Arsenicals. Medical search

Inorganic or organic compounds that contain arsenic.

A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)

Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)

An arsenical that has been used as a dermatologic agent and as an herbicide.

Inorganic salts or organic esters of arsenious acid.

Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.

A general class of integral membrane proteins that transport ions across a membrane against an electrochemical gradient.

Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions.

A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.

Inorganic or organic salts and esters of arsenic acid.

An arsenic derivative which has anticoccidial action and promotes growth in animals.

Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.

An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.

An effective trypanocidal agent.

Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.

Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.

A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.

A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)

Inorganic compounds that contain sodium as an integral part of the molecule.

Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.

Water that is intended to be ingested.

Proteins involved in the transport of NUCLEOSIDES across cellular membranes.

Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)

A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.

A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.

A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).

The epithelial lining of the URINARY TRACT.

A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.

A species of monogenetic, parasitic protozoa usually found in insects.

A genus of flagellate protozoans found in the blood and lymph of vertebrates and invertebrates, both hosts being required to complete the life cycle.

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

Spectrophotometric techniques by which the absorption or emmision spectra of radiation from atoms are produced and analyzed.

A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.

Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.

Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.

Compounds containing the -SH radical.

In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.

Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.

A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.

Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.

A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.

A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.

The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.

Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.

The rate dynamics in chemical or physical systems.

The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (1/1135)

Primary blasts of a t(11;17)(q23;q21) acute promyelocytic leukaemia (APL) patient were analysed with respect to retinoic acid (RA) and arsenic trioxide (As2O3) sensitivity as well as PLZF/RARalpha status. Although RA induced partial monocytic differentiation ex vivo, but not in vivo, As203 failed to induce apoptosis in culture, contrasting with t(15;17) APL and arguing against the clinical use of As203 in t(11;17)(q23;q21) APL. Prior to cell culture, PLZF/RARalpha was found to exactly co-localize with PML onto PML nuclear bodies. However upon cell culture, it quickly shifted towards microspeckles, its localization found in transfection experiments. Arsenic trioxide, known to induce aggregation of PML nuclear bodies, left the microspeckled PLZF/RARalpha localization completely unaffected. RA treatment led to PLZF/RARalpha degradation. However, this complete PLZF/RARalpha degradation was not accompanied by differentiation or apoptosis, which could suggest a contribution of the reciprocal RARalpha/PLZF fusion product in leukaemogenesis or the existence of irreversible changes induced by the chimera. (+info)

NADPH oxidase inhibition does not interfere with low PO2 transduction in rat and rabbit CB chemoreceptor cells. (2/1135)

The aim of the present work was to elucidate the role of NADPH oxidase in hypoxia sensing and transduction in the carotid body (CB) chemoreceptor cells. We have studied the effects of several inhibitors of NADPH oxidase on the normoxic and hypoxia-induced release of [3H]catecholamines (CA) in an in vitro preparation of intact CB of the rat and rabbit whose CA deposits have been labeled by prior incubation with the natural precursor [3H]tyrosine. It was found that diphenyleneiodonium (DPI; 0.2-25 microM), an inhibitor of NADPH oxidase, caused a dose-dependent release of [3H]CA from normoxic CB chemoreceptor cells. Contrary to hypoxia, DPI-evoked release was only partially Ca2+ dependent. Concentrations of DPI reported to produce full inhibition of NADPH oxidase in the rat CB did not prevent the hypoxic release response in the rat and rabbit CB chemoreceptor cells, as stimulation with hypoxia in the presence of DPI elicited a response equaling the sum of that produced by DPI and hypoxia applied separately. Neopterin (3-300 microM) and phenylarsine oxide (0.5-2 microM), other inhibitors of NADPH oxidase, did not promote release of [3H]CA in normoxic conditions or affect the response elicited by hypoxia. On the basis of effects of neopterin and phenylarsine oxide, it is concluded that NADPH oxidase does not appear to play a role in oxygen sensing or transduction in the rat and rabbit CB chemoreceptor cells in vitro and, in the context of the present study, that DPI effects are not related to NADPH oxidase inhibition. (+info)

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. (3/1135)

Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide (As2O3) has been demonstrated to be an effective drug in the treatment of acute promyelocytic leukemia by inducing programmed cell death in leukemic cells both in vitro and in vivo. This prompted us to study the in vitro effects of As2O3 and of another arsenical derivative, the organic compound melarsoprol, on human myeloma cells and on the plasma cell differentiation of normal B cells. At pharmacological concentrations (10(-8) to 10(-6) mol/L), As2O3 and melarsoprol caused a dose- and time-dependent inhibition of survival and growth in myeloma cell lines that was, in some, similar to that of acute promyelocytic leukemia cells. Both arsenical compounds induced plasma cell apoptosis, as assessed by 4',6-diamidino-2-phenylindole staining, detection of phosphatidylserine at the cell surface using annexin V, and by the terminal deoxynucleotidyl transferase-mediated nick end labeling assay. As2O3 and melarsoprol also inhibited viability and growth and induced apoptosis in plasma-cell enriched preparations from the bone marrow or blood of myeloma patients. In nonseparated bone marrow samples, both arsenical compounds triggered death in myeloma cells while sparing most myeloid cells, as demonstrated by double staining with annexin V and CD38 or CD15 antibodies. In primary myeloma cells as in cell lines, interleukin 6 did not prevent arsenic-induced cell death or growth inhibition, and no synergistic effect was observed with IFN-alpha. In contrast to As2O3, melarsoprol only slightly reduced the plasma cell differentiation of normal B cells induced by pokeweed mitogen. Both pokeweed mitogen-induced normal plasma cells and malignant plasma cells showed a normal nuclear distribution of PML protein, which was disrupted by As2O3 but not by melarsoprol, suggesting that the two arsenical derivatives acted by different mechanisms. These results point to the use of arsenical derivatives as investigational drugs in the treatment of multiple myeloma. (+info)

Interference in the quantitation of methylated arsenic species in human urine. (4/1135)

The aim of this paper is to report on the presence of chemical interferences in the quantitation of methylated arsenic species in human urine when using a method based on selective volatile arsine species generation, chromatographic separation, and hydride generation atomic absorption spectrometry (HGAAS) detection. An abnormal profile of methylated arsenic species characterized by the absence of the peak corresponding to dimethylarsinic acid (DMA) was observed in urine from some individuals exposed to arsenic via drinking water and living in rural communities of northwestern Argentina. The absence of this peak persisted even after the addition of known amounts of DMA to the samples. However, the DMA peak appeared after urine digestion with hydrochloric acid (2M). Samples showing interferences were provided by individuals who had mate consumption and coca-leaf chewing habits. Because the relative proportions of methylated arsenic species present in urine have been used to evaluate the efficiency of the methylation process, interferences in the formation or detection of methylarsines may cause underestimation of As exposure and also lead to erroneous conclusions about relative biomethylation efficiencies. Therefore, we recommend that urine samples should be digested with 2M HCl before performing speciation analysis using HGAA techniques. Further studies on the impact of this type of interferences on other arsenic speciation methods are also required. (+info)

Phenylarsine oxide and ethanol prevent cell death of porcine polymorphonuclear leucocytes induced by phorbol myristate acetate. (5/1135)

In this study, we report that phenylarsine oxide and ethanol, both of which suppress a number of polymorphonuclear leucocyte functions including superoxide production, prevented the phorbol myristate acetate-induced cell death in a dose-dependent manner. These reagents had an inhibitory effect even after polymorphonuclear leucocytes were stimulated to produce superoxide by treatment with phorbol myristate acetate. The results indicate that activation of protein kinase C and subsequent superoxide release do not directly cause phorbol myristate acetate-induced cell death. Phenylarsine oxide or ethanol prevents cell death by affecting pathways downstream from those involved in the superoxide production. (+info)

Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen. (6/1135)

In this report we have studied the role of phosphatidylinositol 3'-kinase (PI3-K) and tyrosine phosphatase activation on platelet activation by Convulxin (Cvx). Wortmannin, a specific PI3-K inhibitor, and phenylarsine oxide (PAO), a sulfhydryl reagent that inhibits tyrosine phosphatase (PTPase), block Cvx-induced platelet aggregation, granule secretion, inositol phosphate production, and increase in [Ca2+]i. However, PAO does not inhibit Cvx-induced tyrosine phosphorylation of platelet proteins, including Syk and PLCgamma2, but blocked collagen-induced platelet aggregation as well as tyrosine phosphorylation of PLCgamma2. In contrast, Cvx-induced PLCgamma2 tyrosyl phosphorylation was partially inhibited by wortmannin. We conclude that (i) although Cvx and collagen activate platelets by a similar mechanism, different regulatory processes are specific to each agonist; (ii) mechanisms other than tyrosine phosphorylation regulate PLCgamma2 activity; and (iii) besides protein tyrosine kinases, PI3-K (and PTPase) positively modulate platelet activation by both Cvx and collagen, and this enzyme is required for effective transmission of GPVI-Fc receptor gamma chain signal to result in full activation and tyrosine phosphorylation of PLCgamma2 in Cvx-stimulated platelets. (+info)

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (7/1135)

BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically achievable concentrations. METHODS: Eight malignant lymphocytic cell lines and primary cultures of lymphocytic leukemia and lymphoma cells were treated with As2O3, with or without dithiothreitol (DTT) or buthionine sulfoximine (BSO) (an inhibitor of glutathione synthesis). Apoptosis was assessed by cell morphology, flow cytometry, annexin V protein level, and terminal deoxynucleotidyl transferase labeling of DNA fragments. Cellular proliferation was determined by 5-bromo-2'-deoxyuridine incorporation into DNA and flow cytometry and by use of a mitotic arrest assay. Mitochondrial transmembrane potential (delta psi(m)) was measured by means of rhodamine 123 staining and flow cytometry. Protein expression was assessed by western blot analysis or immunofluorescence. RESULTS: Therapeutic concentrations of As2O3 (1-2 microM) had dual effects on malignant lymphocytes: 1) inhibition of growth through adenosine triphosphate (ATP) depletion and prolongation of cell cycle time and 2) induction of apoptosis. As2O3-induced apoptosis was preceded by delta psi(m) collapse. DTT antagonized and BSO enhanced As2O3-induced ATP depletion, delta psi(m) collapse, and apoptosis. Caspase-3 activation, usually resulting from delta psi(m) collapse, was not always associated with As2O3-induced apoptosis. As2O3 induced PML (promyelocytic leukemia) protein degradation but did not modulate expression of cell cycle-related proteins, including c-myc, retinoblastoma protein, cyclin-dependent kinase 4, cyclin D1, and p53, or expression of differentiation-related antigens. CONCLUSIONS: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 microM As2O3. As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders. (+info)

Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. (8/1135)

Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury. In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited. H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2. Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2. Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation. Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3. Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus. These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway. (+info)

Research on arsenical dye[edit]. Ehrlich joined the Institute of Experimental Therapy (Institut für experimentelle Therapie) at ... Here his research focused on testing arsenical dyes for killing microbes. Arsenic was an infamous poison, and his attempt was ...

https://en.wikipedia.org/wiki/Magic_bullet_

Suchard, Jeffrey R. (March 2006). "CBRNE - Arsenicals, Arsine". EMedicine. Retrieved 2006-09-05. Marsh, James (1836). "Account ...

https://en.wikipedia.org/wiki/Arsine

... the arsenical constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in metabolism of arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Högberg, A. G. S. ( ...

https://en.wikipedia.org/wiki/Colin_Raston

... the Arsenical Constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in Metabolism of Arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Ng, J. C. (2005). " ...

https://en.wikipedia.org/wiki/Arsenobetaine

ISBN 0-7817-2845-2. Gebel TW (March 2001). "Genotoxicity of arsenical compounds". International Journal of Hygiene and ... "Inhibition of insulin-dependent glucose uptake by trivalent arsenicals: possible mechanism of arsenic-induced diabetes". ...

https://en.wikipedia.org/wiki/Arsenic_poisoning

Lin, Lin S.; Thomas, D. J.; Cullen, W. R.; Wang, C.; Styblo, M.; Del Razo, L. M. (2001). "Arsenicals inhibit thioredoxin ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ... Kitchin, K.T; Wallace, K (2008). "Evidence against the nuclear in situ binding of arsenicals-Oxidative stress theory of arsenic ... Nesnow, S; Roop, B.C (2002). "DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species". ...

https://en.wikipedia.org/wiki/Arsenic_biochemistry

... is an arsenical. It causes antibody formation and delayed hypersensitivity when bound to aromatic amino ...

https://en.wikipedia.org/wiki/P-Azobenzenearsonate

Arsenical bronze artefacts are present. Their settlements were of pit houses and they buried their dead in stone cists covered ...

https://en.wikipedia.org/wiki/Karasuk_culture

However the pelt may now be dangerous after all, in a sense, as the Victorians may have preserved it with arsenical soap. ... Chestofbooks.com webpage: Arsenical soap. Information received 10 March 2009 verbally from museum curator. 24dash.com: Sting in ...

https://en.wikipedia.org/wiki/Leeds_City_Museum

One, which reprocessed waste oil, may have discharged wastes to a nearby stream; another company produced arsenical pesticides ...

https://en.wikipedia.org/wiki/Imperial_Oil_(Superfund_site)

"Organic Arsenical Products Task Force". National Library of Medicine. "Sodium Methanearsonate". HSDB Database. ...

https://en.wikipedia.org/wiki/Monosodium_methyl_arsonate

ISBN 0-8493-0474-1. DM, J. (1993). "The History of the use of Arsenicals in Man". Journal of the Royal Society of Medicine. 86 ...

https://en.wikipedia.org/wiki/Potassium_arsenite

Organic Arsenicals: L, ED, MD, PD, HL". WebMD. Retrieved 2008-12-23. Ledgard, J. (2006). The Laboratory History of Chemical ...

https://en.wikipedia.org/wiki/Methyldichloroarsine

CS1 maint: Uses authors parameter (link) Jolliffe DM (1993). "A history of the use of arsenicals in man". Journal of the Royal ... Since at least 2000 BC, arsenic and inorganic arsenical compounds were both medicine and poison. In the 19th century, inorganic ... In the late 1940s, Salvarsan was replaced in most regions by penicillin, yet organic arsenicals remained in use for ... For poultry and swine, arsanilic acid was among four arsenical veterinary drugs, along with carbarsone, nitarsone, roxarsone, ...

https://en.wikipedia.org/wiki/Arsanilic_acid

An Arsenical Solution of Fly Papers.- Unexampled Cruelty". Volume I, Issue 16. Te Aroha News. 19 April 1884. p. 5. Retrieved 7 ...

https://en.wikipedia.org/wiki/Black_Widows_of_Liverpool

Toxicity of trivalent arsenicalsEdit. Enzymes and receptors that contain thiol or sulfhydryl functional groups are actively ... Toxicity of pentavalent arsenicalsEdit. Due to its similar structure and properties, pentavalent arsenic metabolites are ... Ebert, F; Weiss, A (2011). "Arsenicals affect base excision repair by several mechanisms". Mutat. Res. 715 (1-2): 32-41. doi: ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ...

https://en.m.wikipedia.org/wiki/Arsenic_biochemistry

Arsenicals[edit]. *Ethyldichloroarsine (ED). *Methyldichloroarsine (MD). *Phenyldichloroarsine (PD). *2- ...

https://en.wikipedia.org/wiki/List_of_chemical_warfare_agents

Arsenical brass. Arsenic; frequently aluminum. Used for boiler fireboxes. Cartridge brass (C260). 70. 30. -. ≤ 0.07[29]. Good ...

https://en.wikipedia.org/wiki/Brassware

"A history of the use of arsenicals in man" (pdf). Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007 . PMID ...

https://en.wikipedia.org/wiki/Arsenite

At 1905, inorganic arsenicals, like Fowler's solution, saw diminished use as attention turned to organic arsenicals, starting ... As arsenical compounds are notably toxic and carcinogenic-with side effects such as cirrhosis of the liver, idiopathic portal ... "A history of the use of arsenicals in man" (pdf). Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007 . PMID ...

https://en.wikipedia.org/wiki/Fowler's_solution

"Chronic arsenical poisoning due to environmental pollution. Seven cases among inhabitants near an abandoned mine." (1976). ...

https://en.wikipedia.org/wiki/Toroku_arsenic_disease

Common laborers only had arsenical copper objects. The precious metal objects then clearly demonstrate a hierarchy within the ... over two-thirds of which were objects of arsenical bronze, tumbaga (low-karat gold), silver and copper alloys, and high-karat ... The greatness of Middle Sican metallurgy was the large scale smelting and diverse use of arsenical copper, which was more ...

https://en.wikipedia.org/wiki/Sican_culture

Orlando, FL: Academic Press, 1986, 347-372; Uthus E.O., Evidency for arsenical essentiality, Environ. Geochem. Health, 1992, 14 ...

https://en.wikipedia.org/wiki/Mineral_(nutrient)

in oxidized zones of arsenical ores containing zinc. The type locality is the Daniel Mine (St. Daniel Mine), Neustädtel, ...

https://en.wikipedia.org/wiki/Köttigite

Outbreaks can be treated with an arsenical spray. Mating Eggs Larvae feeding on Quercus texana Larva Pupa Tuskes, Paul M.; P. ...

https://en.wikipedia.org/wiki/Anisota_virginiensis

Bruhn, D. F.; Li, J.; Silver, S.; Roberto, F.; Rosen, B. P. (1996-06-01). "The arsenical resistance operon of IncN plasmid R46 ...

https://en.wikipedia.org/wiki/ArsB_and_ArsAB_transporters

Arsenical bronze artifacts of the Maykop culture in the North Caucasus have been dated around the 4th millennium BC. This ... However, the Maykop culture only had arsenical bronze. Other regions developed bronze and its associated technology at ... innovation resulted in the circulation of arsenical bronze technology over southern and eastern Europe. The Yamna culture is a ...

https://en.wikipedia.org/wiki/Bronze_Age

Arsenical copper is one such limited research topic with some experimental work done by Pollard, Thomas, and Williams. Through ... Some Experiments Concerning the Smelting of Arsenical Copper. In P. Budd (ed.) Archaeological Sciences 169-174. Oxford, Oxbow ... implying that arsenical copper may have been the result of early smelting technologies where temperatures where unable to pass ...

https://en.wikipedia.org/wiki/Experimental_archaeometallurgy

The arsenical resistance-3 (ACR3) family (TC# 2.A.59) is a member of the BART superfamily. Based on operon analyses, ARC3 ... "2.A.59 The Arsenical Resistance-3 (ACR3) Family". Transporter Classification Database. Retrieved 2016-03-13. Wysocki, R.; ...

https://en.wikipedia.org/wiki/ARC3_family

... or thiacetarsamide (trade name Caparsolate) is an arsenical. It is a proposed chemotherapeutic agent against filaria ...

https://en.wikipedia.org/wiki/Arsenamide

Dodmane, PR, Arnold, LL, Pennington, KL, Singh, RK, Cardoso, APF & Cohen, SM 2015, Effect of trivalent arsenicals on cell ... Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. / Dodmane, Puttappa R. ... Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. In: Toxicology Reports ... Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. Toxicology Reports. ...

https://nebraska.pure.elsevier.com/en/publications/effect-of-trivalent-arsenicals-on-cell-proliferation-in-mouse-and

Arsenical copper contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced ... Arsenical bronze Rollason, EC (1949). Metallurgy for Engineers (2nd ed.). London: Arnold. "Archived copy". Archived from the ... Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. ...

https://en.wikipedia.org/wiki/Arsenical_copper

Arsenical bronze has seen little use in the modern period. It appears that the closest equivalent goes by the name of arsenical ... Arsenical copper Charles, J. A. (January 1967). "Early Arsenical Bronzes - A Metallurgical view". American Journal of ... saw the use of arsenical bronze. Indeed, it seems that arsenical bronze was the most common alloy in use in the Mediterranean ... to be traded and used to make arsenical bronze elsewhere by addition to molten copper. Artifacts made of arsenical bronze cover ...

https://en.wikipedia.org/wiki/Arsenical_bronze

encoded search term (Arsenical Keratosis) and Arsenical Keratosis What to Read Next on Medscape. Related Conditions and ... arsenical keratosis in 7.1%, and skin cancers in 1.5%. Of the 428 people with skin cancer, 72% also presented with arsenical ... Arsenical keratosis is not a fatal disease, but it may persist indefinitely and can become bothersome over time because of pain ... Arsenical cancer of skin. Histologic study with special reference to Bowens disease. Cancer. 1968 Feb. 21(2):312-39. [Medline] ...

https://emedicine.medscape.com/article/1099882-overview

aliphatic organic arsenicals synonyms, aliphatic organic arsenicals pronunciation, aliphatic organic arsenicals translation, ... English dictionary definition of aliphatic organic arsenicals. aliphatic straight chain of carbon atoms of a propane molecule ... redirected from aliphatic organic arsenicals). Also found in: Thesaurus, Medical, Encyclopedia. aliphatic. straight chain of ... Aliphatic organic arsenicals - definition of aliphatic organic arsenicals by The Free Dictionary https://www.thefreedictionary. ...

https://www.thefreedictionary.com/aliphatic+organic+arsenicals

Arsenical silver synonyms, Arsenical silver pronunciation, Arsenical silver translation, English dictionary definition of ... Arsenical silver. an ore of silver containing arsenic. See also: Arsenical ... Arsenical silver - definition of Arsenical silver by The Free Dictionary https://www.thefreedictionary.com/Arsenical+silver ... a href=https://www.thefreedictionary.com/Arsenical+silver,Arsenical silver,/a,. *Facebook ...

https://www.thefreedictionary.com/Arsenical+silver

encoded search term (Arsenical Keratosis) and Arsenical Keratosis What to Read Next on Medscape. Related Conditions and ... Another type of arsenical keratosis seen in most patients with arsenical cancers manifests as scaly erythematous or pigmented ... Arsenical Keratosis Clinical Presentation. Updated: Apr 02, 2018 * Author: Chih-Shan Jason Chen, MD, PhD; Chief Editor: Dirk M ... Arsenical keratoses are usually multiple and typically occur at sites of friction and trauma, especially on the palms and the ...

https://emedicine.medscape.com/article/1099882-clinical

Background - Organic Arsenical Pesticides. MSMA is an organic arsenical, a class of herbicides that also includes DSMA, CAMA, ... Monosodium Methanearsonate (MSMA), an Organic Arsenical. Monosodium methanearsonate (MSMA) is an organic arsenical pesticide ... Following application, organic arsenicals like MSMA convert over time to a more toxic form in soil (inorganic arsenic) and can ... The Organic Arsenicals; Amendments to Terminate Uses; Amendment to Existing Stocks Provisions - FR Notice, March 27, 2013 ...

https://www.epa.gov/ingredients-used-pesticide-products/monosodium-methanearsonate-msma-organic-arsenical

Inorganic arsenicals impact on vegetative growth of two sunflower (Helianthus annuus L.) cultivars (FH-385 as Hybrid 1 and FH- ... Impact of Inorganic Arsenicals on Vegetative Growth of Two Pakistani Origins Sunflower Cultivars. Muhammad Asif Imran,1 Feroza ...

https://www.hindawi.com/journals/jchem/2015/275830/abs/

This page contains information on the chemical Arsenical pesticides including: 10 synonyms/identifiers; U.S. Code of Federal ... Arsenical pesticide, liquid*Arsenical pesticide, liquid, poisonous*Arsenical pesticide, liquid, toxic*Arsenical pesticide, ... Arsenical pesticides*Arsenical pesticides, liquid, flammable, toxic, flash point less than 23 degrees C*Arsenical pesticides, ... Arsenical pesticides, solid, toxic*Arsenical pesticides, toxic. 49 CFR 172.101 - Hazardous Materials Table. Hazardous materials ...

https://environmentalchemistry.com/yogi/chemicals/cn/Arsenical%A0pesticides.html

ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS. Contact. National Health and Environmental Effects Research ... ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED TRIVALENT ARSENICALS. Z Drobna1, I Jaspers2, D J Thomas3 and M Styblo1. ... Western blot analyses of the MAPK enzyme family in cells exposed to trivalent arsenicals showed a significant increase in p-ERK ... ACTIVATION OF AP-1 IN UROTSA CELLS BY METHYLATED ARSENICALS. Presented at Society of Toxicology, Nashville, TN, March 17-21, ...

https://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=62228&keyword=IAS+AND+17&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=90556721&CFTOKEN=93772159

Article Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells. Clark 1 (diphenylarsine chloride) and ... Please sign in or create your free account to view the content of Accumulation and toxicity of monophenyl arsenicals in rat ... Accumulation and toxicity of monophenyl arsenicals in rat ... You have requested access to an area of the website which ...

https://www.environmental-expert.com/articles/accumulation-and-toxicity-of-monophenyl-arsenicals-in-rat-endothelial-cells-5054/full-article

arsenical resistance operon repressor, putative. A, B. 96. Archaeoglobus fulgidus DSM 4304. Mutation(s): 3 Gene Names: AF_0168 ... Crystal Structure of the putative arsenical resistance operon repressor from Archaeoglobus fulgidus. Kim, Y., Joachimiak, A., ... Crystal Structure of the putative arsenical resistance operon repressor from Archaeoglobus fulgidus. *DOI: 10.2210/pdb1Y0U/pdb ...

https://www.rcsb.org/structure/1Y0U

Arsenical-resistance proteinImported. ,p>Information which has been imported from another database using automatic procedures ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... tr,B0TB51,B0TB51_HELMI Arsenical-resistance protein OS=Heliobacterium modesticaldum (strain ATCC 51547 / Ice1) OX=498761 GN= ...

https://www.uniprot.org/uniprot/B0TB51

... A. ... describes a case of wide mandibular bone necrosis associated with significant soft tissues injury after using an arsenical ...

https://www.hindawi.com/journals/crid/2013/723753/abs/

The arsD gene encodes a second trans-acting regulatory protein of the plasmid-encoded arsenical resistance operon.. Wu J1, ... The plasmid-encoded arsenical resistance (ars) operon produces resistance to trivalent and pentavalent salts of arsenic and ...

https://www.ncbi.nlm.nih.gov/pubmed/8326869?dopt=Abstract

Arsenical-resistance proteinImported. ,p>Information which has been imported from another database using automatic procedures ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... IPR004706 Arsenical-R_Acr3. IPR002657 BilAc:Na_symport/Acr3. IPR038770 Na+/solute_symporter_sf. ... tr,A5FFK0,A5FFK0_FLAJ1 Arsenical-resistance protein OS=Flavobacterium johnsoniae (strain ATCC 17061 / DSM 2064 / UW101) OX= ...

https://www.uniprot.org/uniprot/A5FFK0

Arsenic toxicity (Arsenicism, Arsenicosis, Arsenical Keratoses, Arsenical pigmentation, Mees lines Kathleen Rossy ... There is no pit formation with arsenical keratoses. Verruca vulgaris. Arsenical keratoses differ because the large number of ... Close more info about Arsenic toxicity (Arsenicism, Arsenicosis, Arsenical Keratoses, Arsenical pigmentation, Mees lines ... Close more info about Arsenic toxicity (Arsenicism, Arsenicosis, Arsenical Keratoses, Arsenical pigmentation, Mees lines ...

https://www.clinicaladvisor.com/home/dermatology/arsenic-toxicity-arsenicism-arsenicosis-arsenical-keratoses-arsenical-pigmentation-mees-lines/

... have increased uptake of methylated arsenicals, which leads to increased cytotoxicity, as compared with inorganic arsenicals. ... The Novel Arsenical Darinaparsin Is Transported by Cystine Importing Systems. Nicolas Garnier, Geneviève G. J. Redstone, ... The Novel Arsenical Darinaparsin Is Transported by Cystine Importing Systems Message Subject (Your Name) has forwarded a page ... Here, we propose this route of cell entry may also exist for arsenicals and is likely to be specific to cysteine-S-conjugated ...

http://molpharm.aspetjournals.org/content/85/4/576

Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A) ... f5: Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A ... f5: Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (A ... Cells were treated 1 day after confluence with DMI in the absence (control) or presence of arsenicals. Vehicle, growth medium ...

https://openi.nlm.nih.gov/detailedresult.php?img=PMC3569692_ehp.1205731.g005&req=4

Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei. Enock Matovu, Mhairi L. Stewart, Federico ... Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei. Enock Matovu, Mhairi L. Stewart, Federico ... Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei. Enock Matovu, Mhairi L. Stewart, Federico ... Mechanisms of Arsenical and Diamidine Uptake and Resistance in Trypanosoma brucei Message Subject (Your Name) has forwarded a ...

https://ec.asm.org/content/2/5/1003/article-info

... and pentavalent arsenicals (MMA(V) and DMA(V)) were present as end products of metabolism, rather than intermediates. We also ... but not pentavalent arsenicals were bound to proteins in vitro, it was deduced that arsenic metabolites bound to proteins ... The relative ratios of the three arsenicals changed depending on organ, fraction (HMW and SED), and time. Since the arsenic ... Raman spectra of thiolated arsenicals with biological importance.. *Mingwei Yang, Yuzhen Sun, +4 authors Yong Cai ...

https://www.semanticscholar.org/paper/Trivalent-arsenicals-are-bound-to-proteins-during-Naranmandura-Suzuki/0030b20b49fcd20afcc29712294c94f463d1a707

In this case, 2010 sales of arsenicals would be even higher, as the reduction in arsenical sales needed to achieve a net ... of arsenicals were sold for use in food animals in 2010, the most recent year for which we can determine arsenical sales. ... In that event, more than 700,000 kg of arsenicals may once again be sold for use in producing our food, with a known carcinogen ... In other words, drug companies sold at least 706,530 kg of arsenicals in 2010; the actual quantity could be higher, but we ...

https://livablefutureblog.com/2012/10/fda-can%E2%80%99t-keep-a-secret%E2%80%94agency-accidently-reveals-arsenical-drug-sales-2

... Home , Publications , A peptide trivalent arsenical inhibits tumor angiogenesis by perturbing mitochondrial function in ...

https://www.centenary.org.au/cen_publication/a-peptide-trivalent-arsenical-inhibits-tumor-angiogenesis-by-perturbing-mitochondrial-function-in-angiogenic-endothelial-cells/

Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump. Adrian R. WALMSLEY, Tongqing ... The ArsA ATPase is the catalytic subunit of the pump protein, coupling the hydrolysis of ATP to the movement of arsenicals and ... Abbreviations used: ArsAB, Escherichia coli arsenical pump; Sb(III), antimonite (i.e. potassium antimonyl tartrate); ABC, ATP- ... Antimonite regulation of the ATPase activity of ArsA, the catalytic subunit of the arsenical pump ...

http://www.biochemj.org/content/360/3/589

"A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by ... The Bureau of Mines investigated a silver-catalyzed oxidative procedure for leaching an arsenical copper sulfide concentrate ... Silver-Catalyzed Oxidative Leaching of an Arsenical Copper Sulfide Concentrate; Bureau of Mines Report of Investigations -1987 ... Calcium chloride-oxygen leaching and metals recovery from an arsenical copper-cobalt concentrate ...

https://stacks.cdc.gov/view/cdc/10702

"Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial, International ... Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I clinical trial. Elliott, M.A.; Ford ... Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for Phase I... Elliott, M.A.; Ford, S.J.; ... A peptide trivalent arsenical inhibits tumour angiogenesis by perturbing mitochondrial function in angiogenic endothelial cells ...

https://www.deepdyve.com/lp/elsevier/pharmaceutical-development-of-the-novel-arsenical-based-cancer-N40O9z0qQa

Arsenicals. Known as: Arsenic Compounds, Arsenic Compound, arsenical Expand. A white, odorless, inorganic substance that ... Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). According to the postulated… Expand ... Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells ... The reactivities of methyloxoarsine (MAs(III)) and iododimethylarsine (DMAs(III)), two methylated trivalent arsenicals, toward ...

https://www.semanticscholar.org/topic/Arsenicals/94052

Arsenicals. Last Updated on Mon, 13 Nov 2017 , Pharmacology Melarsoprol (trivalent) and tryparsamide (pentavalent) are organic ... The arsenicals are trypanocidal. Melarsoprol is highly active against all stages of trypanosomiasis, but its toxicity restricts ...

https://www.alpfmedical.info/pharmacology/arsenicals.html

Antonyms for arsenical stomatitis. 4 words related to stomatitis: inflammation, redness, rubor, vesicular stomatitis. What are ... Arsenical stomatitis synonyms, arsenical stomatitis antonyms - FreeThesaurus.com https://www.freethesaurus.com/arsenical+ ... redirected from arsenical stomatitis). Also found in: Dictionary, Medical, Encyclopedia. #vtZoom,.vt-link{cursor:pointer} .vt- ... www.freethesaurus.com/arsenical+stomatitis,FreeThesaurus.com,/a,,/div, ,!--End of Graphic Thesaurus by FreeThesaurus.com--,. ...

https://www.freethesaurus.com/arsenical+stomatitis

Arsenical-induced carcinogenesis in human bladder has been established through epidemiological evidence, but unfortunately, no ... in damage caused in the bladder by arsenicals. Because ROS has been linked to MAPK signaling, it was shown that 50 nM MMA(III) ... providing additional models for studying arsenical-induced carcinogenesis of the bladder. These transformed cell lines allow ... into signaling pathway alterations that can lead to carcinogenesis in the human bladder upon exposure to arsenicals. In acute ...

https://repository.arizona.edu/handle/10150/195706

Overall, cytotoxicity of trivalent arsenicals to microvascular endothelial cells is similar to their cytotoxicity to epithelial cells, and that these compounds are not mitogenic. (elsevier.com)

The endothelial cells treated with1nM to 1μM concentrations of the three trivalent arsenicals did not show increased cell proliferation at 24, 48 or 72h or increased rate of proliferation at 72h of exposure. (elsevier.com)
Both cell lines showed similar LC50 values, from 0.1 to 2.4μM, for all three trivalent arsenicals. (elsevier.com)

Lower levels of inorganic arsenicals are known to be chemical carcinogens. (medscape.com)
Inorganic arsenicals impact on vegetative growth of two sunflower ( Helianthus annuus L.) cultivars (FH-385 as Hybrid 1 and FH-405 as Hybrid 2) was monitored. (hindawi.com)
Chronic exposures to inorganic arsenicals (iAs) increase risks of various types of cancer in humans. (epa.gov)
Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). (semanticscholar.org)
Florida International University (FIU) is pursuing commercial partners interested in developing Biosensor for organic and inorganic arsenicals . (fiu.edu)
The nonpathogenic bacterial biosensor developed by FIU can discriminate between the organic and inorganic arsenicals which is vital since arsenic is a toxic metalloid listed by the U.S. Environmental Protection Agency's (EPA) superfund list as a first of Hazardous Chemicals. (fiu.edu)
High selectivity between organic and inorganic arsenicals. (fiu.edu)
Substances such as inorganic arsenicals (sodium arsenite, arsenic trioxide), organic arsenicals (methyl arsonate, methyl arsonic acid), sodium chlorate, ammonium sulfamate, borax, and many others were formerly used on a large scale. (msdvetmanual.com)
The use of inorganic arsenicals as herbicides has been reduced greatly because of livestock losses, environmental persistence, and their carcinogenic potential. (msdvetmanual.com)

Arsenical compounds are used in industrial, agricultural, and medicinal substances. (medscape.com)
Overall, cytotoxicity of trivalent arsenicals to microvascular endothelial cells is similar to their cytotoxicity to epithelial cells, and that these compounds are not mitogenic. (elsevier.com)
Melarsen oxide, one of the arsenical drugs often administered to people with African sleeping sickness, can lose effectiveness due to the presence of three compounds: adenine, adenosine and dipyridamole. (readabstracts.com)
Wahlberg JE, Boman A. Contact sensitivity to arsenical compounds. (springer.com)

Please sign in or create your free account to view the content of Accumulation and toxicity of monophenyl arsenicals in rat endothelial cells . (environmental-expert.com)

It remains legal to purchase and use organic arsenical herbicides according to label directions and precautions. (epa.gov)
When used according to the label, organic arsenical herbicides do not pose an imminent hazard. (epa.gov)
Signs and lesions caused by organic arsenical herbicides resemble those of inorganic arsenical poisoning. (msdvetmanual.com)

The plasmid-encoded arsenical resistance (ars) operon produces resistance to trivalent and pentavalent salts of arsenic and antimony. (nih.gov)

Monosodium methanearsonate (MSMA) is an organic arsenical pesticide currently registered for use in the United States. (epa.gov)
Groundwater may also contain elevated concentrations of arsenic due to contamination from arsenical pesticide runoff. (cdc.gov)

Arsenic also causes pigment changes and (very frequently) hyperkeratotic lesions of the skin called arsenical keratoses. (medscape.com)
Arsenical keratoses are the most characteristic skin feature of long-term arsenic exposure. (medscape.com)
These in vitro findings may have revealed part of the pathogenesis of arsenical keratoses. (medscape.com)
Arsenical keratoses are usually multiple and typically occur at sites of friction and trauma, especially on the palms and the soles. (medscape.com)
Arsenical keratoses are multiple, symmetric, yellow hyperkeratotic papules that range from 0.2-1 cm in size. (clinicaladvisor.com)
Arsenical keratoses have compact hyperkeratosis and acanthosis. (clinicaladvisor.com)
There is no pit formation with arsenical keratoses. (clinicaladvisor.com)
Arsenical keratoses differ because the large number of symmetric lesions, the lack of pinpoint bleeding with paring of lesions, and the other associated findings ( ie, cutaneous melanosis and nail changes). (clinicaladvisor.com)

Arsenical keratosis on the sole of a carpenter. (medscape.com)
Another type of arsenical keratosis seen in most patients with arsenical cancers manifests as scaly erythematous or pigmented patches on unexposed body areas. (medscape.com)
Arsenical keratosis occasionally evolves into carcinoma after a number of years. (medscape.com)
This also presents with yellow, symmetric hyperkeratotic papules of the palms and soles, but differs from arsenical keratosis because when the papule is removed a pit is formed. (clinicaladvisor.com)

Only trivalent arsenicals (arsenic trioxide and sodium m-arsenite), but not pentavalent arsenicals (arsenic acid and p-arsenilic acid), induced significant cell injury. (elsevier.com)

The arsD gene encodes a second trans-acting regulatory protein of the plasmid-encoded arsenical resistance operon. (nih.gov)
In addition in wild-type strains of Streptomyces phosphate sensitivity of antibiotic biosynthesis did not show strong correlation with resistance of growth to arsenicals. (microbiologyresearch.org)
We now recognize that resistance to arsenicals and antimonials is widespread, occurring in bacteria, fungi, protozoans, and animal cells ( 44 ). (asm.org)
Bacterial operons encoding resistance to arsenicals and antimonials ( ars operons) can be found on transmissible plasmids and in chromosomes. (asm.org)

UROtsa cells were shown to be malignantly transformed following low-level exposure to both arsenite [As(III)] and its more toxic metabolite, monomethylarsonous acid [MMA(III)] providing additional models for studying arsenical-induced carcinogenesis of the bladder. (arizona.edu)
These transformed cell lines allow researchers the ability to investigate the process of urothelial tumorigenesis at multiple time points of arsenical exposure. (arizona.edu)
UROtsa cells were exposed to As(III) and MMA(III) both acutely and chronically to begin investigations into signaling pathway alterations that can lead to carcinogenesis in the human bladder upon exposure to arsenicals. (arizona.edu)
These data clearly present evidence supporting a role for ROS in both acute and chronic toxicities associated with low-level arsenical exposure, and gives evidence that ROS are important in cellular transformation following MMA(III) exposure. (arizona.edu)
The endothelial cells treated with1nM to 1μM concentrations of the three trivalent arsenicals did not show increased cell proliferation at 24, 48 or 72h or increased rate of proliferation at 72h of exposure. (elsevier.com)

MSMA is an organic arsenical, a class of herbicides that also includes DSMA, CAMA, cacodylic acid and its sodium salt. (epa.gov)

Unctuous substances of the consistence of, prix du cialis 20mg en france, convalescents from infectious diseases patients with healing chest, do you need a prescription for cialis in uk, they would rather take the germs than the chlorine. (healthybaking.org)

Arsenical copper contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced tendency to scaling. (wikipedia.org)
Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. (wikipedia.org)
Arsenical bronze is an alloy in which arsenic, as opposed to or in addition to tin or other constituent metals, is added to copper to make bronze. (wikipedia.org)
They suggest that iron arsenide was deliberately produced as part of the copper-smelting process, to be traded and used to make arsenical bronze elsewhere by addition to molten copper. (wikipedia.org)
There is evidence of arsenical bronze daggers from the Caucasus and other artifacts from different locations having an arsenic-rich surface layer which may well have been produced deliberately by ancient craftsmen, and Mexican bells were made of copper with sufficient arsenic to colour them silver. (wikipedia.org)
The Bureau of Mines investigated a silver-catalyzed oxidative procedure for leaching an arsenical copper sulfide concentrate containing 10 pct As and 32 pct Cu_ Currently, there are no environmentally safe means to treat arsenical copper concentrates in the United States. (cdc.gov)
Three chemical mixtures are common to wood preservation - pentachlorophenol, creosote, and arsenicals (primarily copper chromium arsenate or CCA). (beyondpesticides.org)

We have investigated the effects of the organic arsenical, melarsoprol (a drug used for treatment of trypanosomiasis), upon induction of apoptosis in cell lines representative of chronic B-cell lymphoproliferative disorders. (biomedsearch.com)

Arsenic is a Arsenical compound. (pesticideinfo.org)

On the other hand, arsenical and antimonial drugs are so toxic to humans that their use was difficult to manage. (asm.org)

Following application, organic arsenicals like MSMA convert over time to a more toxic form in soil (inorganic arsenic) and can contaminate drinking water through soil runoff. (epa.gov)
The highly soluble organic arsenicals can concentrate in pools in toxic quantities after a rain has washed them from recently treated plants. (msdvetmanual.com)
Arsenicals are used as desiccants or defoliants on cotton, and residues of cotton harvest fed to cattle may contain toxic amounts of arsenic. (msdvetmanual.com)

Here his research focused on testing arsenical dyes for killing microbes. (wikipedia.org)

Probing the structure of pyruvate dehydrogenase multienzyme complex from Escherichia coli with trivalent arsenicals (Unpublished doctoral thesis). (ucalgary.ca)

A-receptor loosened arsenicals, trypanosomiasis proceed. (otkrovenie.net)

The use of arsenic-based drugs, known as "arsenicals," in poultry and pork production is one of the more disturbing practices of the food animal industry (and that is saying something). (livablefutureblog.com)
Antimicrobials include antibiotics such as penicillin and tetracycline, as well as drugs like arsenicals, used against pathogens in the intestines. (livablefutureblog.com)
Indeed, when one compares the initial and revised reports, one sees that the net decrease of 705,476 kg in total antimicrobial sales resulted from a 1,054-kg increase in cephalosporin sales (the "late data submission") and a 706,530-kg decrease in sales of drugs grouped together in the "not independently reported" (NIR) category-the "sales data for a class of drug (arsenicals) that was inappropriately included. (livablefutureblog.com)
In this case, 2010 sales of arsenicals would be even higher, as the reduction in arsenical sales needed to achieve a net decrease of 706,530 kg in sales of NIR drugs despite an increase in sales of other NIR drugs would be higher. (livablefutureblog.com)

Thiolated arsenicals in arsenic metabolism: Occurrence, formation, and biological implications. (semanticscholar.org)

A) Effects of various arsenicals on the expression of CHOP10 protein in the early stage of adipogenesis. (nih.gov)
The ArsA ATPase is the catalytic subunit of the pump protein, coupling the hydrolysis of ATP to the movement of arsenicals and antimonials through the membrane-spanning ArsB protein. (biochemj.org)

Inorganic arsenic is a known human carcinogen , and the use of arsenicals to produce food animals is known to increase concentrations of inorganic arsenic in parts of animals that people eat. (livablefutureblog.com)

Trivalent arsenicals are bound to proteins during reductive methylation. (semanticscholar.org)

Arsenical bronze Rollason, EC (1949). (wikipedia.org)
hence, the term "arsenical bronze" when used in archaeology is typically only applied to alloys with an arsenic content higher than 1% by weight, in order to distinguish it from potentially accidental additions of arsenic. (wikipedia.org)
Although arsenical bronze occurs in the archaeological record across the globe, the earliest artifacts so far known, dating from the 5th millennium BCE, have been found on the Iranian plateau. (wikipedia.org)
Using these various ores, there are four possible methods that may have been used to produce arsenical bronze alloys. (wikipedia.org)
Artifacts made of arsenical bronze cover the complete spectrum of metal objects, from axes to ornaments. (wikipedia.org)

Current chemical tests and Biosensors detect only inorganic arsenic and total organic arsenicals. (fiu.edu)

Western blot analyses of the MAPK enzyme family in cells exposed to trivalent arsenicals showed a significant increase in p-ERK but not in p-JNK or in p-p38 levels. (epa.gov)

Effects of arsenicals on the DMI-induced reduction of CHOP10 in the early stage of adipogenesis in 3T3-L1 preadipocytes. (nih.gov)

This paper describes a case of wide mandibular bone necrosis associated with significant soft tissues injury after using an arsenical endodontic preparation in the right lower second molar for endodontic purpose. (hindawi.com)
Since the intracellular reduced glutathione (GSH) plays an important role in detoxication in mammalian cells, its effect on arsenical-induced cell injury was then studied. (elsevier.com)

Arsenical squamous cell carcinoma occurs less frequently than Bowen disease, but it appears to be more aggressive than sun-induced squamous cell carcinoma. (medscape.com)

Cells were treated 1 day after confluence with DMI in the absence (control) or presence of arsenicals. (nih.gov)

Arsenical-induced carcinogenesis in human bladder has been established through epidemiological evidence, but unfortunately, no mode of action had been determined for this phenomenon. (arizona.edu)

For years, the drug and food animal industries have refused to reveal the extent of their arsenical sales and use. (livablefutureblog.com)
Now, after careful review of FDA reports and correspondence, I can publish a number that neither FDA nor these industries want you to know: 706,530 kilograms (kg) of arsenicals were sold for use in food animals in 2010, the most recent year for which we can determine arsenical sales. (livablefutureblog.com)

Anatomy2

Organisms5

Diseases4

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes8

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture1

Health Care1

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (1/1135)

NADPH oxidase inhibition does not interfere with low PO2 transduction in rat and rabbit CB chemoreceptor cells. (2/1135)

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. (3/1135)

Interference in the quantitation of methylated arsenic species in human urine. (4/1135)

Phenylarsine oxide and ethanol prevent cell death of porcine polymorphonuclear leucocytes induced by phorbol myristate acetate. (5/1135)

Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen. (6/1135)

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (7/1135)

Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. (8/1135)

Arsenicals

Arsenic

Arsenic Poisoning

Cacodylic Acid

Arsenites

Melarsoprol

Ion Pumps

Arsenite Transporting ATPases

Antimony

Arsenates

Roxarsone

Trypanocidal Agents

Dimercaprol

Diminazene

Pentamidine

Oxides

Aquaglyceroporins

Bowen's Disease

Sodium Compounds

Water Pollutants, Chemical

Drinking Water

Nucleoside Transport Proteins

Methylation

R Factors

Methyltransferases

Trypanosoma brucei brucei

Urothelium

Glutathione

Crithidia fasciculata

Trypanosoma

Skin Diseases

Organometallic Compounds

Spectrophotometry, Atomic

Trypanosomiasis, African

Sulfides

Medicine, Traditional

Sulfhydryl Compounds

Operon

Multienzyme Complexes

Urinary Bladder

Drug Resistance

Cysteine

Adenosine Triphosphatases

Biotransformation

Carcinogens

Rats, Inbred F344

Escherichia coli

Environmental Exposure

Kinetics

Drug Resistance, Microbial

Disulfides

Dose-Response Relationship, Drug

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (1/1135)

NADPH oxidase inhibition does not interfere with low PO2 transduction in rat and rabbit CB chemoreceptor cells. (2/1135)

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. (3/1135)

Interference in the quantitation of methylated arsenic species in human urine. (4/1135)

Phenylarsine oxide and ethanol prevent cell death of porcine polymorphonuclear leucocytes induced by phorbol myristate acetate. (5/1135)

Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen. (6/1135)

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (7/1135)

Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. (8/1135)

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells<...

Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as...

Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells | Molecular Cancer | Full Text

Phenylarsine oxide - Substance Information - ECHA

An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond.

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Masuda Tomoyuki | TRIOS

Gallium Arsenide Market Overview, Scope And Chemical Research 2018 | Trade Calls

Arsenic trioxide: Its use in the treatment of acute promyelocytic leukemia<...

Arsenides Exporter, Manufacturer, Distributor, Supplier, Trading Company, Arsenides India

Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients With Acute Myeloid Leukemia - Tabular...

Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia

Study of Arsenic Trioxide in Small Cell Lung Cancer - Full Text View - ClinicalTrials.gov

Arsenic Trioxide - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki

ARSENIC TRIOXIDE (ARSENITE)

Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...

Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...

Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive...

arsenic trioxide Intravenous - patient information, description, dosage and directions.

$Gentaur Molecular :Ato \ 100V 120V AC adapter for FLAT Viewer \ 2196161$ Gentaur Molecular :Ato \ 100V 120V AC adapter for FLAT Viewer \ 2196161

$Gentaur Molecular :Ato \ EA 25 Column End Assembly \ 1293622$ Gentaur Molecular :Ato \ EA 25 Column End Assembly \ 1293622

$Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia$ Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia