Arsenic
Arsenic Poisoning
Oxides
Water Pollutants, Chemical
Water Supply
Nails
Environmental Exposure
Water Pollution, Chemical
Soil Pollutants
Environmental Monitoring
Water Pollutants
Spectrophotometry, Atomic
Pteris
Arsenate Reductases
Food Contamination
Antimony
Ion Pumps
Arsenite Transporting ATPases
Environmental Pollutants
Metallurgy
Metals, Heavy
Aquaglyceroporins
Hair
Arsenic targets tubulins to induce apoptosis in myeloid leukemia cells. (1/1444)
Arsenic exhibits a differential toxicity to cancer cells. At a high concentration (>5 microM), As2O3 causes acute necrosis in various cell lines. At a lower concentration (0.5-5 microm), it induces myeloid cell maturation and an arrest in metaphase, leading to apoptosis. As2O3-treated cells have features found with both tubulin-assembling enhancers (Taxol) and inhibitors (colchicine). Prior treatment of monomeric tubulin with As2O3 markedly inhibits GTP-induced polymerization and microtubule formation in vitro but does not destabilize GTP-induced tubulin polymers. Cross-inhibition experiments indicate that As2O3 is a noncompetitive inhibitor of GTP binding to tubulin. These observations correlate with the three-dimensional structure of beta-tubulin and suggest that the cross-linking of two vicinal cysteine residues (Cys-12 and Cys-213) by trivalent arsenic inactivates the GTP binding site. Furthermore, exogenous GTP can prevent As2O3-induced mitotic arrest. (+info)High concentrations of heavy metals in neighborhoods near ore smelters in northern Mexico. (2/1444)
In developing countries, rapid industrialization without environmental controls has resulted in heavy metal contamination of communities. We hypothesized that residential neighborhoods located near ore industries in three northern Mexican cities would be heavily polluted with multiple contaminants (arsenic, cadmium, and lead) and that these sites would be point sources for the heavy metals. To evaluate these hypotheses, we obtained samples of roadside surface dust from residential neighborhoods within 2 m of metal smelters [Torreon (n = 19)] and Chihuahua (n = 19)] and a metal refinery [Monterrey (n = 23)]. Heavy metal concentrations in dust were mapped with respect to distance from the industrial sites. Correlation between dust metal concentration and distance was estimated with least-squares regression using log-transformed data. Median dust arsenic, cadmium, and lead concentrations were 32, 10, and 277 microg/g, respectively, in Chihuahua; 42, 2, and 467 microg/g, respectively, in Monterrey, and 113, 112, and 2,448 microg/g, respectively, in Torreon. Dust concentrations of all heavy metals were significantly higher around the active smelter in Torreon, where more than 90% of samples exceeded Superfund cleanup goals. At all sites, dust concentrations were inversely related to distance from the industrial source, implicating these industries as the likely source of the contamination. We concluded that residential neighborhoods around metal smelting and refining sites in these three cities are contaminated by heavy metals at concentrations likely to pose a health threat to people living nearby. Evaluations of human exposure near these sites should be conducted. Because multiple heavy metal pollutants may exist near smelter sites, researchers should avoid attributing toxicity to one heavy metal unless others have been measured and shown not to coexist. (+info)Retinoic acid and arsenic synergize to eradicate leukemic cells in a mouse model of acute promyelocytic leukemia. (3/1444)
In acute promyelocytic leukemia (APL) patients, retinoic acid (RA) triggers differentiation while arsenic trioxide (arsenic) induces both a partial differentiation and apoptosis. Although their mechanisms of action are believed to be distinct, these two drugs both induce the catabolism of the oncogenic promyelocytic leukemia (PML)/RARalpha fusion protein. While APL cell lines resistant to one agent are sensitive to the other, the benefit of combining RA and arsenic in cell culture is controversial, and thus far, no data are available in patients. Using syngenic grafts of leukemic blasts from PML/RARalpha transgenic mice as a model for APL, we demonstrate that arsenic induces apoptosis and modest differentiation, and prolongs mouse survival. Furthermore, combining arsenic with RA accelerates tumor regression through enhanced differentiation and apoptosis. Although RA or arsenic alone only prolongs survival two- to threefold, associating the two drugs leads to tumor clearance after a 9-mo relapse-free period. These studies establishing RA/arsenic synergy in vivo prompt the use of combined arsenic/RA treatments in APL patients and exemplify how mouse models of human leukemia can be used to design or optimize therapies. (+info)Interference in the quantitation of methylated arsenic species in human urine. (4/1444)
The aim of this paper is to report on the presence of chemical interferences in the quantitation of methylated arsenic species in human urine when using a method based on selective volatile arsine species generation, chromatographic separation, and hydride generation atomic absorption spectrometry (HGAAS) detection. An abnormal profile of methylated arsenic species characterized by the absence of the peak corresponding to dimethylarsinic acid (DMA) was observed in urine from some individuals exposed to arsenic via drinking water and living in rural communities of northwestern Argentina. The absence of this peak persisted even after the addition of known amounts of DMA to the samples. However, the DMA peak appeared after urine digestion with hydrochloric acid (2M). Samples showing interferences were provided by individuals who had mate consumption and coca-leaf chewing habits. Because the relative proportions of methylated arsenic species present in urine have been used to evaluate the efficiency of the methylation process, interferences in the formation or detection of methylarsines may cause underestimation of As exposure and also lead to erroneous conclusions about relative biomethylation efficiencies. Therefore, we recommend that urine samples should be digested with 2M HCl before performing speciation analysis using HGAA techniques. Further studies on the impact of this type of interferences on other arsenic speciation methods are also required. (+info)Drinking water arsenic in Utah: A cohort mortality study. (5/1444)
The association of drinking water arsenic and mortality outcome was investigated in a cohort of residents from Millard County, Utah. Median drinking water arsenic concentrations for selected study towns ranged from 14 to 166 ppb and were from public and private samples collected and analyzed under the auspices of the State of Utah Department of Environmental Quality, Division of Drinking Water. Cohort members were assembled using historical documents of the Church of Jesus Christ of Latter-day Saints. Standard mortality ratios (SMRs) were calculated. Using residence history and median drinking water arsenic concentration, a matrix for cumulative arsenic exposure was created. Without regard to specific exposure levels, statistically significant findings include increased mortality from hypertensive heart disease [SMR = 2.20; 95% confidence interval (CI), 1.36-3.36], nephritis and nephrosis (SMR = 1.72; CI, 1.13-2.50), and prostate cancer (SMR = 1.45; CI, 1.07-1. 91) among cohort males. Among cohort females, statistically significant increased mortality was found for hypertensive heart disease (SMR = 1.73; CI, 1.11-2.58) and for the category of all other heart disease, which includes pulmonary heart disease, pericarditis, and other diseases of the pericardium (SMR = 1.43; CI, 1.11-1.80). SMR analysis by low, medium, and high arsenic exposure groups hinted at a dose relationship for prostate cancer. Although the SMRs by exposure category were elevated for hypertensive heart disease for both males and females, the increases were not sequential from low to high groups. Because the relationship between health effects and exposure to drinking water arsenic is not well established in U.S. populations, further evaluation of effects in low-exposure populations is warranted. (+info)Mutational spectrum of p53 gene in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan. (6/1444)
To understand the role of p53 tumour suppressor gene in the carcinogenesis of arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan, we collected tumour samples from 23 patients with Bowen's disease, seven patients with basal cell carcinomas (BCC) and nine patients with squamous cell carcinomas (SCC). The result showed that p53 gene mutations were found in 39% of cases with Bowen's disease (9/23), 28.6% of cases with BCC (2/7) and 55.6% of cases with SCC (5/9). Most of the mutation sites were located on exon 5 and exon 8. Moreover, the results from direct sequencing indicated that missense mutations were found at codon 149 (C-->T) in one case, codon 175 (G-->A) in three cases, codon 273 (G-->C) in three cases, codon 292 (T-->A) in one case, codon 283 (G-->T) in one case, codon 172 (T-->C) in one case and codon 284 (C-->A) in one case. In addition, silent mutations were also found in four cases. These mutations were located at codons 174, 253, 289 and 298 respectively. In immunohistochemistry analysis, p53 overexpression was found in 43.5% (10/23) of cases with Bowen's disease, 14% (1/7) of cases with BCC and 44% (4/9) of cases with SSC. These findings showed that p53 gene mutation rate in arsenic-related skin cancers from the blackfoot disease endemic area of Taiwan is high and that the mutation types are different from those in UV-induced skin cancers. (+info)The enigma of arsenic carcinogenesis: role of metabolism. (7/1444)
Inorganic arsenic is considered a high-priority hazard, particularly because of its potential to be a human carcinogen. In exposed human populations, arsenic is associated with tumors of the lung, skin, bladder, and liver. While it is known to be a human carcinogen, carcinogenesis in laboratory animals by this metalloid has never been convincingly demonstrated. Therefore, no animal models exist for studying molecular mechanisms of arsenic carcinogenesis. The apparent human sensitivity, combined with our incomplete understanding about mechanisms of carcinogenic action, create important public health concerns and challenges in risk assessment, which could be met by understanding the role of metabolism in arsenic toxicity and carcinogenesis. This symposium summary covers three critical major areas involving arsenic metabolism: its biodiversity, the role of arsenic metabolism in molecular mechanisms of carcinogenesis, and the impact of arsenic metabolism on human risk assessment. In mammals, arsenic is metabolized to mono- and dimethylated species by methyltransferase enzymes in reactions that require S-adenosyl-methionine (SAM) as the methyl donating cofactor. A remarkable species diversity in arsenic methyltransferase activity may account for the wide variability in sensitivity of humans and animals to arsenic toxicity. Arsenic interferes with DNA methyltransferases, resulting in inactivation of tumor suppressor genes through DNA hypermethylation. Other studies suggest that arsenic-induced malignant transformation is linked to DNA hypomethylation subsequent to depletion of SAM, which results in aberrant gene activation, including oncogenes. Urinary profiles of arsenic metabolites may be a valuable tool for assessing human susceptibility to arsenic carcinogenesis. While controversial, the idea that unique arsenic metabolic properties may explain the apparent non-linear threshold response for arsenic carcinogenesis in humans. In order to address these outstanding issues, further efforts are required to identify an appropriate animal model to elucidate carcinogenic mechanisms of action, and to define dose-response relationships. (+info)Arsenic: health effects, mechanisms of actions, and research issues. (8/1444)
A meeting on the health effects of arsenic (As), its modes of action, and areas in need of future research was held in Hunt Valley, Maryland, on 22-24 September 1997. Exposure to As in drinking water has been associated with the development of skin and internal cancers and noncarcinogenic effects such as diabetes, peripheral neuropathy, and cardiovascular diseases. There is little data on specific mechanism(s) of action for As, but a great deal of information on possible modes of action. Although arsenite [As(III)] can inhibit more than 200 enzymes, events underlying the induction of the noncarcinogenic effects of As are not understood. With respect to carcinogenicity, As can affect DNA repair, methylation of DNA, and increase radical formation and activation of the protooncogene c-myc, but none of these potential pathways have widespread acceptance as the principal etiologic event. In addition, there are no accepted models for the study of As-induced carcinogenesis. At the final meeting session we considered research needs. Among the most important areas cited were a) As metabolism and its interaction with cellular constituents; b) possible bioaccumulation of As; c) interactions with other metals; d) effects of As on genetic material; e) development of animal models and cell systems to study effects of As; and f) a better characterization of human exposures as related to health risks. Some of the barriers to the advancement of As research included an apparent lack of interest in the United States on As research; lack of relevant animal models; difficulty with adoption of uniform methodologies; lack of accepted biomarkers; and the need for a central storage repository for stored specimens. (+info)The symptoms of arsenic poisoning can vary depending on the amount and duration of exposure, as well as the individual's age and overall health. Some common symptoms include:
* Nausea, vomiting and diarrhea
* Abdominal pain and cramping
* Headaches and dizziness
* Skin changes such as numbness or discoloration
* Respiratory problems such as coughing and shortness of breath
If left untreated, arsenic poisoning can lead to more severe health effects, including:
* Damage to the liver, kidneys and bladder
* Increased risk of cancer
* Death
The treatment for arsenic poisoning typically involves removing the source of exposure, providing supportive care to manage symptoms and using medications to remove arsenic from the body. Chelation therapy may also be used to remove heavy metals from the body. In severe cases, hospitalization may be required to monitor and treat complications.
Prevention is key in avoiding arsenic poisoning. This can include reducing exposure to arsenic-containing products, testing well water for arsenic and taking steps to reduce exposure in areas where arsenic is present in the environment. If you suspect you or someone else has been exposed to arsenic, it is important to seek medical attention immediately.
In summary, Arsenic Poisoning can be a serious health hazard, but with prompt and appropriate treatment, it can be effectively managed. Prevention through reducing exposure and testing for arsenic is also crucial in avoiding this condition.
Some common types of skin diseases include:
1. Acne: a condition characterized by oil clogged pores, pimples, and other blemishes on the skin.
2. Eczema: a chronic inflammatory skin condition that causes dry, itchy, and scaly patches on the skin.
3. Psoriasis: a chronic autoimmune skin condition characterized by red, scaly patches on the skin.
4. Dermatitis: a term used to describe inflammation of the skin, often caused by allergies or irritants.
5. Skin cancer: a type of cancer that affects the skin cells, often caused by exposure to UV radiation from the sun or tanning beds.
6. Melanoma: the most serious type of skin cancer, characterized by a mole that changes in size, shape, or color.
7. Vitiligo: a condition in which white patches develop on the skin due to the loss of pigment-producing cells.
8. Alopecia: a condition characterized by hair loss, often caused by autoimmune disorders or genetics.
9. Nail diseases: conditions that affect the nails, such as fungal infections, brittleness, and thickening.
10. Mucous membrane diseases: conditions that affect the mucous membranes, such as ulcers, inflammation, and cancer.
Skin diseases can be diagnosed through a combination of physical examination, medical history, and diagnostic tests such as biopsies or blood tests. Treatment options vary depending on the specific condition and may include topical creams or ointments, oral medications, light therapy, or surgery.
Preventive measures to reduce the risk of skin diseases include protecting the skin from UV radiation, using sunscreen, wearing protective clothing, and avoiding exposure to known allergens or irritants. Early detection and treatment can help prevent complications and improve outcomes for many skin conditions.
Arsenic
Arsenic trifluoride
Arsenic pentasulfide
Arsenic compounds
Arsenic fluoride
Arsenic triselenide
Arsenic minerals
Arsenic sulfide
Arsenic biochemistry
Arsenic pentoxide
Arsenic trioxide
Arsenic Lullaby
Arsenic oxide
Arsenic cycle
Mr. Arsenic
Arsenic Lake
Arsenic trisulfide
Arsenic tribromide
Arsenic pentachloride
Arsenic triiodide
Arsenic dioxide
Arsenic trichloride
Arsenic chloride
Arsenic pentafluoride
Arsenic acid
Arsenic (disambiguation)
Arsenic poisoning
Arsenic Act 1851
Toroku arsenic disease
Arsenic(III) telluride
Arsenic | NIOSH | CDC
Arsenic | ToxFAQs™ | ATSDR
arsenic molecular entity (CHEBI:22632)
Arsenic | Toxzine | ATSDR
CDC Arsenic | Emergency Preparedness & Response
Arsenic: MedlinePlus
Keurig Dr Pepper recalls bottled water with high arsenic levels - MarketWatch
Arsenic, Iron & Manganese Removal System | Environmental XPRT
arsenic | Blogs | CDC
Chicken Products are Contaminated with Arsenic
Colorado dentist accused of poisoning wife bought arsenic, police say
Browsing EB118 by Subject "Arsenic"
GNN - Ferns Remove Arsenic from Soil and Water
Exposure to arsenic and lead and neuropsychological development in Mexican children
Sample of the element Arsenic in the Periodic Table
arsenic-590x250 - Circle of Blue
CDC Arsenic | Emergency Preparedness & Response
Arsenic in tube well water in Bangladesh: health and economic impacts and implications for arsenic mitigation
FDA admits supermarket chickens test positive for arsenic | Grist
Arsenic Trioxide in a Hemodialytic Patient with Acute Promyelocytic Leukemia | Acta Haematologica | Karger Publishers
Arsenic in Drinking Water | California State Water Quality Control Board
Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh | Lamont-Doherty Earth...
Arsenic-Treated Lumber May Increase Cancer Risk - Center for Environmental Health
Paris Green pigment/poison, a sample of the element Arsenic in the Periodic Table
Arsenic | Washington State Department of Health
Arsenic and urine found in counterfeit beauty products | The Global Innovation Policy Center
Arsenic Exposure Testing In Houston | Any Lab Test Now
Arsenic in ground water in six districts of West Bengal, India: the biggest arsenic calamity in the world. Part 2. Arsenic...
A Compelling Use of Data in Public Health: Lead and Arsenic Poisoning in L.A. - Non Profit News | Nonprofit Quarterly
Compounds19
- Immediately Dangerous to Life or Health (IDHL) Value Profile: Arsenic (inorganic compounds, as As) -NIOSH reviews relevant scientific data and researches methods for developing IDLH values. (cdc.gov)
- NIOSH Skin Notation (SK) Profiles: Arsenic and Inorganic Arsenic Containing Compounds -DHHS (NIOSH) Publication No. 2017-184. (cdc.gov)
- Arsenic compounds are used to preserve wood, as pesticides, and in some industries. (medlineplus.gov)
- In the environment, arsenic is combined with oxygen, chlorine, and sulfur to form inorganic arsenic compounds. (cdc.gov)
- Arsenic in animals and plants combines with carbon and hydrogen to form organic arsenic compounds. (cdc.gov)
- Inorganic arsenic compounds are mainly used to preserve wood. (cdc.gov)
- Organic arsenic compounds are used as pesticides, primarily on cotton fields and orchards. (cdc.gov)
- Many common arsenic compounds can dissolve in water. (cdc.gov)
- Almost nothing is known regarding health effects of organic arsenic compounds in humans. (cdc.gov)
- Studies in animals show that some simple organic arsenic compounds are less toxic than inorganic forms. (cdc.gov)
- Most inorganic and organic arsenic compounds are white or colorless powders that do not evaporate. (cdc.gov)
- In the past, inorganic arsenic compounds were predominantly used as pesticides, primarily on cotton fields and in orchards. (cdc.gov)
- Inorganic arsenic compounds can no longer be used in agriculture. (cdc.gov)
- Some organic arsenic compounds are used as additives in animal feed. (cdc.gov)
- Another important use of arsenic compounds is in semiconductors and light-emitting diodes. (cdc.gov)
- In the process of converting and eliminating arsenic, the human body creates some organic arsenic types that are more toxic than their inorganic parent compounds. (upc-online.org)
- When arsenic combines with other chemical elements, it creates compounds, or chemical mixtures. (nih.gov)
- When people come in contact with arsenic in the environment, it is often with compounds. (nih.gov)
- Arsenic can be found in different forms - as pure arsenic, or combined with other elements to form compounds. (nih.gov)
Trioxide22
- Smelters may collect this dust and take out the arsenic as a compound called arsenic trioxide (As2O3). (cdc.gov)
- These highlights do not include all the information needed to use ARSENIC TRIOXIDE INJECTION safely and effectively. (nih.gov)
- See full prescribing information for ARSENIC TRIOXIDE INJECTION. (nih.gov)
- Patients with acute promyelocytic leukemia (APL) treated with arsenic trioxide injection have experienced symptoms of differentiation syndrome, which may be life-threatening or fatal. (nih.gov)
- Temporarily withhold arsenic trioxide injection. (nih.gov)
- Arsenic trioxide can cause QTc interval prolongation, complete atrioventricular block and torsade de pointes, which can be fatal. (nih.gov)
- Before administering arsenic trioxide, assess the QTc interval, correct electrolyte abnormalities, and consider discontinuing drugs known to prolong QTc interval. (nih.gov)
- Do not administer arsenic trioxide to patients with ventricular arrhythmia or prolonged QTc interval. (nih.gov)
- Withhold arsenic trioxide injection until resolution and resume at reduced dose for QTc prolongation. (nih.gov)
- Serious encephalopathy, including Wernicke's, has occurred with arsenic trioxide. (nih.gov)
- If Wernicke's encephalopathy is suspected, immediately interrupt arsenic trioxide and initiate parenteral thiamine. (nih.gov)
- Injection: 10 mg per 10 mL (1 mg per mL) and 12 mg per 6 mL (2 mg per mL) arsenic trioxide in single-dose vials. (nih.gov)
- Withhold arsenic trioxide for certain elevations in AST, alkaline phosphatase and bilirubin and resume at reduced dose upon resolution. (nih.gov)
- Arsenic trioxide is a human carcinogen. (nih.gov)
- Monitor patients with severe hepatic impairment (Child-Pugh Class C) for toxicity when treated with arsenic trioxide. (nih.gov)
- Arsenic was formerly used medically as Fowler's solution (1% arsenic trioxide) to treat inflammatory conditions such as asthma, psoriasis and leukemia, and as various organic arsenicals such as arsphenamine (Salvarsan), mapharsen and tryparsamide to treat syphilis and protozoal infections. (nih.gov)
- Arsenic is still a component of some traditional and herbal preparations and is still used to treat acute promyelocytic leukemia under the brand name Trisenox (arsenic trioxide) in intravenous doses of 10 mg daily for up to 60 days, followed by different dosing in consolidation and maintenance regimens. (nih.gov)
- Scientists in China discovered that the compound arsenic trioxide, pictured above, worked as a treatment for people with acute promyelocytic leukemia. (nih.gov)
- In the 1970s, scientists in China discovered that the compound arsenic trioxide worked for people with APL, including those whose leukemia returned after standard therapy. (nih.gov)
- Powell, of North Carolina's Wake Forest University, led some of the NIH-funded arsenic trioxide studies. (nih.gov)
- Before arsenic trioxide, there was another medical advance in the treatment of APL. (nih.gov)
- Researchers say, together, ATRA and arsenic trioxide have transformed the APL treatment landscape. (nih.gov)
Standard for Arsenic4
- NIOSH Criteria for a Recommended Standard: Occupational Exposure Standard for Arsenic -DHHS (NIOSH) Publication No. 75-149. (cdc.gov)
- But this hasn't stopped daytime TV aficionado Senator Charles Schumer from proposing legislation that would "set the first maximum standard for arsenic in apple juice. (gothamist.com)
- Tests reveal that the water at Kern Valley contains up to twice the federally permitted standard for arsenic levels, which is 10 parts per billion. (prisonlegalnews.org)
- Previous California and federal MCLs for arsenic were 50 μg/L. The online rulemaking file for this action can be found at the 2008 California Revised Drinking Water Standard for Arsenic rulemaking file . (ca.gov)
Exposure29
- Exposure to arsenic can also cause cancer. (cdc.gov)
- Workers may be harmed from exposure to arsenic. (cdc.gov)
- The following resources provide information about occupational exposure to arsenic. (cdc.gov)
- Exposure to arsenic can cause many health problems. (medlineplus.gov)
- Exposure to high levels of arsenic can cause death. (medlineplus.gov)
- Exposure to higher than average levels of arsenic occur mostly in the workplace, near hazardous waste sites, or in areas with high natural levels. (cdc.gov)
- There is some evidence that long-term exposure to arsenic in children may result in lower IQ scores. (cdc.gov)
- There is also some evidence that exposure to arsenic in the womb and early childhood may increase mortality in young adults. (cdc.gov)
- It is not known whether, or to what extent, CCA-treated wood products may contribute to exposure of people to arsenic. (cdc.gov)
- Long-term exposure to arsenic can cause more severe symptoms. (healthline.com)
- The best way to treat the condition is to eliminate arsenic exposure. (healthline.com)
- Vitamin E and selenium supplements have been used as alternative remedies to limit the effects of arsenic exposure. (healthline.com)
- The most serious problems tend to occur from exposure to arsenic over long periods of time. (healthline.com)
- The earlier you catch arsenic exposure, the better the outlook. (healthline.com)
- Nevertheless, arsenic is found widely in nature and accidental or intentional acute or chronic exposures to moderate or high levels of arsenic can cause liver injury, sometimes presenting long after the exposure. (nih.gov)
- The main goal of our ongoing R01 project (the Parent project) "Mechanisms of Arsenic-Induced Diabetes, (R01ES022697) is to characterize the role of MAsIII and DMAsIII in the diabetogenic effects of iAs exposure and to identify molecular mechanisms by which these arsenicals impair glucose homeostasis in laboratory mice. (nih.gov)
- Repeated exposure to arsenic over time can damage many organs, including the kidneys, stomach, and liver. (nih.gov)
- PROJECT SUMMARY/ABSTRACT Environmental arsenic exposure is associated with increased rates of pneumonia, bronchiectasis, and diabetes. (nih.gov)
- The underlying biochemical pathways that link arsenic exposure to lung disease and diabetes are difficult to study, but the symptoms of arsenic toxicity overlap with those of cystic fibrosis, a rare autosomal recessive disease most common in people of Northern European ancestry. (nih.gov)
- In this proposal, we plan to study whether CFTR dysfunction in adults with high arsenic exposure contributes to diminished lung function and diabetes. (nih.gov)
- As a consequence, occupational or accidental exposure to moderate or high doses of arsenic can occur, but are fortunately rare, at least in the United States and most of the developed world. (nih.gov)
- Liver injury can also occur with chronic arsenic exposure, typically with appearance of signs and symptoms of portal hypertension, without obvious cirrhosis (idiopathic or noncirrhotic portal hypertension). (nih.gov)
- Symptoms generally improve slowly upon withdrawal of arsenic exposure and long term survival is not uncommon, although porto-caval shunting may be needed to manage portal hypertension and variceal hemorrhage. (nih.gov)
- This cross-sectional study examined the effects of chronic exposure to lead (Pb), arsenic (AS) and undernutrition on the neuropsychological development of children. (nih.gov)
- Frequent exposure to even small amounts of lead, arsenic, cadmium, and other heavy metals is dangerous, in part because it's difficult for the human body to break them down or excrete them. (nbcdfw.com)
- Arsenic is both highly toxic and chronic exposure at low levels can lead to serious health consequences, including the development of cancers and skin conditions. (plymouth.ac.uk)
- Arsenic can also result in a number of non-cancer effects at higher levels of exposure (e.g., vascular effects or skin effects), but the cancer risk is the most sensitive endpoint, and the basis for the PHG. (ca.gov)
- The study aims to establish association between arsenic exposure and gallbladder carcinogenesis . (bvsalud.org)
- Moreover, n = 512 gallbladder cancer patients blood samples were also evaluated for the presence of arsenic to understand exposure level in the population . (bvsalud.org)
Contain arsenic2
- In 2003, U.S. manufacturers of wood preservatives containing arsenic began a voluntary transition from CCA to other wood preservatives that do not contain arsenic for certain residential uses, such as play structures, picnic tables, decks, fencing, and boardwalks. (cdc.gov)
- However, new research by the University of Plymouth has shown some parts of the site contain arsenic levels more than 400 times that permitted for park-type soil within government guidelines. (plymouth.ac.uk)
Toxicity2
- Inorganic - Research indicates that toxicity levels are higher and associated health effects are more severe with inorganic arsenic. (nih.gov)
- Accumulating evidence suggests that arsenic toxicity and cystic fibrosis share a common mechanism: dysfunction of the cystic fibrosis transmembrane regulator (CFTR). (nih.gov)
Naturally11
- Arsenic is a naturally occurring chemical element that is widely distributed in the Earth's crust. (nih.gov)
- Arsenic occurs naturally in soil and minerals and may enter the air, water, and land from wind-blown dust and may get into water from runoff and leaching. (cdc.gov)
- Inorganic arsenic occurs naturally in soil and in many kinds of rock. (cdc.gov)
- While arsenic is naturally occurring, it also comes in inorganic (or "man-made") formulas. (healthline.com)
- Arsenic occurs naturally in some foods, and only certain levels of inorganic arsenic is harmful. (gothamist.com)
- Arsenic is an element that exists naturally in the Earth's crust. (nih.gov)
- Arsenic spreads through the environment naturally through soil erosion (when soil is washed away by water) or storm water runoff (when water from rain or melted snow runs over the ground). (nih.gov)
- The Florida discovery marked the first time a plant had been found to naturally take up arsenic in high concentrations. (genomenewsnetwork.org)
- Parts of the West have high levels of arsenic in drinking water because of naturally occurring volcanic rocks underground. (genomenewsnetwork.org)
- After testing through the FDA, it was found that three lots of the food contain above the guidance level for naturally occurring inorganic arsenic. (komando.com)
- Although arsenic is notorious for being the poison of choice in countless true crime shows and mystery novels, this semi-metallic element is found naturally in soil, water, air, and some foods. (nih.gov)
Pesticides2
- Water, air, and soil contamination from mining and fracking, coal-fired power plants, arsenic-treated lumber, and arsenic-containing pesticides also contributes to increased levels of arsenic in certain locations. (nih.gov)
- Arsenic is used in pesticides and herbicides and is a byproduct of the mining of other metals, such as copper and lead. (nih.gov)
Sawdust or burni1
- Breathing sawdust or burning smoke from wood treated with arsenic. (cdc.gov)
Human carcinogen1
- The Department of Health and Human Services (DHHS) and the EPA have determined that inorganic arsenic is a known human carcinogen. (cdc.gov)
Carcinogen1
- Arsenic is a type of carcinogen that's gray, silver, or white in color. (healthline.com)
Treatment for acute promyelo1
- Chinese scientists were first to identify arsenic as a treatment for acute promyelocytic leukemia (APL). (nih.gov)
Doses of arsenic1
- Studies in animals show that large doses of arsenic that cause illness in pregnant females, can also cause low birth weight, fetal malformations, and even fetal death. (cdc.gov)
Forms of arsenic1
- While it used to be held that organic arsenics were not very toxic, scientific evidence now indicates that within the chicken, Roxarsone converts to the inorganic forms of arsenic believed to pose the greatest health risks to humans, according to IATP. (upc-online.org)
Poisonous to humans2
- Arsenic is extremely poisonous to humans. (healthline.com)
- Arsenic, which is poisonous to humans, is used to pressure treat lumber and to make semi-conductor chips. (genomenewsnetwork.org)
Concentrations of arsenic2
- Observed concentrations of arsenic (left) and cadmium (right) in 2017. (europa.eu)
- For the research, scientists used portable x-ray fluorescence (XRF) spectrometry to measure the concentrations of arsenic in soils and dusts in areas that are accessible to the public. (plymouth.ac.uk)
Amounts3
- Ingesting small amounts present in your food and water or breathing air containing arsenic. (cdc.gov)
- Small amounts of arsenic also may be released into the atmosphere from coal-fired power plants and incinerators because coal and waste products often contain some arsenic. (cdc.gov)
- The downside to any of these tests is that they can measure high amounts of arsenic in the body only. (healthline.com)
Levels26
- Arsenic levels in the environment can vary by locality, and it is found in water, air, and soil. (nih.gov)
- But, arsenic levels tend to be higher in groundwater sources, such as wells, than from surface sources, such as lakes or reservoirs. (nih.gov)
- At high levels, inorganic arsenic can cause death. (cdc.gov)
- Living in areas with unusually high natural levels of arsenic in rock. (cdc.gov)
- Breathing high levels of inorganic arsenic can give you a sore throat or irritated lungs. (cdc.gov)
- Ingesting very high levels of arsenic can result in death. (cdc.gov)
- Ingesting or breathing low levels of inorganic arsenic for a long time can cause a darkening of the skin and the appearance of small "corns" or "warts" on the palms, soles, and torso. (cdc.gov)
- ED tested 49 common items used as makeup in search for the presence and levels of eight heavy metals, including lead and arsenic. (lawyersandsettlements.com)
- Arsenic poisoning, or arsenicosis, occurs after the ingestion or inhalation of high levels of arsenic. (healthline.com)
- Countries that have high levels of arsenic-containing groundwater include the United States, India, China, and Mexico. (healthline.com)
- Still, knowing whether you have high levels of arsenic in the body can help you make changes to your lifestyle, if needed. (healthline.com)
- Keurig Dr Pepper Inc. KDP, -0.44% said late Friday it is recalling its Peñafiel bottled water, imported from Mexico, due to arsenic levels that exceed standards. (marketwatch.com)
- Water quality tests of Peñafiel samples conducted by an independent laboratory on behalf of Keurig Dr Pepper detected arsenic at levels that exceeded the FDA's bottled water standards for mineral water of 10 (parts per billion)," the company said. (marketwatch.com)
- However, scientists have published articles warning that average arsenic levels in chicken meat may be higher than previously thought. (upc-online.org)
- High Levels of Arsenic Found in Chicken," an article published by Environment News Service, Bethesda, Maryland, January 20, 2004, stated that arsenic concentrations in young chickens are three times greater than in other meat and poultry products, according to a US government science report in the January issue of "Environmental Health Perspectives. (upc-online.org)
- At average levels of chicken consumption - 2 ounces a day, or the equivalent of a third to half of a boneless chicken breast - people ingest about 3.6 to 5.2 micrograms of inorganic arsenic, the most toxic form of arsenic. (upc-online.org)
- Abstract: Abstract: DESCRIPTION (provided by applicant): Millions of people in the U.S. and worldwide are exposed to unsafe levels of inorganic arsenic (iAs) in drinking water. (nih.gov)
- that noted that there was arsenic in apple juice, claiming that his tests found high levels of arsenic in "some of the nation's best known brands of apple juice. (gothamist.com)
- High levels of arsenic can also build up as a result of human activities, such as mining, farming, and other industries. (nih.gov)
- Here's the good news: it's very unlikely that you'll be exposed to dangerous levels unless your job involves regular contact with arsenic (for example, if you work with certain metals or wood). (nih.gov)
- Breathing in high levels of arsenic can cause a sore throat and irritation of the lungs. (nih.gov)
- If the arsenic levels are extremely high in the leaves, the plants are disposed of at a hazardous waste facility. (genomenewsnetwork.org)
- Roughly one-third of the tested products, 40 in total, had high enough levels of arsenic, lead, and cadmium combined, on average, to pose a health concern for children when regularly consumed in typical serving sizes. (nbcdfw.com)
- As part of its announcement, the FDA said the arsenic levels are low and represent no meaningful risk to those eating Roxarsone-treated chicken - a point predictably emphasized by the National Chicken Council. (grist.org)
- Arsenic levels at a former mining site in the Tamar Valley are posing a health risk to employees and the public using the site, a new study suggests. (plymouth.ac.uk)
- So it is extremely concerning to see arsenic concentrations above safe levels right across an area now used so extensively by people of all ages, with just one of our 98 sample sites being below the UK guideline values for recreational sites, such as parkland. (plymouth.ac.uk)
Pure arsenic1
- The searches on YouTube and Google included: "how many grams of pure arsenic will kill a human," "Is Arsenic Detectable in Autopsy," "Top 5 Undetectable Poisons That Show No Signs of Foul Play," "how to make poison," and "The Top 10 Deadliest Plants (They Can Kill You)," according to the affidavit. (timescall.com)
Remove arsenic5
- Rain and snow remove arsenic dust particles from the air. (cdc.gov)
- Today, the ferns are being used throughout the United States to remove arsenic from soil and drinking water. (genomenewsnetwork.org)
- This summer 2,800 edenferns are being planted in the nation's capital as part of a pilot project to remove arsenic from 600 acres near American University in the Northwest part of Washington, D.C. The area, called Spring Valley, includes residential and university property. (genomenewsnetwork.org)
- The ferns are also being used to remove arsenic from drinking water. (genomenewsnetwork.org)
- New strategies are needed to remove arsenic from drinking water cheaply and effectively for big and small cities in the United States. (genomenewsnetwork.org)
Ingestion2
Humans3
- The International Agency for Research on Cancer (IARC) has determined that inorganic arsenic is carcinogenic to humans. (cdc.gov)
- Studies in cell culture show that arsenic causes degradation of CFTR, and our recent epidemiological study demonstrates that humans exposed to arsenic also exhibit CFTR dysfunction. (nih.gov)
- The standard was set for a reason, and the reason is that arsenic is known to cause cancer in humans," said Dr. Gina Solomon, with the Natural Resources Defense Council. (prisonlegalnews.org)
CATION1
- Your search for ARSENIC CATION 3 did not return any results. (nih.gov)
Detectable2
- Minneapolis, Minnesota-based IATP tested 155 samples from raw supermarket chicken products and found that 55 percent carried detectable arsenic. (upc-online.org)
- All 90 fast food chicken products tested by IATP also contained detectable arsenic. (upc-online.org)
Water25
- Arsenic in drinking water is a widespread concern. (nih.gov)
- There is particular concern for infants and children exposed to arsenic in water and some foods during their development. (nih.gov)
- The most common source of inorganic arsenic is contaminated drinking water. (nih.gov)
- 1 The U.S. Geological Survey studies sources of arsenic to help local health officials better manage water resources. (nih.gov)
- Arsenic can get into air, water, and the ground from wind-blown dust. (medlineplus.gov)
- Most of the arsenic in water will ultimately end up in soil or sediment. (cdc.gov)
- Thus, you usually cannot tell if arsenic is present in your food, water, or air. (cdc.gov)
- Thus, arsenic can get into lakes, rivers, or underground water by dissolving in rain or snow or through the discharge of industrial wastes. (cdc.gov)
- Some of the arsenic will stick to particles in the water or sediment on the bottom of lakes or rivers, and some will be carried along by the water. (cdc.gov)
- Drinking arsenic-laden water over a long period of time can lead to poisoning. (healthline.com)
- People can be exposed to (come in contact with) arsenic when it gets into food, water, and air. (nih.gov)
- In a recent pilot study in Albuquerque, New Mexico, the ferns significantly decreased the level of arsenic in samples of the city's drinking water. (genomenewsnetwork.org)
- Under the Safe Water Drinking Act, the Environmental Protection Agency recently revised the standards for allowable limits of arsenic in drinking water. (genomenewsnetwork.org)
- In addition to the United States, the ferns could be used in small communities in developing countries such as Bangladesh, which has problems with arsenic in drinking water. (genomenewsnetwork.org)
- Typical arsenic concentrations are 2 to 5 parts per billion in soil and sea water. (nih.gov)
- In the United States, the maximal allowable concentration of arsenic in well and drinking water is 50 parts per billion. (nih.gov)
- When people think about heavy metals in their diet, if they do at all, it's probably the lead in their drinking water or arsenic in their children's fruit juices or cereals," Rogers says. (nbcdfw.com)
- Indeed, "arsenic in poultry manure is rapidly converted into an inorganic form that is highly water soluble and capable of moving into surface and ground water," write Keeve E. Nachman and Robert S. Lawrence of the Johns Hopkins Center for a Livable Future. (grist.org)
- Other prisoners' families have gotten involved, including Blanca Gonzalez, who collected around 2,000 signatures on a petition demanding that prison officials take action to address the facility's arsenic-laced water. (prisonlegalnews.org)
- Public health concerns about arsenic in drinking water related to its potential to cause adverse health effects are addressed through the adoption of state and federal drinking water standards, also called maximum contaminant level (MCLs). (ca.gov)
- The PHG is 0.004 μg/L, based on lung and urinary bladder cancer risk, corresponding to a de minimis cancer risk level (i.e., up to one excess case of cancer per million people per 70-year lifetime, if their drinking water contained arsenic at the concentration of the PHG). (ca.gov)
- Arsenic is ubiquitous in nature and is commonly found in drinking water sources in California. (ca.gov)
- The Division of Water Quality's GAMA Program, in its Groundwater Information Sheet for Arsenic (PDF) , has a map of arsenic detection, based on monitoring information from DDW's water quality monitoring database . (ca.gov)
- Information about drinking water quality (including arsenic and other contaminants) in specific drinking water supplies is available from DDW's Drinking Water Watch website. (ca.gov)
- Public water systems seeking assistance for arsenic-related projects should be aware of funding opportunities for water systems , some of which may be available for such projects. (ca.gov)
Poison7
- Arsenic: a beneficial therapeutic poison - a historical overview. (nih.gov)
- An Aurora dentist bought arsenic and cyanide days before his wife was poisoned to death, searched online about how to poison someone and was having an affair, police alleged in his arrest affidavit. (timescall.com)
- Sometimes, they're looking for poison - and it could be arsenic. (nih.gov)
- If you think someone has arsenic poisoning, call the Poison Control Center at (800) 222-1222 right away. (nih.gov)
- Arsenic is a nonessential trace element and well known poison that is found widely in low concentrations in the environment. (nih.gov)
- When some people hear the word "arsenic," they immediately think of poison. (nih.gov)
- Arsenic has been known as a poison and medicine for more than 2,000 years. (nih.gov)
Dust particles1
- Scientists also collected air samples at the site, with the average concentration of arsenic in dust particles exceeding that found generally in the atmosphere by more than 30 times. (plymouth.ac.uk)
Concentration2
- A significantly high arsenic concentration (p blood samples with maximum concentration 389 µg/L in GBC cases in comparison to control. (bvsalud.org)
- Similarly, in the gallbladder cancer patients , there was significantly high arsenic concentration observed in gallbladder tissue with highest concentration of 2166 µg/kg, in gallbladder stones 635 µg/kg, in bile samples 483 µg/L and in hair samples 6980 µg/kg respectively. (bvsalud.org)
Groundwater3
- Contaminated groundwater is the most common cause of arsenic poisoning. (healthline.com)
- Arsenic is already present in the earth and can seep into groundwater. (healthline.com)
- At some point, however, this arsenic could become mobilized and contaminate surface and groundwater. (upc-online.org)
Contamination2
- Meanwhile, Scott Kernan, undersecretary of operations for California's prison system, has set another deadline for resolving the arsenic contamination at Kern Valley. (prisonlegalnews.org)
- The findings do provide a strong link between arsenic contamination and increased gallbladder carcinogenesis . (bvsalud.org)
Particles3
- Arsenic released from power plants and other combustion processes is usually attached to very small particles. (cdc.gov)
- Arsenic contained in wind-borne soil is generally found in larger particles. (cdc.gov)
- Arsenic that is attached to very small particles may stay in the air for many days and travel long distances. (cdc.gov)
Symptoms1
- Short-term arsenic poisoning can cause unpleasant symptoms, but the outlook remains good overall. (healthline.com)
Harmful2
- most of this arsenic is in an organic form called arsenobetaine that is much less harmful. (cdc.gov)
- Although some fish and shellfish take in arsenic, which may build up in tissues, most of this arsenic is in an organic form called arsenobetaine (commonly called "fish arsenic") that is much less harmful. (cdc.gov)
High2
- Simultaneous reflection high-energy electron diffraction (RHEED) oscillations measured during epitaxy are used to quantify the arsenic and gallium fluxes. (nist.gov)
- The study denotes that the gallbladder disease burden is very high in the arsenic exposed area of Bihar. (bvsalud.org)
Lungs1
- Samples from the site were also taken back to the laboratory and placed in solutions designed to simulate those found in human lungs and stomach, with the results showing that target values for arsenic were exceeded in many cases, even when considering the biologically accessible proportion of the element. (plymouth.ac.uk)
Found7
- Arsenic is a natural element found in soil and minerals. (medlineplus.gov)
- Arsenic has been found in at least 1,149 of the 1,684 National Priority List sites identified by the Environmental Protection Agency (EPA). (cdc.gov)
- However, arsenic is usually found in the environment combined with other elements such as oxygen, chlorine, and sulfur. (cdc.gov)
- The same lip gloss also was found to contain 70 ppm of arsenic, compared with a proposed limit of 3 ppm deemed safe for use. (lawyersandsettlements.com)
- According to the Associated Press , the FDA has confirmed that chickens given the drug (frequently those destined for the low-cost supermarket shelf) do indeed test positive for inorganic arsenic - just as the Institute for Agriculture and Trade Policy found [PDF] back in 2006. (grist.org)
- A December 2008 order issued by the California Department of Public Health found a "violation of the arsenic maximum containment level" at the prison. (prisonlegalnews.org)
- Few people might be aware of it, but arsenic can be found in lots of food items. (komando.com)
Chronic1
- Strategies for safe and effective therapeutic measures for chronic arsenic and lead poisoning. (nih.gov)
Exposures1
- Scientists, pediatricians, and public health professionals are concerned about subtle and long-range health effects of low-level exposures to arsenic in people. (nih.gov)
Breathing1
- Swallowing or breathing in a lot of arsenic may even cause death. (nih.gov)
Redness1
- Skin contact with inorganic arsenic may cause redness and swelling. (cdc.gov)
Nonessential trace element1
- Arsenic is a nonessential trace element that is widely distributed in nature. (nih.gov)
Inhalation1
- Inhalation of inorganic arsenic can cause increased risk of lung cancer. (cdc.gov)
Carbon3
- Organic - In this case, the term simply means the arsenic compound contains carbon. (nih.gov)
- Arsenic combined with carbon and hydrogen is referred to as organic arsenic. (cdc.gov)
- Organic" in the chemistry sense, that is, not the agricultural sense - i.e., molecules containing carbon atoms as well as arsenic. (grist.org)
Copper3
- Working in a job that involves arsenic production or use, such as copper or lead smelting, wood treating, or pesticide application. (cdc.gov)
- Arsenic is associated with ores containing metals, such as copper and lead. (cdc.gov)
- The Devon Great Consols, part of the Cornwall and West Devon Mining Landscape UNESCO World Heritage Site, was mined extensively in the 19th century for copper and arsenic. (plymouth.ac.uk)
Organic form2
- Arsenic feed additives, like Roxarsone (4-hydroxy-3-nitrophenyl arsenic acid), are in an organic form. (upc-online.org)
- The industry emphasizes that the arsenic is applied in organic form, which isn't immediately toxic. (grist.org)