Phenytoin: An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Tachycardia, Supraventricular: A generic expression for any tachycardia that originates above the BUNDLE OF HIS.Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.Digitalis: A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.Digitalis Glycosides: Glycosides from plants of the genus DIGITALIS. Some of these are useful as cardiotonic and anti-arrhythmia agents. Included also are semi-synthetic derivatives of the naturally occurring glycosides. The term has sometimes been used more broadly to include all CARDIAC GLYCOSIDES, but here is restricted to those related to Digitalis.Electrocardiography: Recording of the moment-to-moment electromotive forces of the HEART as projected onto various sites on the body's surface, delineated as a scalar function of time. The recording is monitored by a tracing on slow moving chart paper or by observing it on a cardioscope, which is a CATHODE RAY TUBE DISPLAY.Parasystole: A cardiac arrhythmia that is caused by interaction of two independently initiated cardiac impulses of different rates from two separate foci. Generally one focus is the SINOATRIAL NODE, the normal pacemaker. The ectopic focus is usually in the HEART VENTRICLE but can be in the HEART ATRIUM or the ATRIOVENTRICULAR NODE. Modulation of the parasystolic rhythm by the sinus rhythm depends on the completeness of entrance block surrounding the parasystolic focus.Heart Conduction System: An impulse-conducting system composed of modified cardiac muscle, having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Models, Cardiovascular: Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.Neural Conduction: The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.LondonHeart Sounds: The sounds heard over the cardiac region produced by the functioning of the heart. There are four distinct sounds: the first occurs at the beginning of SYSTOLE and is heard as a "lubb" sound; the second is produced by the closing of the AORTIC VALVE and PULMONARY VALVE and is heard as a "dupp" sound; the third is produced by vibrations of the ventricular walls when suddenly distended by the rush of blood from the HEART ATRIA; and the fourth is produced by atrial contraction and ventricular filling.Multimedia: Materials, frequently computer applications, that combine some or all of text, sound, graphics, animation, and video into integrated packages. (Thesaurus of ERIC Descriptors, 1994)Heart Auscultation: Act of listening for sounds within the heart.Phonocardiography: Graphic registration of the heart sounds picked up as vibrations and transformed by a piezoelectric crystal microphone into a varying electrical output according to the stresses imposed by the sound waves. The electrical output is amplified by a stethograph amplifier and recorded by a device incorporated into the electrocardiograph or by a multichannel recording machine.Heart Murmurs: Heart sounds caused by vibrations resulting from the flow of blood through the heart. Heart murmurs can be examined by HEART AUSCULTATION, and analyzed by their intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc).Sound: A type of non-ionizing radiation in which energy is transmitted through solid, liquid, or gas as compression waves. Sound (acoustic or sonic) radiation with frequencies above the audible range is classified as ultrasonic. Sound radiation below the audible range is classified as infrasonic.Microwaves: That portion of the electromagnetic spectrum from the UHF (ultrahigh frequency) radio waves and extending into the INFRARED RAYS frequencies.Tachycardia, Ventricular: An abnormally rapid ventricular rhythm usually in excess of 150 beats per minute. It is generated within the ventricle below the BUNDLE OF HIS, either as autonomic impulse formation or reentrant impulse conduction. Depending on the etiology, onset of ventricular tachycardia can be paroxysmal (sudden) or nonparoxysmal, its wide QRS complexes can be uniform or polymorphic, and the ventricular beating may be independent of the atrial beating (AV dissociation).Denture Bases: The part of a denture that overlies the soft tissue and supports the supplied teeth and is supported in turn by abutment teeth or the residual alveolar ridge. It is usually made of resins or metal or their combination.Acrylic ResinsPatents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.TurtlesAtrial Flutter: Rapid, irregular atrial contractions caused by a block of electrical impulse conduction in the right atrium and a reentrant wave front traveling up the inter-atrial septum and down the right atrial free wall or vice versa. Unlike ATRIAL FIBRILLATION which is caused by abnormal impulse generation, typical atrial flutter is caused by abnormal impulse conduction. As in atrial fibrillation, patients with atrial flutter cannot effectively pump blood into the lower chambers of the heart (HEART VENTRICLES).Epicardial Mapping: Recording the locations and measurements of electrical activity in the EPICARDIUM by placing electrodes on the surface of the heart to analyze the patterns of activation and to locate arrhythmogenic sites.Heart: The hollow, muscular organ that maintains the circulation of the blood.Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Electrophysiologic Techniques, Cardiac: Methods to induce and measure electrical activities at specific sites in the heart to diagnose and treat problems with the heart's electrical system.Long QT Syndrome: A condition that is characterized by episodes of fainting (SYNCOPE) and varying degree of ventricular arrhythmia as indicated by the prolonged QT interval. The inherited forms are caused by mutation of genes encoding cardiac ion channel proteins. The two major forms are ROMANO-WARD SYNDROME and JERVELL-LANGE NIELSEN SYNDROME.Adenosine Deaminase: An enzyme that catalyzes the hydrolysis of ADENOSINE to INOSINE with the elimination of AMMONIA.Sarcoplasmic Reticulum: A network of tubules and sacs in the cytoplasm of SKELETAL MUSCLE FIBERS that assist with muscle contraction and relaxation by releasing and storing calcium ions.Calcium-Transporting ATPases: Cation-transporting proteins that utilize the energy of ATP hydrolysis for the transport of CALCIUM. They differ from CALCIUM CHANNELS which allow calcium to pass through a membrane without the use of energy.Nucleoside Deaminases: Catalyze the hydrolysis of nucleosides with the elimination of ammonia.Calsequestrin: Acidic protein found in SARCOPLASMIC RETICULUM that binds calcium to the extent of 700-900 nmoles/mg. It plays the role of sequestering calcium transported to the interior of the intracellular vesicle.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Water-Electrolyte Imbalance: Disturbances in the body's WATER-ELECTROLYTE BALANCE.Hypokalemia: Abnormally low potassium concentration in the blood. It may result from potassium loss by renal secretion or by the gastrointestinal route, as by vomiting or diarrhea. It may be manifested clinically by neuromuscular disorders ranging from weakness to paralysis, by electrocardiographic abnormalities (depression of the T wave and elevation of the U wave), by renal disease, and by gastrointestinal disorders. (Dorland, 27th ed)Electrolytes: Substances that dissociate into two or more ions, to some extent, in water. Solutions of electrolytes thus conduct an electric current and can be decomposed by it (ELECTROLYSIS). (Grant & Hackh's Chemical Dictionary, 5th ed)Hyponatremia: Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)Water-Electrolyte Balance: The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.Clopidol: A very effective anticoccidial agent used in poultry.Literature, ModernDefibrillators, Implantable: Implantable devices which continuously monitor the electrical activity of the heart and automatically detect and terminate ventricular tachycardia (TACHYCARDIA, VENTRICULAR) and VENTRICULAR FIBRILLATION. They consist of an impulse generator, batteries, and electrodes.Pacemaker, Artificial: A device designed to stimulate, by electric impulses, contraction of the heart muscles. It may be temporary (external) or permanent (internal or internal-external).Hepatitis, Infectious Canine: A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.Cardiac Electrophysiology: The study of the electrical activity and characteristics of the HEART; MYOCARDIUM; and CARDIOMYOCYTES.Saudi ArabiaWaste Water: Contaminated water generated as a waste product of human activity.Acupuncture Therapy: Treatment of disease by inserting needles along specific pathways or meridians. The placement varies with the disease being treated. It is sometimes used in conjunction with heat, moxibustion, acupressure, or electric stimulation.TexasAcupuncture: The occupational discipline of the traditional Chinese methods of ACUPUNCTURE THERAPY for treating disease by inserting needles along specific pathways or meridians.

Effect of electrotonic potentials on pacemaker activity of canine Purkinje fibers in relation to parasystole. (1/4675)

Isolated false tendons excised form dog hearts were mounted in a three-chamber tissue bath. Isotonic sucrose solution was perfused in the central chamber to provide a region of depressed conductivity between the fiber segments in chambers 1 and 3, which were perfused with Tyrode's solution. The electrotonic influence of spontaneous or driven responses evoked in chamber 3 during the first half of the spontaneous cycle of a chamber 1 peacemaker delayed the next spontaneous discharge. This effect changed to acceleration when the chamber 3 segment fired during the second half of the spontaneous cycle. We found that subthreshold depolarizing current pulses 50-300 msec applied across the sucrose gap caused similar degrees of delay or acceleration. Furthermore, hyperpolarizing currents caused the reverse pattern. The results indicate that the discharge pattern of a parasystolic focus may be altered by the electrotonic influence of activity in the surrounding tissue. The significance of these findings is considered in relation to the mechanism of production of parasystolic rhythms.  (+info)

Evaluation of the force-frequency relationship as a descriptor of the inotropic state of canine left ventricular myocardium. (2/4675)

The short-term force-frequency characteristics of canine left ventricular myocardium were examined in both isolated and intact preparations by briefly pertubing the frequency of contraction with early extrasystoles. The maximum rate of rise of isometric tension (Fmas) of the isolated trabeculae carneae was potentiated by the introduction of extrasystoles. The ratio of Fmas of potentiated to control beats (force-frequency ratio) was not altered significantly by a change in muscle length. However, exposure of the trabeculae to isoproterenol (10(-7)M) significantly changed the force-frequency ratio obtained in response to a constant frequency perturbation. Similar experiments were performed on chronically instrumented conscious dogs. Left ventricular minor axis diameter was measured with implanted pulse-transit ultrasonic dimension transducers, and intracavitary pressure was measured with a high fidelity micromanometer. Atrial pacing was performed so that the end-diastolic diameters of the beats preceding and following the extrasystole could be made identical. Large increases in the maximum rate of rise of pressure (Pmas) were seen in the contraction after the extrasystole. The ratio of Pmax of the potentiated beat to that of the control beat was not changed by a 9% increase in the end-diastolic diameter, produced by saline infusion. Conversely, isoproterenol significantly altered this relationship in the same manner as in the isolated muscle. Thus, either in vitro or in situ, left ventricular myocardium exhibits large functional changes in response to brief perturbations in rate. The isoproterenol and length data indicate that the force-frequency ratio reflects frequency-dependent changes in the inotropic state, independent of changes in length.  (+info)

Arterial blood gas tensions during upper gastrointestinal endoscopy. (3/4675)

Arterial blood gas tensions were measured before and during upper gastrointestinal endoscopy, with (group I) and without (group 2) sedation with intravenous diazepam. There was a highly significant fall in the PaO2, which occurred in both groups and was therefore not attributable to diazepam. Measurement of FEV, and FVC before endoscopy had no predictive value for those patients whose PaO2 fell the most.  (+info)

Bradykinin promotes ischemic norepinephrine release in guinea pig and human hearts. (4/4675)

We previously reported that bradykinin (BK; 1-1000 nM) facilitates norepinephrine (NE) release from cardiac sympathetic nerves. Because BK production increases in myocardial ischemia, endogenous BK could foster NE release and associated arrhythmias. We tested this hypothesis in guinea pig and human myocardial ischemia models. BK administration (100 nM) markedly enhanced exocytotic and carrier-mediated NE overflow from guinea pig hearts subjected to 10- and 20-min ischemia/reperfusion, respectively. Ventricular fibrillation invariably occurred after 20-min global ischemia; BK prolonged its duration 3-fold. The BK B2 receptor antagonist HOE140 (30 nM) blocked the effects of BK, whereas the B1 receptor antagonist des-Arg9-Leu8-BK (1 microM; i.e., 2.5 x pA2) did not. When serine proteinase inhibitors (500 KIU/ml aprotinin and 100 microg/ml soybean trypsin inhibitor) were used to prevent the formation of endogenous BK, NE overflow and reperfusion arrhythmias were diminished. In contrast, when kininase I and II inhibitors (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid and enalaprilat, each 1 microM) were used to prevent the degradation of endogenous BK, NE overflow and reperfusion arrhythmias were enhanced. B2 receptor blockade abolished these effects but was ineffective if kininases were not inhibited. B2 receptor stimulation, by either exogenous or endogenous BK, also markedly enhanced carrier-mediated NE release in the human myocardial ischemia model; conversely, inhibition of BK biosynthesis diminished ischemic NE release. Because atherosclerotic heart disease impairs endothelial BK production, in myocardial ischemia BK could accumulate at sympathetic nerve endings, thus augmenting exocytotic and carrier-mediated NE release and favoring coronary vasoconstriction and arrhythmias.  (+info)

Heart hypertrophy induced by levothyroxine aggravates ischemic lesions and reperfusion arrhythmias in rats. (5/4675)

AIM: To develop a cardiac hypertrophic model in rats. METHODS: Rats were i.p. levothyroxine 0.5 mg.kg-1.d-1 x 10 d. The action potentials of right papillary muscles were recorded by standard glass-microelectrode technique. The left coronary artery was ligated followed by reperfusion and the apparent infarcted zone (AIZ) was determined by tetracycline fluoresence, and the superoxide dismutase (SOD) activity and malondialdehyde (MDA) product in myocardium were also measured. RESULTS: In the rats treated by levothyroxine, the heart was hypertrophic and the action potential duration (APD) and effective refractory period (ERP) were prolonged, the APD20, APD50, APD90, and ERP were prolonged by 80%, 79%, 74%, and 68%, respectively. No changes in resting potential (RP), action potential amplitude (APA), and Vmax were produced. The incidence of heart arrest (8/8) and the risk of death (67 +/- 0) induced by ischemia-reperfusion in rats with hypertrophic heart was higher than those in normal rats (4/10 and 44 +/- 19, respectively). The AIZ was expanded markedly in hypertrophic heart, and attenuated by lidocaine and propranolol. CONCLUSION: Levothyroxine-induced heart hypertrophy is a suitable model for severe ischemia and arrhythmias in rats.  (+info)

Cardioprotection by opening of the K(ATP) channel in unstable angina. Is this a clinical manifestation of myocardial preconditioning? Results of a randomized study with nicorandil. CESAR 2 investigation. Clinical European studies in angina and revascularization. (6/4675)

AIMS: To assess the anti-ischaemic and anti-arrhythmic effects and overall safety of nicorandil, an ATP sensitive potassium (K+) channel opener, with 'cardioprotective' effects, in patients with unstable angina. METHODS: In a multicentre, randomized, double-blind, parallel-group, placebo-controlled study, oral nicorandil 20 mg twice daily or a matching placebo was administered for a minimum of 48 h to patients admitted with unstable angina. Treatment was standardized to include, where tolerated, oral aspirin, a beta-blocker and diltiazem. Continuous Holter ECG monitoring was performed for 48 h to assess the frequency and duration of transient myocardial ischaemia and any tachyarrhythmia, as the predefined end-points of the study. A pain chart recorded the incidence and severity of chest pain throughout the study period. Patients with myocardial infarction identified retrospectively from troponin-T analysis were excluded. RESULTS: Two hundred and forty-five patients were recruited into the study. Forty-three patients were excluded with an index diagnosis of myocardial infarction, two were not randomized and 12 had unsatisfactory tape data. In the remaining 188 patients, six out of 89 patients (6.7%) on nicorandil experienced an arrhythmia, compared with 17 out of 99 patients (17.2%) on placebo (P=0.04). Three nicorandil patients experienced three runs of non-sustained ventricular tachycardia compared to 31 runs in 10 patients on placebo (P=0.087 patients; P<0.0001 runs). Three nicorandil patients had four runs of supraventricular tachycardia, compared to 15 runs in nine patients on placebo (P=0.14 patients; P=0.017 runs). Eleven (12.4%) patients on nicorandil had 37 episodes of transient myocardial ischaemia (mostly silent) compared with 74 episodes in 21 (21.2%) patients on placebo (P=0.12 patients; P=0.0028 episodes). In the overall safety analysis, which included all patients who received at least one dose of study medication, there were no significant differences in the rates of myocardial infarction or death between the nicorandil or placebo-treated groups. CONCLUSIONS: Nicorandil, added to aggressive anti-anginal treatment for unstable angina, reduces transient myocardial ischaemia, non-sustained ventricular, and supraventricular arrhythmia compared to placebo. The anti-arrhythmic activity with nicorandil is probably a secondary effect resulting from its anti-ischaemic action and we suggest that this may be related to its effect on the ATP sensitive potassium channel causing pharmacological preconditioning.  (+info)

Superiority of ibutilide (a new class III agent) over DL-sotalol in converting atrial flutter and atrial fibrillation. The Ibutilide/Sotalol Comparator Study Group. (7/4675)

OBJECTIVE: To compare the efficacy and safety of a single dose of ibutilide, a new class III antiarrhythmic drug, with that of DL-sotalol in terminating chronic atrial fibrillation or flutter in haemodynamically stable patients. DESIGN: Double blind, randomised study. SETTING: 43 European hospitals. PATIENTS: 308 patients (mean age 60 years, 70% men, 48% with heart disease) with sustained atrial fibrillation (n = 251) or atrial flutter (n = 57) (duration three hours to 45 days) were randomised to three groups to receive a 10 minute infusion of 1 mg ibutilide (n = 99), 2 mg ibutilide (n = 106), or 1.5 mg/kg DL-sotalol (n = 103). Infusion was discontinued at termination of the arrhythmia. MAIN OUTCOME MEASURE: Successful conversion of atrial fibrillation or flutter, defined as termination of arrhythmia within one hour of treatment. RESULTS: Both drugs were more effective against atrial flutter than against atrial fibrillation. Ibutilide was superior to DL-sotalol for treating atrial flutter (70% and 56% v 19%), while the high dose of ibutilide was more effective for treating atrial fibrillation than DL-sotalol (44% v 11%) and the lower dose of ibutilide (44% v 20%, p < 0.01). The mean (SD) time to arrhythmia termination was 13 (7) minutes with 2 mg ibutilide, 19 (15) minutes with 1 mg ibutilide, and 25 (17) minutes with DL-sotalol. In all patients, the duration of arrhythmia before treatment was a predictor of arrhythmia termination, although this was less obvious in the group that received 2 mg ibutilide. This dose converted almost 48% of atrial fibrillation that was present for more than 30 days. Concomitant use of digitalis or nifedipine and prolongation of the QTc interval were not predictive of arrhythmia termination. Bradycardia (6.5%) and hypotension (3.7%) were more common side effects with DL-sotalol. Of 211 patients given ibutilide, two (0.9%) who received the higher dose developed polymorphic ventricular tachycardia, one of whom required direct current cardioversion. CONCLUSION: Ibutilide (given in 1 or 2 mg doses over 10 minutes) is highly effective for rapidly terminating persistent atrial fibrillation or atrial flutter. This new class III drug, under monitored conditions, is a potential alternative to currently available cardioversion options.  (+info)

Overexpression of a human potassium channel suppresses cardiac hyperexcitability in rabbit ventricular myocytes. (8/4675)

The high incidence of sudden death in heart failure may reflect abnormalities of repolarization and heightened susceptibility to arrhythmogenic early afterdepolarizations (EADs). We hypothesized that overexpression of the human K+ channel HERG (human ether-a-go-go-related gene) could enhance repolarization and suppress EADs. Adult rabbit ventricular myocytes were maintained in primary culture, which suffices to prolong action potentials and predisposes to EADs. To achieve efficient gene transfer, we created AdHERG, a recombinant adenovirus containing the HERG gene driven by a Rous sarcoma virus (RSV) promoter. The virally expressed HERG current exhibited pharmacologic and kinetic properties like those of native IKr. Transient outward currents in AdHERG-infected myocytes were similar in magnitude to those in control cells, while stimulated action potentials (0.2 Hz, 37 degrees C) were abbreviated compared with controls. The occurrence of EADs during a train of action potentials was reduced by more than fourfold, and the relative refractory period was increased in AdHERG-infected myocytes compared with control cells. Gene transfer of delayed rectifier potassium channels represents a novel and effective strategy to suppress arrhythmias caused by unstable repolarization.  (+info)

*Cardiac Arrhythmia Suppression Trial

The second Cardiac Arrhythmia Suppression Trial (CAST II) modified the enrollment criteria to include patients at higher risk ... The Cardiac Arrhythmia Suppression Trial (CAST) was a double-blind, randomized, controlled study designed to test the ... A possible explanation for increased mortality in the Cardiac Arrhythmia Suppression Trial (CAST)". Circulation. 90 (6): 2843- ... Clinical trial number NCT00000526 for "Cardiac Arrhythmia Suppression Trial (CAST)" at ClinicalTrials.gov. ...

*Mechanosensitive channels

Some of these pathologies include cardiac arrhythmia (such as atrial fibrillation), cardiac hypertrophy, Duchenne muscular ... Honore, E., Patel, A. A., Kohl, P., Franz, M. R. & Sachs, F. in Cardiac Mechano-Electric Feedback and Arrhythmias: From Pipette ... Peyronnet R, Nerbonne JM, Kohl P (2016). "Cardiac mechano-gated ion channels and arrhythmias". Circ. Res. 118: 311-29. doi: ... Cardiac arrhythmias Hypertension. Mechanosensation Large-conductance mechanosensitive channel Voltage-gated ion channels Ligand ...

*Prostacyclin receptor

... severe cardiac arrhythmias; congenital or acquired heart valve defects; increased risk of bleeding; a history of myocardial ... Furthermore, IP(-/-) mice on a high salt diet develop significantly higher levels of hypertension, cardiac fibrosis, and ... For example, the IP agonist iloprost is contraindicated in patients with unstable angina; decompensated cardiac failure (unless ... "A Comparison of Inhaled Nitric Oxide Versus Inhaled Epoprostenol for Acute Pulmonary Hypertension Following Cardiac Surgery". ...

*Electrophysiology study

Management of Cardiac Arrhythmias. Contemporary cardiology. Hanumana Press. pp. 123-140. doi:10.1007/978-1-60761-161-5. ISBN ... During EPS, sinus rhythm as well as supraventricular and ventricular arrhythmias of baseline cardiac intervals is recorded. The ... Last, the electrophysiologist may administer various drugs (proarrhythmic agents) to induce arrhythmia. If the arrhythmia is ... A cardiac electrophysiology study (EP test or EP study) is a minimally invasive procedure that tests the electrical conduction ...

*Cardiac rhythm problems during space flight

While there are no definitive data showing that long-duration space flight is associated with cardiac arrhythmias, there are ... At least two potential risk factors for arrhythmias have been reported either during or immediately after space flight: cardiac ... The incidence and clinical significance of cardiac arrhythmias during long-term exposure to microgravity experienced on the ... It is unknown whether long-duration exposure to microgravity itself may precipitate cardiac arrhythmias. Based on observations ...

*Cameron Health

Jaeger, Fredrick J. "Cardiac Arrhythmias". Cleveland Clinic. Retrieved 19 January 2010. Graham-Rowe, Duncan (November 26, 2008 ... In addition to the risks inherent in cardiac surgery, the leads have themselves proved to be a weakness in some ICD designs. ... When an ICD detects a serious arrhythmia, it issues an electrical impulse to the heart muscle, of a magnitude sufficient to ... These patients tended to have genetic or other conditions predisposing them to sudden cardiac death due to a failure of the ...

*Procainamide

... works as an anti-arrhythmic agent and is used to treat cardiac arrhythmia. It induces rapid block of the ... Procainamide is a medication of the antiarrhythmic class used for the treatment of cardiac arrhythmias. It is classified by the ... Gould, Lawrence A. (ed.) (1983). Drug treatment of cardiac arrhythmias. Mount Kisco: Futura Publishing Company. p. 74. ISBN ... by Lawrence A. (1983). Drug treatment of cardiac arrhythmias. Mount Kisco: Futura Publishing Company. pp. 73-74. ISBN ...

*Celivarone

Cardiac arrhythmia is any abnormality in the electrical activity of the heart. Arrhythmias range from mild to severe, sometimes ... The causes of cardiac arrhythmias are numerous, from structural changes in the conduction system (the sinoatrial and ... Hoffman, BF (September 1966). "Physiological Basis of Cardiac Arrhythmias. II". Modern Concepts of Cardiovascular Disease. 35 ( ... KVLQT1 Mutations Cause Cardiac Arrhythmias". Nature Genetics. 12 (1): 17-23. doi:10.1038/ng0196-17. PMID 8528244. Abbott, GW; ...

*Antiarrhythmic agent

Action potential Cardiac action potential Cardiac Arrhythmia Suppression Trial (CAST) Electrocardiogram Proarrhythmic agent ... In Symposium on Cardiac Arrhythmias (Eds. Sandoe E, Flensted- Jensen E, Olsen KH). Astra, Elsinore. Denmark (1970) Kloner RA ( ... cardiac arrhythmias), such as atrial fibrillation, atrial flutter, ventricular tachycardia, and ventricular fibrillation. Many ... Class I agents are grouped by what effect they have on the Na+ channel, and what effect they have on cardiac action potentials ...

*Pathophysiology of asthma

"CHAPTER 33 - Therapy for Cardiac Arrhythmias." 2007. Elsevier. Middleton's Allergy Principles & Practice, N. F. Adkinson, B. S ...

*Afterdepolarization

Katzung, B: Basic and Clinical Pharmacology (10th ed.), chapter 14: "Agents Used in Cardiac Arrhythmias", The McGraw-Hill ... Afterdepolarizations may lead to cardiac arrhythmias. Early afterdepolarizations (EADs) occur with abnormal depolarization ... Early afterdepolarizations can result in torsades de pointes, tachycardia, and other arrhythmias. EADs can be potentiated by ... Cranefield, PF: The Conduction of the Cardiac Impulse. New York, Future Publishing Co. 1975 Nelson Spruston, "Pyramidal Neurons ...

*Premature ventricular contraction

Magnesium in Cardiac Arrhythmias (MAGICA) Investigators". Journal of the American College of Cardiology. 29 (5): 1028-34. doi: ... A possible explanation for increased mortality in the Cardiac Arrhythmia Suppression Trial (CAST)". Circulation. 90 (6): 2843- ... "HRS Expert Consensus Statement on the Diagnosis and Management of Arrhythmias Associated With Cardiac Sarcoidosis", Heart ... It is advised for people with ventricular dysfunction and frequent arrhythmias or very frequent PVC (>20% in 24 h) and normal ...

*Crush syndrome

Even so, cardiac arrhythmias may develop; electrocardiographic monitoring is advised, and specific treatment begun promptly. " ... "pediatric patients and patients with history of cardiac or renal dysfunction." If the patient cannot be fluid loaded, this may ...

*László Szekeres

Congress of the European section of ISHR in Szeged he was honoured by denominating the symposia dealing with cardiac arrhythmia ... Experimental Cardiac Arrhythmias and Antiarrhythmic Drugs. (Monograph) Budapest: Akadémiai Kiadó; 1971. p. 1-448. 5. Vaughan ... The results and data on experimental cardiac arrhythmias and antiarrhythmic drugs were summarized with his co-authorship in the ... He became interested in experimental cardiac arrhythmia and antiarrhythmic drugs, area rather unexplored at that time. Worked ...

*Flecainide

The Cardiac Arrhythmia Suppression Trial". N Engl J Med. 324 (12): 781-8. doi:10.1056/NEJM199103213241201. PMID 1900101. ... Cardiac Arrhythmia Suppression Trial (CAST) Investigators (1989). "Preliminary report: effect of encainide and flecainide on ... Results of a medical study known as the Cardiac Arrhythmia Suppression Trial (CAST) demonstrated that patients with structural ... notably the Cardiac Arrhythmia Suppression Trial) have shown an increased mortality when flecainide is used to suppress ...

*Junctional escape beat

Ectopic beat Junctional rhythm Abedin, Zainul; Conner, Robert (2012). Interpretation of Cardiac Arrhythmias: Self-Assessment ... Junctional rhythms (if a bradycardia) can cause decreased cardiac output. Therefore, the person may exhibit signs and symptoms ...

*Re-entry ventricular arrhythmia

Mechanisms of Cardiac Arrhythmias and Conduction Disturbances. In V. Fuster, R.A. Walsh, R.A. Harrington (Eds). ... AV reentrant tachycardia AV nodal reentrant tachycardia "Cardiac Arrhythmias". Retrieved 2007-07-21. Am J Cardiol. 1984 Jul 30; ... Re-entry ventricular arrhythmia is a type of paroxysmal tachycardia occurring in the ventricle where the cause of the ... or bradycardia are potential causes of functionally defined re-entry due to changes in the properties of the cardiac tissue's ...

*Heart murmur

"Blaufuss Multimedia - Heart Sounds and Cardiac Arrhythmias". Medical Multimedia Laboratories. Retrieved 2 August 2013. Topi, ... The cooing dove murmur is a cardiac murmur with a musical quality (high pitched - hence the name) and is associated with aortic ... Mitral stenosis typically presents as a diastolic low-pitched decrescendo murmur best heard at the cardiac apex in the left ... and Timing in the cardiac cycle. The use of two simple mnemonics may help differentiate systolic and diastolic murmurs; PASS ...

*Long QT syndrome

Shinnawi R, Gepstein L; Gepstein (September 2014). "iPS Cell Modeling of Inherited Cardiac Arrhythmias". Curr Treat Options ... arrhythmia prevention and arrhythmia termination. Arrhythmia suppression involves the use of medications or surgical procedures ... Arrhythmia termination involves stopping a life-threatening arrhythmia once it has already occurred. One effective form of ... Cardiac action potential Short QT syndrome "Long QT syndrome". Genetic and Rare Diseases Information Center (GARD) - an NCATS ...

*Harvey N. Middleton

... (March 1949). "The Diagnosis and Management of Cardiac Arrhythmias". Journal of the National Medical ... "The Diagnosis and Management of Cardiac Arrhythmias", Journal of the National Medical Association (March 1949) "The Value of ... 5 (1). Costumed interpreters greeted visitors and provided insight into cardiac medicine and the city's race relations in the ...

*Myocardial infarction complications

ISBN 0-7817-2486-4. Sung, Ruey J.; Michael R. Lauer (2000). Fundamental Approaches to the Management of Cardiac Arrhythmias. ... Podrid, Philip J.; Peter R. Kowey (2001). Cardiac Arrhythmia: Mechanisms, Diagnosis, and Management. Lippincott Williams & ... Cardiogenic shock is defined as a hemodynamic state in which the heart cannot produce enough of a cardiac output to supply an ... Yip HK, Wu CJ, Chang HW, Wang CP, Cheng CI, Chua S, Chen MC (2003). "Cardiac rupture complicating acute myocardial infarction ...

*List of OMIM disorder codes

SDHD Cardiac arrhythmia, ankyrin-B-related; 600919; ANK2 Cardiac conduction defect, nonspecific; 612838; SCN1B ... cardiac variant; 301500; GLA Factor V and factor VIII, combined deficiency of; 227300; MCFD2 Factor V deficiency; 227400; F5 ... cardiac valvular form; 225320; COL1A2 Ehlers-Danlos syndrome, hypermobility type; 130020; TNXB Ehlers-Danlos syndrome, ...

*Earl Dodge

However, he died of cardiac arrhythmia nearly a year before the election, at the Denver International Airport while waiting to ... Doctors confirmed it was cardiac arrhythmia. He died on November 7, 2007. Culver, Virginia (2007-11-09). "Presidential ...

*AZD1305

... is an experimental drug candidate that is under investigation for the management and reversal of cardiac arrhythmias, ... Sanguinetti, Michael C.; Tristani-Firouzi, Martin (2006). "HERG potassium channels and cardiac arrhythmia". Nature. 440 (7083 ... is a form of cardiac arrhythmia that arises with disorganized and rapid action potentials conducted through the atria, ... used for the maintenance of AF are often accompanied with the risk of developing ventricular pro-arrhythmias, as they are often ...

*HERG

Sanguinetti MC, Tristani-Firouzi M (March 2006). "hERG potassium channels and cardiac arrhythmia". Nature. 440 (7083): 463-9. ... Sanguinetti MC, Tristani-Firouzi M (2006). "hERG potassium channels and cardiac arrhythmia". Nature. 440 (7083): 463-9. doi: ... that can lead to the risk of potentially fatal cardiac arrhythmias (e.g., torsades de pointes), due to repolarization ... "A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel". Cell. 81 ( ...

*Atrioventricular node

The cardiac conduction system (and AV node part of it) coordinates myocyte mechanical activity. A wave of excitation spreads ... This also protects the ventricles from excessively fast rate response to atrial arrhythmias (see below). AV conduction during ... The atrioventricular node delays impulses by approximately 0.12s. This delay in the cardiac pulse is extremely important: It ... BMP (Bone morphogenetic protein) cell signaling plays a key role in diverse aspects of cardiac differentiation and ...
Booktopia has Cardiac Arrhythmias 2003, Proceedings of the 8th International Workshop on Cardiac Arrhythmias by Antonio Raviele. Buy a discounted Hardcover of Cardiac Arrhythmias 2003 online from Australias leading online bookstore.
About 20 years ago, the first traditional cardiac EP devices were designed and they were meant for treating less complex arrhythmias. As it became more and more obvious that there is an actual need for a device that can read more complex arrhythmias, savvy businessman Ken Londoner decided to invest in developing a system that can treat atrial fibrillation and ventricular tachyarrhythmia, and thus help millions of people. Today, not only have they developed a device that is able to read more complex arrhythmias, but have also found a way to get rid of the non-biological noise. ...
Defibrillation is a treatment for life-threatening cardiac dysrhythmias, specifically ventricular fibrillation (VF) and non-perfusing ventricular tachycardia (VT). A defibrillator delivers a dose of electric current (often called a countershock) to the heart. This depolarizes a large amount of the heart muscle, ending the dysrhythmia. Subsequently, the bodys natural pacemaker in the sinoatrial node of the heart is able to re-establish normal sinus rhythm. In contrast to defibrillation, synchronized electrical cardioversion is an electrical shock delivered in synchrony to the cardiac cycle. Although the person may still be critically ill, cardioversion normally aims to end poorly perfusing cardiac dysrhythmias, such as supraventricular tachycardia. Defibrillators can be external, transvenous, or implanted (implantable cardioverter-defibrillator), depending on the type of device used or needed. Some external units, known as automated external defibrillators (AEDs), automate the diagnosis of ...
The AVID Study was a multicenter, randomized comparison of antiarrhythmic drug treatment (mostly amiodarone) and ICD implantation to manage patients resuscitated from life-threatening ventricular arrhythmias not due to transient or reversible causes. Eligible arrhythmias included 1) VF; 2) sustained ventricular tachycardia (VT) with syncope; and 3) sustained VT with an ejection fraction of ≤0.40, and symptoms suggestive of severe hemodynamic compromise. The trial design and primary end-point paper have been published (19,20). It is interesting to note that the location of index ventricular arrhythmia presentation was not a factor in eligibility for randomization. Each participating institution had approval from its Institutional Review Board for conduct of the study. All patients who underwent randomization gave written informed consent.. As part of the study design, a registry was maintained of all patients with sustained ventricular arrhythmias at each study site. It included not only ...
Arrhythmias that originate in the ventricular myocardium or His-Purkinje system include premature ventricular beats, ventricular tachycardias that can be sustained or nonsustained, and ventricular fibrillation. Arrhythmia may emerge from a focus of myocardial or Purkinje cells capable of automaticity, or triggered automaticity, or from reentry through areas of scar or a diseased Purkinje system. Ventricular arrhythmias are often associated with structural heart disease and are an important cause of sudden death (Chap. 327). They also occur in some structurally normal hearts, in which case they are usually benign. Evaluation and management are guided by the risk of arrhythmic death, which is assessed based on symptoms, type of arrhythmia, and associated underlying heart disease. ...
Many cerebral strokes are due to undetected cardiac arrhythmias. Any rapid cardiac arrhythmia may induce neurological symptoms as hemiplegia, aphasia, or psychosis. Twenty-eight patients who developed neurological disturbances following various cardiac arrhythmias were carefully studied. Most of these were due to rapid atrial fibrillation or supraventricular tachycardia. Undetected bradycardia due to vagotonia was a common cause of transient episodes of unconsciousness.. The cerebral blood flow was measured in animals when cardiac arrhythmias were induced. It was noted that frequent premature systoles reduced the cerebral blood flow 7 to 12%. More frequent runs of premature systoles caused a greater reduction. Supraventricular ...
A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.
A cardiac event and arrhythmia detection system and method detects arrhythmic cardiac activity or other information from an electrogram signal of a heart. The system senses the electrogram signal through an electrogram lead, preliminarily processes the signal, and converts it to a plurality of discrete digital signals, each of which represents the magnitude of the electrogram signal at a prescribed sample time. The discrete digital signals are applied to both a cardiac event detector and a morphology detector. The morphology detector detects selected changes in the morphology (shape) of the electrogram signal, wherein such changes automatically control the sensitivity (gain and/or threshold) used to detect cardiac events. The occurrence of a prescribed amount of change in the detected morphology over time indicates the occurrence of a prescribed arrhythmic cardiac condition.
To evaluate the effects of hypertension on cardiac hypertrophy, on myocardial structure, and on ventricular arrhythmias, 27 3-month-old spontaneously hypertensive rats were treated with enalapril (10 mg/kg) daily for 11 months and compared with 26 untreated control rats. Systolic arterial pressure was significantly decreased in treated rats, and at the end of the experiment, it was 199 +/- 3 mm Hg (treated) versus 237 +/- 3 mm Hg (controls) (p less than 0.001). At this time, spontaneous arrhythmias and induced arrhythmias either by programmed electrical stimulation (train of stimuli +1 or 2 extrastimuli) or by trains of eight stimuli at decreasing coupling intervals were observed in isolated heart preparations. Comparing enalapril-treated and control rats, spontaneous arrhythmias (9 of 27 versus 20 of 26, respectively; p less than 0.01), programmed stimulation-induced arrhythmias (3 of 26 versus 12 of 23, respectively; p less than 0.01), and trains of stimuli-induced arrhythmias (4 of 26 versus ...
Background-Genetic predisposition to life-threatening cardiac arrhythmias such as in congenital long-QT syndrome (LQTS) and catecholaminergic polymorphic ventricular tachycardia (CPVT) represent treatable causes of sudden cardiac death in young adults and children. Recently, mutations in calmodulin (CALM1, CALM2) have been associated with severe forms of LQTS and CPVT, with life-threatening arrhythmias occurring very early in life. Additional mutation-positive cases are needed to discern genotype-phenotype correlations associated with calmodulin mutations. Methods and Results-We employed conventional and next-generation sequencing approaches including exome analysis in genotype-negative LQTS probands. We identified five novel de novo missense mutations in CALM2 in three subjects with LQTS (p.N98S, p.N98I, p.D134H) and two subjects with clinical features of both LQTS and CPVT (p.D132E, p.Q136P). Age of onset of major symptoms (syncope or cardiac arrest) ranged from 1-9 years. Three of five ...
Objectives Our previous study shows that Microvolt T-wave alternans (MTWA) testing has significant value for the prediction of mortality or severe arrhythmic events in a population of individuals with implanted ICDs. Whether MTWA is an accurate predictor of ventricular tachyarrhythmic events in patients without ICDs remains unclear. We conducted a meta-analysis of the predictive value of MTWA testing for mortality and severe arrhythmic events in patients with cardiac dysfunction but without implanted ICDs.. ...
Clinical CharacteristicsThe Students t-test was used to compare the age, sex, height and weight, and initial blood pressure, heart rate, respiratory rate,
Cardiac arrhythmias are becoming one of the major health care problem in the world, causing numerous serious disease conditions including stroke and sudden cardiac death. Furthermore, cardiac arrhythmias are intimately related to the signaling ability of cardiac cells, and are caused by signaling defects. Consequently, modeling the electrical activity of the heart, and the complex signaling models that subtend dangerous arrhythmias such as tachycardia and fibrillation, necessitates a quantitative model of action potential (AP) propagation. Yet, many electrophysiological models, which accurately reproduce dynamical characteristic of the action potential in cells, have been introduced. However, these models are very complex and are very time consuming computationally. Consequently, a large amount of research is consecrated to design models with less computational complexity. This paper is presenting a new model for analyzing the propagation of ionic concentrations and electrical potential in space and
TY - JOUR. T1 - Pleiotropic Effects of Myocardial MMP-9 Inhibition to Prevent Ventricular Arrhythmia. AU - Weng, Ching Hui. AU - Chung, Fa Po. AU - Chen, Yao Chang. AU - Lin, Shien Fong. AU - Huang, Po Hsun. AU - Kuo, Terry B J. AU - Hsu, Wei Hsuan. AU - Su, Cheng Wen. AU - Sung, Yen Ling. AU - Lin, Yenn Jiang. AU - Chang, Shih Lin. AU - Chou, Li Wei. AU - Yeh, Hung I.. AU - Chen, Yi-Jen. AU - Hong, Yi Ren. AU - Chen, Shih Ann. AU - Hu, Yu Feng. PY - 2016/12/14. Y1 - 2016/12/14. N2 - Observational studies have established a strong association between matrix metalloproteinase-9 (MMP-9) and ventricular arrhythmia. However, whether MMP-9 has a causal link to ventricular arrhythmia, as well as the underlying mechanism, remains unclear. Here, we investigated the mechanistic involvement of myocardial MMP-9 in the pathophysiology of ventricular arrhythmia. Increased levels of myocardial MMP-9 are linked to ventricular arrhythmia attacks after angiotensin II (Ang II) treatment. MMP-9-deficient mice were ...
Abstract: Recently, arrhythmogenic condition has attracted special attention of scientists in the field of different disciplines because sudden cardiac death is often caused by cardiac arrhythmia. Arrhythmias can have different underlying causes. But the underlying mechanism of arrhythmia is not fully understood due to cardiac complexity. As is well known, one particular group of arrhythmias is often associated with the afterdepolarizations. So far, afterdepolarizations have been studied mainly in isolated cardiac cells. The question how the afterdepolarization is produced at a tissue level has not been widely studied yet. In this paper, we use the model of human heart to study how spiral wave or other wave patterns induces the afterdepolarizations in two-dimensional myocardial tissue. We try to obtain the instantaneous spatial distribution of afterdepolarizations by changing the L-type calcium and fast potassium conductance. In order to avoid bringing in afterdepolarizations, the applied ...
Causes of Arrhythmias (Heart Rhythm Disturbances) can depend on each individual situation. Learn about causes of Arrhythmias (Heart Rhythm Disturbances) and find symptoms, diagnosis, and many types of smart treatments for Arrhythmias (Heart Rhythm Disturbances) at FoundHealth.
Sudden cardiac death (SCD) is responsible for 300,000-450,000 deaths per year in the United States. While it is well known that patients with both ischemic and non-ischemic cardiomyopathy (ICM, NICM) are at increased risk for SCD, there is little beyond ejection fraction which has proven useful as a noninvasive predictor to risk stratify these patients.. Myocardial scar has been validated as an arrhythmic substrate in ischemic populations; the majority of successful ablations for lethal ventricular arrhythmias are performed on tissues in peri-infarct regions. Scar provides an anatomic electrical boundary where peri-infarct zones may lead to areas of slow conduction due to the disruption of inter-myocyte electrical conduction.. Myocardial scar is a less organized collagen deposition which disrupts the typical cardiac extracellular matrix. The collagen matrix provides mechanical support to the myocardium dictating ventricular shape, size and stiffness. While typically relatively dormant, the ...
Sudden cardiac death (SCD) is responsible for 300,000-450,000 deaths per year in the United States. While it is well known that patients with both ischemic and non-ischemic cardiomyopathy (ICM, NICM) are at increased risk for SCD, there is little beyond ejection fraction which has proven useful as a noninvasive predictor to risk stratify these patients.. Myocardial scar has been validated as an arrhythmic substrate in ischemic populations; the majority of successful ablations for lethal ventricular arrhythmias are performed on tissues in peri-infarct regions. Scar provides an anatomic electrical boundary where peri-infarct zones may lead to areas of slow conduction due to the disruption of inter-myocyte electrical conduction.. Myocardial scar is a less organized collagen deposition which disrupts the typical cardiac extracellular matrix. The collagen matrix provides mechanical support to the myocardium dictating ventricular shape, size and stiffness. While typically relatively dormant, the ...
Sudden cardiac arrest (SCA) from ventricular arrhythmias affects over 400,000 individuals/year in the U.S. alone and has a dismal survival rate (1). Although reduced left ventricular systolic function (i.e., left ventricular ejection fraction) (2) and symptomatic heart failure (i.e., congestive heart failure) (3) are the major predictors of risk for SCA, they are more sensitive than they are specific. Thus, their primacy in guidelines for implantable cardioverter-defibrillators (ICDs) might lead to potentially unnecessary implantations (1). This motivates the identification of markers for the pathophysiology of ventricular arrhythmias that can improve indices for ICD insertion.. Several candidates exist. Inducing sustained ventricular arrhythmias at electrophysiologic study (EPS) was historically the gold standard but has become tarnished of late. Certainly, SCA is more frequent in ischemic cardiomyopathy patients with positive EPS, yet those with negative EPS still have a substantial arrhythmic ...
Arrhythmia. National Heart, Lung, and Blood Institute website. Available at: https://www.nhlbi.nih.gov/health-topics/arrhythmia. Accessed January 4, 2019.. Atrial fibrillation. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115288/Atrial-fibrillation. Updated August 22, 2018. Accessed January 4, 2019.. Atrial flutter. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T115251/Atrial-flutter. Updated February 22, 2017. Accessed January 4, 2019.. Atrioventricular (AV) conduction disorders. EBSCO DynaMed Plus website. Available at:http://www.dynamed.com/topics/dmp~AN~T907302/Atrioventricular-AV-conduction-disorders. Updated November 27, 2017. Accessed January 4, 2019.. Understanding your risk for arrhythmia. American Heart Association website. Available at: https://www.heart.org/en/health-topics/arrhythmia/understand-your-risk-for-arrhythmia. Accessed January 4, 2019.. Ventricular arrhythmias. EBSCO DynaMed Plus website. Available ...
Diagnosing arrhythmia can be quite difficult because the medical condition may sometimes produce few symptoms. Many physicians diagnose an arrhythmia by examining the patients medical and family history and by performing physical examinations. To diagnose an arrhythmia, physicians usually ask patients to describe their symptoms. A physician may ask the patient if he or she feels thumping in his or her chest and whether the patient feels dizzy or lightheaded. A physician may also diagnose an arrhythmia by asking a patient if his or her family has a history of arrhythmia or other heart diseases. The doctor may ask the patient if he or she is under medications including over the counter medicines and supplements. A physical exam can also serve as an important diagnostic procedure for arrhythmia. During the physical exam, the doctor will examine the patients heart rate and rhythm, and the pulse to see if they are regular. He or she will also check for swelling in the legs or swelling in the feet, ...
Radiofreqeuncy Ablation therapy for arrhythmias caused by myocardial scar. Ablation Therapy for Arrhythmias and Cardiac Arrhythmias. Read about Ablation Therapy for Arrhythmias
Define Arrhythmias. Arrhythmias synonyms, Arrhythmias pronunciation, Arrhythmias translation, English dictionary definition of Arrhythmias. n. 1. An irregularity in the force or rhythm of the heartbeat: a fatal arrhythmia. 2. A condition characterized by such irregularities: treatments for...
Thank you for your interest in spreading the word on Circulation.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
Looking for atrial arrhythmia? Find out information about atrial arrhythmia. disturbance in the rate or rhythm of the heartbeat. Various arrhythmias can be symptoms of serious heart heart, muscular organ that pumps blood to all parts... Explanation of atrial arrhythmia
Our data suggest that global and regional arrhythmia substrates change throughout different phases of resuscitation, and that temperature alters substrates differently throughout the phases of resuscitation. At normal temperatures, LAD occlusion increases VEBs, global DOR, and cardiac alternans. TH decreases VEBs, yet increases global DOR, and similarly promotes cardiac alternans. During this phase, temperature does not alter the end result of increased incidence of VT/VF. After ROSC from VF arrest, but still during LAD occlusion, there remains an increase in VEBs and cardiac alternans in CT, whereas global DOR returns to baseline. TH reduces VEBs, the increase in global DOR is no longer seen, and cardiac alternans is similarly increased. Again, the incidence of VT/VF is similarly increased in CT and TH. During LAD reperfusion, the incidence of VEBs and alternans in the CT group is greater than baseline, but global DOR returns to near baseline levels. TH markedly increases the magnitude of ...
Arrhythmia occurs when the hearts rhythm becomes disturbed or arrhythmic. The most common form of arrhythmia is a heart palpitation, known as sinus arrhythmia. More serious forms of heart arrhythmia include atrial fibrillation, ventricular tachycardia and ventricular fibrillation. Arrhythmia requires medical treatment; some rhythm disturbances are addressed through the use of medications, defibrillation, or a pacemaker. Natural options for heart support include fish oil, hawthorn, vitamin C and magnesium.
MedWorm- Cardiac Arrhythmia comments, Description: MedWorm.com provides a medical RSS filtering service. Thousands of medical RSS feeds are combined and output via different filters. This feed contains the latest news in Cardiac Arrhythmia, ID: 284341, By: Feedage Forager
12-lead electrocardiogram is a vital component of electrophysiology workup for symptomatic palpitations and organic cardiac arrhythmias including supraventricular and ventricular arrhythmias.
This rare disease is characterized by episodic weakness, cardiac arrhythmias, and dysmorphic features (short stature, scoliosis, clinodactyly, hypertelorism, small or prominent low-set ears, micrognathia, and broad forehead). The cardiac arrhythmias are potentially serious and life threatening. They include long QT, ventricular ectopy, bidirectional ventricular arrhythmias, and tachycardia. For many years, the classification of this disorder was uncertain because episodes of weakness are associated with elevated, normal, or reduced levels of potassium during an attack. In addition, the potassium levels differ among kindreds but are consistent within a family. Inheritance is autosomal dominant, with incomplete penetrance and variable expressivity. The disease is caused by mutations of the inwardly rectifying potassium channel (Kir 2.1) gene that heighten muscle cell excitability. The treatment is similar to that for other forms of periodic paralysis and must include cardiac monitoring. The ...
This course covers cardiac electrical activity and the interpretation of electrocardiograms. The student echocardiographer develops skill in recognizing normal sinus rhythm versus atypical cardiac rhythms. Students learn to interpret common cardiac dysrhythmias, including sinus, atrial, junctional, and ventricular, and integrate this skill into the daily practice of echocardiography. The students will know the stress echo lab procedures including monitoring the patient. Students will learn to perform auscultation of the heart and lungs. Prerequisite: Acceptance into program, completion of DUTEC 155.. View details for DUTEC 200 ...
This course covers cardiac electrical activity and the interpretation of electrocardiograms. The student echocardiographer develops skill in recognizing normal sinus rhythm versus atypical cardiac rhythms. Students learn to interpret common cardiac dysrhythmias, including sinus, atrial, junctional, and ventricular, and integrate this skill into the daily practice of echocardiography. The students will know the stress echo lab procedures including monitoring the patient. Students will learn to perform auscultation of the heart and lungs. Prerequisite: Acceptance into program, completion of DUTEC 155.. View details for DUTEC 200 ...
Thank you for your interest in spreading the word on Circulation Research.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
An arrhythmia is a change in the rhythm of your heartbeat. When the heart beats too fast, its called tachycardia. When it beats too slow, its called bradycardia. An arrhythmia can also mean that your heart beats irregularly (skips a beat or has an extra beat). At some time or another, most people have felt their heart race or skip a beat.. Minor arrhythmias may be caused by excessive alcohol use, smoking, caffeine, stress or exercise. They usually are not a cause for alarm. Arrhythmias that occur more often or cause symptoms may be more serious and need to be discussed with your doctor.. ...
Cardiac arrhythmia is any of a large and heterogeneous group of conditions in which there is abnormal electrical activity in the heart. The heart beat may be too fast or too slow, and may be regular or irregular. A heart beat that is too fast is called tachycardia and a heart beat that is too slow is called bradycardia. Although many arrhythmias are not life-threatening, some can cause cardiac arrest. ...
ARVC is a hereditary heart condition in which the heart muscle (particularly the right ventricle) is partly replaced by fatty tissue and connective tissue. Cardiac arrhythmias can occur as a result of the changes in the heart muscle. Severe arrhythmias can cause dizziness or even lead to fainting or an acute cardiac arrest (= sudden death). ARVC is a progressive disease that usually presents during the teenage years.. Known mutations in desmosomal proteins ...
Learn more about Other Treatments for Arrhythmias (Heart Rhythm Disturbances) at Reston Hospital Center Main Page Types of Arrhythmias ...
Learn more about Type of Arrhythmias (Heart Rhythm Disturbances) at Portsmouth Regional Hospital Main Page Types of Arrhythmias Cause ...
Learn more about Conditions InDepth: Arrhythmias (Heart Rhythm Disturbances) at Doctors Hospital of Augusta Main Page Types of Arrhythmias ...
Learn more about Conditions InDepth: Arrhythmias (Heart Rhythm Disturbances) at Portsmouth Regional Hospital Main Page Types of Arrhythmias ...
Thanks to everyone who joined us Tuesday, February 24 for the live online chat entitled "Irregular Heart Beat: Is it normal?," hosted by Emory Arrhythmia Center physician Michael Hoskins, MD.. Because arrhythmias are common in young- and middle-aged adults, it is important to understand the symptoms. Some arrhythmias are relatively harmless, but others can be fatal if not treated. Dr. Hoskins provided answers to questions about the diagnosis and treatment of heart rhythm disorders, as well as tips of how to deal with an episode of irregular heart beats. Check out the conversation by viewing the chat transcript! Here are just a few highlights from the chat:. Question: I have observed that during some of these episodes my blood pressure is really low and it has been recognized that sometimes my oxygen level is low during the night. could this be causing my arrhythmias? I do have trouble breathing through a deviated nostril.. ...
Learn more about Conditions InDepth: Arrhythmias (Heart Rhythm Disturbances) at St. Davids HealthCare Main Page Types of Arrhythmias ...
Learn more about Type of Arrhythmias (Heart Rhythm Disturbances) at Coliseum Health System Main Page Types of Arrhythmias Cause ...
ABSTRACT: Patients with severe heart failure are at high risk of sudden cardiac death. In the majority of these patients, sudden cardiac death is thought to be due to ventricular tachyarrhythmias. Alterations of the electric properties of single myocytes in heart failure may favor the occurrence of ventricular arrhythmias in these patients by inducing early or delayed afterdepolarizations. Mathematical models of the cellular action potential and its underlying ionic currents could help to elucidate possible arrhythmogenic mechanisms on a cellular level. In the present study, selected ionic currents based on human data are incorporated into a model of the ventricular action potential for the purpose of studying the cellular electrophysiological consequences of heart failure. Ionic currents that are not yet sufficiently characterized in human ventricular myocytes are adopted from the action potential model developed by Luo and Rudy (LR model). The main results obtained from this model are as ...
KCNQ1 has been associated with Long QT Syndrome (LQTS), a life-threatening cardiac arrhythmia syndrome and leading cause of sudden death.
超聲心動圖經常用於評估心律不整,儘管它不記錄心臟的電流活動。超聲檢查探討心臟肌肉和心臟瓣膜的功能;如有異常,嚴重及有危險性的心律不整的機率就高得多。. Electrophysiology study (EPS) is used to assess serious arrhythmias. It is an invasive procedure that involves the passing of thin flexible electrodes through the groin veins and arteries to the heart, in order to record the hearts electrical signals. The wires can also stimulate and trigger an arrhythmia, in order to make the correct diagnosis. Catheter radiofrequency ablation may be performed during EPS, if it has been determined that the patients specific arrhythmia can be treated by delivering a special energy through the ablation catheter and destroying small areas of heart tissue responsible for the arrhythmia ...
Cardiologists and electrophysiologists face constantly evolving techniques and tools for diagnosing and treating patients with arrhythmia. Rapid change and new research make it difficult to ensure that electrophysiology diagnosis and treatment are consistent with the most current guidelines. Primary care physicians encounter patients with arrhythmia symptoms, heart failure, and syncope and must determine if patients are at risk of life-threatening arrhythmias or may otherwise benefit from referral to cardiologists or electrophysiologists. A lack of familiarity with current clinical guidelines regarding ICD implantation exists. There is a need to improve knowledge and competence among primary care physicians and cardiologists as it relates to current diagnosis and treatment guidelines for arrhythmia patients. ...
What is an arrhythmia? The American Heart Association has information about Atrial Fibrillation, quivering heart, Bradycardia, slow heart rate, Premature contraction, Tachycardia, fast beat, Ventricular Fibrillation, fluttering heart, Rhythm Disorders, treatment of arrhythmia, symptoms of arrhythmia, diagnosis of arrhythmia, monitoring the heart, and much more.
This subject is designed to introduce and assist the Registered Nurse to develop knowledge and skills in the care of cardiac patients and their families. The focus is on patients with atherosclerotic heart disease, myocardial infarction and congestive heart failure, including diagnosis of these dysfunctions. The course also introduces students to basic cardiac dysrhythmias interpretations and the appropriate interventions. Current literature and medical research are incorporated to assure evidence based practice for students working in a cardiology environment. The students have the opportunity to apply their new knowledge to application exercises and case study analysis. ...
Cardiac Science (Bothell, WA) is making available the Microvolt T-Wave Alternans (MTWA) module for its Quinton Q-Stress cardiac stress test system. The opt
CVD are one of the leading causes of mortality worldwide [1]. Due to the increase in obesity and MetS, CVD mortality and morbidity are expected to increase even higher posing a huge risk to public health and health care systems around the globe [1]. CVD include cardiomyopathy, cardiac dysrhythmias, myocarditis, myocardial infarction, hypertension and atherosclerosis [2]. A number of risk factors have been identified to be associated with CVD such as hypertension, obesity, smoking, life style, hyperlipidaemia, Type 2 Diabetes (T2D) and MetS [2]. MetS is a cluster of metabolic risk factors that has been shown to cause a two fold increase in cardiovascular outcomes and a 1.5 fold increase in all-cause mortality [3-5]. Central obesity, dyslipidemia, elevated blood pressure; elevated fasting glucose and insulin resistance are the most pivotal components of MetS [6]. MetS is also characterized by a chronic low grade inflammation state which can explain the increased CVD and T2D risk [7]. MetS is also ...
Cardiac Anesthesia ResearchThe Division of Cardiac Anesthesia is dedicated to defining advances in the perioperative assessment and management of cardiothoracic surgical patients. Current studies reflect a strong interest in echocardiographic technology and techniques, clotting dysfunction and therapy, cerebral oxygenation during cardiopulmonary bypass, and postoperative cardiac dysrhythmias.FacultyJune Chan, MDNatalia Ivascu, MDNikhil Kumar, MDJames Osorio, MDLisa Rong, MD
Levitra dapoxetine and 6. Debate whether or not widely used AEDs. Meperidine cause opioid withdrawal may also improve cardiac dysrhythmias. Bronchitis 3. Differentiate between adverse effects include headaches, Neurologic symptoms occur rap- When opioids are given.
Results VEQSI max was significantly longer in patients with a history of prior serious ventricular arrhythmia (214±20 ms and 172±21 ms respectively; p,0.001). Multivariate analysis established VEQSI max as an independent marker for previous life threatening events (OR 1.11; 95% CI 1.07 to 1.16; p,0.001). VEQSI max ,195 ms had 86% sensitivity and specificity for distinguishing patients who had suffered significant ventricular arrhythmia (LR 6.39; accuracy 0.86; p,0.001).. ...
Background-Electrocardiographic QRS duration, a measure of cardiac intraventricular conduction, varies ~2-fold in individuals without cardiac disease. Slow conduction may promote reentrant arrhythmias. Methods and Results-We performed a genome-wide association study (GWAS) to identify genomic markers of QRS duration in 5,272 individuals without cardiac disease selected from electronic medical record (EMR) algorithms at five sites in the Electronic Medical Records and Genomics (eMERGE) network. The most significant loci were evaluated within the CHARGE consortium QRS GWAS meta-analysis. Twenty-three single nucleotide polymorphisms in 5 loci, previously described by CHARGE, were replicated in the eMERGE samples; 18 SNPs were in the chromosome 3 SCN5A and SCN10A loci, where the most significant SNPs were rs1805126 in SCN5A with p=1.2x10-8 (eMERGE) and p=2.5x10-20 (CHARGE) and rs6795970 in SCN10A with p=6x10-6 (eMERGE) and p=5x10-27 (CHARGE). The other loci were in NFIA, near CDKN1A, and near ...
Learn more about Cardiac Arrhythmia at Reston Hospital Center Uses None Other Proposed Natural Treatments Acupuncture ...
Learn more about Cardiac Arrhythmia at Blake Medical Center Uses None Other Proposed Natural Treatments Acupuncture ...
The Diploma of Advanced Studies in Cardiac Arrhythmia Management trains future leaders in arrhythmology to deliver state-of-the-art cardiovascular services in the next decade and beyond. DAS-CAM brings together renowned experts, who will cover not only clinical cardiac electrophysiology and device technology, but also the leadership, biostatistics and health economics perspectives. The programme will empower electrophysiologists to fulfil leadership roles as well as regulatory and managerial positions in their hospitals, universities, and other work environments ...
Dr. El-Sherif is an internationally recognized expert in the field of basic and clinical cardiac electrophysiology. He has published over 450 peer reviewed papers, reviews, and book chapters and has authored and co-authored eight books. He is a member of the editorial board of several national and international journals and served on the National Institutes of Health, American Heart Association, and Veterans Affairs Central Office research study groups. His research has been consistently supported by federal and non-federal grants for the last 34 years and has dealt with the link between molecular biology, ion channel physiology, cellular electrophysiology and clinical presentations of cardiac arrhythmias. Dr El-Sherif has made several seminal contributions to understanding electrophysiological mechanisms of cardiac arrhythmias in general and in myocardial ischemia/infarction in particular. His early studies on the canine post-infarction model resulted in the description of the figure-of-eight ...
Dr. El-Sherif is an internationally recognized expert in the field of basic and clinical cardiac electrophysiology. He has published over 450 peer reviewed papers, reviews, and book chapters and has authored and co-authored eight books. He is a member of the editorial board of several national and international journals and served on the National Institutes of Health, American Heart Association, and Veterans Affairs Central Office research study groups. His research has been consistently supported by federal and non-federal grants for the last 34 years and has dealt with the link between molecular biology, ion channel physiology, cellular electrophysiology and clinical presentations of cardiac arrhythmias. Dr El-Sherif has made several seminal contributions to understanding electrophysiological mechanisms of cardiac arrhythmias in general and in myocardial ischemia/infarction in particular. His early studies on the canine post-infarction model resulted in the description of the figure-of-eight ...
The Cardiac Arrhythmia Service is a group of health professionals dedicated to the diagnosis, assessment, management and education of patients who either have or are at risk of developing heart rhythm disorders.
We use cookies to ensure that we give you the best experience on our website. If you click Continue we will assume that you are happy to receive all cookies and you will not see this message again. Click Find out more for information on how to change your cookie settings ...
Cardiac arrhythmias are one of the most frequent causes of death worldwide. A popular biological model used to study arrhythmogenesis is the cultured cardiac cell monolayer, which provides a good trade-off between physiological relevance and experimental access. Excitation wave patterns are imaged using high-bandwidth detectors, producing large data sets that are typically analyzed manually. To make such analysis less time consuming and less subjective, we have designed and implemented a toolkit for segmentation and tracking of cardiac waves in optical mapping recordings. The toolkit is optimized for high-resolution detectors to accommodate the growing availability of inexpensive high-resolution detectors for life science imaging applications (e.g., scientific CMOS cameras). The software extracts key features of propagating waves, such as wavefront speed and entropy. The methods have been validated using synthetic data, and real-world examples are provided, showing a difference in conduction velocity
Feeling dizzy, a racing heartbeat, shortness of breath, chest pain may signal cardiac arrhythmia, an irregular heartbeat that requires urgent medical attention
At Fondazione Poliambulanza Hospital in Brescia, we treat cardiac arrhythmias with the most innovative technological devices. Read this page to find out more info about.
Cardiac arrhythmias are a major cause of morbidity and mortality, particularly in the elderly. With the rapidly changing population demographics, and increasing prevalence of cardiovascular disease,...
Lima notes that a patient with an ejection fraction of 60 percent has normal pumping ability, but anything less than 30 percent for a period of nine months or longer is considered low and an immediate risk factor for arrhythmia. He adds that if a patient has an ejection fraction that is slightly above 30 percent, then an electrophysiology test is used to determine if a patient requires a defibrillator. In this test, a thin catheter is inserted into the heart to try to induce an arrhythmia, something that will fail if the heart is healthy and not at risk. However, if it happens once, it is known to be two to four times more likely to happen again, he says ...
The Kentucky Chapter of the American College of Cardiology (KYACC) is dedicated to contributing to the prevention of cardiovascular disease and ensuring optimal quality of care for individuals with such diseases.
Cardiac arrythmias, or cardiac rhythm disturbances, are usually diagnosed based on the persons symptoms, medical history, risk factors, a physical ex
An association between cardiac arrhythmias and ethanol use has been observed for some time. The sympathetic nervous system presumably plays an important role in the manifestation of cardiovascular...
VT vs SVT Cardiac arrhythmias are one of the most dangerous things that can happen in a person who has and has not had any history of heart disease. This
Anti-arrhythmic drugs are a mainstay in the management of symptoms related to arrhythmias, and are adjuncts in prevention and treatment of life-threatening ventricular arrhythmias. However, they also have the potential for pro-arrhythmia and thus the prediction of arrhythmia predisposition and drug response are critical issues. Clinical trials are the latter stages in the safety testing and efficacy process prior to market release, and as such serve as a critical safeguard. In this review, we look at some of the lessons to be learned from approaches to arrhythmia prediction in patients, clinical trials of drugs used in the treatment of arrhythmias, and the implications for the design of pre-clinical safety pharmacology testing ...
Spontaneous reentrant ventricular arrhythmias were observed in 4 of 9 AP-A experiments (44%) after abrupt shortening of CL associated with QT/T alternans and the increase in Mid-Epi dispersion of ARI (Table 2⇓). Ventricular arrhythmias ranged from 1 or 2 reentrant beats in 1 experiment to sustained polymorphic VT requiring cardioversion in the 3 other experiments. Reentrant arrhythmias were consistently initiated only by the paced beats that followed the ones associated with greater Mid-Epi dispersion of ARI (P3, P5, and P7). This is illustrated in Figure 9⇑, obtained from the same experiment in which recordings were obtained before and after AP-A. The figure shows surface ECG leads during abrupt shortening of a basic CL of 1000 to 400 ms. In Figure 9A⇑, a single reentrant beat (R) followed P3; in Figure 9B⇑, a single reentrant beat followed P5; and in Figure 9C⇑, 2⇑ reentrant beats followed P7. Figure 10⇓ shows recordings from the same needle in the left ventricular free wall ...
An arrhythmia is a disorder of the heart rate (pulse) or heart rhythm. The heart can beat too fast (tachycardia), too slow (bradycardia), or irregularly. An arrhythmia can be harmless, a sign of other heart problems, or an immediate danger to your health.
Arrhythmia can manifest when the heart beats very fast (tachycardia) or very slowly (bradycardia). Arrhythmia is the result of interference with the electrical pathways that produce the hearts rhythmic muscular contractions.
Heart arrhythmias can be treated in different ways depending on the type of abnormal rhythm. Learn more about the most common treatments for arrhythmia.
The present invention relates to methods for predicting the risk for ventricular arrhythmias in a subject who has previously suffered a myocardial infarction (MI) or suffers from a primary cardiomyop
Related Media: Understanding Atrial FibrillationArrhythmias That Start in the AtriaSinus Arrhythmia -Cyclic changes in the heart rate during...
Background: The animal models (in vitro or in vivo) provide an excel-lent tool to study heart diseases, among them the arrhythmia remains one of the most active research subjects. It can be induced or treated by drugs, electrical stimulation, hypothermia etc. Problems: However, the inducing or treating effects in cardiac culture often happened long after the initial applications or in some relatively short time windows. So, it is necessary to capture and classify rapidly the signal change. Human-assisted monitoring is time-consuming and less efficient. An automatic classification method for real-time use would be useful and necessary. Methods: Since electrocardiological signals are features by repetitive or similar patterns reflecting the intrinsic information about the pa-tient (or culture), analyzing these patterns could help not only to monitor the statuss change but also to evaluate/explore the physiol-ogic control mechanisms. Methods based on complexity analysis are of considerable interest
Cardiology consultants can find the latest news & information about cardiovascular disease & cardiology conferences by going to Radcliffe cardiologys website.
abstract = "Connexin 43 (Cx43), a gap junction protein seemingly fit to support cardiac impulse propagation and synchronic contraction, is phosphorylated in normoxia by casein kinase 1 (CK1). However, during cardiac ischemia or pressure overload hypertrophy, this phosphorylation fades, Cx43 abundance decreases at intercalated disks and increases at myocytes lateral borders, and the risk of arrhythmia rises. Studies in wild-type and transgenic mice indicate that enhanced CK1-phosphorylation of Cx43 protects from arrhythmia, while dephosphorylation precedes arrhythmia vulnerability. The mechanistic bases of these Cx43 (de)phosphoform-linked cardiac phenotypes are unknown. We used patch-clamp and dye injection techniques to study the channel function (gating, permeability) of Cx43 mutants wherein CK1-targeted serines were replaced by aspartate (Cx43-CK1-D) or alanine (Cx43-CK1-A) to emulate phosphorylation and dephosphorylation, respectively. Cx43-CK1-D, but not Cx43-CK1-A, displayed high ...
Electrophysiological study. Through this method, the location airtmia and the cause can be determined by using the technique of mapping the spread of electrical impulses in the heart. In mapping, the doctor will insert a catheter equipped with electrodes to some blood vessels in the heart. In addition to seeing the location and cause arrhythmias, electrophysiology studies can also be used similar to the pressure test method. The trick is to stimulate the heart to contract at a level that can trigger rate changes by using the electrode. ...
Cardiac Mechano-Electric Coupling and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction.
When your heart skips, you may feel dizzy or anxious. Although an irregular heartbeat is often harmless, it should be treated with care. According to research or other evidence, the following self-care steps may be helpful. Cut the caffeineReduce the frequency of some arrhythmias by cutting back on coffee and other...
Cardiac Mechano-Electric Feedback and Arrhythmias offers a thoroughly reviewed compendium written by leading experts in the field on the mechanism and consequences of cardiac mechano-electrical coupling. Its coverage ranges from stretch-activated ion channels to mechanically induced arrhythmias and mechanical interventions for heart rhythm correction.
Safety of beta cells from autoimmune destruction potentially cures type 1 diabetes mellitus (T1D). normalize the early onset of hyperglycemia. When drug-induced diabetic mice received LY450108 MHC-matched allo-islets with or LY450108 without pretreatment of the PDL1-CTLA4Ig-expressing vector PDL1-CTLA4Ig-expressing islets were protected from rejection for at least 120 days. Similarly transplantation of PDL1-CTLA4Ig-expressing MHC-matched islets into … Continue reading Safety of beta cells from autoimmune destruction potentially cures type 1. ...
Inspiration: Developments in high-resolution microscopy possess lately made possible the evaluation of gene reflection in the level of individual cells. permitting high-throughput conversion of unstructured image data into well-structured gene manifestation furniture appropriate for computational analysis. Earlier methods for single-cell gene manifestation analysis in model organisms possess mainly relied on time-series info and region guns … Continue reading Inspiration: Developments in high-resolution microscopy possess lately made possible the evaluation. ...
A device which monitors electrocardiac activity for providing direct and discrete output readings which simply and positively identify specific cardiac activity patterns. Samples are taken over predetermined time intervals during which the total number of cycles of the entire electrocardiac signal occurring during the time interval undergoes slope analysis for the purpose of providing in-line indices of the various cardiac arrhythmias. Mathematical manipulation of the electrocardiac signals (also referred to as EKG signals) are performed by analog circuit means to yield a direct output reading which, by providing an appropriate scale or by providing a chart usable in conjunction with the output meter, positively and directly provides an indication of the various cardiac arrhythmias.
A new cardiac monitoring device from Preventice (Minneapolis, MN) has been cleared by the FDA to help physicians keep an eye on arrhythmia patients as they
The steady lup-dup, lub-dup regularity of our hearts pumping beat is reassuring, and we dont mind it speeding up for exercise or slowing down for sleep, as long as its rhythm remains steady. Any glitch in that rhythmic throb, whether too slow or too fast, is called an arrhythmia. In either case, you can feel dizzy or lightheaded because not enough blood is getting to the brain when the heart rhythm is off-kilter. To assess and correct an arrhythmia requires a medical professional. Many times it...
An arrhythmia is an abnormal rhythm of the heart. In an arrhythmia, abnormal electrical signals through the heart muscle may cause the heart to beat too fast (tachycardia), too slow (bradycardia), or irregularly.
Your doctor will help you determine whether you need arrhythmia treatment or if he or she wants to take a lets watch approach. Arrhythmia treatment can help control your heart rate and therefore reduce some risk factors for heart disease and stroke.
Your doctor will help you determine whether you need arrhythmia treatment or if he or she wants to take a lets watch approach. Arrhythmia treatment can help control your heart rate and therefore reduce some risk factors for heart disease and stroke.
Your doctor will help you determine whether you need arrhythmia treatment or if he or she wants to take a lets watch approach. Arrhythmia treatment can help control your heart rate and therefore reduce some risk factors for heart disease and stroke.
Your doctor will help you determine whether you need arrhythmia treatment or if he or she wants to take a lets watch approach. Arrhythmia treatment can help control your heart rate and therefore reduce some risk factors for heart disease and stroke.
The foveal word n was either five medicine equivalent to cymbalta six letters long and the parafoveal tг was always four letters long. Additionally, the refinement of arrhythmia detection has allowed these devices to be automated, detecting dangerous cardiac events and firing the defibrillator without the need for operator intervention.
A system and method for treating an arrhythmia of the heart, involves delivery of anti-tachy pacing (ATP) pulses to the heart, possibly followed by the delivery of a high-voltage shock. ATP delivery is controlled such that the time delivery of any high-voltage shock is not affected by the prior delivery of the ATP pulses. System control may be accomplished using one or more programmable parameters, which may include a user-specified shock energy.
Mortality owing to iatrogenic hypoglycemia represents a major concern for insulin-treated diabetic patients and their families. Determining the mechanisms by which hypoglycemia causes sudden death is critically important in order to find treatment strategies that could protect at-risk patients. Based on ECG anomalies reported during moderate hypoglycemia (26), it has been speculated that the "dead in bed syndrome" may be mediated by hypoglycemia-induced fatal arrhythmias. In the current study, it is shown for the first time that fatal cardiac arrhythmias occur during severe hypoglycemia and can be reduced by ICV glucose infusion and prevented by β-adrenergic blockade, indicating that brain neuroglycopenia and the striking sympathoadrenal response mediate fatal cardiac arrhythmias during severe hypoglycemia (Fig. 7A).. In these experiments, diabetes per se nearly doubled the mortality risk associated with severe hypoglycemia. Uncontrolled diabetes is hypothesized to increase risk of fatal ...
Cardiovascular disease in general, and cardiac arrhythmias specifically, is common in great apes. However, the clinical significance of arrhythmias detected on short-duration electrocardiograms is often unclear. Here we describe the use of an implantable loop recorder to evaluate cardiac rhythms in 4 unanesthetized adult chimpanzees (Pan troglodytes), 1 with a history of possible syncope and 3 with the diagnosis of multiform ventricular ectopy (ventricular premature complexes) and cardiomyopathy. The clinical significance of ventricular ectopy was defined further by using the implantable loop recorder. Arrhythmia was ruled out as a cause of collapse in the chimpanzee that presented with possible syncope because the implantable loop recorder demonstrated normal sinus rhythm during a so-called syncopal event. This description is the first report of the use of an implantable loop recorder to diagnose cardiac arrhythmias in an unanesthetized great ape species ...
Neither Encainide nor Flecainide should be used in the treatment of patients with asymptomatic or minimally symptomatic ventricular arrhythmia after myocardial infarction, even though these drugs may be effective initially in suppressing ventricular arrhythmia. The suppression of asymptomatic or mildly symptomatic ventricular arrhythmias after myocardial infarction does not improve survival and can increase mortality. Treatment strategies designed solely to suppress these arrhythmias should no longer be followed.. ...
article{ceee0ce3-7cdb-426b-8c17-2f62ad33a172, abstract = {,p,AIMS: To evaluate the usefulness of the signed value of monophasic action potential duration difference in analysing the cause of dispersion of ventricular repolarization.,/p,,p,METHODS AND RESULTS: Monophasic action potentials were simultaneously recorded from the right ventricular apex and outflow tract during programmed stimulation in 36 patients with ventricular arrhythmias. The time difference between the ends of repolarization on the two monophasic action potentials was used as a measure of the dispersion of ventricular repolarization, and the signed value of the monophasic action potential duration difference was used to specify the contributions of the activation time difference and the monophasic action potential duration difference to the dispersion of ventricular repolarization. During right ventricular pacing, single and double programmed stimulation and at the induction of ventricular arrhythmias, the dispersion of ...
TY - JOUR. T1 - Diuretic-induced hypokalaemia and ventricular arrhythmias. AU - Holland, O. B.. PY - 1984. Y1 - 1984. N2 - In the past, adverse cardiac effect of potassium depletion in non-digitalised patients and in patients without cardiac disease were considered to be minimal. However, several studies have now demonstrated a significant incidence of ventricular ectopic activity in diuretic-treated patients, particularly in those who became hypokalaemic. Potassium repletion with potassium-sparing diuretics or with potassium chloride supplementation has generally demonstrated a beneficial therapeutic effect in reducing ventricular ectopic activity. However, occasional patients may have persistent ventricular ectopic activity after diuretic therapy which may result from focal myocardial lesions associated with potassium depletion. In addition, factors other than potassium depletion appear to initiate or magnify diuretic-induced ventricular ectopic activity. Thus, to avoid these adverse cardiac ...
Looking for online definition of premature ventricular contraction in the Medical Dictionary? premature ventricular contraction explanation free. What is premature ventricular contraction? Meaning of premature ventricular contraction medical term. What does premature ventricular contraction mean?
Pulmonary artery catheterization is associated with numerous complications, including serious arrhythmias. We report a case where ventricular tachycardia occurred repeatedly during attempted pulmonary artery catheterization, precluding successful catheterization. Transesophageal echocardiography was used to image the tricuspid valve and right ventricle and revealed a Sinus of Valsalva aneurysm protruding significantly into the right ventricle and obstructing advancement of the pulmonary artery catheter. Our case reveals another identifiable cause of serious arrhythmia during pulmonary artery catheterization and highlights how transesophageal echocardiography can be useful in unanticipated ways during cardiac anesthesia and surgery. ...
Definition, Etiology, PathogenesisTop. Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a genetic disease involving mainly the right ventricle. It is caused by the gradual replacement of myocardial fibers by fatty and fibrous tissue, particularly in the right ventricular inflow, outflow, and apex, which leads to a propensity to ventricular arrhythmias and sudden cardiac death. Morphologic and functional changes can also occur in the left ventricle (LV), producing a phenotype similar to dilated cardiomyopathy. Causes: Gene mutations, which are usually autosomal dominant.. Clinical Features and Natural HistoryTop. 1. History: ARVC usually presents in young adult men. The first symptom is a brief loss of consciousness caused by ventricular arrhythmia. Sudden cardiac death may occur.. 2. Risk factors of sudden cardiac death include a young age, history of syncope, cardiac arrest or hemodynamically significant ventricular tachycardia, LV involvement, significant right ventricular damage, ...
INTRODUCTION: Loss-of-function mutations in the SCN5A gene encoding the cardiac sodium channel are responsible for Brugada syndrome (BS) and also for progressive cardiac conduction disease (inherited Lenègre disease). In an attempt to clarify the frontier between these two entities, we have characterized cardiac conduction defect and its evolution with aging in a cohort of 78 patients carrying a SCN5A mutation linked to Brugada syndrome. METHODS AND RESULTS: Families were included in the study if a SCN5A mutation was identified in a BS proband and if at least two family members were mutation carriers. Sixteen families met the study criteria, representing 78 carriers. Resting ECG showed a spontaneous BS ECG pattern in 28 of 78 (36%) gene carriers. Intraventricular conduction anomalies were identified in 59 of 78 gene carriers including complete (17) or incomplete (24) right bundle branch block, right bundle branch block plus hemiblock (6), left bundle branch block (1), hemiblock (1), and parietal block

Cardiac arrhythmia - ScholarpediaCardiac arrhythmia - Scholarpedia

Overview of arrhythmias. Abnormal cardiac rhythms are called cardiac arrhythmias. Cardiac arrhythmias are associated with ... abnormal propagation of a wave of cardiac excitation, or some combination of the two. Cardiac arrhythmias can manifest ... "Cardiac arrhythmia" by Flavio H Fenton, Elizabeth M. Cherry and Leon Glass is licensed under a Creative Commons Attribution- ... Cardiac arrhythmia is the condition in which the hearts normal rhythm is disrupted. In this article, we describe the hearts ...
more infohttp://www.scholarpedia.org/article/Cardiac_arrhythmia

What is cardiac arrhythmiaWhat is cardiac arrhythmia

... * 1. This Article Has Been Brought to You for Free by WHAT IS www.freud-sigmund.com CARDIAC ... CARDIAC ARRHYTHMIAS TREATMENT IN TA... by integratedcardiac... 574 views * State of art mapping and imaging te... by Taiwan ... Anextra systole interrupts normal Atria arrhythmias originate in the atria:sequence of activation of cardiac - Ectopic atria - ... Ventricle can sinceoccur frequently we speak of arrhythmia. Arrhythmias compensate for this loss but long term exhaustion ...
more infohttps://www.slideshare.net/341987/what-is-cardiac-arrhythmia

Sex Differences in Cardiac Arrhythmias | SpringerLinkSex Differences in Cardiac Arrhythmias | SpringerLink

Cardiac arrhythmias comprise a heterogenous group of disorders ranging from benign premature heart beats to malignant sustained ... Cardiac arrhythmias comprise a heterogenous group of disorders ranging from benign premature heart beats to malignant sustained ... Ehdaie A., Chugh S.S. (2018) Sex Differences in Cardiac Arrhythmias. In: Mehta J., McSweeney J. (eds) Gender Differences in the ... This chapter will review sex differences in different cardiac arrhythmias with an emphasis on clinical evaluation, treatment, ...
more infohttps://link.springer.com/chapter/10.1007%2F978-3-319-71135-5_14

Clinical Aspects of Cardiac Arrhythmias | SpringerLinkClinical Aspects of Cardiac Arrhythmias | SpringerLink

Clinical Aspects of Cardiac Arrhythmias. Recent years have seen the publication of many textbooks on cardiac arrhythmias, some ... Clinical Aspects of Cardiac Arrhythmias. Recent years have seen the publication of many textbooks on cardiac arrhythmias, some ... metabolic aspects of cardiac arrhythmias and reperfusion arrhythmias, which are not directly or exclusively clinical. However, ... Although the epidemiology of clinical arrhythmias is difficult to dis- cover, it is widely appreciated that arrhythmias are ...
more infohttps://link.springer.com/book/10.1007%2F978-94-009-1289-2

Catheter ablation for cardiac arrhythmias | The BMJCatheter ablation for cardiac arrhythmias | The BMJ

Catheter ablation for cardiac arrhythmias. BMJ 2001; 322 doi: https://doi.org/10.1136/bmj.322.7286.613/a (Published 10 March ...
more infohttp://www.bmj.com/content/322/7286/613.2

HUS - 
        Cardiac arrhythmias
	HUS - Cardiac arrhythmias

Congenital arrhythmias may present as arrhythmic sensations, loss of consciousness, cardiac arrest, or sudden death. However, ... Congenital arrhythmias. Congenital arrhythmias usually cause serious arrhythmic attacks. In other respects, your heart might be ... People with congenital arrhythmias may be asymptomatic or the symptoms may not have been diagnosed. Finding carriers is ... If extrasystoles are frequent, they may disturb circulation and cardiac function and must be treated. On rare occasions, ...
more infohttps://www.hus.fi/en/medical-care/medical-services/heart-diseases/Cardiology/About_heart_diseases/Cardiac_arrhythmias/Pages/default.aspx

Management of Cardiac Arrhythmias | Gan-Xin Yan | SpringerManagement of Cardiac Arrhythmias | Gan-Xin Yan | Springer

The first edition of Management of Cardiac Arrhythmias, published over ten years ... Few areas of medicine have evolved as rapidly as cardiac electrophysiology. What were only a short time ago seen to be lethal ... "This is a fine book on cardiac arrhythmias and provides a bridge from clinical cardiology and arrhythmia management to ... Management of Cardiac Arrhythmias. Editors: Yan, Gan-Xin, Kowey, Peter R. (Eds.) ...
more infohttps://www.springer.com/us/book/9781607611608

Acute emotional stress and cardiac arrhythmias.  - PubMed - NCBIAcute emotional stress and cardiac arrhythmias. - PubMed - NCBI

Acute emotional stress and cardiac arrhythmias.. Ziegelstein RC1.. Author information. 1. Department of Medicine, Johns Hopkins ... Patients with ischemic heart disease who survive an episode of sudden cardiac death in the setting of acute emotional stress ... areas of inhomogeneous repolarization that create electrical instability and facilitate the development of cardiac arrhythmias ... Acute emotional stress can produce left ventricular contractile dysfunction, myocardial ischemia, or disturbances of cardiac ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/17635893?dopt=Abstract

Treatment of cardiac arrhythmias with phenytoin | The BMJTreatment of cardiac arrhythmias with phenytoin | The BMJ

Treatment of cardiac arrhythmias with phenytoin Br Med J 1969; 4 :270 ... Phenytoin was given intravenously in 37 patients with cardiac arrhythmias-21 had acute myocardial infarction and 16 had other ... Treatment of cardiac arrhythmias with phenytoin. Br Med J 1969; 4 doi: https://doi.org/10.1136/bmj.4.5678.270 (Published 01 ... Digitalis played no part in producing any of the arrhythmias. Phenytoin was used orally for suppressing and preventing abnormal ...
more infohttp://www.bmj.com/content/4/5678/270

Cardiac Arrhythmias | GreenMedInfo | Disease | Natural MedicineCardiac Arrhythmias | GreenMedInfo | Disease | Natural Medicine

This topic contains 65 study abstracts on Cardiac Arrhythmias indicating that the following substances may be helpful: Omega-3 ... Diseases : Arrhythmias: Cardiac, Cardiac Mortality , Coronary Artery Disease, High Homocysteine, Myocardial Infarction ... Diseases : Atrial Arrhythmias, Atrial Fibrillation, Atrial Flutter, Cardiac Mortality Anti Therapeutic Actions : ... Diseases : Cardiac Arrhythmias, Heart Failure, Organ Transplantation: Liver, Pulmonary Edema. Additional Keywords : Diseases ...
more infohttp://www.greenmedinfo.com/disease/cardiac-arrhythmias

High Performance Computing to Study Cardiac ArrhythmiasHigh Performance Computing to Study Cardiac Arrhythmias

... July 30, 2018. July 30, 2018 - A team of researchers lead by Mark ... This work took place at IHU Liryc, a research institute dedicated to cardiac arrhythmias, with one of the largest clinical ... physiologists and other specialists to cover all the different aspects of cardiac arrhythmias. Thanks to this collaboration and ... Cardiac diseases are among the biggest causes of death in Europe, and almost half of these deaths are linked to racing heart ...
more infohttps://www.hpcwire.com/off-the-wire/high-performance-computing-to-study-cardiac-arrhythmias/

Khat Chewing Induces Cardiac ArrhythmiaKhat Chewing Induces Cardiac Arrhythmia

Conclusions: 1) Serious arrhythmias occur in both cardiac and non-cardiac individuals during khat chewing days although they ... 30 were cardiac patients and the other 30 were non-cardiac individuals. All 60 individuals underwent 24 hours holter monitoring ... Results: The non-sustained VT was found on 7 (23.3%) of the 30 cardiac patients on a khat-chewing day compared to 2 patients ( ... Aims: To study the effects of khat chewing on cardiac rhythm. Methods: We selected sixty khat-chewing Yemeni individuals and ...
more infohttps://www.scirp.org/journal/paperinformation.aspx?paperid=69544

Cardiac Arrhythmias and Marijuana - Salem-News.ComCardiac Arrhythmias and Marijuana - Salem-News.Com

Cardiac Arrhythmias and Marijuana. Dr. Phillip Leveque Salem-News.com No arrhythmias with 6,000 patients. ... In no case did we ever find a cardiac arrhythmia such Auricular flutter or fibrillation and no ventricular arrhythmias except ... Whether anyone was able to do this I do not know but Bretylium was one of the Cardiac arrhythmia drugs recommended by the ... Bretylium also works in humans for both auricular and ventricular arrhythmias.. I am no longer surprised when someone finds a ...
more infohttp://www.salem-news.com/articles/april052008/doc_hearts_4-5-08.php

Cardiac Arrhythmia - ScholarpediaCardiac Arrhythmia - Scholarpedia

Overview of arrhythmias. Abnormal cardiac rhythms are called cardiac arrhythmias. Cardiac arrhythmias are associated with ... abnormal propagation of a wave of cardiac excitation, or some combination of the two. Cardiac arrhythmias can manifest ... "Cardiac Arrhythmia" by Flavio H Fenton, Elizabeth M. Cherry and Leon Glass is licensed under a Creative Commons Attribution- ... Cardiac arrhythmia is the condition in which the hearts normal rhythm is disrupted. In this article, we describe the hearts ...
more infohttp://www.scholarpedia.org/article/Defibrillation

PatientsLikeMe | Irregular heartbeat (cardiac arrhythmia) - PatientsLikeMePatientsLikeMe | Irregular heartbeat (cardiac arrhythmia) - PatientsLikeMe

... cardiac arrhythmia). Join the community to connect with others like you and learn about their real-world experiences. ...
more infohttps://www.patientslikeme.com/symptoms/show/11241-irregular-heartbeat-cardiac-arrhythmia

Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias TutorialBlaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial

You just viewed Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial, please rate this material. Dont show this ... Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial. This website allows visitors to see and hear extensive ... Discussion for Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial Log in to participate in the discussions or ... Select this link to add material Blaufuss Multimedia Heart Sounds and Cardiac Arrhythmias Tutorial to Bookmark material or ...
more infohttps://www.merlot.org/merlot/viewMaterial.htm?id=82497

Patent US5904709 - Microwave treatment for cardiac arrhythmias - Google PatentsPatent US5904709 - Microwave treatment for cardiac arrhythmias - Google Patents

... depths sufficient for thermally ablating arrhythmogenic cardiac tissue to treat ventricular tachycardia and other arrhythmias ... Due to the potential seriousness of cardiac arrhythmias and the limited number of patients that open heart surgery can help, ... An additional significant problem of ventricular tachycardia, as compared with other types of cardiac arrhythmias, is that the ... Because of the potential seriousness of the problem of cardiac arrhythmias, numerous inventors have attempted to solve various ...
more infohttp://www.google.com/patents/US5904709?dq=6480844

Link between alcohol consumption and cardiac arrhythmias | EurekAlert! Science NewsLink between alcohol consumption and cardiac arrhythmias | EurekAlert! Science News

The research, which is published in the European Heart Journal, is important because it is thought that arrhythmias can, in ... that the more alcohol consumed the higher was the likelihood of developing abnormal heart rhythms called cardiac arrhythmias. ... the researchers found cardiac arrhythmias in 30.5% of the participants and 25.9% of these arrhythmias were sinus tachycardia, ... Link between alcohol consumption and cardiac arrhythmias. European Society of Cardiology. Journal. European Heart Journal. ...
more infohttps://www.eurekalert.org/pub_releases/2017-04/esoc-lba042417.php

Pharmacology of Cardiac Arrhythmias FlashcardsPharmacology of Cardiac Arrhythmias Flashcards

"triggered" arrhythmias. Definition. transient depolarization triggers extra cardiac beats, most often in cells overloaded with ... cardiac arrhythmias: bradycardia, blocks, tachycardia. *hypotension and decreased contractility (ganglionic blocking activity) ... used extensively for acute suppression of ventricular arrhythmias b/c it has little cardiac toxicity ... Arrhythmias often arise from:. Definition. *abnormalities in automaticity that give rise to abnormal sites of pacemaker ...
more infohttps://www.flashcardmachine.com/pharmacology-of-cardiacarrhythmias.html

Cardiac Arrhythmias - Basic to Complex | AllConferences.comCardiac Arrhythmias - Basic to Complex | AllConferences.com

Cardiac Arrhythmias - Basic to Complex. 2 day seminar at a 5 star venue with popular Australasian presenter Anne Evans-Murray ... Life threatening arrhythmias. - Ventricular tachycardia, Ventricular fibrillation, P.E.A./A.M.D.. • Cardiac drugs. - Adrenaline ... Miscellaneous Arrhythmias. • Bundle Branch Blocks. • Cardiac Axis shifts. • Pre excitation Syndrome. • Wolf-Parkinson-White ( ... Become one of the few who can easily and quickly analyse any cardiac arrhythmia by following Annes simple systematic approach. ...
more infohttp://www.allconferences.com/conferences/2005/20050720200559

JCI -
Long QT syndrome: from channels to cardiac arrhythmiasJCI - Long QT syndrome: from channels to cardiac arrhythmias

Long QT syndrome, a rare genetic disorder associated with life-threatening arrhythmias, has provided a wealth of information ... about fundamental mechanisms underlying human cardiac electrophysiology that has come about because of truly collaborative ...
more infohttps://www.jci.org/articles/view/25537/pdf

JCI -
Long QT syndrome: from channels to cardiac arrhythmiasJCI - Long QT syndrome: from channels to cardiac arrhythmias

Cardiac sodium channel mutations in patients with long QT syndrome, an inherited cardiac arrhythmia. Hum. Mol. Genet. 1995. 4: ... Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. Nature. 2003. 421:634-639. View this ... A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. Proc. Natl. Acad. Sci. U. S. A. 2004. 101:9137-9142. View ... Spectrum of HERG K channel dysfunction in an inherited cardiac arrhythmia. Proc. Natl. Acad. Sci. U. S. A. 1996. 93:2208-2212. ...
more infohttps://www.jci.org/articles/view/25537

Optical Mapping Of Cardiac Arrhythmias  - CogprintsOptical Mapping Of Cardiac Arrhythmias - Cogprints

Arora, Rishi and Das, Mithilesh K and Zipes, Douglas P and Wu, Jianyi (2003) Optical Mapping Of Cardiac Arrhythmias. [Journal ( ... Optical Mapping of Cardiac Excitation and Arrhythmias. Armonk, NY: Futura; 2001:61-78. ... Optical Mapping of Cardiac Excitation and Arrhythmias. Armonk, NY: Futura; 2001:97-112. ... Optical Mapping of Cardiac Excitation and Arrhythmias. Armonk, NY: Futura; 2001:113-135. ...
more infohttp://cogprints.org/4242/index.html

Gene Therapy in Cardiac Arrhythmias   - CogprintsGene Therapy in Cardiac Arrhythmias - Cogprints

Praveen, S.V and Francis, Johnson and Venugopal, K (2006) Gene Therapy in Cardiac Arrhythmias. [Journal (Paginated)] ... its application has evolved to vascular angiogenesis and cardiac arrhythmias. Gene based biological pacemakers using viral ... Arrhythmias in a failing heart are due to abnormal calcium cycling. Potential targets for genetic modulation include the ... Hobai IA, ORourke B. The potential of Na+/Ca2+ exchange blockers in the treatment of cardiac disease. Expert Opin Investig ...
more infohttp://cogprints.org/4805/

Relation of Electrolyte Disturbances to Cardiac Arrhythmias | CirculationRelation of Electrolyte Disturbances to Cardiac Arrhythmias | Circulation

Thank you for your interest in spreading the word on Circulation.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
more infohttp://circ.ahajournals.org/content/49/1/193.1
  • Patients with ischemic heart disease who survive an episode of sudden cardiac death in the setting of acute emotional stress should receive a beta-blocker. (nih.gov)
  • When asked to contribute to the series 'Current Status of Clinical Cardiology' we felt that the clinical aspects of cardiac arrhyth- mias should be emphasized, and that the text should be as comprehensive as possible within the limitations of a single volume in this series. (springer.com)
  • The modellers used nine million core hours on GENCI's supercomputers , including Turing, Occigen and Curie , and worked closely with cardiologists as well as with biologists, physiologists and other specialists to cover all the different aspects of cardiac arrhythmias. (hpcwire.com)
  • We welcome experts on this research topic to share their original research on cardiac ion channel trafficking from the basic science lab and the clinic, to submit solid review papers on the intricate aspects of cardiac ion channel trafficking and to bring forward hypotheses that provide new avenues in this fascinating field with extraordinary clinical implications. (frontiersin.org)
  • For example, magnesium is clearly able to prevent a drug-induced arrhythmia called torsade de pointes, but it does not appear to prevent atrial fibrillation. (peacehealth.org)
  • A controlled study found preliminary evidence that vitamin C may help prevent one of the types of arrhythmia (atrial fibrillation) that can follow coronary artery bypass grafting. (medicalcityhospital.com)
  • Those people taking 3.2 grams per day of magnesium chloride (equivalent to 384 mg per day of elemental magnesium) had between 23% and 52% fewer occurrences of specific types of arrhythmia during the six-week study, compared with those taking placebo. (peacehealth.org)
  • Anextra systole interrupts normal Atria arrhythmias originate in the atria:sequence of activation of cardiac - Ectopic atria - ectopic impulsesmuscle. (slideshare.net)
  • 18. Mazhari R, Nuss HB, Armoundas AA, Winslow RL, Marban E. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. (cogprints.org)
  • Moreover, in the next decade cardiac ion channel trafficking research has to transit from ectopic cell expression systems, via isolated adult cardiomyocytes and tissue explants into in vivo approaches. (frontiersin.org)
  • The rhythm of the heart is set by a small region of cardiac muscle cells in the right atrium called the sinoatrial (SA) node that acts as a spontaneous pacemaker, but is under the control of nerves and circulating hormones that affect the heart rate via a host of control circuits that maintain adequate blood pressure and oxygenation. (scholarpedia.org)
  • Gene therapy to develop a genetically engineered cardiac pacemaker. (cogprints.org)
  • Lateralization of cerebral activity during emotional stress may stimulate the heart asymmetrically and produce areas of inhomogeneous repolarization that create electrical instability and facilitate the development of cardiac arrhythmias. (nih.gov)
  • Taneja T, Mahnert BW, Passman R, Goldberger J, Kadish A. Effects of sex and age on electrocardiographic and cardiac electrophysiological properties in adults. (springer.com)
  • Furthermore, the field of cardiac ion channel trafficking is challenged to apply new concepts from basic cell biology that focus on the general structure and basic mechanisms of intracellular transport toward the level of individual ion channels. (frontiersin.org)
  • This mechanism is operated by around twenty different types of molecular "machine" in the external membrane of each cardiac cell. (hpcwire.com)
  • The QT interval prolongation may arise from either a decrease in repolarizing cardiac membrane currents or an increase in depolarizing cardiac currents late in the cardiac cycle. (jci.org)
  • The role of anchoring proteins in steering channel trafficking and membrane localization and their involvement in human cardiac disease is described in the review by El Refaey and Mohler . (frontiersin.org)
  • Less commonly, QT interval prolongation results from prolonged depolarization due to a small persistent inward "leak" in cardiac sodium (Na + ) current, I Na ( 3 ) (Figure 1 A). (jci.org)
  • 2. This Article Has Been Brought to You for Free by www.freud-sigmund.compropagation does not follow the normal Stored in both normal cardiac impulseroute. (slideshare.net)
  • The common form of long QT syndrome (LQTS), Romano-Ward syndrome (RWS), is a heterogeneous, autosomal dominant, genetic disease caused by mutations of ion channel genes involving the cell membranes of the cardiac myocytes. (jci.org)
  • At particular risk of this are both heart attack survivors and people with hereditary syndromes that can trigger fatal arrhythmias (even if they have not experienced any symptoms). (hpcwire.com)
  • If extrasystoles are frequent, they may disturb circulation and cardiac function and must be treated. (hus.fi)
  • In reentry, cardiac tissue is repetitively excited by a propagating wave circulating around an obstacle (anatomical reentry) or circulating freely in the tissue as a spiral or scroll wave (functional reentry). (scholarpedia.org)
  • Most arrhythmia does not result in symptoms, but people may experience anxiety , lightheadedness, dizziness, fainting, unusual awareness of the heartbeat, and sensations of fluttering or pounding in the chest. (peacehealth.org)
  • Balse and Boycot provide a review on the basic mechanisms of ion channel trafficking, their interdependence on basal cellular (e.g., local lipid composition) and extracellular (e.g., potassium concentration) factors, and some examples of modifying ion channel trafficking in order to counteract arrhythmias. (frontiersin.org)
  • Sex differences have the potential to impact diagnostic and therapeutic interventions in a wide variety of medical conditions and cardiac arrhythmias are no exception. (springer.com)
  • emphasize on the involvement of autophagy pathways in cardiac ion channel trafficking under disease conditions and the impact of drugs, including antiarrhythmics, on autophagy and subsequent arrhythmic outcomes. (frontiersin.org)
  • Finally, cardiac remodeling processes that are associated with cardiac disease also affect the trafficking of ion channels and gap junction proteins ( Basheer and Shaw, 2016 ). (frontiersin.org)
  • Recent evidence indicates that asymmetric brain activity is particularly important in making the heart more susceptible to ventricular arrhythmias. (nih.gov)
  • Drinking too much caffeine has been associated with arrhythmia in some studies, some healthy people are susceptible to as little as one cup of coffee. (peacehealth.org)
  • Although most people do not experience arrhythmia as a result of caffeine consumption, some healthy people appear to be susceptible to as little as one cup of coffee. (peacehealth.org)
  • In fact, most of the recent advances in cardiac mapping have focused on improvements in multisite recordings within the heart, with the ability to simultaneous record electrical activation from several hundreds of sites having contributed significantly to our understanding of atrial and ventricular arrhythmias. (cogprints.org)
  • A balanced expression of cardiac ion channels at the sarcolemma is of crucial importance for normal action potential formation and thus cardiac function. (frontiersin.org)
  • The balanced expression of many underlying channel proteins that transport ions with great selectivity at the sarcolemma of cardiomyocytes is crucial to maintain regular cardiac contraction throughout one's lifetime. (frontiersin.org)
  • Thus, there is a strong spatial component to reentrant arrhythmias: either a sufficiently large spatial extent is needed to support the initiation and continuation of the arrhythmia, or an appropriate geometry must be present to allow a reentrant circuit. (scholarpedia.org)
  • A ) An illustrative example of a single cardiac cycle detected as spatial and temporal electrical gradients on the ECG. (jci.org)
  • Whether anyone was able to do this I do not know but Bretylium was one of the Cardiac arrhythmia drugs recommended by the American Heart Association in the manuals. (salem-news.com)
  • The drugs used (encainide, flecainide, and moracizine) successfully reduced the amount of PVCs, but consequently led to more arrhythmia-related deaths. (wikipedia.org)
  • Although the use of fish oil to help prevent dangerous heart arrhythmias has received considerable research attention, 1-2,15-17,20,22,23,24,25 the evidence for its effectiveness remains conflicted. (medicalcityhospital.com)