Arsenic
A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
Arsenic Poisoning
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
Melarsoprol
Ion Pumps
Arsenite Transporting ATPases
Antimony
Trypanocidal Agents
Dimercaprol
Pentamidine
Oxides
Aquaglyceroporins
Bowen's Disease
A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)
Water Pollutants, Chemical
Nucleoside Transport Proteins
Methylation
R Factors
Methyltransferases
Trypanosoma brucei brucei
Glutathione
Trypanosoma
Organometallic Compounds
Spectrophotometry, Atomic
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Sulfides
Medicine, Traditional
Operon
Multienzyme Complexes
Urinary Bladder
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Adenosine Triphosphatases
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Carcinogens
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Environmental Exposure
Drug Resistance, Microbial
Disulfides
Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (1/1135)
Primary blasts of a t(11;17)(q23;q21) acute promyelocytic leukaemia (APL) patient were analysed with respect to retinoic acid (RA) and arsenic trioxide (As2O3) sensitivity as well as PLZF/RARalpha status. Although RA induced partial monocytic differentiation ex vivo, but not in vivo, As203 failed to induce apoptosis in culture, contrasting with t(15;17) APL and arguing against the clinical use of As203 in t(11;17)(q23;q21) APL. Prior to cell culture, PLZF/RARalpha was found to exactly co-localize with PML onto PML nuclear bodies. However upon cell culture, it quickly shifted towards microspeckles, its localization found in transfection experiments. Arsenic trioxide, known to induce aggregation of PML nuclear bodies, left the microspeckled PLZF/RARalpha localization completely unaffected. RA treatment led to PLZF/RARalpha degradation. However, this complete PLZF/RARalpha degradation was not accompanied by differentiation or apoptosis, which could suggest a contribution of the reciprocal RARalpha/PLZF fusion product in leukaemogenesis or the existence of irreversible changes induced by the chimera. (+info)NADPH oxidase inhibition does not interfere with low PO2 transduction in rat and rabbit CB chemoreceptor cells. (2/1135)
The aim of the present work was to elucidate the role of NADPH oxidase in hypoxia sensing and transduction in the carotid body (CB) chemoreceptor cells. We have studied the effects of several inhibitors of NADPH oxidase on the normoxic and hypoxia-induced release of [3H]catecholamines (CA) in an in vitro preparation of intact CB of the rat and rabbit whose CA deposits have been labeled by prior incubation with the natural precursor [3H]tyrosine. It was found that diphenyleneiodonium (DPI; 0.2-25 microM), an inhibitor of NADPH oxidase, caused a dose-dependent release of [3H]CA from normoxic CB chemoreceptor cells. Contrary to hypoxia, DPI-evoked release was only partially Ca2+ dependent. Concentrations of DPI reported to produce full inhibition of NADPH oxidase in the rat CB did not prevent the hypoxic release response in the rat and rabbit CB chemoreceptor cells, as stimulation with hypoxia in the presence of DPI elicited a response equaling the sum of that produced by DPI and hypoxia applied separately. Neopterin (3-300 microM) and phenylarsine oxide (0.5-2 microM), other inhibitors of NADPH oxidase, did not promote release of [3H]CA in normoxic conditions or affect the response elicited by hypoxia. On the basis of effects of neopterin and phenylarsine oxide, it is concluded that NADPH oxidase does not appear to play a role in oxygen sensing or transduction in the rat and rabbit CB chemoreceptor cells in vitro and, in the context of the present study, that DPI effects are not related to NADPH oxidase inhibition. (+info)Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. (3/1135)
Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide (As2O3) has been demonstrated to be an effective drug in the treatment of acute promyelocytic leukemia by inducing programmed cell death in leukemic cells both in vitro and in vivo. This prompted us to study the in vitro effects of As2O3 and of another arsenical derivative, the organic compound melarsoprol, on human myeloma cells and on the plasma cell differentiation of normal B cells. At pharmacological concentrations (10(-8) to 10(-6) mol/L), As2O3 and melarsoprol caused a dose- and time-dependent inhibition of survival and growth in myeloma cell lines that was, in some, similar to that of acute promyelocytic leukemia cells. Both arsenical compounds induced plasma cell apoptosis, as assessed by 4',6-diamidino-2-phenylindole staining, detection of phosphatidylserine at the cell surface using annexin V, and by the terminal deoxynucleotidyl transferase-mediated nick end labeling assay. As2O3 and melarsoprol also inhibited viability and growth and induced apoptosis in plasma-cell enriched preparations from the bone marrow or blood of myeloma patients. In nonseparated bone marrow samples, both arsenical compounds triggered death in myeloma cells while sparing most myeloid cells, as demonstrated by double staining with annexin V and CD38 or CD15 antibodies. In primary myeloma cells as in cell lines, interleukin 6 did not prevent arsenic-induced cell death or growth inhibition, and no synergistic effect was observed with IFN-alpha. In contrast to As2O3, melarsoprol only slightly reduced the plasma cell differentiation of normal B cells induced by pokeweed mitogen. Both pokeweed mitogen-induced normal plasma cells and malignant plasma cells showed a normal nuclear distribution of PML protein, which was disrupted by As2O3 but not by melarsoprol, suggesting that the two arsenical derivatives acted by different mechanisms. These results point to the use of arsenical derivatives as investigational drugs in the treatment of multiple myeloma. (+info)Interference in the quantitation of methylated arsenic species in human urine. (4/1135)
The aim of this paper is to report on the presence of chemical interferences in the quantitation of methylated arsenic species in human urine when using a method based on selective volatile arsine species generation, chromatographic separation, and hydride generation atomic absorption spectrometry (HGAAS) detection. An abnormal profile of methylated arsenic species characterized by the absence of the peak corresponding to dimethylarsinic acid (DMA) was observed in urine from some individuals exposed to arsenic via drinking water and living in rural communities of northwestern Argentina. The absence of this peak persisted even after the addition of known amounts of DMA to the samples. However, the DMA peak appeared after urine digestion with hydrochloric acid (2M). Samples showing interferences were provided by individuals who had mate consumption and coca-leaf chewing habits. Because the relative proportions of methylated arsenic species present in urine have been used to evaluate the efficiency of the methylation process, interferences in the formation or detection of methylarsines may cause underestimation of As exposure and also lead to erroneous conclusions about relative biomethylation efficiencies. Therefore, we recommend that urine samples should be digested with 2M HCl before performing speciation analysis using HGAA techniques. Further studies on the impact of this type of interferences on other arsenic speciation methods are also required. (+info)Phenylarsine oxide and ethanol prevent cell death of porcine polymorphonuclear leucocytes induced by phorbol myristate acetate. (5/1135)
In this study, we report that phenylarsine oxide and ethanol, both of which suppress a number of polymorphonuclear leucocyte functions including superoxide production, prevented the phorbol myristate acetate-induced cell death in a dose-dependent manner. These reagents had an inhibitory effect even after polymorphonuclear leucocytes were stimulated to produce superoxide by treatment with phorbol myristate acetate. The results indicate that activation of protein kinase C and subsequent superoxide release do not directly cause phorbol myristate acetate-induced cell death. Phenylarsine oxide or ethanol prevents cell death by affecting pathways downstream from those involved in the superoxide production. (+info)Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen. (6/1135)
In this report we have studied the role of phosphatidylinositol 3'-kinase (PI3-K) and tyrosine phosphatase activation on platelet activation by Convulxin (Cvx). Wortmannin, a specific PI3-K inhibitor, and phenylarsine oxide (PAO), a sulfhydryl reagent that inhibits tyrosine phosphatase (PTPase), block Cvx-induced platelet aggregation, granule secretion, inositol phosphate production, and increase in [Ca2+]i. However, PAO does not inhibit Cvx-induced tyrosine phosphorylation of platelet proteins, including Syk and PLCgamma2, but blocked collagen-induced platelet aggregation as well as tyrosine phosphorylation of PLCgamma2. In contrast, Cvx-induced PLCgamma2 tyrosyl phosphorylation was partially inhibited by wortmannin. We conclude that (i) although Cvx and collagen activate platelets by a similar mechanism, different regulatory processes are specific to each agonist; (ii) mechanisms other than tyrosine phosphorylation regulate PLCgamma2 activity; and (iii) besides protein tyrosine kinases, PI3-K (and PTPase) positively modulate platelet activation by both Cvx and collagen, and this enzyme is required for effective transmission of GPVI-Fc receptor gamma chain signal to result in full activation and tyrosine phosphorylation of PLCgamma2 in Cvx-stimulated platelets. (+info)Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (7/1135)
BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically achievable concentrations. METHODS: Eight malignant lymphocytic cell lines and primary cultures of lymphocytic leukemia and lymphoma cells were treated with As2O3, with or without dithiothreitol (DTT) or buthionine sulfoximine (BSO) (an inhibitor of glutathione synthesis). Apoptosis was assessed by cell morphology, flow cytometry, annexin V protein level, and terminal deoxynucleotidyl transferase labeling of DNA fragments. Cellular proliferation was determined by 5-bromo-2'-deoxyuridine incorporation into DNA and flow cytometry and by use of a mitotic arrest assay. Mitochondrial transmembrane potential (delta psi(m)) was measured by means of rhodamine 123 staining and flow cytometry. Protein expression was assessed by western blot analysis or immunofluorescence. RESULTS: Therapeutic concentrations of As2O3 (1-2 microM) had dual effects on malignant lymphocytes: 1) inhibition of growth through adenosine triphosphate (ATP) depletion and prolongation of cell cycle time and 2) induction of apoptosis. As2O3-induced apoptosis was preceded by delta psi(m) collapse. DTT antagonized and BSO enhanced As2O3-induced ATP depletion, delta psi(m) collapse, and apoptosis. Caspase-3 activation, usually resulting from delta psi(m) collapse, was not always associated with As2O3-induced apoptosis. As2O3 induced PML (promyelocytic leukemia) protein degradation but did not modulate expression of cell cycle-related proteins, including c-myc, retinoblastoma protein, cyclin-dependent kinase 4, cyclin D1, and p53, or expression of differentiation-related antigens. CONCLUSIONS: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 microM As2O3. As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders. (+info)Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. (8/1135)
Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury. In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited. H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2. Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2. Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation. Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3. Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus. These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway. (+info)Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells<...
Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as...
Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells | Molecular Cancer | Full Text
Phenylarsine oxide - Substance Information - ECHA
An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond.
Slots empire online casino - Pokerstars Summer Series : Becomingmrsseo
15. DPDK Release 18.05 - Data Plane Development Kit 21.11.0-rc0 documentation
Gentaur Molecular :Ato \ 100V 120V AC adapter for FLAT Viewer
\ 2196161
Gentaur Molecular :Ato \ EA 25 Column End Assembly
\ 1293622
Answered: Casual to Permanent affect jobseeker? - ATO Community
Answered: My employer claims it made mistaken super payment - ATO Community
Masuda Tomoyuki | TRIOS
Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines<...
Gallium Arsenide Market Overview, Scope And Chemical Research 2018 | Trade Calls
Arsenic trioxide: Its use in the treatment of acute promyelocytic leukemia<...
Arsenides Exporter, Manufacturer, Distributor, Supplier, Trading Company, Arsenides India
Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients With Acute Myeloid Leukemia - Tabular...
Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia
Study of Arsenic Trioxide in Small Cell Lung Cancer - Full Text View - ClinicalTrials.gov
Arsenic Trioxide - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
ARSENIC TRIOXIDE (ARSENITE)
Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...
Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive...
arsenic trioxide Intravenous - patient information, description, dosage and directions.
Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk...
Trisenox (Arsenic Trioxide Injection): Side Effects, Interactions, Warning, Dosage & Uses
Evaluation of Arsenic Trioxide Potential for Lung Cancer Treatment: ASSessment of Apoptotic Mechanisms and Oxidative Damage -...
Arsenic trioxide - An old drug re... preview & related info | Mendeley
PRIME PubMed | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined...
OBSERVATION OF DARK LINE DEGRADATION SITES IN ALUMINUM GALLIUM ARSENIDE GALLIUM ARSENIDE DH LASER MATERIAL BY ETCHING AND PHASE...
Arsenic trioxide in ovarian cancer | [email protected]
Arsenic trioxide in the mechanism of drug resistance reversal in MCF-7/ADM cell line of human breast cancer.
Figure 4 | Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung...
Clinical Trial | Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been...
Arsenic Trioxide - Manufacturer,Supplier,Exporter
Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans:...
Effective treatment for rare leukemia
Steady-State and Transient Electron Transport within Bulk InAs, InP and GaAs: An Updated Semiclassical Three-Valley Monte Carlo...
Radioprotection and Cell Cycle Arrest of Intestinal Epithelial Cells by Darinaparsin, a Tumor Radiosensitizer (Journal Article)...
Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for phase I clinical trial<...
ATRA-arsenic new standard of care for APL - PM360
Background Lung tumor is among the most lethal and common malignancies - HDAC Inhibition for the Disruption of Latent HIV-1...
Legal Notice | TRISENOX® (arsenic trioxide) injection
Arsenic Compounds Effective Against APL | Cancer Network | The Oncology Journal
Organometallic vapor-phase homoepitaxy of gallium arsenide assisted by a downstream hydrogen
The action of phenylarsine oxide on insulin stimulation of glucose transport in rat adipocytes | Biochemical Society...
Inorganic Arsenicals (Toxicity) - Toxicology - Merck Veterinary Manual
STRIPED GALLIUM ARSENIDE LASERS: MODE SIZE AND EFFICIENCY. - Nokia Bell Labs
Trisenox Side Effects in Detail - Drugs.com
Arsenic Trioxide in Treating Patients With Multiple Myeloma
Arsenic trioxide - toxicity, ecological toxicity and regulatory information
Background The tumor associated antigen (TAA) gp100 was one of the | Nutlin-3 overcomes arsenic trioxide resistance and tumor...
Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth | Oncotarget
Most recent papers with the keyword Journal of clinical oncology meta analysis | Read by QxMD
CAS No.1309-64-4,Diantimony trioxide Suppliers,MSDS download
Ecocentric | The Arsenic in Your Chicken
Arsenical
Arsenicals are chemical compounds that contain arsenic. In a military context, the term arsenical refer to toxic arsenic ... Look up arsenical in Wiktionary, the free dictionary. v t e (Arsenic compounds, Chemical weapons, Poisons, All stub articles, ... "Arsenicals - MeSH - NCBI". Handbook of chemical and biological warfare agents (2nd ed.). CRC Press. 24 August 2007. ISBN ...
Arsenical copper
Arsenical bronze Arsenical brass Rollason, EC (1949). Metallurgy for Engineers (2nd ed.). London: Arnold. "IBR - 1950 : Reg. ... Arsenical copper contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced ... Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. ...
Arsenical bronze
Arsenical copper Arsenical brass Charles, J. A. (January 1967). "Early Arsenical Bronzes - A Metallurgical view". American ... Arsenical bronze has seen little use in the modern period. It appears that the closest equivalent goes by the name of arsenical ... saw the use of arsenical bronze. Indeed, it seems that arsenical bronze was the most common alloy in use in the Mediterranean ... to be traded and used to make arsenical bronze elsewhere by addition to molten copper. Artifacts made of arsenical bronze cover ...
Arsenical keratosis
An arsenical keratosis is a growth of keratin on the skin caused by arsenic,: 725 which occurs naturally in the earth's crust ... Arsenical keratoses may persist indefinitely, and some may develop into invasive squamous cell carcinoma. Metastatic arsenic ... ISBN 0-7216-2921-0. Yerebakan O, Ermis O, Yilmaz E, Basaran E (February 2002). "Treatment of arsenical keratosis and Bowen's ... Topical 5-fluorouracil cream or 5% imiquimod cream may be useful in treating arsenical keratoses and Bowen's disease. Freedberg ...
Arsenic
"organic arsenicals". EPA. "Trace Elements in Soils and Plants, Third Edition". CRC Press. Archived from the original on 21 ... However, arsenicals such as melarsoprol are still used for the treatment of trypanosomiasis, since although these drugs have ... These organic arsenicals were in turn phased out by 2013 in all agricultural activities except cotton farming. The ... "Phosphorus Deoxidized Arsenical Copper" with an arsenic content of 0.3% has an increased corrosion stability in certain ...
Lead hydrogen arsenate
Inorganic Arsenicals; Intent to Cancel Registrations for Pesticide Products Registered for Non-Wood Preservative Use; ... Herrick, Glenn Washington (1910). "The Snow-white Linden Moth". Historic Arsenical Pesticide Research (PDF) (Report). US ... Lead arsenate was the most extensively used arsenical insecticide. Two principal formulations of lead arsenate were marketed: ...
Arsine
Suchard, Jeffrey R. (March 2006). "CBRNE - Arsenicals, Arsine". EMedicine. Archived from the original on 2006-06-23. Retrieved ...
Colin Raston
... the arsenical constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in metabolism of arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Högberg, A. G. S. ( ...
Arsenobetaine
... the Arsenical Constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in Metabolism of Arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Ng, J. C. (2005). " ...
November 1900
"Arsenical Beer". The Times. London. February 13, 1901. p. 9. "Twelve-Inch Gun a Wonder". The New York Times. November 16, 1900 ...
Cacodyl cyanide
Organic Arsenical Compounds. 1923. "Scientific Worthies" (PDF). 28 April 1881. Archived (PDF) from the original on 2021-12-12. ... Seyferth D (2001). "Cadet's Fuming Arsenical Liquid and the Cacodyl Compounds of Bunsen". Organometallics. 20 (8): 1488-1498. ...
Otto Neubauer
Neubauer, O (1947). "Arsenical Cancer: A Review". British Journal of Cancer. 1 (2): 192-251. doi:10.1038/bjc.1947.22. ISSN 0007 ...
Arsenic biochemistry
Lin, Lin S.; Thomas, D. J.; Cullen, W. R.; Wang, C.; Styblo, M.; Del Razo, L. M. (2001). "Arsenicals inhibit thioredoxin ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ... Kitchin, K.T; Wallace, K (2008). "Evidence against the nuclear in situ binding of arsenicals-Oxidative stress theory of arsenic ... Nesnow, S; Roop, B.C (2002). "DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species". ...
P-Azobenzenearsonate
... is an arsenical. It causes antibody formation and delayed hypersensitivity when bound to aromatic amino ...
Karasuk culture
Arsenical bronze artefacts are present. Their settlements were of pit houses and they buried their dead in stone cists covered ...
Leeds City Museum
Chestofbooks.com webpage: Arsenical soap. Chrystal, Paul (2016). Leeds in 50 Buildings: 9. Leeds City Museum 1819 Park Row. ... as the Victorians will have preserved it with arsenical soap. For over a century it has sagged somewhat, as can be seen in the ...
Imperial Oil (Superfund site)
One, which reprocessed waste oil, may have discharged wastes to a nearby stream; another company produced arsenical pesticides ...
Georges-Simon Serullas
Antimoine arsenical dans le commerce. Metz, Antoine, September 1820. Second mémoire sur les alliages du potassium et sur ...
Monosodium methyl arsonate
"Organic Arsenical Products Task Force". National Library of Medicine. "Sodium Methanearsonate". HSDB Database. Specific ...
Potassium arsenite
ISBN 0-8493-0474-1. Jolliffe, D. M. (1993). "The history of the use of arsenicals in man". Journal of the Royal Society of ...
Methyldichloroarsine
Fitzgerald GM, Vollmer T (2006-06-19). "CBRNE - Vesicants, Organic Arsenicals: L, ED, MD, PD, HL". WebMD. Retrieved 2008-12-23 ... Arsenical vesicants, Organoarsenic chlorides, World War I chemical weapons, Arsenic(III) compounds). ...
Phenyldichloroarsine
... is an arsenical vesicant which can be mixed with mustard agents for use in chemical warfare. PD was ... Phenyldichloroarsine, also known by its wartime name phenyl Dick and its NATO abbreviation PD, is an organic arsenical vesicant ... Fitzgerald GM, Vollmer T (19 June 2006). "CBRNE - Vesicants, Organic Arsenicals: L, ED, MD, PD, HL". emedicine. WebMD. ... Phenyldichloroarsine is one of four organic arsenicals, the other three are lewisite (L), methyldichloroarsine (MD), and ...
Arsanilic acid
Since at least 2000 BC, arsenic and inorganic arsenical compounds were both medicine and poison. In the 19th century, inorganic ... In the late 1940s, Salvarsan was replaced in most regions by penicillin, yet organic arsenicals remained in use for ... For poultry and swine, arsanilic acid was among four arsenical veterinary drugs, along with carbarsone, nitarsone, roxarsone, ... the first organic arsenical drug. In 1905, in Britain, H W Thomas and A Breinl reported successful treatment of trypanosomiasis ...
List of patent medicines
Fowler's solution: an arsenical compound sold in the 19th century for various ailments including treatment of leukemia. ... Jolliffe, D. M. (1993). "A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289 ...
Arsenite
"A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007. PMID ...
Fowler's solution
From 1905, inorganic arsenicals like Fowler's solution saw diminished use as attention turned to organic arsenicals, starting ... As arsenical compounds are notably toxic and carcinogenic-with side effects such as cirrhosis of the liver, idiopathic portal ... "A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289. doi:10.1177/ ...
Hal Dixon (biochemist)
Webster, D.; Sparkes, M. J.; Dixon, H B F. (1978). "An arsenical analogue of adenosine diphosphate". Biochemical Journal. 169 ( ...
Black Widows of Liverpool
An Arsenical Solution of Fly Papers.- Unexampled Cruelty". Vol. I, no. 16. Te Aroha News. 19 April 1884. p. 5. Retrieved 7 May ...
Realgar
Jie Liu; Yuanfu Lu; Qin Wu; Robert A. Goyer; Michael P. Waalkes (August 2008). "Mineral arsenicals in traditional medicines: ...
Toroku arsenic disease
"Chronic arsenical poisoning due to environmental pollution. Seven cases among inhabitants near an abandoned mine." (1976). ...
Browsing by Subject "Arsenicals"
Gomez-Caminero, A; Howe, Paul D; Hughes, M; Kenyon, E; Lewis, D. R; Moore, M; Aitio, A; Becking, George C; Ng, J; International Programme on Chemical Safety; WHO Task Group on Environmental Health Criteria for Arsenic and Arsenic Compounds (World Health OrganizationWorld Health Organization, 2001) ...
CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Clinical Presentation: History, Physical Examination
The 4 organic arsenicals are lewisite (L), methyldichloroarsine (MD), phenyldichloroarsine (PD), and ethyldichloroarsine (ED). ... Organic arsenicals cause immediate signs, whereas signs of mustard exposure appear after a latent period of several hours. ... CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Clinical Presentation. Updated: Mar 30, 2022 ... Physical signs of organic arsenical exposure are similar to those of mustard agents. The major difference is the time of onset ...
RCSB PDB - 3F6V: Crystal structure of Possible transcriptional regulator for arsenical resistance
Crystal structure of Possible transcriptional regulator for arsenical resistance ... Crystal structure of Possible transcriptional regulator for arsenical resistance from Rhodococcus sp.. Chang, C., Xu, X., Zheng ... Crystal structure of Possible transcriptional regulator for arsenical resistance. *PDB DOI: 10.2210/pdb3F6V/pdb ...
NIOSHTIC-2 Publications Search - 10005109 - Calcium Chloride-oxygen Leaching and Metals Recovery from an Arsenical Copper...
A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by ... A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by ... Calcium Chloride-oxygen Leaching and Metals Recovery from an Arsenical Copper-cobalt Concentrate.. ...
Bulletin: Number 695: Non-Arsenical Dusts for Cauliflower and Cabbage Worm Control on Long Island
Differential activation of AP‐1 in human bladder epithelial cells by inorganic and methylated arsenicals
Results of search for 'su:{Arsenicals}' › WHO HQ Library catalog
Arsenic and arsenic compounds. by Gomez-Caminero, A , Howe, Paul D , Hughes, M , Kenyon, E , Lewis, D. R , Moore, M , Aitio, A , Becking, George C , Ng, J , International Programme on Chemical Safety , WHO Task Group on Environmental Health Criteria for Arsenic and Arsenic Compounds.. Series: Environmental health criteria ; 224Material type: ...
Insects in the City: Arsenical Herbicides on Way Out
This week the U.S. EPA announced that all registrations of the organic arsenical herbicides, including the popular Dallisgrass ... The decision comes as a result of a 2006 Reregistration Eligibility Decision (RED) that concluded that the arsenical herbicides ... arsenicals_fs.html. Dallisgrass is the real problem weed for southern turfgrass, for which there are still no good alternatives ...
CDC - Immediately Dangerous to Life or Health Concentrations (IDLH): Hydrogen cyanide - NIOSH Publications and Products
WBC count: MedlinePlus Medical Encyclopedia
Arsenical Bronze - an Alloy - QS Study
Arsenical bronze is a bronze alloy in which arsenic is added to copper instead of or in addition to tin or other component ... Health effects of arsenical bronze use. Arsenic has a vaporization point of 615 °C, therefore arsenical oxide will be lost from ... Modern uses of arsenical bronze. In the present era, arsenical bronze has found minimal use. The closest counterpart appears to ... Arsenical bronze is a bronze alloy in which arsenic is added to copper instead of or in addition to tin or other component ...
CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Treatment & Management: Prehospital Care, Emergency Department Care,...
The 4 organic arsenicals are lewisite (L), methyldichloroarsine (MD), phenyldichloroarsine (PD), and ethyldichloroarsine (ED). ... CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Treatment & Management. Updated: Mar 30, 2022 ... encoded search term (CBRNE - Vesicants%2C Organic Arsenicals - L%2C ED%2C MD%2C PD%2C HL) and CBRNE - Vesicants, Organic ... The arsenicals. Military Chemical and Biological Agents: Chemical and Toxicological Properties. 1987. 17-43. ...
Browsing by Subject
Arsenic Toxicity: Where is Arsenic Found? | Environmental Medicine | ATSDR
Component Uses of Arsenicals. Discontinued arsenic-containing pesticides may still be found in some U.S. farms and homes [ATSDR ... Use of arsenicals in chemical warfare.. *Chlorovinyl dichloroarsine (also known as lewisite) was developed as a chemical ... Wood treated with CCA is known as "pressure treated wood". In response to consumer concerns, U.S. manufacturers of arsenical ... Arsine gas, the most toxic arsenical (acute exposures), is used commercially in the microelectronics industry, and it is ...
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells | UBC Chemistry
Trivalent dimethylated arsenicals were at least as cytotoxic as trivalent iAs (arsenite) for most cell types. Pentavalent ... Among the arsenicals examined, trivalent monomethylated species were the most cytotoxic in all cell types. ... Pentavalent mono- and dimethylated arsenicals are less acutely toxic than iAs. However, little is known about the toxicity of ... In the work reported here the toxicities of iAs and trivalent and pentavalent methylated arsenicals were examined in cultured ...
Injuries Among Survivors of the Terrorist Attack
CDC | Case Definition: Inorganic Arsenic Poisoning
Localized alveolar bone necrosis following the use of an arsenical paste: a case report | AVESİS
Advanced Search Results - Public Health Image Library(PHIL)
Arsenic | Medical Management Guidelines | Toxic Substance Portal | ATSDR
Washing arsenical residues from the skin or eyes usually reduces the irritant effect. If arsenic trioxide is swallowed, ... Arsenicals can react violently with strong oxidizing materials and active metals (HSDB 2007; NIOSH 2005). Hydrogen gas can ... Hepatocellular injury after acute exposure to inorganic arsenicals is uncommon, but fatty infiltration of the liver, central ...
WBC count
Award Information | HHS TAGGS
Plant and Chemical Poisonings | Iowa State University
Phenylarsonic (Organic Arsenical) Poisoning. Roxarsone and arsanilic acid are used to promote growth and to treat swine ... Prevention of organic arsenical poisoning can be achieved simply by correct management of these legal compounds during feed ... Blindness is not typical of poisoning with other organic arsenicals. Paralyzed pigs remain alert. If provided with feed and ...
Signs and Symptoms of Pesticide Poisoning
Arsenical Herbicides. Examples include Ansar and Montar. Acute arsenic poisoning usually appears within one hour of ingestion. ... Arsenical wood preservatives (chromated copper arsenate [CCA] and ammoniacal copper arsenate [ACA]) can cause nausea, headache ... Prolonged exposure to arsenical wood preservatives can result in persistent headache, abdominal distress, salivation, low grade ...
Search Results: Ankle - skin of, Rash or multiple lesions
Nutritional deficiency and arsenical manifestations: A perspective study in an arsenic-endemic region of West Bengal, India -...
Increased risk of arsenical skin lesions was found for those in the lowest quintile of protein intake (v. highest quintile: OR ... Nutritional deficiency and arsenical manifestations: A perspective study in an arsenic-endemic region of West Bengal, India. D ... View more info for Nutritional deficiency and arsenical manifestations: a perspective study in an arsenic-endemic region of ... are found to be associated with arsenical skin lesions in West Bengal. Copyright © The Authors 2012. ...
NIOSHTIC-2 Search Results - Full View
Heartworm Disease in Dogs, Cats, and Ferrets - Circulatory System - MSD Veterinary Manual
Non-arsenical (Macrolide + Doxycycline) Adulticidal Therapy Cases in which non-arsenical adulticidal therapy might be ... Arsenical (Melarsomine) Adulticidal Therapy The only approved heartworm adulticide is melarsomine dihydrochloride, which is ... Non-arsenical protocols using ivermectin can be used in cases of melarsomine failure or significant financial constraints ... non-arsenical adulticide: preventive dosage ivermectin or moxidectin (twice a month for 6 months) + doxycycline, exercise ...
Daus, Dr. Birgit - Helmholtz-Centre for Environmental Research
Raised with arsenical drugs1
- The newly published CLF study is the first to quantify concentrations of specific forms of arsenic (most notably inorganic arsenic) within chicken meat, and the first to directly compare arsenic concentrations in meat samples from birds likely raised with arsenical drugs to samples from chickens raised without these drugs. (civileats.com)
Trivalent methylated arsenicals1
- These results suggest that (1) trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and (2) high methylation capacity does not protect cells from the acute toxicity of trivalent arsenicals. (ubc.ca)
Arsenic8
- A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by the Bureau of Mines as an alternative to smelting, which is no longer considered an environmentally acceptable method for treating arsenic- containing ores. (cdc.gov)
- Arsenical bronze is a bronze alloy in which arsenic is added to copper instead of or in addition to tin or other component metals. (qsstudy.com)
- Because copper ore is frequently naturally contaminated with arsenic, the term "arsenical bronze" is normally applied exclusively to alloys having an arsenic level greater than 1% by weight, in order to separate it from possible accidental arsenic additions. (qsstudy.com)
- Arsenical bronze daggers from the Caucasus and other artifacts from various locales have an arsenic-rich surface layer that may have been intentionally manufactured by ancient craftsmen, and Mexican bells were made of copper with enough arsenic to color them silver. (qsstudy.com)
- Arsenic has a vaporization point of 615 °C, therefore arsenical oxide will be lost from the melt before or during casting, and fumes from mining and ore processing fires have long been recognized to harm the nervous system, eyes, lungs, and skin. (qsstudy.com)
- Turns out that when you feed arsenical drugs to livestock, the arsenic doesn't just magically disappear. (civileats.com)
- 70 percent of samples from conventional producers without policies prohibiting arsenical use had inorganic arsenic levels that exceeded the aforementioned FDA safety standard. (civileats.com)
- Researchers found that the resulting transgenic plant acquired the potential for methylating inorganic arsenic to a variety of harmless organic species, including volatile arsenicals. (org.in)
Organic8
- Physical signs of organic arsenical exposure are similar to those of mustard agents. (medscape.com)
- Organic arsenicals cause immediate signs, whereas signs of mustard exposure appear after a latent period of several hours. (medscape.com)
- This week the U.S. EPA announced that all registrations of the organic arsenical herbicides, including the popular Dallisgrass killer, MSMA would begin being phased out. (blogspot.com)
- however, organic arsenicals attack rubber and can cause it to break down with prolonged exposure. (medscape.com)
- Victims of severe toxicity from an organic arsenical may require prolonged care for dermatologic, ophthalmic, and pulmonary sequelae. (medscape.com)
- Blindness is not typical of poisoning with other organic arsenicals. (iastate.edu)
- Prevention of organic arsenical poisoning can be achieved simply by correct management of these legal compounds during feed preparation or medication. (iastate.edu)
- The researchers tested samples of three types of chicken breast: organic (which means the meat came from birds that were required to be raised without arsenical drugs), antibiotic-free (which means the birds were raised without antibiotics, but not necessarily without arsenicals) and conventional (which, given the high rate of arsenical use when the study was conducted between December 2010 and June 2011, means the birds likely received arsenical drugs). (civileats.com)
Inorganic1
- Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). (ubc.ca)
Toxicity1
- To characterize the role of methylation in the protection against toxicity of arsenicals, the capacities of cells to produce methylated metabolites were also examined. (ubc.ca)
Roxarsone1
- Moreover, Pfizer still sells nitarsone, another arsenical drug similar to roxarsone. (civileats.com)
West Bengal2
- IMSEAR at SEARO: Arsenical dermatosis from tubewell water in West Bengal. (who.int)
- Conclusions Deficiencies of Zn, Mg and Cu, in addition to protein, B vitamins and choline, are found to be associated with arsenical skin lesions in West Bengal. (caluniv.ac.in)
Copper2
- Calcium Chloride-oxygen Leaching and Metals Recovery from an Arsenical Copper-cobalt Concentrate. (cdc.gov)
- The closest counterpart appears to be arsenical copper, defined as copper with less than 0.5 wt percent As, which is below the accepted level in archaeological artifacts. (qsstudy.com)
Bronze1
- In the present era, arsenical bronze has found minimal use. (qsstudy.com)
Peripheral1
- Peripheral neuropathy caused by arsenical intoxication. (cdc.gov)
Paste1
- bakeries, where children slowly roast before the ovens," "binderies, paper-box and paint factories, where arsenical paper, rotting paste, and the poison of the paints are injurious. (slate.com)
Acid1
- Topical delivery of nordihydroguaretic acid for attenuating cutaneous damage caused by arsenicals. (medscape.com)
Species1
- Among the arsenicals examined, trivalent monomethylated species were the most cytotoxic in all cell types. (ubc.ca)
Toxic2
- Pentavalent mono- and dimethylated arsenicals are less acutely toxic than iAs. (ubc.ca)
- Arsenicals are known for producing toxic effects in humans, if not processed as per classical text therefore, the present study was aim to generate data for the safety of RM in albino rats. (journaltocs.ac.uk)
Poultry1
- The researchers also contacted the various poultry producers to determine whether they had established policies to prohibit arsenical use, and divided the samples accordingly. (civileats.com)
Study1
- Today, researchers at the Johns Hopkins Center for a Livable Future published a study in the scientific journal Environmental Health Perspectives that provided further evidence of the risks associated with the use of arsenicals in animal agriculture. (civileats.com)
Protect cells1
- Do Superoxide Dismutase and Catalase Protect Cells from DNA Damage Induced by Active Arsenicals? (researchgate.net)
Drugs1
- The drug caused healing of local lesions in all five cases that was comparable to the favorable effect usually obtained with arsenical drugs. (ajtmh.org)
Found1
- They found enough to satisfy then that he died from arsenical poisoning. (vermontcivilwar.org)
Article1
- Cet article se propose de décrire de façon succincte la chaîne de production kuro-araxe dans son entièreté, en commençant par l'extraction et la préparation du minerai, sa mise en poudre et enfin l'opération de réduction. (openedition.org)
Promote growth1
- Back in the 1940s, producers started using arsenicals to promote growth, treat disease and improve meat pigmentation. (civileats.com)
Skin1
- In the work reported here the toxicities of iAs and trivalent and pentavalent methylated arsenicals were examined in cultured human cells derived from tissues that are considered a major site for iAs methylation (liver) or targets for carcinogenic effects associated with exposure to iAs (skin, urinary bladder, and lung). (ubc.ca)
Agents1
- Li C, Srivastava RK, Athar M. Biological and environmental hazards associated with exposure to chemical warfare agents: arsenicals. (medscape.com)
Effect1
- Arsenicals had limited effect on the pest, so there was little to prevent its rapid spread through the orange and lemon groves of California in the 1880's. (wikisummaries.org)
Types1
- Trivalent dimethylated arsenicals were at least as cytotoxic as trivalent iAs (arsenite) for most cell types. (ubc.ca)