AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureHealth Care
ArsenicalsArsenicArsenic PoisoningCacodylic AcidArsenitesMelarsoprolIon PumpsArsenite Transporting ATPasesAntimonyArsenatesRoxarsoneTrypanocidal AgentsDimercaprolDiminazenePentamidineOxidesAquaglyceroporinsBowen's DiseaseSodium CompoundsWater Pollutants, ChemicalDrinking WaterNucleoside Transport ProteinsMethylationR FactorsMethyltransferasesTrypanosoma brucei bruceiUrotheliumGlutathioneCrithidia fasciculataTrypanosomaSkin DiseasesOrganometallic CompoundsSpectrophotometry, AtomicTrypanosomiasis, AfricanSulfidesMedicine, TraditionalSulfhydryl CompoundsOperonMultienzyme ComplexesUrinary BladderDrug ResistanceCysteineAdenosine TriphosphatasesBiotransformationCarcinogensRats, Inbred F344Escherichia coliEnvironmental ExposureKineticsDrug Resistance, MicrobialDisulfidesDose-Response Relationship, Drug
Arsenicals
Inorganic or organic compounds that contain arsenic.
Arsenic
A shiny gray element with atomic symbol As, atomic number 33, and atomic weight 75. It occurs throughout the universe, mostly in the form of metallic arsenides. Most forms are toxic. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), arsenic and certain arsenic compounds have been listed as known carcinogens. (From Merck Index, 11th ed)
Arsenic Poisoning
Disorders associated with acute or chronic exposure to compounds containing ARSENIC (ARSENICALS) which may be fatal. Acute oral ingestion is associated with gastrointestinal symptoms and an encephalopathy which may manifest as SEIZURES, mental status changes, and COMA. Chronic exposure is associated with mucosal irritation, desquamating rash, myalgias, peripheral neuropathy, and white transverse (Mees) lines in the fingernails. (Adams et al., Principles of Neurology, 6th ed, p1212)
Cacodylic Acid
An arsenical that has been used as a dermatologic agent and as an herbicide.
Arsenites
Inorganic salts or organic esters of arsenious acid.
Melarsoprol
Arsenical used in trypanosomiases. It may cause fatal encephalopathy and other undesirable side effects.
Ion Pumps
A general class of integral membrane proteins that transport ions across a membrane against an electrochemical gradient.
Arsenite Transporting ATPases
Efflux pumps that use the energy of ATP hydrolysis to pump arsenite across a membrane. They are primarily found in prokaryotic organisms, where they play a role in protection against excess intracellular levels of arsenite ions.
Antimony
A metallic element that has the atomic symbol Sb, atomic number 51, and atomic weight 121.75. It is used as a metal alloy and as medicinal and poisonous salts. It is toxic and an irritant to the skin and the mucous membranes.
Arsenates
Inorganic or organic salts and esters of arsenic acid.
Roxarsone
An arsenic derivative which has anticoccidial action and promotes growth in animals.
Trypanocidal Agents
Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
Dimercaprol
An anti-gas warfare agent that is effective against Lewisite (dichloro(2-chlorovinyl)arsine) and formerly known as British Anti-Lewisite or BAL. It acts as a chelating agent and is used in the treatment of arsenic, gold, and other heavy metal poisoning.
Diminazene
An effective trypanocidal agent.
Pentamidine
Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
Oxides
Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.
Aquaglyceroporins
A subgroup of aquaporins that transport WATER; GLYCEROL; and other small solutes across CELL MEMBRANES.
Bowen's Disease
A persistent progressive non-elevated red scaly or crusted plaque which is due to an intradermal carcinoma and is potentially malignant. Atypical squamous cells proliferate through the whole thickness of the epidermis. The lesions may occur anywhere on the skin surface or on mucosal surfaces. The cause most frequently found is trivalent arsenic compounds. Freezing, cauterization or diathermy coagulation is often effective. (From Rook et al., Textbook of Dermatology, 4th ed, pp2428-9)
Sodium Compounds
Inorganic compounds that contain sodium as an integral part of the molecule.
Water Pollutants, Chemical
Chemical compounds which pollute the water of rivers, streams, lakes, the sea, reservoirs, or other bodies of water.
Drinking Water
Water that is intended to be ingested.
Nucleoside Transport Proteins
Proteins involved in the transport of NUCLEOSIDES across cellular membranes.
Methylation
Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)
R Factors
A class of plasmids that transfer antibiotic resistance from one bacterium to another by conjugation.
Methyltransferases
A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.
Trypanosoma brucei brucei
A hemoflagellate subspecies of parasitic protozoa that causes nagana in domestic and game animals in Africa. It apparently does not infect humans. It is transmitted by bites of tsetse flies (Glossina).
Urothelium
The epithelial lining of the URINARY TRACT.
Glutathione
A tripeptide with many roles in cells. It conjugates to drugs to make them more soluble for excretion, is a cofactor for some enzymes, is involved in protein disulfide bond rearrangement and reduces peroxides.
Crithidia fasciculata
A species of monogenetic, parasitic protozoa usually found in insects.
Trypanosoma
A genus of flagellate protozoans found in the blood and lymph of vertebrates and invertebrates, both hosts being required to complete the life cycle.
Skin Diseases
Organometallic Compounds
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
Spectrophotometry, Atomic
Spectrophotometric techniques by which the absorption or emmision spectra of radiation from atoms are produced and analyzed.
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Sulfides
Chemical groups containing the covalent sulfur bonds -S-. The sulfur atom can be bound to inorganic or organic moieties.
Medicine, Traditional
Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.
Sulfhydryl Compounds
Compounds containing the -SH radical.
Operon
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
Multienzyme Complexes
Systems of enzymes which function sequentially by catalyzing consecutive reactions linked by common metabolic intermediates. They may involve simply a transfer of water molecules or hydrogen atoms and may be associated with large supramolecular structures such as MITOCHONDRIA or RIBOSOMES.
Urinary Bladder
A musculomembranous sac along the URINARY TRACT. URINE flows from the KIDNEYS into the bladder via the ureters (URETER), and is held there until URINATION.
Drug Resistance
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
Cysteine
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
Adenosine Triphosphatases
A group of enzymes which catalyze the hydrolysis of ATP. The hydrolysis reaction is usually coupled with another function such as transporting Ca(2+) across a membrane. These enzymes may be dependent on Ca(2+), Mg(2+), anions, H+, or DNA.
Biotransformation
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Carcinogens
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Rats, Inbred F344
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Environmental Exposure
The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.
Kinetics
The rate dynamics in chemical or physical systems.
Drug Resistance, Microbial
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).
Disulfides
Chemical groups containing the covalent disulfide bonds -S-S-. The sulfur atoms can be bound to inorganic or organic moieties.
Dose-Response Relationship, Drug
The relationship between the dose of an administered drug and the response of the organism to the drug.

Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient. (1/1135)

Primary blasts of a t(11;17)(q23;q21) acute promyelocytic leukaemia (APL) patient were analysed with respect to retinoic acid (RA) and arsenic trioxide (As2O3) sensitivity as well as PLZF/RARalpha status. Although RA induced partial monocytic differentiation ex vivo, but not in vivo, As203 failed to induce apoptosis in culture, contrasting with t(15;17) APL and arguing against the clinical use of As203 in t(11;17)(q23;q21) APL. Prior to cell culture, PLZF/RARalpha was found to exactly co-localize with PML onto PML nuclear bodies. However upon cell culture, it quickly shifted towards microspeckles, its localization found in transfection experiments. Arsenic trioxide, known to induce aggregation of PML nuclear bodies, left the microspeckled PLZF/RARalpha localization completely unaffected. RA treatment led to PLZF/RARalpha degradation. However, this complete PLZF/RARalpha degradation was not accompanied by differentiation or apoptosis, which could suggest a contribution of the reciprocal RARalpha/PLZF fusion product in leukaemogenesis or the existence of irreversible changes induced by the chimera.  (+info)

NADPH oxidase inhibition does not interfere with low PO2 transduction in rat and rabbit CB chemoreceptor cells. (2/1135)

The aim of the present work was to elucidate the role of NADPH oxidase in hypoxia sensing and transduction in the carotid body (CB) chemoreceptor cells. We have studied the effects of several inhibitors of NADPH oxidase on the normoxic and hypoxia-induced release of [3H]catecholamines (CA) in an in vitro preparation of intact CB of the rat and rabbit whose CA deposits have been labeled by prior incubation with the natural precursor [3H]tyrosine. It was found that diphenyleneiodonium (DPI; 0.2-25 microM), an inhibitor of NADPH oxidase, caused a dose-dependent release of [3H]CA from normoxic CB chemoreceptor cells. Contrary to hypoxia, DPI-evoked release was only partially Ca2+ dependent. Concentrations of DPI reported to produce full inhibition of NADPH oxidase in the rat CB did not prevent the hypoxic release response in the rat and rabbit CB chemoreceptor cells, as stimulation with hypoxia in the presence of DPI elicited a response equaling the sum of that produced by DPI and hypoxia applied separately. Neopterin (3-300 microM) and phenylarsine oxide (0.5-2 microM), other inhibitors of NADPH oxidase, did not promote release of [3H]CA in normoxic conditions or affect the response elicited by hypoxia. On the basis of effects of neopterin and phenylarsine oxide, it is concluded that NADPH oxidase does not appear to play a role in oxygen sensing or transduction in the rat and rabbit CB chemoreceptor cells in vitro and, in the context of the present study, that DPI effects are not related to NADPH oxidase inhibition.  (+info)

Arsenic trioxide and melarsoprol induce apoptosis in plasma cell lines and in plasma cells from myeloma patients. (3/1135)

Recent data have renewed the interest for arsenic-containing compounds as anticancer agents. In particular, arsenic trioxide (As2O3) has been demonstrated to be an effective drug in the treatment of acute promyelocytic leukemia by inducing programmed cell death in leukemic cells both in vitro and in vivo. This prompted us to study the in vitro effects of As2O3 and of another arsenical derivative, the organic compound melarsoprol, on human myeloma cells and on the plasma cell differentiation of normal B cells. At pharmacological concentrations (10(-8) to 10(-6) mol/L), As2O3 and melarsoprol caused a dose- and time-dependent inhibition of survival and growth in myeloma cell lines that was, in some, similar to that of acute promyelocytic leukemia cells. Both arsenical compounds induced plasma cell apoptosis, as assessed by 4',6-diamidino-2-phenylindole staining, detection of phosphatidylserine at the cell surface using annexin V, and by the terminal deoxynucleotidyl transferase-mediated nick end labeling assay. As2O3 and melarsoprol also inhibited viability and growth and induced apoptosis in plasma-cell enriched preparations from the bone marrow or blood of myeloma patients. In nonseparated bone marrow samples, both arsenical compounds triggered death in myeloma cells while sparing most myeloid cells, as demonstrated by double staining with annexin V and CD38 or CD15 antibodies. In primary myeloma cells as in cell lines, interleukin 6 did not prevent arsenic-induced cell death or growth inhibition, and no synergistic effect was observed with IFN-alpha. In contrast to As2O3, melarsoprol only slightly reduced the plasma cell differentiation of normal B cells induced by pokeweed mitogen. Both pokeweed mitogen-induced normal plasma cells and malignant plasma cells showed a normal nuclear distribution of PML protein, which was disrupted by As2O3 but not by melarsoprol, suggesting that the two arsenical derivatives acted by different mechanisms. These results point to the use of arsenical derivatives as investigational drugs in the treatment of multiple myeloma.  (+info)

Interference in the quantitation of methylated arsenic species in human urine. (4/1135)

The aim of this paper is to report on the presence of chemical interferences in the quantitation of methylated arsenic species in human urine when using a method based on selective volatile arsine species generation, chromatographic separation, and hydride generation atomic absorption spectrometry (HGAAS) detection. An abnormal profile of methylated arsenic species characterized by the absence of the peak corresponding to dimethylarsinic acid (DMA) was observed in urine from some individuals exposed to arsenic via drinking water and living in rural communities of northwestern Argentina. The absence of this peak persisted even after the addition of known amounts of DMA to the samples. However, the DMA peak appeared after urine digestion with hydrochloric acid (2M). Samples showing interferences were provided by individuals who had mate consumption and coca-leaf chewing habits. Because the relative proportions of methylated arsenic species present in urine have been used to evaluate the efficiency of the methylation process, interferences in the formation or detection of methylarsines may cause underestimation of As exposure and also lead to erroneous conclusions about relative biomethylation efficiencies. Therefore, we recommend that urine samples should be digested with 2M HCl before performing speciation analysis using HGAA techniques. Further studies on the impact of this type of interferences on other arsenic speciation methods are also required.  (+info)

Phenylarsine oxide and ethanol prevent cell death of porcine polymorphonuclear leucocytes induced by phorbol myristate acetate. (5/1135)

In this study, we report that phenylarsine oxide and ethanol, both of which suppress a number of polymorphonuclear leucocyte functions including superoxide production, prevented the phorbol myristate acetate-induced cell death in a dose-dependent manner. These reagents had an inhibitory effect even after polymorphonuclear leucocytes were stimulated to produce superoxide by treatment with phorbol myristate acetate. The results indicate that activation of protein kinase C and subsequent superoxide release do not directly cause phorbol myristate acetate-induced cell death. Phenylarsine oxide or ethanol prevents cell death by affecting pathways downstream from those involved in the superoxide production.  (+info)

Phosphatidylinositol 3'-kinase and tyrosine-phosphatase activation positively modulate Convulxin-induced platelet activation. Comparison with collagen. (6/1135)

In this report we have studied the role of phosphatidylinositol 3'-kinase (PI3-K) and tyrosine phosphatase activation on platelet activation by Convulxin (Cvx). Wortmannin, a specific PI3-K inhibitor, and phenylarsine oxide (PAO), a sulfhydryl reagent that inhibits tyrosine phosphatase (PTPase), block Cvx-induced platelet aggregation, granule secretion, inositol phosphate production, and increase in [Ca2+]i. However, PAO does not inhibit Cvx-induced tyrosine phosphorylation of platelet proteins, including Syk and PLCgamma2, but blocked collagen-induced platelet aggregation as well as tyrosine phosphorylation of PLCgamma2. In contrast, Cvx-induced PLCgamma2 tyrosyl phosphorylation was partially inhibited by wortmannin. We conclude that (i) although Cvx and collagen activate platelets by a similar mechanism, different regulatory processes are specific to each agonist; (ii) mechanisms other than tyrosine phosphorylation regulate PLCgamma2 activity; and (iii) besides protein tyrosine kinases, PI3-K (and PTPase) positively modulate platelet activation by both Cvx and collagen, and this enzyme is required for effective transmission of GPVI-Fc receptor gamma chain signal to result in full activation and tyrosine phosphorylation of PLCgamma2 in Cvx-stimulated platelets.  (+info)

Apoptosis and growth inhibition in malignant lymphocytes after treatment with arsenic trioxide at clinically achievable concentrations. (7/1135)

BACKGROUND: Arsenic trioxide (As2O3) can induce clinical remission in patients with acute promyelocytic leukemia via induction of differentiation and programmed cell death (apoptosis). We investigated the effects of As2O3 on a panel of malignant lymphocytes to determine whether growth-inhibitory and apoptotic effects of As2O3 can be observed in these cells at clinically achievable concentrations. METHODS: Eight malignant lymphocytic cell lines and primary cultures of lymphocytic leukemia and lymphoma cells were treated with As2O3, with or without dithiothreitol (DTT) or buthionine sulfoximine (BSO) (an inhibitor of glutathione synthesis). Apoptosis was assessed by cell morphology, flow cytometry, annexin V protein level, and terminal deoxynucleotidyl transferase labeling of DNA fragments. Cellular proliferation was determined by 5-bromo-2'-deoxyuridine incorporation into DNA and flow cytometry and by use of a mitotic arrest assay. Mitochondrial transmembrane potential (delta psi(m)) was measured by means of rhodamine 123 staining and flow cytometry. Protein expression was assessed by western blot analysis or immunofluorescence. RESULTS: Therapeutic concentrations of As2O3 (1-2 microM) had dual effects on malignant lymphocytes: 1) inhibition of growth through adenosine triphosphate (ATP) depletion and prolongation of cell cycle time and 2) induction of apoptosis. As2O3-induced apoptosis was preceded by delta psi(m) collapse. DTT antagonized and BSO enhanced As2O3-induced ATP depletion, delta psi(m) collapse, and apoptosis. Caspase-3 activation, usually resulting from delta psi(m) collapse, was not always associated with As2O3-induced apoptosis. As2O3 induced PML (promyelocytic leukemia) protein degradation but did not modulate expression of cell cycle-related proteins, including c-myc, retinoblastoma protein, cyclin-dependent kinase 4, cyclin D1, and p53, or expression of differentiation-related antigens. CONCLUSIONS: Substantial growth inhibition and apoptosis without evidence of differentiation were induced in most malignant lymphocytic cells treated with 1-2 microM As2O3. As2O3 may prove useful in the treatment of malignant lymphoproliferative disorders.  (+info)

Oxidative stress triggers STAT3 tyrosine phosphorylation and nuclear translocation in human lymphocytes. (8/1135)

Oxidizing agents are powerful activators of factors responsible for the transcriptional activation of cytokine-encoding genes involved in tissue injury. In this study we show evidence that STAT3 is a transcription factor whose activity is modulated by H2O2 in human lymphocytes, in which endogenous catalase had previously been inhibited. H2O2-induced nuclear translocation of STAT3 to form sequence-specific DNA-bound complexes was evidenced by immunoblotting of nuclear fractions and electrophoretic mobility shift assays, and vanadate was found to strongly synergize with H2O2. Moreover, anti-STAT3 antibodies specifically precipitated a protein of 92 kDa that becomes phosphorylated on tyrosine upon lymphocyte treatment with H2O2. Phenylarsine oxide, a tyrosine phosphatase inhibitor, and genistein, a tyrosine kinase inhibitor, cooperated and cancelled, respectively, the H2O2-promoted STAT3 nuclear translocation. Evidence is also presented, using Fe2+/Cu2+ ions, that.OH generated from H2O2 through Fenton reactions could be a candidate oxygen reactive species to directly activate STAT3. Present data suggest that H2O2 and vanadate are likely to inhibit the activity of intracellular tyrosine phosphatase(s), leading to enhanced STAT3 tyrosine phosphorylation and hence its translocation to the nucleus. These results demonstrate that the DNA binding activity of STAT3 can be modulated by oxidizing agents and provide a framework to understand the effects of oxidative stress on the JAK-STAT signaling pathway.  (+info)

Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells<...
TY - JOUR. T1 - Effect of trivalent arsenicals on cell proliferation in mouse and human microvascular endothelial cells. AU - Dodmane, Puttappa R.. AU - Arnold, Lora L. AU - Pennington, Karen L.. AU - Singh, Rakesh K. AU - Cardoso, Ana Paula Ferragut. AU - Cohen, Samuel Monroe. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Chronic exposure to high levels of inorganic arsenic (iAs) has been associated with cancerous and non-cancerous health effects, including cardiovascular effects. However, the mechanism for a presumed toxic effect of arsenic on vascular tissue is not clear. Our working hypothesis is that inorganic trivalent arsenic and its methylated metabolites react with cysteine-containing cellular proteins and alter their function leading to adverse events such as cytotoxicity or proliferation. In this study, human microvascular endothelial cells (HMEC1) and mouse microvascular endothelial cells (MFP-MVEC) were exposed to arsenite (iAsIII), monomethylarsonous acid (MMAIII), or dimethylarsinous acid ...
https://nebraska.pure.elsevier.com/en/publications/effect-of-trivalent-arsenicals-on-cell-proliferation-in-mouse-and
Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as...Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as...
Stock Photo 4128R-18191: Download Arsenic trioxide, molecular model. Precursor to arsenic compounds, including organoarsenic compounds. Atoms are represented as spheres and are colour_coded: arsenic violet and oxygen red. Stock Photos. Search over 12 million royalty free images and rights managed stock photography
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Targeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells | Molecular Cancer | Full TextTargeting metabolism with arsenic trioxide and dichloroacetate in breast cancer cells | Molecular Cancer | Full Text
During the last decade, ATO has been used effectively to treat both newly diagnosed and relapsed APL patients, with patients showing complete remission after low dose ATO treatment [4]. The anti-cancer ability of ATO is not limited to APL [36] and many other tumors in animal models have been shown to be sensitive to ATO treatment [37, 38]. However, the lack of information on sites of action for ATO cytotoxicity in tumor types other than APL has limited its uptake for the treatment of other cancers until recent years [5].. In this study, we have demonstrated that complex IV of the ETC is a target for ATO. From a panel of ETC inhibitors, the decrease in ROS, decrease in ATP production and MMP depolarisation caused by low dose ATO treatment of T-47D cells was reproduced only by cyanide, a well characterised complex IV inhibitor (Figure 5). Direct measurement of cytochrome C oxidase activity in whole cells treated with ATO confirmed the ability of ATO to inhibit this enzyme activity directly. The ...
https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-10-142
Phenylarsine oxide - Substance Information - ECHAPhenylarsine oxide - Substance Information - ECHA
Harmonised classification and labelling is a legally binding classification and labelling for a substance, agreed at European Community level. Harmonisation is based on the substances physical, toxicological and eco-toxicological hazard assessment. The Hazard classification and labelling section uses the signal word, pictogram(s) and hazard statements of the substance under the harmonised classification and labelling (CLH) as its primary source of information.. If the substance is covered by more than one CLH entry (e.g. disodium tetraborate EC no. 215-540-4, is covered by three harmonisations: 005-011-00-4; 005-011-01-1 and 005-011-02-9), CLH information cannot be displayed in the InfoCard as the difference between the CLH classifications requires manual interpretation or verification. If a substance is classified under multiple CLH entries, a link to the C&L Inventory is provided to allow users to view CLH information associated with the substance and no text is automatically ...
https://echa.europa.eu/sl/substance-information/-/substanceinfo/100.010.251
An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond.An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond.
Citation: Ritchie, A.W., Edmonds, J.S., Goessler, W. and Jenkins, R.O. (2004) An origin for arsenobetaine involving bacterial formation of an arsenic-carbon bond. FEMS Microbiology Letters. 235 (1) pp.95-99 ...
https://www.dora.dmu.ac.uk/xmlui/handle/2086/2027
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http://trios.tsukuba.ac.jp/en/researcher/0000003476
Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines<...Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines<...
TY - JOUR. T1 - Arsenic trioxide-induced apoptosis through oxidative stress in cells of colon cancer cell lines. AU - Nakagawa, Yoshihito. AU - Akao, Yukihiro. AU - Morikawa, Hiroshi. AU - Hirata, Ichiro. AU - Katsu, Kenichi. AU - Naoe, Tomoki. AU - Ohishi, Nobuko. AU - Yagi, Kunio. N1 - Funding Information: The DLD-1 and COLO201 colon cancer cell lines used in this study were kindly supplied by the Health Science Research Resources Bank of the Japan Health Sciences Foundation. This work was supported in part by a Grant-in-Aid for Scientific Research by the Ministry of Education, Science, Sports and Culture of Japan.. PY - 2002/3/29. Y1 - 2002/3/29. N2 - Exposure of three colon cancer cell lines, SW480, DLD-1, and COLO201, to arsenic trioxide in the medium induced a marked concentration-dependent suppression of cell growth. The intracellular contents of reduced glutathione (GSH) in these cell lines tended to be inversely correlated with the sensitivity of the cells to arsenic trioxide. Among the ...
https://pure.fujita-hu.ac.jp/en/publications/arsenic-trioxide-induced-apoptosis-through-oxidative-stress-in-ce
Gallium Arsenide Market Overview, Scope And Chemical Research 2018 | Trade CallsGallium Arsenide Market Overview, Scope And Chemical Research 2018 | Trade Calls
There are 15 Chapters to deeply display the Global Gallium Arsenide market.. Chapter 1, to describe Gallium Arsenide Introduction, product scope, market overview, market opportunities, market risk, market driving force;. Chapter 2, to analyze the top manufacturers of Gallium Arsenide, with sales, revenue, and price of Gallium Arsenide, in 2016 and 2018;. Chapter 3, to display the competitive situation among the top manufacturers, with sales, revenue and market share in 2016 and 2018;. Chapter 4, to show the Global market by regions, with sales, revenue and market share of Gallium Arsenide, for each region, from 2012 to 2018;. Chapter 5, 6, 7, 8 and 9, to analyze the key regions, with sales, revenue and market share by key countries in these regions;. Chapter 10 and 11, to show the market by type and application, with sales market share and growth rate by type, application, from 2012 to 2018;. Chapter 12, Gallium Arsenide market forecast, by regions, type and application, with sales and revenue, ...
http://www.tradecalls.org/2018-02-09-gallium-arsenide-market
Arsenic trioxide: Its use in the treatment of acute promyelocytic leukemia<...
TY - JOUR. T1 - Arsenic trioxide. T2 - Its use in the treatment of acute promyelocytic leukemia. AU - Sanz, Miguel A.. AU - Lo-Coco, Francesco. PY - 2006. Y1 - 2006. N2 - Acute promyelocytic leukemia (APL) represents approximately 10-15% of all adult cases of acute myeloid leukemia and is characterized by a unique genetic abnormality and frequent association with a severe hemorrhagic diathesis. An arsenic trioxide formulation for intravenous infusion has been developed and is currently licensed for the induction of remission and consolidation in adult patients with relapsed/refractory APL. Several studies have shown that arsenic trioxide is highly effective in the treatment of relapsed/refractory patients with APL, achieving remission rates of ,80%, high rates of molecular remission, and durable periods of disease-free survival. Furthermore, recent studies indicate that arsenic trioxide may also have a role in the treatment of newly diagnosed patients, either as a single agent or in combination ...
https://moh-it.pure.elsevier.com/en/publications/arsenic-trioxide-its-use-in-the-treatment-of-acute-promyelocytic-
Arsenides Exporter, Manufacturer, Distributor, Supplier, Trading Company, Arsenides India
TRIVENI INTERCHEM PVT. LTD. - Exporter, Manufacturer, Distributor, Supplier, Trading Company of Arsenides Aluminium arsenide,Aluminium gallium arsenide,Aluminium indium arsenide,Arsenide,Boron arsenide,Cadmium arsenide,Gallium arsenide,Gallium arsenide phosphide,Gallium manganese arsenide, India
http://www.triveniinterchem.in/arsenides.html
Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients With Acute Myeloid Leukemia - Tabular...Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients With Acute Myeloid Leukemia - Tabular...
Cycle 1 cytarabine 10 mg/m^2 was administered subcutaneously (sc) twice daily (bid) on days 1-14. 0.25 mg/kg arsenic trioxide was administered intravenously (iv) on days 1-5 and days 8-12. Cycle 2 A second identical cycle of cytarabine and arsenic trioxide was given to patients with persistent disease. Patients who achieved complete remission (CR), complete remission with incomplete platelet count recovery (CRp), or partial remission (PR) after 1 or 2 cycles received a 14-day consolidation cycle of cytarabine and arsenic trioxide with the doses and schedule identical to the initial cycle. A recovery period of up to 4 weeks between the attainment of CR, CRp, or PR and the initiation of consolidation treatment was allowed. Patients who completed consolidation treatment started maintenance treatment of arsenic trioxide 0.25 mg/kg iv on days 1 and 4 and cytarabine 10 mg/m^2 sc bid on days 1 through 7 of a 28-day cycle ...
https://clinicaltrials.gov/ct2/show/record/NCT00513305
Study of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic LeukemiaStudy of NRX 195183 Therapy for Patients With Relapsed or Refractory Acute Promyelocytic Leukemia
The purpose of this study is to determine whether NRX 195183 is effective in the treatment of relapsed or refractory Acute Promyelocytic Leukemia
http://www.knowcancer.com/cancer-trials/NCT00675870/
Study of Arsenic Trioxide in Small Cell Lung Cancer - Full Text View - ClinicalTrials.govStudy of Arsenic Trioxide in Small Cell Lung Cancer - Full Text View - ClinicalTrials.gov
The purpose of this study is to study the effect of an anticancer drug, Arsenic Trioxide, in patients with small cell lung cancer who have failed at least one standard chemotherapy regimen as well as patients who are unable to tolerate the standard treatment for their cancer. The investigators seek to establish the safety of and efficacy of Arsenic Trioxide in this patient group. The study will include up to 36 participants with small cell lung cancer.. The investigators want to find out what effects, good or bad, that the study drug has on your cancer. This study will also look at specific biomarkers in your blood and in the tumor tissue which may help the investigators to determine if the levels of these biomarkers are related to tumor response to treatment.. Arsenic Trioxide, also known by the brand name, Trisenox, is a chemotherapy drug approved by the Food and Drug Administration (FDA) for the treatment of a specific type of blood cancer called Acute Promyelocytic Leukemia. It works in part ...
https://clinicaltrials.gov/ct2/show/NCT01470248?recr=Open&cond=%22Lung+Neoplasms%22&rank=12
Arsenic Trioxide - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWikiArsenic Trioxide - Side Effects, Uses, Dosage, Overdose, Pregnancy, Alcohol | RxWiki
Arsenic Trioxide - Get up-to-date information on Arsenic Trioxide side effects, uses, dosage, overdose, pregnancy, alcohol and more. Learn more about Arsenic Trioxide
https://www.rxwiki.com/arsenic-trioxide
ARSENIC TRIOXIDE (ARSENITE)
Arsenic is a highly poisonous metallic element in the nitrogen family of group Va in the periodic table. Symbol As; aomic number 33; atomic mass 74.9216; melting point ca 817°C; sublimation point ca 613°C; specific gravity 6.80 or 7.004; 5.73; valence -3, 0, +3, or +5.; electronic config. [Ar]3d104s24p3. It appears in three allotropic forms, yellow, black, and gray. The stable form is a brittle, steel-gray hexagonal solid that oxidizes rapidly in air, and at high temperatures burns to form a white cloud of arsenic trioxide. Arsenic and some arsenic compounds sublime when heated and convert to gaseous form. Arsenic is an omnipresent element as arsenic minerals in the various lithosphere or fossil fuels including realgar, orpiment, and arsenopyrite. It is prepared commercially from arsenical pyrites (sulfide ores) by condensation of sublimed gas and by the reduction of white arsenic with carbon. This element contributes hardness and is used in preparing alloys for hard and corrosion-resistant ...
http://www.chemicalland21.com/industrialchem/inorganic/ARSENIC%20TRIOXIDE.htm
Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...
JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia
http://www.tevapharm.com/news/teva_announces_u_s_fda_approval_of_trisenox_arsenic_trioxide_injection_for_first_line_treatment_of_acute_promyelocytic_leukemia_01_18.aspx
Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic...
JERUSALEM--(BUSINESS WIRE)--Jan. 15, 2018-- Teva Pharmaceutical Industries Ltd. (NYSE and TASE: TEVA) announced that the U.S. Food and Drug Admini, Teva Announces U.S. FDA Approval of TRISENOX® (arsenic trioxide) Injection for First Line Treatment of Acute Promyelocytic Leukemia
http://tevapharm.com/news/teva_announces_u_s_fda_approval_of_trisenox_arsenic_trioxide_injection_for_first_line_treatment_of_acute_promyelocytic_leukemia_01_18.aspx
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive...
Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism. Benjamin D. Bowling, Nicole Doudican, Prashiela Manga, and Seth J. Orlow, Department of Dermatology, NYU School of Medicine, New York City, New York. (Sponsored by David J. Leffell, Department of Dermatology, Yale University School of Medicine). Current standard chemotherapeutic regimens for malignant melanoma are unsatisfactory. Although in vitro studies of arsenic trioxide (ATO) have demonstrated promise against melanoma, recent phase II clinical trials have failed to show any significant clinical benefit when used as a single agent. To enhance the efficacy of ATO in the treatment of melanoma, we sought to identify compounds that potentiate the cytotoxic effects of ATO in melanoma cells. Through a screen of 2000 marketed drugs and naturally occurring compounds, and subsequent mechanistic testing, a variety of antibiotic inhibitors of ...
http://www.openthesis.org/documents/Inhibition-mitochondrial-protein-translation-sensitizes-368893.html
arsenic trioxide Intravenous - patient information, description, dosage and directions.arsenic trioxide Intravenous - patient information, description, dosage and directions.
Description of the drug arsenic trioxide Intravenous. - patient information, description, dosage and directions. What is arsenic trioxide Intravenous!
http://drugster.info/drug/medicament/2141/
Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk...Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk...
Teva Receives FDA Priority Review for First Line Use of TRISENOX® (arsenic trioxide) in Patients with Low to Intermediate Risk Acute Promyelocytic Leukemia (APL)
http://www.tmcnet.com/usubmit/2017/09/12/8610048.htm
Trisenox (Arsenic Trioxide Injection): Side Effects, Interactions, Warning, Dosage & UsesTrisenox (Arsenic Trioxide Injection): Side Effects, Interactions, Warning, Dosage & Uses
Learn about Trisenox (Arsenic Trioxide Injection) may treat, uses, dosage, side effects, drug interactions, warnings, patient labeling, reviews, and related medications.
https://www.rxlist.com/trisenox-drug.htm
Evaluation of Arsenic Trioxide Potential for Lung Cancer Treatment: ASSessment of Apoptotic Mechanisms and Oxidative Damage -...Evaluation of Arsenic Trioxide Potential for Lung Cancer Treatment: ASSessment of Apoptotic Mechanisms and Oxidative Damage -...
Abstract: Background: Lung cancer is one of the most lethal and common cancers in the world, causing up to 3 million deaths annually. The chemotherapeutic drugs that have been used in treating lung cancer include cisplatinpemetrexed, cisplastin-gencitabinoe, carboplatin-pacitaxel and crizotinib. Arsenic trioxide (ATO) has been used in the treatment of acute promyelocytic leukemia. However, its effects on lung cancer are not known. We hypothesize that ATO may also have a bioactivity against lung cancer, and its mechanisms of action may involve apoptosis, DNA damage and changes in stress-related proteins in lung cancer cells. Methods: To test the above stated hypothesis, lung carcinoma (A549) cells were used as the test model. The effects of ATO were examined by performing 6-diamidine-2 phenylindole (DAPI) nuclear staining for morphological characterization of apoptosis, flow cytometry analysis for early apoptosis, and western blot analysis for stressrelated proteins (Hsp70 and cfos) and apoptotic ...
https://dlg.usg.edu/record/auu_cau-ir_2016-walker-alice-m
Arsenic trioxide - An old drug re... preview & related info | MendeleyArsenic trioxide - An old drug re... preview & related info | Mendeley
(2010) A., S.D.. Blood Reviews. Over the last 17years, clinical trials conducted worldwide have demonstrated the efficacy of arsenic trioxide (As2O3) in the treatment of relapsed acute promyelocytic leukemia (APL). Currently, the role of As2O3 in front-line therapy is under investigation. Recent ...
https://www.mendeley.com/catalogue/arsenic-trioxide-old-drug-rediscovered-1/
PRIME PubMed | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined...PRIME PubMed | Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined...
PubMed journal article: Arsenic Trioxide, Itraconazole, All-Trans Retinoic Acid and Nicotinamide: A Proof of Concept for Combined Treatments with Hedgehog Inhibitors in Advanced Basal Cell Carcinoma. Download Prime PubMed App to iPhone, iPad, or Android
https://www.unboundmedicine.com/medline/citation/32545245/Arsenic_Trioxide,_Itraconazole,_All-Trans_Retinoic_Acid_and_Nicotinamide:_A_Proof_of_Concept_for_Combined_Treatments_with_Hedgehog_Inhibitors_in_Advanced_Basal_Cell_Carcinoma
OBSERVATION OF DARK LINE DEGRADATION SITES IN ALUMINUM GALLIUM ARSENIDE GALLIUM ARSENIDE DH LASER MATERIAL BY ETCHING AND PHASE...OBSERVATION OF DARK LINE DEGRADATION SITES IN ALUMINUM GALLIUM ARSENIDE GALLIUM ARSENIDE DH LASER MATERIAL BY ETCHING AND PHASE...
Nokia sites use cookies to improve and personalize your experience and to display advertisements. The sites may also include cookies from third parties. By using this site, you consent to the use of cookies. Learn more ...
https://www.bell-labs.com/institute/publications/bl7490721/
Arsenic trioxide in ovarian cancer | ScholarBank@NUSArsenic trioxide in ovarian cancer | [email protected]
Arsenic trioxide (As2O3) has shown anti-tumour activity against a variety of solid tumours in vitro. However, the mechanisms responsible for its cytotoxicity against ovarian carcinoma remain elusive. In this thesis, the molecular determinants of its effects and factors mediating its chemoresistance in ovarian cancer cells were investigated. It was found that As2O3 treatment caused both apoptosis induction and caspase-independent cell death involving mitochondrial dysfunction. This was accompanied by endoplasmic reticulum stress induction and an increase in intracellular glutathione (GSH) level. The latter was in turn prevented by the concurrent use of GSH modulator, buthionine sulfoximine but not ascorbic acid. Gene expression analysis of arsenic-resistant OVCAR-3 (OVCAR-3/AsR) cells showed the involvement of multiple factors mediating its chemoresistance. Of particular interest, a genetic hub involving elevated interleukin 1A signalling was identified. This could consecutively modulate the ...
http://scholarbank.nus.edu.sg/handle/10635/28135
Arsenic trioxide in the mechanism of drug resistance reversal in MCF-7/ADM cell line of human breast cancer.
OBJECTIVE: To investigate the effect of drug resistance by arsenic trioxide (As(2)O(3)) and its possible mechanism in human breast cancer cell line MCF-7/ADM. METHODS: Cytotoxicity of As(2)O(3) and the sensibility to adriamycin (ADM) in MCF-7/ADM cel
http://www.biomedsearch.com/nih/Arsenic-trioxide-in-mechanism-drug/12408759.html
Figure 4 | Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung...Figure 4 | Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung...
Figure 4: Arsenic Trioxide Suppresses Tumor Growth through Antiangiogenesis via Notch Signaling Blockade in Small-Cell Lung Cancer
https://www.hindawi.com/journals/bmri/2019/4647252/fig4/
Clinical Trial | Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been...Clinical Trial | Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been...
Arsenic Trioxide, Temozolomide, and Radiation Therapy in Treating Patients With Malignant Glioma That Has Been Removed By Surgery This study is currently…
http://comparetrials.com/compare-clinical-trials/arsenic-trioxide-temozolomide-and-radiation-therapy-in-treating-patients-with-malignant-glioma-that-has-been-removed-by-surgery-2
Arsenic Trioxide - Manufacturer,Supplier,ExporterArsenic Trioxide - Manufacturer,Supplier,Exporter
AMBICA PHARMA - Manufacturer,Supplier,Exporter of Arsenic Trioxide from India. We offer best quality of products at a best price rate.
http://www.ambpharmaceutical.com/arsenic-trioxide-3738329.html
Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans:...Association of arsenobetaine with beta-cell function assessed by homeostasis model assessment (HOMA) in nondiabetic Koreans:...
This epidemiological study investigated the association between β-cell function (a predictive factor of diabetes development) and the organic arsenic arsenobetaine (an agent less toxic to humans). Urine arsenobetaine was revealed to be associated with HOMA-β in the normal population (without diabetes), especially in males, even after adjusting for factors affecting diabetes and β-cell function, while no association was shown with HOMA-IR which is associated with insulin resistance.. Despite several conflicting results, arsenic has been reported to be correlated with diabetes in many epidemiological studies [6, 9, 23-31], and arsenic can affect insulin resistance and β-cell function [7]. In some experimental studies, arsenite was found to induce oxidative stress in pancreatic β-cells and reduce insulin transcription and secretion [32, 33], caused by the altered expression of essential genes such as the Pdx1 gene [34, 35] and insulin gene [36] for pancreas development, insulin production, and ...
https://aoemj.biomedcentral.com/articles/10.1186/s40557-017-0181-0
Effective treatment for rare leukemiaEffective treatment for rare leukemia
Adult patients who received the chemotherapy drug arsenic trioxide (Trisenox) immediately after standard chemotherapy had a significantly higher remission rate and better overall survival than those who received standard chemotherapy, according results of a phase III cancer clinical trial for an uncommon form of leukemia.. Seventy-seven percent of adult patients with acute promyelocytic leukemia who received arsenic trioxide remained alive and in remission, free of relapse, three years after diagnosis. This compared with 59 percent on the standard treatment. The greater effectiveness of the experimental combination also resulted in better overall survival of 86 percent after three years for the patients who received the arsenic trioxide compared to 77 percent for patients on the standard treatment arm.. Dr. Fred Appelbaum, director of the Centers Clinical Research Division, helped conceive, write the protocol, enroll patients and write up the results for the NCI-sponsored trial.. Acute ...
https://www.fredhutch.org/en/news/center-news/2007/02/effective-treatment-for-rare-leukemia.html
Steady-State and Transient Electron Transport within Bulk InAs, InP and GaAs: An Updated Semiclassical Three-Valley Monte Carlo...Steady-State and Transient Electron Transport within Bulk InAs, InP and GaAs: An Updated Semiclassical Three-Valley Monte Carlo...
An ensemble Monte Carlosimulation is used to compare high field electron transport in bulk InAs, InP and GaAs. In particular, velocity overshoot and electron transit times are examined. For all materials, we find that electron velocity overshoot only occurs when the electric field is increased to a value above a certain critical field, unique to each material. This critical field is strongly dependent on the material, about 3 kV/cm for InAs, 10 kV/cm for InP and 5 kV/cm for the case of GaAs, We find that InAs exhibits the highest peak overshoot velocity and that this velocity overshoot lasts over the longest distances when compared with GaAs and InP. Finally, we estimate the minimum transit time across a 1 μm InAs sample to be about 2 ps. Similar calculations for InP and GaAs yield 6.6 and 5.4 ps, respectively. We find that the optimal cutoff frequency for an ideal InAs based device ranges from around 79 GHz when the device thickness is set to 1 μm. We thus suggest that indium arsenide offers great
https://www.scirp.org/journal/paperinformation.aspx?paperid=31606
Radioprotection and Cell Cycle Arrest of Intestinal Epithelial Cells by Darinaparsin, a Tumor Radiosensitizer (Journal Article)...Radioprotection and Cell Cycle Arrest of Intestinal Epithelial Cells by Darinaparsin, a Tumor Radiosensitizer (Journal Article)...
Purpose: It was recently reported that the organic arsenic compound darinaparsin (DPS) is a cytotoxin and radiosensitizer of tumor cells in vitro and in subcutaneous xenograft tumors. Surprisingly, it was also found that DPS protects normal intestinal crypt epithelial cells (CECs) from clonogenic death after ionizing radiation (IR). Here we tested the DPS radiosensitizing effect in a clinically relevant model of prostate cancer and explored the radioprotective effect and mechanism of DPS on CECs. Methods and Materials: The radiation modification effect of DPS was tested in a mouse model of orthotopic xenograft prostate cancer and of IR-induced acute gastrointestinal syndrome. The effect of DPS on CEC DNA damage and DNA damage responses was determined by immunohistochemistry. Results: In the mouse model of IR-induced gastrointestinal syndrome, DPS treatment before IR accelerated recovery from body weight loss and increased animal survival. DPS decreased post-IR DNA damage and cell death, ...
https://www.osti.gov/scitech/biblio/22278306-radioprotection-cell-cycle-arrest-intestinal-epithelial-cells-darinaparsin-tumor-radiosensitizer
Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for phase I clinical trial<...Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for phase I clinical trial<...
TY - JOUR. T1 - Pharmaceutical development of the novel arsenical based cancer therapeutic GSAO for phase I clinical trial. AU - Elliott, Moira. AU - Ford, S J. AU - Prasad, E. AU - Dick, L J. AU - Farmer, H. AU - Hogg, P J. AU - Halbert, G W. N1 - Copyright © 2012 Elsevier B.V. All rights reserved.. PY - 2012/4/15. Y1 - 2012/4/15. N2 - The novel organoarsenical GSAO, 4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid, has potential anti-angiogenic capability with application in cancer where tumour metastasis relies on neo-vascularisation. As GSAO arsenic is trivalent, the arsenoxide moiety reacts with appropriately spaced cysteine residues on adenine nucleotide translocase (ANT) mitochondrial membrane protein. Molecular oxidation of the arsenic to the pentavalent structure, as in the degradant GSAA (4-(N-(S-glutathionylacetyl)amino) phenylarsonic acid), prevents sulphydryl interaction and risks abolition of activity. We report here on formulation studies aiming to produce a parenteral ...
https://pureportal.strath.ac.uk/en/publications/pharmaceutical-development-of-the-novel-arsenical-based-cancer-th
ATRA-arsenic new standard of care for APL - PM360ATRA-arsenic new standard of care for APL - PM360
FROM JOURNAL OF CLINICAL ONCOLOGY. The combination of all-trans--retinoic acid (ATRA) and arsenic trioxide continues to show advantages over ATRA and chemotherapy as first-line therapy for patients with low- or intermediate-risk acute promyelocytic leukemia (APL), investigators report.. The final analysis of the APL046 study , a noninferiority trial of ATRA plus arsenic trioxide (ATRA-ATO) vs. ATRA and standard chemotherapy, showed that event-free survival (EFS) and overall survival (OS) were significantly better among patients assigned to ATRA-ATO. Patients in this group also had a significantly lower cumulative incidence of relapse, reported Francesco Lo-Coco, MD, of University Tor Vergata in Rome and colleagues.. Our results support the use of ATRA-ATO in patients with newly diagnosed APL and point to this strategy as the new standard of care for low- or intermediate-risk patients. Studies exploring the role of ATRA-ATO are warranted in other APL subsets including high-risk, pediatric, and ...
https://www.pm360online.com/atra-arsenic-new-standard-of-care-for-apl/
Background Lung tumor is among the most lethal and common malignancies - HDAC Inhibition for the Disruption of Latent HIV-1...Background Lung tumor is among the most lethal and common malignancies - HDAC Inhibition for the Disruption of Latent HIV-1...
Background Lung tumor is among the most lethal and common malignancies in the world leading to up to 3 million fatalities annually. for morphological characterization of apoptosis movement cytometry evaluation for early apoptosis and traditional western blot evaluation for stress-related protein (Hsp70 and cfos) and apoptotic proteins expressions. Also the one cell gel electrophoresis (Comet) assay was utilized to judge the genotoxic impact. Outcomes ATO-induced apoptosis was evidenced by chromatin condensation and formation of apoptotic bodies as revealed by DAPI nuclear staining. Cell shrinkage and membrane blebbing were Neratinib observed at 4 and 6 μg/ml of ATO. Data from the western blot analysis revealed a significant dose-dependent increase (p < 0.05) in the Hsp 70 caspase 3 and p53 protein expression and a significant (p < 0.05) decrease in the cfos and bcl-2 protein expression at 4 and 6 μg/ml of ATO. There was a slight decrease in cytochrome c protein expression at 4 and 6 μg/ ml of ...
https://recyclers-info.com/background-lung-tumor-is-among-the-most-lethal-and-common-malignancies/
Legal Notice | TRISENOX® (arsenic trioxide) injection
Teva Pharmaceuticals USA, Inc. and its North American affiliates maintain this site for your personal information, education, and communication.
https://www.trisenox.com/legal-notice/
Arsenic Compounds Effective Against APL | Cancer Network | The Oncology JournalArsenic Compounds Effective Against APL | Cancer Network | The Oncology Journal
NEW ORLEANS-Two forms of arsenic are effective for inducing remissions in people with acute promyelocytic leukemia (APL), according to data presented at the ASH meeting. 1
http://www.cancernetwork.com/articles/arsenic-compounds-effective-against-apl
Organometallic vapor-phase homoepitaxy of gallium arsenide assisted by a downstream hydrogen
Hydrogen passivation of Si δ-doped GaAs grown by molecular beam epitaxy. Swaminathan, V.; Asom, M. T.; Livescu, G.; Geva, M.; Stevie, F. A.; Pearton, S. J.; Lopata, J. // Applied Physics Letters;12/31/1990, Vol. 57 Issue 27, p2928 Hydrogen passivation of Si δ-doped GaAs grown by molecular beam epitaxy is studied. Just as in uniformily Si-doped GaAs, exposure of the δ-doped material to a low frequency (30 kHz) hydrogen plasma at 250 °C for 30 min deactivates the Si donors in the δ spikes. For samples with Si... ...
http://connection.ebscohost.com/c/articles/4250552/organometallic-vapor-phase-homoepitaxy-gallium-arsenide-assisted-by-downstream-hydrogen
The action of phenylarsine oxide on insulin stimulation of glucose transport in rat adipocytes | Biochemical Society...The action of phenylarsine oxide on insulin stimulation of glucose transport in rat adipocytes | Biochemical Society...
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://www.biochemsoctrans.org/content/14/2/313
Inorganic Arsenicals (Toxicity) - Toxicology - Merck Veterinary ManualInorganic Arsenicals (Toxicity) - Toxicology - Merck Veterinary Manual
Learn about the veterinary topic of Inorganic Arsenicals (Toxicity). Find specific details on this topic and related topics from the Merck Vet Manual.
https://www.merckvetmanual.com/toxicology/arsenic-poisoning/inorganic-arsenicals-toxicity
STRIPED GALLIUM ARSENIDE LASERS: MODE SIZE AND EFFICIENCY. - Nokia Bell LabsSTRIPED GALLIUM ARSENIDE LASERS: MODE SIZE AND EFFICIENCY. - Nokia Bell Labs
Nokia sites use cookies to improve and personalize your experience and to display advertisements. The sites may also include cookies from third parties. By using this site, you consent to the use of cookies. Learn more ...
http://www.bell-labs.com/institute/publications/bl7591205/
Trisenox Side Effects in Detail - Drugs.comTrisenox Side Effects in Detail - Drugs.com
Learn about the potential side effects of Trisenox (arsenic trioxide). Includes common and rare side effects information for consumers and healthcare professionals.
https://www.drugs.com/sfx/trisenox-side-effects.html
Arsenic Trioxide in Treating Patients With Multiple MyelomaArsenic Trioxide in Treating Patients With Multiple Myeloma
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. PURPOSE: Phase II trial
http://www.knowcancer.com/cancer-trials/NCT00017433/
Arsenic trioxide - toxicity, ecological toxicity and regulatory informationArsenic trioxide - toxicity, ecological toxicity and regulatory information
Data on 6,500 pesticides, insecticides and herbicides including toxicity, water pollution, ecological toxicity, uses and regulatory status.
http://www.pesticideinfo.org/Detail_Chemical.jsp?Rec_Id=PC33821
Background The tumor associated antigen (TAA) gp100 was one of the | Nutlin-3 overcomes arsenic trioxide resistance and tumor...Background The tumor associated antigen (TAA) gp100 was one of the | Nutlin-3 overcomes arsenic trioxide resistance and tumor...
Background The tumor associated antigen (TAA) gp100 was one of the first identified and has been used in clinical trials to treat melanoma patients. also collected as secondary endpoints. Patients that were HLA-A*2402 positive with stage IV melanoma were enrolled according to the criteria set by the protocol and immunized with a vaccine consisting of epitope peptide (VYFFLPDHL, gp100-in4) emulsified with incomplete Freunds adjuvant (IFA) for the total of 4 occasions with two week intervals. Prior to each vaccination, peripheral bloodstream mononuclear cells (PBMCs) had been separated in the blood and kept at -80C. The kept PBMCs had been thawed and analyzed for the regularity from the peptide particular T lymphocytes by IFN- ELISPOT and MHC-Dextramer assays. Outcomes No related undesirable events higher than quality I had been seen in the six sufferers signed up for this research. No clinical replies had been seen in the enrolled sufferers although vitiligo was noticed following the vaccination ...
https://nutlin-3.com/background-the-tumor-associated-antigen-taa-gp100-was-one-of-the/
Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth | OncotargetArsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth | Oncotarget
https://doi.org/10.18632/oncotarget.5836 Wenchao Zhou, Lin Cheng, Yu Shi, Susan Q. Ke, Zhi Huang, Xiaoguang Fang, Cheng-wei Chu, Qi Xie, Xiu-wu Bian, Jeremy N. Rich, Shideng Bao
https://www.oncotarget.com/article/5836/
Most recent papers with the keyword Journal of clinical oncology meta analysis | Read by QxMDMost recent papers with the keyword Journal of clinical oncology meta analysis | Read by QxMD
BACKGROUND: The studies have demonstrated that arsenic trioxide (ATO) in combination with all-trans retinoic acid (ATRA) takes effects in treatment of acute promyelocytic leukemia (APL) through different underlying mechanisms. This has established the molecular foundation of ATO plus ATRA therapy. Currently, ATO plus ATRA has also been widely used in clinical practice. OBJECTIVE: To assess the efficacy and safety of ATO in combination with ATRA for APL. SEARCH STRATEGY: The Cochrane Library (Issue 1, 2009), Cochrane Central Register of Controlled Trials (from 1970 to January 2009), MEDLINE (from 1978 to October 2008), EMBASE (from 1950 to March 2009), Chinese Biological Medical Literature Database (from 1978 to December 2008), CNKI (from 1994 to December 2008), China Medical Academic Conference Database (from 1994 to December 2008) were electronically searched ...
https://www.readbyqxmd.com/keyword/31054
CAS No.1309-64-4,Diantimony trioxide Suppliers,MSDS downloadCAS No.1309-64-4,Diantimony trioxide Suppliers,MSDS download
Find quality suppliers and manufacturers of 1309-64-4(Diantimony trioxide) for price inquiry. where to buy 1309-64-4(Diantimony trioxide).Also offer free database of 1309-64-4(Diantimony trioxide) including MSDS sheet(poisoning, toxicity, hazards and safety),chemical properties,Formula, density and structure, solution etc.
http://www.lookchem.com/cas-130/1309-64-4.html
Ecocentric | The Arsenic in Your ChickenEcocentric | The Arsenic in Your Chicken
Despite the threat to human health and the environment, industrial poultry producers continue to use arsenical drugs to boost growth rates. A new study measured how much of this arsenic ends up in your meat.
http://www.gracelinks.org/blog/2561/the-arsenic-in-your-chicken
ArsenicalArsenical
Arsenicals are chemical compounds that contain arsenic. In a military context, the term arsenical refer to toxic arsenic ... Look up arsenical in Wiktionary, the free dictionary. v t e (Arsenic compounds, Chemical weapons, Poisons, All stub articles, ... "Arsenicals - MeSH - NCBI". Handbook of chemical and biological warfare agents (2nd ed.). CRC Press. 24 August 2007. ISBN ...
https://en.wikipedia.org/wiki/Arsenical
Arsenical copperArsenical copper
Arsenical bronze Arsenical brass Rollason, EC (1949). Metallurgy for Engineers (2nd ed.). London: Arnold. "IBR - 1950 : Reg. ... Arsenical copper contains up to 0.5% arsenic which, at elevated temperatures, imparts higher tensile strength and a reduced ... Copper with a larger percentage of arsenic is called arsenical bronze, which can be work-hardened much harder than copper. ...
https://en.wikipedia.org/wiki/Arsenical_copper
Arsenical bronzeArsenical bronze
Arsenical copper Arsenical brass Charles, J. A. (January 1967). "Early Arsenical Bronzes - A Metallurgical view". American ... Arsenical bronze has seen little use in the modern period. It appears that the closest equivalent goes by the name of arsenical ... saw the use of arsenical bronze. Indeed, it seems that arsenical bronze was the most common alloy in use in the Mediterranean ... to be traded and used to make arsenical bronze elsewhere by addition to molten copper. Artifacts made of arsenical bronze cover ...
https://en.wikipedia.org/wiki/Arsenical_bronze
Arsenical keratosisArsenical keratosis
An arsenical keratosis is a growth of keratin on the skin caused by arsenic,: 725 which occurs naturally in the earth's crust ... Arsenical keratoses may persist indefinitely, and some may develop into invasive squamous cell carcinoma. Metastatic arsenic ... ISBN 0-7216-2921-0. Yerebakan O, Ermis O, Yilmaz E, Basaran E (February 2002). "Treatment of arsenical keratosis and Bowen's ... Topical 5-fluorouracil cream or 5% imiquimod cream may be useful in treating arsenical keratoses and Bowen's disease. Freedberg ...
https://en.wikipedia.org/wiki/Arsenical_keratosis
ArsenicArsenic
"organic arsenicals". EPA. "Trace Elements in Soils and Plants, Third Edition". CRC Press. Archived from the original on 21 ... However, arsenicals such as melarsoprol are still used for the treatment of trypanosomiasis, since although these drugs have ... These organic arsenicals were in turn phased out by 2013 in all agricultural activities except cotton farming. The ... "Phosphorus Deoxidized Arsenical Copper" with an arsenic content of 0.3% has an increased corrosion stability in certain ...
https://en.wikipedia.org/wiki/Arsenic
Lead hydrogen arsenateLead hydrogen arsenate
Inorganic Arsenicals; Intent to Cancel Registrations for Pesticide Products Registered for Non-Wood Preservative Use; ... Herrick, Glenn Washington (1910). "The Snow-white Linden Moth". Historic Arsenical Pesticide Research (PDF) (Report). US ... Lead arsenate was the most extensively used arsenical insecticide. Two principal formulations of lead arsenate were marketed: ...
https://en.wikipedia.org/wiki/Lead_hydrogen_arsenate
ArsineArsine
Suchard, Jeffrey R. (March 2006). "CBRNE - Arsenicals, Arsine". EMedicine. Archived from the original on 2006-06-23. Retrieved ...
https://en.wikipedia.org/wiki/Arsine
Colin RastonColin Raston
... the arsenical constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in metabolism of arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Högberg, A. G. S. ( ...
https://en.wikipedia.org/wiki/Colin_Raston
ArsenobetaineArsenobetaine
... the Arsenical Constituent of the Western Rock Lobster Panulirus longipes cygnus George". Tetrahedron Letters. 18 (18): 1543- ... "Commonalities in Metabolism of Arsenicals". Environmental Chemistry. 2 (3): 161-166. doi:10.1071/EN05054. Ng, J. C. (2005). " ...
https://en.wikipedia.org/wiki/Arsenobetaine
November 1900November 1900
"Arsenical Beer". The Times. London. February 13, 1901. p. 9. "Twelve-Inch Gun a Wonder". The New York Times. November 16, 1900 ...
https://en.wikipedia.org/wiki/November_1900
Cacodyl cyanideCacodyl cyanide
Organic Arsenical Compounds. 1923. "Scientific Worthies" (PDF). 28 April 1881. Archived (PDF) from the original on 2021-12-12. ... Seyferth D (2001). "Cadet's Fuming Arsenical Liquid and the Cacodyl Compounds of Bunsen". Organometallics. 20 (8): 1488-1498. ...
https://en.wikipedia.org/wiki/Cacodyl_cyanide
Otto NeubauerOtto Neubauer
Neubauer, O (1947). "Arsenical Cancer: A Review". British Journal of Cancer. 1 (2): 192-251. doi:10.1038/bjc.1947.22. ISSN 0007 ...
https://en.wikipedia.org/wiki/Otto_Neubauer
Arsenic biochemistryArsenic biochemistry
Lin, Lin S.; Thomas, D. J.; Cullen, W. R.; Wang, C.; Styblo, M.; Del Razo, L. M. (2001). "Arsenicals inhibit thioredoxin ... Chouchane, S.; Snow, E. T.; Snow, E. T. (2001). "In vitro effect of arsenical compounds on glutathione-related enzymes". Chem. ... Kitchin, K.T; Wallace, K (2008). "Evidence against the nuclear in situ binding of arsenicals-Oxidative stress theory of arsenic ... Nesnow, S; Roop, B.C (2002). "DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species". ...
https://en.wikipedia.org/wiki/Arsenic_biochemistry
P-AzobenzenearsonateP-Azobenzenearsonate
... is an arsenical. It causes antibody formation and delayed hypersensitivity when bound to aromatic amino ...
https://en.wikipedia.org/wiki/P-Azobenzenearsonate
Karasuk cultureKarasuk culture
Arsenical bronze artefacts are present. Their settlements were of pit houses and they buried their dead in stone cists covered ...
https://en.wikipedia.org/wiki/Karasuk_culture
Leeds City MuseumLeeds City Museum
Chestofbooks.com webpage: Arsenical soap. Chrystal, Paul (2016). Leeds in 50 Buildings: 9. Leeds City Museum 1819 Park Row. ... as the Victorians will have preserved it with arsenical soap. For over a century it has sagged somewhat, as can be seen in the ...
https://en.wikipedia.org/wiki/Leeds_City_Museum
Imperial Oil (Superfund site)Imperial Oil (Superfund site)
One, which reprocessed waste oil, may have discharged wastes to a nearby stream; another company produced arsenical pesticides ...
https://en.wikipedia.org/wiki/Imperial_Oil_(Superfund_site)
Georges-Simon SerullasGeorges-Simon Serullas
Antimoine arsenical dans le commerce. Metz, Antoine, September 1820. Second mémoire sur les alliages du potassium et sur ...
https://en.wikipedia.org/wiki/Georges-Simon_Serullas
Monosodium methyl arsonateMonosodium methyl arsonate
"Organic Arsenical Products Task Force". National Library of Medicine. "Sodium Methanearsonate". HSDB Database. Specific ...
https://en.wikipedia.org/wiki/Monosodium_methyl_arsonate
Potassium arsenitePotassium arsenite
ISBN 0-8493-0474-1. Jolliffe, D. M. (1993). "The history of the use of arsenicals in man". Journal of the Royal Society of ...
https://en.wikipedia.org/wiki/Potassium_arsenite
MethyldichloroarsineMethyldichloroarsine
Fitzgerald GM, Vollmer T (2006-06-19). "CBRNE - Vesicants, Organic Arsenicals: L, ED, MD, PD, HL". WebMD. Retrieved 2008-12-23 ... Arsenical vesicants, Organoarsenic chlorides, World War I chemical weapons, Arsenic(III) compounds). ...
https://en.wikipedia.org/wiki/Methyldichloroarsine
PhenyldichloroarsinePhenyldichloroarsine
... is an arsenical vesicant which can be mixed with mustard agents for use in chemical warfare. PD was ... Phenyldichloroarsine, also known by its wartime name phenyl Dick and its NATO abbreviation PD, is an organic arsenical vesicant ... Fitzgerald GM, Vollmer T (19 June 2006). "CBRNE - Vesicants, Organic Arsenicals: L, ED, MD, PD, HL". emedicine. WebMD. ... Phenyldichloroarsine is one of four organic arsenicals, the other three are lewisite (L), methyldichloroarsine (MD), and ...
https://en.wikipedia.org/wiki/Phenyldichloroarsine
Arsanilic acidArsanilic acid
Since at least 2000 BC, arsenic and inorganic arsenical compounds were both medicine and poison. In the 19th century, inorganic ... In the late 1940s, Salvarsan was replaced in most regions by penicillin, yet organic arsenicals remained in use for ... For poultry and swine, arsanilic acid was among four arsenical veterinary drugs, along with carbarsone, nitarsone, roxarsone, ... the first organic arsenical drug. In 1905, in Britain, H W Thomas and A Breinl reported successful treatment of trypanosomiasis ...
https://en.wikipedia.org/wiki/Arsanilic_acid
List of patent medicinesList of patent medicines
Fowler's solution: an arsenical compound sold in the 19th century for various ailments including treatment of leukemia. ... Jolliffe, D. M. (1993). "A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289 ...
https://en.wikipedia.org/wiki/List_of_patent_medicines
ArseniteArsenite
"A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289. PMC 1294007. PMID ...
https://en.wikipedia.org/wiki/Arsenite
Fowlers solutionFowler's solution
From 1905, inorganic arsenicals like Fowler's solution saw diminished use as attention turned to organic arsenicals, starting ... As arsenical compounds are notably toxic and carcinogenic-with side effects such as cirrhosis of the liver, idiopathic portal ... "A history of the use of arsenicals in man". Journal of the Royal Society of Medicine. 86 (5): 287-289. doi:10.1177/ ...
https://en.wikipedia.org/wiki/Fowler's_solution
Hal Dixon (biochemist)Hal Dixon (biochemist)
Webster, D.; Sparkes, M. J.; Dixon, H B F. (1978). "An arsenical analogue of adenosine diphosphate". Biochemical Journal. 169 ( ...
https://en.wikipedia.org/wiki/Hal_Dixon_(biochemist)
Black Widows of LiverpoolBlack Widows of Liverpool
An Arsenical Solution of Fly Papers.- Unexampled Cruelty". Vol. I, no. 16. Te Aroha News. 19 April 1884. p. 5. Retrieved 7 May ...
https://en.wikipedia.org/wiki/Black_Widows_of_Liverpool
RealgarRealgar
Jie Liu; Yuanfu Lu; Qin Wu; Robert A. Goyer; Michael P. Waalkes (August 2008). "Mineral arsenicals in traditional medicines: ...
https://en.wikipedia.org/wiki/Realgar
Toroku arsenic diseaseToroku arsenic disease
"Chronic arsenical poisoning due to environmental pollution. Seven cases among inhabitants near an abandoned mine." (1976). ...
https://en.wikipedia.org/wiki/Toroku_arsenic_disease
Browsing by Subject ArsenicalsBrowsing by Subject "Arsenicals"
Gomez-Caminero, A; Howe, Paul D; Hughes, M; Kenyon, E; Lewis, D. R; Moore, M; Aitio, A; Becking, George C; Ng, J; International Programme on Chemical Safety; WHO Task Group on Environmental Health Criteria for Arsenic and Arsenic Compounds (‎World Health OrganizationWorld Health Organization, 2001)‎ ...
https://extranet.who.int/iris/restricted/browse?authority=Arsenicals&type=mesh
CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Clinical Presentation: History, Physical ExaminationCBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Clinical Presentation: History, Physical Examination
The 4 organic arsenicals are lewisite (L), methyldichloroarsine (MD), phenyldichloroarsine (PD), and ethyldichloroarsine (ED). ... Organic arsenicals cause immediate signs, whereas signs of mustard exposure appear after a latent period of several hours. ... CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Clinical Presentation. Updated: Mar 30, 2022 ... Physical signs of organic arsenical exposure are similar to those of mustard agents. The major difference is the time of onset ...
https://emedicine.medscape.com/article/832158-clinical
RCSB PDB - 3F6V: Crystal structure of Possible transcriptional regulator for arsenical resistanceRCSB PDB - 3F6V: Crystal structure of Possible transcriptional regulator for arsenical resistance
Crystal structure of Possible transcriptional regulator for arsenical resistance ... Crystal structure of Possible transcriptional regulator for arsenical resistance from Rhodococcus sp.. Chang, C., Xu, X., Zheng ... Crystal structure of Possible transcriptional regulator for arsenical resistance. *PDB DOI: 10.2210/pdb3F6V/pdb ...
https://www.rcsb.org/structure/3f6v
NIOSHTIC-2 Publications Search - 10005109 - Calcium Chloride-oxygen Leaching and Metals Recovery from an Arsenical Copper...NIOSHTIC-2 Publications Search - 10005109 - Calcium Chloride-oxygen Leaching and Metals Recovery from an Arsenical Copper...
A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by ... A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by ... Calcium Chloride-oxygen Leaching and Metals Recovery from an Arsenical Copper-cobalt Concentrate.. ...
https://www.cdc.gov/niosh/nioshtic-2/10005109.html
Bulletin: Number 695: Non-Arsenical Dusts for Cauliflower and Cabbage Worm Control on Long IslandBulletin: Number 695: Non-Arsenical Dusts for Cauliflower and Cabbage Worm Control on Long Island
Non-Arsenical Dusts for Cauliflower and Cabbage Worm Control on Long Island* (Huckett, Hugh C.) 56 pages. ... Bulletin: Number 695: Non-Arsenical Dusts for Cauliflower and Cabbage Worm Control on Long Island. ...
https://ecommons.cornell.edu/handle/1813/4371
Differential activation of AP‐1 in human bladder epithelial cells by inorganic and methylated arsenicalsDifferential activation of AP‐1 in human bladder epithelial cells by inorganic and methylated arsenicals
... , The FASEB Journal, ... Differential activation of AP‐1 in human bladder epithelial cells by inorganic and methylated arsenicals. ...
https://www.growkudos.com/publications/10.1096%25252Ffj.02-0287fje/reader
Results of search for 'su:{Arsenicals}' › WHO HQ Library catalog
Arsenic and arsenic compounds. by Gomez-Caminero, A , Howe, Paul D , Hughes, M , Kenyon, E , Lewis, D. R , Moore, M , Aitio, A , Becking, George C , Ng, J , International Programme on Chemical Safety , WHO Task Group on Environmental Health Criteria for Arsenic and Arsenic Compounds.. Series: Environmental health criteria ; 224Material type: ...
https://kohahq.searo.who.int/cgi-bin/koha/opac-search.pl?q=su:%7BArsenicals%7D
Insects in the City: Arsenical Herbicides on Way OutInsects in the City: Arsenical Herbicides on Way Out
This week the U.S. EPA announced that all registrations of the organic arsenical herbicides, including the popular Dallisgrass ... The decision comes as a result of a 2006 Reregistration Eligibility Decision (RED) that concluded that the arsenical herbicides ... arsenicals_fs.html. Dallisgrass is the real problem weed for southern turfgrass, for which there are still no good alternatives ...
https://insectsinthecity.blogspot.com/2009/02/arsenical-herbicides-on-way-out.html
CDC - Immediately Dangerous to Life or Health Concentrations (IDLH): Hydrogen cyanide - NIOSH Publications and ProductsCDC - Immediately Dangerous to Life or Health Concentrations (IDLH): Hydrogen cyanide - NIOSH Publications and Products
5. Gates M, Williams J, Zapp JA [1946]. Arsenicals. In: Summary technical report of Division 9, NRDC. Vol. 1. Chemical warfare ...
https://www.cdc.gov/niosh/idlh/74908.html
WBC count: MedlinePlus Medical EncyclopediaWBC count: MedlinePlus Medical Encyclopedia
A WBC count is a blood test to measure the number of white blood cells (WBCs) in the blood.
https://medlineplus.gov/ency/article/003643.htm
Arsenical Bronze - an Alloy - QS StudyArsenical Bronze - an Alloy - QS Study
Arsenical bronze is a bronze alloy in which arsenic is added to copper instead of or in addition to tin or other component ... Health effects of arsenical bronze use. Arsenic has a vaporization point of 615 °C, therefore arsenical oxide will be lost from ... Modern uses of arsenical bronze. In the present era, arsenical bronze has found minimal use. The closest counterpart appears to ... Arsenical bronze is a bronze alloy in which arsenic is added to copper instead of or in addition to tin or other component ...
https://qsstudy.com/arsenical-bronze-an-alloy/
CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Treatment & Management: Prehospital Care, Emergency Department Care,...CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Treatment & Management: Prehospital Care, Emergency Department Care,...
The 4 organic arsenicals are lewisite (L), methyldichloroarsine (MD), phenyldichloroarsine (PD), and ethyldichloroarsine (ED). ... CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL Treatment & Management. Updated: Mar 30, 2022 ... encoded search term (CBRNE - Vesicants%2C Organic Arsenicals - L%2C ED%2C MD%2C PD%2C HL) and CBRNE - Vesicants, Organic ... The arsenicals. Military Chemical and Biological Agents: Chemical and Toxicological Properties. 1987. 17-43. ...
https://emedicine.staging.medscape.com/article/832158-treatment
Browsing by SubjectBrowsing by Subject
JavaScript is disabled for your browser. Some features of this site may not work without it ...
https://apps.who.int/iris/browse?rpp=20&offset=401&etal=-1&sort_by=-1&type=mesh&starts_with_previous=B&order=ASC
Arsenic Toxicity: Where is Arsenic Found? | Environmental Medicine | ATSDRArsenic Toxicity: Where is Arsenic Found? | Environmental Medicine | ATSDR
Component Uses of Arsenicals. Discontinued arsenic-containing pesticides may still be found in some U.S. farms and homes [ATSDR ... Use of arsenicals in chemical warfare.. *Chlorovinyl dichloroarsine (also known as lewisite) was developed as a chemical ... Wood treated with CCA is known as "pressure treated wood". In response to consumer concerns, U.S. manufacturers of arsenical ... Arsine gas, the most toxic arsenical (acute exposures), is used commercially in the microelectronics industry, and it is ...
https://www.atsdr.cdc.gov/csem/arsenic/where_arsenic.html
Comparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells | UBC ChemistryComparative toxicity of trivalent and pentavalent inorganic and methylated arsenicals in rat and human cells | UBC Chemistry
Trivalent dimethylated arsenicals were at least as cytotoxic as trivalent iAs (arsenite) for most cell types. Pentavalent ... Among the arsenicals examined, trivalent monomethylated species were the most cytotoxic in all cell types. ... Pentavalent mono- and dimethylated arsenicals are less acutely toxic than iAs. However, little is known about the toxicity of ... In the work reported here the toxicities of iAs and trivalent and pentavalent methylated arsenicals were examined in cultured ...
https://chem.ubc.ca/comparative-toxicity-trivalent-and-pentavalent-inorganic-and-methylated-arsenicals-rat-and-human
Injuries Among Survivors of the Terrorist AttackInjuries Among Survivors of the Terrorist Attack
Diseases & Conditions CBRNE - Vesicants, Organic Arsenicals - L, ED, MD, PD, HL b:recommendationscuratedHasData : false ...
https://www.medscape.com/viewarticle/418274
CDC | Case Definition: Inorganic Arsenic PoisoningCDC | Case Definition: Inorganic Arsenic Poisoning
Peripheral neuropathy caused by arsenical intoxication. A study of 41 cases with observations on the effects of BAL (2,3 ...
https://emergency.cdc.gov/agent/arsenic/casedef.asp
Localized alveolar bone necrosis following the use of an arsenical paste: a case report | AVESİSLocalized alveolar bone necrosis following the use of an arsenical paste: a case report | AVESİS
Advanced Search Results - Public Health Image Library(PHIL)Advanced Search Results - Public Health Image Library(PHIL)
Categories: Arsenicals Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, CopyrightRestricted 9 images ...
https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Arsenicals&parentid=14075&catid=3492
Arsenic | Medical Management Guidelines | Toxic Substance Portal | ATSDR
Washing arsenical residues from the skin or eyes usually reduces the irritant effect. If arsenic trioxide is swallowed, ... Arsenicals can react violently with strong oxidizing materials and active metals (HSDB 2007; NIOSH 2005). Hydrogen gas can ... Hepatocellular injury after acute exposure to inorganic arsenicals is uncommon, but fatty infiltration of the liver, central ...
https://wwwn.cdc.gov/tsp/MMG/MMGDetails.aspx?mmgid=1424&toxid=3
WBC countWBC count
A WBC count is a blood test to measure the number of white blood cells (WBCs) in the blood. WBCs are also called leukocytes. They help fight infections.
https://www.ucsfhealth.org/medical-tests/wbc-count
Award Information | HHS TAGGSAward Information | HHS TAGGS
UAB Research Center of Excellence in Arsenicals. * Award Number: U54ES030246 * ORGANIZATION: NATIONAL INSTITUTE OF ...
https://taggs.hhs.gov/Detail/AwardDetail?arg_AwardNum=U54ES030246&arg_ProgOfficeCode=123
Plant and Chemical Poisonings | Iowa State UniversityPlant and Chemical Poisonings | Iowa State University
Phenylarsonic (Organic Arsenical) Poisoning. Roxarsone and arsanilic acid are used to promote growth and to treat swine ... Prevention of organic arsenical poisoning can be achieved simply by correct management of these legal compounds during feed ... Blindness is not typical of poisoning with other organic arsenicals. Paralyzed pigs remain alert. If provided with feed and ...
https://vetmed.iastate.edu/vdpam/FSVD/swine/index-diseases/plant-chemical-poisonings
Signs and Symptoms of Pesticide PoisoningSigns and Symptoms of Pesticide Poisoning
Arsenical Herbicides. Examples include Ansar and Montar. Acute arsenic poisoning usually appears within one hour of ingestion. ... Arsenical wood preservatives (chromated copper arsenate [CCA] and ammoniacal copper arsenate [ACA]) can cause nausea, headache ... Prolonged exposure to arsenical wood preservatives can result in persistent headache, abdominal distress, salivation, low grade ...
https://www.headlice.org/comb/what-are-head-lice-and-nits/chemical-concerns/signs-and-symptoms-of-pesticide-poisoning/
Search Results: Ankle - skin of, Rash or multiple lesions
Start your 30 day free trial. Cancel at any time. Trusted and used in more than 1,700 hospitals, large clinics, and medical schools across the globe.. Start Trial Subscriber Sign In ...
https://logicalimages.com/visualdx/differential/ankle+-+skin+of/rash+or+multiple+lesions?moduleId=100&findingId=1249,25221&reqFId=1249
Nutritional deficiency and arsenical manifestations: A perspective study in an arsenic-endemic region of West Bengal, India -...
Increased risk of arsenical skin lesions was found for those in the lowest quintile of protein intake (v. highest quintile: OR ... Nutritional deficiency and arsenical manifestations: A perspective study in an arsenic-endemic region of West Bengal, India. D ... View more info for Nutritional deficiency and arsenical manifestations: a perspective study in an arsenic-endemic region of ... are found to be associated with arsenical skin lesions in West Bengal. Copyright © The Authors 2012. ...
https://research.caluniv.ac.in/publication/nutritional-deficiency-and-arsenical-manifestations-a-perspective
NIOSHTIC-2 Search Results - Full View
... arsenicals, trauma; infections and infestations including bacteria, mycobacteria, viruses, fungi, parasites; disorders of hair ...
http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=radiation&f1=%2A&Startyear=&Adv=0&terms=1&EndYear=&Limit=10000&sort=&D1=10&PageNo=104&RecNo=1033&View=f&
Heartworm Disease in Dogs, Cats, and Ferrets - Circulatory System - MSD Veterinary ManualHeartworm Disease in Dogs, Cats, and Ferrets - Circulatory System - MSD Veterinary Manual
Non-arsenical (Macrolide + Doxycycline) Adulticidal Therapy Cases in which non-arsenical adulticidal therapy might be ... Arsenical (Melarsomine) Adulticidal Therapy The only approved heartworm adulticide is melarsomine dihydrochloride, which is ... Non-arsenical protocols using ivermectin can be used in cases of melarsomine failure or significant financial constraints ... non-arsenical adulticide: preventive dosage ivermectin or moxidectin (twice a month for 6 months) + doxycycline, exercise ...
https://www.msdvetmanual.com/en-au/veterinary/circulatory-system/heartworm-disease/heartworm-disease-in-dogs,-cats,-and-ferrets
Daus, Dr. Birgit - Helmholtz-Centre for Environmental Research
Biodegradation of phenyl arsenicals in groundwater - natural attenuation of chemical warfare agents. In: Jean, J.-S., Bundschuh ... Analytical investigations of phenyl arsenicals in groundwater. Talanta 75 (2), 376 - 379. full text (doi) ...
https://www.ufz.de/index.php?en=38666
Raised with arsenical drugsTrivalent methylated arsenicalsArsenicOrganicInorganicToxicityRoxarsoneWest BengalCopperBronzePeripheralPasteAcidSpeciesToxicPoultryStudyProtect cellsDrugsFoundArticlePromote growthSkinAgentsEffectTypes
Raised with arsenical drugs1
  • The newly published CLF study is the first to quantify concentrations of specific forms of arsenic (most notably inorganic arsenic) within chicken meat, and the first to directly compare arsenic concentrations in meat samples from birds likely raised with arsenical drugs to samples from chickens raised without these drugs. (civileats.com)
Trivalent methylated arsenicals1
  • These results suggest that (1) trivalent methylated arsenicals, intermediary products of arsenic methylation, may significantly contribute to the adverse effects associated with exposure to iAs, and (2) high methylation capacity does not protect cells from the acute toxicity of trivalent arsenicals. (ubc.ca)
Arsenic8
  • A cacl2-o2 leaching procedure and metal-recovery method for treating an arsenical cu-co sulfide concentrate was developed by the Bureau of Mines as an alternative to smelting, which is no longer considered an environmentally acceptable method for treating arsenic- containing ores. (cdc.gov)
  • Arsenical bronze is a bronze alloy in which arsenic is added to copper instead of or in addition to tin or other component metals. (qsstudy.com)
  • Because copper ore is frequently naturally contaminated with arsenic, the term "arsenical bronze" is normally applied exclusively to alloys having an arsenic level greater than 1% by weight, in order to separate it from possible accidental arsenic additions. (qsstudy.com)
  • Arsenical bronze daggers from the Caucasus and other artifacts from various locales have an arsenic-rich surface layer that may have been intentionally manufactured by ancient craftsmen, and Mexican bells were made of copper with enough arsenic to color them silver. (qsstudy.com)
  • Arsenic has a vaporization point of 615 °C, therefore arsenical oxide will be lost from the melt before or during casting, and fumes from mining and ore processing fires have long been recognized to harm the nervous system, eyes, lungs, and skin. (qsstudy.com)
  • Turns out that when you feed arsenical drugs to livestock, the arsenic doesn't just magically disappear. (civileats.com)
  • 70 percent of samples from conventional producers without policies prohibiting arsenical use had inorganic arsenic levels that exceeded the aforementioned FDA safety standard. (civileats.com)
  • Researchers found that the resulting transgenic plant acquired the potential for methylating inorganic arsenic to a variety of harmless organic species, including volatile arsenicals. (org.in)
Organic8
  • Physical signs of organic arsenical exposure are similar to those of mustard agents. (medscape.com)
  • Organic arsenicals cause immediate signs, whereas signs of mustard exposure appear after a latent period of several hours. (medscape.com)
  • This week the U.S. EPA announced that all registrations of the organic arsenical herbicides, including the popular Dallisgrass killer, MSMA would begin being phased out. (blogspot.com)
  • however, organic arsenicals attack rubber and can cause it to break down with prolonged exposure. (medscape.com)
  • Victims of severe toxicity from an organic arsenical may require prolonged care for dermatologic, ophthalmic, and pulmonary sequelae. (medscape.com)
  • Blindness is not typical of poisoning with other organic arsenicals. (iastate.edu)
  • Prevention of organic arsenical poisoning can be achieved simply by correct management of these legal compounds during feed preparation or medication. (iastate.edu)
  • The researchers tested samples of three types of chicken breast: organic (which means the meat came from birds that were required to be raised without arsenical drugs), antibiotic-free (which means the birds were raised without antibiotics, but not necessarily without arsenicals) and conventional (which, given the high rate of arsenical use when the study was conducted between December 2010 and June 2011, means the birds likely received arsenical drugs). (civileats.com)
Inorganic1
  • Biomethylation is considered a major detoxification pathway for inorganic arsenicals (iAs). (ubc.ca)
Toxicity1
  • To characterize the role of methylation in the protection against toxicity of arsenicals, the capacities of cells to produce methylated metabolites were also examined. (ubc.ca)
Roxarsone1
  • Moreover, Pfizer still sells nitarsone, another arsenical drug similar to roxarsone. (civileats.com)
West Bengal2
  • IMSEAR at SEARO: Arsenical dermatosis from tubewell water in West Bengal. (who.int)
  • Conclusions Deficiencies of Zn, Mg and Cu, in addition to protein, B vitamins and choline, are found to be associated with arsenical skin lesions in West Bengal. (caluniv.ac.in)
Copper2
  • Calcium Chloride-oxygen Leaching and Metals Recovery from an Arsenical Copper-cobalt Concentrate. (cdc.gov)
  • The closest counterpart appears to be arsenical copper, defined as copper with less than 0.5 wt percent As, which is below the accepted level in archaeological artifacts. (qsstudy.com)
Bronze1
  • In the present era, arsenical bronze has found minimal use. (qsstudy.com)
Peripheral1
  • Peripheral neuropathy caused by arsenical intoxication. (cdc.gov)
Paste1
  • bakeries, where children slowly roast before the ovens," "binderies, paper-box and paint factories, where arsenical paper, rotting paste, and the poison of the paints are injurious. (slate.com)
Acid1
  • Topical delivery of nordihydroguaretic acid for attenuating cutaneous damage caused by arsenicals. (medscape.com)
Species1
  • Among the arsenicals examined, trivalent monomethylated species were the most cytotoxic in all cell types. (ubc.ca)
Toxic2
  • Pentavalent mono- and dimethylated arsenicals are less acutely toxic than iAs. (ubc.ca)
  • Arsenicals are known for producing toxic effects in humans, if not processed as per classical text therefore, the present study was aim to generate data for the safety of RM in albino rats. (journaltocs.ac.uk)
Poultry1
  • The researchers also contacted the various poultry producers to determine whether they had established policies to prohibit arsenical use, and divided the samples accordingly. (civileats.com)
Study1
  • Today, researchers at the Johns Hopkins Center for a Livable Future published a study in the scientific journal Environmental Health Perspectives that provided further evidence of the risks associated with the use of arsenicals in animal agriculture. (civileats.com)
Protect cells1
  • Do Superoxide Dismutase and Catalase Protect Cells from DNA Damage Induced by Active Arsenicals? (researchgate.net)
Drugs1
  • The drug caused healing of local lesions in all five cases that was comparable to the favorable effect usually obtained with arsenical drugs. (ajtmh.org)
Found1
Article1
  • Cet article se propose de décrire de façon succincte la chaîne de production kuro-araxe dans son entièreté, en commençant par l'extraction et la préparation du minerai, sa mise en poudre et enfin l'opération de réduction. (openedition.org)
Promote growth1
  • Back in the 1940s, producers started using arsenicals to promote growth, treat disease and improve meat pigmentation. (civileats.com)
Skin1
  • In the work reported here the toxicities of iAs and trivalent and pentavalent methylated arsenicals were examined in cultured human cells derived from tissues that are considered a major site for iAs methylation (liver) or targets for carcinogenic effects associated with exposure to iAs (skin, urinary bladder, and lung). (ubc.ca)
Agents1
  • Li C, Srivastava RK, Athar M. Biological and environmental hazards associated with exposure to chemical warfare agents: arsenicals. (medscape.com)
Effect1
  • Arsenicals had limited effect on the pest, so there was little to prevent its rapid spread through the orange and lemon groves of California in the 1880's. (wikisummaries.org)
Types1
  • Trivalent dimethylated arsenicals were at least as cytotoxic as trivalent iAs (arsenite) for most cell types. (ubc.ca)
RTECS:CG0525000 - Arsenic - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH
RTECS:CG0525000 - Arsenic - The Registry of Toxic Effects of Chemical Substances | CDC/NIOSH (cdc.gov)
WBC count: MedlinePlus Medical Encyclopedia
WBC count: MedlinePlus Medical Encyclopedia (medlineplus.gov)
Browsing by Subject Arsenicals
Browsing by Subject "Arsenicals" (extranet.who.int)
Case Definitions for Chemical Poisoning
Case Definitions for Chemical Poisoning (cdc.gov)
Arsenic: MedlinePlus
Arsenic: MedlinePlus (medlineplus.gov)
Arsenic Toxicity: Where is Arsenic Found? | Environmental Medicine | ATSDR
Arsenic Toxicity: Where is Arsenic Found? | Environmental Medicine | ATSDR (atsdr.cdc.gov)
Arsenic Toxicity: What are the Routes of Exposure for Arsenic? | Environmental Medicine | ATSDR
Arsenic Toxicity: What are the Routes of Exposure for Arsenic? | Environmental Medicine | ATSDR (atsdr.cdc.gov)
RCSB PDB - 3F6V: Crystal structure of Possible transcriptional regulator for arsenical resistance
RCSB PDB - 3F6V: Crystal structure of Possible transcriptional regulator for arsenical resistance (rcsb.org)
Arsine : human health aspects
Arsine : human health aspects (extranet.who.int)
Arsenic Toxicity: What are the Physiologic Effects of Arsenic Exposure? | Environmental Medicine | ATSDR
Arsenic Toxicity: What are the Physiologic Effects of Arsenic Exposure? | Environmental Medicine | ATSDR (atsdr.cdc.gov)
Heartworm Disease in Dogs, Cats, and Ferrets - Circulatory System - MSD Veterinary Manual
Heartworm Disease in Dogs, Cats, and Ferrets - Circulatory System - MSD Veterinary Manual (msdvetmanual.com)
Signs and Symptoms of Pesticide Poisoning
Signs and Symptoms of Pesticide Poisoning (headlice.org)
Search Results: Ankle - skin of, Rash or multiple lesions
Search Results: Ankle - skin of, Rash or multiple lesions (logicalimages.com)
Arsenic Toxicity: What Is Arsenic? | Environmental Medicine | ATSDR
Arsenic Toxicity: What Is Arsenic? | Environmental Medicine | ATSDR (atsdr.cdc.gov)
Daus, Dr. Birgit - Helmholtz-Centre for Environmental Research
Daus, Dr. Birgit - Helmholtz-Centre for Environmental Research (ufz.de)
Andrew KLIGERMAN | Research biologist | Ph.D. | United States Environmental Protection Agency | US EPA | Integrated Systems...
Andrew KLIGERMAN | Research biologist | Ph.D. | United States Environmental Protection Agency | US EPA | Integrated Systems... (researchgate.net)
Reanalyzing the 1900-1920 Sleeping Sickness Epidemic in Uganda - Volume 10, Number 4-April 2004 - Emerging Infectious Diseases...
Reanalyzing the 1900-1920 Sleeping Sickness Epidemic in Uganda - Volume 10, Number 4-April 2004 - Emerging Infectious Diseases... (wwwnc.cdc.gov)
Figure 3 - Reanalyzing the 1900-1920 Sleeping Sickness Epidemic in Uganda - Volume 10, Number 4-April 2004 - Emerging...
Figure 3 - Reanalyzing the 1900-1920 Sleeping Sickness Epidemic in Uganda - Volume 10, Number 4-April 2004 - Emerging... (wwwnc.cdc.gov)
Arsenic Toxicity: Clinical Assessment | Environmental Medicine | ATSDR
Arsenic Toxicity: Clinical Assessment | Environmental Medicine | ATSDR (atsdr.cdc.gov)
CuFAQs3
CuFAQs3 (wetwebmedia.com)
IndexCat
IndexCat (indexcat.nlm.nih.gov)
SCOPe 2.07: Domain d2fzvb3: 2fzv B:0-0
SCOPe 2.07: Domain d2fzvb3: 2fzv B:0-0 (scop.berkeley.edu)
East African Trypanosomiasis in a Pregnant Traveler - Volume 15, Number 11-November 2009 - Emerging Infectious Diseases journal...
East African Trypanosomiasis in a Pregnant Traveler - Volume 15, Number 11-November 2009 - Emerging Infectious Diseases journal... (wwwnc.cdc.gov)
Details - Public Health Image Library(PHIL)
Details - Public Health Image Library(PHIL) (phil.cdc.gov)
Details - Public Health Image Library(PHIL)
Details - Public Health Image Library(PHIL) (phil.cdc.gov)
Details - Public Health Image Library(PHIL)
Details - Public Health Image Library(PHIL) (phil.cdc.gov)
Details - Public Health Image Library(PHIL)
Details - Public Health Image Library(PHIL) (phil.cdc.gov)