A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
Arsenite Transporting ATPases
A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)
Water Pollutants, Chemical
Nucleoside Transport Proteins
Trypanosoma brucei brucei
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Drug Resistance, Microbial
Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (1/1135)Primary blasts of a t(11;17)(q23;q21) acute promyelocytic leukaemia (APL) patient were analysed with respect to retinoic acid (RA) and arsenic trioxide (As2O3) sensitivity as well as PLZF/RARalpha status. Although RA induced partial monocytic differentiation ex vivo, but not in vivo, As203 failed to induce apoptosis in culture, contrasting with t(15;17) APL and arguing against the clinical use of As203 in t(11;17)(q23;q21) APL. Prior to cell culture, PLZF/RARalpha was found to exactly co-localize with PML onto PML nuclear bodies. However upon cell culture, it quickly shifted towards microspeckles, its localization found in transfection experiments. Arsenic trioxide, known to induce aggregation of PML nuclear bodies, left the microspeckled PLZF/RARalpha localization completely unaffected. RA treatment led to PLZF/RARalpha degradation. However, this complete PLZF/RARalpha degradation was not accompanied by differentiation or apoptosis, which could suggest a contribution of the reciprocal RARalpha/PLZF fusion product in leukaemogenesis or the existence of irreversible changes induced by the chimera. (+info)
NADPH oxidase inhibition does not interfere with low PO2 transduction in rat and rabbit CB chemoreceptor cells. (2/1135)The aim of the present work was to elucidate the role of NADPH oxidase in hypoxia sensing and transduction in the carotid body (CB) chemoreceptor cells. We have studied the effects of several inhibitors of NADPH oxidase on the normoxic and hypoxia-induced release of [3H]catecholamines (CA) in an in vitro preparation of intact CB of the rat and rabbit whose CA deposits have been labeled by prior incubation with the natural precursor [3H]tyrosine. It was found that diphenyleneiodonium (DPI; 0.2-25 microM), an inhibitor of NADPH oxidase, caused a dose-dependent release of [3H]CA from normoxic CB chemoreceptor cells. Contrary to hypoxia, DPI-evoked release was only partially Ca2+ dependent. Concentrations of DPI reported to produce full inhibition of NADPH oxidase in the rat CB did not prevent the hypoxic release response in the rat and rabbit CB chemoreceptor cells, as stimulation with hypoxia in the presence of DPI elicited a response equaling the sum of that produced by DPI and hypoxia applied separately. Neopterin (3-300 microM) and phenylarsine oxide (0.5-2 microM), other inhibitors of NADPH oxidase, did not promote release of [3H]CA in normoxic conditions or affect the response elicited by hypoxia. On the basis of effects of neopterin and phenylarsine oxide, it is concluded that NADPH oxidase does not appear to play a role in oxygen sensing or transduction in the rat and rabbit CB chemoreceptor cells in vitro and, in the context of the present study, that DPI effects are not related to NADPH oxidase inhibition. (+info)
Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. (3/1135)Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide (As2O3) has been demonstrated to be an effective drug in the treatment of acute promyelocytic leukemia by inducing programmed cell death in leukemic cells both in vitro and in vivo. This prompted us to study the in vitro effects of As2O3 and of another arsenical derivative, the organic compound melarsoprol, on human myeloma cells and on the plasma cell differentiation of normal B cells. At pharmacological concentrations (10(-8) to 10(-6) mol/L), As2O3 and melarsoprol caused a dose- and time-dependent inhibition of survival and growth in myeloma cell lines that was, in some, similar to that of acute promyelocytic leukemia cells. Both arsenical compounds induced plasma cell apoptosis, as assessed by 4',6-diamidino-2-phenylindole staining, detection of phosphatidylserine at the cell surface using annexin V, and by the terminal deoxynucleotidyl transferase-mediated nick end labeling assay. As2O3 and melarsoprol also inhibited viability and growth and induced apoptosis in plasma-cell enriched preparations from the bone marrow or blood of myeloma patients. In nonseparated bone marrow samples, both arsenical compounds triggered death in myeloma cells while sparing most myeloid cells, as demonstrated by double staining with annexin V and CD38 or CD15 antibodies. In primary myeloma cells as in cell lines, interleukin 6 did not prevent arsenic-induced cell death or growth inhibition, and no synergistic effect was observed with IFN-alpha. In contrast to As2O3, melarsoprol only slightly reduced the plasma cell differentiation of normal B cells induced by pokeweed mitogen. Both pokeweed mitogen-induced normal plasma cells and malignant plasma cells showed a normal nuclear distribution of PML protein, which was disrupted by As2O3 but not by melarsoprol, suggesting that the two arsenical derivatives acted by different mechanisms. These results point to the use of arsenical derivatives as investigational drugs in the treatment of multiple myeloma. (+info)
Interference in the quantitation of methylated arsenic species in human urine. (4/1135)The aim of this paper is to report on the presence of chemical interferences in the quantitation of methylated arsenic species in human urine when using a method based on selective volatile arsine species generation, chromatographic separation, and hydride generation atomic absorption spectrometry (HGAAS) detection. An abnormal profile of methylated arsenic species characterized by the absence of the peak corresponding to dimethylarsinic acid (DMA) was observed in urine from some individuals exposed to arsenic via drinking water and living in rural communities of northwestern Argentina. The absence of this peak persisted even after the addition of known amounts of DMA to the samples. However, the DMA peak appeared after urine digestion with hydrochloric acid (2M). Samples showing interferences were provided by individuals who had mate consumption and coca-leaf chewing habits. Because the relative proportions of methylated arsenic species present in urine have been used to evaluate the efficiency of the methylation process, interferences in the formation or detection of methylarsines may cause underestimation of As exposure and also lead to erroneous conclusions about relative biomethylation efficiencies. Therefore, we recommend that urine samples should be digested with 2M HCl before performing speciation analysis using HGAA techniques. Further studies on the impact of this type of interferences on other arsenic speciation methods are also required. (+info)
Phenylarsine oxide and ethanol prevent cell death of porcine polymorphonuclear leucocytes induced by phorbol myristate acetate. (5/1135)In this study, we report that phenylarsine oxide and ethanol, both of which suppress a number of polymorphonuclear leucocyte functions including superoxide production, prevented the phorbol myristate acetate-induced cell death in a dose-dependent manner. These reagents had an inhibitory effect even after polymorphonuclear leucocytes were stimulated to produce superoxide by treatment with phorbol myristate acetate. The results indicate that activation of protein kinase C and subsequent superoxide release do not directly cause phorbol myristate acetate-induced cell death. Phenylarsine oxide or ethanol prevents cell death by affecting pathways downstream from those involved in the superoxide production. (+info)
Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen. (6/1135)In this report we have studied the role of phosphatidylinositol 3'-kinase (PI3-K) and tyrosine phosphatase activation on platelet activation by Convulxin (Cvx). Wortmannin, a specific PI3-K inhibitor, and phenylarsine oxide (PAO), a sulfhydryl reagent that inhibits tyrosine phosphatase (PTPase), block Cvx-induced platelet aggregation, granule secretion, inositol phosphate production, and increase in [Ca2+]i. However, PAO does not inhibit Cvx-induced tyrosine phosphorylation of platelet proteins, including Syk and PLCgamma2, but blocked collagen-induced platelet aggregation as well as tyrosine phosphorylation of PLCgamma2. In contrast, Cvx-induced PLCgamma2 tyrosyl phosphorylation was partially inhibited by wortmannin. We conclude that (i) although Cvx and collagen activate platelets by a similar mechanism, different regulatory processes are specific to each agonist; (ii) mechanisms other than tyrosine phosphorylation regulate PLCgamma2 activity; and (iii) besides protein tyrosine kinases, PI3-K (and PTPase) positively modulate platelet activation by both Cvx and collagen, and this enzyme is required for effective transmission of GPVI-Fc receptor gamma chain signal to result in full activation and tyrosine phosphorylation of PLCgamma2 in Cvx-stimulated platelets. (+info)
Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (7/1135)BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically achievable concentrations. METHODS: Eight malignant lymphocytic cell lines and primary cultures of lymphocytic leukemia and lymphoma cells were treated with As2O3, with or without dithiothreitol (DTT) or buthionine sulfoximine (BSO) (an inhibitor of glutathione synthesis). Apoptosis was assessed by cell morphology, flow cytometry, annexin V protein level, and terminal deoxynucleotidyl transferase labeling of DNA fragments. Cellular proliferation was determined by 5-bromo-2'-deoxyuridine incorporation into DNA and flow cytometry and by use of a mitotic arrest assay. Mitochondrial transmembrane potential (delta psi(m)) was measured by means of rhodamine 123 staining and flow cytometry. Protein expression was assessed by western blot analysis or immunofluorescence. RESULTS: Therapeutic concentrations of As2O3 (1-2 microM) had dual effects on malignant lymphocytes: 1) inhibition of growth through adenosine triphosphate (ATP) depletion and prolongation of cell cycle time and 2) induction of apoptosis. As2O3-induced apoptosis was preceded by delta psi(m) collapse. DTT antagonized and BSO enhanced As2O3-induced ATP depletion, delta psi(m) collapse, and apoptosis. Caspase-3 activation, usually resulting from delta psi(m) collapse, was not always associated with As2O3-induced apoptosis. As2O3 induced PML (promyelocytic leukemia) protein degradation but did not modulate expression of cell cycle-related proteins, including c-myc, retinoblastoma protein, cyclin-dependent kinase 4, cyclin D1, and p53, or expression of differentiation-related antigens. CONCLUSIONS: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 microM As2O3. As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders. (+info)
Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. (8/1135)Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury. In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited. H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2. Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2. Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation. Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3. Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus. These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway. (+info)
Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells<...
TY - JOUR. T1 - Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. AU - Dodmane, Puttappa R.. AU - Arnold, Lora L. AU - Pennington, Karen L.. AU - Singh, Rakesh K. AU - Cardoso, Ana Paula Ferragut. AU - Cohen, Samuel Monroe. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Chronic exposure to high levels of inorganic arsenic (iAs) has been associated with cancerous and non-cancerous health effects, including cardiovascular effects. However, the mechanism for a presumed toxic effect of arsenic on vascular tissue is not clear. Our working hypothesis is that inorganic trivalent arsenic and its methylated metabolites react with cysteine-containing cellular proteins and alter their function leading to adverse events such as cytotoxicity or proliferation. In this study, human microvascular endothelial cells (HMEC1) and mouse microvascular endothelial cells (MFP-MVEC) were exposed to arsenite (iAsIII), monomethylarsonous acid (MMAIII), or dimethylarsinous acid ...
Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as...
Stock Photo 4128R-18191: Download Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as spheres and are colour_coded: arsenic violet and oxygen red. Stock Photos. Search over 12 million royalty free images and rights managed stock photography
Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells | Molecular Cancer | Full Text
During the last decade, ATO has been used effectively to treat both newly diagnosed and relapsed APL patients, with patients showing complete remission after low dose ATO treatment . The anti-cancer ability of ATO is not limited to APL  and many other tumors in animal models have been shown to be sensitive to ATO treatment [37, 38]. However, the lack of information on sites of action for ATO cytotoxicity in tumor types other than APL has limited its uptake for the treatment of other cancers until recent years .. In this study, we have demonstrated that complex IV of the ETC is a target for ATO. From a panel of ETC inhibitors, the decrease in ROS, decrease in ATP production and MMP depolarisation caused by low dose ATO treatment of T-47D cells was reproduced only by cyanide, a well characterised complex IV inhibitor (Figure 5). Direct measurement of cytochrome C oxidase activity in whole cells treated with ATO confirmed the ability of ATO to inhibit this enzyme activity directly. The ...
Phenylarsine oxide - Substance Information - ECHA
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond.
Citation: Ritchie, A.W., Edmonds, J.S., Goessler, W. and Jenkins, R.O. (2004) An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond. FEMS Microbiology Letters. 235 (1) pp.95-99 ...
15. DPDK Release 18.05 - Data Plane Development Kit 21.11.0-rc0 documentation
librte_acl.so.2 librte_bbdev.so.1 librte_bitratestats.so.2 + librte_bpf.so.1 librte_bus_dpaa.so.1 librte_bus_fslmc.so.1 librte_bus_pci.so.1 librte_bus_vdev.so.1 librte_cfgfile.so.2 librte_cmdline.so.2 + librte_common_octeontx.so.1 + librte_compressdev.so.1 librte_cryptodev.so.4 librte_distributor.so.1 + librte_eal.so.7 + librte_ethdev.so.9 + librte_eventdev.so.4 librte_flow_classify.so.1 librte_gro.so.1 librte_gso.so.1 librte_hash.so.2 librte_ip_frag.so.1 librte_jobstats.so.1 librte_kni.so.2 librte_kvargs.so.1 librte_latencystats.so.1 librte_lpm.so.2 + librte_mbuf.so.4 + librte_mempool.so.4 + librte_meter.so.2 librte_metrics.so.1 librte_net.so.1 librte_pci.so.1 librte_pdump.so.2 librte_pipeline.so.3 librte_pmd_bnxt.so.2 librte_pmd_bond.so.2 librte_pmd_i40e.so.2 librte_pmd_ixgbe.so.2 + librte_pmd_dpaa2_cmdif.so.1 + librte_pmd_dpaa2_qdma.so.1 librte_pmd_ring.so.2 librte_pmd_softnic.so.1 librte_pmd_vhost.so.2 librte_port.so.3 librte_power.so.1 librte_rawdev.so.1 librte_reorder.so.1 + ...
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Masuda Tomoyuki | TRIOS
Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines<...
TY - JOUR. T1 - Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. AU - Nakagawa, Yoshihito. AU - Akao, Yukihiro. AU - Morikawa, Hiroshi. AU - Hirata, Ichiro. AU - Katsu, Kenichi. AU - Naoe, Tomoki. AU - Ohishi, Nobuko. AU - Yagi, Kunio. N1 - Funding Information: The DLD-1 and COLO201 colon cancer cell lines used in this study were kindly supplied by the Health Science Research Resources Bank of the Japan Health Sciences Foundation. This work was supported in part by a Grant-in-Aid for Scientific Research by the Ministry of Education, Science, Sports and Culture of Japan.. PY - 2002/3/29. Y1 - 2002/3/29. N2 - Exposure of three colon cancer cell lines, SW480, DLD-1, and COLO201, to arsenic trioxide in the medium induced a marked concentration-dependent suppression of cell growth. The intracellular contents of reduced glutathione (GSH) in these cell lines tended to be inversely correlated with the sensitivity of the cells to arsenic trioxide. Among the ...
Gallium Arsenide Market Overview, Scope And Chemical Research 2018 | Trade Calls
There are 15 Chapters to deeply display the Global Gallium Arsenide market.. Chapter 1, to describe Gallium Arsenide Introduction, product scope, market overview, market opportunities, market risk, market driving force;. Chapter 2, to analyze the top manufacturers of Gallium Arsenide, with sales, revenue, and price of Gallium Arsenide, in 2016 and 2018;. Chapter 3, to display the competitive situation among the top manufacturers, with sales, revenue and market share in 2016 and 2018;. Chapter 4, to show the Global market by regions, with sales, revenue and market share of Gallium Arsenide, for each region, from 2012 to 2018;. Chapter 5, 6, 7, 8 and 9, to analyze the key regions, with sales, revenue and market share by key countries in these regions;. Chapter 10 and 11, to show the market by type and application, with sales market share and growth rate by type, application, from 2012 to 2018;. Chapter 12, Gallium Arsenide market forecast, by regions, type and application, with sales and revenue, ...
Arsenic trioxide: Its use in the treatment of acute promyelocytic leukemia<...
TY - JOUR. T1 - Arsenic trioxide. T2 - Its use in the treatment of acute promyelocytic leukemia. AU - Sanz, Miguel A.. AU - Lo-Coco, Francesco. PY - 2006. Y1 - 2006. N2 - Acute promyelocytic leukemia (APL) represents approximately 10-15% of all adult cases of acute myeloid leukemia and is characterized by a unique genetic abnormality and frequent association with a severe hemorrhagic diathesis. An arsenic trioxide formulation for intravenous infusion has been developed and is currently licensed for the induction of remission and consolidation in adult patients with relapsed/refractory APL. Several studies have shown that arsenic trioxide is highly effective in the treatment of relapsed/refractory patients with APL, achieving remission rates of ,80%, high rates of molecular remission, and durable periods of disease-free survival. Furthermore, recent studies indicate that arsenic trioxide may also have a role in the treatment of newly diagnosed patients, either as a single agent or in combination ...
Arsenides Exporter, Manufacturer, Distributor, Supplier, Trading Company, Arsenides India
TRIVENI INTERCHEM PVT. LTD. - Exporter, Manufacturer, Distributor, Supplier, Trading Company of Arsenides Aluminium arsenide,Aluminium gallium arsenide,Aluminium indium arsenide,Arsenide,Boron arsenide,Cadmium arsenide,Gallium arsenide,Gallium arsenide phosphide,Gallium manganese arsenide, India
Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients With Acute Myeloid Leukemia - Tabular...
Cycle 1 cytarabine 10 mg/m^2 was administered subcutaneously (sc) twice daily (bid) on days 1-14. 0.25 mg/kg arsenic trioxide was administered intravenously (iv) on days 1-5 and days 8-12. Cycle 2 A second identical cycle of cytarabine and arsenic trioxide was given to patients with persistent disease. Patients who achieved complete remission (CR), complete remission with incomplete platelet count recovery (CRp), or partial remission (PR) after 1 or 2 cycles received a 14-day consolidation cycle of cytarabine and arsenic trioxide with the doses and schedule identical to the initial cycle. A recovery period of up to 4 weeks between the attainment of CR, CRp, or PR and the initiation of consolidation treatment was allowed. Patients who completed consolidation treatment started maintenance treatment of arsenic trioxide 0.25 mg/kg iv on days 1 and 4 and cytarabine 10 mg/m^2 sc bid on days 1 through 7 of a 28-day cycle ...
Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia
The purpose of this study is to determine whether NRX 195183 is effective in the treatment of relapsed or refractory Acute Promyelocytic Leukemia
Study of Arsenic Trioxide in Small Cell Lung Cancer - Full Text View - ClinicalTrials.gov
The purpose of this study is to study the effect of an anticancer drug, Arsenic Trioxide, in patients with small cell lung cancer who have failed at least one standard chemotherapy regimen as well as patients who are unable to tolerate the standard treatment for their cancer. The investigators seek to establish the safety of and efficacy of Arsenic Trioxide in this patient group. The study will include up to 36 participants with small cell lung cancer.. The investigators want to find out what effects, good or bad, that the study drug has on your cancer. This study will also look at specific biomarkers in your blood and in the tumor tissue which may help the investigators to determine if the levels of these biomarkers are related to tumor response to treatment.. Arsenic Trioxide, also known by the brand name, Trisenox, is a chemotherapy drug approved by the Food and Drug Administration (FDA) for the treatment of a specific type of blood cancer called Acute Promyelocytic Leukemia. It works in part ...
Arsenic Trioxide - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Arsenic Trioxide - Get up-to-date information on Arsenic Trioxide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Arsenic Trioxide
ARSENIC TRIOXIDE (ARSENITE)
Arsenic is a highly poisonous metallic element in the nitrogen family of group Va in the periodic table. Symbol As; aomic number 33; atomic mass 74.9216; melting point ca 817°C; sublimation point ca 613°C; specific gravity 6.80 or 7.004; 5.73; valence -3, 0, +3, or +5.; electronic config. [Ar]3d104s24p3. It appears in three allotropic forms, yellow, black, and gray. The stable form is a brittle, steel-gray hexagonal solid that oxidizes rapidly in air, and at high temperatures burns to form a white cloud of arsenic trioxide. Arsenic and some arsenic compounds sublime when heated and convert to gaseous form. Arsenic is an omnipresent element as arsenic minerals in the various lithosphere or fossil fuels including realgar, orpiment, and arsenopyrite. It is prepared commercially from arsenical pyrites (sulfide ores) by condensation of sublimed gas and by the reduction of white arsenic with carbon. This element contributes hardness and is used in preparing alloys for hard and corrosion-resistant ...
Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...
JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia
Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...
JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive...
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism. Benjamin D. Bowling, Nicole Doudican, Prashiela Manga, and Seth J. Orlow, Department of Dermatology, NYU School of Medicine, New York City, New York. (Sponsored by David J. Leffell, Department of Dermatology, Yale University School of Medicine). Current standard chemotherapeutic regimens for malignant melanoma are unsatisfactory. Although in vitro studies of arsenic trioxide (ATO) have demonstrated promise against melanoma, recent phase II clinical trials have failed to show any significant clinical benefit when used as a single agent. To enhance the efficacy of ATO in the treatment of melanoma, we sought to identify compounds that potentiate the cytotoxic effects of ATO in melanoma cells. Through a screen of 2000 marketed drugs and naturally occurring compounds, and subsequent mechanistic testing, a variety of antibiotic inhibitors of ...
arsenic trioxide Intravenous - patient information, description, dosage and directions.
Description of the drug arsenic trioxide Intravenous. - patient information, description, dosage and directions. What is arsenic trioxide Intravenous!
Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk...
Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk Acute Promyelocytic Leukemia (APL)
Trisenox (Arsenic Trioxide Injection): Side Effects, Interactions, Warning, Dosage & Uses
Learn about Trisenox (Arsenic Trioxide Injection) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
Evaluation of Arsenic Trioxide Potential for Lung Cancer Treatment: ASSessment of Apoptotic Mechanisms and Oxidative Damage -...
Abstract: Background: Lung cancer is one of the most lethal and common cancers in the world, causing up to 3 million deaths annually. The chemotherapeutic drugs that have been used in treating lung cancer include cisplatinpemetrexed, cisplastin-gencitabinoe, carboplatin-pacitaxel and crizotinib. Arsenic trioxide (ATO) has been used in the treatment of acute promyelocytic leukemia. However, its effects on lung cancer are not known. We hypothesize that ATO may also have a bioactivity against lung cancer, and its mechanisms of action may involve apoptosis, DNA damage and changes in stress-related proteins in lung cancer cells. Methods: To test the above stated hypothesis, lung carcinoma (A549) cells were used as the test model. The effects of ATO were examined by performing 6-diamidine-2 phenylindole (DAPI) nuclear staining for morphological characterization of apoptosis, flow cytometry analysis for early apoptosis, and western blot analysis for stressrelated proteins (Hsp70 and cfos) and apoptotic ...
Arsenic trioxide - An old drug re... preview & related info | Mendeley
(2010) A., S.D.. Blood Reviews. Over the last 17years, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (As2O3) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, the role of As2O3 in front-line therapy is under investigation. Recent ...
PRIME PubMed | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined...
PubMed journal article: Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. Download Prime PubMed App to iPhone, iPad, or Android
OBSERVATION OF DARK LINE DEGRADATION SITES IN ALUMINUM GALLIUM ARSENIDE GALLIUM ARSENIDE DH LASER MATERIAL BY ETCHING AND PHASE...
Arsenic trioxide in ovarian cancer | [email protected]
Arsenic trioxide (As2O3) has shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells were investigated. It was found that As2O3 treatment caused both apoptosis induction and caspase-independent cell death involving mitochondrial dysfunction. This was accompanied by endoplasmic reticulum stress induction and an increase in intracellular glutathione (GSH) level. The latter was in turn prevented by the concurrent use of GSH modulator, buthionine sulfoximine but not ascorbic acid. Gene expression analysis of arsenic-resistant OVCAR-3 (OVCAR-3/AsR) cells showed the involvement of multiple factors mediating its chemoresistance. Of particular interest, a genetic hub involving elevated interleukin 1A signalling was identified. This could consecutively modulate the ...
Arsenic trioxide in the mechanism of drug resistance reversal in MCF-7/ADM cell line of human breast cancer.
OBJECTIVE: To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human breast cancer cell line MCF-7/ADM. METHODS: Cytotoxicity of As(2)O(3) and the sensibility to adriamycin (ADM) in MCF-7/ADM cel
Figure 4 | Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung...
Figure 4: Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung Cancer
Clinical Trial | Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been...
Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been Removed By Surgery This study is currently…
Arsenic Trioxide - Manufacturer,Supplier,Exporter
AMBICA PHARMA - Manufacturer,Supplier,Exporter of Arsenic Trioxide from India. We offer best quality of products at a best price rate.
Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans:...
This epidemiological study investigated the association between β-cell function (a predictive factor of diabetes development) and the organic arsenic arsenobetaine (an agent less toxic to humans). Urine arsenobetaine was revealed to be associated with HOMA-β in the normal population (without diabetes), especially in males, even after adjusting for factors affecting diabetes and β-cell function, while no association was shown with HOMA-IR which is associated with insulin resistance.. Despite several conflicting results, arsenic has been reported to be correlated with diabetes in many epidemiological studies [6, 9, 23-31], and arsenic can affect insulin resistance and β-cell function . In some experimental studies, arsenite was found to induce oxidative stress in pancreatic β-cells and reduce insulin transcription and secretion [32, 33], caused by the altered expression of essential genes such as the Pdx1 gene [34, 35] and insulin gene  for pancreas development, insulin production, and ...
Effective treatment for rare leukemia
Adult patients who received the chemotherapy drug arsenic trioxide (Trisenox) immediately after standard chemotherapy had a significantly higher remission rate and better overall survival than those who received standard chemotherapy, according results of a phase III cancer clinical trial for an uncommon form of leukemia.. Seventy-seven percent of adult patients with acute promyelocytic leukemia who received arsenic trioxide remained alive and in remission, free of relapse, three years after diagnosis. This compared with 59 percent on the standard treatment. The greater effectiveness of the experimental combination also resulted in better overall survival of 86 percent after three years for the patients who received the arsenic trioxide compared to 77 percent for patients on the standard treatment arm.. Dr. Fred Appelbaum, director of the Centers Clinical Research Division, helped conceive, write the protocol, enroll patients and write up the results for the NCI-sponsored trial.. Acute ...
Steady-State and Transient Electron Transport within Bulk InAs, InP and GaAs: An Updated Semiclassical Three-Valley Monte Carlo...
An ensemble Monte Carlosimulation is used to compare high field electron transport in bulk InAs, InP and GaAs. In particular, velocity overshoot and electron transit times are examined. For all materials, we find that electron velocity overshoot only occurs when the electric field is increased to a value above a certain critical field, unique to each material. This critical field is strongly dependent on the material, about 3 kV/cm for InAs, 10 kV/cm for InP and 5 kV/cm for the case of GaAs, We find that InAs exhibits the highest peak overshoot velocity and that this velocity overshoot lasts over the longest distances when compared with GaAs and InP. Finally, we estimate the minimum transit time across a 1 μm InAs sample to be about 2 ps. Similar calculations for InP and GaAs yield 6.6 and 5.4 ps, respectively. We find that the optimal cutoff frequency for an ideal InAs based device ranges from around 79 GHz when the device thickness is set to 1 μm. We thus suggest that indium arsenide offers great
Radioprotection and Cell Cycle Arrest of Intestinal Epithelial Cells by Darinaparsin, a Tumor Radiosensitizer (Journal Article)...
Purpose: It was recently reported that the organic arsenic compound darinaparsin (DPS) is a cytotoxin and radiosensitizer of tumor cells in vitro and in subcutaneous xenograft tumors. Surprisingly, it was also found that DPS protects normal intestinal crypt epithelial cells (CECs) from clonogenic death after ionizing radiation (IR). Here we tested the DPS radiosensitizing effect in a clinically relevant model of prostate cancer and explored the radioprotective effect and mechanism of DPS on CECs. Methods and Materials: The radiation modification effect of DPS was tested in a mouse model of orthotopic xenograft prostate cancer and of IR-induced acute gastrointestinal syndrome. The effect of DPS on CEC DNA damage and DNA damage responses was determined by immunohistochemistry. Results: In the mouse model of IR-induced gastrointestinal syndrome, DPS treatment before IR accelerated recovery from body weight loss and increased animal survival. DPS decreased post-IR DNA damage and cell death, ...
Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for phase I clinical trial<...
TY - JOUR. T1 - Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for phase I clinical trial. AU - Elliott, Moira. AU - Ford, S J. AU - Prasad, E. AU - Dick, L J. AU - Farmer, H. AU - Hogg, P J. AU - Halbert, G W. N1 - Copyright © 2012 Elsevier B.V. All rights reserved.. PY - 2012/4/15. Y1 - 2012/4/15. N2 - The novel organoarsenical GSAO, 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid, has potential anti-angiogenic capability with application in cancer where tumour metastasis relies on neo-vascularisation. As GSAO arsenic is trivalent, the arsenoxide moiety reacts with appropriately spaced cysteine residues on adenine nucleotide translocase (ANT) mitochondrial membrane protein. Molecular oxidation of the arsenic to the pentavalent structure, as in the degradant GSAA (4-(N-(S-glutathionylacetyl)amino) phenylarsonic acid), prevents sulphydryl interaction and risks abolition of activity. We report here on formulation studies aiming to produce a parenteral ...
ATRA-arsenic new standard of care for APL - PM360
FROM JOURNAL OF CLINICAL ONCOLOGY. The combination of all-trans--retinoic acid (ATRA) and arsenic trioxide continues to show advantages over ATRA and chemotherapy as first-line therapy for patients with low- or intermediate-risk acute promyelocytic leukemia (APL), investigators report.. The final analysis of the APL046 study , a noninferiority trial of ATRA plus arsenic trioxide (ATRA-ATO) vs. ATRA and standard chemotherapy, showed that event-free survival (EFS) and overall survival (OS) were significantly better among patients assigned to ATRA-ATO. Patients in this group also had a significantly lower cumulative incidence of relapse, reported Francesco Lo-Coco, MD, of University Tor Vergata in Rome and colleagues.. Our results support the use of ATRA-ATO in patients with newly diagnosed APL and point to this strategy as the new standard of care for low- or intermediate-risk patients. Studies exploring the role of ATRA-ATO are warranted in other APL subsets including high-risk, pediatric, and ...
Background Lung tumor is among the most lethal and common malignancies - HDAC Inhibition for the Disruption of Latent HIV-1...
Background Lung tumor is among the most lethal and common malignancies in the world leading to up to 3 million fatalities annually. for morphological characterization of apoptosis movement cytometry evaluation for early apoptosis and traditional western blot evaluation for stress-related protein (Hsp70 and cfos) and apoptotic proteins expressions. Also the one cell gel electrophoresis (Comet) assay was utilized to judge the genotoxic impact. Outcomes ATO-induced apoptosis was evidenced by chromatin condensation and formation of apoptotic bodies as revealed by DAPI nuclear staining. Cell shrinkage and membrane blebbing were Neratinib observed at 4 and 6 μg/ml of ATO. Data from the western blot analysis revealed a significant dose-dependent increase (p < 0.05) in the Hsp 70 caspase 3 and p53 protein expression and a significant (p < 0.05) decrease in the cfos and bcl-2 protein expression at 4 and 6 μg/ml of ATO. There was a slight decrease in cytochrome c protein expression at 4 and 6 μg/ ml of ...
Legal Notice | TRISENOX® (arsenic trioxide) injection
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Arsenic Compounds Effective Against APL | Cancer Network | The Oncology Journal
NEW ORLEANS-Two forms of arsenic are effective for inducing remissions in people with acute promyelocytic leukemia (APL), according to data presented at the ASH meeting. 1
Organometallic vapor-phase homoepitaxy of gallium arsenide assisted by a downstream hydrogen
Hydrogen passivation of Si Î´-doped GaAs grown by molecular beam epitaxy. Swaminathan, V.; Asom, M. T.; Livescu, G.; Geva, M.; Stevie, F. A.; Pearton, S. J.; Lopata, J. // Applied Physics Letters;12/31/1990, Vol. 57 Issue 27, p2928 Hydrogen passivation of Si Î´-doped GaAs grown by molecular beam epitaxy is studied. Just as in uniformily Si-doped GaAs, exposure of the Î´-doped material to a low frequency (30 kHz) hydrogen plasma at 250 Â°C for 30 min deactivates the Si donors in the Î´ spikes. For samples with Si... ...
The action of phenylarsine oxide on insulin stimulation of glucose transport in rat adipocytes | Biochemical Society...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
Inorganic Arsenicals (Toxicity) - Toxicology - Merck Veterinary Manual
Learn about the veterinary topic of Inorganic Arsenicals (Toxicity). Find specific details on this topic and related topics from the Merck Vet Manual.
STRIPED GALLIUM ARSENIDE LASERS: MODE SIZE AND EFFICIENCY. - Nokia Bell Labs
Trisenox Side Effects in Detail - Drugs.com
Learn about the potential side effects of Trisenox (arsenic trioxide). Includes common and rare side effects information for consumers and healthcare professionals.
Arsenic Trioxide in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial
Arsenic trioxide - toxicity, ecological toxicity and regulatory information
Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.
Background The tumor associated antigen (TAA) gp100 was one of the | Nutlin-3 overcomes arsenic trioxide resistance and tumor...
Background The tumor associated antigen (TAA) gp100 was one of the first identified and has been used in clinical trials to treat melanoma patients. also collected as secondary endpoints. Patients that were HLA-A*2402 positive with stage IV melanoma were enrolled according to the criteria set by the protocol and immunized with a vaccine consisting of epitope peptide (VYFFLPDHL, gp100-in4) emulsified with incomplete Freunds adjuvant (IFA) for the total of 4 occasions with two week intervals. Prior to each vaccination, peripheral bloodstream mononuclear cells (PBMCs) had been separated in the blood and kept at -80C. The kept PBMCs had been thawed and analyzed for the regularity from the peptide particular T lymphocytes by IFN- ELISPOT and MHC-Dextramer assays. Outcomes No related undesirable events higher than quality I had been seen in the six sufferers signed up for this research. No clinical replies had been seen in the enrolled sufferers although vitiligo was noticed following the vaccination ...
Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth | Oncotarget
https://doi.org/10.18632/oncotarget.5836 Wenchao Zhou, Lin Cheng, Yu Shi, Susan Q. Ke, Zhi Huang, Xiaoguang Fang, Cheng-wei Chu, Qi Xie, Xiu-wu Bian, Jeremy N. Rich, Shideng Bao
Most recent papers with the keyword Journal of clinical oncology meta analysis | Read by QxMD
BACKGROUND: The studies have demonstrated that arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) takes effects in treatment of acute promyelocytic leukemia (APL) through different underlying mechanisms. This has established the molecular foundation of ATO plus ATRA therapy. Currently, ATO plus ATRA has also been widely used in clinical practice. OBJECTIVE: To assess the efficacy and safety of ATO in combination with ATRA for APL. SEARCH STRATEGY: The Cochrane Library (Issue 1, 2009), Cochrane Central Register of Controlled Trials (from 1970 to January 2009), MEDLINE (from 1978 to October 2008), EMBASE (from 1950 to March 2009), Chinese Biological Medical Literature Database (from 1978 to December 2008), CNKI (from 1994 to December 2008), China Medical Academic Conference Database (from 1994 to December 2008) were electronically searched ...
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Find quality suppliers and manufacturers of 1309-64-4(Diantimony trioxide) for price inquiry. where to buy 1309-64-4(Diantimony trioxide).Also offer free database of 1309-64-4(Diantimony trioxide) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Ecocentric | The Arsenic in Your Chicken
Despite the threat to human health and the environment, industrial poultry producers continue to use arsenical drugs to boost growth rates. A new study measured how much of this arsenic ends up in your meat.
Magic bullet (medicine)
Research on arsenical dye. Ehrlich joined the Institute of Experimental Therapy (Institut für experimentelle Therapie) at ... Here his research focused on testing arsenical dyes for killing microbes. Arsenic was an infamous poison, and his attempt was ...
"organic arsenicals". EPA. "Trace Elements in Soils and Plants, Third Edition". CRC Press. Archived from the original on 21 ... However, arsenicals such as melarsoprol are still used for the treatment of trypanosomiasis, since although these drugs have ... These organic arsenicals were in turn phased out by 2013 in all agricultural activities except cotton farming. The ... "Phosphorus Deoxidized Arsenical Copper" with an arsenic content of 0.3% has an increased corrosion stability in certain ...
Lead hydrogen arsenate
Inorganic Arsenicals; Intent to Cancel Registrations for Pesticide Products Registered for Non-Wood Preservative Use; ... Herrick, Glenn Washington (1910). "The Snow-white Linden Moth". Historic Arsenical Pesticide Research (PDF) (Report). US ... Lead arsenate was the most extensively used arsenical insecticide. Two principal formulations of lead arsenate were marketed: ...
Suchard, Jeffrey R. (March 2006). "CBRNE - Arsenicals, Arsine". EMedicine. Retrieved 2006-09-05. Marsh, James (1836). "Account ...
... the Arsenical Constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in Metabolism of Arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Ng, J. C. (2005). " ...
Toxicity of trivalent arsenicalsEdit. Enzymes and receptors that contain thiol or sulfhydryl functional groups are actively ... Toxicity of pentavalent arsenicalsEdit. Due to its similar structure and properties, pentavalent arsenic metabolites are ... Ebert, F; Weiss, A (2011). "Arsenicals affect base excision repair by several mechanisms". Mutat. Res. 715 (1-2): 32-41. doi: ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ...
... the arsenical constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in metabolism of arsenicals" (PDF). Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Högberg, A. G. ...
List of chemical warfare agents
Arsenicals. *Ethyldichloroarsine (ED). *Methyldichloroarsine (MD). *Phenyldichloroarsine (PD). *2- ...
Arsenical brass. Arsenic; frequently aluminum. Used for boiler fireboxes. Cartridge brass (C260). 70. 30. -. ≤ 0.07. Good ...
Lin, Lin S.; Thomas, D. J.; Cullen, W. R.; Wang, C.; Styblo, M.; Del Razo, L. M. (2001). "Arsenicals inhibit thioredoxin ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ... Kitchin, K.T; Wallace, K (2008). "Evidence against the nuclear in situ binding of arsenicals-Oxidative stress theory of arsenic ... Nesnow, S; Roop, B.C (2002). "DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species". ...
... is an arsenical. It causes antibody formation and delayed hypersensitivity when bound to aromatic amino ...
Arsenical bronze artefacts are present. Their settlements were of pit houses and they buried their dead in stone cists covered ...
Leeds City Museum
Chestofbooks.com webpage: Arsenical soap. Chrystal, Paul (2016). Leeds in 50 Buildings: 9. Leeds City Museum 1819 Park Row. ... as the Victorians will have preserved it with arsenical soap. For over a century it has sagged somewhat, as can be seen in the ...
Imperial Oil (Superfund site)
One, which reprocessed waste oil, may have discharged wastes to a nearby stream; another company produced arsenical pesticides ...
Antimoine arsenical dans le commerce. Metz, Antoine, September 1820. Second mémoire sur les alliages du potassium et sur ...
Monosodium methyl arsonate
"Organic Arsenical Products Task Force". National Library of Medicine. "Sodium Methanearsonate". HSDB Database. Specific ...
ISBN 0-8493-0474-1. Jolliffe, D. M. (1993). "The history of the use of arsenicals in man". Journal of the Royal Society of ...
Fitzgerald GM, Vollmer T (2006-06-19). "CBRNE - Vesicants, Organic Arsenicals: L, ED, MD, PD, HL". WebMD. Retrieved 2008-12-23 ...
... is an arsenical vesicant which can be mixed with mustard agents for use in chemical warfare. PD was ... Phenyldichloroarsine, also known by its wartime name phenyl Dick and its NATO abbreviation PD, is an organic arsenical vesicant ... Fitzgerald GM, Vollmer T (19 June 2006). "CBRNE - Vesicants, Organic Arsenicals: L, ED, MD, PD, HL". emedicine. WebMD. ... Phenyldichloroarsine is one of four organic arsenicals, the other three are lewisite (L), methyldichloroarsine (MD), and ...
Since at least 2000 BC, arsenic and inorganic arsenical compounds were both medicine and poison. In the 19th century, inorganic ... In the late 1940s, Salvarsan was replaced in most regions by penicillin, yet organic arsenicals remained in use for ... For poultry and swine, arsanilic acid was among four arsenical veterinary drugs, along with carbarsone, nitarsone, roxarsone, ... the first organic arsenical drug. In 1905, in Britain, H W Thomas and A Breinl reported successful treatment of trypanosomiasis ...
List of patent medicines
Fowler's solution: an arsenical compound sold in the 19th century for various ailments including treatment of leukemia. ... Jolliffe, D. M. (1993). "A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289 ...
"A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007. PMID ...
From 1905, inorganic arsenicals like Fowler's solution saw diminished use as attention turned to organic arsenicals, starting ... As arsenical compounds are notably toxic and carcinogenic-with side effects such as cirrhosis of the liver, idiopathic portal ... "A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007. PMID ...
Black Widows of Liverpool
An Arsenical Solution of Fly Papers.- Unexampled Cruelty". I (16). Te Aroha News. 19 April 1884. p. 5. Retrieved 7 May 2012. ...
Toroku arsenic disease
"Chronic arsenical poisoning due to environmental pollution. Seven cases among inhabitants near an abandoned mine." (1976). ...
Arsenical copper production was also taking place. The ore was mined from some polymetallic ore deposits in the same area. ... First, the ore was smelted, and then the second step of cupellation was used to separate arsenical copper and silver. Tepe ...
Common laborers only had arsenical copper objects. The precious metal objects then clearly demonstrate a hierarchy within the ... over two-thirds of which were objects of arsenical bronze, tumbaga (low-karat gold), silver and copper alloys, and high-karat ... The greatness of Middle Sican metallurgy was the large scale smelting and diverse use of arsenical copper, which was more ...
Orlando, FL: Academic Press, 1986, 347-372; Uthus E.O., Evidency for arsenical essentiality, Environ. Geochem. Health, 1992, 14 ...
in oxidized zones of arsenical ores containing zinc. The type locality is the Daniel Mine (St. Daniel Mine), Neustädtel, ...
Outbreaks can be treated with an arsenical spray. Mating Eggs Larvae feeding on Quercus texana Larva Pupa Tuskes, Paul M.; P. ...
Arsenical - Wikipedia
Arsenical copper - Wikipedia
Arsenical copper contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced ... Arsenical bronze Rollason, EC (1949). Metallurgy for Engineers (2nd ed.). London: Arnold. "Archived copy". Archived from the ... Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. ...
Points from Letters: Arsenicals for Asthma | The BMJ
Arsenical Keratosis: Background, Pathophysiology, Etiology
encoded search term (Arsenical Keratosis) and Arsenical Keratosis What to Read Next on Medscape. Related Conditions and ... arsenical keratosis in 7.1%, and skin cancers in 1.5%. Of the 428 people with skin cancer, 72% also presented with arsenical ... Arsenical keratosis is not a fatal disease, but it may persist indefinitely and can become bothersome over time because of pain ... Arsenical cancer of skin. Histologic study with special reference to Bowens disease. Cancer. 1968 Feb. 21(2):312-39. [Medline] ...
Aliphatic organic arsenicals - definition of aliphatic organic arsenicals by The Free Dictionary
aliphatic organic arsenicals synonyms, aliphatic organic arsenicals pronunciation, aliphatic organic arsenicals translation, ... English dictionary definition of aliphatic organic arsenicals. aliphatic straight chain of carbon atoms of a propane molecule ... redirected from aliphatic organic arsenicals). Also found in: Thesaurus, Medical, Encyclopedia. aliphatic. straight chain of ... Aliphatic organic arsenicals - definition of aliphatic organic arsenicals by The Free Dictionary https://www.thefreedictionary. ...
Arsenical silver - definition of Arsenical silver by The Free Dictionary
Arsenical silver synonyms, Arsenical silver pronunciation, Arsenical silver translation, English dictionary definition of ... Arsenical silver. an ore of silver containing arsenic. See also: Arsenical ... Arsenical silver - definition of Arsenical silver by The Free Dictionary https://www.thefreedictionary.com/Arsenical+silver ... a href=https://www.thefreedictionary.com/Arsenical+silver,Arsenical silver,/a,. *Facebook ...
Arsenical Keratosis Clinical Presentation: History, Physical Examination, Complications
encoded search term (Arsenical Keratosis) and Arsenical Keratosis What to Read Next on Medscape. Related Conditions and ... Another type of arsenical keratosis seen in most patients with arsenical cancers manifests as scaly erythematous or pigmented ... Arsenical Keratosis Clinical Presentation. Updated: Apr 02, 2018 * Author: Chih-Shan Jason Chen, MD, PhD; Chief Editor: Dirk M ... Arsenical keratoses are usually multiple and typically occur at sites of friction and trauma, especially on the palms and the ...
Monosodium Methanearsonate (MSMA), an Organic Arsenical | Ingredients Used in Pesticide Products | US EPA
Background - Organic Arsenical Pesticides. MSMA is an organic arsenical, a class of herbicides that also includes DSMA, CAMA, ... Monosodium Methanearsonate (MSMA), an Organic Arsenical. Monosodium methanearsonate (MSMA) is an organic arsenical pesticide ... Following application, organic arsenicals like MSMA convert over time to a more toxic form in soil (inorganic arsenic) and can ... The Organic Arsenicals; Amendments to Terminate Uses; Amendment to Existing Stocks Provisions - FR Notice, March 27, 2013 ...
Impact of Inorganic Arsenicals on Vegetative Growth of Two Pakistani Origins Sunflower Cultivars
Chemical Database: Arsenical pesticides (EnvironmentalChemistry.com)
This page contains information on the chemical Arsenical pesticides including: 10 synonyms/identifiers; U.S. Code of Federal ... Arsenical pesticide, liquid*Arsenical pesticide, liquid, poisonous*Arsenical pesticide, liquid, toxic*Arsenical pesticide, ... Arsenical pesticides*Arsenical pesticides, liquid, flammable, toxic, flash point less than 23 degrees C*Arsenical pesticides, ... Arsenical pesticides, solid, toxic*Arsenical pesticides, toxic. 49 CFR 172.101 - Hazardous Materials Table. Hazardous materials ...
ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS | Science Inventory | US EPA
ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS. Contact. National Health and Environmental Effects Research ... ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED TRIVALENT ARSENICALS. Z Drobna1, I Jaspers2, D J Thomas3 and M Styblo1. ... Western blot analyses of the MAPK enzyme family in cells exposed to trivalent arsenicals showed a significant increase in p-ERK ... ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS. Presented at Society of Toxicology, Nashville, TN, March 17-21, ...
Case of Acute Arsenical Poisoning from the Use of Green Paint | The BMJ
Inorganic Arsenicals (Toxicity) - Toxicology - Merck Veterinary Manual
Learn about the veterinary topic of Inorganic Arsenicals (Toxicity). Find specific details on this topic and related topics ... Trivalent arsenicals, or arsenites, are more soluble and therefore more toxic than the pentavalent, or arsenate, compounds. ... The mechanism of action of arsenic toxicosis varies with the type of arsenical compound. Generally, tissues rich in oxidative ...
Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells | Environmental XPRT
Article Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells. Clark 1 (diphenylarsine chloride) and ... Please sign in or create your free account to view the content of Accumulation and toxicity of monophenyl arsenicals in rat ... Accumulation and toxicity of monophenyl arsenicals in rat ... You have requested access to an area of the website which ...
RCSB PDB - 1Y0U: Crystal Structure of the putative arsenical resistance operon repressor from Archaeoglobus fulgidus
arsenical resistance operon repressor, putative. A, B. 96. Archaeoglobus fulgidus DSM 4304. Mutation(s): 3 Gene Names: AF_0168 ... Crystal Structure of the putative arsenical resistance operon repressor from Archaeoglobus fulgidus. Kim, Y., Joachimiak, A., ... Crystal Structure of the putative arsenical resistance operon repressor from Archaeoglobus fulgidus. *DOI: 10.2210/pdb1Y0U/pdb ...
arsB - Arsenical-resistance protein - Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) - arsB gene & protein
Arsenical-resistance proteinImported. ,p>Information which has been imported from another database using automatic procedures ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... tr,B0TB51,B0TB51_HELMI Arsenical-resistance protein OS=Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) OX=498761 GN= ...
Mandibular Bone and Soft Tissues Necrosis Caused by an Arsenical Endodontic Preparation Treated with Piezoelectric Device
The arsD gene encodes a second trans-acting regulatory protein of the plasmid-encoded arsenical resistance operon. - PubMed -...
Fjoh 2991 - Arsenical-resistance protein - Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) - Fjoh 2991 gene &...
Arsenical-resistance proteinImported. ,p>Information which has been imported from another database using automatic procedures ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... tr,A5FFK0,A5FFK0_FLAJ1 Arsenical-resistance protein OS=Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) OX= ...
Arsenic toxicity (Arsenicism, Arsenicosis, Arsenical Keratoses, Arsenical pigmentation, Mees' lines - Clinical Advisor
Arsenic toxicity (Arsenicism, Arsenicosis, Arsenical Keratoses, Arsenical pigmentation, Mees lines Kathleen Rossy ... There is no pit formation with arsenical keratoses. Verruca vulgaris. Arsenical keratoses differ because the large number of ... Close more info about Arsenic toxicity (Arsenicism, Arsenicosis, Arsenical Keratoses, Arsenical pigmentation, Mees lines ... Close more info about Arsenic toxicity (Arsenicism, Arsenicosis, Arsenical Keratoses, Arsenical pigmentation, Mees lines ...
... have increased uptake of methylated arsenicals, which leads to increased cytotoxicity, as compared with inorganic arsenicals. ... The Novel Arsenical Darinaparsin Is Transported by Cystine Importing Systems. Nicolas Garnier, Geneviève G. J. Redstone, ... The Novel Arsenical Darinaparsin Is Transported by Cystine Importing Systems Message Subject (Your Name) has forwarded a page ... Here, we propose this route of cell entry may also exist for arsenicals and is likely to be specific to cysteine-S-conjugated ...
Effects of arsenicals on the DMI-induced reduction of C | Open-i
Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A) ... f5: Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A ... f5: Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A ... Cells were treated 1 day after confluence with DMI in the absence (control) or presence of arsenicals. Vehicle, growth medium ...
Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei | Eukaryotic Cell
Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei. Enock Matovu, Mhairi L. Stewart, Federico ... Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei. Enock Matovu, Mhairi L. Stewart, Federico ... Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei. Enock Matovu, Mhairi L. Stewart, Federico ... Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei Message Subject (Your Name) has forwarded a ...
Trivalent arsenicals are bound to proteins during reductive methylation. - Semantic Scholar
... and pentavalent arsenicals (MMA(V) and DMA(V)) were present as end products of metabolism, rather than intermediates. We also ... but not pentavalent arsenicals were bound to proteins in vitro, it was deduced that arsenic metabolites bound to proteins ... The relative ratios of the three arsenicals changed depending on organ, fraction (HMW and SED), and time. Since the arsenic ... Raman spectra of thiolated arsenicals with biological importance.. *Mingwei Yang, Yuzhen Sun, +4 authors Yong Cai ...
FDA Can't Keep a Secret-Agency Accidently Reveals Arsenical Drug Sales | Center for a Livable Future
In this case, 2010 sales of arsenicals would be even higher, as the reduction in arsenical sales needed to achieve a net ... of arsenicals were sold for use in food animals in 2010, the most recent year for which we can determine arsenical sales. ... In that event, more than 700,000 kg of arsenicals may once again be sold for use in producing our food, with a known carcinogen ... In other words, drug companies sold at least 706,530 kg of arsenicals in 2010; the actual quantity could be higher, but we ...
A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells ...
Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump | Biochemical Journal
Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump. Adrian R. WALMSLEY, Tongqing ... The ArsA ATPase is the catalytic subunit of the pump protein, coupling the hydrolysis of ATP to the movement of arsenicals and ... Abbreviations used: ArsAB, Escherichia coli arsenical pump; Sb(III), antimonite (i.e. potassium antimonyl tartrate); ABC, ATP- ... Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump ...
Welcome to CDC stacks | Silver-Catalyzed Oxidative Leaching of an Arsenical Copper Sulfide Concentrate; Bureau of Mines Report...
"A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by ... The Bureau of Mines investigated a silver-catalyzed oxidative procedure for leaching an arsenical copper sulfide concentrate ... Silver-Catalyzed Oxidative Leaching of an Arsenical Copper Sulfide Concentrate; Bureau of Mines Report of Investigations -1987 ... Calcium chloride-oxygen leaching and metals recovery from an arsenical copper-cobalt concentrate ...
Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial, International...
"Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial, International ... Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial. Elliott, M.A.; Ford ... Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I... Elliott, M.A.; Ford, S.J.; ... A peptide trivalent arsenical inhibits tumour angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells ...
Arsenicals | Semantic Scholar
Arsenicals. Known as: Arsenic Compounds, Arsenic Compound, arsenical Expand. A white, odorless, inorganic substance that ... Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). According to the postulated… Expand ... Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells ... The reactivities of methyloxoarsine (MAs(III)) and iododimethylarsine (DMAs(III)), two methylated trivalent arsenicals, toward ...
ToxicityCompoundsKeratosisKeratosesPesticideOrganic arsenical herbicidesCompoundTrivalent and pentavalentPentavalentInorganic arsenicToxicExposureHerbicidesResistanceMelarsoprolReplaced by organicDyesEscherichiaMechanismsAntibioticsSubstancesTrypanosomiasisCarcinomaCopperContaminationArsBRefractoryMethylationChemicalSoilChronicPoultryPathwayProteinAgriculturalMAPK
- Please sign in or create your free account to view the content of Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells . (environmental-expert.com)
- The identification of biotransformation products and their preliminary toxicity testing will also provide insight on the public health risks associated with the use of organo-arsenicals in agriculture. (usgs.gov)
- Arsenicals - toxicity 3. (inchem.org)
- Arsenical compounds are used in industrial, agricultural, and medicinal substances. (medscape.com)
- Arsenicals are chemical compounds that contain arsenic. (wikipedia.org)
- In a military context, the term arsenical refer to toxic arsenic compounds that are used as chemical warfare agents. (wikipedia.org)
- Interpretation of the results, however, may be complicated by the presence of other arsenicals in the algae, including unknown compounds. (thefreedictionary.com)
- Unfortunately, not only are arsenicals poisonous, but many arsenic compounds ignite and explode spontaneously in dry air. (thefreedictionary.com)
- Overall, cytotoxicity of trivalent arsenicals to microvascular endothelial cells is similar to their cytotoxicity to epithelial cells, and that these compounds are not mitogenic. (elsevier.com)
- Melarsen oxide, one of the arsenical drugs often administered to people with African sleeping sickness, can lose effectiveness due to the presence of three compounds: adenine, adenosine and dipyridamole. (readabstracts.com)
- Wahlberg JE, Boman A. Contact sensitivity to arsenical compounds. (springer.com)
- Arsenical keratosis on the sole of a carpenter. (medscape.com)
- Another type of arsenical keratosis seen in most patients with arsenical cancers manifests as scaly erythematous or pigmented patches on unexposed body areas. (medscape.com)
- Arsenical keratosis occasionally evolves into carcinoma after a number of years. (medscape.com)
- This also presents with yellow, symmetric hyperkeratotic papules of the palms and soles, but differs from arsenical keratosis because when the papule is removed a pit is formed. (clinicaladvisor.com)
- Arsenical keratosis appears as diffuse thickening involving palms and soles, alone or in combination with nodules usually symmetrically distributed. (thefreedictionary.com)
- These features were consistent with arsenical keratosis with superimposed dermatophytosis. (thefreedictionary.com)
- Arsenic also causes pigment changes and (very frequently) hyperkeratotic lesions of the skin called arsenical keratoses. (medscape.com)
- Arsenical keratoses are the most characteristic skin feature of long-term arsenic exposure. (medscape.com)
- These in vitro findings may have revealed part of the pathogenesis of arsenical keratoses. (medscape.com)
- Arsenical keratoses are usually multiple and typically occur at sites of friction and trauma, especially on the palms and the soles. (medscape.com)
- Arsenical keratoses are multiple, symmetric, yellow hyperkeratotic papules that range from 0.2-1 cm in size. (clinicaladvisor.com)
- Arsenical keratoses have compact hyperkeratosis and acanthosis. (clinicaladvisor.com)
- There is no pit formation with arsenical keratoses. (clinicaladvisor.com)
- Arsenical keratoses differ because the large number of symmetric lesions, the lack of pinpoint bleeding with paring of lesions, and the other associated findings ( ie, cutaneous melanosis and nail changes). (clinicaladvisor.com)
- Key words Arsenic, arsenical keratoses, non-Hodgkin's lymphoma. (thefreedictionary.com)
- Arsenical keratoses and non-Hodgkin's lymphoma: arsenic-induced or coincidental conditions? (thefreedictionary.com)
- Monosodium methanearsonate (MSMA) is an organic arsenical pesticide currently registered for use in the United States. (epa.gov)
- Assessment of contamination from arsenical pesticide use on orchards in the Great Valley region, Virginia and West Virginia, USA. (thefreedictionary.com)
- Groundwater may also contain elevated concentrations of arsenic due to contamination from arsenical pesticide runoff. (cdc.gov)
Organic arsenical herbicides3
- It remains legal to purchase and use organic arsenical herbicides according to label directions and precautions. (epa.gov)
- When used according to the label, organic arsenical herbicides do not pose an imminent hazard. (epa.gov)
- Signs and lesions caused by organic arsenical herbicides resemble those of inorganic arsenical poisoning. (msdvetmanual.com)
Trivalent and pentavalent1
- The plasmid-encoded arsenical resistance (ars) operon produces resistance to trivalent and pentavalent salts of arsenic and antimony. (nih.gov)
- Only trivalent arsenicals (arsenic trioxide and sodium m-arsenite), but not pentavalent arsenicals (arsenic acid and p-arsenilic acid), induced significant cell injury. (elsevier.com)
- Following application, organic arsenicals like MSMA convert over time to a more toxic form in soil (inorganic arsenic) and can contaminate drinking water through soil runoff. (epa.gov)
- Inorganic arsenic is a known human carcinogen , and the use of arsenicals to produce food animals is known to increase concentrations of inorganic arsenic in parts of animals that people eat. (livablefutureblog.com)
- Effects of inorganic arsenic, methylated arsenicals, and arsenobetaine on atherosclerosis in the [apoE.sup. (thefreedictionary.com)
- Current chemical tests and Biosensors detect only inorganic arsenic and total organic arsenicals. (fiu.edu)
- UROtsa cells were shown to be malignantly transformed following low-level exposure to both arsenite [As(III)] and its more toxic metabolite, monomethylarsonous acid [MMA(III)] providing additional models for studying arsenical-induced carcinogenesis of the bladder. (arizona.edu)
- The nonpathogenic bacterial biosensor developed by FIU can discriminate between the organic and inorganic arsenicals which is vital since arsenic is a toxic metalloid listed by the U.S. Environmental Protection Agency's (EPA) superfund list as a first of Hazardous Chemicals. (fiu.edu)
- The highly soluble organic arsenicals can concentrate in pools in toxic quantities after a rain has washed them from recently treated plants. (msdvetmanual.com)
- Arsenicals are used as desiccants or defoliants on cotton, and residues of cotton harvest fed to cattle may contain toxic amounts of arsenic. (msdvetmanual.com)
- These transformed cell lines allow researchers the ability to investigate the process of urothelial tumorigenesis at multiple time points of arsenical exposure. (arizona.edu)
- UROtsa cells were exposed to As(III) and MMA(III) both acutely and chronically to begin investigations into signaling pathway alterations that can lead to carcinogenesis in the human bladder upon exposure to arsenicals. (arizona.edu)
- These data clearly present evidence supporting a role for ROS in both acute and chronic toxicities associated with low-level arsenical exposure, and gives evidence that ROS are important in cellular transformation following MMA(III) exposure. (arizona.edu)
- The endothelial cells treated with1nM to 1μM concentrations of the three trivalent arsenicals did not show increased cell proliferation at 24, 48 or 72h or increased rate of proliferation at 72h of exposure. (elsevier.com)
- MSMA is an organic arsenical, a class of herbicides that also includes DSMA, CAMA, cacodylic acid and its sodium salt. (epa.gov)
- The use of inorganic arsenicals as herbicides has been reduced greatly because of livestock losses, environmental persistence, and their carcinogenic potential. (msdvetmanual.com)
- The arsD gene encodes a second trans-acting regulatory protein of the plasmid-encoded arsenical resistance operon. (nih.gov)
- In addition in wild-type strains of Streptomyces phosphate sensitivity of antibiotic biosynthesis did not show strong correlation with resistance of growth to arsenicals. (microbiologyresearch.org)
- We have investigated the effects of the organic arsenical, melarsoprol (a drug used for treatment of trypanosomiasis), upon induction of apoptosis in cell lines representative of chronic B-cell lymphoproliferative disorders. (biomedsearch.com)
Replaced by organic1
- More recently, inorganic forms have been replaced by organic arsenicals , such as disodium methylarsenate and cacodylic acid. (thefreedictionary.com)
- Here his research focused on testing arsenical dyes for killing microbes. (wikipedia.org)
- Probing the structure of pyruvate dehydrogenase multienzyme complex from Escherichia coli with trivalent arsenicals (Unpublished doctoral thesis). (ucalgary.ca)
- Microbial processes and microorganisms responsible for key conversions will be studied to gain better insight on the mechanisms responsible for the biotransformation of organic arsenicals. (usgs.gov)
- Antimicrobials include antibiotics such as penicillin and tetracycline, as well as drugs like arsenicals, used against pathogens in the intestines. (livablefutureblog.com)
- It is critical to note that although the USDA Organic certification program explicitly prohibits the use of arsenic-based pharmaceuticals in animal production (USDA 2016b), the label "no antibiotics added" only restricts the use of antibiotics and does not specifically prohibit arsenical antimicrobials (USDA 2015). (thefreedictionary.com)
- Substances such as inorganic arsenicals (sodium arsenite, arsenic trioxide), organic arsenicals (methyl arsonate, methyl arsonic acid), sodium chlorate, ammonium sulfamate, borax, and many others were formerly used on a large scale. (msdvetmanual.com)
- Unctuous substances of the consistence of, prix du cialis 20mg en france, convalescents from infectious diseases patients with healing chest, do you need a prescription for cialis in uk, they would rather take the germs than the chlorine. (healthybaking.org)
- A-receptor loosened arsenicals, trypanosomiasis proceed. (otkrovenie.net)
- Arsenical squamous cell carcinoma occurs less frequently than Bowen disease, but it appears to be more aggressive than sun-induced squamous cell carcinoma. (medscape.com)
- Previous reports have shown a much higher incidence of fatal metastases among patients with arsenical squamous cell carcinoma. (medscape.com)
- Arsenical copper contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced tendency to scaling. (wikipedia.org)
- Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. (wikipedia.org)
- The Bureau of Mines investigated a silver-catalyzed oxidative procedure for leaching an arsenical copper sulfide concentrate containing 10 pct As and 32 pct Cu_ Currently, there are no environmentally safe means to treat arsenical copper concentrates in the United States. (cdc.gov)
- Arsenic contamination of ground water and prevalence of arsenical dermatosis in the Hetao plain area Inner Mongolia China. (thefreedictionary.com)
- The ArsA ATPase is the catalytic subunit of the pump protein, coupling the hydrolysis of ATP to the movement of arsenicals and antimonials through the membrane-spanning ArsB protein. (biochemj.org)
- Objective To investigate the efficacy and adverse reactions of arsenicals in the treatment of refractory or relapsed multiple myeloma . (bvsalud.org)
- Methods The data of 21 patients with refractory or relapsed multiple myeloma were retrospectively analyzed, including 10 patients with arsenicals (the arsenious acid group) and 11 cases treated with new regimens or treatments containing Bortezomib (the control group ). (bvsalud.org)
- Trivalent arsenicals are bound to proteins during reductive methylation. (semanticscholar.org)
- Lower levels of inorganic arsenicals are known to be chemical carcinogens. (medscape.com)
- Task 3 will evaluate the fate of the organic arsenicals in soil microcosms by monitoring the aqueous-extractable, soil-bound and volatile As-species. (usgs.gov)
- Chronic exposures to inorganic arsenicals (iAs) increase risks of various types of cancer in humans. (epa.gov)
- The use of arsenic-based drugs, known as "arsenicals," in poultry and pork production is one of the more disturbing practices of the food animal industry (and that is saying something). (livablefutureblog.com)
- Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). (semanticscholar.org)
- A) Effects of various arsenicals on the expression of CHOP10 protein in the early stage of adipogenesis. (nih.gov)
- In order to monitor and predict the fate of organic arsenicals in the environment, the major biotransformation products expected from the microbial conversion of these agricultural chemicals should be understood. (usgs.gov)
- The goal of this project is to identify major metabolites accumulating in the environment from the bioconversion of agricultural organic arsenicals (i.e. (usgs.gov)
- The information obtained in the project will provide the basis for detecting and predicting the fate of agricultural organic arsenicals in the environment. (usgs.gov)
- Western blot analyses of the MAPK enzyme family in cells exposed to trivalent arsenicals showed a significant increase in p-ERK but not in p-JNK or in p-p38 levels. (epa.gov)