Arsenicals: Inorganic or organic compounds that contain arsenic.Arsenic: A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)Arsenic Poisoning: Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)Cacodylic Acid: An arsenical that has been used as a dermatologic agent and as an herbicide.Arsenites: Inorganic salts or organic esters of arsenious acid.Melarsoprol: Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.Ion Pumps: A general class of integral membrane proteins that transport ions across a membrane against an electrochemical gradient.Arsenite Transporting ATPases: Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions.Antimony: A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.Arsenates: Inorganic or organic salts and esters of arsenic acid.Roxarsone: An arsenic derivative which has anticoccidial action and promotes growth in animals.Trypanocidal Agents: Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.Dimercaprol: An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.Diminazene: An effective trypanocidal agent.Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.Oxides: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.Aquaglyceroporins: A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.Bowen's Disease: A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)Sodium Compounds: Inorganic compounds that contain sodium as an integral part of the molecule.Water Pollutants, Chemical: Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.Drinking Water: Water that is intended to be ingested.Nucleoside Transport Proteins: Proteins involved in the transport of NUCLEOSIDES across cellular membranes.Methylation: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)R Factors: A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.Methyltransferases: A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.Trypanosoma brucei brucei: A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).Urothelium: The epithelial lining of the URINARY TRACT.Glutathione: A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.Crithidia fasciculata: A species of monogenetic, parasitic protozoa usually found in insects.Trypanosoma: A genus of flagellate protozoans found in the blood and lymph of vertebrates and invertebrates, both hosts being required to complete the life cycle.Skin DiseasesOrganometallic Compounds: A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)Spectrophotometry, Atomic: Spectrophotometric techniques by which the absorption or emmision spectra of radiation from atoms are produced and analyzed.Trypanosomiasis, African: A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.Sulfides: Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.Medicine, Traditional: Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.Sulfhydryl Compounds: Compounds containing the -SH radical.Operon: In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.Multienzyme Complexes: Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.Urinary Bladder: A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.Adenosine Triphosphatases: A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Rats, Inbred F344Escherichia coli: A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.Environmental Exposure: The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.Kinetics: The rate dynamics in chemical or physical systems.Drug Resistance, Microbial: The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).Disulfides: Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (1/1135)

Primary blasts of a t(11;17)(q23;q21) acute promyelocytic leukaemia (APL) patient were analysed with respect to retinoic acid (RA) and arsenic trioxide (As2O3) sensitivity as well as PLZF/RARalpha status. Although RA induced partial monocytic differentiation ex vivo, but not in vivo, As203 failed to induce apoptosis in culture, contrasting with t(15;17) APL and arguing against the clinical use of As203 in t(11;17)(q23;q21) APL. Prior to cell culture, PLZF/RARalpha was found to exactly co-localize with PML onto PML nuclear bodies. However upon cell culture, it quickly shifted towards microspeckles, its localization found in transfection experiments. Arsenic trioxide, known to induce aggregation of PML nuclear bodies, left the microspeckled PLZF/RARalpha localization completely unaffected. RA treatment led to PLZF/RARalpha degradation. However, this complete PLZF/RARalpha degradation was not accompanied by differentiation or apoptosis, which could suggest a contribution of the reciprocal RARalpha/PLZF fusion product in leukaemogenesis or the existence of irreversible changes induced by the chimera.  (+info)

NADPH oxidase inhibition does not interfere with low PO2 transduction in rat and rabbit CB chemoreceptor cells. (2/1135)

The aim of the present work was to elucidate the role of NADPH oxidase in hypoxia sensing and transduction in the carotid body (CB) chemoreceptor cells. We have studied the effects of several inhibitors of NADPH oxidase on the normoxic and hypoxia-induced release of [3H]catecholamines (CA) in an in vitro preparation of intact CB of the rat and rabbit whose CA deposits have been labeled by prior incubation with the natural precursor [3H]tyrosine. It was found that diphenyleneiodonium (DPI; 0.2-25 microM), an inhibitor of NADPH oxidase, caused a dose-dependent release of [3H]CA from normoxic CB chemoreceptor cells. Contrary to hypoxia, DPI-evoked release was only partially Ca2+ dependent. Concentrations of DPI reported to produce full inhibition of NADPH oxidase in the rat CB did not prevent the hypoxic release response in the rat and rabbit CB chemoreceptor cells, as stimulation with hypoxia in the presence of DPI elicited a response equaling the sum of that produced by DPI and hypoxia applied separately. Neopterin (3-300 microM) and phenylarsine oxide (0.5-2 microM), other inhibitors of NADPH oxidase, did not promote release of [3H]CA in normoxic conditions or affect the response elicited by hypoxia. On the basis of effects of neopterin and phenylarsine oxide, it is concluded that NADPH oxidase does not appear to play a role in oxygen sensing or transduction in the rat and rabbit CB chemoreceptor cells in vitro and, in the context of the present study, that DPI effects are not related to NADPH oxidase inhibition.  (+info)

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. (3/1135)

Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide (As2O3) has been demonstrated to be an effective drug in the treatment of acute promyelocytic leukemia by inducing programmed cell death in leukemic cells both in vitro and in vivo. This prompted us to study the in vitro effects of As2O3 and of another arsenical derivative, the organic compound melarsoprol, on human myeloma cells and on the plasma cell differentiation of normal B cells. At pharmacological concentrations (10(-8) to 10(-6) mol/L), As2O3 and melarsoprol caused a dose- and time-dependent inhibition of survival and growth in myeloma cell lines that was, in some, similar to that of acute promyelocytic leukemia cells. Both arsenical compounds induced plasma cell apoptosis, as assessed by 4',6-diamidino-2-phenylindole staining, detection of phosphatidylserine at the cell surface using annexin V, and by the terminal deoxynucleotidyl transferase-mediated nick end labeling assay. As2O3 and melarsoprol also inhibited viability and growth and induced apoptosis in plasma-cell enriched preparations from the bone marrow or blood of myeloma patients. In nonseparated bone marrow samples, both arsenical compounds triggered death in myeloma cells while sparing most myeloid cells, as demonstrated by double staining with annexin V and CD38 or CD15 antibodies. In primary myeloma cells as in cell lines, interleukin 6 did not prevent arsenic-induced cell death or growth inhibition, and no synergistic effect was observed with IFN-alpha. In contrast to As2O3, melarsoprol only slightly reduced the plasma cell differentiation of normal B cells induced by pokeweed mitogen. Both pokeweed mitogen-induced normal plasma cells and malignant plasma cells showed a normal nuclear distribution of PML protein, which was disrupted by As2O3 but not by melarsoprol, suggesting that the two arsenical derivatives acted by different mechanisms. These results point to the use of arsenical derivatives as investigational drugs in the treatment of multiple myeloma.  (+info)

Interference in the quantitation of methylated arsenic species in human urine. (4/1135)

The aim of this paper is to report on the presence of chemical interferences in the quantitation of methylated arsenic species in human urine when using a method based on selective volatile arsine species generation, chromatographic separation, and hydride generation atomic absorption spectrometry (HGAAS) detection. An abnormal profile of methylated arsenic species characterized by the absence of the peak corresponding to dimethylarsinic acid (DMA) was observed in urine from some individuals exposed to arsenic via drinking water and living in rural communities of northwestern Argentina. The absence of this peak persisted even after the addition of known amounts of DMA to the samples. However, the DMA peak appeared after urine digestion with hydrochloric acid (2M). Samples showing interferences were provided by individuals who had mate consumption and coca-leaf chewing habits. Because the relative proportions of methylated arsenic species present in urine have been used to evaluate the efficiency of the methylation process, interferences in the formation or detection of methylarsines may cause underestimation of As exposure and also lead to erroneous conclusions about relative biomethylation efficiencies. Therefore, we recommend that urine samples should be digested with 2M HCl before performing speciation analysis using HGAA techniques. Further studies on the impact of this type of interferences on other arsenic speciation methods are also required.  (+info)

Phenylarsine oxide and ethanol prevent cell death of porcine polymorphonuclear leucocytes induced by phorbol myristate acetate. (5/1135)

In this study, we report that phenylarsine oxide and ethanol, both of which suppress a number of polymorphonuclear leucocyte functions including superoxide production, prevented the phorbol myristate acetate-induced cell death in a dose-dependent manner. These reagents had an inhibitory effect even after polymorphonuclear leucocytes were stimulated to produce superoxide by treatment with phorbol myristate acetate. The results indicate that activation of protein kinase C and subsequent superoxide release do not directly cause phorbol myristate acetate-induced cell death. Phenylarsine oxide or ethanol prevents cell death by affecting pathways downstream from those involved in the superoxide production.  (+info)

Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen. (6/1135)

In this report we have studied the role of phosphatidylinositol 3'-kinase (PI3-K) and tyrosine phosphatase activation on platelet activation by Convulxin (Cvx). Wortmannin, a specific PI3-K inhibitor, and phenylarsine oxide (PAO), a sulfhydryl reagent that inhibits tyrosine phosphatase (PTPase), block Cvx-induced platelet aggregation, granule secretion, inositol phosphate production, and increase in [Ca2+]i. However, PAO does not inhibit Cvx-induced tyrosine phosphorylation of platelet proteins, including Syk and PLCgamma2, but blocked collagen-induced platelet aggregation as well as tyrosine phosphorylation of PLCgamma2. In contrast, Cvx-induced PLCgamma2 tyrosyl phosphorylation was partially inhibited by wortmannin. We conclude that (i) although Cvx and collagen activate platelets by a similar mechanism, different regulatory processes are specific to each agonist; (ii) mechanisms other than tyrosine phosphorylation regulate PLCgamma2 activity; and (iii) besides protein tyrosine kinases, PI3-K (and PTPase) positively modulate platelet activation by both Cvx and collagen, and this enzyme is required for effective transmission of GPVI-Fc receptor gamma chain signal to result in full activation and tyrosine phosphorylation of PLCgamma2 in Cvx-stimulated platelets.  (+info)

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (7/1135)

BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically achievable concentrations. METHODS: Eight malignant lymphocytic cell lines and primary cultures of lymphocytic leukemia and lymphoma cells were treated with As2O3, with or without dithiothreitol (DTT) or buthionine sulfoximine (BSO) (an inhibitor of glutathione synthesis). Apoptosis was assessed by cell morphology, flow cytometry, annexin V protein level, and terminal deoxynucleotidyl transferase labeling of DNA fragments. Cellular proliferation was determined by 5-bromo-2'-deoxyuridine incorporation into DNA and flow cytometry and by use of a mitotic arrest assay. Mitochondrial transmembrane potential (delta psi(m)) was measured by means of rhodamine 123 staining and flow cytometry. Protein expression was assessed by western blot analysis or immunofluorescence. RESULTS: Therapeutic concentrations of As2O3 (1-2 microM) had dual effects on malignant lymphocytes: 1) inhibition of growth through adenosine triphosphate (ATP) depletion and prolongation of cell cycle time and 2) induction of apoptosis. As2O3-induced apoptosis was preceded by delta psi(m) collapse. DTT antagonized and BSO enhanced As2O3-induced ATP depletion, delta psi(m) collapse, and apoptosis. Caspase-3 activation, usually resulting from delta psi(m) collapse, was not always associated with As2O3-induced apoptosis. As2O3 induced PML (promyelocytic leukemia) protein degradation but did not modulate expression of cell cycle-related proteins, including c-myc, retinoblastoma protein, cyclin-dependent kinase 4, cyclin D1, and p53, or expression of differentiation-related antigens. CONCLUSIONS: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 microM As2O3. As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders.  (+info)

Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. (8/1135)

Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury. In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited. H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2. Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2. Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation. Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3. Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus. These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway.  (+info)

*Arsenical copper

... contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced ... Arsenical bronze Rollason, EC (1949). Metallurgy for Engineers (2nd ed.). London: Arnold. "Archived copy". Archived from the ... Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. ...

*Arsenical keratosis

An arsenical keratosis is a growth of keratin on the skin caused by arsenic, which occurs naturally in the earth's crust and is ... Arsenical keratoses may persist indefinitely, and some may develop into invasive squamous cell carcinoma. Metastatic arsenic ... ISBN 0-7216-2921-0. Yerebakan O, Ermis O, Yilmaz E, Basaran E (February 2002). "Treatment of arsenical keratosis and Bowen's ... Topical 5-fluorouracil cream or 5% imiquimod cream may be useful in treating arsenical keratoses and Bowen's disease. Freedberg ...

*Arsenical bronze

... has seen little use in the modern period. It appears that the closest equivalent goes by the name of arsenical ... Arsenical copper Charles, J. A. (January 1967). "Early Arsenical Bronzes - A Metallurgical view". American Journal of ... saw the use of arsenical bronze. Indeed, it seems that arsenical bronze was the most common alloy in use in the Mediterranean ... to be traded and used to make arsenical bronze elsewhere by addition to molten copper. Artifacts made of arsenical bronze cover ...

*Arsine

Suchard, Jeffrey R. (March 2006). "CBRNE - Arsenicals, Arsine". EMedicine. Retrieved 2006-09-05. Marsh, James (1836). "Account ...

*Colin Raston

... the arsenical constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in metabolism of arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Högberg, A. G. S. ( ...

*Arsenobetaine

... the Arsenical Constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in Metabolism of Arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Ng, J. C. (2005). " ...

*Arsenic poisoning

ISBN 0-7817-2845-2. Gebel TW (March 2001). "Genotoxicity of arsenical compounds". International Journal of Hygiene and ... "Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes". ...

*Arsenic biochemistry

Lin, Lin S.; Thomas, D. J.; Cullen, W. R.; Wang, C.; Styblo, M.; Del Razo, L. M. (2001). "Arsenicals inhibit thioredoxin ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ... Kitchin, K.T; Wallace, K (2008). "Evidence against the nuclear in situ binding of arsenicals-Oxidative stress theory of arsenic ... Nesnow, S; Roop, B.C (2002). "DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species". ...

*P-Azobenzenearsonate

... is an arsenical. It causes antibody formation and delayed hypersensitivity when bound to aromatic amino ...

*Karasuk culture

Arsenical bronze artefacts are present. Their settlements were of pit houses and they buried their dead in stone cists covered ...

*Leeds City Museum

However the pelt may now be dangerous after all, in a sense, as the Victorians may have preserved it with arsenical soap. ... Chestofbooks.com webpage: Arsenical soap. Information received 10 March 2009 verbally from museum curator. 24dash.com: Sting in ...

*Imperial Oil (Superfund site)

One, which reprocessed waste oil, may have discharged wastes to a nearby stream; another company produced arsenical pesticides ...

*Monosodium methyl arsonate

"Organic Arsenical Products Task Force". National Library of Medicine. "Sodium Methanearsonate". HSDB Database. ...

*Potassium arsenite

ISBN 0-8493-0474-1. DM, J. (1993). "The History of the use of Arsenicals in Man". Journal of the Royal Society of Medicine. 86 ...

*Methyldichloroarsine

Organic Arsenicals: L, ED, MD, PD, HL". WebMD. Retrieved 2008-12-23. Ledgard, J. (2006). The Laboratory History of Chemical ...

*Arsanilic acid

CS1 maint: Uses authors parameter (link) Jolliffe DM (1993). "A history of the use of arsenicals in man". Journal of the Royal ... Since at least 2000 BC, arsenic and inorganic arsenical compounds were both medicine and poison. In the 19th century, inorganic ... In the late 1940s, Salvarsan was replaced in most regions by penicillin, yet organic arsenicals remained in use for ... For poultry and swine, arsanilic acid was among four arsenical veterinary drugs, along with carbarsone, nitarsone, roxarsone, ...

*Black Widows of Liverpool

An Arsenical Solution of Fly Papers.- Unexampled Cruelty". Volume I, Issue 16. Te Aroha News. 19 April 1884. p. 5. Retrieved 7 ...

*Arsenite

"A history of the use of arsenicals in man" (pdf). Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007 . PMID ...

*Fowler's solution

At 1905, inorganic arsenicals, like Fowler's solution, saw diminished use as attention turned to organic arsenicals, starting ... As arsenical compounds are notably toxic and carcinogenic-with side effects such as cirrhosis of the liver, idiopathic portal ... "A history of the use of arsenicals in man" (pdf). Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007 . PMID ...

*Toroku arsenic disease

"Chronic arsenical poisoning due to environmental pollution. Seven cases among inhabitants near an abandoned mine." (1976). ...

*Sican culture

Common laborers only had arsenical copper objects. The precious metal objects then clearly demonstrate a hierarchy within the ... over two-thirds of which were objects of arsenical bronze, tumbaga (low-karat gold), silver and copper alloys, and high-karat ... The greatness of Middle Sican metallurgy was the large scale smelting and diverse use of arsenical copper, which was more ...

*Mineral (nutrient)

Orlando, FL: Academic Press, 1986, 347-372; Uthus E.O., Evidency for arsenical essentiality, Environ. Geochem. Health, 1992, 14 ...

*Köttigite

in oxidized zones of arsenical ores containing zinc. The type locality is the Daniel Mine (St. Daniel Mine), Neustädtel, ...

*Anisota virginiensis

Outbreaks can be treated with an arsenical spray. Mating Eggs Larvae feeding on Quercus texana Larva Pupa Tuskes, Paul M.; P. ...

*ArsB and ArsAB transporters

Bruhn, D. F.; Li, J.; Silver, S.; Roberto, F.; Rosen, B. P. (1996-06-01). "The arsenical resistance operon of IncN plasmid R46 ...
TY - JOUR. T1 - Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. AU - Dodmane, Puttappa R.. AU - Arnold, Lora L. AU - Pennington, Karen L.. AU - Singh, Rakesh K. AU - Cardoso, Ana Paula Ferragut. AU - Cohen, Samuel Monroe. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Chronic exposure to high levels of inorganic arsenic (iAs) has been associated with cancerous and non-cancerous health effects, including cardiovascular effects. However, the mechanism for a presumed toxic effect of arsenic on vascular tissue is not clear. Our working hypothesis is that inorganic trivalent arsenic and its methylated metabolites react with cysteine-containing cellular proteins and alter their function leading to adverse events such as cytotoxicity or proliferation. In this study, human microvascular endothelial cells (HMEC1) and mouse microvascular endothelial cells (MFP-MVEC) were exposed to arsenite (iAsIII), monomethylarsonous acid (MMAIII), or dimethylarsinous acid ...
Stock Photo 4128R-18191: Download Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as spheres and are colour_coded: arsenic violet and oxygen red. Stock Photos. Search over 12 million royalty free images and rights managed stock photography
During the last decade, ATO has been used effectively to treat both newly diagnosed and relapsed APL patients, with patients showing complete remission after low dose ATO treatment [4]. The anti-cancer ability of ATO is not limited to APL [36] and many other tumors in animal models have been shown to be sensitive to ATO treatment [37, 38]. However, the lack of information on sites of action for ATO cytotoxicity in tumor types other than APL has limited its uptake for the treatment of other cancers until recent years [5].. In this study, we have demonstrated that complex IV of the ETC is a target for ATO. From a panel of ETC inhibitors, the decrease in ROS, decrease in ATP production and MMP depolarisation caused by low dose ATO treatment of T-47D cells was reproduced only by cyanide, a well characterised complex IV inhibitor (Figure 5). Direct measurement of cytochrome C oxidase activity in whole cells treated with ATO confirmed the ability of ATO to inhibit this enzyme activity directly. The ...
Citation: Ritchie, A.W., Edmonds, J.S., Goessler, W. and Jenkins, R.O. (2004) An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond. FEMS Microbiology Letters. 235 (1) pp.95-99 ...
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平成29年度「ジフェニルアルシン酸等に係る健康影響に関する調査研究」モデル動物を用いたジフェニルアルシン酸(DPAA)の生体影 ...
There are 15 Chapters to deeply display the Global Gallium Arsenide market.. Chapter 1, to describe Gallium Arsenide Introduction, product scope, market overview, market opportunities, market risk, market driving force;. Chapter 2, to analyze the top manufacturers of Gallium Arsenide, with sales, revenue, and price of Gallium Arsenide, in 2016 and 2018;. Chapter 3, to display the competitive situation among the top manufacturers, with sales, revenue and market share in 2016 and 2018;. Chapter 4, to show the Global market by regions, with sales, revenue and market share of Gallium Arsenide, for each region, from 2012 to 2018;. Chapter 5, 6, 7, 8 and 9, to analyze the key regions, with sales, revenue and market share by key countries in these regions;. Chapter 10 and 11, to show the market by type and application, with sales market share and growth rate by type, application, from 2012 to 2018;. Chapter 12, Gallium Arsenide market forecast, by regions, type and application, with sales and revenue, ...
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Cycle 1 cytarabine 10 mg/m^2 was administered subcutaneously (sc) twice daily (bid) on days 1-14. 0.25 mg/kg arsenic trioxide was administered intravenously (iv) on days 1-5 and days 8-12. Cycle 2 A second identical cycle of cytarabine and arsenic trioxide was given to patients with persistent disease. Patients who achieved complete remission (CR), complete remission with incomplete platelet count recovery (CRp), or partial remission (PR) after 1 or 2 cycles received a 14-day consolidation cycle of cytarabine and arsenic trioxide with the doses and schedule identical to the initial cycle. A recovery period of up to 4 weeks between the attainment of CR, CRp, or PR and the initiation of consolidation treatment was allowed. Patients who completed consolidation treatment started maintenance treatment of arsenic trioxide 0.25 mg/kg iv on days 1 and 4 and cytarabine 10 mg/m^2 sc bid on days 1 through 7 of a 28-day cycle ...
The purpose of this study is to study the effect of an anticancer drug, Arsenic Trioxide, in patients with small cell lung cancer who have failed at least one standard chemotherapy regimen as well as patients who are unable to tolerate the standard treatment for their cancer. The investigators seek to establish the safety of and efficacy of Arsenic Trioxide in this patient group. The study will include up to 36 participants with small cell lung cancer.. The investigators want to find out what effects, good or bad, that the study drug has on your cancer. This study will also look at specific biomarkers in your blood and in the tumor tissue which may help the investigators to determine if the levels of these biomarkers are related to tumor response to treatment.. Arsenic Trioxide, also known by the brand name, Trisenox, is a chemotherapy drug approved by the Food and Drug Administration (FDA) for the treatment of a specific type of blood cancer called Acute Promyelocytic Leukemia. It works in part ...
Arsenic Trioxide - Get up-to-date information on Arsenic Trioxide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Arsenic Trioxide
Arsenic is a highly poisonous metallic element in the nitrogen family of group Va in the periodic table. Symbol As; aomic number 33; atomic mass 74.9216; melting point ca 817°C; sublimation point ca 613°C; specific gravity 6.80 or 7.004; 5.73; valence -3, 0, +3, or +5.; electronic config. [Ar]3d104s24p3. It appears in three allotropic forms, yellow, black, and gray. The stable form is a brittle, steel-gray hexagonal solid that oxidizes rapidly in air, and at high temperatures burns to form a white cloud of arsenic trioxide. Arsenic and some arsenic compounds sublime when heated and convert to gaseous form. Arsenic is an omnipresent element as arsenic minerals in the various lithosphere or fossil fuels including realgar, orpiment, and arsenopyrite. It is prepared commercially from arsenical pyrites (sulfide ores) by condensation of sublimed gas and by the reduction of white arsenic with carbon. This element contributes hardness and is used in preparing alloys for hard and corrosion-resistant ...
JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia
JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism. Benjamin D. Bowling, Nicole Doudican, Prashiela Manga, and Seth J. Orlow, Department of Dermatology, NYU School of Medicine, New York City, New York. (Sponsored by David J. Leffell, Department of Dermatology, Yale University School of Medicine). Current standard chemotherapeutic regimens for malignant melanoma are unsatisfactory. Although in vitro studies of arsenic trioxide (ATO) have demonstrated promise against melanoma, recent phase II clinical trials have failed to show any significant clinical benefit when used as a single agent. To enhance the efficacy of ATO in the treatment of melanoma, we sought to identify compounds that potentiate the cytotoxic effects of ATO in melanoma cells. Through a screen of 2000 marketed drugs and naturally occurring compounds, and subsequent mechanistic testing, a variety of antibiotic inhibitors of ...
Description of the drug arsenic trioxide Intravenous. - patient information, description, dosage and directions. What is arsenic trioxide Intravenous!
Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk Acute Promyelocytic Leukemia (APL)
Learn about Trisenox (Arsenic Trioxide Injection) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
(2010) A., S.D.. Blood Reviews. Over the last 17years, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (As2O3) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, the role of As2O3 in front-line therapy is under investigation. Recent ...
Arsenic trioxide (As2O3) has shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells were investigated. It was found that As2O3 treatment caused both apoptosis induction and caspase-independent cell death involving mitochondrial dysfunction. This was accompanied by endoplasmic reticulum stress induction and an increase in intracellular glutathione (GSH) level. The latter was in turn prevented by the concurrent use of GSH modulator, buthionine sulfoximine but not ascorbic acid. Gene expression analysis of arsenic-resistant OVCAR-3 (OVCAR-3/AsR) cells showed the involvement of multiple factors mediating its chemoresistance. Of particular interest, a genetic hub involving elevated interleukin 1A signalling was identified. This could consecutively modulate the ...
OBJECTIVE: To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human breast cancer cell line MCF-7/ADM. METHODS: Cytotoxicity of As(2)O(3) and the sensibility to adriamycin (ADM) in MCF-7/ADM cel
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This epidemiological study investigated the association between β-cell function (a predictive factor of diabetes development) and the organic arsenic arsenobetaine (an agent less toxic to humans). Urine arsenobetaine was revealed to be associated with HOMA-β in the normal population (without diabetes), especially in males, even after adjusting for factors affecting diabetes and β-cell function, while no association was shown with HOMA-IR which is associated with insulin resistance.. Despite several conflicting results, arsenic has been reported to be correlated with diabetes in many epidemiological studies [6, 9, 23-31], and arsenic can affect insulin resistance and β-cell function [7]. In some experimental studies, arsenite was found to induce oxidative stress in pancreatic β-cells and reduce insulin transcription and secretion [32, 33], caused by the altered expression of essential genes such as the Pdx1 gene [34, 35] and insulin gene [36] for pancreas development, insulin production, and ...
An ensemble Monte Carlosimulation is used to compare high field electron transport in bulk InAs, InP and GaAs. In particular, velocity overshoot and electron transit times are examined. For all materials, we find that electron velocity overshoot only occurs when the electric field is increased to a value above a certain critical field, unique to each material. This critical field is strongly dependent on the material, about 3 kV/cm for InAs, 10 kV/cm for InP and 5 kV/cm for the case of GaAs, We find that InAs exhibits the highest peak overshoot velocity and that this velocity overshoot lasts over the longest distances when compared with GaAs and InP. Finally, we estimate the minimum transit time across a 1 μm InAs sample to be about 2 ps. Similar calculations for InP and GaAs yield 6.6 and 5.4 ps, respectively. We find that the optimal cutoff frequency for an ideal InAs based device ranges from around 79 GHz when the device thickness is set to 1 μm. We thus suggest that indium arsenide offers great
Purpose: It was recently reported that the organic arsenic compound darinaparsin (DPS) is a cytotoxin and radiosensitizer of tumor cells in vitro and in subcutaneous xenograft tumors. Surprisingly, it was also found that DPS protects normal intestinal crypt epithelial cells (CECs) from clonogenic death after ionizing radiation (IR). Here we tested the DPS radiosensitizing effect in a clinically relevant model of prostate cancer and explored the radioprotective effect and mechanism of DPS on CECs. Methods and Materials: The radiation modification effect of DPS was tested in a mouse model of orthotopic xenograft prostate cancer and of IR-induced acute gastrointestinal syndrome. The effect of DPS on CEC DNA damage and DNA damage responses was determined by immunohistochemistry. Results: In the mouse model of IR-induced gastrointestinal syndrome, DPS treatment before IR accelerated recovery from body weight loss and increased animal survival. DPS decreased post-IR DNA damage and cell death, ...
NEW ORLEANS-Two forms of arsenic are effective for inducing remissions in people with acute promyelocytic leukemia (APL), according to data presented at the ASH meeting. 1
Hydrogen passivation of Si δ-doped GaAs grown by molecular beam epitaxy. Swaminathan, V.; Asom, M. T.; Livescu, G.; Geva, M.; Stevie, F. A.; Pearton, S. J.; Lopata, J. // Applied Physics Letters;12/31/1990, Vol. 57 Issue 27, p2928 Hydrogen passivation of Si δ-doped GaAs grown by molecular beam epitaxy is studied. Just as in uniformily Si-doped GaAs, exposure of the δ-doped material to a low frequency (30 kHz) hydrogen plasma at 250 °C for 30 min deactivates the Si donors in the δ spikes. For samples with Si... ...
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Learn about the potential side effects of Trisenox (arsenic trioxide). Includes common and rare side effects information for consumers and healthcare professionals.
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial
Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.
BACKGROUND: The studies have demonstrated that arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) takes effects in treatment of acute promyelocytic leukemia (APL) through different underlying mechanisms. This has established the molecular foundation of ATO plus ATRA therapy. Currently, ATO plus ATRA has also been widely used in clinical practice. OBJECTIVE: To assess the efficacy and safety of ATO in combination with ATRA for APL. SEARCH STRATEGY: The Cochrane Library (Issue 1, 2009), Cochrane Central Register of Controlled Trials (from 1970 to January 2009), MEDLINE (from 1978 to October 2008), EMBASE (from 1950 to March 2009), Chinese Biological Medical Literature Database (from 1978 to December 2008), CNKI (from 1994 to December 2008), China Medical Academic Conference Database (from 1994 to December 2008) were electronically searched ...
Find quality suppliers and manufacturers of 1309-64-4(Diantimony trioxide) for price inquiry. where to buy 1309-64-4(Diantimony trioxide).Also offer free database of 1309-64-4(Diantimony trioxide) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
Despite the threat to human health and the environment, industrial poultry producers continue to use arsenical drugs to boost growth rates. A new study measured how much of this arsenic ends up in your meat.
From 1948 to 1975, nine out of eleven epidemiological studies show significant excess mortality from respiratory cancer among diverse occupations exposed to various inorganic arsenicals and demonstrate that such exposure is carcinogenic in three different tissues. Two of the studies show concomitant significant excess mortality from lymphatic cancer and one from skin cancer. Two studies reveal a d
Gallium Arsenide Nanoparticles / Nanopowder GaAs bulk & research qty manufacturer. Properties, SDS, Applications, Price. Free samples program. Term contracts & credit cards/PayPal accepted.
CPL 02-02-022 - CPL 2-2.22 - 29 CFR 1910.1018 Inspection and Compliance Procedures for the Permanent Occupation Exposure Standard for Inorganic Arsenic Compounds.
Nadar, Venkadesh Sarkarai; Yoshinaga, Masafumi; Pawitwar, Shashank S et al. (2016) Structure of the ArsI C-As Lyase: Insights into the Mechanism of Degradation of Organoarsenical Herbicides and Growth Promoters. J Mol Biol 428:2462-73 ...
The FODM121 series, FODM124, and FODM2701 consists of a gallium arsenide infrared emitting diode driving a phototransistor in a compact 4-pin mini-flat packag
The H11G1M and H11G2M are photodarlington-type optically coupled optocouplers. These devices have a gallium arsenide infrared emitting diode coupled with a si
POET Technologies has developed a gallium arsenide process to build electrical, optical, and electro-optical integrated circuits on one monolithic chip.
POET Technologies has developed a gallium arsenide process to build electrical, optical, and electro-optical integrated circuits on one monolithic chip.
Photocoupler of high isolation type that consists of phototransistor optically coupled to gallium arsenide infrared emitting diode in a 4-pin SO6L package. Datasheet Toshiba TLP385(D4-BLL,E)
neoarsphenamine: was MH 1963-92; NEOARSENOBENZOL & NOVARSENOBENZENE were see NEOARSPHENAMINE 1976-92; use ARSENICALS to search NEOARSPHENAMINE 1966-92; very toxic former antisyphilitic agent still used occasionally for infections, including those in animals; it produces skin sensitization & has become a tool in the study of immunologic tolerance as a hapten
A process for fabricating layered semiconductor structures, particularly thin gallium arsenide solar cells, on reusable substrates. The structure is fabricated by depositing a selectively removable layer such as gallium aluminum arsenide onto a substrate, and then depositing a solar cell basic structure on the selectively removable layer. Preferably, the solar cell basic structure includes a layer of p-type gallium arsenide on the layer of gallium aluminum arsenide, a layer of n-type gallium arsenide on the p-type gallium arsenide, and a transparent glass cover over the n-type gallium arsenide layer. The solar cell basic structure is separated from the substrate by selectively dissolving the gallium aluminum arsenide layer, and a new layer of gallium aluminum arsenide is epitaxially deposited upon the exposed face to form a thin, lightweight gallium arsenide solar cell. If the layer of p-type gallium arsenide is about 0.5 microns thick or less, the new layer of gallium aluminum arsenide may be omitted.
Until recently, chicken producers would routinely supplement poultry feed with a growth-promoting arsenical drug called roxarsone, which also treats intestinal parasites in the birds and gives their meat an appealing pink color. A study in this issue of EHP shows that inorganic arsenic (iAs) accumulates in the breast meat of broiler chickens, potentially as a result of treatment with roxarsone. In 2011 the U.S. Food and Drug Administration (FDA) found that the livers of roxarsone-treated chickens had elevated levels of iAs, a known human carcinogen. In response, roxarsones manufacturer, Pfizer, voluntarily pulled the drug off the U.S. market, although it is still sold overseas, and a similar arsenical drug is still available in the United States. Sampling for the new study took place between December 2010 and June 2011, before Pfizer withdrew roxarsone from the U.S. market. Roxarsone is an organic form of arsenic, which although less toxic to humans than the inorganic species implicated in cancer, has
Page contains details about metal-contacted gallium arsenide/indium arsenide core/shell nanowire device . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Arsenic toxicity is species-dependent for mammals and is transformed to other metabolites in various organs. In order to understand its metabolism, in-vitro simulation experiments were set up for various organ tissues. As(V) was transformed to As(III), while DMA(V) was changed to DMAS in sheep rumen, but the suspected MA-V) was not formed. This is different for the incubation of seaweed in rumen fluid, which points to a different unknown source for MA(V). In another study, dog MDCK kidney cells showed that inorganic arsenicals were methylated in kidney cells while the exposed DMAS was only oxidized to DMA(V) in kidney cells, and the exposed DMA(V) rarely transformed. The toxicities of arsenicals in dog kidney cells is dependant upon the uptake rates and the transformation of arsenicals. DMAS was as toxic as the inorganic arsenic species and an order to magnitude more toxic than the oxo-species. Methylated arsenic species can accumulate in hair and wool and can be used as a biomarker for arsenic ...
This phase III trial studies tretinoin and arsenic trioxide in treating patients with newly diagnosed acute promyelocytic leukemia. Standard treatment for acute promyelocytic leukemia involves high doses of a common class of chemotherapy drugs called anthracyclines, which are known to cause long-term side effects, especially to the heart. Tretinoin may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Arsenic trioxide may stop the growth of cancer cells by either killing the cells, by stopping them from dividing, or by stopping them from spreading. Completely removing or reducing the amount of anthracycline chemotherapy and giving tretinoin together with arsenic trioxide may be an effective treatment for acute promyelocytic leukemia and may reduce some of the long-term side effects.. See detailed information including eligibility.. ...
Arsenic biochemistry refers to biochemical processes that can use arsenic or its compounds, such as arsenate. Arsenic is a moderately abundant element in Earths crust, and although many arsenic compounds are often considered highly toxic to most life, a wide variety of organoarsenic compounds are produced biologically and various organic and inorganic arsenic compounds are metabolized by numerous organisms. This pattern is general for other related elements, including selenium, which can exhibit both beneficial and deleterious effects. Arsenic biochemistry has become topical since many toxic arsenic compounds are found in some aquifers, potentially affecting many millions of people via biochemical processes. The evidence that arsenic may be a beneficial nutrient at trace levels below the background to which living organisms are normally exposed has been reviewed. Some organoarsenic compounds found in nature are arsenobetaine and arsenocholine, both being found in many marine organisms. Some ...
A Schottky-barrier gate gallium arsenide field effect structure is made using a self-aligned gate fabrication technique. The resulting device includes source and drain regions, which are parts of a conducting channel formed through ion implantation or epitaxial growth or a combination of the two. A gate is formed on the same channel by first etching a portion of the channel between the source and the drain regions to form a gate window which then receives a Schottky-barrier gate electrode.
Page contains details about strontium sulfide/indium gallium arsenide nanocrystals . It has composition images, properties, Characterization methods, synthesis, applications and reference articles : nano.nature.com
Hundreds of millions of people world-wide are exposed to unacceptable levels of arsenic in drinking water. This is a public health crisis because arsenic is a Group I (proven) human carcinogen. Human cells methylate arsenic to monomethylarsonous acid (MMAIII), monomethylarsonic acid (MMAV), dimethylarsinous acid (DMAIII), and dimethylarsinic acid (DMAV). Although the liver is the predominant site for arsenic methylation, elimination occurs mostly in urine. The protein(s) responsible for transport of arsenic from the liver (into blood), ultimately for urinary elimination are unknown. Human multidrug resistance protein 1 (MRP1/ABCC1) and MRP2 (ABCC2), are established arsenic efflux pumps, but unlike the related MRP4 (ABCC4), are not present at the basolateral membrane of hepatocytes. MRP4 is also found at the apical membrane of renal proximal tubule cells making it an ideal candidate for urinary arsenic elimination. In the current study, human MRP4 expressed in HEK293 cells reduced the ...
2-Methoxyestradiol Induces Mitotic Arrest, Apoptosis, and Synergistic Cytotoxicity with Arsenic Trioxide in Human Urothelial Carcinoma Cells. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Arsenobetaine, arsenocholine, monomethylarsonic acid, dimethylarsinic acid, arsenous (III) acid, arsenic (V) acid. The concentration of speciated arsenics is determined by using high performance liquid chromatography (HPLC) to separate the species coupled to an ICP-DRC-MS to detect the arsenic species. This analytical technique is based on separation by anion-exchange chromatography (IC), followed by detection using quadrupole ICP-MS technology, and includes DRC™ technology (Baranov VI et al., 1999), which minimizes or eliminates many argon-based polyatomic interferences (Tanner S et al., 2000) will require 0.5 mL of urine. Arsenic species column separation is largely achieved due to differences in charge-charge interactions of each negatively-charged arsenic component in the mobile phase, with the positively-charged quaternary ammonium groups bound at the columns solid-liquid interface. Upon exit from the column, the chromatographic eluent goes through a nebulizer, where it is converted into ...
Arsenicals are relatively weak poisons and the sisters being aware of this used two poisons, strychnine and cyanide, which dwarf arsenicals in their effectiveness. (1) Even though arsenic wasnt the agent of death arsenic and old lace has a much nicer artistic ring to it then strychnine and old lace or cyanide and old lace. Regardless, arsenic is a much feared material, resulting in what Ralph Zangaro calls arsenophobia. (2). No debate arsenic is a poison, but it has been used medicinally for more than 3000 years to treat human illnesses, including infectious diseases and malignancies. In recent times, Chinese researchers reported that arsenic trioxide induced remissions in patients with promyelocytic leukemia, a cancer of the blood, including those who had relapsed after other prior therapy. (3) In another report concerning a long-term study in China, doctors may appear to have safely and successfully treated patients with cancer of the blood and bone marrow with a combination of arsenic ...
Ingestion of arsenic is relatively common in the setting of homicide and is occasionally used in deliberate self-poisoning. Arsine gas and CCA exposure are not uncommon industrial exposures. Most organs can be involved and the diagnosis may not be obvious. \\ \\ Arsenic is a classic poison; implicated in the deaths of Tchaikovsky and Napoleon. It has also been used as a therapeutic substance since ancient times. It has been used in traditional Chinese medicines and most recently as a chemotherapeutic agent for the treatment of acute promyelocytic leukaemia. Chronic arsenic poisoning is a major public health crisis and an environmental disaster in Bangladesh and West Bengal, due to the contamination of ground water that affects millions of people. These chronic problems are beyond the scope of this course. \\ \\ Arsenic exists in many forms: arsine gas, elemental arsenic, inorganic oxides and organic arsenic. Acute arsenic poisoning is rare. The elemental form of arsenic is non-toxic but the ...
Composition and optical absorption of thin films of GaAs(Ti) and GaAs, deposited by sputtering on glass substrates under different process conditions, have been investigated. The thin films obtained are typically 200 nm thick. ToF-SIMS measurements show a quite constant concentration and good uniformity of Ti profiles along the GaAs(Ti) layers in all cases and EPMA results indicate that Ti content increases with the substrate temperature in the sputtering process. Measurements of the transmittance and reflectance spectra of the GaAs and GaAs(Ti) thin films have been carried out. In the optical characterization of the films it is found that optical absorption is enhanced in all samples containing Ti. The determination of the optical gap from the optical absorption, shows optical gap variations from 1.15 to 1.29 eV in the GaAs thin films, and from 0.83 to 1.13 eV in the GaAs(Ti) thin films. The differences in absorption and EgTAUC observed between samples of GaAs and GaAs(Ti) are consistent with ...
Orpiment is mainly used externally as louse-killer, a cure for scabies, for snake bites, insect stings, and skin diseases (Pharmacopeia of China, 2005; Koch et al., 2007). Orpiment is included in Quingyi Piwen Dan, a preparation of detoxication and laxative use with other 74 herbs, but its use alone in oral remedies is not common. Nanoparticles of orpiment have been prepared, and they were effective in killing leukemia K562 cells in vitro (Lin et al., 2007). [...] Realgar is less toxic as compared to arsenic trioxide, and is now used alone or in combination for hematologic malignancies (Lu et al., 2002; Shen et al., 2004). Recently, Realgar-Indigo naturalis formulae have been shown to be very effective against promyelocytic leukemia (Wang et al., 2008). Realgar acts as the principal component of the formula, whereas other plant active ingredients (such as indirubin and trashinone IIA) serve as adjuvant ingredients, in inducing acute promyelocytic leukemia cell differentiation and the ...
Learn about symptoms and treatments for acute promyelocytic leukemia (APL), a cancer in which the bone marrow produces too many promyelocytes.
Treatment of acute promyelocytic leukemia (APL), the M3 subtype of acute myeloid leukemia (AML), differs from the usual AML treatment. Learn more here.
This report describes a unique case of acute promyelocytic leukemia (APL) showing elusive morphologic features, an atypical pattern of cytochemical reactions, and a previously unreported immunophenotype consistent with a very early myeloid form: CD13
Compare risks and benefits of common medications used for Acute Promyelocytic Leukemia. Find the most popular drugs, view ratings, user reviews, and more...
This application note demonstrates the ability to measure various arsenic forms in white rice, building upon previous work using HPLC/ICP-MS. The results described demonstrate that the combination of Flexar HPLC and NexION ICP-MS is suitable for the analysis of different forms of arsenic in white rice.
Rabbit Polyclonal to ACRO (H chain, Cleaved-Ile43) TL may become an effective restorative agent for the treatment of MDS (25), several 162808-62-0 types of human being pancreatic (26) and adrenal (27) malignancy, and Capital t cell lymphocytic leukemia (28) via inducing cell apoptosis through the service of caspase-3 and generation of reactive oxygen varieties (ROS) (25C27). Although particular combination treatments including As2O3 and additional providers, are ongoing for several types of human being tumor, few As2O3 combination treatments are clinically effective. These include combination therapy of As2O3 with ascorbic acid in nonrefractory APL hematologic malignancies and multiple myeloma (18), but not in additional AML except nonrefractory APL, acute lymphoid leukemia (18), chronic myeloid leukemia and chronic lymphoid leukemia (18). The use of phase 2 combination therapy with 162808-62-0 As2O3 and gemtuzumab ozogamicin for the treatment of MDS and secondary AML offers been found to have ...
There were no treatment-related effects on mortality. In most cases there were no effects on body weight although in one replicate experiment a decrease in weight was observed in the high dose group and body weight gain was decreased over the 2 week post-exposure. Spleen weights were increased in all gallium arsenide treated groups while thymus weights were decreased at the high dose (Table 1). A dose-response increase in lung weights occurred following treatment but none of the individual values were significant. The lungs were characterized by darkened areas consisting of lymphocyte and macrophage infiltration. There was a tendency (not significant) for a treatment-related decrease in peripheral leukocyte counts (Table 1) which was associated with a significant decrease in peripheral lymphocyte counts in the 200 mg/kg treatment group (not shown).. The immune and bone marrow studies are also summarized in Table 1. Gallium arsenide suppressed the following immune parameters dose- dependently: ...
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The authors estimated the global burden of disease for bladder, lung, and skin cancers attributable to inorganic arsenic in food. The authors - 1) established dose response estimates by converting dose response estimates for water exposure to human dose; 2) estimated exposure using data on a common range of arsenic content for food crops grown in different parts of the world and dietary patterns in different parts of the world; 3) multiplied the dose-response slope factor with the estimated range of daily dietary inorganic arsenic exposure to characterize cancer risk; and 4) summed across different populations to estimate the global burden of a particular arsenic-induced cancer ...
This blood test is used to measure Arsenic levels. Arsenic is a common cause of acute poisoning through heavy metals. Arsenic enters the environment through the smelting of copper, zinc and lead and is released through the manufacturing of certain chemicals. Pesticides that contain arsenic, when manufactured, release arsine gas. Arsenic has been found in water supplies around the world, which has the potential to leach into seafood. Arsenic is found in rat poisoning, fungicides and products used to protect wood. Arsenic toxicity affects the blood, kidneys, skin, digestive tract and central nervous system ...
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Purpose: Arsenic trioxide (ATO) induces B-cell chronic lymphocytic leukemia (B-CLL) cell apoptosis in vitro. We sought to study the mechanism involved in this effect and whether ATO is suitable for combination therapies with protein kinase inhibitors.. Experimental Design: B-CLL cells were isolated from the peripheral blood of 28 patients. Cell viability studies with ATO alone or in combination with kinase inhibitors were done by flow cytometry, Western blotting, and immunofluorescence analyses.. Results: After 48 hours, 3 μmol/L ATO induced apoptosis (average 75%) in all B-CLL samples studied and with minimal effect on normal peripheral blood lymphocytes. Apoptosis entailed Akt and NF-κB inactivation, XIAP downregulation, and PTEN upregulation, thus implying inhibition of the phosphoinositide 3-kinase (PI3K) survival pathway. Indeed, the combination of ATO and PI3K inhibitors increased the apoptotic effect of either agent alone. ATO also induced c-jun-NH2 terminal kinase (JNK) activation, and ...
The S-phase kinase associated protein 2 (Skp2), a member from the F-box protein family, regulates cell cycle progression and is highly expressed in pancreatic cancer (PC). cells [19]. To further investigate whether ATO enhanced the level of sensitivity of Personal computer cells to GEM, we used the MTT assay to evaluate viability of treated Patu8988 and Panc-1 cells. PC cells were simultaneously treated with either each drug alone or a combination of both medicines for 48 h. We found that the combined treatment of 3 M ATO and 20 M GEM caused more significant growth inhibition than 3 M ATO or 20 M GEM alone in Personal computer cells (Number 1). These findings suggested that a combination of ATO and GEM significantly improved the level of sensitivity of Personal computer cells to GEM. Open in a separate windowpane Number 1 The antitumor effect of combined treatment with ATO and GEM. Pancreatic malignancy cells were treated with either 3 M arsenic trioxide (ATO) or 20 M GEM, or co-treated with 3 M ...
2000, describes a method for removing arsenic from fly ash, in which arsenic is recovered as scorodite. The first treatment stage of the arsenic-containing material is the oxidation of trivalent arsenic (As(lll)) into pentavalent arsenic (As(V)) with a gas containing sulphur dioxide and oxygen in oxidising conditions, in which arsenic does not precipitate. After this, arsenic is precipitated in atmospheric conditions, in which the Fe(III)/As(V) mole ratio is specified as 1. Precipitation is carried out either in one or several stages, but precipitation as scorodite demands the over-saturation of the solution, which is achieved by recycling scorodite crystals to the first precipitation reactors and simultaneously neutralising the suspension. A beneficial pH range is around 1-2 and this is maintained by feeding a suitable neutralising agent into the precipitation stage. In these conditions, arsenic can be precipitated to the level of 0.5 g/l. The final arsenic removal to a level below 0.1 mg/l is ...
A recent study done at Queens University (1) in Belfast found high levels of illegal, inorganic arsenic in many baby rice food products. A professor at the university stated, "this research has shown direct evidence that babies are exposed to illegal levels of arsenic despite the EU regulation to specifically address this health challenge. Babies are particularly vulnerable to the damaging effects of arsenic that can prevent the healthy development of a babys growth, IQ and immune system to name but a few." Babies require constant care and appropriate nutrients to aid healthy growth, but if youre feeding them harmful things such as inorganic arsenic, they could cause a range of health problems in the future such as developmental problems, heart disease, diabetes and nervous system damage. ...
The FDA has released a report on arsenic in rice. Testing is underway to study the amounts of arsenic, in micrograms, present in rice and rice products.
The National Institute of Standards and Technology (NIST) uses its best efforts to deliver a high quality copy of the Database and to verify that the data contained therein have been selected on the basis of sound scientific judgment. However, NIST makes no warranties to that effect, and NIST shall not be liable for any damage that may result from errors or omissions in the Database ...
For patient information click here Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2] Grammar Reviewer: Natalie Harpenau, B.S.[3] Synonyms and Keywords: Acute progranulocytic leukemia; APL; AML with t(15;17)(q22;q12); PML-RARA and variants; FAB subtype M3; M3 variant ...
Molecular response in acute promyelocytic leukemia: a direct comparison of regular and real-time RT-PCR. Liu, Y.-F.; Zhu, Y.-M.; Shen, S.-H.; Shen, Z.-X.; Li, J.-M.; Chen, S.-J.; Chen, Z.; Jiong, H. U. // Leukemia (08876924);Aug2006, Vol. 20 Issue 8, p1393 Evaluation of molecular response is important for the diagnosis and monitoring of minimal residual disease in patients with acute promyelocytic leukemia (APL). In this study, we analyzed the molecular response by regular reverse transcription-polymerase chain reaction (RT-PCR) and quantitative... ...
Cancer Therapy Advisor provides hematology professionals with the latest hematology conditions, procedures and guides for different surgical and non surgical conditions. Visit often for updates and new information.
Using ab initio methods (generalized valence bond with small clusters to represent the surface), we have studied reconstruction of the GaAs (110) surface and the initial steps of oxidation. The relaxation of the surface atoms (26° twist angle) is found to be in good agreement with the results of recent LEED experiments (27°±2° twist angle). The results indicate that the reconstruction is dominated by hybridization effects of orbitals localized at the surface. The calculations of chemisorbed O2 and O support the following picture: (i) Molecular O2 can bond only weakly (physisorb) to the perfect GaAs(110) surface. Chemisorption of the O2 requires a defect site which may then catalyze decomposition of the O2. (ii) There is an intermediate oxidized state at low coverages (before O is inserted in the GaAs bonds) in which O atom is chemisorbed to a surface As (donor-acceptor bond). For this intermediate oxide we calculate chemical shifts of 2.6 eV (deeper) in the 3d levels of the surface As and ...
Power for the X-37B while its in orbit comes from the sun. The Air Force says the space plane is equipped with gallium arsenide solar cells and lithium ion bat... - Page 6
8.4 II.8.4 Arsenic compounds and other inorganic poisons by Sinichi Suzuki and Yasuhiro Suzuki Introduction The Wakayama Curry Poisoning Incident taking place in August 1998, followed by various...
Arsenic Poisoning Arsenic poisoning, happens when a person takes in dangerous levels of arsenic. Arsenic is a natural semi-metallic chemical that is found
A two-year old report suggested that one type of bacteria could survive by assimilating arsenic - a finding that held implications for the search for life in the cosmos. But new research contradicts those conclusions.
Progress in the development of effective novel therapeutics for treatment of acute myeloid leukemia (AML) has been generally disappointing, and clinical outcomes remain generally suboptimal. The notable exception to this trend is the remarkable advances seen in acute promyelocytic leukemia (APL), with remission and long-term survival rates improving from less than 15% to greater than 90% over the past 50 years (1). These improvements occurred following the recognition of APL as a clinical entity distinct from other forms of AML, with different underlying biology and hence potential unique therapeutic sensitivities. Although mechanistic understanding of successful targeted therapy in APL occurred after clinical success, it did provide a template for how improved disease definition into subgroups based on underlying etiology rather than phenotype may provide opportunities for targeted intervention. It is now clear that APL is not a special case, and that earlier morphology and cytogenetic-based ...
The discussion on arsenic in the environment is complex and must grasp the importance of very many, mostly unrelated works on individual aspects. This volume represents one of the first comprehensive and interdisciplinary examinations into arsenics…
Reportedly Cary Grant was later unhappy with his acting in this film, thinking it hackneyed and completely over the top. Indeed his performance is over the top, as is nearly everything else in this film. Based on a long-running Broadway play, the overall direction is stagey, all the acting is overdone, the villains are cartoonish, and the supposedly suspenseful scenes are far from scary. But these are not actually reasons to avoid this delightful little film. Light entertainment, yes, but entertaining nevertheless.. ...
Managing Arsenic in the Environment by Ravi Naidu, Euan Smith, Gary Owens, Prosun Bhattacharya, Peter Nadebaum published February 2006. The ISBN is 9780643093515. The publisher is CSIRO Publishing. Buy Managing Arsenic in the Environment from CSIRO PUBLISHING online.
[150 Pages Report] Check for Discount on 2016 Online Arsenic Analyzer Global Market Report report by Prof Research. The Global and Chinese Online Arsenic Analyzer Industry, 2011-2021...
Disclosed herein is a process to remove arsenic from fluorospar. The process comprises treating the fluorospar to convert the arsenic impurity to a mag...
3D CAE Extensions - oferă opțiuni pentru testare și optimizarea produselor, îmbunătățind performanțele structurale, termice și dinamice în timpul proiectării produsului.
Research carried out at the University of Gothenburg may lead to more effective arsenic-containing drugs. The results may also lead to more resistant plants, and crops with a limited absorption and storage of arsenic.
Are you worried about the potentially harmful levels of Arsenic - lurking in Vibreant Greens? In this article, we reveal the hidden truths behind…
Jane Austen may have been poisoned by arsenic, according to historians who have been trying to unravel the mysterious death of the novelist, who died at age 41 in 1817.
Ato is a five year old boy from Accra in need of OHS. Please contact [email protected] for further information of the most recent echo reports. Many thanks for any help that you can provide ...
Type poison (ingested); Save Fortitude DC 13. Onset 10 minutes.; Frequency 1/minute for 4 minutes. Effect 1d2 Con damage; Cure 1 save. ...
Looking for online definition of dimethylarsinic acid in the Medical Dictionary? dimethylarsinic acid explanation free. What is dimethylarsinic acid? Meaning of dimethylarsinic acid medical term. What does dimethylarsinic acid mean?
In 2013 FSANZ released a survey on the levels of inorganic arsenic in a range of seaweed types and products containing seaweed, available in Australia.. The levels in most seaweed tested were below the regulatory limit for inorganic arsenic, with the exception of one hijiki seaweed sample. Because this sample was made up of two individual samples of the same brand of hijiki it may not be representative of all hijiki seaweed available for sale in Australia. Hijiki seaweed is also tested at the border for inorganic arsenic and compliance rates are high.. The New Zealand Ministry for Primary Industries (MPI) has also conducted tests on levels of arsenic in imported hijiki products and found some levels exceeding the regulatory limit for inorganic arsenic.. Using the information collected on the levels of inorganic arsenic in seaweed, dietary exposure to inorganic arsenic was estimated for the Australian population. Using the median inorganic arsenic concentrations in seaweed, the contribution of ...
Cure ARSENICUM ALBUM [Ars] Bangalore, A2Z Polyclinic, A to Z Polyclinic is a Trusted Polyclinic specializing in Treatment of ARSENICUM ALBUM [Ars] located in bangalore offering Treatment Services through Homeopathy, Ayurveda, Naturopathy, Hypnotherapy, Meditation and Modern Medicine.
Inorganic arsenic is used for hardening copper and lead alloys. It also is used in glass manufacturing as a decolorizing and refining agent, as a component of electrical devices, in the semiconductor industry, and as a catalyst in the production of ethylene oxide. Arsenic compounds are used as a mordant in the textile industry, for preserving hides, as medicinals, pesticides, pigments, and wood preservatives. Approximately 90% of the domestic consumption of arsenic is currently used with production of chromated copper arsenate (CCA), a wood preservative, the production of which is currently being phased out. Arsenic is also found naturally in the environment and is typically present in soil and water at detectable levels. Sources of human exposure to inorganic arsenic include drinking water, diet, air, and soils (which can contain naturally occurring arsenic or contamination from anthropogenic sources). This draft IRIS health assessment addresses only cancer human health effects that may result ...
TY - JOUR. T1 - Recent advances in Philadelphia chromosome-positive malignancies. T2 - the potential role of arsenic trioxide.. AU - ODwyer, Michael E.. AU - La Rosée, Paul. AU - Nimmanapalli, Ramedivi. AU - Bhalla, Kapil N.. AU - Druker, Brian. PY - 2002/4. Y1 - 2002/4. N2 - Chronic myelogenous leukemia (CML) is characterized by the presence of the Bcr-Abl fusion gene, which encodes a constitutively active tyrosine kinase that has been strongly implicated as the sole oncogenic abnormality in early-stage CML. Treatment with the specific tyrosine kinase inhibitor imatinib mesylate has achieved excellent results in CML, at all stages of the disease. However, limitations to the successful use of imatinib mesylate as a single agent include the problem of resistance, seen chiefly in patients with advanced-phase disease. This review summarizes the clinical results to date with imatinib mesylate and briefly discusses the problem of resistance before describing potential strategies, including the use ...
Exposure to arsenic has been linked to a variety of adverse human health effects, including skin lesions; skin, lung, and bladder cancer; vascular diseases; low birth weight; and potentially diabetes mellitus and increased susceptibility to infection [1-3]. Although human exposure to the more toxic, inorganic forms of arsenic is thought to occur primarily through drinking water [3, 4], elevated concentrations of arsenic in certain foods may pose an additional risk to consumers (e.g., [2]). Foods with particularly high total arsenic concentrations include fish and seafood [5-9]; cereals and cereal products, particularly rice and rice-based products [5-7, 10, 11]; and bran and germ [2]. Using diet data and physiological models to estimate total arsenic exposure, Xue et al. [12] found that fruits and fruit juices, vegetables, and beer and wine also can be important sources of dietary arsenic; more recent studies document high arsenic concentrations in cruciferous vegetables in particular [13]. ...
TY - JOUR. T1 - Association of cardiometabolic genes with arsenic metabolism biomarkers in American Indian communities. T2 - Environmental Health Perspectives. AU - Balakrishnan,Poojitha. AU - Vaidya,Dhananjay. AU - Franceschini,Nora. AU - Saroja Voruganti,V.. AU - Gribble,Matthew O.. AU - Haack,Karin. AU - Laston,Sandra. AU - Umans,Jason G.. AU - Francesconi,Kevin A.. AU - Goessler,Walter. AU - North,Kari E.. AU - Lee,Elisa. AU - Yracheta,Joseph. AU - Best,Lyle G.. AU - Maccluer,Jean W.. AU - Kent,Jack. AU - Cole,Shelley A.. AU - Navas-Acien,Ana. PY - 2017/1/1. Y1 - 2017/1/1. N2 - Background: Metabolism of inorganic arsenic (iAs) is subject to inter-individual variability, which is explained partly by genetic determinants. oBjectives: We investigated the association of genetic variants with arsenic species and principal components of arsenic species in the Strong Heart Family Study (SHFS). Methods: We examined variants previously associated with cardiometabolic traits (~ 200,000 from Illumina ...

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells<...Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells<...

Dodmane, PR, Arnold, LL, Pennington, KL, Singh, RK, Cardoso, APF & Cohen, SM 2015, Effect of trivalent arsenicals on cell ... Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. / Dodmane, Puttappa R. ... Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. In: Toxicology Reports ... Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. Toxicology Reports. ...
more infohttps://nebraska.pure.elsevier.com/en/publications/effect-of-trivalent-arsenicals-on-cell-proliferation-in-mouse-and

Permeation of roxarsone and its metabolites increases caco-2 cell proliferationPermeation of roxarsone and its metabolites increases caco-2 cell proliferation

4] Calvert, C.C. (1975) Arsenicals in animal feeds and wastes. In: Woolson, E.A. Ed., Arsenical Pesticides, American Chemical ...
more infohttps://m.scirp.org/papers/35667

Arsenical Keratosis: Background, Pathophysiology, EtiologyArsenical Keratosis: Background, Pathophysiology, Etiology

encoded search term (Arsenical Keratosis) and Arsenical Keratosis What to Read Next on Medscape. Related Conditions and ... arsenical keratosis in 7.1%, and skin cancers in 1.5%. Of the 428 people with skin cancer, 72% also presented with arsenical ... Arsenical keratosis is not a fatal disease, but it may persist indefinitely and can become bothersome over time because of pain ... Arsenical cancer of skin. Histologic study with special reference to Bowens disease. Cancer. 1968 Feb. 21(2):312-39. [Medline] ...
more infohttps://emedicine.medscape.com/article/1099882-overview

Arsenical copper - WikipediaArsenical copper - Wikipedia

Arsenical copper contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced ... Arsenical bronze Rollason, EC (1949). Metallurgy for Engineers (2nd ed.). London: Arnold. "Archived copy". Archived from the ... Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. ...
more infohttps://en.wikipedia.org/wiki/Arsenical_copper

Arsenical keratosis - WikipediaArsenical keratosis - Wikipedia

An arsenical keratosis is a growth of keratin on the skin caused by arsenic, which occurs naturally in the earths crust and is ... Arsenical keratoses may persist indefinitely, and some may develop into invasive squamous cell carcinoma. Metastatic arsenic ... ISBN 0-7216-2921-0. Yerebakan O, Ermis O, Yilmaz E, Basaran E (February 2002). "Treatment of arsenical keratosis and Bowens ... Topical 5-fluorouracil cream or 5% imiquimod cream may be useful in treating arsenical keratoses and Bowens disease. Freedberg ...
more infohttps://en.wikipedia.org/wiki/Arsenical_keratosis

Aliphatic organic arsenicals - definition of aliphatic organic arsenicals by The Free DictionaryAliphatic organic arsenicals - definition of aliphatic organic arsenicals by The Free Dictionary

aliphatic organic arsenicals synonyms, aliphatic organic arsenicals pronunciation, aliphatic organic arsenicals translation, ... English dictionary definition of aliphatic organic arsenicals. aliphatic straight chain of carbon atoms of a propane molecule ... redirected from aliphatic organic arsenicals). Also found in: Thesaurus, Medical, Encyclopedia. aliphatic. straight chain of ... Aliphatic organic arsenicals - definition of aliphatic organic arsenicals by The Free Dictionary https://www.thefreedictionary. ...
more infohttps://www.thefreedictionary.com/aliphatic+organic+arsenicals

Arsenical Keratosis Clinical Presentation: History, Physical Examination, ComplicationsArsenical Keratosis Clinical Presentation: History, Physical Examination, Complications

encoded search term (Arsenical Keratosis) and Arsenical Keratosis What to Read Next on Medscape. Related Conditions and ... Another type of arsenical keratosis seen in most patients with arsenical cancers manifests as scaly erythematous or pigmented ... Arsenical Keratosis Clinical Presentation. Updated: Apr 02, 2018 * Author: Chih-Shan Jason Chen, MD, PhD; Chief Editor: Dirk M ... Arsenical keratoses are usually multiple and typically occur at sites of friction and trauma, especially on the palms and the ...
more infohttps://emedicine.medscape.com/article/1099882-clinical

Chemical Database: Arsenical pesticides (EnvironmentalChemistry.com)Chemical Database: Arsenical pesticides (EnvironmentalChemistry.com)

This page contains information on the chemical Arsenical pesticides including: 10 synonyms/identifiers; U.S. Code of Federal ... Arsenical pesticide, liquid*Arsenical pesticide, liquid, poisonous*Arsenical pesticide, liquid, toxic*Arsenical pesticide, ... Arsenical pesticides*Arsenical pesticides, liquid, flammable, toxic, flash point less than 23 degrees C*Arsenical pesticides, ... Arsenical pesticides, solid, toxic*Arsenical pesticides, toxic. 49 CFR 172.101 - Hazardous Materials Table. Hazardous materials ...
more infohttps://environmentalchemistry.com/yogi/chemicals/cn/Arsenical%A0pesticides.html

Impact of Inorganic Arsenicals on Vegetative Growth of Two Pakistani Origins Sunflower CultivarsImpact of Inorganic Arsenicals on Vegetative Growth of Two Pakistani Origins Sunflower Cultivars

Inorganic arsenicals impact on vegetative growth of two sunflower (Helianthus annuus L.) cultivars (FH-385 as Hybrid 1 and FH- ... Impact of Inorganic Arsenicals on Vegetative Growth of Two Pakistani Origins Sunflower Cultivars. Muhammad Asif Imran,1 Feroza ...
more infohttps://www.hindawi.com/journals/jchem/2015/275830/abs/

Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells | Environmental XPRTAccumulation and toxicity of monophenyl arsenicals in rat endothelial cells | Environmental XPRT

Article Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells. Clark 1 (diphenylarsine chloride) and ... Please sign in or create your free account to view the content of Accumulation and toxicity of monophenyl arsenicals in rat ... Accumulation and toxicity of monophenyl arsenicals in rat ... You have requested access to an area of the website which ...
more infohttps://www.environmental-expert.com/articles/accumulation-and-toxicity-of-monophenyl-arsenicals-in-rat-endothelial-cells-5054/full-article

Monosodium Methanearsonate (MSMA), an Organic Arsenical | Ingredients Used in Pesticide Products | US EPAMonosodium Methanearsonate (MSMA), an Organic Arsenical | Ingredients Used in Pesticide Products | US EPA

Background - Organic Arsenical Pesticides. MSMA is an organic arsenical, a class of herbicides that also includes DSMA, CAMA, ... Monosodium Methanearsonate (MSMA), an Organic Arsenical. Monosodium methanearsonate (MSMA) is an organic arsenical pesticide ... Following application, organic arsenicals like MSMA convert over time to a more toxic form in soil (inorganic arsenic) and can ... The Organic Arsenicals; Amendments to Terminate Uses; Amendment to Existing Stocks Provisions - FR Notice, March 27, 2013 ...
more infohttps://www.epa.gov/ingredients-used-pesticide-products/monosodium-methanearsonate-msma-organic-arsenical

ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS | Science Inventory | US EPAACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS | Science Inventory | US EPA

ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS. Contact. National Health and Environmental Effects Research ... ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED TRIVALENT ARSENICALS. Z Drobna1, I Jaspers2, D J Thomas3 and M Styblo1. ... Western blot analyses of the MAPK enzyme family in cells exposed to trivalent arsenicals showed a significant increase in p-ERK ... ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS. Presented at Society of Toxicology, Nashville, TN, March 17-21, ...
more infohttps://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=62228&keyword=IAS+AND+17&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=90556721&CFTOKEN=93772159

arsB - Arsenical-resistance protein - Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) - arsB gene & proteinarsB - Arsenical-resistance protein - Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) - arsB gene & protein

Arsenical-resistance proteinImported. ,p>Information which has been imported from another database using automatic procedures ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... tr,B0TB51,B0TB51_HELMI Arsenical-resistance protein OS=Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) OX=498761 GN= ...
more infohttps://www.uniprot.org/uniprot/B0TB51

Effects of arsenicals on the DMI-induced reduction of C | Open-iEffects of arsenicals on the DMI-induced reduction of C | Open-i

Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A) ... f5: Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A ... f5: Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A ... Cells were treated 1 day after confluence with DMI in the absence (control) or presence of arsenicals. Vehicle, growth medium ...
more infohttps://openi.nlm.nih.gov/detailedresult.php?img=PMC3569692_ehp.1205731.g005&req=4

Trivalent arsenicals are bound to proteins during reductive methylation. - Semantic ScholarTrivalent arsenicals are bound to proteins during reductive methylation. - Semantic Scholar

... and pentavalent arsenicals (MMA(V) and DMA(V)) were present as end products of metabolism, rather than intermediates. We also ... but not pentavalent arsenicals were bound to proteins in vitro, it was deduced that arsenic metabolites bound to proteins ... The relative ratios of the three arsenicals changed depending on organ, fraction (HMW and SED), and time. Since the arsenic ... Raman spectra of thiolated arsenicals with biological importance.. *Mingwei Yang, Yuzhen Sun, +4 authors Yong Cai ...
more infohttps://www.semanticscholar.org/paper/Trivalent-arsenicals-are-bound-to-proteins-during-Naranmandura-Suzuki/0030b20b49fcd20afcc29712294c94f463d1a707

Mandibular Bone and Soft Tissues Necrosis Caused by an Arsenical Endodontic Preparation Treated with Piezoelectric DeviceMandibular Bone and Soft Tissues Necrosis Caused by an Arsenical Endodontic Preparation Treated with Piezoelectric Device

... A. ... describes a case of wide mandibular bone necrosis associated with significant soft tissues injury after using an arsenical ...
more infohttps://www.hindawi.com/journals/crid/2013/723753/abs/

Plus itPlus it

... have increased uptake of methylated arsenicals, which leads to increased cytotoxicity, as compared with inorganic arsenicals. ... The Novel Arsenical Darinaparsin Is Transported by Cystine Importing Systems. Nicolas Garnier, Geneviève G. J. Redstone, ... The Novel Arsenical Darinaparsin Is Transported by Cystine Importing Systems Message Subject (Your Name) has forwarded a page ... Here, we propose this route of cell entry may also exist for arsenicals and is likely to be specific to cysteine-S-conjugated ...
more infohttp://molpharm.aspetjournals.org/content/85/4/576

Fjoh 2991 - Arsenical-resistance protein - Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) - Fjoh 2991 gene &...Fjoh 2991 - Arsenical-resistance protein - Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) - Fjoh 2991 gene &...

Arsenical-resistance proteinImported. ,p>Information which has been imported from another database using automatic procedures ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... tr,A5FFK0,A5FFK0_FLAJ1 Arsenical-resistance protein OS=Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) OX= ...
more infohttps://www.uniprot.org/uniprot/A5FFK0

The arsD gene encodes a second trans-acting regulatory protein of the plasmid-encoded arsenical resistance operon.  - PubMed -...The arsD gene encodes a second trans-acting regulatory protein of the plasmid-encoded arsenical resistance operon. - PubMed -...

The arsD gene encodes a second trans-acting regulatory protein of the plasmid-encoded arsenical resistance operon.. Wu J1, ... The plasmid-encoded arsenical resistance (ars) operon produces resistance to trivalent and pentavalent salts of arsenic and ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/8326869?dopt=Abstract

Arsenicals - Pharmacology - ALPF Medical ResearchArsenicals - Pharmacology - ALPF Medical Research

Arsenicals. Last Updated on Mon, 13 Nov 2017 , Pharmacology Melarsoprol (trivalent) and tryparsamide (pentavalent) are organic ... The arsenicals are trypanocidal. Melarsoprol is highly active against all stages of trypanosomiasis, but its toxicity restricts ...
more infohttps://www.alpfmedical.info/pharmacology/arsenicals.html

Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump | Biochemical JournalAntimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump | Biochemical Journal

Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump. Adrian R. WALMSLEY, Tongqing ... The ArsA ATPase is the catalytic subunit of the pump protein, coupling the hydrolysis of ATP to the movement of arsenicals and ... Abbreviations used: ArsAB, Escherichia coli arsenical pump; Sb(III), antimonite (i.e. potassium antimonyl tartrate); ABC, ATP- ... Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump ...
more infohttp://www.biochemj.org/content/360/3/589

Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial, International...Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial, International...

"Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial, International ... Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial. Elliott, M.A.; Ford ... Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I... Elliott, M.A.; Ford, S.J.; ... A peptide trivalent arsenical inhibits tumour angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells ...
more infohttps://www.deepdyve.com/lp/elsevier/pharmaceutical-development-of-the-novel-arsenical-based-cancer-N40O9z0qQa

Welcome to CDC stacks | Silver-Catalyzed Oxidative Leaching of an Arsenical Copper Sulfide Concentrate; Bureau of Mines Report...Welcome to CDC stacks | Silver-Catalyzed Oxidative Leaching of an Arsenical Copper Sulfide Concentrate; Bureau of Mines Report...

"A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by ... The Bureau of Mines investigated a silver-catalyzed oxidative procedure for leaching an arsenical copper sulfide concentrate ... Silver-Catalyzed Oxidative Leaching of an Arsenical Copper Sulfide Concentrate; Bureau of Mines Report of Investigations -1987 ... Calcium chloride-oxygen leaching and metals recovery from an arsenical copper-cobalt concentrate ...
more infohttps://stacks.cdc.gov/view/cdc/10702

Arsenical stomatitis synonyms, arsenical stomatitis antonyms - FreeThesaurus.comArsenical stomatitis synonyms, arsenical stomatitis antonyms - FreeThesaurus.com

Antonyms for arsenical stomatitis. 4 words related to stomatitis: inflammation, redness, rubor, vesicular stomatitis. What are ... Arsenical stomatitis synonyms, arsenical stomatitis antonyms - FreeThesaurus.com https://www.freethesaurus.com/arsenical+ ... redirected from arsenical stomatitis). Also found in: Dictionary, Medical, Encyclopedia. #vtZoom,.vt-link{cursor:pointer} .vt- ... www.freethesaurus.com/arsenical+stomatitis,FreeThesaurus.com,/a,,/div, ,!--End of Graphic Thesaurus by FreeThesaurus.com--,. ...
more infohttps://www.freethesaurus.com/arsenical+stomatitis
  • The ArsA ATPase is the catalytic subunit of the pump protein, coupling the hydrolysis of ATP to the movement of arsenicals and antimonials through the membrane-spanning ArsB protein. (biochemj.org)
  • A) Effects of various arsenicals on the expression of CHOP10 protein in the early stage of adipogenesis. (nih.gov)
  • Melarsen oxide, one of the arsenical drugs often administered to people with African sleeping sickness, can lose effectiveness due to the presence of three compounds: adenine, adenosine and dipyridamole. (readabstracts.com)
  • Cells were treated 1 day after confluence with DMI in the absence (control) or presence of arsenicals. (nih.gov)
  • Previous reports have shown a much higher incidence of fatal metastases among patients with arsenical squamous cell carcinoma. (medscape.com)
  • The detection method developed by FIU researchers provides the first method for direct sensing of organic arsenicals. (fiu.edu)
  • In response to consumer concerns, U.S. manufacturers of arsenical wood preservative began a voluntary transition from CCA to other wood preservatives for certain residential wood products. (cdc.gov)
  • Western blot analyses of the MAPK enzyme family in cells exposed to trivalent arsenicals showed a significant increase in p-ERK but not in p-JNK or in p-p38 levels. (epa.gov)
  • This paper describes a case of wide mandibular bone necrosis associated with significant soft tissues injury after using an arsenical endodontic preparation in the right lower second molar for endodontic purpose. (hindawi.com)
  • Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (nih.gov)