Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
Irregular HEART RATE caused by abnormal function of the SINOATRIAL NODE. It is characterized by a greater than 10% change between the maximum and the minimum sinus cycle length or 120 milliseconds.
Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).
Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.
The hollow, muscular organ that maintains the circulation of the blood.
Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)
The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat).
An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).
Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.
A potentially lethal cardiac arrhythmia that is characterized by uncoordinated extremely rapid firing of electrical impulses (400-600/min) in HEART VENTRICLES. Such asynchronous ventricular quivering or fibrillation prevents any effective cardiac output and results in unconsciousness (SYNCOPE). It is one of the major electrocardiographic patterns seen with CARDIAC ARREST.
Surgery performed on the heart.
Regulation of the rate of contraction of the heart muscles by an artificial pacemaker.
An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.
The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A type of cardiac arrhythmia with premature contractions of the HEART VENTRICLES. It is characterized by the premature QRS complex on ECG that is of abnormal shape and great duration (generally >129 msec). It is the most common form of all cardiac arrhythmias. Premature ventricular complexes have no clinical significance except in concurrence with heart diseases.
Method in which prolonged electrocardiographic recordings are made on a portable tape recorder (Holter-type system) or solid-state device ("real-time" system), while the patient undergoes normal daily activities. It is useful in the diagnosis and management of intermittent cardiac arrhythmias and transient myocardial ischemia.
Abnormally rapid heartbeat, usually with a HEART RATE above 100 beats per minute for adults. Tachycardia accompanied by disturbance in the cardiac depolarization (cardiac arrhythmia) is called tachyarrhythmia.
Pathological conditions involving the HEART including its structural and functional abnormalities.
A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.
A group of cardiac arrhythmias in which the cardiac contractions are not initiated at the SINOATRIAL NODE. They include both atrial and ventricular premature beats, and are also known as extra or ectopic heartbeats. Their frequency is increased in heart diseases.
Contractile activity of the MYOCARDIUM.
Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Cessation of heart beat or MYOCARDIAL CONTRACTION. If it is treated within a few minutes, heart arrest can be reversed in most cases to normal cardiac rhythm and effective circulation.
Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.
Elements of limited time intervals, contributing to particular results or situations.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.
NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).
A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.
Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.
Compression of the heart by accumulated fluid (PERICARDIAL EFFUSION) or blood (HEMOPERICARDIUM) in the PERICARDIUM surrounding the heart. The affected cardiac functions and CARDIAC OUTPUT can range from minimal to total hemodynamic collapse.
The chambers of the heart, to which the BLOOD returns from the circulation.
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
A generic expression for any tachycardia that originates above the BUNDLE OF HIS.
Ultrasonic recording of the size, motion, and composition of the heart and surrounding tissues. The standard approach is transthoracic.
Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.
A condition in which HEART VENTRICLES exhibit impaired function.
Removal of tissue with electrical current delivered via electrodes positioned at the distal end of a catheter. Energy sources are commonly direct current (DC-shock) or alternating current at radiofrequencies (usually 750 kHz). The technique is used most often to ablate the AV junction and/or accessory pathways in order to interrupt AV conduction and produce AV block in the treatment of various tachyarrhythmias.
Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).
A voltage-gated sodium channel subtype that mediates the sodium ion PERMEABILITY of CARDIOMYOCYTES. Defects in the SCN5A gene, which codes for the alpha subunit of this sodium channel, are associated with a variety of CARDIAC DISEASES that result from loss of sodium channel function.
Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
An electrical current applied to the HEART to terminate a disturbance of its rhythm, ARRHYTHMIAS, CARDIAC. (Stedman, 25th ed)
The study of the electrical activity and characteristics of the HEART; MYOCARDIUM; and CARDIOMYOCYTES.
The hemodynamic and electrophysiological action of the left HEART VENTRICLE. Its measurement is an important aspect of the clinical evaluation of patients with heart disease to determine the effects of the disease on cardiac performance.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Cardiac arrhythmias that are characterized by excessively slow HEART RATE, usually below 50 beats per minute in human adults. They can be classified broadly into SINOATRIAL NODE dysfunction and ATRIOVENTRICULAR BLOCK.
Visualization of the heart structure and cardiac blood flow for diagnostic evaluation or to guide cardiac procedures via techniques including ENDOSCOPY (cardiac endoscopy, sometimes refered to as cardioscopy), RADIONUCLIDE IMAGING; MAGNETIC RESONANCE IMAGING; TOMOGRAPHY; or ULTRASONOGRAPHY.
A potent anti-arrhythmia agent, effective in a wide range of ventricular and atrial ARRHYTHMIAS and TACHYCARDIAS.
Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART.) Reperfusion takes place when there is spontaneous thrombolysis, THROMBOLYTIC THERAPY, collateral flow from other coronary vascular beds, or reversal of vasospasm.
A form of CARDIAC MUSCLE disease that is characterized by ventricular dilation, VENTRICULAR DYSFUNCTION, and HEART FAILURE. Risk factors include SMOKING; ALCOHOL DRINKING; HYPERTENSION; INFECTION; PREGNANCY; and mutations in the LMNA gene encoding LAMIN TYPE A, a NUCLEAR LAMINA protein.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
A malignant form of polymorphic ventricular tachycardia that is characterized by HEART RATE between 200 and 250 beats per minute, and QRS complexes with changing amplitude and twisting of the points. The term also describes the syndrome of tachycardia with prolonged ventricular repolarization, long QT intervals exceeding 500 milliseconds or BRADYCARDIA. Torsades de pointes may be self-limited or may progress to VENTRICULAR FIBRILLATION.
An antianginal and class III antiarrhythmic drug. It increases the duration of ventricular and atrial muscle action by inhibiting POTASSIUM CHANNELS and VOLTAGE-GATED SODIUM CHANNELS. There is a resulting decrease in heart rate and in vascular resistance.
Precursor cells destined to differentiate into cardiac myocytes (MYOCYTES, CARDIAC).
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Cyclopentanophenanthrenes with a 5- or 6-membered lactone ring attached at the 17-position and SUGARS attached at the 3-position. Plants they come from have long been used in congestive heart failure. They increase the force of cardiac contraction without significantly affecting other parameters, but are very toxic at larger doses. Their mechanism of action usually involves inhibition of the NA(+)-K(+)-EXCHANGING ATPASE and they are often used in cell biological studies for that purpose.
A state of subnormal or depressed cardiac output at rest or during stress. It is a characteristic of CARDIOVASCULAR DISEASES, including congenital, valvular, rheumatic, hypertensive, coronary, and cardiomyopathic. The serious form of low cardiac output is characterized by marked reduction in STROKE VOLUME, and systemic vasoconstriction resulting in cold, pale, and sometimes cyanotic extremities.
A conical fibro-serous sac surrounding the HEART and the roots of the great vessels (AORTA; VENAE CAVAE; PULMONARY ARTERY). Pericardium consists of two sacs: the outer fibrous pericardium and the inner serous pericardium. The latter consists of an outer parietal layer facing the fibrous pericardium, and an inner visceral layer (epicardium) resting next to the heart, and a pericardial cavity between these two layers.
The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.
Impaired conduction of cardiac impulse that can occur anywhere along the conduction pathway, such as between the SINOATRIAL NODE and the right atrium (SA block) or between atria and ventricles (AV block). Heart blocks can be classified by the duration, frequency, or completeness of conduction block. Reversibility depends on the degree of structural or functional defects.
The hemodynamic and electrophysiological action of the HEART VENTRICLES.
Myosin type II isoforms found in cardiac muscle.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).
The abrupt cessation of all vital bodily functions, manifested by the permanent loss of total cerebral, respiratory, and cardiovascular functions.
Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.
Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).
The transference of a heart from one human or animal to another.
The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
A condition in which the LEFT VENTRICLE of the heart was functionally impaired. This condition usually leads to HEART FAILURE; MYOCARDIAL INFARCTION; and other cardiovascular complications. Diagnosis is made by measuring the diminished ejection fraction and a depressed level of motility of the left ventricular wall.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
Occurrence of heart arrest in an individual when there is no immediate access to medical personnel or equipment.
A family of voltage-gated potassium channels that are characterized by long N-terminal and C-terminal intracellular tails. They are named from the Drosophila protein whose mutation causes abnormal leg shaking under ether anesthesia. Their activation kinetics are dependent on extracellular MAGNESIUM and PROTON concentration.
The volume of the HEART, usually relating to the volume of BLOOD contained within it at various periods of the cardiac cycle. The amount of blood ejected from a ventricle at each beat is STROKE VOLUME.
Examinations used to diagnose and treat heart conditions.
Ion channels that specifically allow the passage of SODIUM ions. A variety of specific sodium channel subtypes are involved in serving specialized functions such as neuronal signaling, CARDIAC MUSCLE contraction, and KIDNEY function.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Drugs that bind to but do not activate beta-adrenergic receptors thereby blocking the actions of beta-adrenergic agonists. Adrenergic beta-antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety.
One of the three polypeptide chains that make up the TROPONIN complex. It inhibits F-actin-myosin interactions.
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
Recording of regional electrophysiological information by analysis of surface potentials to give a complete picture of the effects of the currents from the heart on the body surface. It has been applied to the diagnosis of old inferior myocardial infarction, localization of the bypass pathway in Wolff-Parkinson-White syndrome, recognition of ventricular hypertrophy, estimation of the size of a myocardial infarct, and the effects of different interventions designed to reduce infarct size. The limiting factor at present is the complexity of the recording and analysis, which requires 100 or more electrodes, sophisticated instrumentation, and dedicated personnel. (Braunwald, Heart Disease, 4th ed)
A transient loss of consciousness and postural tone caused by diminished blood flow to the brain (i.e., BRAIN ISCHEMIA). Presyncope refers to the sensation of lightheadedness and loss of strength that precedes a syncopal event or accompanies an incomplete syncope. (From Adams et al., Principles of Neurology, 6th ed, pp367-9)
Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
A 43-kDa peptide which is a member of the connexin family of gap junction proteins. Connexin 43 is a product of a gene in the alpha class of connexin genes (the alpha-1 gene). It was first isolated from mammalian heart, but is widespread in the body including the brain.
Transmission of the readings of instruments to a remote location by means of wires, radio waves, or other means. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The innermost layer of the heart, comprised of endothelial cells.
Isopropyl analog of EPINEPHRINE; beta-sympathomimetic that acts on the heart, bronchi, skeletal muscle, alimentary tract, etc. It is used mainly as bronchodilator and heart stimulant.
Tumors in any part of the heart. They include primary cardiac tumors and metastatic tumors to the heart. Their interference with normal cardiac functions can cause a wide variety of symptoms including HEART FAILURE; CARDIAC ARRHYTHMIAS; or EMBOLISM.
A type of cardiac arrhythmia with premature atrial contractions or beats caused by signals originating from ectopic atrial sites. The ectopic signals may or may not conduct to the HEART VENTRICLES. Atrial premature complexes are characterized by premature P waves on ECG which are different in configuration from the P waves generated by the normal pacemaker complex in the SINOATRIAL NODE.
Optical imaging techniques used for recording patterns of electrical activity in tissues by monitoring transmembrane potentials via FLUORESCENCE imaging with voltage-sensitive fluorescent dyes.
The artificial substitution of heart and lung action as indicated for HEART ARREST resulting from electric shock, DROWNING, respiratory arrest, or other causes. The two major components of cardiopulmonary resuscitation are artificial ventilation (RESPIRATION, ARTIFICIAL) and closed-chest CARDIAC MASSAGE.
An antiarrhythmia agent that is particularly effective in ventricular arrhythmias. It also has weak beta-blocking activity.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
The restoration of the sequential order of contraction and relaxation of the HEART ATRIA and HEART VENTRICLES by atrio-biventricular pacing.
One of the three polypeptide chains that make up the TROPONIN complex. It is a cardiac-specific protein that binds to TROPOMYOSIN. It is released from damaged or injured heart muscle cells (MYOCYTES, CARDIAC). Defects in the gene encoding troponin T result in FAMILIAL HYPERTROPHIC CARDIOMYOPATHY.
A tetrameric calcium release channel in the SARCOPLASMIC RETICULUM membrane of SMOOTH MUSCLE CELLS, acting oppositely to SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE. Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES.
Modified cardiac muscle fibers composing the terminal portion of the heart conduction system.
One of the ANTI-ARRHYTHMIA AGENTS, it blocks VOLTAGE-GATED SODIUM CHANNELS and slows conduction within the His-Purkinje system and MYOCARDIUM.
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
The 10th cranial nerve. The vagus is a mixed nerve which contains somatic afferents (from skin in back of the ear and the external auditory meatus), visceral afferents (from the pharynx, larynx, thorax, and abdomen), parasympathetic efferents (to the thorax and abdomen), and efferents to striated muscle (of the larynx and pharynx).
Potassium channel whose permeability to ions is extremely sensitive to the transmembrane potential difference. The opening of these channels is induced by the membrane depolarization of the ACTION POTENTIAL.
The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Institutions specializing in the care of patients with heart disorders.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
General or unspecified injuries to the heart.
A combination of congenital heart defects consisting of four key features including VENTRICULAR SEPTAL DEFECTS; PULMONARY STENOSIS; RIGHT VENTRICULAR HYPERTROPHY; and a dextro-positioned AORTA. In this condition, blood from both ventricles (oxygen-rich and oxygen-poor) is pumped into the body often causing CYANOSIS.
An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.
Impaired impulse conduction from HEART ATRIA to HEART VENTRICLES. AV block can mean delayed or completely blocked impulse conduction.
A voltage-gated potassium channel that is expressed primarily in the HEART.
The veins and arteries of the HEART.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Controlled physical activity which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used.
Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.
An optical isomer of quinine, extracted from the bark of the CHINCHONA tree and similar plant species. This alkaloid dampens the excitability of cardiac and skeletal muscles by blocking sodium and potassium currents across cellular membranes. It prolongs cellular ACTION POTENTIALS, and decreases automaticity. Quinidine also blocks muscarinic and alpha-adrenergic neurotransmission.
Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.
Inflammatory processes of the muscular walls of the heart (MYOCARDIUM) which result in injury to the cardiac muscle cells (MYOCYTES, CARDIAC). Manifestations range from subclinical to sudden death (DEATH, SUDDEN). Myocarditis in association with cardiac dysfunction is classified as inflammatory CARDIOMYOPATHY usually caused by INFECTION, autoimmune diseases, or responses to toxic substances. Myocarditis is also a common cause of DILATED CARDIOMYOPATHY and other cardiomyopathies.
A small nodular mass of specialized muscle fibers located in the interatrial septum near the opening of the coronary sinus. It gives rise to the atrioventricular bundle of the conduction system of the heart.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Antiarrhythmic agent pharmacologically similar to LIDOCAINE. It may have some anticonvulsant properties.
A class Ia antiarrhythmic drug that is structurally-related to PROCAINE.
The circulation of blood through the CORONARY VESSELS of the HEART.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The protein constituents of muscle, the major ones being ACTINS and MYOSINS. More than a dozen accessory proteins exist including TROPONIN; TROPOMYOSIN; and DYSTROPHIN.
The small mass of modified cardiac muscle fibers located at the junction of the superior vena cava (VENA CAVA, SUPERIOR) and right atrium. Contraction impulses probably start in this node, spread over the atrium (HEART ATRIUM) and are then transmitted by the atrioventricular bundle (BUNDLE OF HIS) to the ventricle (HEART VENTRICLE).
Abnormally rapid heartbeats originating from one or more automatic foci (nonsinus pacemakers) in the HEART ATRIUM but away from the SINOATRIAL NODE. Unlike the reentry mechanism, automatic tachycardia speeds up and slows down gradually. The episode is characterized by a HEART RATE between 135 to less than 200 beats per minute and lasting 30 seconds or longer.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Diversion of the flow of blood from the entrance of the right atrium directly to the aorta (or femoral artery) via an oxygenator thus bypassing both the heart and lungs.
A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.
An adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmias.
A congenital cardiomyopathy that is characterized by infiltration of adipose and fibrous tissue into the RIGHT VENTRICLE wall and loss of myocardial cells. Primary injuries usually are at the free wall of right ventricular and right atria resulting in ventricular and supraventricular arrhythmias.
Signal transduction mechanisms whereby calcium mobilization (from outside the cell or from intracellular storage pools) to the cytoplasm is triggered by external stimuli. Calcium signals are often seen to propagate as waves, oscillations, spikes, sparks, or puffs. The calcium acts as an intracellular messenger by activating calcium-responsive proteins.
Simple rapid heartbeats caused by rapid discharge of impulses from the SINOATRIAL NODE, usually between 100 and 180 beats/min in adults. It is characterized by a gradual onset and termination. Sinus tachycardia is common in infants, young children, and adults during strenuous physical activities.
Computer-assisted processing of electric, ultrasonic, or electronic signals to interpret function and activity.
Treatment process involving the injection of fluid into an organ or tissue.
Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.
A class I anti-arrhythmic agent (one that interferes directly with the depolarization of the cardiac membrane and thus serves as a membrane-stabilizing agent) with a depressant action on the heart similar to that of guanidine. It also possesses some anticholinergic and local anesthetic properties.
An electrogenic ion exchange protein that maintains a steady level of calcium by removing an amount of calcium equal to that which enters the cells. It is widely distributed in most excitable membranes, including the brain and heart.
The hemodynamic and electrophysiological action of the HEART ATRIA.
A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.
Drugs that selectively bind to and activate beta-adrenergic receptors.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Mature contractile cells, commonly known as myocytes, that form one of three kinds of muscle. The three types of muscle cells are skeletal (MUSCLE FIBERS, SKELETAL), cardiac (MYOCYTES, CARDIAC), and smooth (MYOCYTES, SMOOTH MUSCLE). They are derived from embryonic (precursor) muscle cells called MYOBLASTS.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
A widely used non-cardioselective beta-adrenergic antagonist. Propranolol has been used for MYOCARDIAL INFARCTION; ARRHYTHMIA; ANGINA PECTORIS; HYPERTENSION; HYPERTHYROIDISM; MIGRAINE; PHEOCHROMOCYTOMA; and ANXIETY but adverse effects instigate replacement by newer drugs.
The period of time following the triggering of an ACTION POTENTIAL when the CELL MEMBRANE has changed to an unexcitable state and is gradually restored to the resting (excitable) state. During the absolute refractory period no other stimulus can trigger a response. This is followed by the relative refractory period during which the cell gradually becomes more excitable and the stronger impulse that is required to illicit a response gradually lessens to that required during the resting state.
The continuous measurement of physiological processes, blood pressure, heart rate, renal output, reflexes, respiration, etc., in a patient or experimental animal; includes pharmacologic monitoring, the measurement of administered drugs or their metabolites in the blood, tissues, or urine.
The return of a sign, symptom, or disease after a remission.
Conical muscular projections from the walls of the cardiac ventricles, attached to the cusps of the atrioventricular valves by the chordae tendineae.
Recording the locations and measurements of electrical activity in the EPICARDIUM by placing electrodes on the surface of the heart to analyze the patterns of activation and to locate arrhythmogenic sites.
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
A form of ventricular pre-excitation characterized by a short PR interval and a long QRS interval with a delta wave. In this syndrome, atrial impulses are abnormally conducted to the HEART VENTRICLES via an ACCESSORY CONDUCTING PATHWAY that is located between the wall of the right or left atria and the ventricles, also known as a BUNDLE OF KENT. The inherited form can be caused by mutation of PRKAG2 gene encoding a gamma-2 regulatory subunit of AMP-activated protein kinase.
The mitochondria of the myocardium.
The excitable plasma membrane of a muscle cell. (Glick, Glossary of Biochemistry and Molecular Biology, 1990)
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
The veins that return the oxygenated blood from the lungs to the left atrium of the heart.
Acidic protein found in SARCOPLASMIC RETICULUM that binds calcium to the extent of 700-900 nmoles/mg. It plays the role of sequestering calcium transported to the interior of the intracellular vesicle.
A paravertebral sympathetic ganglion formed by the fusion of the inferior cervical and first thoracic ganglia.
A form of heart block in which the electrical stimulation of HEART VENTRICLES is interrupted at either one of the branches of BUNDLE OF HIS thus preventing the simultaneous depolarization of the two ventricles.
Calcium-transporting ATPases that catalyze the active transport of CALCIUM into the SARCOPLASMIC RETICULUM vesicles from the CYTOPLASM. They are primarily found in MUSCLE CELLS and play a role in the relaxation of MUSCLES.
A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.
The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.
Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Post-systolic relaxation of the HEART, especially the HEART VENTRICLES.
Compounds based on N-phenylacetamide, that are similar in structure to 2-PHENYLACETAMIDES. They are precursors of many other compounds. They were formerly used as ANALGESICS and ANTIPYRETICS, but often caused lethal METHEMOGLOBINEMIA.
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
The repeating contractile units of the MYOFIBRIL, delimited by Z bands along its length.
Refers to animals in the period of time just after birth.
A benign tumor derived from striated muscle. It is extremely rare, generally occurring in the tongue, neck muscles, larynx, uvula, nasal cavity, axilla, vulva, and heart. These tumors are treated by simple excision. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1354)
Flaps of tissue that prevent regurgitation of BLOOD from the HEART VENTRICLES to the HEART ATRIA or from the PULMONARY ARTERIES or AORTA to the ventricles.
A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Measurement of intracardiac blood flow using an M-mode and/or two-dimensional (2-D) echocardiogram while simultaneously recording the spectrum of the audible Doppler signal (e.g., velocity, direction, amplitude, intensity, timing) reflected from the moving column of red blood cells.
One of the minor protein components of skeletal muscle. Its function is to serve as the calcium-binding component in the troponin-tropomyosin B-actin-myosin complex by conferring calcium sensitivity to the cross-linked actin and myosin filaments.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
A general class of ortho-dihydroxyphenylalkylamines derived from tyrosine.
A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The electrical properties, characteristics of living organisms, and the processes of organisms or their parts that are involved in generating and responding to electrical charges.
A process fundamental to muscle physiology whereby an electrical stimulus or action potential triggers a myocyte to depolarize and contract. This mechanical muscle contraction response is regulated by entry of calcium ions into the cell.
Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.
An antiarrhythmia agent used primarily for ventricular rhythm disturbances.
The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).
One of two major pharmacologically defined classes of adrenergic receptors. The beta adrenergic receptors play an important role in regulating CARDIAC MUSCLE contraction, SMOOTH MUSCLE relaxation, and GLYCOGENOLYSIS.

Effect of electrotonic potentials on pacemaker activity of canine Purkinje fibers in relation to parasystole. (1/4675)

Isolated false tendons excised form dog hearts were mounted in a three-chamber tissue bath. Isotonic sucrose solution was perfused in the central chamber to provide a region of depressed conductivity between the fiber segments in chambers 1 and 3, which were perfused with Tyrode's solution. The electrotonic influence of spontaneous or driven responses evoked in chamber 3 during the first half of the spontaneous cycle of a chamber 1 peacemaker delayed the next spontaneous discharge. This effect changed to acceleration when the chamber 3 segment fired during the second half of the spontaneous cycle. We found that subthreshold depolarizing current pulses 50-300 msec applied across the sucrose gap caused similar degrees of delay or acceleration. Furthermore, hyperpolarizing currents caused the reverse pattern. The results indicate that the discharge pattern of a parasystolic focus may be altered by the electrotonic influence of activity in the surrounding tissue. The significance of these findings is considered in relation to the mechanism of production of parasystolic rhythms.  (+info)

Evaluation of the force-frequency relationship as a descriptor of the inotropic state of canine left ventricular myocardium. (2/4675)

The short-term force-frequency characteristics of canine left ventricular myocardium were examined in both isolated and intact preparations by briefly pertubing the frequency of contraction with early extrasystoles. The maximum rate of rise of isometric tension (Fmas) of the isolated trabeculae carneae was potentiated by the introduction of extrasystoles. The ratio of Fmas of potentiated to control beats (force-frequency ratio) was not altered significantly by a change in muscle length. However, exposure of the trabeculae to isoproterenol (10(-7)M) significantly changed the force-frequency ratio obtained in response to a constant frequency perturbation. Similar experiments were performed on chronically instrumented conscious dogs. Left ventricular minor axis diameter was measured with implanted pulse-transit ultrasonic dimension transducers, and intracavitary pressure was measured with a high fidelity micromanometer. Atrial pacing was performed so that the end-diastolic diameters of the beats preceding and following the extrasystole could be made identical. Large increases in the maximum rate of rise of pressure (Pmas) were seen in the contraction after the extrasystole. The ratio of Pmax of the potentiated beat to that of the control beat was not changed by a 9% increase in the end-diastolic diameter, produced by saline infusion. Conversely, isoproterenol significantly altered this relationship in the same manner as in the isolated muscle. Thus, either in vitro or in situ, left ventricular myocardium exhibits large functional changes in response to brief perturbations in rate. The isoproterenol and length data indicate that the force-frequency ratio reflects frequency-dependent changes in the inotropic state, independent of changes in length.  (+info)

Arterial blood gas tensions during upper gastrointestinal endoscopy. (3/4675)

Arterial blood gas tensions were measured before and during upper gastrointestinal endoscopy, with (group I) and without (group 2) sedation with intravenous diazepam. There was a highly significant fall in the PaO2, which occurred in both groups and was therefore not attributable to diazepam. Measurement of FEV, and FVC before endoscopy had no predictive value for those patients whose PaO2 fell the most.  (+info)

Bradykinin promotes ischemic norepinephrine release in guinea pig and human hearts. (4/4675)

We previously reported that bradykinin (BK; 1-1000 nM) facilitates norepinephrine (NE) release from cardiac sympathetic nerves. Because BK production increases in myocardial ischemia, endogenous BK could foster NE release and associated arrhythmias. We tested this hypothesis in guinea pig and human myocardial ischemia models. BK administration (100 nM) markedly enhanced exocytotic and carrier-mediated NE overflow from guinea pig hearts subjected to 10- and 20-min ischemia/reperfusion, respectively. Ventricular fibrillation invariably occurred after 20-min global ischemia; BK prolonged its duration 3-fold. The BK B2 receptor antagonist HOE140 (30 nM) blocked the effects of BK, whereas the B1 receptor antagonist des-Arg9-Leu8-BK (1 microM; i.e., 2.5 x pA2) did not. When serine proteinase inhibitors (500 KIU/ml aprotinin and 100 microg/ml soybean trypsin inhibitor) were used to prevent the formation of endogenous BK, NE overflow and reperfusion arrhythmias were diminished. In contrast, when kininase I and II inhibitors (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid and enalaprilat, each 1 microM) were used to prevent the degradation of endogenous BK, NE overflow and reperfusion arrhythmias were enhanced. B2 receptor blockade abolished these effects but was ineffective if kininases were not inhibited. B2 receptor stimulation, by either exogenous or endogenous BK, also markedly enhanced carrier-mediated NE release in the human myocardial ischemia model; conversely, inhibition of BK biosynthesis diminished ischemic NE release. Because atherosclerotic heart disease impairs endothelial BK production, in myocardial ischemia BK could accumulate at sympathetic nerve endings, thus augmenting exocytotic and carrier-mediated NE release and favoring coronary vasoconstriction and arrhythmias.  (+info)

Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. (5/4675)

AIM: To develop a cardiac hypertrophic model in rats. METHODS: Rats were i.p. levothyroxine 0.5 mg.kg-1.d-1 x 10 d. The action potentials of right papillary muscles were recorded by standard glass-microelectrode technique. The left coronary artery was ligated followed by reperfusion and the apparent infarcted zone (AIZ) was determined by tetracycline fluoresence, and the superoxide dismutase (SOD) activity and malondialdehyde (MDA) product in myocardium were also measured. RESULTS: In the rats treated by levothyroxine, the heart was hypertrophic and the action potential duration (APD) and effective refractory period (ERP) were prolonged, the APD20, APD50, APD90, and ERP were prolonged by 80%, 79%, 74%, and 68%, respectively. No changes in resting potential (RP), action potential amplitude (APA), and Vmax were produced. The incidence of heart arrest (8/8) and the risk of death (67 +/- 0) induced by ischemia-reperfusion in rats with hypertrophic heart was higher than those in normal rats (4/10 and 44 +/- 19, respectively). The AIZ was expanded markedly in hypertrophic heart, and attenuated by lidocaine and propranolol. CONCLUSION: Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats.  (+info)

Cardioprotection by opening of the K(ATP) channel in unstable angina. Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revascularization. (6/4675)

AIMS: To assess the anti-ischaemic and anti-arrhythmic effects and overall safety of nicorandil, an ATP sensitive potassium (K+) channel opener, with 'cardioprotective' effects, in patients with unstable angina. METHODS: In a multicentre, randomized, double-blind, parallel-group, placebo-controlled study, oral nicorandil 20 mg twice daily or a matching placebo was administered for a minimum of 48 h to patients admitted with unstable angina. Treatment was standardized to include, where tolerated, oral aspirin, a beta-blocker and diltiazem. Continuous Holter ECG monitoring was performed for 48 h to assess the frequency and duration of transient myocardial ischaemia and any tachyarrhythmia, as the predefined end-points of the study. A pain chart recorded the incidence and severity of chest pain throughout the study period. Patients with myocardial infarction identified retrospectively from troponin-T analysis were excluded. RESULTS: Two hundred and forty-five patients were recruited into the study. Forty-three patients were excluded with an index diagnosis of myocardial infarction, two were not randomized and 12 had unsatisfactory tape data. In the remaining 188 patients, six out of 89 patients (6.7%) on nicorandil experienced an arrhythmia, compared with 17 out of 99 patients (17.2%) on placebo (P=0.04). Three nicorandil patients experienced three runs of non-sustained ventricular tachycardia compared to 31 runs in 10 patients on placebo (P=0.087 patients; P<0.0001 runs). Three nicorandil patients had four runs of supraventricular tachycardia, compared to 15 runs in nine patients on placebo (P=0.14 patients; P=0.017 runs). Eleven (12.4%) patients on nicorandil had 37 episodes of transient myocardial ischaemia (mostly silent) compared with 74 episodes in 21 (21.2%) patients on placebo (P=0.12 patients; P=0.0028 episodes). In the overall safety analysis, which included all patients who received at least one dose of study medication, there were no significant differences in the rates of myocardial infarction or death between the nicorandil or placebo-treated groups. CONCLUSIONS: Nicorandil, added to aggressive anti-anginal treatment for unstable angina, reduces transient myocardial ischaemia, non-sustained ventricular, and supraventricular arrhythmia compared to placebo. The anti-arrhythmic activity with nicorandil is probably a secondary effect resulting from its anti-ischaemic action and we suggest that this may be related to its effect on the ATP sensitive potassium channel causing pharmacological preconditioning.  (+info)

Superiority of ibutilide (a new class III agent) over DL-sotalol in converting atrial flutter and atrial fibrillation. The Ibutilide/Sotalol Comparator Study Group. (7/4675)

OBJECTIVE: To compare the efficacy and safety of a single dose of ibutilide, a new class III antiarrhythmic drug, with that of DL-sotalol in terminating chronic atrial fibrillation or flutter in haemodynamically stable patients. DESIGN: Double blind, randomised study. SETTING: 43 European hospitals. PATIENTS: 308 patients (mean age 60 years, 70% men, 48% with heart disease) with sustained atrial fibrillation (n = 251) or atrial flutter (n = 57) (duration three hours to 45 days) were randomised to three groups to receive a 10 minute infusion of 1 mg ibutilide (n = 99), 2 mg ibutilide (n = 106), or 1.5 mg/kg DL-sotalol (n = 103). Infusion was discontinued at termination of the arrhythmia. MAIN OUTCOME MEASURE: Successful conversion of atrial fibrillation or flutter, defined as termination of arrhythmia within one hour of treatment. RESULTS: Both drugs were more effective against atrial flutter than against atrial fibrillation. Ibutilide was superior to DL-sotalol for treating atrial flutter (70% and 56% v 19%), while the high dose of ibutilide was more effective for treating atrial fibrillation than DL-sotalol (44% v 11%) and the lower dose of ibutilide (44% v 20%, p < 0.01). The mean (SD) time to arrhythmia termination was 13 (7) minutes with 2 mg ibutilide, 19 (15) minutes with 1 mg ibutilide, and 25 (17) minutes with DL-sotalol. In all patients, the duration of arrhythmia before treatment was a predictor of arrhythmia termination, although this was less obvious in the group that received 2 mg ibutilide. This dose converted almost 48% of atrial fibrillation that was present for more than 30 days. Concomitant use of digitalis or nifedipine and prolongation of the QTc interval were not predictive of arrhythmia termination. Bradycardia (6.5%) and hypotension (3.7%) were more common side effects with DL-sotalol. Of 211 patients given ibutilide, two (0.9%) who received the higher dose developed polymorphic ventricular tachycardia, one of whom required direct current cardioversion. CONCLUSION: Ibutilide (given in 1 or 2 mg doses over 10 minutes) is highly effective for rapidly terminating persistent atrial fibrillation or atrial flutter. This new class III drug, under monitored conditions, is a potential alternative to currently available cardioversion options.  (+info)

Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes. (8/4675)

The high incidence of sudden death in heart failure may reflect abnormalities of repolarization and heightened susceptibility to arrhythmogenic early afterdepolarizations (EADs). We hypothesized that overexpression of the human K+ channel HERG (human ether-a-go-go-related gene) could enhance repolarization and suppress EADs. Adult rabbit ventricular myocytes were maintained in primary culture, which suffices to prolong action potentials and predisposes to EADs. To achieve efficient gene transfer, we created AdHERG, a recombinant adenovirus containing the HERG gene driven by a Rous sarcoma virus (RSV) promoter. The virally expressed HERG current exhibited pharmacologic and kinetic properties like those of native IKr. Transient outward currents in AdHERG-infected myocytes were similar in magnitude to those in control cells, while stimulated action potentials (0.2 Hz, 37 degrees C) were abbreviated compared with controls. The occurrence of EADs during a train of action potentials was reduced by more than fourfold, and the relative refractory period was increased in AdHERG-infected myocytes compared with control cells. Gene transfer of delayed rectifier potassium channels represents a novel and effective strategy to suppress arrhythmias caused by unstable repolarization.  (+info)

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cardiac arrhythmia - MedHelps cardiac arrhythmia Center for Information, Symptoms, Resources, Treatments and Tools for cardiac arrhythmia. Find cardiac arrhythmia information, treatments for cardiac arrhythmia and cardiac arrhythmia symptoms.
About 20 years ago, the first traditional cardiac EP devices were designed and they were meant for treating less complex arrhythmias. As it became more and more obvious that there is an actual need for a device that can read more complex arrhythmias, savvy businessman Ken Londoner decided to invest in developing a system that can treat atrial fibrillation and ventricular tachyarrhythmia, and thus help millions of people. Today, not only have they developed a device that is able to read more complex arrhythmias, but have also found a way to get rid of the non-biological noise. ...
Defibrillation is a treatment for life-threatening cardiac dysrhythmias, specifically ventricular fibrillation (VF) and non-perfusing ventricular tachycardia (VT). A defibrillator delivers a dose of electric current (often called a countershock) to the heart. This depolarizes a large amount of the heart muscle, ending the dysrhythmia. Subsequently, the bodys natural pacemaker in the sinoatrial node of the heart is able to re-establish normal sinus rhythm. In contrast to defibrillation, synchronized electrical cardioversion is an electrical shock delivered in synchrony to the cardiac cycle. Although the person may still be critically ill, cardioversion normally aims to end poorly perfusing cardiac dysrhythmias, such as supraventricular tachycardia. Defibrillators can be external, transvenous, or implanted (implantable cardioverter-defibrillator), depending on the type of device used or needed. Some external units, known as automated external defibrillators (AEDs), automate the diagnosis of ...
The AVID Study was a multicenter, randomized comparison of antiarrhythmic drug treatment (mostly amiodarone) and ICD implantation to manage patients resuscitated from life-threatening ventricular arrhythmias not due to transient or reversible causes. Eligible arrhythmias included 1) VF; 2) sustained ventricular tachycardia (VT) with syncope; and 3) sustained VT with an ejection fraction of ≤0.40, and symptoms suggestive of severe hemodynamic compromise. The trial design and primary end-point paper have been published (19,20). It is interesting to note that the location of index ventricular arrhythmia presentation was not a factor in eligibility for randomization. Each participating institution had approval from its Institutional Review Board for conduct of the study. All patients who underwent randomization gave written informed consent.. As part of the study design, a registry was maintained of all patients with sustained ventricular arrhythmias at each study site. It included not only ...
Arrhythmias that originate in the ventricular myocardium or His-Purkinje system include premature ventricular beats, ventricular tachycardias that can be sustained or nonsustained, and ventricular fibrillation. Arrhythmia may emerge from a focus of myocardial or Purkinje cells capable of automaticity, or triggered automaticity, or from reentry through areas of scar or a diseased Purkinje system. Ventricular arrhythmias are often associated with structural heart disease and are an important cause of sudden death (Chap. 327). They also occur in some structurally normal hearts, in which case they are usually benign. Evaluation and management are guided by the risk of arrhythmic death, which is assessed based on symptoms, type of arrhythmia, and associated underlying heart disease. ...
Title: Wrist and arm sensing technologies for cardiac arrhythmias detection in long term monitoringSummaryAbnormal heart rhythms are a...
Many cerebral strokes are due to undetected cardiac arrhythmias. Any rapid cardiac arrhythmia may induce neurological symptoms as hemiplegia, aphasia, or psychosis. Twenty-eight patients who developed neurological disturbances following various cardiac arrhythmias were carefully studied. Most of these were due to rapid atrial fibrillation or supraventricular tachycardia. Undetected bradycardia due to vagotonia was a common cause of transient episodes of unconsciousness.. The cerebral blood flow was measured in animals when cardiac arrhythmias were induced. It was noted that frequent premature systoles reduced the cerebral blood flow 7 to 12%. More frequent runs of premature systoles caused a greater reduction. Supraventricular ...
A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.
A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.
To evaluate the effects of hypertension on cardiac hypertrophy, on myocardial structure, and on ventricular arrhythmias, 27 3-month-old spontaneously hypertensive rats were treated with enalapril (10 mg/kg) daily for 11 months and compared with 26 untreated control rats. Systolic arterial pressure was significantly decreased in treated rats, and at the end of the experiment, it was 199 +/- 3 mm Hg (treated) versus 237 +/- 3 mm Hg (controls) (p less than 0.001). At this time, spontaneous arrhythmias and induced arrhythmias either by programmed electrical stimulation (train of stimuli +1 or 2 extrastimuli) or by trains of eight stimuli at decreasing coupling intervals were observed in isolated heart preparations. Comparing enalapril-treated and control rats, spontaneous arrhythmias (9 of 27 versus 20 of 26, respectively; p less than 0.01), programmed stimulation-induced arrhythmias (3 of 26 versus 12 of 23, respectively; p less than 0.01), and trains of stimuli-induced arrhythmias (4 of 26 versus ...
Background-Genetic predisposition to life-threatening cardiac arrhythmias such as in congenital long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) represent treatable causes of sudden cardiac death in young adults and children. Recently, mutations in calmodulin (CALM1, CALM2) have been associated with severe forms of LQTS and CPVT, with life-threatening arrhythmias occurring very early in life. Additional mutation-positive cases are needed to discern genotype-phenotype correlations associated with calmodulin mutations. Methods and Results-We employed conventional and next-generation sequencing approaches including exome analysis in genotype-negative LQTS probands. We identified five novel de novo missense mutations in CALM2 in three subjects with LQTS (p.N98S, p.N98I, p.D134H) and two subjects with clinical features of both LQTS and CPVT (p.D132E, p.Q136P). Age of onset of major symptoms (syncope or cardiac arrest) ranged from 1-9 years. Three of five ...
Objectives Our previous study shows that Microvolt T-wave alternans (MTWA) testing has significant value for the prediction of mortality or severe arrhythmic events in a population of individuals with implanted ICDs. Whether MTWA is an accurate predictor of ventricular tachyarrhythmic events in patients without ICDs remains unclear. We conducted a meta-analysis of the predictive value of MTWA testing for mortality and severe arrhythmic events in patients with cardiac dysfunction but without implanted ICDs.. ...
Preliminary evidence supports an association between OSA and cardiac dysrhythmias. Negative intrathoracic pressure, as occurring during OSA, may provoke cardiac dysrhythmias. Thus, we aimed to study the acute effects of simulated apnea and hypopnea on arrhythmic potential and measures of cardiac
DESCRIPTION (provided by applicant): Implantable cardioverter defibrillators (ICDs) are medical devices proven to prevent sudden cardiac death due to ventricular arrhythmias. Their decisions are based solely upon the intra--?cardiac ECG. This is incomplete information since up to 1/3 of patients experience an inappropriate shock within the first 1-3 years of receiving the implant. Receiving a shock is associated with increased mortality as well as emotional trauma. In contrast, physicians determine whether to shock or medically convert a patient out of a rapid rhythm by determining if the arrhythmia is hemodynamically unstable or stable. An unstable arrhythmia is identified by decreased forward stroke volume (SV) and resultant low blood pressure (BP). A stable arrhythmia is identified by a forward SV or resultant BP close to the patients baseline. It would be ideal to have beat?by-beat SV available to the generator to assist in the determination of hemodynamic stability. Our group has developed ...
Clinical CharacteristicsThe Students t-test was used to compare the age, sex, height and weight, and initial blood pressure, heart rate, respiratory rate,
Cardiac arrhythmias are becoming one of the major health care problem in the world, causing numerous serious disease conditions including stroke and sudden cardiac death. Furthermore, cardiac arrhythmias are intimately related to the signaling ability of cardiac cells, and are caused by signaling defects. Consequently, modeling the electrical activity of the heart, and the complex signaling models that subtend dangerous arrhythmias such as tachycardia and fibrillation, necessitates a quantitative model of action potential (AP) propagation. Yet, many electrophysiological models, which accurately reproduce dynamical characteristic of the action potential in cells, have been introduced. However, these models are very complex and are very time consuming computationally. Consequently, a large amount of research is consecrated to design models with less computational complexity. This paper is presenting a new model for analyzing the propagation of ionic concentrations and electrical potential in space and
TY - JOUR. T1 - Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia. AU - Weng, Ching Hui. AU - Chung, Fa Po. AU - Chen, Yao Chang. AU - Lin, Shien Fong. AU - Huang, Po Hsun. AU - Kuo, Terry B J. AU - Hsu, Wei Hsuan. AU - Su, Cheng Wen. AU - Sung, Yen Ling. AU - Lin, Yenn Jiang. AU - Chang, Shih Lin. AU - Chou, Li Wei. AU - Yeh, Hung I.. AU - Chen, Yi-Jen. AU - Hong, Yi Ren. AU - Chen, Shih Ann. AU - Hu, Yu Feng. PY - 2016/12/14. Y1 - 2016/12/14. N2 - Observational studies have established a strong association between matrix metalloproteinase-9 (MMP-9) and ventricular arrhythmia. However, whether MMP-9 has a causal link to ventricular arrhythmia, as well as the underlying mechanism, remains unclear. Here, we investigated the mechanistic involvement of myocardial MMP-9 in the pathophysiology of ventricular arrhythmia. Increased levels of myocardial MMP-9 are linked to ventricular arrhythmia attacks after angiotensin II (Ang II) treatment. MMP-9-deficient mice were ...
Abstract: Recently, arrhythmogenic condition has attracted special attention of scientists in the field of different disciplines because sudden cardiac death is often caused by cardiac arrhythmia. Arrhythmias can have different underlying causes. But the underlying mechanism of arrhythmia is not fully understood due to cardiac complexity. As is well known, one particular group of arrhythmias is often associated with the afterdepolarizations. So far, afterdepolarizations have been studied mainly in isolated cardiac cells. The question how the afterdepolarization is produced at a tissue level has not been widely studied yet. In this paper, we use the model of human heart to study how spiral wave or other wave patterns induces the afterdepolarizations in two-dimensional myocardial tissue. We try to obtain the instantaneous spatial distribution of afterdepolarizations by changing the L-type calcium and fast potassium conductance. In order to avoid bringing in afterdepolarizations, the applied ...
Causes of Arrhythmias (Heart Rhythm Disturbances) can depend on each individual situation. Learn about causes of Arrhythmias (Heart Rhythm Disturbances) and find symptoms, diagnosis, and many types of smart treatments for Arrhythmias (Heart Rhythm Disturbances) at FoundHealth.
Sudden cardiac death (SCD) is responsible for 300,000-450,000 deaths per year in the United States. While it is well known that patients with both ischemic and non-ischemic cardiomyopathy (ICM, NICM) are at increased risk for SCD, there is little beyond ejection fraction which has proven useful as a noninvasive predictor to risk stratify these patients.. Myocardial scar has been validated as an arrhythmic substrate in ischemic populations; the majority of successful ablations for lethal ventricular arrhythmias are performed on tissues in peri-infarct regions. Scar provides an anatomic electrical boundary where peri-infarct zones may lead to areas of slow conduction due to the disruption of inter-myocyte electrical conduction.. Myocardial scar is a less organized collagen deposition which disrupts the typical cardiac extracellular matrix. The collagen matrix provides mechanical support to the myocardium dictating ventricular shape, size and stiffness. While typically relatively dormant, the ...
Sudden cardiac death (SCD) is responsible for 300,000-450,000 deaths per year in the United States. While it is well known that patients with both ischemic and non-ischemic cardiomyopathy (ICM, NICM) are at increased risk for SCD, there is little beyond ejection fraction which has proven useful as a noninvasive predictor to risk stratify these patients.. Myocardial scar has been validated as an arrhythmic substrate in ischemic populations; the majority of successful ablations for lethal ventricular arrhythmias are performed on tissues in peri-infarct regions. Scar provides an anatomic electrical boundary where peri-infarct zones may lead to areas of slow conduction due to the disruption of inter-myocyte electrical conduction.. Myocardial scar is a less organized collagen deposition which disrupts the typical cardiac extracellular matrix. The collagen matrix provides mechanical support to the myocardium dictating ventricular shape, size and stiffness. While typically relatively dormant, the ...
Sudden cardiac arrest (SCA) from ventricular arrhythmias affects over 400,000 individuals/year in the U.S. alone and has a dismal survival rate (1). Although reduced left ventricular systolic function (i.e., left ventricular ejection fraction) (2) and symptomatic heart failure (i.e., congestive heart failure) (3) are the major predictors of risk for SCA, they are more sensitive than they are specific. Thus, their primacy in guidelines for implantable cardioverter-defibrillators (ICDs) might lead to potentially unnecessary implantations (1). This motivates the identification of markers for the pathophysiology of ventricular arrhythmias that can improve indices for ICD insertion.. Several candidates exist. Inducing sustained ventricular arrhythmias at electrophysiologic study (EPS) was historically the gold standard but has become tarnished of late. Certainly, SCA is more frequent in ischemic cardiomyopathy patients with positive EPS, yet those with negative EPS still have a substantial arrhythmic ...
Arrhythmia. National Heart, Lung, and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/arrhythmia. Accessed January 4, 2019.. Atrial fibrillation. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115288/Atrial-fibrillation. Updated August 22, 2018. Accessed January 4, 2019.. Atrial flutter. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115251/Atrial-flutter. Updated February 22, 2017. Accessed January 4, 2019.. Atrioventricular (AV) conduction disorders. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T907302/Atrioventricular-AV-conduction-disorders. Updated November 27, 2017. Accessed January 4, 2019.. Understanding your risk for arrhythmia. American Heart Association website. Available at: https://www.heart.org/en/health-topics/arrhythmia/understand-your-risk-for-arrhythmia. Accessed January 4, 2019.. Ventricular arrhythmias. EBSCO DynaMed Plus website. Available ...
Diagnosing arrhythmia can be quite difficult because the medical condition may sometimes produce few symptoms. Many physicians diagnose an arrhythmia by examining the patients medical and family history and by performing physical examinations. To diagnose an arrhythmia, physicians usually ask patients to describe their symptoms. A physician may ask the patient if he or she feels thumping in his or her chest and whether the patient feels dizzy or lightheaded. A physician may also diagnose an arrhythmia by asking a patient if his or her family has a history of arrhythmia or other heart diseases. The doctor may ask the patient if he or she is under medications including over the counter medicines and supplements. A physical exam can also serve as an important diagnostic procedure for arrhythmia. During the physical exam, the doctor will examine the patients heart rate and rhythm, and the pulse to see if they are regular. He or she will also check for swelling in the legs or swelling in the feet, ...
Radiofreqeuncy Ablation therapy for arrhythmias caused by myocardial scar. Ablation Therapy for Arrhythmias and Cardiac Arrhythmias. Read about Ablation Therapy for Arrhythmias
Define Arrhythmias. Arrhythmias synonyms, Arrhythmias pronunciation, Arrhythmias translation, English dictionary definition of Arrhythmias. n. 1. An irregularity in the force or rhythm of the heartbeat: a fatal arrhythmia. 2. A condition characterized by such irregularities: treatments for...
The rate at which the heart beats is measured in beats per minute (or bpm) and is generally calculated over several RR intervals. The normal rate in an adult is between 50 and 120 bpm. However, it is natural for a healthy heart to beat at rates outside of this range when resting, exercising, or in response to other external factors and emotions.. Alterations in heart rhythm, arrhythmias, are heartbeats that are irregular, too fast, too slow, or conducted via an abnormal electrical pathway through the heart.. In common usage, the term dysrhythmia is synonymous with arrhythmia, although in the strictest sense, arrhythmia is the absence of cardiac rhythm and dysrhythmia is an abnormal cardiac rhythm.. The term bradyarrhythmia is used to define abnormally slow rhythms, either regular or irregular, or a slow ventricular response due to heart block.. Tachyarrhythmia describes arrhythmia characterised by a rapid irregular heartbeat.. Rhythms and arrhythmia are further classified by the site of the ...
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Ing Cardiac arrhythmia (mayayaus mu rin dysrhythmia) metung yang kataya kareng maragul at metung a lupang lupung a kabilyan nung nu atin epangkaraniwan ing kuryenting pangimut ning pusu. Ing pitig ning pusu malyaring mabilis ya o mabagal at neng misan ustu ya neng misan ali ya. Deng aliwang arrhythmias maliaring ikakamate dala at dapat idala da la keng medical emergencies at maliaring mikacardiac arrest la ampong biglaan ing pangamate da. Deng aliwa bala ra makabuysit mung symptomas. Deng aliwa naman makataid keng amanang at makamatengstroke o embolus. Deng aliwang arrhythmias maina la mu pinduan at maliari lang sabian a normal la. Ing tutu,deng aliwang tau panamdaman dang neng misan ing karelang pusu luksa ya keng kayang pitig, o neng misan naman mika masikan yang pitig nung nu dapat e dinan pagkabalisa.[1]. Ing katayang sinus arrhythmia daleraya ya keng pangkaraniwan a melayari nung nu bagyabagya ing pusu sinikad yang pasikan ampong pamangaina patse mangisnawang palub ampong palual. Keraklan ...
10.1055/b-0035-121513 18 Cardiac Arrhythmias 18.1 Antiarrhythmic Drugs 18.1.1 Basics Antiarrhythmic drugs play a central role in the treatment of cardiac arrhythmias in childhood. But their use must be weighed critically. There are numerous studies in adults showing that class I antiarrhythmic drugs do not reduce mortality, but even increase it in patients with ventricular tachycardia…
Looking for atrial arrhythmia? Find out information about atrial arrhythmia. disturbance in the rate or rhythm of the heartbeat. Various arrhythmias can be symptoms of serious heart heart, muscular organ that pumps blood to all parts... Explanation of atrial arrhythmia
Our data suggest that global and regional arrhythmia substrates change throughout different phases of resuscitation, and that temperature alters substrates differently throughout the phases of resuscitation. At normal temperatures, LAD occlusion increases VEBs, global DOR, and cardiac alternans. TH decreases VEBs, yet increases global DOR, and similarly promotes cardiac alternans. During this phase, temperature does not alter the end result of increased incidence of VT/VF. After ROSC from VF arrest, but still during LAD occlusion, there remains an increase in VEBs and cardiac alternans in CT, whereas global DOR returns to baseline. TH reduces VEBs, the increase in global DOR is no longer seen, and cardiac alternans is similarly increased. Again, the incidence of VT/VF is similarly increased in CT and TH. During LAD reperfusion, the incidence of VEBs and alternans in the CT group is greater than baseline, but global DOR returns to near baseline levels. TH markedly increases the magnitude of ...
Arrhythmia occurs when the hearts rhythm becomes disturbed or arrhythmic. The most common form of arrhythmia is a heart palpitation, known as sinus arrhythmia. More serious forms of heart arrhythmia include atrial fibrillation, ventricular tachycardia and ventricular fibrillation. Arrhythmia requires medical treatment; some rhythm disturbances are addressed through the use of medications, defibrillation, or a pacemaker. Natural options for heart support include fish oil, hawthorn, vitamin C and magnesium.
MedWorm- Cardiac Arrhythmia comments, Description: MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Cardiac Arrhythmia, ID: 284341, By: Feedage Forager
12-lead electrocardiogram is a vital component of electrophysiology workup for symptomatic palpitations and organic cardiac arrhythmias including supraventricular and ventricular arrhythmias.
This rare disease is characterized by episodic weakness, cardiac arrhythmias, and dysmorphic features (short stature, scoliosis, clinodactyly, hypertelorism, small or prominent low-set ears, micrognathia, and broad forehead). The cardiac arrhythmias are potentially serious and life threatening. They include long QT, ventricular ectopy, bidirectional ventricular arrhythmias, and tachycardia. For many years, the classification of this disorder was uncertain because episodes of weakness are associated with elevated, normal, or reduced levels of potassium during an attack. In addition, the potassium levels differ among kindreds but are consistent within a family. Inheritance is autosomal dominant, with incomplete penetrance and variable expressivity. The disease is caused by mutations of the inwardly rectifying potassium channel (Kir 2.1) gene that heighten muscle cell excitability. The treatment is similar to that for other forms of periodic paralysis and must include cardiac monitoring. The ...
This course covers cardiac electrical activity and the interpretation of electrocardiograms. The student echocardiographer develops skill in recognizing normal sinus rhythm versus atypical cardiac rhythms. Students learn to interpret common cardiac dysrhythmias, including sinus, atrial, junctional, and ventricular, and integrate this skill into the daily practice of echocardiography. The students will know the stress echo lab procedures including monitoring the patient. Students will learn to perform auscultation of the heart and lungs. Prerequisite: Acceptance into program, completion of DUTEC 155.. View details for DUTEC 200 ...
This course covers cardiac electrical activity and the interpretation of electrocardiograms. The student echocardiographer develops skill in recognizing normal sinus rhythm versus atypical cardiac rhythms. Students learn to interpret common cardiac dysrhythmias, including sinus, atrial, junctional, and ventricular, and integrate this skill into the daily practice of echocardiography. The students will know the stress echo lab procedures including monitoring the patient. Students will learn to perform auscultation of the heart and lungs. Prerequisite: Acceptance into program, completion of DUTEC 155.. View details for DUTEC 200 ...
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Palpitations (a perception of abnormal heartbeats) are a common complaint associated with abnormal heart rhythms. Fatigue, fainting, decreased stamina, shortness of breath and chest pain can also be associated with arrhythmias. Many young patients with arrhythmia have been misdiagnosed with anxiety or panic attacks for years.. How are arrhythmias diagnosed? How are they treated?. An arrhythmia is diagnosed by recording an abnormal heart rhythm with an electrocardiogram (EKG) or another form of heart monitor. Long-term or even implantable monitors are sometimes needed to catch infrequent arrhythmias. Treatment options can vary from lifestyle changes all the way up to heart surgery and other procedures. Many medications can also be used. Rhythm drugs- antiarrhythmics, should be used only under the supervision of a cardiologist because of their potential harm if improperly prescribed.. ...
An arrhythmia is a change in the rhythm of your heartbeat. When the heart beats too fast, its called tachycardia. When it beats too slow, its called bradycardia. An arrhythmia can also mean that your heart beats irregularly (skips a beat or has an extra beat). At some time or another, most people have felt their heart race or skip a beat.. Minor arrhythmias may be caused by excessive alcohol use, smoking, caffeine, stress or exercise. They usually are not a cause for alarm. Arrhythmias that occur more often or cause symptoms may be more serious and need to be discussed with your doctor.. ...
Cardiac arrhythmia is any of a large and heterogeneous group of conditions in which there is abnormal electrical activity in the heart. The heart beat may be too fast or too slow, and may be regular or irregular. A heart beat that is too fast is called tachycardia and a heart beat that is too slow is called bradycardia. Although many arrhythmias are not life-threatening, some can cause cardiac arrest. ...
ARVC is a hereditary heart condition in which the heart muscle (particularly the right ventricle) is partly replaced by fatty tissue and connective tissue. Cardiac arrhythmias can occur as a result of the changes in the heart muscle. Severe arrhythmias can cause dizziness or even lead to fainting or an acute cardiac arrest (= sudden death). ARVC is a progressive disease that usually presents during the teenage years.. Known mutations in desmosomal proteins ...
Learn more about Surgical Procedures for Arrhythmias (Heart Rhythm Disturbances) at Memorial Hospital Main Page Types of Arrhythmias ...
Learn more about Other Treatments for Arrhythmias (Heart Rhythm Disturbances) at Reston Hospital Center Main Page Types of Arrhythmias ...
Learn more about Conditions InDepth: Arrhythmias (Heart Rhythm Disturbances) at Doctors Hospital of Augusta Main Page Types of Arrhythmias ...
Mortality owing to iatrogenic hypoglycemia represents a major concern for insulin-treated diabetic patients and their families. Determining the mechanisms by which hypoglycemia causes sudden death is critically important in order to find treatment strategies that could protect at-risk patients. Based on ECG anomalies reported during moderate hypoglycemia (26), it has been speculated that the dead in bed syndrome may be mediated by hypoglycemia-induced fatal arrhythmias. In the current study, it is shown for the first time that fatal cardiac arrhythmias occur during severe hypoglycemia and can be reduced by ICV glucose infusion and prevented by β-adrenergic blockade, indicating that brain neuroglycopenia and the striking sympathoadrenal response mediate fatal cardiac arrhythmias during severe hypoglycemia (Fig. 7A).. In these experiments, diabetes per se nearly doubled the mortality risk associated with severe hypoglycemia. Uncontrolled diabetes is hypothesized to increase risk of fatal ...
Mortality owing to iatrogenic hypoglycemia represents a major concern for insulin-treated diabetic patients and their families. Determining the mechanisms by which hypoglycemia causes sudden death is critically important in order to find treatment strategies that could protect at-risk patients. Based on ECG anomalies reported during moderate hypoglycemia (26), it has been speculated that the dead in bed syndrome may be mediated by hypoglycemia-induced fatal arrhythmias. In the current study, it is shown for the first time that fatal cardiac arrhythmias occur during severe hypoglycemia and can be reduced by ICV glucose infusion and prevented by β-adrenergic blockade, indicating that brain neuroglycopenia and the striking sympathoadrenal response mediate fatal cardiac arrhythmias during severe hypoglycemia (Fig. 7A).. In these experiments, diabetes per se nearly doubled the mortality risk associated with severe hypoglycemia. Uncontrolled diabetes is hypothesized to increase risk of fatal ...
SADS UK - Preventing loss of life from Sudden Arrhythmic Death Syndrome (SADS) and highlighting cardiac risk in the young through to middle age.
Respiratory sinus arrhythmia is not considered a major health concern. However, other arrhythmias can sometimes indicate heart disease.. An older person with a severe arrhythmia may require a pacemaker. People with sleep apnea are also more likely to experience arrhythmias, including respiratory sinus arrhythmia.. Cases of respiratory sinus arrhythmia in children and young people will often improve without treatment, as someone ages. This is because a childs heart is still growing and developing and changes to the heart can lead to respiratory sinus arrhythmia.. If a child has a respiratory sinus arrhythmia, a doctor may wish to monitor it but will probably not offer any treatment unless the problem becomes severe, causes symptoms, or continues into adolescence.. However, cases in older people are more unusual and may require further examination. If respiratory sinus arrhythmia is caused by an underlying heart disease, then that will need to be treated separately.. ...
TY - JOUR. T1 - Coxsackie and adenovirus receptor is a modifier of cardiac conduction and arrhythmia vulnerability in the setting of myocardial ischemia. AU - Marsman, Roos F J. AU - Bezzina, Connie R.. AU - Freiberg, Fabian. AU - Verkerk, Arie O.. AU - Adriaens, Michiel E.. AU - Podliesna, Svitlana. AU - Chen, Chen. AU - Purfürst, Bettina. AU - Spallek, Bastian. AU - Koopmann, Tamara T.. AU - Baczko, Istvan. AU - Dos Remedios, Cristobal G.. AU - George, Alfred L.. AU - Bishopric, Nanette. AU - Lodder, Elisabeth M.. AU - De Bakker, Jacques M T. AU - Fischer, Robert. AU - Coronel, Ruben. AU - Wilde, Arthur A M. AU - Gotthardt, Michael. AU - Remme, Carol Ann. PY - 2014/2/18. Y1 - 2014/2/18. N2 - Objectives The aim of this study was to investigate the modulatory effect of the coxsackie and adenovirus receptor (CAR) on ventricular conduction and arrhythmia vulnerability in the setting of myocardial ischemia. Background A heritable component in the risk of ventricular fibrillation during myocardial ...
Its arrhythmia week on The Rounds Table! Should heart failure patients give up a caffeine jolt in the morning? How can we better identify appropriate patients for ICDs? Paxton Bach, fellow in General Internal Medicine at UBC, joins Kieran to discuss two exciting studies:. Studies that inform practice toward the best medical treatments are of utmost importance. But, arguably, studies that inform day to day lifestyle choice are those that provide real meaning to patients. For example, does a patient with a heart condition need to give up coffee? Kieran and Paxton discuss a study which examines whether, in patients with decreased ejection fraction, caffeine increases cardiac arrhythmias.. Next, Kieran takes listeners through the DANISH trial. The benefit of an implantable cardioverter-defibrillator (ICD) in patients with symptomatic systolic heart failure caused by ischemic heart disease has been well documented. However, before the DANISH trial, the evidence for implantation of an ICD for primary ...
Free, official info about 2015 ICD-9-CM diagnosis code 427.8. Includes coding notes, detailed descriptions, index cross-references and ICD-10-CM conversion info.
Anxiety and arrhythmia is not a one way street. Arrhythmia can also cause significant anxiety. Many things can lead to benign (not dangerous) arrhythmia, including exercise, dehydration, diet/caffeine, etc. Also, those that suffer from very minor stress or those that are thinking about their heart too often may be more prone to arrhythmia - even when theyre not suffering from anxiety at the time.. Unfortunately, those with anxiety are highly prone to suffering from extreme anxiety and panic attacks when an arrhythmia occurs as they worry about the health of their heart. After suffering from an arrhythmia, many with anxiety are also more prone to worrying about the arrhythmia again, thus causing further anxiety and greater risk of arrhythmia.. As you can see, it can create a very troubling cycle that can make it harder and hard to cope. Often arrhythmia is one of the primary reasons that an individuals anxiety starts to get out of hand.. ...
The use of conductive polymer composites (CPCs) as strain sensors has been widely investigated. A wide range of strain sensitivities and high repeatability are vital for different applications of CPCs. In this study, the relations of the conductive filler network and the strain-sensing behavior and electrical stability under fatigue cycles were studied systematically for the first time based on the conductive polymethylvinylsiloxane (PMVS) composites filled with both carbon nanotubes arrays (CNTAs) and carbon black (CB). It was proved that the composites could be fabricated with large strain-sensing capability and a wide range of strain sensitivities by controlling the volume ratio of CNTA/CB and their amounts. Additionally, the CNTA/CB/PMVS composite with 3 vol % content of fillers showed high sensitivity (GF is 10 at 60% strain), high repeatability (the relative standard deviation (RSD) of the max R/R0 value is 3.58%), and electrical stability under fatigue cycles (value range of R/R0 is 1.62 to 1.82)
Background: Air pollution has been associated with cardiac events, including sudden cardiac death. However, the temporal association for acute events is not clear. In this prospective study we follow patients with implantable cardioverter defibrillators (ICDs) to assess the acute effects of air pollution on ventricular arrhythmias.. Methods: Subjects were recruited from Tufts Medical Center Arrhythmia Clinic between September 2006 and March 2010. Inclusion criteria included prior implantation of a dual chamber ICD and residential zip codes within a 50-kilometer radius of the Harvard Supersite air quality monitoring station. Arrhythmias documented by the ICD were reviewed and interpreted by an electrophysiologist blinded to air quality. The correlations of sustained ventricular arrhythmias (defined as those necessitating treatment by the ICD) with air pollution, including PM2.5, black carbon (BC), sulfate, particle number, NO2, SO2, and O3 were assessed utilizing a case-crossover ...
There are a number of conditions that can contribute to cardiac arrhythmias in mesothelioma patients. Arrhythmias are rapid atypical heartbeats which lose the characteristic patterns observed in the normal electrocardiogram (EKG). In mesothelioma, primary cardiac tumors of the heart (pericardial mesothelioma) or in most cases the spread of mesothelioma to the cardiac silhouette, can be responsible for arrhythmias. The AV (atrial ventricular) node is composed of specialized tissues located between the atrium and ventricle. The purpose of the av node is to set cardiac rhythm. When malignancy impinges upon these tissues, arrhythmias can develop. Common presenting symptoms are similar to those of congestive heart failure: cardiac and pleural effusions, shortness of breath and extreme fatigue. Pulse will be irregular and in most cases rapid, greater than 100 beats per minute.. Surgery and the formation of scar tissue can damage this sensitive tissue following and EPP or PD. These complications are ...
Background: Cardiac arrhythmias are any abnormality or disruption of the normal activation sequence of the myocardium in the heart. Atrial fibrillation (AF) is the most common type of cardiac arrhythmia and is associated with increased mortality and morbidity. Patients with cardiac arrhythmias have a decreased quality of life (QoL) and an increased psychosocial burden. Yoga has demonstrated to be an effective tool in reducing blood pressure in patients with hypertension, reducing symptoms of depression, anxiety, and increasing QoL. Yoga as a treatment for patients with cardiac arrhythmias has yet to be investigated fully. Will yoga decrease the amount of cardiac arrhythmias in arrhythmia-prone individuals? Methods: An exhaustive search of available medical literature was performed using Medline-OVID, CINAHL, PubMed, and Web of Science using the keywords:
Cambridge Heart develops and commercializes non-invasive diagnostic tests for cardiac disease, with a focus on identifying those at risk for sudden cardiac arrest (SCA). The Company?s products incorporate proprietary Microvolt T-Wave Alternans measurement technologies including the patented Analytic Spectral Method? and ultrasensitive disposable electrode sensors. Medicare reimburses the Analytic Spectral Method? under its National Coverage Policy. Cambridge Heart, founded in 1990, is based in Tewksbury, MA. The company?s Microvolt T-Wave Alternans? (MTWA) test, developed by Cambridge Heart (OTCBB: CAMH), is based on research originally conducted at the Massachusetts Institute of Technology. http://www.cambridgeheart.com,http://www.cambridgeheart.com/, .. Statements contained in this press release are forward-looking statements for purposes of the safe harbor provisions under The Private Securities Litigation Reform Act of 1995. In some cases, we use words such as ?believes?, ?expects?, ...
BVT is an infrequent arrhythmia that has nevertheless mesmerized electrophysiologists for many years. It is most commonly observed under conditions of digitalis intoxication and in advanced heart disease.22 On ECG, BVT is manifested as an alternation in the polarity of the QRS axis in some of the leads; the remaining leads may demonstrate changes in morphology.22 The tachycardia is often regular, occurs in brief salvoes, and often resolves spontaneously or may degenerate into PVT or VF. The alternating pattern is usually associated with bundle branch block morphology in the precordial leads, with the alternating QRS complexes differing from each other in amplitude and duration. Since its first description in 1922,23 several hypotheses have been postulated for the mechanism of BVT, including enhanced automaticity with the existence of 2 separate ventricular foci22,24 or even reentry.22 More recently, the demonstration of RyR2 gain-of-function mutations in patients with familial CPVT has led to ...
HearTwave II Microvolt T-Wave Alternans System With Analytic Spectral Method,The HearTwave II system is the Cambridge Heart next generation Microvolt T-Wave Alternans (MTWA) testing platform which simplifies hospital and office-based sudden cardiac death risk stratification. This new system offers expanded versatility as it can be configured to perform MTWA and/or standard,medicine,medical supply,medical supplies,medical product
Heart arrhythmia, also known as cardiac dysrhythmia or irregular heartbeat, is a group of conditions in which the heartbeat is irregular, too fast, or too slow.[2] A heart rate that is too fast - above 100 beats per minute in adults - is called tachycardia and a heart rate that is too slow - below 60 beats per minute - is called bradycardia.[2] Many types of arrhythmia have no symptoms.[1] When symptoms are present these may include palpitations or feeling a pause between heartbeats.[1] More seriously there may be lightheadedness, passing out, shortness of breath, or chest pain.[1] While most types of arrhythmia are not serious, some predispose a person to complications such as stroke or heart failure.[2][3] Others may result in cardiac arrest.[3]. There are four main types of arrhythmia: extra beats, supraventricular tachycardias, ventricular arrhythmias, and bradyarrhythmias.[3] Extra beats include premature atrial contractions, premature ventricular contractions, and premature junctional ...
Electrocardiography and Dysrhythmia Monitoring Unit 4 chapter 32 Nursing Care of Clients with Cardiovascular Disorders SectionDiagnostic and Therapeutic Procedures Chapter 32 Electrocardiography and Dysrhythmia Monitoring Overview в-Џв-Џ Cardiac electrical activity can be monitored by using an ECG. The heart’s electrical activity can be monitored by a standard 12-lead ECG (resting ECG), ambulatory ECG (Holter monitoring), continuous cardiac monitoring, or by telemetry. View Media Supplement: в-Џв-Џ в-Џв-Џ ECG Strip (Image) Cardiac dysrhythmias are heartbeat disturbances (beat formation, beat conduction, or myocardial response to beat). Nurses should be familiar with cardioversion and defibrillation procedures for treating dysrhythmias. Electrocardiography в-Џв-Џ Electrocardiography uses an electrocardiograph to record the electrical activity of the heart over time. The electrocardiograph is connected by wires (leads) to skin electrodes placed on the chest and limbs of a ...
Health,...AUSTIN Texas May 11 /- The Texas Cardiac Arrhythmia Ins... ... In just one year the physician team at the Texas Cardiac Arrhythmia ... ...,Texas,Cardiac,Arrhythmia,Institute,at,St.,Davids,Medical,Center,Celebrates,Successful,First,Year,medicine,medical news today,latest medical news,medical newsletters,current medical news,latest medicine news
PMARP : Sudden cardiac death (SCD) is estimated to occur at an incidence of between 50 to 100 per 100,000 individuals in North America and Europe each year, claiming between 250,000 and 450,000 lives in the United States annually. In younger individuals (ages 15-35), the incidence of SCD is between 1 to 2 per 100,000 young individuals. The reported incidence of SCD is likely an underestimate since more overt causes of death, such as car accidents and drownings, may result from arrhythmogenic events. In cases of sudden unexplained death where autopsy does not detect a structural basis for sudden death, a hereditary arrhythmia may be suspected. Brugada syndrome (BrS) and long QT syndrome (LQTS) are inherited forms of cardiac arrhythmia that may cause sudden cardiac death. Postmortem diagnosis of a hereditary arrhythmia may assist in confirmation of the cause and manner of death, as well as risk assessment in living family members.   BrS is a genetic cardiac disorder characterized by ST segment
The 2016 Report on Holter Monitoring (Ambulatory Electrocardiography) Systems: World Market Segmentation by City The 2016 Report on Holter Monitoring (Ambulatory Electrocardiography) Systems: World Market - Market research report and industry analysis - 9137878
Andersen-Tawil syndrome (ATS) is a rare autosomal dominant channelopathy characterized by periodic paralysis, cardiac dysrhythmias, and distinct facial and skeletal characteristics, that may be variably present in the affected members. Mutations in the KCNJ2 and KCNJ5 gene have been associated with this disorder. We describe a family in which several members presented with different ATS phenotypes. The proband, a 4-year-old boy, presented with recurrent episodes of muscle weakness from an early age; two siblings suffered cardiac arrhythmia but had never experienced episodes of paralysis; their mother reported occasional muscle pain after exercise and unspecified cardiac arrhythmias ...
Texas Cardiac Arrhythmia Institute at St. Davids Medical Center opening new Electrophysiology Center - AUSTIN, Texas-The Texas Cardiac Arrhythmia Institute (TCAI)...
Long term continuous monitoring of electrocardiogram (ECG) in a free living environment provides valuable information for prevention on the heart attack and other high risk diseases. This paper presents the design of a real-time wearable ECG monitoring system with associated cardiac arrhythmia classification algorithms. One of the striking advantages is that ECG analog front-end and on-node digital processing are designed to remove most of the noise and bias. In addition, the wearable sensor node is able to monitor the patients ECG and motion signal in an unobstructive way. To realize the real-time medical analysis, the ECG is digitalized and transmitted to a smart phone via Bluetooth. On the smart phone, the ECG waveform is visualized and a novel layered hidden Markov model is seamlessly integrated to classify multiple cardiac arrhythmias in real time. Experimental results demonstrate that the clean and reliable ECG waveform can be captured in multiple stressed conditions and the real-time
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Suzanne Lowrys son, Max, died suddenly on the eve of his wedding. A year on, his mother shares her sense of loss - and her hope that others may be spared the same fate
Gene therapy has progressed from a dream to a bedside reality in quite a few human diseases. From its first application in adenosine deaminase deficiency, through the years, its application has evolved to vascular angiogenesis and cardiac arrhythmias. Gene based biological pacemakers using viral vectors or mesenchymal cells tested in animal models hold much promise. Induction of pacemaker activity within the left bundle branch can provide stable heart rates. Genetic modification of the AV node mimicking beta blockade can be therapeutic in the management of atrial fibrillation. G protein overexpression to modify the AV node also is experimental. Modification and expression of potassium channel genes altering the delayed rectifier potassium currents may permit better management of congenital long QT syndromes. Arrhythmias in a failing heart are due to abnormal calcium cycling. Potential targets for genetic modulation include the sarcoplasmic reticulum calcium pump, calsequestrin and sodium calcium ...
Gene therapy has progressed from a dream to a bedside reality in quite a few human diseases. From its first application in adenosine deaminase deficiency, through the years, its application has evolved to vascular angiogenesis and cardiac arrhythmias. Gene based biological pacemakers using viral vectors or mesenchymal cells tested in animal models hold much promise. Induction of pacemaker activity within the left bundle branch can provide stable heart rates. Genetic modification of the AV node mimicking beta blockade can be therapeutic in the management of atrial fibrillation. G protein overexpression to modify the AV node also is experimental. Modification and expression of potassium channel genes altering the delayed rectifier potassium currents may permit better management of congenital long QT syndromes. Arrhythmias in a failing heart are due to abnormal calcium cycling. Potential targets for genetic modulation include the sarcoplasmic reticulum calcium pump, calsequestrin and sodium calcium ...
A cardiac arrhythmia happens when your heart is beating (or contracting) in an irregular pattern. At one time or another, youve probably learned to place your fingers gently against your carotid artery in your neck to feel your pulse or heart beating. Usually, you can feel a steady pattern of beats as you count. But if you have an arrhythmia, the pulse or rhythm of your heart may be unpredictable or too fast or too slow.. There are many kinds of arrhythmias, but Id like to explain a very common and typically benign kind we often see patients for: premature heartbeats. Premature heartbeats are just that - a contraction that comes early and breaks the steady rhythm of the heart. It causes the succeeding heartbeat to be stronger, and its this beat (or beats) that people suddenly feel.. The sensation can be alarming. We get calls and see people for a variety of symptoms: they may feel just a single, occasional beat or a series of running beats. Usually, the beats come quickly and theyre gone, ...
Diagnosing heart arrhythmia In diagnosing an arrhythmia, a full physical will be performed with a complete blood analysis. The veterinarian will determine if an ECG or EKG are necessary. Blood work can establish whether a pet has anemia and can also detect whether the organs are working properly. An EKG can detect the arrhythmia, while an ECG can determine the type of arrhythmia. Chest X-rays might be necessary to determine if heart disease or heart failure has occurred. How is heart arrhythmia treated? After the veterinarian has obtained a positive diagnosis, they will discuss the various treatment options. Surgery and prescription medications are both available to your pet as possible therapies. Prescription medication - Several medications are available to help control arrhythmias, and the veterinarian will discuss which prescription is best for your pets age, gender, and breed. Surgery - There are two surgical options, both of which must be performed by a veterinary cardiology specialist. ...
RJ Patel, JM Walker, P Liu, B Xu, A Rodriguez, BW Spur, CE Hock. The Effect of Altering the Composition of Dietary Lipids on Arrhythmias and the Inflammatory Response Following Myocardial Ischemia/Reperfusion. J Am Osteopath Assoc 2004;104(1):10. doi: 10.7556/jaoa.2004.104.1.10.. Download citation file:. ...
After adjusting for several independent factors (demographics, cardiovascular risk factors, and comorbidities), patients with OSA had approximately twice the odds of having any cardiac arrhythmia (OR 1.91; CI 95% 1.27-3.11; p ,0.05).. DISCUSSION. Our study provides new information on the prevalence of arrhythmia in Arab patients with OSA. Moreover, OSA was an independent predictor of arrhythmias in our patients. In the literature, the reported incidence of arrhythmia in OSA patients ranges from 20% to 50%3. The explanation for this wide range includes the difference in arrhythmia definition, characteristics of the population or the sample studied (e.g., age), study design and sleep-disordered breathing (SDB) severity. The current study showed a prevalence of 26%, which is at the lower end of the range; however, the study group is relatively younger than studied samples in previous studies1,3,13,14. Our study revealed that patients with OSA had a significantly increased prevalence of PACs, PVCs, ...
After adjusting for several independent factors (demographics, cardiovascular risk factors, and comorbidities), patients with OSA had approximately twice the odds of having any cardiac arrhythmia (OR 1.91; CI 95% 1.27-3.11; p ,0.05).. DISCUSSION. Our study provides new information on the prevalence of arrhythmia in Arab patients with OSA. Moreover, OSA was an independent predictor of arrhythmias in our patients. In the literature, the reported incidence of arrhythmia in OSA patients ranges from 20% to 50%3. The explanation for this wide range includes the difference in arrhythmia definition, characteristics of the population or the sample studied (e.g., age), study design and sleep-disordered breathing (SDB) severity. The current study showed a prevalence of 26%, which is at the lower end of the range; however, the study group is relatively younger than studied samples in previous studies1,3,13,14. Our study revealed that patients with OSA had a significantly increased prevalence of PACs, PVCs, ...
An automated external defibrillator (AED) is a portable electronic device that automatically diagnoses the life-threatening cardiac arrhythmias of ventricular fibrillation and ventricular tachycardia in a patient, and is able to treat them through defibrillation, the application of electrical therapy which stops the arrhythmia, allowing the heart to re-establish an effective rhythm.
Cardiac arrhythmias are a debilitating, potentially life threatening condition involving aberrant electrical activity in the heart which results in abnormal heart rhythm. Virtual cardioscopy can play an important role in minimally invasive treatment of cardiac arrhythmias. Second and third generation image-guidance systems are now available for the treatment of arrhythmias using RF ablation catheters. While these 3D tools provide useful information to the clinician, additional enhancements to the virtual cardioscopy display paradigm are critical for optimal therapy guidance. Based on input from clinical collaborators, several key visualization techniques have been developed to enhance the use of virtual cardioscopy during cardiac ablation procedures. We have identified, designed and incorporated several visual cues important to successful virtual cardioscopy. These features include the use of global reference maps, parametric mapping, and focused navigation and targeting using abnormal ...
A system, method, or device classifies an arrhythmia according to the temporal order in which a depolarization wave associated with a particular heart contraction is received at a plurality of electrodes. One or more antiarrhythmia therapies is mapped to each arrhythmia classification. When a particularly classified arrhythmia is detected, the correspondingly mapped therapy list is selected and an appropriate antiarrhythmia therapy delivered. In one example, the particular therapy delivered in response to an arrhythmia depends at least in part on its historical success in treating arrhythmias of that classification.
BACKGROUND: Short QT syndrome (SQTS) carries an increased risk for sudden cardiac death. However, only a short QT interval does not express the risk of ventricular arrhythmias. Thus, additional evaluation of the repolarization abnormality in SQTS pat
Therapies for ventricular arrhythmias have focused predominately on disruption of reentrant circuits. Investigators have demonstrated reductions in ventricular arrhythmia susceptibility using transgenes that increase either myocyte refractory properties or myocardial tissue conduction velocity. In a porcine model of healed myocardial infarction and inducible VT, gene transfer of KCNH2-G628S shut down the repolarizing IKr current, prolonging the myocyte refractory period and eliminating all ventricular arrhythmia inducibility.10 In the same model, connexin 43 (Cx43) gene transfer in the infarct scar border improved conduction and reduced arrhythmia susceptibility.7 Both these studies used a coronary perfusion delivery strategy.. An alternative approach to normalizing slow myocardial conduction was explored by Lau et al11 They noted that the endogenous cardiac sodium channel (SNC5a) was less active at the depolarized membrane potentials typical of damaged myocytes postinfarction. SCN4A, the ...
Learn more about Risk Factors for Arrhythmias (Heart Rhythm Disturbances) at Medical City Dallas Main Page Types of Arrhythmias ...
Learn more about Type of Arrhythmias (Heart Rhythm Disturbances) at West Florida Hospital Main Page Types of Arrhythmias Cause ...
Learn more about Diagnosis of Arrhythmias (Heart Rhythm Disturbances) at Medical City Dallas Main Page Types of Arrhythmias ...
Arrhythmias can range from incidental, asymptomatic clinical findings to life-threatening abnormalities. In some human arrhythmias, precise mechanisms are known, and treatment can be targeted specifically against those mechanisms. In other cases, mechanisms can be only inferred, and the choice of drugs is based largely on the results of prior experience. Anti-arrhythmic drug therapy can have 2 goals: termination of an ongoing arrhythmia or prevention of an arrhythmia. Unfortunately, anti-arrhythmic drugs not only help to control arrhythmias but also can cause them, especially during long-term therapy. Thus, prescribing anti-arrhythmic drugs requires that precipitating factors be excluded or minimized, that a precise diagnosis of the type of arrhythmia be made, and that the risks of drug therapy can be minimized. ...
Management of Cardiac Arrhythmias. Contemporary cardiology. 34. Hanumana Press. pp. 123-140. doi:10.1007/978-1-60761-161-5. ... A cardiac electrophysiology study (EP test or EP study) is a minimally invasive procedure using catheters introduced through a ... Handbook of cardiac electrophysiology : a practical guide to invasive EP studies and catheter ablation. Murgatroyd, Francis D. ... Then the electrophysiologist tries to provoke arrhythmias and reproduce any conditions that have resulted in the patient's ...
The arrhythmias that those with CPVT experience are caused by abnormalities in the way that cardiac muscle cells control their ... Landstrom AP, Dobrev D, Wehrens XH (June 2017). "Calcium Signaling and Cardiac Arrhythmias". Circulation Research. 120 (12): ... Semsarian C, Ingles J (October 2016). "Molecular autopsy in victims of inherited arrhythmias". Journal of Arrhythmia. 32 (5): ... ventricular arrhythmias or cardiac arrest despite taking appropriate medication. These devices can be life-saving, although the ...
... works as an anti-arrhythmic agent and is used to treat cardiac arrhythmia. It induces rapid block of the ... Procainamide is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is classified by the ... 1983). Drug Treatment of Cardiac Arrhythmias. Mount Kisco: Futura Publishing Company. pp. 73-74. ISBN 0879931906. Stiell, Ian G ... Procainamide is used for treating ventricular arrhythmias: ventricular ectopy and tachycardia and supraventricular arrhythmias ...
Katzung, B: Basic and Clinical Pharmacology (10th ed.), chapter 14: "Agents Used in Cardiac Arrhythmias", The McGraw-Hill ... Afterdepolarizations may lead to cardiac arrhythmias. Early afterdepolarizations (EADs) occur with abnormal depolarization ... Early afterdepolarizations can result in torsades de pointes, tachycardia, and other arrhythmias. EADs can be potentiated by ... Cranefield, PF: The Conduction of the Cardiac Impulse. New York, Future Publishing Co. 1975 Nelson Spruston, "Pyramidal Neurons ...
The term ventricular arrhythmia refers to the group of abnormal cardiac rhythms originating from the ventricle, which includes ... In those with cardiac arrest due to ventricular tachycardia, survival is about 45%. An implantable cardiac defibrillator or ... "Ventricular arrhythmias and sudden cardiac death". Lancet. 380 (9852): 1520-9. doi:10.1016/S0140-6736(12)61413-5. PMID 23101719 ... Pulseless VT is associated with no effective cardiac output, hence, no effective pulse, and is a cause of cardiac arrest. In ...
This may cause arrhythmias and cardiac arrest. The use of a bolus injection of potassium chloride in executions by lethal ... In some cells, the membrane potential is always changing (such as cardiac pacemaker cells). For such cells there is never any " ... which depolarizes and contracts the cardiac cells permanently, not allowing the heart to repolarize and thus enter diastole to ...
... (March 1949). "The Diagnosis and Management of Cardiac Arrhythmias". Journal of the National Medical ... "The Diagnosis and Management of Cardiac Arrhythmias", Journal of the National Medical Association (March 1949) "The Value of ... 5 (1). Costumed interpreters greeted visitors and provided insight into cardiac medicine and the city's race relations in the ...
... due to such arrhythmias require implantation of an internal defibrillator and/or cardiac pacemaker to stop such arrhythmias and ... Individuals who develop cardiac chest pain are generally treated empirically as an "acute coronary syndrome", and are ... Kundu A, Vaze A, Sardar P, Nagy A, Aronow WS, Botkin NF (March 2018). "Variant Angina and Aborted Sudden Cardiac Death". ... Seven major factors (i.e. history of out of hospital cardiac arrest [score = 4]; smoking, angina at rest, physically ...
Rosenbaum, David S.; Jalife, José (2001). Optical mapping of cardiac excitation and arrhythmias. Wiley-Blackwell. p. 251. ISBN ...
ISBN 978-0-7817-2486-9. Sung, Ruey J.; Michael R. Lauer (2000). Fundamental Approaches to the Management of Cardiac Arrhythmias ... Podrid, Philip J.; Peter R. Kowey (2001). Cardiac Arrhythmia: Mechanisms, Diagnosis, and Management. Lippincott Williams & ... Cardiogenic shock is defined as a hemodynamic state in which the heart cannot produce enough of a cardiac output to supply an ... Yip HK, Wu CJ, Chang HW, Wang CP, Cheng CI, Chua S, Chen MC (2003). "Cardiac rupture complicating acute myocardial infarction ...
"Musical structures and cardiac arrhythmia". IRCAM Research News. 2019-11-27. Retrieved 2019-08-12. "London International Piano ... The music of arrhythmia - Queen Mary University of London". www.qmul.ac.uk. Retrieved 2019-10-01. "A pianist is composing ... and in the analysis of electrocardiographic traces of arrhythmia. She is currently a senior researcher at the Science et ...
"Arrhythmias and the 'Holiday Heart': Alcoholassociated cardiac rhythm disorders". American Heart Journal. 95 (5): 555-562. doi: ... Some abnormal heart rhythms (arrhythmias) associated with Holiday heart syndrome after binge drinking can lead to sudden death ... Atrial fibrillation is the most common arrhythmia in holiday heart syndrome. Symptoms usually resolve themselves within 24 ...
White had succumbed to cardiac arrhythmia. According to the Mecklenburg County Medical Examiner's Office, the most likely cause ... was the cardiac and pulmonary sarcoidosis White had lived with for years. It was also stated that sleep apnea, from which White ...
2009). "Базовые механизмы аритмий сердца" [Basic mechanisms of cardiac arrhythmias]. In Ardashev, prof. A.V. (ed.). Клиническая ... see References Now the sad role of re-entry as the causes of various cardiac arrhythmias is well recognized. The basic scheme ... bifurcation memory in a model of cardiac tissue). A huge role in the study of autowave models of cardiac tissue belongs to ... Efimov, I. R.; Krinsky, V. I.; Jalife, J. (1995). "Dynamics of rotating vortices in the Beeler-Reuter model of cardiac tissue ...
"Types of Arrhythmia". nhlbi.nih.gov. July 1, 2011. Archived from the original on June 7, 2015. Retrieved March 7, 2015. Puyo L ... a feeling of cardiac "pause". Taking (prolonged) pulse may result in a rhythm that seems irregular. Electrocardiography and ... They are the most common arrhythmia. The normal heart contraction comes from a cyclic membrane depolarization (reversal of the ...
Bennett, David H. (2006-09-29). Cardiac Arrhythmias 7th Edition: Practical Notes on Interpretation and Treatment. CRC Press. ... Steurer, G.; Frey, B.; Gürsoy, S.; Tsakonas, K.; Celiker, A.; Andries, E.; Kuck, K.; Brugada, P. (1994-11-01). "Cardiac ... Accessory pathways are abnormal conduction pathways formed during cardiac development. An example of pre-excitation syndromes ...
The main causes of death are ventricular arrhythmias and asystole, paralysis of the heart or of the respiratory center. The ... All patients require close monitoring of blood pressure and cardiac rhythm. Gastrointestinal decontamination with activated ... Other drugs used for ventricular arrhythmia include lidocaine, amiodarone, bretylium, flecainide, procainamide, and mexiletine ... Cardiovascular features include hypotension, sinus bradycardia, and ventricular arrhythmias. Other features may include ...
Cardiac involvement is recurrent in Fabry patients. Patients have developed hypertrophic cardiomyopathy, arrhythmias, ... The cardiac complications of Fabry disease include abnormal heart rhythms, which may require a pacemaker or implantable ... These abnormal heart rhythms can cause blackouts, palpitations, or even sudden cardiac death. Sphingolipids can also build up ... In severe cases there is renal, cerebrovascular, and cardiac involvement and it is predominately responsible for premature ...
CS1 maint: discouraged parameter (link) Atkins, Ben (9 June 2011). "Cardiac Arrhythmia forces Mario Aerts to retire early". ...
Noble, D (2002). "Unraveling the genetics and mechanisms of cardiac arrhythmia". Proceedings of the National Academy of ... With J.J.B.Jack & R.W.Tsien[ISBN missing] Electrophysiology of Single Cardiac Cells, Academic Press 1987, with T Powell[ISBN ... Noble, Denis (1960). "Cardiac action and pacemaker potentials based on the Hodgkin-Huxley equations". Nature. 188 (4749): 495-7 ... Noble, D; Tsien, R. W. (1968). "The kinetics and rectifier properties of the slow potassium current in cardiac Purkinje fibres ...
The device is therefore capable of correcting most life-threatening cardiac arrhythmias. The ICD is the first-line treatment ... Cardiac Psychology Lab, Focus on ICD Samuel F. Sears, Jr., Ph.D., East Carolina University, Cardiac Psychology, ICD QoL ... for the Sudden Cardiac Death in Heart Failure Trial (SCD-HeFT) Investigators. Amiodarone or an implantable cardioverter- ... Similarly, ICD use in primary prevention is to prevent cardiac death in patients who are at risk for sustained ventricular ...
The effects on the dog are quite predictable: cardiac failure leading to death. Treatment of an infected dog is difficult, ... Dobermanns, in addition to heart muscle failure, are prone to ventricular arrhythmias. Boxer dogs are predisposed to a unique ... Affected dogs are at risk of syncope and sudden cardiac death. Myocardial failure and congestive heart failure are rare ... March 2004). "Arrhythmogenic right ventricular cardiomyopathy causing sudden cardiac death in boxer dogs: a new animal model of ...
doi:10.1111/j.1532-7795.2011.00762.x. Grossman P, Wilhelm FH, Spoerle M (August 2004). "Respiratory sinus arrhythmia, cardiac ... Grossman, Paul; Taylor, Edwin W. (2007). "Toward understanding respiratory sinus arrhythmia: relations to cardiac vagal tone, ... Respiratory sinus arrhythmia (RSA) is typically a benign, normal variation in heart rate that occurs during each breathing ... It has been suggested that RSA may have evolved to save energy for both cardiac and respiratory systems by reducing the heart ...
Pilot studies have shown efficacy in various cardiac arrhythmia. Whether these effects are from the influence of gluconic acid ...
Avella J, Wilson JC, Lehrer M (March 2006). "Fatal cardiac arrhythmia after repeated exposure to 1,1-difluoroethane (DFE)". The ... Difluoroethane is an intoxicant and precipitates fatal cardiac arrhythmia. Several reports of fatal car crashes have been ...
doi:10.1111/j.1532-7795.2011.00762.x. Grossman P, Wilhelm FH, Spoerle M (August 2004). "Respiratory sinus arrhythmia, cardiac ... These cardiac nerves go on to form cardiac and pulmonary plexuses around the heart and lungs. As the main vagus nerves continue ... by which the parasympathetic nervous system acts on vascular and cardiac control is the so-called respiratory sinus arrhythmia ... Another nerve that comes off the vagus nerves approximately at the level of entering the thorax are the cardiac nerves. ...
This medical condition (cardiac arrhythmia) can't be easily diagnosed. Lang "procures" Wheeler's medical record for the Nazis ...
Additionally, it may lead to seizures, arrhythmias, and may progress to cardiac arrest. This reaction may stem from an allergy ...
Mirkovic S, Seymour AM, Fenning A, Strachan A, Margolin SB, Taylor SM, Brown L (February 2002). "Attenuation of cardiac ... "Pirfenidone mitigates left ventricular fibrosis and dysfunction after myocardial infarction and reduces arrhythmias". Heart ... The antifibrotic effect of pirfenidone has been further established in animal models of cardiac (heart), renal (kidney), and ...
He died of cardiac arrhythmia, said his daughter, Penelope Green. Mr. Green, a retired officer of the United States Information ... died on September 5, 1990 of cardiac arrhythmia. A Change in the Weather American Propaganda Abroad George Bush: An Intimate ...
Long-term suppression of TSH values below normal values will frequently cause cardiac side-effects and contribute to decreases ... starting at higher doses may cause acute coronary syndrome or an arrhythmia.[11] ... but was withdrawn due to cardiac side effects. ...
Different forms of cardiac arrhythmia shown in an Electrocardiogram. This short article about biology can be made longer. You ... Arrhythmia (commonly called irregular heartbeat) is the name for a number of conditions, where the heartbeat is not normal. It ... Arrhythmia. group of conditions in which the heartbeat is irregular, too fast, or too slow ... Retrieved from "https://simple.wikipedia.org/w/index.php?title=Arrhythmia&oldid=6797586" ...
... or cardiac arrhythmias Nuchal rigidity Subhyaloid retinal hemorrhages Altered level of consciousness Anisocoria, Nystagmus ...
Biventricular pacing alone is referred to as CRT-P (for pacing). For selected patients at risk of arrhythmias, CRT can be ... Main article: Cardiac resynchronization therapy. Cardiac resynchronization therapy (CRT) is used for people with heart failure ... Lidwell M C, "Cardiac Disease in Relation to Anaesthesia" in Transactions of the Third Session, Australasian Medical Congress, ... For the natural pacemaker in the heart, see Cardiac pacemaker.. A pacemaker (or artificial pacemaker, so as not to be confused ...
Bennett, David H. (2012). Bennett's Cardiac Arrhythmias: Practical Notes on Interpretation and Treatment (in ଇଂରାଜୀ). John ... "How Are Arrhythmias Diagnosed?". NHLBI. July 1, 2011.. *↑ "How Are Arrhythmias Treated?". NHLBI. July 1, 2011. Retrieved 27 ... "What Are the Signs and Symptoms of an Arrhythmia?". NHLBI. July 1, 2011. Retrieved 27 September 2016.. ... ventricular arrhythmia) ଯୋଗୁ ହୁଏ ଯାହା ନିଳୟରୁ (en:ventricle) ଆରମ୍ଭ ହୁଏ ।[୧] ଇସିଜି (en:electrocardiogram), ହୋଲ୍ଟର ମୋନିଟର (holter ...
Taylor CW, Nisbet A, McGale P, Darby SC (December 2007). "Cardiac exposures in breast cancer radiotherapy: 1950s-1990s". ... heart arrhythmia and peripheral artery disease. Radiation-induced fibrosis, vascular cell damage and oxidative stress can lead ...
Atrial fibrillation is one of the most common cardiac arrhythmias. In general, it is an irregular, narrow complex rhythm. ... Ventricular tachycardia (VT or V-tach) is a potentially life-threatening cardiac arrhythmia that originates in the ventricles. ... from healthy response to exercise or from cardiac arrhythmia), and that tachyarrhythmia be reserved for the pathologic form ( ... Unstable means that either important organ functions are affected or cardiac arrest is about to occur. In those that are ...
Atrial fibrillation is one of the most common cardiac arrhythmias. In general, it is an irregular, narrow complex rhythm. ... Ventricular tachycardia (VT or V-tach) is a potentially life-threatening cardiac arrhythmia that originates in the ventricles. ... from healthy response to exercise or from cardiac arrhythmia), and that tachyarrhythmia be reserved for the pathologic form ( ... that is, an arrhythmia of the rapid rate type). This is why five of the previously referenced dictionaries do not enter cross- ...
Clinical cardiac electrophysiology (also referred to as cardiac electrophysiology, arrhythmia services, or electrophysiology), ... Southwestern Cardiac Arrhythmia Clinical Electrophysiology Institute. *Cleveland Clinic Cardiac Electrophysiology and Pacing ... arrhythmias). They are trained to perform interventional and surgical procedures to treat cardiac arrhythmia. ... in the case of intra-cardiac EPS, to electrically stimulate it in the attempt to induce arrhythmias for diagnostic purposes (" ...
Leelakanok N, Holcombe A, Schweizer ML (2015). "Domperidone and Risk of Ventricular Arrhythmia and Cardiac Death: A Systematic ... Cardiac reactions[edit]. Domperidone use is associated with an increased risk of sudden cardiac death (by 70%)[38] most likely ... "Risk of serious ventricular arrhythmia and sudden cardiac death in a cohort of users of domperidone: a nested case-control ... "Domperidone and ventricular arrhythmia or sudden cardiac death: a population-based case-control study in the Netherlands". Drug ...
SADS, or sudden arrhythmia death syndrome, is a term used to describe sudden death due to cardiac arrest brought on by an ... Not all the electrical impulses of the heart produce audible or palpable beats; in many cardiac arrhythmias, the premature or ... Automaticity refers to a cardiac muscle cell firing off an impulse on its own. Every cardiac cell has this potential: if it ... Every cardiac cell is able to transmit impulses in every direction, but will only do so once within a short period of time. ...
... long QT syndrome and other serious cardiac arrhythmias including torsades de pointes, blackwater fever, disseminated ... Blood glucose, electrolyte and cardiac monitoring are not necessary when quinine is given by mouth. ... quinine can cause heart arrhythmias, and should be avoided.[citation needed] ...
Cardiac arrhythmia (where the heart beats in a way that is not normal) ... Cardiac arrest[change , change source]. Epinephrine can re-start a person's heart when they are in cardiac arrest (their heart ... Soar, Perkins, et al (2010) European Resuscitation Council Guidelines for Resuscitation 2010 Section 8. Cardiac arrest in ... "Adrenaline for out-of-hospital cardiac arrest resuscitation: a systematic review and meta-analysis of randomized controlled ...
රුධිර සංසරණය හා සබැඳි රෝගයක් පිළිබඳ මෙම ලිපිය තවමත් අංකුර ලිපියකි. විකිපීඩියාවට උදවුවක් ලෙසින් ඔබ හට එය විහිදුවාලිය හැක. ...
van Loon, G (April 2019). "Cardiac Arrhythmias in Horses". The Veterinary Clinics of North America. Equine Practice. 35 (1): 85 ... American Heart Association Electrocardiography and Arrhythmias Committee and Exercise Cardiac Rehabilitation, and Secondary ... "Journal of Arrhythmia (Review). 33 (4): 345-67. doi:10.1016/j.joa.2017.05.004. PMC 5529598. PMID 28765771.. ... "Circulation: Arrhythmia and Electrophysiology. 8 (2): 296-302. doi:10.1161/CIRCEP.114.001909. PMC 4731871. PMID 25684755.. ...
... potentially lethal cardiac arrhythmias, airway or respiratory compromise (such as ventilator support), acute renal failure, or ... ICU delirium, formerly and inaccurately referred to as ICU psychosis, is a syndrome common in intensive care and cardiac units ...
... they are called arrhythmia, hypertension, and hyperthermia, and may lead to rhabdomyolysis, stroke, cardiac arrest, or seizures ...
Halperin, Daniel (2008). Pacemakers and Implantable Cardiac Defibrillators: Software Radio Attacks and Zero-Power Defenses (PDF ... Circ Arrhythmia Electrophysiol. 2: 29-34. doi:10.1161/CIRCEP.108.795906.. CS1 maint: Explicit use of et al. (link) CS1 maint: ... The electrodes are placed in contact with the outer wall of the ventricle (epicardium) to maintain satisfactory cardiac output ... Cleland J, Daubert J, Erdmann E, Freemantle N, Gras D, Kappenberger L, Tavazzi L (2005). "The effect of cardiac ...
... because overdosing has the potential to cause fatal cardiac arrhythmias.[10]. In the context of psychotic depression, the ...
Behere, SP; Weindling, SN (2014). "Inherited arrhythmias: The cardiac channelopathies.". Annals of pediatric cardiology 8 (3): ...
He named this herbal drug "Zarnab" and used it as a cardiac remedy. This was the first known use of a calcium channel blocker ... hypertension, arrhythmia, cluster headache[1]. ATC code. C08. External links. MeSH. D002121. ... By having both cardiac depressant and vasodilator actions, benzothiazepines are able to reduce arterial pressure without ... By acting on cardiac muscles (myocardium), they reduce the force of contraction of the heart. ...
This causes kidney damage and the high levels of potassium can cause cardiac arrhythmia. Although prophylaxis is available and ...
"Guideline 11.5: Medications in Adult Cardiac Arrest" (PDF). Australian Resuscitation Council. December 2010. Archived from the ... Adverse reactions to adrenaline include palpitations, tachycardia, arrhythmia, anxiety, panic attack, headache, tremor, ... Epinephrine is used to treat a number of conditions including: cardiac arrest, anaphylaxis, and superficial bleeding.[14] It ... While epinephrine is often used to treat cardiac arrest, it has not been shown to improve long-term survival or mental function ...
However, these agents may precipitate prolongation of the QT interval and consequently provoke a ventricular arrhythmia such as ... higher cardiac output, and disorders in blood-clotting that may lead to organ failure.[18] Fever is the most common presenting ... Dobutamine can also be used in hypotensive septic shock to increase cardiac output and correct blood flow to the tissues.[67] ... reducing cardiac contractility and causing heart failure. In the gastrointestinal tract, increased permeability of the mucosa ...
cardiac arrhythmias. coma and possible death. [14] Toxicology[edit]. Domoic acid producing algal blooms are associated with the ...
Merck argued that the death was due to cardiac arrhythmia, which had not been shown to be associated with rofecoxib use. The ... Any increased risk of renal and arrhythmia pathologies associated with the class of COX-2 inhibitors, e.g. celecoxib (Celebrex ... Zhang J, Ding EL, Song Y (October 2006). "Adverse effects of cyclooxygenase 2 inhibitors on renal and arrhythmia events: meta- ... "Complications of the COX-2 inhibitors parecoxib and valdecoxib after cardiac surgery". The New England Journal of Medicine. 352 ...
Arrhythmia, orthostatic hypotension, seizure, hypoglycemia[1]. Treatment. Avoiding triggers, drinking sufficient fluids, ... Occasionally a cardiac pacemaker may be used.[2] Reflex syncope affects at least 1 per 1,000 people a year.[1] It is the most ... leading to a decrease in cardiac output that is significant enough to result in a loss of consciousness. It is thought that ...
... as the combination of alcohol and hyperthermia increases the likelihood of dangerous cardiac arrhythmias.[47] ... Additional associated phenomena are dehydration, metabolic acidosis, disturbed prostaglandin synthesis, increased cardiac ... increased cardiac output, vasodilation, sleep deprivation and malnutrition. Beverage-specific effects of additives or by- ...
Cardiovascular: tachycardia, cardiac arrhythmias, angina pectoris, vasoconstriction with hypertension. *Dermatological: ... Schier JG, Traub SJ, Hoffman RS, Nelson LS (2003). "Ephedrine-induced cardiac ischemia: exposure confirmed with a serum level ...
... especially its tendency to cause fatal cardiac arrhythmia analogous to what is now termed "sudden sniffer's death". Some people ... anesthetic use of chloroform has been discontinued because it caused deaths due to respiratory failure and cardiac arrhythmias ... It was only in 1911 that Levy proved in experiments with animals that chloroform can cause cardiac fibrillation. The ...
Treatments and Tools for cardiac arrhythmia. Find cardiac arrhythmia information, treatments for cardiac arrhythmia and cardiac ... MedHelps cardiac arrhythmia Center for Information, Symptoms, Resources, ... My mom died at age 53 and my sister died at age 38 of a cardiac arrhythmia. What are my ch... ... Sould I be worried about Cardiac Arrhythmia (or any other heart diease) if im 16 - Heart Disease Community ...
Enalapril prevents cardiac fibrosis and arrhythmias in hypertensive rats.. M Pahor, R Bernabei, A Sgadari, G Gambassi, P Lo ... Enalapril prevents cardiac fibrosis and arrhythmias in hypertensive rats.. M Pahor, R Bernabei, A Sgadari, G Gambassi, P Lo ... Enalapril prevents cardiac fibrosis and arrhythmias in hypertensive rats.. M Pahor, R Bernabei, A Sgadari, G Gambassi, P Lo ... To evaluate the effects of hypertension on cardiac hypertrophy, on myocardial structure, and on ventricular arrhythmias, 27 3- ...
An implantable programmable drug delivery system for injection of a pharmaceutical agent into the peritoneum to treat cardiac ... arrhythmia is described. The device consists of essentially three components: a main body containing electronics, power supply ... Cardiac Pacemakers, Inc.. Drug delivery system for implantable cardiac device. US7209783. Apr 16, 2002. Apr 24, 2007. Cardiac ... Cardiac Pacemakers, Inc.. Implantable device for delivering cardiac drug therapy. US7089055. Jun 28, 2002. Aug 8, 2006. Cardiac ...
Characteristic Cardiac Scar Pattern Predicts Risk Of Fatal Arrhythmias. Nov 2, 2005 - 3:51:00 AM ... offer promise that cardiac MRI might prove useful in screening people at moderate risk of sudden cardiac death from arrhythmias ... a cardiac electrophysiology, clinical and research fellow at Hopkins. Cardiac MRI is already useful for assessing the structure ... In this test, a thin catheter is inserted into the heart to try to induce an arrhythmia, something that will fail if the heart ...
The Cardiac Arrhythmia Service is a group of health professionals dedicated to the diagnosis, assessment, management and ... Cardiac Arrhythmia Service. Patient resources Clinics, programs & services > Cardiac Arrhythmia Service , Patient resources ...
... or cardiac rhythm disturbances, are usually diagnosed based on the persons symptoms, medical history, risk factors, a physical ... Continue Learning about Arrhythmia. Arrhythmia A type of heart disease, arrhythmia causes our hearts to beat too fast, too slow ... A cardiac arrhythmia such as atrial fibrillation can be diagnosed in different ways. In addition to reviewing your medical ... Doctors diagnose cardiac arrhythmia with monitors, says James Mock, MD, a cardiologist at MountainView Hospital. In this video ...
... Joint collaboration between the European Heart Academy of ESC, ... The Diploma of Advanced Studies in Cardiac Arrhythmia Management trains future leaders in arrhythmology to deliver state-of-the ... Module 2: Fundamentals of Cardiac Arrhythmogenesis 1-5 April 2017 , Maastricht. Module 3: How to organise an arrhythmia unit?. ... Module 1: Towards an optimal use of the ECG in cardiac arrhythmia management. 4-8 February 2017 , Maastricht ...
Learn more about Cardiac Arrhythmia at Blake Medical Center Uses None Other Proposed Natural Treatments Acupuncture ... ... Proposed Natural Treatments for Cardiac Arrhythmia. Herbs and Supplements. Although the use of fish oil to help prevent ... Conventional treatment for arrhythmia depends on the type involved. Sinus arrhythmias are often left untreated. More serious ... and the net result can be cardiac arrhythmias 5-8 One small double-blind, placebo-controlled study found that magnesium ...
Wrist and arm sensing technologies for cardiac arrhythmias detection in long term monitoringSummaryAbnormal heart rhythms are a ... Periodic Reporting for period 1 - WASTCArD (Wrist and arm sensing technologies for cardiac arrhythmias detection). Reporting ... Title: Wrist and arm sensing technologies for cardiac arrhythmias detection in long term monitoring. Summary. Abnormal heart ... Sudden cardiac death accounts for 50% of cardiac mortality in developed countries; ventricular tachycardia or ventricular ...
Proceedings of the 8th International Workshop on Cardiac Arrhythmias by Antonio Raviele. Buy a discounted Hardcover of Cardiac ... Cardiac Arrhythmias 2003. Proceedings of the 8th International Workshop on Cardiac Arrhythmias. By: Antonio Raviele (Editor). ... Ventricular Arrhythmias and Sudden Death. Coffee Enhances Sympathetic Activity and Induces Cardiac Arrhythmias: True or False? ... The field of cardiac arrhythmias has been evolving so fast during the last years that scientific meetings are frequently ...
Overview of arrhythmias. Abnormal cardiac rhythms are called cardiac arrhythmias. Cardiac arrhythmias are associated with ... abnormal propagation of a wave of cardiac excitation, or some combination of the two. Cardiac arrhythmias can manifest ... "Cardiac arrhythmia" by Flavio H Fenton, Elizabeth M. Cherry and Leon Glass is licensed under a Creative Commons Attribution- ... Cardiac arrhythmia is the condition in which the hearts normal rhythm is disrupted. In this article, we describe the hearts ...
Cardiac arrhythmias comprise a heterogenous group of disorders ranging from benign premature heart beats to malignant sustained ... Cardiac arrhythmias comprise a heterogenous group of disorders ranging from benign premature heart beats to malignant sustained ... Ehdaie A., Chugh S.S. (2018) Sex Differences in Cardiac Arrhythmias. In: Mehta J., McSweeney J. (eds) Gender Differences in the ... This chapter will review sex differences in different cardiac arrhythmias with an emphasis on clinical evaluation, treatment, ...
Catheter ablation for cardiac arrhythmias. BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7286.613/a (Published 10 March ...
... * 1. This Article Has Been Brought to You for Free by WHAT IS www.freud-sigmund.com CARDIAC ... CARDIAC ARRHYTHMIAS TREATMENT IN TA... by integratedcardiac... 574 views * State of art mapping and imaging te... by Taiwan ... Anextra systole interrupts normal Atria arrhythmias originate in the atria:sequence of activation of cardiac - Ectopic atria - ... Ventricle can sinceoccur frequently we speak of arrhythmia. Arrhythmias compensate for this loss but long term exhaustion ...
The first edition of Management of Cardiac Arrhythmias, published over ten years ... Few areas of medicine have evolved as rapidly as cardiac electrophysiology. What were only a short time ago seen to be lethal ... "This is a fine book on cardiac arrhythmias and provides a bridge from clinical cardiology and arrhythmia management to ... Management of Cardiac Arrhythmias. Editors: Yan, Gan-Xin, Kowey, Peter R. (Eds.) ...
Treatment of cardiac arrhythmias with phenytoin Br Med J 1969; 4 :270 ... Phenytoin was given intravenously in 37 patients with cardiac arrhythmias-21 had acute myocardial infarction and 16 had other ... Treatment of cardiac arrhythmias with phenytoin. Br Med J 1969; 4 doi: https://doi.org/10.1136/bmj.4.5678.270 (Published 01 ... Digitalis played no part in producing any of the arrhythmias. Phenytoin was used orally for suppressing and preventing abnormal ...
Clinical Aspects of Cardiac Arrhythmias. Recent years have seen the publication of many textbooks on cardiac arrhythmias, some ... Clinical Aspects of Cardiac Arrhythmias. Recent years have seen the publication of many textbooks on cardiac arrhythmias, some ... metabolic aspects of cardiac arrhythmias and reperfusion arrhythmias, which are not directly or exclusively clinical. However, ... Although the epidemiology of clinical arrhythmias is difficult to dis- cover, it is widely appreciated that arrhythmias are ...
Cardiac arrhythmia surgery was initiated in 1968 with the first successful division of an accessory AV connection for the Wolff ... Cardiac surgery for arrhythmias Pacing Clin Electrophysiol. 2004 Feb;27(2):266-82. doi: 10.1111/j.1540-8159.2004.00426.x. ... Cardiac arrhythmia surgery was initiated in 1968 with the first successful division of an accessory AV connection for the Wolff ... Nevertheless, the 25-30 years of intense activity in the field of cardiac arrhythmia surgery provided the essential foundation ...
... depths sufficient for thermally ablating arrhythmogenic cardiac tissue to treat ventricular tachycardia and other arrhythmias ... Due to the potential seriousness of cardiac arrhythmias and the limited number of patients that open heart surgery can help, ... An additional significant problem of ventricular tachycardia, as compared with other types of cardiac arrhythmias, is that the ... Because of the potential seriousness of the problem of cardiac arrhythmias, numerous inventors have attempted to solve various ...
The research, which is published in the European Heart Journal, is important because it is thought that arrhythmias can, in ... that the more alcohol consumed the higher was the likelihood of developing abnormal heart rhythms called cardiac arrhythmias. ... the researchers found cardiac arrhythmias in 30.5% of the participants and 25.9% of these arrhythmias were sinus tachycardia, ... Link between alcohol consumption and cardiac arrhythmias. European Society of Cardiology. Journal. European Heart Journal. ...
You just viewed Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial, please rate this material. Dont show this ... Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial. This website allows visitors to see and hear extensive ... Discussion for Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial Log in to participate in the discussions or ... Select this link to add material Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial to Bookmark material or ...
... cryoablation catheters and diagnostic catheters for cardiac ablation, plus catheter accessories including leads, sheaths and ...
This book addresses the tough clinical issues faced by electrophysiologists and cardiologists who treat patients with Cardiac ... Clinical Controversies in Device Therapy for Cardiac Arrhythmias is an essential resource not only for physicians, residents, ... Clinical Controversies in Device Therapy for Cardiac Arrhythmias Editors: Steinberg, Jonathan, Epstein, Andrew (Eds.) ... Focuses on unsettled issues in the field of clinical cardiac electrophysiology. *Presents clinical case studies to illustrate ...
Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum. Mol. Genet. 1995. 4: ... Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature. 2003. 421:634-639. View this ... A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc. Natl. Acad. Sci. U. S. A. 2004. 101:9137-9142. View ... Spectrum of HERG K channel dysfunction in an inherited cardiac arrhythmia. Proc. Natl. Acad. Sci. U. S. A. 1996. 93:2208-2212. ...
Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information ... about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative ...
Cardiac Arrhythmias and Marijuana. Dr. Phillip Leveque Salem-News.com No arrhythmias with 6,000 patients. ... In no case did we ever find a cardiac arrhythmia such Auricular flutter or fibrillation and no ventricular arrhythmias except ... Whether anyone was able to do this I do not know but Bretylium was one of the Cardiac arrhythmia drugs recommended by the ... Bretylium also works in humans for both auricular and ventricular arrhythmias.. I am no longer surprised when someone finds a ...
... July 30, 2018. July 30, 2018 - A team of researchers lead by Mark ... This work took place at IHU Liryc, a research institute dedicated to cardiac arrhythmias, with one of the largest clinical ... physiologists and other specialists to cover all the different aspects of cardiac arrhythmias. Thanks to this collaboration and ... Cardiac diseases are among the biggest causes of death in Europe, and almost half of these deaths are linked to racing heart ...
Congenital arrhythmias may present as arrhythmic sensations, loss of consciousness, cardiac arrest, or sudden death. However, ... Congenital arrhythmias. Congenital arrhythmias usually cause serious arrhythmic attacks. In other respects, your heart might be ... People with congenital arrhythmias may be asymptomatic or the symptoms may not have been diagnosed. Finding carriers is ... If extrasystoles are frequent, they may disturb circulation and cardiac function and must be treated. On rare occasions, ...
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Conclusions: 1) Serious arrhythmias occur in both cardiac and non-cardiac individuals during khat chewing days although they ... 30 were cardiac patients and the other 30 were non-cardiac individuals. All 60 individuals underwent 24 hours holter monitoring ... Results: The non-sustained VT was found on 7 (23.3%) of the 30 cardiac patients on a khat-chewing day compared to 2 patients ( ... Aims: To study the effects of khat chewing on cardiac rhythm. Methods: We selected sixty khat-chewing Yemeni individuals and ...
Diseases : Arrhythmias: Cardiac, Cardiac Mortality , Coronary Artery Disease, High Homocysteine, Myocardial Infarction ... Diseases : Atrial Arrhythmias, Atrial Fibrillation, Atrial Flutter, Cardiac Mortality Anti Therapeutic Actions : ... Diseases : Cardiac Arrhythmias, Heart Failure, Organ Transplantation: Liver, Pulmonary Edema. Additional Keywords : Diseases ... Diseases : Cardiac Arrhythmias, Magnesium Deficiency, Mitral Valve Prolapse. Pharmacological Actions : Antihypertensive Agents ...
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This topic contains 65 study abstracts on Cardiac Arrhythmias indicating that the following substances may be helpful: Omega-3 ... Diseases : Arrhythmias: Cardiac, Cardiac Mortality , Coronary Artery Disease, High Homocysteine, Myocardial Infarction ... Diseases : Atrial Arrhythmias, Atrial Fibrillation, Atrial Flutter, Cardiac Mortality Anti Therapeutic Actions : ... Diseases : Cardiac Arrhythmias, Heart Failure, Organ Transplantation: Liver, Pulmonary Edema. Additional Keywords : Diseases ...
... drugs inducing arrhythmia also disturb normal trafficking and hence alter cardiac electrophys... ... The cardiac action potential is one of the most exquisite examples of regulated protein expression nature presents. The ... proteins that transport ions with great selectivity at the sarcolemma of cardiomyocytes is crucial to maintain regular cardiac ... Editorial: Ion Channel Trafficking and Cardiac Arrhythmias. Marcel A. G. van der Heyden1*, Brian P. Delisle2 and Hugues Abriel3 ...
... underlie hereditary cardiac arrhythmic syndromes such as the type 3 long QT syndrome, cardiac conduction diseases, the Brugada ... Finally, they constitute useful tools for addressing the role of genetic and environmental modifiers on cardiac electrical ... Genetically modified mice rapidly appeared as promising tools for understanding the pathophysiological mechanisms of cardiac ... Genetically modified mice rapidly appeared as promising tools for understanding the pathophysiological mechanisms of cardiac ...
... cardiac arrhythmia). Join the community to connect with others like you and learn about their real-world experiences. ...
The term cardiac arrhythmia covers a very large number of very different conditions. ... Cardiac arrhythmia, also known as cardiac dysrhythmia or irregular heartbeat, is a group of conditions in which the heartbeat ... Arrhythmias & Sudden Cardiac Death - A Publication of the American Heart Association. *ABC News - Sudden Death Arrhythmias Hard ... Experts say that, although arrhythmias are common, not all are fatal.. For Additional Reading:. *Wikipedia - Cardiac arrhythmia ...
Cardiac Arrhythmias - Basic to Complex. 2 day seminar at a 5 star venue with popular Australasian presenter Anne Evans-Murray ... Life threatening arrhythmias. - Ventricular tachycardia, Ventricular fibrillation, P.E.A./A.M.D.. • Cardiac drugs. - Adrenaline ... Miscellaneous Arrhythmias. • Bundle Branch Blocks. • Cardiac Axis shifts. • Pre excitation Syndrome. • Wolf-Parkinson-White ( ... Become one of the few who can easily and quickly analyse any cardiac arrhythmia by following Annes simple systematic approach. ...
Protective effect of crocin against reperfusion-induced cardiac arrhythmias in anaesthetized rats.. Jahanbakhsh Z1, Rasoulian B ... The results suggest a protective role of crocin on cardiac reperfusion arrhythmias which may at least partially be related to ... Protective effect of crocin against reperfusion-induced cardiac arrhythmias in anaesthetized rats ... Protective effect of crocin against reperfusion-induced cardiac arrhythmias in anaesthetized rats ...
An implantable cardiac stimulator integrates the functions of bradycardia and anti-tachycardia pacing-type therapies, and ... 1. An implantable cardiac stimulator, comprising means for detecting cardiac arrhythmias in a predetermined heart rate ... to mean arrhythmias associated with cardiac or other disease, and which are to be contrasted with arrhythmias not associated ... Cardiac arrhythmia analysis system. 1984-09-25. Angel. 128/419D. 4440172. Apparatus for combining pacing and cardioverting ...
  • Cardiac arrythmias, or cardiac rhythm disturbances, are usually diagnosed based on the person's symptoms, medical history, risk factors, a physical exam, and with results from tests and procedures. (sharecare.com)
  • Doctors use diagnostic electrophysiology, a minimally invasive technology to pinpoint the area of tissue causing an arrhythmia. (sharecare.com)
  • DAS-CAM brings together renowned experts, who will cover not only clinical cardiac electrophysiology and device technology, but also the leadership, biostatistics and health economics perspectives. (escardio.org)
  • The programme targets clinical cardiac electrophysiologists with the ambition to improve their knowledge and skills in order to become leading professionals in clinical cardiac electrophysiology. (escardio.org)
  • In such cases, other diagnostic tests are available, such as an exercise stress test, a Holter monitor test (measures cardiovascular electrical activity for 24 to 48 hours), or a cardiac electrophysiology study conducted by inserting a catheter through a blood vessel into the heart's upper and lower chambers. (bumrungrad.com)
  • Electrophysiology is a medical discipline which deals with arrhythmia, a condition in which the heartbeat is irregular being too fast (tachycardia) or. (poliambulanza.it)
  • Diagnosis of an arrhythmia can be done through an EKG or through heart monitors. (sharecare.com)
  • Doctors have pioneered advances in arrhythmia diagnosis and have developed a technology called signal-averaged electrocardiogram. (sharecare.com)
  • 1) An advanced dry-electrode based monitoring system, which will enable continuous long-term, comfortable, non-invasive ECG recordings of cardiac patients presenting sporadic abnormalities of heart rate or rhythm, or for preventive long-term ECG screening schemes of healthy subjects, with cardiac related risks, for early detection and diagnosis of heart disease. (europa.eu)
  • During the meeting all the principal aspects of the different arrhythmias, from epidemiology to physiopathology, electrogenetic mechanisms, diagnosis, prognosis, treatment, pshycological implications and economic costs have been discussed among the numerous experts and participants. (booktopia.com.au)
  • These tests include electrocardiogram (ECG) monitors that can be worn during everyday activities or when arrhythmia symptoms occur to record your heartbeat. (sharecare.com)
  • Some patients don't experience any signs or symptoms and only learn of their arrhythmia during a health check-up or when seeking medical help for an unrelated condition. (bumrungrad.com)
  • The optimal treatment for cardiac arrhythmia depends on the causes, symptoms, location of the problem and its severity. (bumrungrad.com)
  • Symptoms of arrhythmias include palpitations , feeling dizzy , fainting and being short of breath , although having these symptoms does not always mean you have a heart rhythm problem. (focusondisability.co.uk)
  • Arrhythmia Alliance's heart rhythm checklist can help you gather information to discuss with your GP if you have any of these symptoms. (focusondisability.co.uk)
  • When arrhythmias affect heart function, and cause symptoms serious enough to affect your daily life, treatment may be needed. (doctors-hospital.net)
  • You may or may not feel symptoms when the arrhythmia is present. (baptistjax.com)
  • Arrhythmias are caused by problems with the heart's electrical conduction system. (baptistjax.com)
  • Deng aliwang arrhythmias maliaring ikakamate dala at dapat idala da la keng medical emergencies at maliaring mika cardiac arrest la ampong biglaan ing pangamate da. (wikipedia.org)
  • It can also stimulate a heart that has had a sudden cardiac arrest. (memorialhospitaljax.com)
  • These arrhythmias are very likely to lead to cardiac arrest and death. (memorialhospitaljax.com)
  • How many people who have this type of arrhythmia die of sudden cardiac arrest? (doctors-hospital.net)
  • If the doctor believes there may be a cardiac rhythm disturbance, he or she likely will order an electrocardiogram (EKG) for confirmation. (sharecare.com)
  • Most types of cardiac arrhythmia can be diagnosed with an EKG (electrocardiogram) test . (bumrungrad.com)
  • The most effective way to diagnose an arrhythmia is with an electrical recording of your heart rhythm called an electrocardiogram (ECG) . (focusondisability.co.uk)
  • Feeling dizzy or light-headed, a racing heartbeat, shortness of breath, chest pain or fainting may signal cardiac arrhythmia , an irregular heartbeat that requires urgent medical attention. (bumrungrad.com)
  • Cardiac arrhythmia is the medical term for an abnormal heartbeat, whether too fast or too slow. (bumrungrad.com)
  • When a patient's heartbeat becomes irregular, the heart may beat too fast, too slow, skip beats or beat too soon -- all of these come under the definition of cardiac arrhythmia . (bumrungrad.com)
  • Some arrhythmias go undetected during an EKG, particularly when the irregular heartbeat is brief and intermittent. (bumrungrad.com)
  • Arrhythmia is a heartbeat that is too slow, too fast, or irregular. (bumrungrad.com)
  • A cardiac arrhythmia is the medical term for an irregular heartbeat or abnormal heart rhythm. (focusondisability.co.uk)
  • The most common and benign form of arrhythmia is the common "heart palpitation," known technically as sinus arrhythmia. (blakemedicalcenter.com)
  • Sinus arrhythmia is often caused by stress and anxiety. (blakemedicalcenter.com)
  • Sinus arrhythmias are often left untreated. (blakemedicalcenter.com)
  • Ing katayang sinus arrhythmia daleraya ya keng pangkaraniwan a melayari nung nu bagyabagya ing pusu sinikad yang pasikan ampong pamangaina patse mangisnawang palub ampong palual. (wikipedia.org)
  • An implantable cardioverter defibrillator (ICD) is a device that can help change dangerous arrhythmias to healthy ones. (memorialhospitaljax.com)
  • In this innovative postgraduate programme, you will gain the state of the art on cardiac arrhythmology, regulatory and societal dimensions of arrhythmia management, as well as cardiovascular biostatistics, health economics and leadership expertise. (escardio.org)
  • The Diploma of Advanced Studies in Cardiac Arrhythmia Management trains future leaders in arrhythmology to deliver state-of-the-art cardiovascular services in the next decade and beyond. (escardio.org)
  • Sometimes medicines used to treat one type of arrhythmia will cause another type of abnormal heart rhythm. (baptistjax.com)
  • This results in the formation of scar tissue that blocks the electrical impulses that cause the arrhythmia. (memorialhospitaljax.com)
  • Reviewed by Dr. Kriengkrai Jirasirirojanakorn , a board-certified electrophysiologist at the Arrhythmia Center , Bumrungrad International Hospital. (bumrungrad.com)
  • One of the key needs identified by the European Society of Cardiology is the training of future leaders in arrhythmia management and research with a wide view of the societal and economical perspectives. (escardio.org)
  • Conventional treatment for arrhythmia depends on the type involved. (blakemedicalcenter.com)
  • Heart arrhythmias are far too dangerous for self-treatment. (blakemedicalcenter.com)
  • Certain types of arrhythmias don't require medical treatment. (bumrungrad.com)
  • Antiarrhythmic drugs play a central role in the treatment of cardiac arrhythmias in childhood. (thoracickey.com)
  • Treatment of arrhythmias depends on the type, cause, and seriousness of the particular rhythm disturbance you have. (doctors-hospital.net)
  • Prevention & treatment of arrhythmia. (doctors-hospital.net)
  • Available at: http://www.heart.org/HEARTORG/Conditions/Arrhythmia/PreventionTreatmentofArrhythmia/Prevention-Treatment-of-Arrhythmia%5FUCM%5F002026%5FArticle.jsp#.WTAgWevytQJ. (doctors-hospital.net)
  • When an arrhythmia is serious, you may need urgent treatment to restore a normal rhythm. (baptistjax.com)
  • Sometimes, better treatment for your angina or heart failure will lower your chance of having an arrhythmia. (baptistjax.com)
  • Though cardiac arrhythmia is not always preventable, patients can significantly reduce their individual risk by adopting healthy diet and exercise habits and steering clear of the most common arrhythmia triggers: coffee, alcohol, stress and smoking. (bumrungrad.com)
  • To confirm the safety and efficacy of an implantable cardiac monitor (ICM) in patients who require long term cardiac monitoring due to suspected cardiac arrhythmia or unexplained syncope. (genesiscare.com)
  • The removal of the scar tissue underneath the lining of the heart may prevent the arrhythmia from occurring. (memorialhospitaljax.com)
  • Are there any lifestyle changes I can make to help prevent the arrhythmia from recurring? (doctors-hospital.net)
  • This book addresses the tough clinical issues faced by electrophysiologists and cardiologists who treat patients with Cardiac Implantable Electrical Devices (CIEDs) in real-world practice. (springer.com)
  • For our patients with heart rhythm disorders such as atrial fibrillation and ventricular tachycardia, our experienced team of electrophysiologists, cardiac surgeons and advanced practitioners will work together to develop a treatment plan just for you by applying the most innovative and least invasive techniques and procedures available. (mainlinehealth.org)
  • Chemists in the U-M Department of Chemistry and electrophysiologists at the U-M Center for Arrhythmia Research collaborated on the study that will require further examination before it is available in the hospital setting. (nanowerk.com)
  • While most types of arrhythmia are not serious, some predispose a person to complications such as stroke or heart failure. (geni.com)
  • A controlled study found preliminary evidence that vitamin C may help prevent one of the types of arrhythmia (atrial fibrillation) that can follow coronary artery bypass grafting. (medicalcityhospital.com)
  • Those people taking 3.2 grams per day of magnesium chloride (equivalent to 384 mg per day of elemental magnesium) had between 23% and 52% fewer occurrences of specific types of arrhythmia during the six-week study, compared with those taking placebo. (peacehealth.org)
  • if it is an ectopic focus, many types of arrhythmia can result. (academickids.com)
  • Genetically modified mice rapidly appeared as promising tools for understanding the pathophysiological mechanisms of cardiac SCN5A -related arrhythmic syndromes and several mouse models have been established. (frontiersin.org)
  • Mutations in the SCN5A gene, which encodes the α-subunit of the cardiac voltage-gated Na + channel Na V 1.5, underlie hereditary arrhythmic syndromes (so-called cardiac channelopathies). (frontiersin.org)
  • Sudden Arrhythmia Death Syndromes (SADS) are genetic heart conditions that can cause sudden death in young, apparently healthy, people. (geni.com)
  • The Inherited Cardiac Arrhythmia Program at UCLA is a clinical, research, and educational program focused on treating patients with inherited arrhythmia syndromes. (uclahealth.org)
  • However, several disease-associated mutations have been uncovered in human calmodulin genes, all of which are linked to inherited cardiac arrhythmia syndromes. (pnas.org)
  • Recently, several disease-associated mutations have been identified in the CALM genes that are causative of severe cardiac arrhythmia syndromes. (pnas.org)
  • Phenytoin was given intravenously in 37 patients with cardiac arrhythmias-21 had acute myocardial infarction and 16 had other conditions. (bmj.com)
  • There was a favourable response in 18 of the 21 cases with acute myocardial infarction, with a return to sinus rhythm in six of the nine cases with supraventricular arrhythmias, and a return to sinus rhythm in 10 of the 12 cases of ventricular arrhythmias, the remaining two showing a significant reduction in the number of ventricular extra-systoles. (bmj.com)
  • To determine whether drug treatment of asymptomatic ventricular arrhythmias in post-myocardial infarction patients reduced the incidence of sudden cardiac death and total mortality. (clinicaltrials.gov)
  • Treatment of ventricular arrhythmias after myocardial infarction. (springer.com)
  • Arrhythmia suppression for mortality after myocardial infarction. (acc.org)
  • Suppression of asymptomatic or mildly symptomatic ventricular arrhythmias after acute myocardial infarction with encainide, flecainide, or moricizine, would decrease mortality during long-term follow-up. (acc.org)
  • Neither Encainide nor Flecainide should be used in the treatment of patients with asymptomatic or minimally symptomatic ventricular arrhythmia after myocardial infarction, even though these drugs may be effective initially in suppressing ventricular arrhythmia. (acc.org)
  • The suppression of asymptomatic or mildly symptomatic ventricular arrhythmias after myocardial infarction does not improve survival and can increase mortality. (acc.org)
  • Although the bionic cardiac patch has not yet been implanted in animals, "we are interested in identifying collaborators already investigating cardiac patch implantation to treat myocardial infarction in a rodent model," he said. (kurzweilai.net)
  • In contrast, sudden cardiac arrest occurs when the electrical system to the heart malfunctions and suddenly becomes very irregular. (geni.com)
  • However, other heart rhythms are serious and increase risk for life-threatening conditions such as sudden cardiac arrest . (cardiosmart.org)
  • What is Sudden Cardiac Arrest? (cardiosmart.org)
  • Sudden cardiac arrest (SCA) happens when the heart suddenly stops beating. (cardiosmart.org)
  • If you suspect someone is in sudden cardiac arrest, call 911 and start CPR right away. (cardiosmart.org)
  • Sudden cardiac arrest (SCA) remains a major health problem domestically and globally today. (hrsonline.org)
  • Now patients in the US who receive these devices, which help treat heart failure and reduce risk of sudden cardiac arrest, can receive MRI scans if and when they need them. (mainlinehealth.org)
  • OBJECTIVE To examine the association between individual antidiabetic sulfonylureas and outpatient-originating sudden cardiac arrest and ventricular arrhythmia (SCA/VA). (diabetesjournals.org)
  • Every five minutes in Germany alone, a person dies of sudden cardiac arrest or fibrillation, the most common cause of death worldwide. (medicalxpress.com)
  • Figure 1: Example of ventricular fibrillation, a deadly cardiac arrhythmia if not treated within minutes. (scholarpedia.org)
  • The findings are important because it is thought that arrhythmias can, in some circumstances, lead to atrial fibrillation, an irregular heart beat that can result in severe discomfort and, in the long run, more serious consequences such as heart failure and stroke. (eurekalert.org)
  • Heavy drinking over a short period of time (acute alcohol consumption) has been linked to "Holiday heart syndrome" in which people without any previous history of heart problems develop arrhythmias and sometimes atrial fibrillation, but the evidence for this has tended to come from small, retrospective studies. (eurekalert.org)
  • Ventricular Fibrillation or V-Fib, an example of cardiac arrhythmia. (bionity.com)
  • A serious variety of arrhythmia is known as fibrillation. (bionity.com)
  • Atrial fibrillation is when arrhythmia occurs in the heart's top two chambers (atria). (seton.net)
  • Ventricular fibrillation is when arrhythmia takes place in the heart's lower two chambers (ventricles). (seton.net)
  • Without defibrillation to restore the heart's normal rhythm, ventricular fibrillation leads to sudden cardiac death within minutes. (biotronik.com)
  • A cardiac arrhythmia such as atrial fibrillation can be diagnosed in different ways. (sharecare.com)
  • MAs may be manifested either in hemodynamic collapse or in cardiac arrest: The sudden loss of effective blood flow due to atrial fibrillation (AF) with rapid VT leads to hemodynamic collapse, and VT and VF result in cardiac arrest necessitating CPR or electric defibrillation. (medscape.com)
  • Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in the developed world. (nyp.org)
  • Perturbations to this wave, referred to as arrhythmias, can lead to lethal fibrillation if not treated within minutes. (royalsocietypublishing.org)
  • Arrhythmias decrease the ability of the heart to pump blood, and may degenerate into the disorganized, lethal electrical activity known as fibrillation. (royalsocietypublishing.org)
  • Atrial fibrillation (AF) is the most common sustained cardiac rhythm disturbance in the United States. (oncologynurseadvisor.com)
  • One such arrhythmia is atrial or ventricular fibrillation. (google.com)
  • Heretofore, efforts have been directed toward the treatment of arrhythmias, including fibrillation, after they occur. (google.com)
  • Ventricular fibrillation, the most serious type, causes a rapid heart rhythm and is the most common cause of sudden cardiac death. (cardiosmart.org)
  • Atrial Fibrillation After Cardiac Surgery: What's All the Fuss About? (booktopia.com.au)
  • The most common arrhythmia - atrial fibrillation - originates from the heart's upper chambers. (bumrungrad.com)
  • Irregular heart rhythms, or arrhythmias, set the stage for a common, debilitating disorder called atrial fibrillation that puts adults as young as age 40 at risk for fatigue, fainting, cardiac arrest, and even death. (nanowerk.com)
  • However, if the abnormal heart rhythm continues, it can degenerate into a more dangerous arrhythmia known as ventricular fibrillation causing a cardiac arrest and, if untreated, sudden death. (wikipedia.org)
  • 18. Mazhari R, Nuss HB, Armoundas AA, Winslow RL, Marban E. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. (cogprints.org)
  • In transfected cells, the variant allele (Y1102) accelerated channel activation, increasing the likelihood of abnormal cardiac repolarization and arrhythmia. (sciencemag.org)
  • In reentry, cardiac tissue is repetitively excited by a propagating wave circulating around an obstacle (anatomical reentry) or circulating freely in the tissue as a spiral or scroll wave (functional reentry). (scholarpedia.org)
  • Dr. Christini's lab is also investigating cardiac alternans, which is characterized by a beat-to-beat alternation in membrane potential that is known to trigger cardiac reentry in experiments and has been correlated with risk for clinical arrhythmias. (nyp.org)
  • In human cardiomyopathy, anatomical abnormalities such as hypertrophy and fibrosis contribute to the risk of ventricular arrhythmias and sudden death. (jci.org)
  • Ventricular arrhythmias and sudden death are responsible for hundreds of thousands of deaths each year throughout the world. (wiley.com)
  • Dr. Shivkumar is the director of the UCLA Cardiac Arrhythmia Center at the David Geffen School of Medicine at UCLA. (uclahealth.org)
  • The Inherited Cardiac Arrhythmia program is part of the UCLA Cardiac Arrhythmia Center, which provides an advanced and comprehensive list of services and treatment therapies. (uclahealth.org)
  • Congenital arrhythmias usually cause serious arrhythmic attacks. (hus.fi)
  • emphasize on the involvement of autophagy pathways in cardiac ion channel trafficking under disease conditions and the impact of drugs, including antiarrhythmics, on autophagy and subsequent arrhythmic outcomes. (frontiersin.org)
  • To study the instantaneous variations of left ventricular stroke volume induced by sporadic arrhythmic phenomena, such as isolated premature beats, echocardiography (M-mode or 2-D) appears as a safe noninvasive and precise technique allowing to investigate beatto-beat variations of cardiac performance [2-7]. (springer.com)
  • Depending on your type of arrhythmia, treatment may not be necessary. (seton.net)
  • The treatment depends on the type of arrhythmia as well as its underlying causes, which may be located within the heart itself or outside of it. (biotronik.com)
  • However, treatment depends on the type of arrhythmia and each patient. (cardiosmart.org)
  • Nevertheless, the 25-30 years of intense activity in the field of cardiac arrhythmia surgery provided the essential foundation for the development of these catheter techniques and represent one of the most exciting and productive eras in the history of medicine. (nih.gov)
  • The modellers used nine million core hours on GENCI's supercomputers , including Turing, Occigen and Curie , and worked closely with cardiologists as well as with biologists, physiologists and other specialists to cover all the different aspects of cardiac arrhythmias. (hpcwire.com)
  • To foster collaboration, excel discovery, and bring data to the bedside, a new, collaborative quality improvement science network-ACTION (Advanced Cardiac Therapies Improving O. (medworm.com)
  • In these patients with electrical storm refractory to standard therapies, bilateral cardiac sympathetic denervation was safe and effective in acutely suppressing VAs, and preventing SCD. (ahajournals.org)
  • In fact, most of the recent advances in cardiac mapping have focused on improvements in multisite recordings within the heart, with the ability to simultaneous record electrical activation from several hundreds of sites having contributed significantly to our understanding of atrial and ventricular arrhythmias. (cogprints.org)
  • Atrial and ventricular arrhythmias and various degrees of A-V block were reported in patients suffering from subarachnoid hemorrhage. (ahajournals.org)
  • An implantable programmable drug delivery system for injection of a pharmaceutical agent into the peritoneum to treat cardiac arrhythmia is described. (google.com)
  • The rhythm of the heart is set by a small region of cardiac muscle cells in the right atrium called the sinoatrial (SA) node that acts as a spontaneous pacemaker, but is under the control of nerves and circulating hormones that affect the heart rate via a host of control circuits that maintain adequate blood pressure and oxygenation. (scholarpedia.org)
  • Gene therapy to develop a genetically engineered cardiac pacemaker. (cogprints.org)
  • Every cardiac cell has this potential: if it does not receive any impulses from elsewhere, its internal "pacemaker" will fire off an impulse after a certain amount of time. (academickids.com)
  • One useful classification that will be utilized here is reentrant versus non-reentrant arrhythmias. (scholarpedia.org)
  • Thus, there is a strong spatial component to reentrant arrhythmias: either a sufficiently large spatial extent is needed to support the initiation and continuation of the arrhythmia, or an appropriate geometry must be present to allow a reentrant circuit. (scholarpedia.org)
  • Non-reentrant arrhythmias also may have a strong geometric component in which either propagation is blocked at particular anatomical sites or one or more pacemakers form at abnormal (ectopic) locations. (scholarpedia.org)
  • A striking example is the concept of the phase singularity, long known in physics and mathematics, which underlies the induction of reentrant arrhythmias as outlined above [ 12 , 13 ]. (royalsocietypublishing.org)
  • This means that, if a patient has increased risk of ventricular arrhythmias and/or heart failure and the doctor responsible for their care thinks that implantable cardioverter therapy or cardiac resynchronisation therapy is the right treatment, it should be available for use, in line with NICE's recommendations. (nice.org.uk)
  • Hopefully, this will enable us to develop better diagnostics and additional treatments for cardiac arrythmias in the long term. (umcutrecht.nl)
  • Over the years, Earth Clinic readers have sent us many reports about their treatments for Arrhythmia. (earthclinic.com)
  • When arrhythmias are detected early, treatments are more successful and less traumatic. (bumrungrad.com)
  • Sinus arrhythmia is the mild acceleration followed by slowing of the normal rhythm that occurs with breathing. (bionity.com)
  • The most common and benign form of arrhythmia is the common "heart palpitation," known technically as sinus arrhythmia. (medicalcityhospital.com)
  • Sinus arrhythmia is often caused by stress and anxiety. (medicalcityhospital.com)
  • Sinus arrhythmias are often left untreated. (medicalcityhospital.com)
  • After an incidence has been detected, members of the patient's close family are examined to detect possible arrhythmias. (hus.fi)
  • Magnesium supplementation may reduce the incidence of postoperative arrhythmias in pediatric patients undergoing cardiopulmonary bypass. (greenmedinfo.com)
  • Left cardiac sympathetic denervation (LCSD) suppresses ventricular arrhythmias (VAs), and reduces the incidence of sudden cardiac death (SCD). (ahajournals.org)
  • Lower serum concentrations of magnesium were found to be associated with a higher incidence of arrhythmia in a large population study. (peacehealth.org)
  • Anextra systole interrupts normal Atria arrhythmias originate in the atria:sequence of activation of cardiac - Ectopic atria - ectopic impulsesmuscle. (slideshare.net)
  • While a young, healthy person is likely to experience about one ectopic beat per day [ 5 ], patients with compromised cardiac function may have as many as two ectopic beats per minute [ 6 ]. (royalsocietypublishing.org)
  • Despite the paramount importance of ectopic activity in the generation and maintenance of arrhythmias, its origins in cardiac disease have still not been completely characterized [ 7 - 9 ]. (royalsocietypublishing.org)
  • we show here that such analysis is again applicable to cardiac arrhythmogenesis [ 14 - 16 ], and is able to explain the stochastic appearance of ectopic foci via destabilization of the resting electrophysiological state. (royalsocietypublishing.org)
  • Several computer-aided approaches have been presented for automated detection and/or classification of cardiac arrhythmias. (igi-global.com)
  • 36h), using a wrist or arm wearable device with novel ECG sensing techniques and embedded real-time cardiac arrhythmia detection processes. (europa.eu)
  • At the Cardiac Center, we specialize in early detection and repair. (nemours.org)
  • The electrocardiogram (EKG) is a widely used tool for arrhythmia detection, but the unique nature of arrhythmias sometimes requires the use of other testing methods. (bumrungrad.com)
  • Researchers who studied beer drinkers at the Munich Octoberfest have found that the more alcohol consumed the higher was the likelihood of developing abnormal heart rhythms called cardiac arrhythmias. (eurekalert.org)
  • Abnormal heart rhythms, called arrhythmias, cause the heart to beat too fast, slow or unevenly. (cardiosmart.org)
  • Cardiac sympathetic denervation for conventional treatment refractory arrhythmias. (medworm.com)
  • The role of bilateral cardiac sympathetic denervation (BCSD) remains unknown. (ahajournals.org)
  • Surgical BCSD was successfully performed in all patients (50% simultaneously, 50% right cardiac sympathetic denervation after prior unsuccessful LCSD). (ahajournals.org)
  • Of all clinically relevant ictal arrhythmias, ictal asystole has gained much attention as it may cause syncope and subsequent falls, fractures and traffic accidents. (bmj.com)
  • At Rocky Mountain Heart Rhythm Institute, we use cutting-edge procedures to treat congenital heart disease and arrhythmias associated with A-Fib using the method that is best for each patient. (rosemed.com)
  • Surgery for AF is indicated for patients with symptomatic AF who are undergoing concomitant elective cardiac surgery or for selected asymptomatic patients undergoing concomitant elective cardiac surgery with low operative risk. (oncologynurseadvisor.com)
  • Those affected may be asymptomatic, but they may also experience blackouts or even sudden cardiac death. (wikipedia.org)
  • The results suggest a protective role of crocin on cardiac reperfusion arrhythmias which may at least partially be related to stability or even amplification of antioxidant systems. (nih.gov)
  • conducting a microwave signal through said catheter to said cardiac tissue. (google.com)
  • The level of cardiac tissue SOD activity in the "Cr + IR" group animals did not decline significantly compared to rats that were administered crocin alone with no ischemia. (nih.gov)
  • If further tests confirm that MRI measurements of scar tissue accurately predict the risk of arrhythmia-related sudden death, these could become the gold standard for screening who really needs or does not need a defibrillator, says the study s senior author, electrophysiologist Henry Halperin, M.D., a professor of medicine, radiology and biomedical engineering at The Johns Hopkins University School of Medicine and its Heart Institute. (rxpgnews.com)
  • By constructing a universal logic gate using a cardiac cell model, we highlight how the Halting problem therefore could limit what it is possible to predict about cardiac tissue, arrhythmias and re-entry. (microsoft.com)
  • Previous research by others in the field has shown that AF is more prominent in the context of alterations in atrial tissue properties - due to disease, arrhythmias, or age - known as remodeling. (nyp.org)
  • c) Schematic of nanoelectronic scaffold/cardiac tissue resulting from the culturing of cardiac cells within the 3D folded scaffold. (kurzweilai.net)
  • Harvard researchers have designed nanoscale electronic scaffolds (support structures) that can be seeded with cardiac cells to produce a new "bionic" cardiac patch (for replacing damaged cardiac tissue with pre-formed tissue patches). (kurzweilai.net)
  • The bionic cardiac patch can also be a unique platform to study the tissue behavior evolving during some developmental processes, such as aging, ischemia, or differentiation of stem cells into mature cardiac cells. (kurzweilai.net)
  • I think one of the biggest impacts would ultimately be in the area that involves replacement of damaged cardiac tissue with pre-formed tissue patches," Lieber said. (kurzweilai.net)
  • The common form of long QT syndrome (LQTS), Romano-Ward syndrome (RWS), is a heterogeneous, autosomal dominant, genetic disease caused by mutations of ion channel genes involving the cell membranes of the cardiac myocytes. (jci.org)
  • The incorporation of an ion channel gene mutation associated with the long QT syndrome (Q9E-hMiRP1) in a plasmid vector for site-specific arrhythmia gene therapy: in vitro and in vivo feasibility studies. (cogprints.org)
  • SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. (nih.gov)
  • A new study from Brown University, Providence has revealed that individuals with long QT syndrome (LQTS) are at an increased risk of sudden death due to irregular heartbeats, also known as a cardiac arrhythmias. (medindia.net)
  • Long QT syndrome is a rare congenital heart condition characterized by prolonged QT intervals and can cause sudden cardiac deaths. (medindia.net)
  • Our experts have experience diagnosing hereditary arrhythmias such as long QT syndrome and Brugada syndrome. (mainlinehealth.org)
  • Here we report a crystallographic and NMR investigation of several disease mutant CaMs, linked to long-QT syndrome, in complex with the IQ domain of the cardiac voltage-gated calcium channel (Ca V 1.2). (pnas.org)
  • Either dysrhythmia requires medical attention to evaluate the risks associated with the arrhythmia. (bionity.com)
  • Cardiac arrhythmias can manifest themselves in many different ways, and it is still not always possible to determine the mechanism of an arrhythmia. (scholarpedia.org)
  • This mechanism is operated by around twenty different types of molecular "machine" in the external membrane of each cardiac cell. (hpcwire.com)
  • Researchers from Inria and Université de Bordeaux Team within IMB (Institut de Mathématiques de Bordeaux) and IHU LIRYC (L'Institut Hospitalo-Universitaire de Rythmologie et modélisation Cardiaque de Bordeaux), used scientific computing to understand this mechanism, making use of mathematical models that were developed based on the results of experiments on cardiac cells. (hpcwire.com)
  • Thus, myofilament Ca2+ sensitization represents a heretofore unrecognized arrhythmia mechanism. (jci.org)
  • Available data suggest that increased or altered autonomic activity may be the mechanism whereby intracranial hemorrhage produces myocardial damage and cardiac arrhythmias. (ahajournals.org)
  • Figure 3 shows the normal cardiac rhythm on an ECG, where the P wave is associated with the excitation of atria, the QRS complex is associated with the excitation of ventricles, and the T wave is associated with the relaxation of the ventricles. (scholarpedia.org)
  • 2. This Article Has Been Brought to You for Free by www.freud-sigmund.compropagation does not follow the normal Stored in both normal cardiac impulseroute. (slideshare.net)
  • It is well established that a fast (tachy)arrhythmia can be induced via the interaction of the normal cardiac action potential with an additional electrical stimulus [ 1 - 4 ]. (royalsocietypublishing.org)
  • The heart consists of different types of cells such as myocytes, fibroblast, adiopocytes and purkinje fibers, which are all needed for normal cardiac activity. (nanowerk.com)