Armadillo domain proteins. Medical search

A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION, regulation of DESMOSOME assembly, and CELL ADHESION.

Burrowing, chiefly nocturnal mammals of the family Dasypodidae having bodies and heads encased in small bony plates. They are widely distributed in the warmer parts of the Americas.

An order of New World mammals characterized by the absence of incisors and canines from among their teeth, and comprising the ARMADILLOS, the SLOTHS, and the anteaters. The order is distinguished from all others by what are known as xenarthrous vertebrae (xenos, strange; arthron, joint): there are secondary, and sometimes even more, articulations between the vertebrae of the lumbar series. The order was formerly called Edentata. (From Random House Unabridged Dictionary, 2d ed; Walker's Mammals of the World, 5th ed, vol. I, p515)

A proto-oncogene protein and member of the Wnt family of proteins. It is expressed in the caudal MIDBRAIN and is essential for proper development of the entire mid-/hindbrain region.

Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.

A large class of structurally-related proteins that contain one or more LIM zinc finger domains. Many of the proteins in this class are involved in intracellular signaling processes and mediate their effects via LIM domain protein-protein interactions. The name LIM is derived from the first three proteins in which the motif was found: LIN-11, Isl1 and Mec-3.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.

A species of gram-positive, aerobic bacteria that causes LEPROSY in man. Its organisms are generally arranged in clumps, rounded masses, or in groups of bacilli side by side.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Major constituent of the cytoskeleton found in the cytoplasm of eukaryotic cells. They form a flexible framework for the cell, provide attachment points for organelles and formed bodies, and make communication between parts of the cell possible.

Members of the armadillo family of proteins that are found in DESMOSOMES and interact with various proteins including desmocadherins; DESMOPLAKIN; ACTIN FILAMENTS; and KERATINS.

A multi-functional catenin that is highly homologous to BETA CATENIN. Gamma catenin binds CADHERINS and helps link their cytoplasmic tails to ACTIN in the CYTOSKELETON via ALPHA CATENIN. It is also found in DESMOSOMES where it mediates the link between DESMOSOMAL CADHERINS and DESMOPLAKIN.

A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Proteins found in any species of insect.

A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

A family of cytoskeletal proteins that play essential roles in CELL ADHESION at ADHERENS JUNCTIONS by linking CADHERINS to the ACTIN FILAMENTS of the CYTOSKELETON.

Desmoplakins are cytoskeletal linker proteins that anchor INTERMEDIATE FILAMENTS to the PLASMA MEMBRANE at DESMOSOMES.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Transport proteins that carry specific substances in the blood or across cell membranes.

Screening techniques first developed in yeast to identify genes encoding interacting proteins. Variations are used to evaluate interplay between proteins and other molecules. Two-hybrid techniques refer to analysis for protein-protein interactions, one-hybrid for DNA-protein interactions, three-hybrid interactions for RNA-protein interactions or ligand-based interactions. Reverse n-hybrid techniques refer to analysis for mutations or other small molecules that dissociate known interactions.

A superfamily of proteins that share a highly conserved MADS domain sequence motif. The term MADS refers to the first four members which were MCM1 PROTEIN; AGAMOUS 1 PROTEIN; DEFICIENS PROTEIN; and SERUM RESPONSE FACTOR. Many MADS domain proteins have been found in species from all eukaryotic kingdoms. They play an important role in development, especially in plants where they have an important role in flower development.

A multi-functional catenin that participates in CELL ADHESION and nuclear signaling. Beta catenin binds CADHERINS and helps link their cytoplasmic tails to the ACTIN in the CYTOSKELETON via ALPHA CATENIN. It also serves as a transcriptional co-activator and downstream component of WNT PROTEIN-mediated SIGNAL TRANSDUCTION PATHWAYS.

Regions of AMINO ACID SEQUENCE similarity in the SRC-FAMILY TYROSINE KINASES that fold into specific functional tertiary structures. The SH1 domain is a CATALYTIC DOMAIN. SH2 and SH3 domains are protein interaction domains. SH2 usually binds PHOSPHOTYROSINE-containing proteins and SH3 interacts with CYTOSKELETAL PROTEINS.

Protein modules with conserved ligand-binding surfaces which mediate specific interaction functions in SIGNAL TRANSDUCTION PATHWAYS and the specific BINDING SITES of their cognate protein LIGANDS.

Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.

A chronic granulomatous infection caused by MYCOBACTERIUM LEPRAE. The granulomatous lesions are manifested in the skin, the mucous membranes, and the peripheral nerves. Two polar or principal types are lepromatous and tuberculoid.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Protein interaction domains of about 70-90 amino acid residues, named after a common structure found in PSD-95, Discs Large, and Zona Occludens 1 proteins. PDZ domains are involved in the recruitment and interaction of proteins, and aid the formation of protein scaffolds and signaling networks. This is achieved by sequence-specific binding between a PDZ domain in one protein and a PDZ motif in another protein.

A catenin that binds F-ACTIN and links the CYTOSKELETON with BETA CATENIN and GAMMA CATENIN.

Proteins prepared by recombinant DNA technology.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

Calcium-dependent cell adhesion proteins. They are important in the formation of ADHERENS JUNCTIONS between cells. Cadherins are classified by their distinct immunological and tissue specificities, either by letters (E- for epithelial, N- for neural, and P- for placental cadherins) or by numbers (cadherin-12 or N-cadherin 2 for brain-cadherin). Cadherins promote cell adhesion via a homophilic mechanism as in the construction of tissues and of the whole animal body.

The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.

A species of fruit fly much used in genetics because of the large size of its chromosomes.

Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.

An enzyme that catalyzes the degradation of GLYCOGEN in animals by releasing glucose-1-phosphate from the terminal alpha-1,4-glycosidic bond. This enzyme exists in two forms: an active phosphorylated form ( PHOSPHORYLASE A) and an inactive un-phosphorylated form (PHOSPHORYLASE B). Both a and b forms of phosphorylase exist as homodimers. In mammals, the major isozymes of glycogen phosphorylase are found in muscle, liver and brain tissue.

An isoenzyme of GLYCOGEN PHOSPHORYLASE that catalyzes the degradation of GLYCOGEN in liver tissue. Mutation of the gene coding this enzyme on chromosome 14 is the cause of GLYCOGEN STORAGE DISEASE TYPE VI.

An enzyme that catalyzes the transfer of ribose from uridine to orthophosphate, forming uracil and ribose 1-phosphate.

Five-carbon furanose sugars in which the OXYGEN is replaced by a NITROGEN atom.

A class of glucosyltransferases that catalyzes the degradation of storage polysaccharides, such as glucose polymers, by phosphorolysis in animals (GLYCOGEN PHOSPHORYLASE) and in plants (STARCH PHOSPHORYLASE).

Sequential operating programs and data which instruct the functioning of a digital computer.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. (1/286)

Drosophila Armadillo and its vertebrate homolog beta-catenin are key effectors of Wingless/Wnt signaling. In the current model, Wingless/Wnt signal stabilizes Armadillo/beta-catenin, which then accumulates in nuclei and binds TCF/LEF family proteins, forming bipartite transcription factors which activate transcription of Wingless/Wnt responsive genes. This model was recently challenged. Overexpression in Xenopus of membrane-tethered beta-catenin or its paralog plakoglobin activates Wnt signaling, suggesting that nuclear localization of Armadillo/beta-catenin is not essential for signaling. Tethered plakoglobin or beta-catenin might signal on their own or might act indirectly by elevating levels of endogenous beta-catenin. We tested these hypotheses in Drosophila by removing endogenous Armadillo. We generated a series of mutant Armadillo proteins with altered intracellular localizations, and expressed these in wild-type and armadillo mutant backgrounds. We found that membrane-tethered Armadillo cannot signal on its own; however it can function in adherens junctions. We also created mutant forms of Armadillo carrying heterologous nuclear localization or nuclear export signals. Although these signals alter the subcellular localization of Arm when overexpressed in Xenopus, in Drosophila they have little effect on localization and only subtle effects on signaling. This supports a model in which Armadillo's nuclear localization is key for signaling, but in which Armadillo intracellular localization is controlled by the availability and affinity of its binding partners. (+info)

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. (2/286)

Wnt/Wingless directs many cell fates during development. Wnt/Wingless signaling increases the amount of beta-catenin/Armadillo, which in turn activates gene transcription. Here the Drosophila protein D-Axin was shown to interact with Armadillo and D-APC. Mutation of d-axin resulted in the accumulation of cytoplasmic Armadillo and one of the Wingless target gene products, Distal-less. Ectopic expression of d-axin inhibited Wingless signaling. Hence, D-Axin negatively regulates Wingless signaling by down-regulating the level of Armadillo. These results establish the importance of the Axin family of proteins in Wnt/Wingless signaling in Drosophila. (+info)

The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling. (3/286)

The Drosophila cubitus interruptus (ci) gene encodes a sequence-specific DNA-binding protein that regulates transcription of Hedgehog (Hh) target genes. Activity of the Ci protein is posttranslationally regulated by Hh signaling. In animals homozygous for the ciD mutation, however, transcription of Hh target genes is regulated by Wingless (Wg) signaling rather than by Hh signaling. We show that ciD encodes a chimeric protein composed of the regulatory domain of dTCF/Pangolin (Pan) and the DNA binding domain of Ci. Pan is a Wg-regulated transcription factor that is activated by binding of Armadillo (Arm) to its regulatory domain. Arm is thought to activate Pan by contributing a transactivation domain. We find that a constitutively active form of Arm potentiates activity of a CiD transgene and coimmunoprecipitates with CiD protein. The Wg-responsive activity of CiD could be explained by recruitment of the Arm transactivation function to the promoters of Hh-target genes. We suggest that wild-type Ci also recruits a protein with a transactivation domain as part of its normal mechanism of activation. (+info)

The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila. (4/286)

Wnt signalling is a key pathway for tissue patterning during animal development. In Drosophila, the Wnt protein Wingless acts to stabilize Armadillo inside cells where it binds to at least two DNA-binding factors which regulate specific target genes. One Armadillo-binding protein in Drosophila is the zinc finger protein Teashirt. Here we show that Wingless signalling promotes the phosphorylation and the nuclear accumulation of Teashirt. This process requires the binding of Teashirt to the C-terminal end of Armadillo. Finally, we present evidence that the serine/threonine kinase Shaggy is associated with Teashirt in a complex. We discuss these results with respect to current models of Armadillo/beta-catenin action for the transmission of the Wingless/Wnt pathway. (+info)

Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro. (5/286)

beta-Catenin, a member of the family of Armadillo repeat proteins, plays a dual role in cadherin-mediated cell adhesion and in signaling by Wnt growth factors. Upon Wnt stimulation beta-catenin undergoes nuclear translocation and serves as transcriptional coactivator of T cell factor DNA-binding proteins. Previously the transactivation potential of different portions of beta-catenin has been demonstrated, but the precise location of transactivating elements has not been established. Also, the mechanism of transactivation by beta-catenin and the molecular basis for functional differences between beta-catenin and the closely related proteins Armadillo and Plakoglobin are poorly understood. Here we have used a yeast system for the detailed characterization of the transactivation properties of beta-catenin. We show that its transactivation domains possess a modular structure, consist of multiple subelements that cover broad regions at its N and C termini, and extend considerably into the Armadillo repeat region. Compared with beta-catenin the N termini of Plakoglobin and Armadillo have different transactivation capacities that may explain their distinct signaling properties. Furthermore, transactivating elements of beta-catenin interact specifically and directly with the TATA-binding protein in vitro providing further evidence that a major function of beta-catenin during Wnt signaling is to recruit the basal transcription machinery to promoter regions of Wnt target genes. (+info)

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. (6/286)

The vertebrate Axin protein, the product of the mouse fused gene, binds to beta-catenin to inhibit Wnt signaling. We have identified a homolog of Axin in Drosophila, Daxin. Using double-stranded RNA interference, we generated loss-of-function phenotypes that are similar to overexpression of the Drosophila Wnt gene wingless (wg). Overexpression of Daxin produces phenotypes similar to loss of wg. In addition, we show that Daxin overexpression can modify phenotypes elicited by wg and another Drosophila Wnt gene, DWnt-2. Using immunoprecipitation of endogenous Daxin protein from embryos we show that Daxin interacts with Armadillo and Zeste-white 3. The loss-of-function and overexpression phenotypes show that Daxin, like its mammalian counterpart, acts as a negative regulator of wg/Wnt signaling. (+info)

Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. (7/286)

In cell culture assays, Frizzled and Dfrizzled2, two members of the Frizzled family of integral membrane proteins, are able to bind Wingless and transduce the Wingless signal. To address the role of these proteins in the intact organism and to explore the question of specificity of ligand-receptor interactions in vivo, we have conducted a genetic analysis of frizzled and Dfrizzled2 in the embryo. These experiments utilize a small gamma-ray-induced deficiency that uncovers Dfrizzled2. Mutants lacking maternal frizzled and zygotic frizzled and Dfrizzled2 exhibit defects in the embryonic epidermis, CNS, heart and midgut that are indistinguishable from those observed in wingless mutants. Epidermal patterning defects in the frizzled, Dfrizzled2 double-mutant embryos can be rescued by ectopic expression of either gene. In frizzled, Dfrizzled2 mutant embryos, ectopic production of Wingless does not detectably alter the epidermal patterning defect, but ectopic production of an activated form of Armadillo produces a naked cuticle phenotype indistinguishable from that produced by ectopic production of activated Armadillo in wild-type embryos. These experiments indicate that frizzled and Dfrizzled2 function downstream of wingless and upstream of armadillo, consistent with their proposed roles as Wingless receptors. The lack of an effect on epidermal patterning of ectopic Wingless in a frizzled, Dfrizzled2 double mutant argues against the existence of additional Wingless receptors in the embryo or a model in which Frizzled and Dfrizzled2 act simply to present the ligand to its bona fide receptor. These data lead to the conclusion that Frizzled and Dfrizzled2 function as redundant Wingless receptors in multiple embryonic tissues and that this role is accurately reflected in tissue culture experiments. The redundancy of Frizzled and Dfrizzled2 explains why Wingless receptors were not identified in earlier genetic screens for mutants defective in embryonic patterning. (+info)

Roles of the C terminus of Armadillo in Wingless signaling in Drosophila. (8/286)

Drosophila melanogaster Armadillo and its vertebrate homolog beta-catenin play multiple roles during development. Both are components of cell-cell adherens junctions and both transduce Wingless (Wg)/Wnt intercellular signals. The current model for Wingless signaling proposes that Armadillo binds the DNA-binding protein dTCF, forming a bipartite transcription factor that activates Wingless-responsive genes. In this model, Armadillo's C-terminal domain is proposed to serve an essential role as a transcriptional activation domain. In Xenopus, however, overexpression of C-terminally truncated beta-catenin activates Wnt signaling, suggesting that the C-terminal domain might not be essential. We reexamined the function of Armadillo's C terminus in Wingless signaling. We found that C-terminally truncated mutant Armadillo has a deficit in Wg-signaling activity, even when corrected for reduced protein levels. However, we also found that Armadillo proteins lacking all or part of the C terminus retain some signaling ability if overexpressed, and that mutants lacking different portions of the C-terminal domain differ in their level of signaling ability. Finally, we found that the C terminus plays a role in Armadillo protein stability in response to Wingless signal and that the C-terminal domain can physically interact with the Arm repeat region. These data suggest that the C-terminal domain plays a complex role in Wingless signaling and that Armadillo recruits the transcriptional machinery via multiple contact sites, which act in an additive fashion. (+info)

Leprosy can cause a range of symptoms, including:

1. Skin lesions: Leprosy can cause skin lesions, including lighter or darker patches on the skin, and thickening of the skin.
2. Nerve damage: The bacteria can damage the nerves, leading to numbness, pain, and muscle weakness.
3. Eye problems: Leprosy can cause eye inflammation, vision loss, and dryness of the eyes.
4. Respiratory problems: In severe cases, leprosy can cause breathing difficulties and respiratory failure.
5. Enlarged lymph nodes: The lymph nodes may become enlarged in some cases.
6. Joint pain and swelling: Leprosy can cause joint pain and swelling.
7. Neuritis: Inflammation of the nerves can occur, leading to pain, numbness, and tingling sensations.
8. Ulcers: Leprosy can cause ulcers on the skin and mucous membranes.

Leprosy is diagnosed through a combination of physical examination, laboratory tests, and medical imaging. Treatment typically involves a combination of antibiotics and other medications to manage symptoms. In some cases, surgery may be necessary to remove infected tissue or repair damaged nerves.

Leprosy can be transmitted through respiratory droplets, close contact with an infected person, or through contaminated objects such as clothing or bedding. However, leprosy is not highly contagious and the risk of transmission is low if proper precautions are taken.

While there is no cure for leprosy, early diagnosis and treatment can prevent complications and disability. However, due to the stigma surrounding the disease, many people may delay seeking medical attention, leading to a higher risk of long-term complications.

Overall, while leprosy is a serious disease, it is also a preventable and treatable one. With proper awareness and education, we can work towards reducing the stigma surrounding leprosy and ensuring that those affected receive the medical attention they need.

... armadillo (ARM) GUK and LIM domains, which mediate specific protein-protein binding. The literature-based adhesome contains ... Protein domains enriched in the adhesome include: Pleckstrin homology (PH) and FERM domains, which target proteins to the ... examined the effect of inhibition of myosin contractility on the integrin adhesome composition and found LIM domain proteins ... The adhesome contains multi domain proteins with various functions, some of which are specifically enriched in the adhesome ...

https://en.wikipedia.org/wiki/Adhesome

Plakophilin proteins contain nine central, conserved armadillo repeat domains flanked by N-terminal and C-terminal domains. ... "Protein sequence of human PKP2 (Uniprot ID: Q99959-2)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Retrieved 11 ... Plakophilin-2 is a member of the armadillo repeat and plakophilin protein family. ... and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". ...

https://en.wikipedia.org/wiki/Plakophilin-2

The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo repeats. Other proteins containing ... Armadillo repeat-containing X-linked protein 1 is a protein that in humans is encoded by the ARMCX1 gene. This gene encodes a ... Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed ... "Entrez Gene: ARMCX1 armadillo repeat containing, X-linked 1". Human ARMCX1 genome location and ARMCX1 gene details page in the ...

https://en.wikipedia.org/wiki/ARMCX1

The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo repeat. Other proteins ... Armadillo repeat-containing X-linked protein 3 is a protein that in humans is encoded by the ARMCX3 gene. This gene encodes a ... Kurochkin IV, Yonemitsu N, Funahashi SI, Nomura H (Feb 2001). "ALEX1, a novel human armadillo repeat protein that is expressed ... Mou Z, Tapper AR, Gardner PD (May 2009). "The Armadillo Repeat-containing Protein, ARMCX3, Physically and Functionally ...

https://en.wikipedia.org/wiki/ARMCX3

But, the armadillo repeat is found in a wide range of proteins with other functions. This type of protein domain is important ... 4 Armadillo+Domain+Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) Armadillo/plakoglobin ARM ... Proteins that contain armadillo repeats typically contain several tandemly repeated copies. Each armadillo repeat is composed ... Examples of proteins that contain armadillo repeats include β-catenin, α-importin, plakoglobin, adenomatous polyposis coli (APC ...

https://en.wikipedia.org/wiki/Armadillo_repeat

... rigid protein domain with an elongated shape - called armadillo (ARM) domain. An average armadillo repeat is composed of three ... DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ... In Drosophila, the homologous protein is called armadillo. β-catenin is a subunit of the cadherin protein complex and acts as ... The first helices of the ARM domain form an additional, special protein-protein interaction pocket: This can accommodate a ...

https://en.wikipedia.org/wiki/Catenin_beta-1

A fifth TIR-domain-containing adaptor protein called Sterile α and HEAT (Armadillo motif) (SARM) is a TLR4 signaling pathway ... This TRIF-dependent pathway involves the recruitment of the adaptor proteins TIR-domain-containing adaptor inducing interferon- ... Toll-like receptor 4 is a protein that in humans is encoded by the TLR4 gene. TLR4 is a transmembrane protein, member of the ... Morphine causes inflammation by binding to the protein lymphocyte antigen 96, which, in turn, causes the protein to bind to ...

https://en.wikipedia.org/wiki/Toll-like_receptor_4

... rho GTPase activating protein 21 ARID5B: encoding protein AT-rich interactive domain-containing protein 5B ARMH3: Armadillo ... encoding protein Transmembrane protein 26 TMEM72: encoding protein Transmembrane protein 72 TYSND1: encoding protein Trypsin ... WW domain binding protein 1-like ZNF37A: zinc finger protein 37A ZNF438: zinc finger protein 438 ZRANB1: Zinc finger ranbp2- ... plexin domain-containing protein 2 PRAP1: encoding protein Proline rich acidic protein 1 PROSER2: proline and serine rich 2 or ...

https://en.wikipedia.org/wiki/Chromosome_10

... encoding protein Ankyrin repeat domain-containing protein 24 ARMC6: encoding protein Armadillo repeat-containing protein 6 ... encoding protein Transmembrane Protein 205 UBXN6: encoding protein UBX domain protein 6 UCA1: a long non-coding RNA Urothelial ... encoding protein Transmembrane emp24 domain-containing protein 1 TMEM160: encoding protein Transmembrane protein 160 TMEM205: ... encoding protein Zinc finger protein 112 ZNF134: encoding protein Zinc finger protein 134 ZNF160: encoding protein Zinc finger ...

https://en.wikipedia.org/wiki/Chromosome_19

Several protein domains also form tandem repeats within their amino acid primary structure, such as armadillo repeats. However ... in proteins, perfect tandem repeats are unlikely in most in vivo proteins, and most known repeats are in proteins which have ... "Protein tandem repeats - the more perfect, the less structured". The FEBS Journal. 277 (12): 2673-82. doi:10.1111/j.1742- ... A combined method for the identification of tandem repeats in protein structures Tandem Repeats Finder Mreps STAR Splinter TRED ...

https://en.wikipedia.org/wiki/Tandem_repeat

Armadillo repeats: named after the β-catenin-like Armadillo protein of the fruit fly Drosophila melanogaster. Basic leucine ... a biological database covering protein domains Pfam: database of protein domains Protein Protein structure Protein structure ... Protein domains, connected by intrinsically disordered flexible linker domains, induce long-range allostery via protein domain ... multi-domain proteins. Many domains in eukaryotic multidomain proteins can be found as independent proteins in prokaryotes, ...

https://en.wikipedia.org/wiki/Protein_domain

... armadillo repeats, tetratricopeptide repeats, etc. Whenever a linear solenoid domain structure participates in protein-protein ... Solenoid protein domains are a highly modular type of protein domain. They consist of a chain of nearly identical folds, often ... While individual BRCT domains are found in certain proteins (e.g. some DNA ligases) binding DNA, these tandem BRCT domains ... Proteins that contain tandem repeats of ordinary domains are very common in eukaryotes. Even if these domains are perfectly ...

https://en.wikipedia.org/wiki/Solenoid_protein_domain

Evidence of two reserved ARM superfamily domains are shown in the TMCO6 protein. The ARM domain, Armadillo/ beta-catenin-like- ... "Transmembrane And Coiled-Coil Domain 6". GeneCards. "transmembrane and coiled-coil domain-containing protein 6 isoform 1 H - ... Function of the conserved ARM domain and SRP1 domains are known. The ARM domains play a role in mediating the interaction of ... Transmembrane and coiled-coil domain-containing protein". Protein - NCBI. Behnke J, Eskelinen EL, Saftig P, Schröder B (Mar ...

https://en.wikipedia.org/wiki/TMCO6

... or Armadillo Like Helical Domain Containing 3, also known as UPF0668 and c10orf76, is a protein that in humans is encoded ... These domains have been shown to participate in protein-protein binding interactions, specifically via the SH3 protein binding ... NCBI identifies a protein domain of unknown function between amino acids Asp435 and Leu671, known as DUF1741 (Domain of Unknown ... The locus is alternatively spliced and predicted to yield five protein variants, three of which contain a protein domain of ...

https://en.wikipedia.org/wiki/ARMH3

... gene encodes a protein containing two motifs, a coiled coil domain in the N-terminus and a 10 armadillo repeat sequence ... Armadillo repeat protein deleted in velo-cardio-facial syndrome is a protein that in humans is encoded by the ARVCF gene. ... Since these sequences can facilitate protein-protein interactions ARVCF is thought to function in a protein complex. In ... Binding to PDZ-Domain Proteins and Cell-Cell Adhesion Regulate Plasma Membrane and Nuclear Localization of ARVCF". Mol Biol ...

https://en.wikipedia.org/wiki/ARVCF

... is a small protein consisting of three functionally distinct domains: the IBB domain, ARM domain, and exportin CAS ... and the targeted protein. The majority of the importin α protein is made up of a series of ten tandem armadillo, or ARM, ... The N-terminal region of the proteins consists of an importin-β-binding, or IBB, domain. This region of the protein is ... NLS binding to the ARM domain, and thereby the formation of the import complex, is regulated by the IBB domain of importin α. ...

https://en.wikipedia.org/wiki/Importin_α

... domain, a kinase domain, a RAS domain, a GTPase domain, and a WD40 domain. The protein is present largely in the cytoplasm but ... The LRRK2 gene encodes a protein with an armadillo repeats (ARM) region, an ankyrin repeat (ANK) region, a leucine-rich repeat ... Mata IF, Wedemeyer WJ, Farrer MJ, Taylor JP, Gallo KA (May 2006). "LRRK2 in Parkinson's disease: protein domains and functional ... LRRK2 interacts with the C-terminal R2 RING finger domain of parkin, and parkin interacted with the COR domain of LRRK2. ...

https://en.wikipedia.org/wiki/LRRK2

... of the luminal domain and the transmembrane domain near the C-terminus. This effectively abrogates its function as a protein ... A similar variant is also reported in armadillo. So this is not a random mutation. The function of this truncated protein is ... The protein contains two hydrophobic transmembrane domains that help anchoring the molecule on the ER membrane, such that its ... It encodes a protein of 377 amino acid residues. ERGIC2 protein is also known as PTX1, CDA14 or Erv41. The biological function ...

https://en.wikipedia.org/wiki/ERGIC2

Domain, Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ ... Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene. This gene is a ... 1996). "Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic ... Zinc finger and BTB domain-containing protein 16 has been shown to interact with: Angiotensin II receptor type 1, BCL6, BMI1, ...

https://en.wikipedia.org/wiki/Zinc_finger_and_BTB_domain-containing_protein_16

"Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis". Nature. 394 (6695): 793-7. Bibcode: ... Structurally Similar to Armadillo and Heat Repeats, Interacts with the Transcription Factor Promyelocytic Leukemia Zn2+ Finger ... Epsin-1 is a protein that in humans is encoded by the EPN1 gene. EPN1 is an endocytic accessory protein that interacts with ... Morinaka K, Koyama S, Nakashima S, Hinoi T, Okawa K, Iwamatsu A, Kikuchi A (Dec 1999). "Epsin binds to the EH domain of POB1 ...

https://en.wikipedia.org/wiki/EPN1

In addition, the encoded protein contains Armadillo/beta-catenin-like repeats, which have been implicated in protein-protein ... 2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple ... Beta-catenin-like protein 1 is a protein that in humans is encoded by the CTNNBL1 gene. The protein encoded by this gene ... Although the function of this protein has not been determined, the C-terminal portion of the protein has been shown to possess ...

https://en.wikipedia.org/wiki/CTNNBL1

The SARM1 protein has a mitochondrial localization signal, an auto-inhibitory N-terminus region consisting of armadillo (ARM)/ ... Essuman K, Summers DW, Sasaki Y, Mao X, Yim AK, DiAntonio A, Milbrandt J (February 2018). "TIR Domain Proteins Are an Ancient ... that bind to SARM1's allosteric ARM domain region and activate its TIR domain NADase activity. When NAD+ levels are low, ... SARM1's TIR domain is a multi-functional NAD(P)ase enzyme capable of hydrolyzing NAD+ or NADP, cyclizing NAD+ or NADP to form ...

https://en.wikipedia.org/wiki/SARM1

The SARM1 protein has four domains, a mitochondrial localization signal, an auto-inhibitory N-terminus region consisting of ... armadillo/HEAT motifs, two sterile alpha motifs responsible for multimerization, and a C-terminus Toll/Interleukin-1 receptor ... Although the protein created localizes within the nucleus and is barely detectable in axons, studies suggest that its ... The protective effect of the WldS protein has been shown to be due to the NMNAT1 region's NAD+ synthesizing active site. ...

https://en.wikipedia.org/wiki/Wallerian_degeneration

The protein contains the following three domains: N-terminal Armadillo domain (residues 82-262) central ELMO (Engulfment and ... The structure of the pleckstrin homology domain of ELMO1 has been determine by X-ray crystallography. The protein encoded by ... 2002). "Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP ... Engulfment and cell motility protein 1 is a protein that in humans is encoded by the ELMO1 gene. ELMO1 is located on chromosome ...

https://en.wikipedia.org/wiki/ELMO1

PDZ domain-containing protein 2 is a protein that in humans is encoded by the PDZD2 gene. Proteins containing PDZ domains have ... A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin ... A novel multiple PSD-95/Dlg-A/ZO-1 protein interacting with neural plakophilin-related armadillo repeat protein/delta-catenin ... Nakayama M, Kikuno R, Ohara O (2002). "Protein-protein interactions between large proteins: two-hybrid screening using a ...

https://en.wikipedia.org/wiki/PDZD2

Like other NBPF proteins, the NBPF1 protein product contains a repeated domain called DUF1220, a domain of unknown function ... Additionally, it contains amino acid repeats that are present in humans, other primates, and even armadillos. Another feature ... The two most important domain types in the NBPF1 protein are the coiled coil domains and DUF1220 domains. NBPF1 contains three ... This protein is member of the neuroblastoma breakpoint family of proteins, a group of proteins that are thought to be involved ...

https://en.wikipedia.org/wiki/NBPF1

Zhou Z, Caron E, Hartwieg E, Hall A, Horvitz HR (October 2001). "The C. elegans PH domain protein CED-12 regulates cytoskeletal ... All isoforms contain a series of armadillo repeats, which begin at the N-terminus and extend around two thirds of the way along ... the protein, as well as a C-terminal proline-rich motif and a central PH domain. They function as part of a protein complex ... In humans there are three paralogous isoforms: ELMO1 ELMO2 ELMO3 The ELMO domain was first characterized in the CED-12 proteins ...

https://en.wikipedia.org/wiki/ELMO_(protein)

... including the actin-binding protein profilin, SH3 (Src homology 3) domain proteins, and WW domain proteins. The actin ... Another commonly found domain is an armadillo repeat region (ARR) located in the FH3 domain. The FH2 domain, has been shown by ... Protein pages needing a picture, Genes on human chromosome 15, Protein domains, Cell biology, Proteins, Cellular processes). ... The FH2 domain is required for the self-association of formin proteins through the ability of FH2 domains to directly bind each ...

https://en.wikipedia.org/wiki/Formins

... encoding protein FERM and PDZ domain containing 4 FUNDC1: encoding protein FUN14 domain containing 1 FUNDC2: FUN14 domain- ... encoding protein Armadillo repeat containing X-linked 6 BEX1: encoding protein Brain-expressed X-linked protein 1 BEX2: ... encoding protein V-set and immunoglobulin domain containing 1 YIPF6: encoding protein Protein YIPF6 ZC3H12B: encoding protein ... encoding protein Coiled coil domain containing protein 120 CCDC22: encoding protein Coiled-coil domain containing 22 CD99L2: ...

https://en.wikipedia.org/wiki/X_chromosome

Armadillo proteins are involved in mediating attachment to intracellular filaments and cell membrane proteins. Armadillo ... which are in the cadherin family of cell adhesion proteins. Both have five extracellular domains, and have calcium-binding ... and the armadillo family of mediatory proteins plakoglobin and plakophilin. ... Desmoplakin has two isoforms that differ in the length of their middle rod domain. All desmoplakins have an N-terminal head, a ...

https://en.wikipedia.org/wiki/Desmosome

α-catenin β-catenin γ-catenin δ-catenin All but α-catenin contain armadillo repeats. They exhibit a high degree of protein ... "The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related ... First of all, by binding to cadherin receptor intracellular cytoplasmic tail domains, it can act as an integral component of a ... Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two ...

https://en.wikipedia.org/wiki/Catenin

v t e (CS1: long volume value, Genes on human chromosome 1, Armadillo-repeat-containing proteins, All stub articles, Protein ... Choi HJ, Weis WI (2005). "Structure of the armadillo repeat domain of plakophilin 1". J. Mol. Biol. 346 (1): 367-76. doi: ... Plakophilin-1 is a protein that in humans is encoded by the PKP1 gene. This gene encodes a member of the arm-repeat (armadillo ... Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking ...

https://en.wikipedia.org/wiki/Plakophilin-1

Archaeology: Astolfo Gomes de Mello Araujo and Jose Carlos Marcelino, for showing that armadillos can mix up the contents of an ... Ig Nobel Prize Winner List (public domain) Gold, Jon (13 September 2013). "2013 Ig Nobel Prize winners: from opera-loving mice ... "Shear-Stress-Mediated Refolding of Proteins from Aggregates and Inclusion Bodies". ChemBioChem. 16 (3): 393-396. doi:10.1002/ ... Araujo, A. G. M.; Marcelino, J. C. (2003). "The role of armadillos in the movement of archaeological materials: an experimental ...

https://en.wikipedia.org/wiki/List_of_Ig_Nobel_Prize_winners

This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. ... Ohkubo T, Ozawa M (July 1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is ... The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 4 (2): 141-50. ... Ohkubo T, Ozawa M (1999). "p120(ctn) binds to the membrane-proximal region of the E-cadherin cytoplasmic domain and is involved ...

https://en.wikipedia.org/wiki/P120_(protein)

The NRDE (DUF883) domain, is a domain of unknown function spanning majority of the C22orf25 gene and is found among distantly ... C22orf25 is in close proximity to DGCR8 as well as other genes known to play a part in DiGeorge Syndrome such as armadillo ... C22orf25 is also xenologous to T10 like proteins in the Fowlpox Virus and Canarypox Virus. The gene coding for C22orf25 is ... This domain is found among distantly related species from the six kingdoms: Eubacteria, Archaebacteria, Protista, Fungi, ...

https://en.wikipedia.org/wiki/TANGO2

"The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1". Protein Sci. 15 (6): 1500-5. ... "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family". J Biol Chem. 271 (28): 16712-9. ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Protein tyrosine phosphatases ... reporter gene with a signal sequence and the transmembrane domain of the type I transmembrane protein CD4. If the transgene was ...

https://en.wikipedia.org/wiki/PTPRK

2007). "RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8alpha and ARMC8beta are components of the ... "Molecular analysis of muskelin identifies a conserved discoidin-like domain that contributes to protein self-association". ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... Muskelin is a protein that in humans is encoded by the MKLN1 gene. MKLN1 has been shown to interact with RANBP9. GRCh38: ...

https://en.wikipedia.org/wiki/Muskelin

... it has now been shown that the protein has numerous phosphorylation sites both N- and C-term of this domain, and that protein ... "Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses". J. Biol. Chem. United ... "The AAA+ protein torsinA interacts with a conserved domain present in LAP1 and a novel ER protein". J. Cell Biol. 168 (6): 855- ... portray Densin-180 as a key interactor in the midst of receptor proteins, scaffolding proteins and structural proteins. [number ...

https://en.wikipedia.org/wiki/LRRC7

... (Cell Death Abnormality Protein-12) is a cytoplasmic, PH-domain containing adaptor protein found in Caenorhabditis ... The repeating Armadillo (ARM) region on the N-terminal binds CED-2/CrkII, which is necessary to activate the heterodimerization ... The first is by CED-6, which is an adaptor protein that is responsible for coordinating protein-protein interactions between ... The protein structure of CED-12 is separated based on its binding domains: The proline-rich region on CED-12 is a binding site ...

https://en.wikipedia.org/wiki/Ced-12

... both have 12 armadillo repeats as well as N-terminal and C-terminal globular domains of unknown structure. Plakoglobin was ... "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family". The Journal of Biological ... "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family". The Journal of Biological ... "Adult mice deficient in actinin-associated LIM-domain protein reveal a developmental pathway for right ventricular ...

https://en.wikipedia.org/wiki/Plakoglobin

Hanks SK, Hunter T (May 1995). "Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain ... "Analysis of combinatorial effects of Wnts and Frizzleds on beta-catenin/armadillo stabilization and Dishevelled phosphorylation ... PER protein in this mutant is hypophosphorylated. Each of these mutations maps to the kinase domain of DBT gene. The short- and ... The family members have the highest homology in their kinase domains (53%-98% identical) and differ from most other protein ...

https://en.wikipedia.org/wiki/Casein_kinase_1

Vesicle coat proteins frequently contain alpha solenoids and share common domain architecture with some NPC proteins. Three ... and its adaptor protein importin alpha is an alpha solenoid formed from Armadillo repeats. Transporters of other molecules, ... Like beta propellers, alpha solenoids are a form of solenoid protein domain commonly found in the proteins comprising the ... The protein-protein interaction capacity of alpha solenoid proteins also makes them well suited to function as regulatory ...

https://en.wikipedia.org/wiki/Alpha_solenoid

... and is thought to mediate protein-protein interactions. Several eukaryotic genes contain ARM domains including armadillo in ... The FAM203B protein contains two conserved domains of unknown function, DUF383 and DUF384, and no transmembrane domains. This ... "Predicted: brain protein 16-like [Danio rerio]". NCBI Protein. Retrieved 5 February 2013. "Predicted: brain protein 16-like [ ... Domain of unknown function 383 Every ortholog and homolog of FAM203B has a DUF383 domain and a DUF384 domain (except Anolis ...

https://en.wikipedia.org/wiki/FAM203B

Dsh proteins are present in all organisms and they all share the following highly conserved protein domains: an amino-terminal ... "Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo". Cell. 125 (2 ... DIX domain, a central PDZ domain, and a carboxy-terminal DEP domain. These different domains are important because after Dsh, ... the activated Fz receptor directly interacts with Dsh and activates specific Dsh-protein domains. The domains involved in Wnt/ ...

https://en.wikipedia.org/wiki/Wnt_signaling_pathway

... of an N-terminal beta-trefoil domain and a C-terminal alpha helical domain with a folding pattern similar to an armadillo ... The initial sequencing was reported as an unknown protein enriched in the cerebellum called P400. The large size of this open ... Furuichi T, Yoshikawa S, Mikoshiba K (1989). "Nucleotide sequence of cDNA encoding P400 protein in the mouse cerebellum". ... Protein pages needing a picture, Genes on human chromosome 12, Genes on human chromosome 6, Signal transduction, Transmembrane ...

https://en.wikipedia.org/wiki/Inositol_trisphosphate_receptor

v t e (Genes on human chromosome 6, Armadillo-repeat-containing proteins, All stub articles, Human chromosome 6 gene stubs). ... Freed EO, Englund G, Martin MA (1995). "Role of the basic domain of human immunodeficiency virus type 1 matrix in macrophage ... KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into ... 1994). "The Vpr protein of human immunodeficiency virus type 1 influences nuclear localization of viral nucleic acids in ...

https://en.wikipedia.org/wiki/Importin_subunit_alpha-6

The nucleic acid sequence of a specific receptor-binding domain of the spike protein belonging to coronaviruses taken from ... Rose, Kd; Gaudin, Tj (2010). Xenarthra and Pholidota (Armadillos, Anteaters, Sloths and Pangolins). John Wiley & Sons, Ltd. doi ... and armadillos), but recent genetic evidence indicates their closest living relatives are the carnivorans, with which they form ... when genetic analysis showed that the spike protein and its binding to receptors in pangolins had minimal effect from the virus ...

https://en.wikipedia.org/wiki/Pangolin

The ARMC5 protein contains a N-terminal domain made of Armadillo (ARM) repeats and a C-terminal Bric-a-Brac, Tramtrack, Broad- ... Background: ARMC5 (armadillo repeat containing 5) has been identified as the gene responsible for PBMAH (Primary Bilateral ... ea0014s3.2 , Signaling and regulation of G-protein-coupled hormone receptors , ECE2007. Pharmacological chaperones rescue the ... The majority of loss-of function mutations of G protein coupled receptors, leading to diseases, such as diabetes insipidus (V2 ...

https://www.endocrine-abstracts.org/search?a=1&q=Eric%20Clauser

Armadillo Domain Proteins Entry term(s). Arm Motif Proteins Armadillo Motif Proteins Armadillo Protein Armadillo Protein Family ... Arm Motif Proteins. Armadillo Motif Proteins. Armadillo Protein. Armadillo Protein Family. Armadillo Proteins. Armadillo Repeat ... Armadillo Domain Proteins - Preferred Concept UI. M0165209. Scope note. A family of proteins that contain several 42-amino acid ... A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. ...

https://decs.bvsalud.org/en/ths/resource/?id=50820

We isolated a gene, TaPUB26, from wheat that encodes a protein containing a U-box domain and armadillo (ARM) repeats. The ... YrNAM encodes a non-canonical resistance protein with a NAM domain and a ZnF-BED domain. We show that both domains are required ... F-box protein, a core component of the Skp1-Cullin-F-box (SCF) E3 ligase complex, plays an important role in abiotic stress ... Wheat TaPUB1 protein mediates ABA response and seed development through ubiquitination. Zhang, Guangqiang; Yang, Junjiao; Zhao ...

https://pesquisa.bvsalud.org/portal/?lang=pt&q=au:Zhang,+Guangqiang

IPR011989 Armadillo-like helical. IPR015403 Domain of unknown function DUF1981, SEC7 associated. IPR016024 Armadillo-type fold ...

http://monarchbase.umassmed.edu/tools/Get_gene.cgi?id=DPGLEAN18353

... sterile a/Armadillo/Toll-Interleukin receptor homology domain protein) cell-autonomously recapitulated the Wlds phenotype. The ... Sarm1-/- mice developed fewer beta amyloid precursor protein (βAPP) aggregates in axons of the corpus callosum after TBI as ... Remarkably, mice mutant for the Wallerian degeneration slow (Wlds) protein exhibit ~tenfold (for 2-3 weeks) suppressed ...

https://repository.escholarship.umassmed.edu/handle/20.500.14038/44293

ARID1B: AT-rich interaction domain 1B. *ARMC5: armadillo repeat containing 5. *ARMS2: age-related maculopathy susceptibility 2 ... ARHGAP31: Rho GTPase activating protein 31. *ARID1A: AT-rich interaction domain 1A ... ABHD5: abhydrolase domain containing 5, lysophosphatidic acid acyltransferase. *ABL1: ABL proto-oncogene 1, non-receptor ...

https://medlineplus.gov/genetics/gene

Archaeal Proteins. *Armadillo Domain Proteins. *Arthropod Proteins. *Avian Proteins. *Bacterial Proteins. *Blood Proteins ... "Protein Precursors" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Protein Precursors" by people in this website by year, and ... Below are the most recent publications written about "Protein Precursors" by people in Profiles. ...

https://profiles.wakehealth.edu/display/88161

Ras of complex proteins) domain followed by a COR (C-terminal of ROC) domain and a protein kinase domain. In addition, there ... We predict that the armadillo repeats, ankyrin repeats and leucine-rich repeats together form an extended N-terminal flexible ... Homology modelling using known protein structures with similar domains was used to predict structures, exposed residues and ... 1. The Src-family protein tyrosine kinases (SFKs) are multidomain oncogenic protein tyrosine kinases. Their overactivation ...

https://minerva-access.unimelb.edu.au/collections/0c2a0658-1ea3-5ca3-9617-8be4161d4912?spc.page=1&view=listElement&spc.sf=dc.date.available&spc.sd=DESC&f.author=Cheng,%20Heung,equals&f.author=Culvenor,%20Janetta,equals&f.dateIssued.min=2010&f.dateIssued.max=2012

C-terminal domain family domain assignments . Domain assignment details for each protein include region, Evalue and model. ... Alignments, domain architectures and domain combinations are provided for each group of proteins. ... Nine-banded armadillo. 1. 1. No Yes Choloepus hoffmanni 76_1. Hoffmanns two-fingered sloth. 1. 1. ... Wiscott-Aldrich syndrome protein, WASP, C-terminal domain family domain assignments No domain assignments for these genomes.. ...

https://supfam.mrc-lmb.cam.ac.uk/SUPERFAMILY/cgi-bin/genome.cgi?sf=47913

LRRK2 is a large multidomain protein with 2,527 amino acids (MW: 286 kDa) and consists of armadillo repeats (ARM), ankyrin ... repeats (ANK), leucine-rich repeats (LRR), Ras of complex (ROC), C-terminal of ROC (COR), kinase domain (KD), and WD40 domain. ...

https://en.wuxibiortus.com/news/88.html

... has a BTB POX domain for your protein protein interaction within the amino terminal portion in addition to a Zinc Finger domain ... Kaiso protein interacts especially with p120 catenin, a member of the armadillo relatives that owns B catenin. B catenin and ... Cell lysates complete protein amount was quantified using Bradford assay. Proteins have been separated on SDS polyacrylamide ... BMP2 was obtained from joint Protein Central. Prior to use, the lyophilized proteins have been reconstituted in one mM ...

https://phosphorylaseinhibitors.com/2015/03

Armadillo Domain Proteins. M. Peifer, McCrea, P. D., Green, K. J., Wieschaus, E., and Gumbiner, B. M., "The vertebrate adhesive ... "The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form ... "The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form ... "The vertebrate adhesive junction proteins beta-catenin and plakoglobin and the Drosophila segment polarity gene armadillo form ...

https://lsi.princeton.edu/research/publications?s=keyword&o=asc&f%5Bauthor%5D=111

Armadillo repeat-containing protein 10 - Also known as ARM10_HUMAN, ARMC10, SVH. May play a role in cell survival and cell ... Protein families, Compounds, Diseases, Genes, Drugs on the Cancer Drug Discovery Platform , canSAR.ai ... Interacts with the DNA-binding domain of p53/TP53. Also known as ARM10_HUMAN, ARMC10, SVH. May play a role in cell survival and ...

https://cansar.ai/target/Q8N2F6/synopsis/ligandability

Uncharacterized protein OS=Stomoxys calcitrans OX=... [more]. A0A4S2LX82. 8.271e-104. 43.29. GBD/FH3 domain-containing protein ... BLAST of Formin-like protein vs. TrEMBL Match: A0A4S2LX82 (GBD/FH3 domain-containing protein OS=Opisthorchis felineus OX=147828 ... Formin homology 2 domain (FH2 domain). coord: 652..1058. IPR010473. Formin, GTPase-binding domain. SMART. SM01140. Drf_GBD_2. ... Formin-like protein 2 OS=Mus musculus OX=10090 GN=... [more]. sp,Q6NXC0,FMNL3_DANRE. 3.064e-59. 32.14. Formin-like protein 3 OS ...

https://planosphere.stowers.org/feature/Schmitea/mediterranea-sexual/transcript/SMED30014928

Protein Function :. InterPro :. EMI domain , Tumour necrosis fac-like dom , C1q dom , ARM-like [+] , Armadillo , Beta-catenin ...

https://www.xenbase.org/entry/gene/showgene.do?method=displayGeneSummary&geneId=978930&tabId=0

The β-catenin protein known as Armadillo (Arm) in Drosophila is a key effector in the Wnt signaling cascade. In normal ... the receptor complex is endocytosed and the protein Dishevelled (Dvl) form polymers at the cytoplasmic domain of the receptors ... Ubr3 : E3-Ubiquitin protein ligase  Upd : Unpaired like protein  Usp : Ultraspiracle  UTR : Untranslated region  VM : ... EEP divide once before starting to accumulate prospero protein. In addition, the newly formed EEP inherits the protein Numb ...

https://123dok.net/document/z12g1mey-study-role-gene-maintenance-differentiation-intestinal-cells-drosophila.html

Several people had distinct contact with armadillos, including hunting, cooking, or eating armadillos. [12] ... For Schwann cells in particular, the mycobacteria bind to the G domain of the alpha-chain of laminin 2 (found only in ... Utility of measuring serum levels of anti-PGL-I antibody, neopterin and C-reactive protein in monitoring leprosy patients ... However, in 2011, a unique strain of M leprae was genotyped in both humans and wild armadillos infected in the southern United ...

http://emedicine.medscape.com/article/1104977-overview

... a reduction in the level of expression of the anti-apoptotic protein Survivin, upon statin treatment in the APC-mutant cells ... a reduction in the level of expression of the anti-apoptotic protein Survivin, upon statin treatment in the APC-mutant cells ... Protein lysates were run through a column containing a resin with the GST-fusion protein containing the Rho-binding domain of ... The Armadillo Repeat Domain of Apc Suppresses Intestinal Tumorigenesis. Mamm Genome (2010) 21(9-10):450-7. doi: 10.1007/s00335- ...

https://www.frontiersin.org/articles/10.3389/fonc.2022.880552/full

DUF659 domain containing protein - - 5.60519e-45. 71% FL-Next. tr=Putative uncharacterized protein; Medicago truncatula (Barrel ... Armadillo-like helical IPR011989 - 0.0. - Sma3. Pleckstrin homology-like domain IPR011993 - 0.0. - ... hAT dimerization domain-containing protein [Arabidopsis thaliana]. 6.0e-25. 49%. RefSeq. Populus trichocarpa. XP_002307433.1. ... hAT dimerisation domain-containing protein chr3:5972793-5975684 REVERSE LENGTH=877. 5.0e-25. 49%. ...

https://www.scbi.uma.es/sustainpinedb/unigens/28?tab=ung&ung_id=1205266

mitochondrial ribosomal protein.... MS4A7. 58475. MS4A7. membrane spanning 4-domains A7 .... MTAP. 4507. MTAP. ... armadillo repeat containing 7 [.... ATP6V0D2. 245972. ATP6V0D2. ATPase H+ transporting V0 subun.... ... The aim of this study was to quantify the impact of chimeric Foxp3-GFP protein on the Treg cell transcriptional program.. ...

https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/GSE37605_TREG_VS_TCONV_C57BL6_FOXP3_FUSION_GFP_DN.html

Densin belongs to the LAP (leucine-rich repeats [LRR] and PDZ domains) protein family (21). LAP proteins have thus far been ... Densin-180 interacts with delta-catenin/neural plakophilin-related armadillo repeat protein at synapses. J Biol Chem 277: 5345- ... Typical function for the type I PDZ domains is binding to distinct C-terminal sequences of other proteins. It is of particular ... Proteins of the precipitate were subsequently identified with MALDI-TOF mass analysis. One of the proteins thus obtained showed ...

https://journals.lww.com/jasn/pages/articleviewer.aspx?year=2003&issue=07000&article=00003&type=Fulltext

The two encoded protein isoforms, PntP1 and PntP2, share a common C-terminal region, that includes their ETS DNA-binding domain ... For example, the Wnt pathway target genes bind TCF associated with the repressor Groucho/TLE, and, upon activation, Armadillo/β ... The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway ... All other Drosophila ETS proteins are similar to PntP2: they contain the Pnt domain that mediates MAPK association as well as ...

https://cob.silverchair.com/dev/article/140/13/2746/76608/Sequential-activation-of-ETS-proteins-provides-a

... domain,protein tophat: splice junction,mapper,RNA-Seq,genome,biology,bioinformatics,sequence tor-browser: tor,browser tor: ... anonymity armadillo: blas,lapack,linear algebra armagetronad: Tron,armagetron,armagetronad,tron,game,cycles,opengl,old_school ... domain,curses,library,X11,text-mode PDFlib-Lite: pdflib-lite,pdf,pdflib Pafy: youtube,downloader,pafy,ytdl,download,video,music ... protein,pdb,structure,bioinformatics,biology mkcue: abcde,cue mksh: shell,korn shell,mksh,pdksh,ksh mktoc: toc,cue,cdrdao, ...

http://ftp.nluug.nl/os/Linux/distr/salix/sbo/14.1/TAGS.txt

The hLEF/TCF-1 alpha HMG protein contains a context-dependent transcriptional activation domain that induces the TCR alpha ... Wingless directly represses DPP morphogen expression via an armadillo/TCF/Brinker complex. PLoS One. 2007 Jan 03; 2(1):e142. ... Ring Finger Protein 14 is a new regulator of TCF/β-catenin-mediated transcription and colon cancer cell survival. EMBO Rep. ... A WNT/p21 circuit directed by the C-clamp, a sequence-specific DNA binding domain in TCFs. Mol Cell Biol. 2012 Sep; 32(18):3648 ...

https://profiles.icts.uci.edu/marian.waterman

The Armadillo Factor: Lepromatous Leprosy. Cleary, L. C., Suraj, S., Haburchak, D. R. & Turrentine, J. E., Oct 1 2017, In: ... The antigenic relatedness of proteins from human and simian prostate fluid. Carter, D. B., Timmins, J. G., Adams, L. D., Lewis ... The Aspergillus fumigatus cell wall is organized in domains that are remodelled during polarity establishment. Momany, M., ... The antiviral xanthate compound D609 inhibits herpes simplex virus type 1 replication and protein phosphorylation. Walro, D. G. ...

https://augusta.elsevierpure.com/en/publications/?showAdvanced=false&allConcepts=true&inferConcepts=true&publicationYear=2013&publicationYear=2015&publicationYear=2016&publicationYear=2019&publicationYear=2020&format=&ordering=title&descending=false&nofollow=true&page=917

Beta-catenin armadillo repeat domain bound to ICAT. 1pjm. Mouse Importin alpha-bipartite NLS from human retinoblastoma protein ... Click on the protein counts, or double click on taxonomic names to display all proteins containing ARM domain in the selected ... Evolution (species in which this domain is found). * Taxonomic distribution of proteins containing ARM domain.. This tree ... Metabolism (metabolic pathways involving proteins which contain this domain). * % proteins involved. KEGG pathway ID. ...

https://smart.embl.de/smart/do_annotation.pl?DOMAIN=ARM&START=500&END=540&E_VALUE=5.43e1&TYPE=SMART&BLAST=EQKIKADILRSLSTEQLFRLLSDSDMNVLMKTLGLLRNLLS

RanBP9 contains four conserved protein-protein interaction domains and is thought to interact with many protein partners and to ... RanBPM, Muskelin, p48EMLP, p44CTLH, and the armadillo-repeat proteins ARMC8α and ARMC8β are components of the CTLH complex. ... Considering that RanBPM contains only protein-protein interaction domains and functions as a scaffolding protein, it is ... Domain prediction indicated that all proteins had two domains and two motifs, except for the MoRBP9 homolog from O. sativa, ...

https://ppjonline.org/journal/view.php?number=477

THE ARMADILLO. (For Robert Lowell). This is the time of year. when almost every night. the frail, illegal fire balloons appear. ... The question of whether molecules or proteins can be patented remains open. ... Did you grab the domains yet?. * anon ymouse November 21, 2013 at 9:41 pm. le bleu with le rouge stripe? ... a glistening armadillo left the scene,. rose-flecked, head down, tail down, ...

https://www.nakedcapitalism.com/2013/11/47719.html

Which type of protein is present in human skin? › Collagen. Collagen is the most abundant structural protein in the connective ... The mnemonic is "Armadillos Take In New Ants": Application, Transport, Internet, Network Access. Also mapped to the OSI Layers. ... To remember the order of taxa in biology (Domain, Kingdom, Phylum, Class, Order, Family, Genus, Species, [Variety]): "Dear King ... The skin is the bodys largest organ, made of water, protein, fats and minerals. Your skin protects your body from germs and ...

https://coeler.pics/article/skin-layers-seer-training

Acquiring a domain is also totally free when you are making use of cost-free blogger sites.Rule No. 1: Show and Inform. Most ... narrated by an armadillo. Such imagination! Show and Inform, followed by a good nap.Writing actually good content - what I ... eggs include high levels of proteins which assist in the formation of new hair. It is also rich in sulphur, zinc, iron, ... You will alienate your friends and contacts if you come across as a pushy salesperson.Your domain name is your on the web ...

http://jaquelinemcintire.wikidot.com/blog:_start/date/2018.1

LRRK2 is a large multidomain protein with 2,527 amino acids (MW: 286 kDa) and consists of armadillo repeats (ARM), ankyrin repeats (ANK), leucine-rich repeats (LRR), Ras of complex (ROC), C-terminal of ROC (COR), kinase domain (KD), and WD40 domain. (wuxibiortus.com)

A family of proteins that contain several 42-amino acid repeat domains and are homologous to the Drosophila armadillo protein. (nih.gov)
Familia de proteínas que contienen varios dominios de repetición de 42 aminioácidos y son homólogas a la proteína armadillo de Drosophila. (bvsalud.org)

The structure of the ARMC5 protein contains ARM repeats and a BT. (endocrine-abstracts.org)
Expanded CAG TRINUCLEOTIDE REPEATS have been identified in the Huntingtin (HD) Gene of patients with HUNTINGTON DISEASE and are associated with abnormal PROTEIN AGGREGATES . (nih.gov)
The protein encoded by this gene contains 9 'Armadillo' repeats and interacts with the smg GDS protein through these repeats. (nih.gov)

Background: Germline mutations of ARMC5 (Armadillo repeat containing 5 gene) were identified as a frequent cause of primary bilateral macronodular adrenal hyperplasia (PBMAH). (endocrine-abstracts.org)
Background: ARMC5 (armadillo repeat containing 5) has been identified as the gene responsible for PBMAH (Primary Bilateral Macronodular Adrenal Hyperplasia). (endocrine-abstracts.org)

12. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. (nih.gov)
They are large multi-domain proteins containing two putative catalytic domains, a GTPase ROCO domain and a kinase domain, in addition to armadillo, ankyrin, leucin rich and WD40 domains. (nih.gov)
WD40 repeat-containing protein [Rivularia sp. (gzybioinformatics.cn)

No InterPro domain matches or not analyzed. (cornell.edu)

Interacts with the DNA-binding domain of p53/TP53. (cansar.ai)

5. Intrinsically disordered protein NUPR1 binds to the armadillo-repeat domain of Plakophilin 1. (nih.gov)
10. The armadillo-repeat domain of plakophilin 1 binds the C-terminal sterile alpha motif (SAM) of p73. (nih.gov)
2. Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3. (nih.gov)
4. Striatins contain a noncanonical coiled coil that binds protein phosphatase 2A A subunit to form a 2:2 heterotetrameric core of striatin-interacting phosphatase and kinase (STRIPAK) complex. (nih.gov)
Arp2-3 complex binds WASP PROTEIN and existing ACTIN FILAMENTS, and it nucleates the formation of new branch point filaments. (nih.gov)
HN - 2006 BX - Arp2-3 Complex MH - Actin-Related Protein 3 UI - D051378 MN - D5.750.78.730.246.750 MN - D12.776.220.525.246.750 MS - A component of the Arp2-3 complex that is related in sequence and structure to ACTIN and that binds ATP. (nih.gov)
Binds to the tail domain of the KIF3A/KIF3B heterodimer to form a heterotrimeric KIF3 complex and may regulate the membrane binding of this complex (By similarity). (nih.gov)

Description of the protein which includes the UniProt Function and the NCBI Gene Summary. (nih.gov)
These proteins are related to the active E3 Ubiquitin Ligases and can be sorted alphabetically by Gene Symbol or Class by clicking on the respective header. (nih.gov)

β-catenin contacts a disordered FOXP2 region with α-helical propensity via its folded armadillo domain, whereas the intrinsically disordered β-catenin N terminus and C terminus bind to the conserved FOXP2 DNA-binding domain. (medunigraz.at)

Cloning of the chicken and quail genes encoding the putative receptor for RSV, subgroup A. Although the sequencing of genes encoding this long-sought receptor is not yet complete, it will undoubtedly offer a new perspective on viral-host interactions, the mechanism of early events in the virus life cycle, and the nature of the presumptively polymorphic avian proteins that recognize the several subgroups of RSV. (nih.gov)

This is a PFAM domain. (embl.de)

Sterile alpha and heat/Armadillo motif 1 (SARM1) is a protein expressed in neurons of the brain that plays a critical role in axonal degeneration. (nih.gov)

This list was created primarily from Supplemental Table 1 of Li et al , with the addition of the Cullin proteins. (nih.gov)

Demonstration that an ectopically expressed transmembrane protein (human CD4) can be efficiently incorporated into RSV envelopes during virus assembly (8). (nih.gov)

7. Plakophilins 1 and 3 bind to FXR1 and thereby influence the mRNA stability of desmosomal proteins. (nih.gov)
They bind to other proteins through their armadillo domains and play a variety of roles in the CELL including SIGNAL TRANSDUCTION , regulation of DESMOSOME assembly, and CELL ADHESION . (nih.gov)
AN - coordinate IM with ADENOMA (IM) HN - 2006 BX - Corticotroph Adenoma BX - Pituitary Adenoma, ACTH-Secreting BX - Pituitary Corticotropin-Secreting Adenoma MH - Actin Capping Proteins UI - D051344 MN - D5.750.78.730.32 MN - D12.776.220.525.32 MS - Actin capping proteins are cytoskeletal proteins that bind to the ends of ACTIN FILAMENTS to regulate actin polymerization. (nih.gov)

3. Several recent publications indicate the presence of a 'hydrophobic spine' formed by four conserved interacting hydrophobic residues in the kinase domain of SFKs. (edu.au)

Oncogenic kinase fusion proteins represent an important class of cancer drivers. (nih.gov)
1. The Src-family protein tyrosine kinases (SFKs) are multidomain oncogenic protein tyrosine kinases. (edu.au)

3. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (nih.gov)
15. Striatin-1 is a B subunit of protein phosphatase PP2A that regulates dendritic arborization and spine development in striatal neurons. (nih.gov)

Protein kinases regulate almost every aspect of cellular function through phosphorylation of their substrates. (nih.gov)
In addition to phosphorylating SFKs, CHK also performs non-SFK-related functions by phosphorylating other cellular protein substrates. (edu.au)
Besides β-synuclein, cellular proteins containing motifs resembling this sequence are potential CHK substrates. (edu.au)

The transcription factor forkhead box protein P2 (FOXP2) is a highly conserved key regulator of embryonal development. (medunigraz.at)

LRRK1 is slightly smaller than LRRK2 due to the lack of an N-terminal armadillo repeat domain. (nih.gov)
Kelch repeat type 1-containing protein [Acidovorax avenae subsp. (gzybioinformatics.cn)
WD-40 repeat-containing protein [Roseiflexus sp. (gzybioinformatics.cn)

It is driven by J-PKAcα, which is a kinase fusion chimera of the J-domain of heat shock co-chaperone DNAJB1 with PKAcα, the catalytic subunit of PKA, which has been used as a model system for the kinase family for the last 40 years. (nih.gov)

13. Alterations in desmosome size and number coincide with the loss of keratinocyte cohesion in skin with homozygous and heterozygous defects in the desmosomal protein plakophilin 1. (nih.gov)

Characterization of src mutants with host-dependent and dominant-negative phenotypes that define important functional domains outside the protein-tyrosine kinase domain of sre proteins (15, 16, 17, 18). (nih.gov)

6. SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions. (nih.gov)
The long-term goal of our studies is to gain a better understanding of how these large multi-domain kinases affect human health. (nih.gov)
In conjunction with work in several other labs, these mutants brought the Src-homology (SH) domains 2 and 3 to widespread attention, providing new opportunites for identifying the proteins that are crucial modifiers and targets for Sre-like kinases. (nih.gov)

Background: Cushing syndrome due to PPNAD is the main endocrine disorder of CNC, an autosomal dominant multiple neoplasia caused by germline inactivating mutations of the subunit type 1A (PRKAR1A) of the protein kinase A (PKA). (endocrine-abstracts.org)

Despite similar domain organizations, LRRK1 and LRRK2 have distinct interactomes and distinct physiological functions. (nih.gov)

The demonstration that recombinant Arabidopsis variant P protein has NO-synthesizing activity was a critical piece of evidence leading to the above conclusion. (nih.gov)

The majority of loss-of function mutations of G protein coupled receptors, leading to diseases, such as diabetes insipidus (V2 vasopressin receptor) or retinitis pigmentosa (rhodopsin) are consecutive to retention of the receptor in the endoplasmic reticulum (ER). (endocrine-abstracts.org)

5. Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization. (nih.gov)
Kinase signaling systems function as multi-domain and multi-component entities to achieve precise regulation of biological processes, and they are frequently deregulated in human diseases. (nih.gov)
Deletion of DJ-1 in rats affects protein abundance and mitochondrial function at the synapse. (ouhsc.edu)
These experiments test the function of altered forms of Armadillo that are targeted inside or outside of the nucleus or that contain heterologous transcriptional activator or repressor domains. (nih.gov)
Biochemical and genetic characterization of Wnt-1 protein as a secretory glycoprotein (11,12) that can function in autocrine or paracrine modes, presumably by interaction with membrane receptor(s). (nih.gov)

2. Although many upstream regulators and protein substrates of SFKs have been identified, both the mechanisms of activation and catalysis of SFKs are not fully understood. (edu.au)
Thus, besides assisting in the identification of potential CHK physiological substrates, our findings shed new light on how CHK recognizes SFKs and other protein substrates. (edu.au)

Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (nih.gov)

Assignment of Homology to Genome Sequences using a Library of Hidden Markov Models that Represent all Proteins of Known Structure. (cam.ac.uk)
Figure 1 Domain organization of N terminal kinesin, C terminal kinesin and internal kinesin The arrows represent the direction of movement. (chinbullbotany.com)

HN - 2006(1981) BX - Cofilins MH - Actin-Related Protein 2 UI - D051377 MN - D5.750.78.730.246.500 MN - D12.776.220.525.246.500 MS - A PROFILIN binding domain protein that is part of the Arp2-3 complex. (nih.gov)
HN - 2006(1998) MH - Actin-Related Protein 2-3 Complex UI - D051376 MN - D5.750.78.730.246 MN - D12.776.220.525.246 MS - A complex of seven proteins including ARP2 PROTEIN and ARP3 PROTEIN that plays an essential role in maintenance and assembly of the CYTOSKELETON. (nih.gov)
We continue to study the impact of J-domain fusion of PKA complex structures and regulation. (nih.gov)
This paper (Cell 113, 115-125, April 4, 2003) reports results of experiments that together strongly support the conclusion that, in metazoan cells, formation of a complex consisting of the GTP binding protein Ran, the exportin Crm1, and the DNA helicase MCM plays a critical role in limiting DNA replication to a single round each cell cycle. (nih.gov)

We are a basic research laboratory that studies the structural and functional basis of protein kinase signaling. (nih.gov)

This paper presents a series of experiments that challenge the conventional view that Armadillo transduces Wingless by combining with Pangolin to form a transcriptional activator. (nih.gov)

1. Elucidation of the inhibitory potential of flavonoids against PKP1 protein in non-small cell lung cancer. (nih.gov)

This protein, which is highly concentrated around the endoplasmic reticulum, is phosphorylated by v-src, and this phosphorylation reduces the affinity of the protein for smg GDS. (nih.gov)

Anatomy1

Organisms5

Diseases1

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes14

Information Science4

Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. (1/286)

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. (2/286)

The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling. (3/286)

The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila. (4/286)

Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro. (5/286)

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. (6/286)

Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. (7/286)

Roles of the C terminus of Armadillo in Wingless signaling in Drosophila. (8/286)

No images available that match "armadillo domain proteins"

Armadillo Domain Proteins

Armadillos

Xenarthra

Wnt1 Protein

Drosophila Proteins

LIM Domain Proteins

Sequence Homology, Amino Acid

Protein Binding

Transcription Factors

Mycobacterium leprae

Molecular Sequence Data

Cytoskeletal Proteins

Plakophilins

gamma Catenin

Drosophila

Protein Structure, Tertiary

Insect Proteins

Fas-Associated Death Domain Protein

Recombinant Fusion Proteins

Amino Acid Sequence

Trans-Activators

Sequence Alignment

Catenins

Desmoplakins

Signal Transduction

Binding Sites

Carrier Proteins

Two-Hybrid System Techniques

MADS Domain Proteins

beta Catenin

src Homology Domains

Protein Interaction Domains and Motifs

DNA-Binding Proteins

Leprosy

Cloning, Molecular

Amino Acid Motifs

Membrane Proteins

Adaptor Proteins, Signal Transducing

Base Sequence

Mutation

PDZ Domains

alpha Catenin

Recombinant Proteins

Protein Conformation

Cadherins

Protein Structure, Secondary

Drosophila melanogaster

Nuclear Proteins

Glycogen Phosphorylase

Glycogen Phosphorylase, Liver Form

Uridine Phosphorylase

Imino Furanoses

Phosphorylases

Software

Cells, Cultured

Membrane-tethered Drosophila Armadillo cannot transduce Wingless signal on its own. (1/286)

Negative regulation of Wingless signaling by D-axin, a Drosophila homolog of axin. (2/286)

The ciD mutation encodes a chimeric protein whose activity is regulated by Wingless signaling. (3/286)

The C-terminal domain of armadillo binds to hypophosphorylated teashirt to modulate wingless signalling in Drosophila. (4/286)

Functional characterization of multiple transactivating elements in beta-catenin, some of which interact with the TATA-binding protein in vitro. (5/286)

A Drosophila Axin homolog, Daxin, inhibits Wnt signaling. (6/286)

Frizzled and Dfrizzled-2 function as redundant receptors for Wingless during Drosophila embryonic development. (7/286)

Roles of the C terminus of Armadillo in Wingless signaling in Drosophila. (8/286)

Adhesome

Plakophilin-2

ARMCX1

ARMCX3

Armadillo repeat

Catenin beta-1

Toll-like receptor 4

Chromosome 10

Chromosome 19

Tandem repeat

Protein domain

Solenoid protein domain

TMCO6

ARMH3

ARVCF

Importin α

LRRK2