Arntl transcription factors. Medical search

Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.

A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.

The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.

Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.

Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.

Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.

Established cell cultures that have the potential to propagate indefinitely.

A subclass of winged helix DNA-binding proteins that share homology with their founding member fork head protein, Drosophila.

Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

A large superfamily of transcription factors that contain a region rich in BASIC AMINO ACID residues followed by a LEUCINE ZIPPER domain.

A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

A family of zinc finger transcription factors that share homology with Kruppel protein, Drosophila. They contain a highly conserved seven amino acid spacer sequence in between their ZINC FINGER MOTIFS.

The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.

A technique for identifying specific DNA sequences that are bound, in vivo, to proteins of interest. It involves formaldehyde fixation of CHROMATIN to crosslink the DNA-BINDING PROTEINS to the DNA. After shearing the DNA into small fragments, specific DNA-protein complexes are isolated by immunoprecipitation with protein-specific ANTIBODIES. Then, the DNA isolated from the complex can be identified by PCR amplification and sequencing.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

A ubiquitously expressed zinc finger-containing protein that acts both as a repressor and activator of transcription. It interacts with key regulatory proteins such as TATA-BINDING PROTEIN; TFIIB; and ADENOVIRUS E1A PROTEINS.

The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.

A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.

A GATA transcription factor that is expressed in the MYOCARDIUM of developing heart and has been implicated in the differentiation of CARDIAC MYOCYTES. GATA4 is activated by PHOSPHORYLATION and regulates transcription of cardiac-specific genes.

The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

An activating transcription factor that plays a key role in cellular responses to GENOTOXIC STRESS and OXIDATIVE STRESS.

A family of transcription factors characterized by the presence of highly conserved calcineurin- and DNA-binding domains. NFAT proteins are activated in the CYTOPLASM by the calcium-dependent phosphatase CALCINEURIN. They transduce calcium signals to the nucleus where they can interact with TRANSCRIPTION FACTOR AP-1 or NF-KAPPA B and initiate GENETIC TRANSCRIPTION of GENES involved in CELL DIFFERENTIATION and development. NFAT proteins stimulate T-CELL activation through the induction of IMMEDIATE-EARLY GENES such as INTERLEUKIN-2.

A specificity protein transcription factor that regulates expression of a variety of genes including VASCULAR ENDOTHELIAL GROWTH FACTOR and CYCLIN-DEPENDENT KINASE INHIBITOR P27.

The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.

Ubiquitous, inducible, nuclear transcriptional activator that binds to enhancer elements in many different cell types and is activated by pathogenic stimuli. The NF-kappa B complex is a heterodimer composed of two DNA-binding subunits: NF-kappa B1 and relA.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.

A family of transcription factors that control EMBRYONIC DEVELOPMENT within a variety of cell lineages. They are characterized by a highly conserved paired DNA-binding domain that was first identified in DROSOPHILA segmentation genes.

An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.

An activating transcription factor that regulates expression of a variety of GENES including C-JUN GENES; CYCLIN A; CYCLIN D1; and ACTIVATING TRANSCRIPTION FACTOR 3.

An RNA POLYMERASE II specific transcription factor. It plays a role in assembly of the pol II transcriptional preinitiation complex and has been implicated as a target of gene-specific transcriptional activators.

Cis-acting DNA sequences which can increase transcription of genes. Enhancers can usually function in either orientation and at various distances from a promoter.

Nucleic acid sequences involved in regulating the expression of genes.

An E2F transcription factor that interacts directly with RETINOBLASTOMA PROTEIN and CYCLIN A and activates GENETIC TRANSCRIPTION required for CELL CYCLE entry and DNA synthesis. E2F1 is involved in DNA REPAIR and APOPTOSIS.

A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.

The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

A family of transcription factors that contain regions rich in basic residues, LEUCINE ZIPPER domains, and HELIX-LOOP-HELIX MOTIFS.

Activating transcription factors of the MADS family which bind a specific sequence element (MEF2 element) in many muscle-specific genes and are involved in skeletal and cardiac myogenesis, neuronal differentiation and survival/apoptosis.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

A GATA transcription factor that is found predominately in LYMPHOID CELL precursors and has been implicated in the CELL DIFFERENTIATION of HELPER T-CELLS. Haploinsufficiency of GATA3 is associated with HYPOPARATHYROIDISM; SENSORINEURAL HEARING LOSS; and renal anomalies syndrome.

A GATA transcription factor that is specifically expressed in hematopoietic lineages and plays an important role in the CELL DIFFERENTIATION of ERYTHROID CELLS and MEGAKARYOCYTES.

An essential GATA transcription factor that is expressed primarily in HEMATOPOIETIC STEM CELLS.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in fungi.

A family of DNA-binding proteins that are primarily expressed in T-LYMPHOCYTES. They interact with BETA CATENIN and serve as transcriptional activators and repressors in a variety of developmental processes.

A family of transcription factors that contain two ZINC FINGER MOTIFS and bind to the DNA sequence (A/T)GATA(A/G).

A basic helix-loop-helix leucine zipper transcription factor that regulates the CELL DIFFERENTIATION and development of a variety of cell types including MELANOCYTES; OSTEOCLASTS; and RETINAL PIGMENT EPITHELIUM. Mutations in MITF protein have been associated with OSTEOPETROSIS and WAARDENBURG SYNDROME.

Enzymes that oxidize certain LUMINESCENT AGENTS to emit light (PHYSICAL LUMINESCENCE). The luciferases from different organisms have evolved differently so have different structures and substrates.

A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS. Stat1 interacts with P53 TUMOR SUPPRESSOR PROTEIN and regulates expression of GENES involved in growth control and APOPTOSIS.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Activating transcription factors were originally identified as DNA-BINDING PROTEINS that interact with early promoters from ADENOVIRUSES. They are a family of basic leucine zipper transcription factors that bind to the consensus site TGACGTCA of the cyclic AMP response element, and are closely related to CYCLIC AMP-RESPONSIVE DNA-BINDING PROTEIN.

A subunit of NF-kappa B that is primarily responsible for its transactivation function. It contains a C-terminal transactivation domain and an N-terminal domain with homology to PROTO-ONCOGENE PROTEINS C-REL.

A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation.

A cell line derived from cultured tumor cells.

The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.

Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.

The material of CHROMOSOMES. It is a complex of DNA; HISTONES; and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.

A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.

Proteins obtained from the species SACCHAROMYCES CEREVISIAE. The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.

A GATA transcription factor that is expressed predominately in SMOOTH MUSCLE CELLS and regulates vascular smooth muscle CELL DIFFERENTIATION.

An activating transcription factor that regulates the expression of a variety of GENES involved in amino acid metabolism and transport. It also interacts with HTLV-I transactivator protein.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

A transcription factor that takes part in WNT signaling pathway where it may play a role in the differentiation of KERATINOCYTES. The transcriptional activity of this protein is regulated via its interaction with BETA CATENIN.

An activating transcription factor that regulates expression of a variety of genes including C-JUN GENES and TRANSFORMING GROWTH FACTOR BETA2.

A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

One of several general transcription factors that are specific for RNA POLYMERASE III. It is a zinc finger (ZINC FINGERS) protein and is required for transcription of 5S ribosomal genes.

Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

A conserved A-T rich sequence which is contained in promoters for RNA polymerase II. The segment is seven base pairs long and the nucleotides most commonly found are TATAAAA.

Transcription factors that were originally identified as site-specific DNA-binding proteins essential for DNA REPLICATION by ADENOVIRUSES. They play important roles in MAMMARY GLAND function and development.

Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.

A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Cellular DNA-binding proteins encoded by the c-jun genes (GENES, JUN). They are involved in growth-related transcriptional control. There appear to be three distinct functions: dimerization (with c-fos), DNA-binding, and transcriptional activation. Oncogenic transformation can take place by constitutive expression of c-jun.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

A family of transcription factors that share a unique DNA-binding domain. The name derives from viral oncogene-derived protein oncogene protein v-ets of the AVIAN ERYTHROBLASTOSIS VIRUS.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

A class of proteins that were originally identified by their ability to bind the DNA sequence CCAAT. The typical CCAAT-enhancer binding protein forms dimers and consists of an activation domain, a DNA-binding basic region, and a leucine-rich dimerization domain (LEUCINE ZIPPERS). CCAAT-BINDING FACTOR is structurally distinct type of CCAAT-enhancer binding protein consisting of a trimer of three different subunits.

A general transcription factor that is involved in basal GENETIC TRANSCRIPTION and NUCLEOTIDE EXCISION REPAIR. It consists of nine subunits including ATP-DEPENDENT DNA HELICASES; CYCLIN H; and XERODERMA PIGMENTOSUM GROUP D PROTEIN.

A SOXE transcription factor that plays a critical role in regulating CHONDROGENESIS; OSTEOGENESIS; and male sex determination. Loss of function of the SOX9 transcription factor due to genetic mutations is a cause of CAMPOMELIC DYSPLASIA.

An RNA POLYMERASE II specific transcription factor. It may play a role in transcriptional activation of gene expression by interacting with the TATA-BOX BINDING PROTEIN component of TRANSCRIPTION FACTOR TFIID.

Enzymes that catalyze DNA template-directed extension of the 3'-end of an RNA strand one nucleotide at a time. They can initiate a chain de novo. In eukaryotes, three forms of the enzyme have been distinguished on the basis of sensitivity to alpha-amanitin, and the type of RNA synthesized. (From Enzyme Nomenclature, 1992).

A theoretical representative nucleotide or amino acid sequence in which each nucleotide or amino acid is the one which occurs most frequently at that site in the different sequences which occur in nature. The phrase also refers to an actual sequence which approximates the theoretical consensus. A known CONSERVED SEQUENCE set is represented by a consensus sequence. Commonly observed supersecondary protein structures (AMINO ACID MOTIFS) are often formed by conserved sequences.

Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

A signal transducer and activator of transcription that mediates cellular responses to a variety of CYTOKINES. Stat5 activation is associated with transcription of CELL CYCLE regulators such as CYCLIN KINASE INHIBITOR P21 and anti-apoptotic genes such as BCL-2 GENES. Stat5 is constitutively activated in many patients with acute MYELOID LEUKEMIA.

A transcription factor that possesses DNA-binding and E2F-binding domains but lacks a transcriptional activation domain. It is a binding partner for E2F TRANSCRIPTION FACTORS and enhances the DNA binding and transactivation function of the DP-E2F complex.

A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.

Proteins that originate from plants species belonging to the genus ARABIDOPSIS. The most intensely studied species of Arabidopsis, Arabidopsis thaliana, is commonly used in laboratory experiments.

A method for determining the sequence specificity of DNA-binding proteins. DNA footprinting utilizes a DNA damaging agent (either a chemical reagent or a nuclease) which cleaves DNA at every base pair. DNA cleavage is inhibited where the ligand binds to DNA. (from Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.

Proteins containing a region of conserved sequence, about 200 amino acids long, which encodes a particular sequence specific DNA binding domain (the T-box domain). These proteins are transcription factors that control developmental pathways. The prototype of this family is the mouse Brachyury (or T) gene product.

Proteins found in any species of fungus.

Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.

A ubiquitously expressed octamer transcription factor that regulates GENETIC TRANSCRIPTION of SMALL NUCLEAR RNA; IMMUNOGLOBULIN GENES; and HISTONE H2B genes.

Nucleotide sequences of a gene that are involved in the regulation of GENETIC TRANSCRIPTION.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.

A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.

Proteins prepared by recombinant DNA technology.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.

A general transcription factor that plays a major role in the activation of eukaryotic genes transcribed by RNA POLYMERASES. It binds specifically to the TATA BOX promoter element, which lies close to the position of transcription initiation in RNA transcribed by RNA POLYMERASE II. Although considered a principal component of TRANSCRIPTION FACTOR TFIID it also takes part in general transcription factor complexes involved in RNA POLYMERASE I and RNA POLYMERASE III transcription.

A group of transcription factors that were originally described as being specific to ERYTHROID CELLS.

Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

Factors that bind to RNA POLYMERASE III and aid in transcription. They include the assembly factors TFIIIA and TFIIIC and the initiation factor TFIIIB. All combine to form a preinitiation complex at the promotor that directs the binding of RNA POLYMERASE III.

A heterotetrameric transcription factor composed of two distinct proteins. Its name refers to the fact it binds to DNA sequences rich in GUANINE and ADENINE. GA-binding protein integrates a variety of SIGNAL TRANSDUCTION PATHWAYS and regulates expression of GENES involved in CELL CYCLE control, PROTEIN BIOSYNTHESIS, and cellular METABOLISM.

The developmental history of specific differentiated cell types as traced back to the original STEM CELLS in the embryo.

Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. The networks function to ultimately specify expression of particular sets of GENES for specific conditions, times, or locations.

Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.

An early growth response transcription factor that has been implicated in regulation of CELL PROLIFERATION and APOPTOSIS.

A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.

The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.

Deletion of sequences of nucleic acids from the genetic material of an individual.

A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.

Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.

A family of low-molecular weight, non-histone proteins found in chromatin.

Proteins found in any species of bacterium.

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

A transcription factor that takes part in WNT signaling pathway. The activity of the protein is regulated via its interaction with BETA CATENIN. Transcription factor 7-like 2 protein plays an important role in the embryogenesis of the PANCREAS and ISLET CELLS.

An ets proto-oncogene expressed primarily in adult LYMPHOID TISSUE; BRAIN; and VASCULAR ENDOTHELIAL CELLS.

An enzyme capable of hydrolyzing highly polymerized DNA by splitting phosphodiester linkages, preferentially adjacent to a pyrimidine nucleotide. This catalyzes endonucleolytic cleavage of DNA yielding 5'-phosphodi- and oligonucleotide end-products. The enzyme has a preference for double-stranded DNA.

A polynucleotide consisting essentially of chains with a repeating backbone of phosphate and ribose units to which nitrogenous bases are attached. RNA is unique among biological macromolecules in that it can encode genetic information, serve as an abundant structural component of cells, and also possesses catalytic activity. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)

The biosynthesis of DNA carried out on a template of RNA.

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. (1/398)

The Drosophila CLOCK (dCLOCK) and CYCLE (CYC) (also referred to as dBMAL1) proteins are members of the basic helix-loop-helix PAS (PER-ARNT-SIM) superfamily of transcription factors and are required for high-level expression of the circadian clock genes period (per) and timeless (tim). Several lines of evidence indicate that PER, TIM, or a PER-TIM heterodimer somehow inhibit the transcriptional activity of a putative dCLOCK-CYC complex, generating a negative-feedback loop that is a core element of the Drosophila circadian oscillator. In this report we show that PER and/or TIM inhibits the binding of a dCLOCK-CYC heterodimer to an E-box-containing DNA fragment that is present in the 5' nontranscribed region of per and acts as a circadian enhancer element. Surprisingly, inhibition of this DNA binding activity by PER, TIM, or both is not accompanied by disruption of the association between dCLOCK and CYC. The results suggest that the interaction of PER, TIM, or both with the dCLOCK-CYC heterodimer induces a conformational change or masks protein regions in the heterodimer, leading to a reduction in DNA binding activity. Together with other findings, our results strongly suggest that daily cycles in the association of PER and TIM with the dCLOCK-CYC complex probably contribute to rhythmic expression of per and tim. (+info)

mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. (2/398)

We determined that two mouse cryptochrome genes, mCry1 and mCry2, act in the negative limb of the clock feedback loop. In cell lines, mPER proteins (alone or in combination) have modest effects on their cellular location and ability to inhibit CLOCK:BMAL1 -mediated transcription. This suggested cryptochrome involvement in the negative limb of the feedback loop. Indeed, mCry1 and mCry2 RNA levels are reduced in the central and peripheral clocks of Clock/Clock mutant mice. mCRY1 and mCRY2 are nuclear proteins that interact with each of the mPER proteins, translocate each mPER protein from cytoplasm to nucleus, and are rhythmically expressed in the suprachiasmatic circadian clock. Luciferase reporter gene assays show that mCRY1 or mCRY2 alone abrogates CLOCK:BMAL1-E box-mediated transcription. The mPER and mCRY proteins appear to inhibit the transcriptional complex differentially. (+info)

Requirement of circadian genes for cocaine sensitization in Drosophila. (3/398)

The circadian clock consists of a feedback loop in which clock genes are rhythmically expressed, giving rise to cycling levels of RNA and proteins. Four of the five circadian genes identified to date influence responsiveness to freebase cocaine in the fruit fly, Drosophila melanogaster. Sensitization to repeated cocaine exposures, a phenomenon also seen in humans and animal models and associated with enhanced drug craving, is eliminated in flies mutant for period, clock, cycle, and doubletime, but not in flies lacking the gene timeless. Flies that do not sensitize owing to lack of these genes do not show the induction of tyrosine decarboxylase normally seen after cocaine exposure. These findings indicate unexpected roles for these genes in regulating cocaine sensitization and indicate that they function as regulators of tyrosine decarboxylase. (+info)

Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. (4/398)

Cryptochrome (CRY), a photoreceptor for the circadian clock in Drosophila, binds to the clock component TIM in a light-dependent fashion and blocks its function. In mammals, genetic evidence suggests a role for CRYs within the clock, distinct from hypothetical photoreceptor functions. Mammalian CRY1 and CRY2 are here shown to act as light-independent inhibitors of CLOCK-BMAL1, the activator driving Per1 transcription. CRY1 or CRY2 (or both) showed light-independent interactions with CLOCK and BMAL1, as well as with PER1, PER2, and TIM. Thus, mammalian CRYs act as light-independent components of the circadian clock and probably regulate Per1 transcriptional cycling by contacting both the activator and its feedback inhibitors. (+info)

Cycling vrille expression is required for a functional Drosophila clock. (5/398)

We identified a novel regulatory loop within Drosophila's circadian clock. A screen for clock-controlled genes recovered vrille (vri), a transcription factor essential for embryonic development. vri is expressed in circadian pacemaker cells in larval and adult brains. vri RNA levels oscillate with a circadian rhythm. Cycling is directly regulated by the transcription factors dCLOCK and CYCLE, which are also required for oscillations of period and timeless RNA. Eliminating the normal vri cycle suppresses period and timeless expression and causes long-period behavioral rhythms and arrhythmicity, indicating that cycling vri is required for a functional Drosophila clock. We also show that dCLOCK and VRI independently regulate levels of a neuropeptide, pigment dispersing factor, which appears to regulate overt behavior. (+info)

ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. (6/398)

One major function of the hypothalamus is to maintain homeostasis by modulating the secretion of pituitary hormones. The paraventricular (PVN) and supraoptic (SON) nuclei are major integration centers for the output of the hypothalamus to the pituitary. The bHLH-PAS transcription factor SIM1 is crucial for the development of several neuroendocrine lineages within the PVN and SON. bHLH-PAS proteins require heterodimerization for their function. ARNT, ARNT2, and BMAL1 are the three known general heterodimerization partners for bHLH-PAS proteins. Here, we provide evidence that Sim1 and Arnt2 form dimers in vitro, that they are co-expressed in the PVN and SON, and that their loss of function affects the development of the same sets of neuroendocrine cell types within the PVN and SON. Together, these results implicate ARNT2 as the in vivo dimerization partner of SIM1 in controlling the development of these neuroendocrine lineages. (+info)

dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex. (7/398)

In Drosophila melanogaster four circadian clock proteins termed PERIOD (PER), TIMELESS (TIM), dCLOCK (dCLK), and CYCLE (CYC/dBMAL1) function in a transcriptional feedback loop that is a core element of the oscillator mechanism. dCLK and CYC are members of the basic helix-loop-helix (bHLH)/PAS (PER-ARNT-SIM) superfamily of transcription factors and are required for high-level expression of per and tim and repression of dClk, whereas PER and TIM inhibit dCLK-CYC-mediated transcription and lead to the activation of dClk. To understand further the dynamic regulation within the circadian oscillator mechanism, we biochemically characterized in vivo-produced CYC, determined the interactions of the four clock proteins, and calculated their absolute levels as a function of time. Our results indicate that throughout a daily cycle the majority of the dCLK present in adult heads stably interacts with CYC, indicating that CYC is the primary in vivo partner of dCLK. dCLK-CYC dimers are bound by PER and TIM during the late evening and early morning, suggesting the formation of a tetrameric complex with impaired transcriptional activity. Although dCLK is present in limiting amounts and CYC is by far the most abundant of the four clock proteins that have been examined, PER and TIM appear to interact preferentially with dCLK. Our results suggest that dCLK is the main component regulating the daily abundance of transcriptionally active dCLK-CYC complexes. (+info)

Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. (8/398)

Most clock genes encode transcription factors that interact to elicit cooperative control of clock function. Using a two-hybrid system approach, we have isolated two different partners of zebrafish (zf) CLOCK, which are similar to the mammalian BMAL1 (brain and muscle arylhydrocarbon receptor nuclear translocator-like protein 1). The two homologs, zfBMAL1 and zfBMAL2, contain conserved basic helix-loop-helix-PAS (Period-Arylhydrocarbon receptor-Singleminded) domains but diverge in the carboxyl termini, thus bearing different transcriptional activation potential. As for zfClock, the expression of both zfBmals oscillates in most tissues in the animal. However, in many tissues, the peak, levels, and kinetics of expression are different between the two genes and for the same gene from tissue to tissue. These results support the existence of independent peripheral oscillators and suggest that zfBMAL1 and zfBMAL2 may exert distinct circadian functions, interacting differentially with zfCLOCK at various times in different tissues. Our findings also indicate that multiple controls may be exerted by the central clock and/or that peripheral oscillators can differentially interpret central clock signals. (+info)

bHLH transcription factors are often important in development or cell activity. For one, BMAL1-Clock (also called ARNTL) is a ... In general, transcription factors (including this type) are dimeric, each with one helix containing basic amino acid residues ... The word "basic" does not refer to complexity but to the chemistry of the motif because transcription factors in general ... Neurogenins MAX C-Myc, N-Myc TCF4 (Transcription Factor 4) These proteins contain two additional PAS domains after the bHLH ...

https://en.wikipedia.org/wiki/Basic_helix–loop–helix

Much like CYCLE, the ARNTL proteins have a basic helix-loop-helix and a PAS domain containing transcription factors responsible ... and transcription factor activity. Other non-arthropods containing the functional ortholog of the Drosophila cycle ARNTL and ... repressing CYC-CLK dependent transcription. Thus, CLK and CYC act as positive factors and PER and TIM as negative factors. CYC ... The cyc gene is located on the left arm of chromosome 3 and codes for a transcription factor containing a basic helix-loop- ...

https://en.wikipedia.org/wiki/Cycle_(gene)

... encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains. The human ARNTL gene has a ... is a paralog of Arntl (Bmal1) that encodes for a basic helix-loop-helix PAS domain transcription factor. It, too, has been ... and hypoxia-inducible factors. The names BMAL1 and ARNTL were adopted in later papers. One of ARNTL protein's earliest ... in March under the name MOP3 and Ikeda and Nomura in April as part of a superfamily of PAS domain transcription factors. In ...

https://en.wikipedia.org/wiki/ARNTL

This protein can bind to and activate the promoter of the ARNTL (BMAL1) gene, a transcription factor central to the generation ... The transcription factor is essential for lymphoid organogenesis, in particular lymph nodes and Peyer's patches, but not the ... The RORγ protein is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear receptors. Although the ... RORγ is a member of the nuclear receptor family of transcription factors. It is mainly expressed in immune cells (Th17 cells) ...

https://en.wikipedia.org/wiki/RAR-related_orphan_receptor_gamma

... better known as BMAL1 or ARNTL, revealed in 1998 that its role as a partner of the bHLH-PAS transcription factor CLOCK was ... BMAL1 and CLOCK are now the two most well recognized bHLH-PAS domain transcription factors. Later work revealed that Bmal1 is ... These transcription factors were initially named MOP1-5. Hogenesch's later characterization of MOP3, ... In 1999 Hogenesch completed a Ph.D. in Neuroscience at Northwestern University's Chicago campus, studying transcription factors ...

https://en.wikipedia.org/wiki/John_B._Hogenesch

It is a type of hypoxia-inducible factor, a group of transcription factors involved in the physiological response to oxygen ... EPAS1 has been shown to interact with aryl hydrocarbon receptor nuclear translocator and ARNTL. GRCh38: Ensembl release 89: ... Tian H, Hammer RE, Matsumoto AM, Russell DW, McKnight SL (November 1998). "The hypoxia-responsive transcription factor EPAS1 is ... Cross-talk between basic helix-loop-helix/per-Arnt-Sim homology transcription factors". The Journal of Biological Chemistry. ...

https://en.wikipedia.org/wiki/EPAS1

... are recruited to DNA-bound transcription factors to activate transcription. Coactivators can associate with promoters and ... Human and animal proteins: ARNTL (BMAL1) ATF1 ATF4 (CREB2) BRCA1 CREB Cubitus interruptus (in D. melanogaster) ELK4 (SAP1) ... Goto NK, Zor T, Martinez-Yamout M, Dyson HJ, Wright PE (November 2002). "Cooperativity in transcription factor binding to the ... It serves as a docking site for the formation of heterodimers between the coactivator and specific transcription factors. ...

https://en.wikipedia.org/wiki/KIX_domain

The NPAS2 protein is a member of the basic helix-loop-helix (bHLH)-PAS transcription factor family and is expressed in the SCN ... ARNTL, and CLOCK polymorphisms. These genes may influence seasonal variations through metabolic factors such as body weight and ... Neuronal PAS domain protein 2 (NPAS2) also known as member of PAS protein 4 (MOP4) is a transcription factor protein that in ... NPAS2 has been shown to interact with: ARNTL (also known as BMAL1). Like Clock, Npas2 mRNA cycles with a similar phase to that ...

https://en.wikipedia.org/wiki/NPAS2

... is recognized and bound by transcription factors to initiate gene transcription. Once the transcription factors bind to the ... There are several proteins that bind to the E-box and affect gene transcription. The CLOCK-ARNTL (BMAL1) complex is an integral ... 2002). "Evidence that E-box promoter elements and MyoD transcription factors play a role in the induction of cathepsin B gene ... MYC (c-Myc), a gene that codes for a transcription factor Myc, is important in regulating mammalian cell proliferation and ...

https://en.wikipedia.org/wiki/E-box

This results in an inhibition of the transcription factors of per and tim thereby lowering the respective mRNA levels and ... Bmal1 - Bmal1 also known as ARNTL or Aryl hydrocarbon receptor nuclear translocator-like, encodes a protein that forms a ... It has been shown to affect the period of circadian rhythms through its repression of transcription factors. This was found ... Clock - Clock, also known as Circadian Locomotor Output Cycles Kaput, is a transcription factor in the circadian pacemaker of ...

https://en.wikipedia.org/wiki/Oscillating_gene

The first is the basic-region (b), which is involved in the binding of the transcription factor to DNA. The second is the helix ... In addition to the protein interactions mentioned above, AhR has also been shown to interact with the following: AIP ARNTL ... The bHLH motif is located in the N-terminal of the protein and is a common entity in a variety of transcription factors. ... Sequential recruitment of transcription factors and differential phosphorylation of C-terminal domain of RNA polymerase II at ...

https://en.wikipedia.org/wiki/Aryl_hydrocarbon_receptor

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia- ... HIF1A has been shown to interact with: ARNTL, ARNT, CREBB, EP300, HIF1AN, Mdm2, NR4A, P53, PSMA7, STAT3, UBC, VH and VHL. GR ( ... The human HIF1A gene encodes for the alpha subunit, HIF1A of the transcription factor hypoxia-inducible factor (HIF1). Its ... "Entrez Gene: HIF1A hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)". Wang GL, Jiang BH ...

https://en.wikipedia.org/wiki/HIF1A

Hung MS, Avner P, Rogner UC (September 2006). "Identification of the transcription factor ARNTL2 as a candidate gene for the ... Recent work suggest that this interaction may be in concert with ARNTL/CLOCK heterodimeric complexes. Arntl (Bmal1) GRCh38: ... Transcription factors, PAS-domain-containing proteins, All stub articles, Human chromosome 12 gene stubs). ... "cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: its mRNA expression, subcellular distribution, ...

https://en.wikipedia.org/wiki/ARNTL2

... their transcription factors, and access of defined chromatin regions to the transcription factors, however, it still remains ... The circadian clock and ILC interactions have been demonstrated by studying the regulation of the master gene clock Arntl. Its ... Both cell types produce IFN-γ as their principle cytokine and require the transcription factor T-bet to do so. Both cells can ... October 2012). "The transcription factor GATA3 is essential for the function of human type 2 innate lymphoid cells". Immunity. ...

https://en.wikipedia.org/wiki/Innate_lymphoid_cell

... which encode closely related MYB transcription factors that regulate circadian rhythms in Arabidopsis, as well as PRR 7 and 9 ( ... Actigraphy (also known as actimetry) ARNTL ARNTL2 Bacterial circadian rhythms Circadian rhythm sleep disorders, such as ... Obesity and diabetes are associated with lifestyle and genetic factors. Among those factors, disruption of the circadian ... in A.thaliana.LNKs binds to the 5'region of PRR5 and TOC1 and interacts with RNAP II and other transcription factors. Moreover ...

https://en.wikipedia.org/wiki/Circadian_rhythm

ARNTL Transcription Factors Entry term(s). Aryl Hydrocarbon Receptor Nuclear Translocator like Transcription Factors Aryl ... MOP3 Transcription Factor. MOP9 Transcription Factor. Member of PAS Protein 3. Member of PAS Protein 9. Transcription Factor, ... 2010; BMAL1 PROTEIN (now ARNTL TRANSCRIPTION FACTORS) was indexed under BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS 2006-2009 ... MOP9 Transcription Factor Member of PAS Protein 9 Transcription Factor, MOP9 Aryl Hydrocarbon Receptor Nuclear Translocator- ...

https://decs.bvsalud.org/en/ths/resource/?id=53617&filter=ths_exact_term&q=FACTORES+DE+TRANSCRIPCI%C3%93N+ARNTL

Fatores de Transcrição ARNTL. ARNTL Transcription Factors. Factores de Transcripción ARNTL. Fototropinas. Phototropins. ... Chromatin Assembly Factor-1. Factor 1 de Ensamblaje de la Cromatina. Fator 1 de Modelagem do Nucleossomo. Nucleosome Assembly ...

https://decs.bvs.br/P/new_2010.htm

Bmal1 (Brain and muscle arnt-like, or Arntl) is a bHLH/PAS domain transcription factor central to the transcription/translation ... The activation of Akt induced NF-κB translocation into the nucleus thus releasing proinflammatory factors including tumor ... Univariable and multivariable logistic regression were performed to determine factors associated with GPC3-positive HCC. The ... necrosis factor-α (TNF-α) and interleukin-8. The release of these inflammatory factors concomitantly induced T cell stimulation ...

https://pesquisa.bvsalud.org/controlecancer/?lang=pt&q=au:Chen,+Yongjun

https://decs2019.bvsalud.org/P/new_2010.htm

https://decs2012.bvsalud.org/P/new_2010.htm

https://decs2010.bvsalud.org/P/new_2010.htm

Basic Helix-Loop-Helix Transcription Factors. *ARNTL Transcription Factors. *Basic Helix-Loop-Helix Leucine Zipper ... Ubiquitously expressed basic HELIX-LOOP-HELIX MOTIF transcription factors. They bind CANNTG sequences in the promoters of a ... Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif. Biochem J. 2012 Aug 15; 446(1):89-98. ... "Upstream Stimulatory Factors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...

https://profiles.uchicago.edu/profiles/display/28707

Circadian Rhythm Genes and Posttraumatic Stress Symptoms Identifies a Potential Functional Allele in the Transcription Factor ... Association of ARNTL and PER1 genes with Parkinsons disease: a case-control study of Han Chinese. Scientific reports 2015 5 ... PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of ...

https://phgkb.cdc.gov/PHGKB/searchSummary.action?firstQuery=Stress+and+CLOCK&Mysubmit=Search

In Chriss lab, I worked on identifying and characterizing new members of the bHLH-PAS class of transcription factors - several ... Now, if you go to Google and search a clock gene such as Bmal1, the first link that comes up is the Arntl entry in Wikipedia. ...

https://blog.coturnix.org/category/clock-interviews/

Human ATF1(Activating Transcription Factor 1) ELISA Kit. *Human ATP6AP2(ATPase, H+ Transporting, Lysosomal Accessory Protein 2 ... Human ARNTL(Aryl Hydrocarbon Receptor Nuclear Translocator Like Protein) ELISA Kit. *Human AS3MT(Arsenic, 3-Oxidation State ... Human ATF1(Activating Transcription Factor 1) ELISA Kit. *Human ATP6AP2(ATPase, H+ Transporting, Lysosomal Accessory Protein 2 ... Pig IGFBP1(Insulin Like Growth Factor Binding Protein 1) ELISA Kit. *Pig IGFBP3(Insulin Like Growth Factor Binding Protein 3) ...

https://www.resourcerecovery.be/human-h1histone-h1-elisa-kit/

Human ATF1(Activating Transcription Factor 1) ELISA Kit. *Human ATP6AP2(ATPase, H+ Transporting, Lysosomal Accessory Protein 2 ... Human ARNTL(Aryl Hydrocarbon Receptor Nuclear Translocator Like Protein) ELISA Kit. *Human AS3MT(Arsenic, 3-Oxidation State ... Rat PDGFB(Platelet Derived Growth Factor Subunit B) ELISA Kit. Mouse Platelet Derived Growth Factor Subunit B (PDGFB) ELISA Kit ... Mouse IGFBP2(Insulin Like Growth Factor Binding Protein 2) ELISA Kit. *Mouse IGFBP6(Insulin Like Growth Factor Binding Protein ...

https://scalegen.com/rat-pdgfbplatelet-derived-growth-factor-subunit-b-elisa-kit/

Interestingly, MYC and BMAL1 are basic helix-loop-helix DNA-binding transcription factors, which recognize the same E-box ... ARNTL) expression is strongly associated with a favorable clinical outcome and stage, while high REV-ERBα (NR1D1) expression ... The ABCA10 transcription start site was used as a negative control DNA region for MYCN. The BMAL1-ChIP assays were performed ... To activate MYCN transcription, cells were treated with 1 µM 4-hydroxytamoxifen (Sigma Aldrich# T176) for 48 h. Cell lines were ...

https://www.nature.com/articles/s41467-021-24196-4?error=cookies_not_supported&code=709dc144-113f-4e96-981d-01ebc61e223b

... cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus ... Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, ... Transcription factor binding. Specific Function:. Acts as a substrate adapter protein for the E3 ubiquitin ligase complex ... Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response ...

http://www.t3db.ca/toxins/T3D0320

... and predicted novel regulatory transcription factors. The lineage tree highlighted a prominent bifurcation between cortical and ... ARNTL;GUCD1;DENND4A;GAB1;WSB2;RPL39L;FMNL3;RNF157;C8orf4;FERMT2;LOC100131089;ACOXL;ARHGDIG;NCOA5;SSR4;SURF6;PHF6;PAQR7;SRPR; ...

https://bioinfo.uth.edu/scrnaseqdb/index.php?r=gseTable/datasetView&gse=GSE86977&group=56&page=2

ARNTL!0.72!48.42!ARNTL;;chr19:12273866..12273935,+!p1@ZNF136!0.72!42.69!ZNF136;;chr1:157108282..157108347,-!p3@ETV3!0.72!9.49! ... Transcription Factors. *Coexpression module. *Time Courses Overview. Mouse. *Samples. *Transcription Factors. *Coexpression ...

https://fantom.gsc.riken.jp/resource_browser/index.php?title=FF:11903-125F4&action=edit&oldid=732151

Rat STAT2(Signal Transducer And Activator Of Transcription 2) ELISA Kit. *Pig NT-ProBNP(N-Terminal Pro-Brain Natriuretic ... Mouse ARNTL(Aryl Hydrocarbon Receptor Nuclear Translocator Like Protein) ELISA Kit. *Pig IgM(Immunoglobulin M) ELISA Kit ... Rat FGF23(Fibroblast Growth Factor 23) ELISA Kit. Rat FGF23(Fibroblast Growth Factor 23) ELISA Kit. To Order Contact us: [email ... Cattle FGF2(Fibroblast Growth Factor 2, Basic) ELISA Kit. *Human RKHD1(Ring Finger And KH Domain Containing Protein 1) ELISA ...

https://www.hiv-pharmacogenomics.org/rat-fgf23fibroblast-growth-factor-23-elisa-kit/

Human TCF7L2(Transcription Factor 7 Like Protein 2) ELISA Kit. *Human THSD7A(Thrombospondin Type I Domain Containing Protein 7A ... Mouse ARNTL(Aryl Hydrocarbon Receptor Nuclear Translocator Like Protein) ELISA Kit. *Mouse BCHE(Butyrylcholinesterase) ELISA ... Rat PDGFRb(Platelet Derived Growth Factor Receptor Beta) ELISA Kit. *Rat PDGFRL(Platelet Derived Growth Factor Receptor Like ... Human VEGF183(Vascular Endothelial Growth Factor 183) ELISA Kit. *Human VEGF189(Vascular Endothelial Growth Factor 189) ELISA ...

https://antibody-tech.com/human-ttc39btetratricopeptide-repeat-domain-protein-39b-elisa-kit/

DNA-binding Transcription Factor Activity, RNA Polymerase II-specific. *Retinoic Acid Binding ... 97 interacting genes: ACTN4 AKT1 ALOX15B ALX1 ARID1A ARID5A ARNTL BAG1 BBS4 BTG1 CCND3 CCNDBP1 CDK7 CEBPA CLOCK CNOT1 COPS2 ... RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding. *RNA Polymerase II Cis-regulatory Region ...

https://hagrid.dbmi.pitt.edu/wiki-MPM/index.php/pair/view/55806/5914

1D), led to a significant upregulation of cancer driver genes, such as AKT1, ARNTL, CAV1, CAV2, IL6, and especially ERG (15.71 ... 3J, K). Therefore, IGF1 acts as an autocrine growth factor for both AR+ and AR− PC cells and accounts for much of the ... The functions of signal transducers and activators of transcriptions 1 and 3 as cytokine-inducible proteins. J Interferon ... Kim R, Emi M, Tanabe K, Uchida Y, Toge T. The role of Fas ligand and transforming growth factor beta in tumor progression: ...

https://jhoonline.biomedcentral.com/articles/10.1186/s13045-022-01357-6

Horse VEGFA(Vascular Endothelial Growth Factor A) ELISA Kit. *Human AGGF1(Angiogenic Factor With G Patch And FHA Domains 1) ... rna transcription, rna vaccine, rna virus, rna vs dna, rna-seq, rna-seq analysis, rnafold, rnai, rnao, rnascope, rnase, rnaseq ... Rat ARNTL(Aryl Hydrocarbon Receptor Nuclear Translocator Like Protein) ELISA Kit. *Rat ARO(Aromatase) ELISA Kit ... Mouse PDGFC(Platelet Derived Growth Factor C) ELISA Kit. *Mouse PDGFRL(Platelet Derived Growth Factor Receptor Like Protein) ...

https://www.chemcarbindia.com/tag/rna-seq-analysis/

Earlier findings have linked ARNTL to infertility in mice, but this is the first time when any polymorphism of these genes is ... ARNTL and NPAS2 gene variants were associated with reproduction and with seasonal variation. ... Critical Roles of the Circadian Transcription Factor BMAL1 in Reproductive Endocrinology and Fertility. Jiang Y, Li S, Xu W, ... cDNA cloning of a novel bHLH-PAS transcription factor superfamily gene, BMAL2: Its mRNA expression, subcellular distribution, ...

https://pubmed.ncbi.nlm.nih.gov/20368993

ARNTL Transcription Factors Actions. * Search in PubMed * Search in MeSH * Add to Search ... Rhythmic transcription: the molecular basis of circadian melatonin synthesis. Foulkes NS, Whitmore D, Sassone-Corsi P. Foulkes ...

http://www.ncbi.nlm.nih.gov/pubmed/10420435

MeSH Terms: ARNTL Transcription Factors/metabolism; Amyloid beta-Peptides/metabolism*; Animals; Apolipoproteins E/metabolism; ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=3398400

MeSH Terms: ARNTL Transcription Factors/genetics; ARNTL Transcription Factors/metabolism; Amino Acid Sequence; Animals; CLOCK ...

https://tools.niehs.nih.gov/portfolio/index.cfm?do=portfolio.publicationDetail&id=3903665

The mammalian core TTL consists of the transcription factors circadian locomotor output cycles kaput (CLOCK), neuronal PAS ... domain protein 2 (NPAS2), and brain and muscle ARNT-like 1 (BMAL1 or ARNTL) that bind to E-box enhancer elements in the ... promoters of Period (Per1-3) and Cryptochrome (Cry1/2) genes, thereby activating their transcription. PER and CRY proteins form ...

http://www.medscape.com/viewarticle/750237

Transcription Factors [D12.776.930] * Basic Helix-Loop-Helix Transcription Factors [D12.776.930.125] * ARNTL Transcription ... ARNTL Transcription Factors [D12.776.260.103.249] * Basic Helix-Loop-Helix Leucine Zipper Transcription Factors [D12.776. ... 2010; BMAL1 PROTEIN (now ARNTL TRANSCRIPTION FACTORS) was indexed under BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS 2006-2009 ... MOP3 Transcription Factor MOP9 Transcription Factor Member of PAS Protein 3 Member of PAS Protein 9 Registry Number. 0. Public ...

https://meshb.nlm.nih.gov/record/ui?ui=D056930

Transcription Factors:. ADNP, AFF1, AFF2, AFF3, AFF4, ALX1, ALX3, ALX4, AP5Z1, ARID1A, ARID1B, ARID2, ARID5B, ARNT, ARNT2, ... ARNTL, ARNTL2, ARX, ASCL1, ATF3, ATF6, ATOH1, ATOH7, BACH1, BACH2, BARX1, BATF2, BCL11A, BCL11B, BHLHA9, BHLHE40, BNC2, ...

http://grants.nih.gov/grants/guide/rfa-files/RFA-TR-22-030.html

https://meshb-prev.nlm.nih.gov/record/ui?ui=D056930

https://decs.bvsalud.org/en/ths/resource/?id=53617&filter=ths_exact_term&q=ARNTL+TRANSCRIPTION+FACTORS

N0000167356 Aristolochic Acids N0000169157 Armadillo Domain Proteins N0000166430 Armin N0000180262 ARNTL Transcription Factors ... Factor Brn-3A N0000169848 Transcription Factor Brn-3B N0000169847 Transcription Factor Brn-3C N0000169876 Transcription Factor ... Factor DP1 N0000169840 Transcription Factor Pit-1 N0000169958 Transcription Factor RelA N0000169957 Transcription Factor RelB ... Factors N0000169973 E2F1 Transcription Factor N0000169969 E2F2 Transcription Factor N0000169970 E2F3 Transcription Factor ...

https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/StructuralClass%202012-06-04.txt

... transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and ... Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). This gene ... heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during ... Activates transcription as a heterodimer with E proteins. Regulates gene expression differentially, depending on dimer ...

https://pharos.nih.gov/targets/TWIST1

It positively regulates gene expression of CIRCADIAN CLOCK PROTEINS AND PEPTIDES, including ARNTL TRANSCRIPTION FACTORS and ... A rare disorder of the immune system with wide-ranging effects which include GATA2 Transcription Factor dysfunction, ... Progranulin has growth-factor like effects and is expressed over a broad range of tissues. Under-expression of progranulin is ... HN - 2019 (1984) MH - Race Factors UI - D000076782 MN - N5.715.350.463 MS - A constituent element or influence that could be ...

https://data.lhncbc.nlm.nih.gov/public/ii/information/MBR/Stree/2019/meshnew2019.txt

https://nlmpubs.nlm.nih.gov/projects/mesh/.newterms/meshnew2019.txt

https://decs2011.bvsalud.org/P/new_2010.htm

https://decs2016.bvsalud.org/P/new_2010.htm

https://decs2020.bvsalud.org/P/new_2010.htm

https://decs2015.bvsalud.org/P/new_2010.htm

https://decs2017.bvsalud.org/P/new_2010.htm

https://decs2018.bvsalud.org/P/new_2010.htm

ARNTL Transcription Factors. Fatores de Transcrição ARNTL. Factores de Transcripción ARNTL. Antibodies, Neutralizing. ... Chromatin Assembly Factor-1. Fator 1 de Modelagem da Cromatina. Factor 1 de Ensamblaje de la Cromatina. ...

https://decs2010.bvsalud.org/I/new_2010.htm

https://decs2014.bvsalud.org/P/new_2010.htm

https://decs2013.bvsalud.org/P/new_2010.htm

4. The role of E26 transformation-specific variant transcription factor 5 in colorectal cancer cell proliferation and cell ... 5. Aryl hydrocarbon receptor nuclear translocator-like (ARNTL/BMAL1) is associated with bevacizumab resistance in colorectal ... 2. ETS variant 5 promotes colorectal cancer angiogenesis by targeting platelet-derived growth factor BB.. Cheng X; Jin Z; Ji X ... cancer via regulation of vascular endothelial growth factor A.. Burgermeister E; Battaglin F; Eladly F; Wu W; Herweck F; ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=33099574&mod=related&page=1&from=&outid=&proj=

Simple metabolites dictate the actions of specific transcription factors that sense the minute-to-minute cellular environment ... It does not take into account different metabolic pathways in which key metabolites bind to transcription factors and alter ... and brain and muscle ARNTL-like protein 1 (BMAL1). Both of these are transcriptional factors that regulate the expression of ... NAD+ enhances the interaction of CtBP with target transcription factors (Zhang et al. 2002). Furthermore, CtBP is a metabolic ...

https://arcr.niaaa.nih.gov/volume/35/1/alcohol-metabolism-and-epigenetics-changes

The protein encoded by this gene is a ligand-activated helix-loop-helix transcription factor involved in the regulation of ... this protein moves to the nucleus and stimulates transcription of target genes. [provided by RefSeq, Sep 2015] ... of target gene promoters and activates their transcription (PubMed:28602820). ... Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT ...

https://pharos.ncats.nih.gov/targets/AHR

cyclic AMP-dependent transcription factor ATF-2. Atf2. CREB-2, HB15, CREBP1. 487. nucleus, cytoplasm, mitochonrdion outer ... H3K14, ARNTL/BMAL1, NR3C1/GR. P45481. CREB-binding protein. Crebbp. CBP. 2441. nucleus, cytoplasm H2BK12, H2BK15, H3K18, H3K23 ... general transcription factor 3C polypeptide 4. Gtf3c4. TF3C-delta, TFIIIC90, KAT12. 817. nucleus. H3K14. ... Transcription initiation factor TFIID subunit 1-like. Taf1L. TAF(II)210. 1826. nucleus. ?. ...

https://esbl.nhlbi.nih.gov/Databases/KSBP2/Targets/Lists/ATS/

BMAL1 Transcriptional Circadian Genes Heterodimer Protein Activates Descriptor Upstream Stimula Gene Expression ELISA Kit Metabolic Tree Specific Impact Human Role Treatment ARNTL2 Gene Epidermal Proteins

Using human melanocytes and melanoma cells under synchronized clock conditions, we observed that the microphthalmia-associated transcription factor (MITF), a rate-limiting protein in melanin synthesis, is expressed rhythmically with 24-hr periodicity in the presence of circadian clock protein, BMAL1. (nih.gov)
Represses the activity of the circadian transcriptional activator: NPAS2-ARNTL/BMAL1 heterodimer (By similarity). (nih.gov)
12. PI3K regulates BMAL1/CLOCK-mediated circadian transcription from the Dbp promoter. (nih.gov)
Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. (nih.gov)

This self-sustained time-keeping system is generated and maintained by an endogenous molecular machine, the circadian clock, which is a transcriptional mechanism composed of the transcription factors CLOCK and BMAL and their co-repressors, PER and CRY. (nih.gov)

1. A large scale shRNA barcode screen identifies the circadian clock component ARNTL as putative regulator of the p53 tumor suppressor pathway. (nih.gov)
5. Preferential inhibition of BMAL2-CLOCK activity by PER2 reemphasizes its negative role and a positive role of BMAL2 in the circadian transcription. (nih.gov)
9. Three circadian clock genes Per2, Arntl, and Npas2 contribute to winter depression. (nih.gov)
Evaluation of the Association Between Genetic Variants in Circadian Rhythm Genes and Posttraumatic Stress Symptoms Identifies a Potential Functional Allele in the Transcription Factor TEF. (cdc.gov)

They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. (nih.gov)
Se combinan con las PROTEÍNAS CLOCK para formar factores de transcripción heterodiméricos específicos para ELEMENTOS E-BOX y estimular la transcripción de varios genes E-box que intervienen en la regulación del ciclo. (bvsalud.org)
Association of ARNTL and PER1 genes with Parkinson's disease: a case-control study of Han Chinese. (cdc.gov)

Activates transcription as a heterodimer with E proteins. (nih.gov)
The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820). (nih.gov)

33) and the apical receptors of the Fourier protein, the world associated to work induces well viable in some processes of transcription energy. (evakoch.com)

Upstream stimulatory factor 1 activates GATA5 expression through an E-box motif. (uchicago.edu)

Upstream Stimulatory Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)

This graph shows the total number of publications written about "Upstream Stimulatory Factors" by people in this website by year, and whether "Upstream Stimulatory Factors" was a major or minor topic of these publications. (uchicago.edu)
Below are the most recent publications written about "Upstream Stimulatory Factors" by people in Profiles. (uchicago.edu)

Metabolites, including those generated during ethanol metabolism, can impact disease states by binding to transcription factors and/or modifying chromatin structure, thereby altering gene expression patterns. (nih.gov)
It does not take into account different metabolic pathways in which key metabolites bind to transcription factors and alter gene expression patterns that contribute to the observable characteristics (the phenotype) of a given disease. (nih.gov)
An important mechanism in the regulation of gene expression, particularly its first step (transcription), is chromatin remodeling. (nih.gov)

Description: Quantitativesandwich ELISA kit for measuring Rat fibroblast growth factor 23 (FGF23) in samples from serum, plasma, cell culture supernates, tissue homogenates. (hiv-pharmacogenomics.org)

Ethanol metabolism can drastically change the NADH/NAD + ratio, providing an example of a metabolic factor that controls gene transcription and thus may influence gene silencing or activation, leading to diseased phenotype. (nih.gov)
The linkage and association of the gene encoding upstream stimulatory factor 1 with type 2 diabetes and metabolic syndrome in the Chinese population. (uchicago.edu)

From the single-cell transcriptomic data a Bayesian algorithm generated a unified lineage tree, and predicted novel regulatory transcription factors. (uth.edu)

Simple metabolites dictate the actions of specific transcription factors that sense the minute-to-minute cellular environment to determine which parts of, and the extent to which, the genetic code will be transcribed. (nih.gov)

8. Genomic profiling of the transcription factor Zfp148 and its impact on the p53 pathway. (nih.gov)

Description: A sandwich quantitative ELISA assay kit for detection of Human Fibroblast Growth Factor 23 (FGF23) in samples from serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. (hiv-pharmacogenomics.org)

This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. (nih.gov)

HN - 2019 MH - Afatinib UI - D000077716 MN - D2.65.132 MN - D3.633.100.786.188 MS - A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER. (nih.gov)
PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity. (cdc.gov)

Single-nucleotide polymorphisms in the ARNTL, ARNTL2, CLOCK and NPAS2 genes were genotyped in 511 individuals. (nih.gov)

ARNTL and NPAS2 gene variants were associated with reproduction and with seasonal variation. (nih.gov)
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. (nih.gov)

In this study, we aimed to investigate the prevalence and details of OBR and its association with clinical outcomes in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) treated with osimertinib. (bvsalud.org)
HN - 2019 MH - Afatinib UI - D000077716 MN - D2.65.132 MN - D3.633.100.786.188 MS - A quinazoline and butenamide derivative that acts as a tyrosine kinase inhibitor of epidermal growth factor receptors (ERBB RECEPTORS) and is used in the treatment of metastatic NON-SMALL CELL LUNG CANCER. (nih.gov)

Activates transcription as a heterodimer with E proteins. (nih.gov)

Anatomy7

Organisms6

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Phenomena and Processes48

Information Science3

PER and TIM inhibit the DNA binding activity of a Drosophila CLOCK-CYC/dBMAL1 heterodimer without disrupting formation of the heterodimer: a basis for circadian transcription. (1/398)

mCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop. (2/398)

Requirement of circadian genes for cocaine sensitization in Drosophila. (3/398)

Light-independent role of CRY1 and CRY2 in the mammalian circadian clock. (4/398)

Cycling vrille expression is required for a functional Drosophila clock. (5/398)

ARNT2 acts as the dimerization partner of SIM1 for the development of the hypothalamus. (6/398)

dCLOCK is present in limiting amounts and likely mediates daily interactions between the dCLOCK-CYC transcription factor and the PER-TIM complex. (7/398)

Asynchronous oscillations of two zebrafish CLOCK partners reveal differential clock control and function. (8/398)

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ARNTL Transcription Factors

Transcription Factors

Transcription, Genetic

Basic Helix-Loop-Helix Transcription Factors

Circadian Rhythm

CLOCK Proteins

Promoter Regions, Genetic

DNA-Binding Proteins

Sp1 Transcription Factor

Period Circadian Proteins

Gene Expression Regulation

Molecular Sequence Data

Base Sequence

Transcriptional Activation

Binding Sites

Trans-Activators

RNA, Messenger

Protein Binding

Nuclear Proteins

Transcription Factor AP-1

Repressor Proteins

Cell Line

Forkhead Transcription Factors

Homeodomain Proteins

Gene Expression Regulation, Developmental

Signal Transduction

Amino Acid Sequence

DNA

Basic-Leucine Zipper Transcription Factors

Transcription Factor AP-2

Mutation

Cell Nucleus

Cell Differentiation

Transfection

Kruppel-Like Transcription Factors

Transcription Factors, TFII

Chromatin Immunoprecipitation

Genes, Reporter

YY1 Transcription Factor

HeLa Cells

STAT3 Transcription Factor

GATA4 Transcription Factor

Transcription Factor TFIID

Cells, Cultured

Activating Transcription Factor 3

NFATC Transcription Factors

Sp3 Transcription Factor

Transcription Initiation Site

NF-kappa B

Reverse Transcriptase Polymerase Chain Reaction

Zinc Fingers

Paired Box Transcription Factors

Electrophoretic Mobility Shift Assay

Activating Transcription Factor 2

Transcription Factor TFIIB

Enhancer Elements, Genetic

Regulatory Sequences, Nucleic Acid

E2F1 Transcription Factor

RNA Polymerase II

Gene Expression Profiling

Cloning, Molecular

Basic Helix-Loop-Helix Leucine Zipper Transcription Factors

MEF2 Transcription Factors

Recombinant Fusion Proteins

Plasmids

GATA3 Transcription Factor

GATA1 Transcription Factor

GATA2 Transcription Factor

Gene Expression

Gene Expression Regulation, Fungal

TCF Transcription Factors

GATA Transcription Factors

Microphthalmia-Associated Transcription Factor

Luciferases

STAT1 Transcription Factor

Protein Structure, Tertiary

Activating Transcription Factors

Transcription Factor RelA

E2F Transcription Factors

Cell Line, Tumor