant transporting 14 phosphomimetic (serine/threonine to glutamate) mutations22, which mimic hyperphosphorylation, a known driver of Tau misfolding and aggregation in AD and other tauopathies. (sc-scied.org)
  • The goal of the present study was to analyze the transport proteins in seven Bacteroides strains. (bestprobioticsforibs.com)
  • These seven strains were examined for analysis of the distributions of single and multicomponent transport systems and their substrates. (bestprobioticsforibs.com)
  • As example we present partial relations between a cluster of four genes of strain MG1363 (and their orthologs in query strains) and arsenite resistance (Figure 3B). (bcl-2inhibitors.com)
  • These genes were found to be relevant for check details strains growing at 0.9625 mM of arsenite and are present in most of the highly resistant strains. (bcl-2inhibitors.com)
  • Visualizing BIRB 796 occurrence of these genes in strains revealed that they are mostly absent in strains with no arsenite resistance phenotype and mostly present in strains with mild or high arsenite resistance phenotypes (Figure 3C). (bcl-2inhibitors.com)
  • Phylogeny as a Guide to Structure and Function of Membrane Transport Proteins. (tcdb.org)
  • The human genome encodes at least 1500 RNA binding proteins (RBPs) that regulate RNA metabolism from biogenesis to transport, localization and degradation, therefore playing a crucial role in cellular homeostasis1,2. (sc-scied.org)
  • Zafar H, Saier MH Jr (2018) Comparative genomics of transport proteins in seven Bacteroides species. (bestprobioticsforibs.com)
  • The research reported in the present communication is a continuation of a series of studies on the transport proteins in gut commensals and pathogens. (bestprobioticsforibs.com)
  • Thus, comprehending the mechanisms of water transport is essential to understanding mammalian kidney physiology and water balance. (abdominalkey.com)
  • However, these species have acquired alternative mechanisms to transport sugars into the cells and phosphorylate them [ 10 ]. (bestprobioticsforibs.com)
  • 2004). Oligomerization may play a role in determining the rate of transport. (lbl.gov)
  • download violence and warfare of Glutaredoxin1 and Glutathione in including the Role of the Copper-transporting P-type ATPases, ATP7A and ATP7B. (peacefulspiritmassage.com)
  • An interesting facet of the physiology of Bacteroides is the absence of transport-linked phosphorylation systems of the phosphotransferase system (PTS) [ 9 ]. (bestprobioticsforibs.com)
  • Purine nucleoside phosphorylase in the presence of dihydrolipoic acid is a route for reduction of arsenate to arsenite in mammalian systems. (nih.gov)
  • They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions. (nih.gov)
  • Sodium-Potassium-Exchanging ATPase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
  • This graph shows the total number of publications written about "Sodium-Potassium-Exchanging ATPase" by people in this website by year, and whether "Sodium-Potassium-Exchanging ATPase" was a major or minor topic of these publications. (uchicago.edu)
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  • An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. (uchicago.edu)
  • Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients. (uchicago.edu)
  • Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. (nih.gov)
  • We have previously shown that aquaglyceroporin channels, including Escherichia coli GlpF, Saccharomyces cerevisiae Fps1p, AQP7, and AQP9 from rat and human, conduct trivalent inorganic arsenic [As(III)] as arsenic trioxide, the protonated form of arsenite. (nih.gov)
  • that is, ATP is able to store and transport chemical energy within cells. (drugbank.com)
  • The arsenite production reaction of thymidine phosphorylase had approximately 5% of such PNP activity. (nih.gov)
  • Although the specific causal mechanism of doxorubicin-induced cardiotoxicity remains largely unclear, most of the evidence has indicated that doxorubicin is reduced to its semiquinone form by a mitochondria electron transport system. (biomedcentral.com)
  • For investigators to understand the mechanisms of arsenic toxicity and carcinogenesis as well as the ability of arsenic to serve as a chemotherapeutic agent, it is important to determine how methylated arsenicals are transported out of the liver and how they enter target tissues. (nih.gov)
  • Orlov SN, La J, Smolyaninova LV, Dulin NO. Na+,K+-ATPase as a Target for Treatment of Tissue Fibrosis. (uchicago.edu)