Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).
A plant genus of the family ARISTOLOCHIACEAE. Species of this genus have been used in traditional medicine but they contain aristolochic acid which is associated with nephropathy. These are sometimes called 'snakeroot' but that name is also used with a number of other plants such as POLYGALA; SANICULA; ASARUM; ARISTOLOCHIA; AGERATINA; and others.
A form of chronic interstitial nephritis that is endemic to limited areas of BULGARIA, the former YUGOSLAVIA, and ROMANIA. It is characterized by a progressive shrinking of the KIDNEYS that is often associated with uroepithelial tumors.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
Tumors or cancer of the URINARY TRACT in either the male or the female.
Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
The study of medicines derived from botanical sources.
Isocoumarins found in ASPERGILLUS OCHRACEUS and other FUNGI. Ochratoxin contaminated FOOD has been responsible for cases of FOODBORNE DISEASES.
An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)
The study of the actions and properties of medicinal agents, often derived from PLANTS, indigenous to populations or ETHNIC GROUPS.
Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.
Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.
Agents capable of exerting a harmful effect on the body.
A genus of sphinx or hawk moths of the family Sphingidae. These insects are used in molecular biology studies during all stages of their life cycle.
A republic located south of HUNGARY, west of ROMANIA and BULGARIA, and part of the former YUGOSLAVIA. The capital is Belgrade.
Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.
Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.
A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.
Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.
Created 7 April 1992 as a result of the division of Yugoslavia.
Pathological processes of the KIDNEY or its component tissues.
A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.
A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.
A publication issued at stated, more or less regular, intervals.
Tumors or cancers of the KIDNEY.
The concept pertaining to the health status of inhabitants of the world.
Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.
One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.
The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.
The epithelial lining of the URINARY TRACT.
A discipline or occupation concerned with the study of INSECTS, including the biology and the control of insects.
A plant family of the order Aristolochiales subclass Magnoliidae class Magnoliopsida. They are mostly tropical woody vines and a few temperate-zone species. The flowers are 3-parted; some species lack petals while others are large and foul smelling.
Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.

Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. (1/122)

BACKGROUND: We have studied interleukin-1 (IL-1)-stimulated signals and gene expression in mesangial cells (MCs) to identify molecular mechanisms of MC activation, a process characteristic of glomerular inflammation. The JNK1 pathway has been implicated in cell fate decisions, and IL-1 stimulates the Jun N-terminal/stress-activated protein kinases (JNK1/SAPK). However, early postreceptor mechanisms by which IL-1 activates these enzymes remain unclear. Free arachidonic acid (AA) activates several protein kinases, and because IL-1 rapidly stimulates phospholipase A2 (PLA2) activity release AA, IL-1-induced activation of JNK1/SAPK may be mediated by AA release. METHODS: MCs were grown from collagenase-treated glomeruli, and JNK/SAPK activity in MC lysates was determined using an immunocomplex kinase assay. RESULT: Treatment of MCs with IL-1 alpha induced a time-dependent increase in JNK1/SAPK kinase activity, assessed by phosphorylation of the activating transcription factor-2 (ATF-2). Using similar incubation conditions, IL-1 also increased [3H]AA release from MCs. Pretreatment of MCs with aristolochic acid, a PLA2 inhibitor, concordantly reduced IL-1-regulated [3H]AA release and JNK1/SAPK activity, suggesting that cytosolic AA in part mediates IL-1-induced JNK1/SAPK activation. Addition of AA stimulated JNK1/SAPK activity in a time- and concentration-dependent manner. This effect was AA specific, as only AA and its precursor linoleic acid stimulated JNK1/SAPK activity. Other fatty acids failed to activate JNK1/SAPK. Pretreatment of MCs with specific inhibitors of AA oxidation by cyclooxygenase, lipoxygenase, and cytochrome P-450 epoxygenase had no effect on either IL-1- or AA-induced JNK1/SAPK activation. Furthermore, stimulation of MCs with the exogenous cyclooxygenase-, lipoxygenase-, phosphodiesterase-, and epoxygenase-derived arachidonate metabolites, in contrast to AA itself, did not activate JNK1/SAPK. CONCLUSION: We conclude that IL-1-stimulated AA release, in part, mediates stimulation of JNK1/SAPK activity and that AA activates JNK1/SAPK by a mechanism that does not require enzymatic oxygenation. JNK1 signaling pathway components may provide molecular switches that mediate structural rearrangements and biochemical processes characteristic of MC activation and could provide a novel target(s) for therapeutic intervention.  (+info)

Pentoxifylline-stimulated capacitation and acrosome reaction in hamster spermatozoa: involvement of intracellular signalling molecules. (2/122)

We investigated the role of cAMP/cGMP, protein kinases and intracellular calcium ( [Ca2+]i) in pentoxifylline-stimulated hamster sperm capacitation and the acrosome reaction (AR) in vitro. Treatment with pentoxifylline (0.45 mM) initially increased sperm cAMP values 2.8-fold, compared with untreated controls (396 +/- 9.2 versus 141 +/- 6.0 fmoles/10(6) spermatozoa; mean +/- SEM, n = 6) after 15 min, although by 3 h, cAMP values were similar (503-531 fmoles/10(6) spermatozoa). cGMP values ( approximately 27 fmoles/10(6) spermatozoa) were the same in treated and control spermatozoa. Both sperm capacitation and the AR, determined from the absence of an acrosomal cap, were stimulated by pentoxifylline; these were almost completely inhibited by a Cl-/ HCO3- antiporter inhibitor (4,4-diisothiocyanato-stilbene-2,2 disulphonic acid; 1 mM) defined from the degree of sperm motility and by a protein kinase A inhibitor (H89; 10 microM). A protein kinase C inhibitor (staurosporine, 1 nM) did not affect pentoxifylline-stimulated capacitation but inhibited the AR by 50%. A protein tyrosine kinase inhibitor (tyrphostin A-47, 0.1 mM) had no effect on either pentoxifylline-stimulated capacitation or AR. A phospholipase A2 inhibitor (aristolochic acid, 0.4 mM) markedly inhibited the pentoxifylline-stimulated AR but not capacitation. When intracellular sperm calcium [Ca2+/-]i was measured using fura-2-AM, there was an early rise (271 nM at 0.5 h) in pentoxifylline-treated spermatozoa; this appeared to be due to intracellular mobilization rather than to uptake. In the absence of extracellular Ca2+, sperm motility was maintained in the presence of pentoxifylline, but capacitation did not occur; spermatozoa exhibited a low level of hyperactivated motility and had a poor rate of AR (20.5 +/- 2.3%). These results suggest that: (i) the pentoxifylline-stimulated early onset of sperm capacitation may be mediated by an early rise in cAMP and [Ca2+/-]i and involves protein kinase A activity; and (ii) pentoxifylline-stimulated AR may require phospholipase A2 and protein kinase C activity.  (+info)

Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent. (3/122)

Recent work indicates that respiratory muscles generate superoxide radicals during contraction (M. B. Reid, K. E. Haack, K. M. Francik, P. A. Volberg, L. Kabzik, and M. S. West. J. Appl. Physiol. 73: 1797-1804, 1992). The intracellular pathways involved in this process are, however, unknown. The purpose of the present study was to test the hypothesis that contraction-related formation of reactive oxygen species (ROS) by skeletal muscle is linked to activation of the 14-kDa isoform of phospholipase A(2) (PLA(2)). Studies were performed by using an in vitro hemidiaphragm preparation submerged in an organ bath, and formation of ROS in muscles was assessed by using a recently described fluorescent indicator technique. We examined ROS formation in resting and contracting muscle preparations and then determined whether contraction-related ROS generation could be altered by administration of various PLA(2) inhibitors: manoalide and aristolochic acid, both inhibitors of 14-kDa PLA(2); arachidonyltrifluoromethyl ketone (AACOCF(3)), an inhibitor of 85-kDa PLA(2); and haloenol lactone suicide substrate (HELSS), an inhibitor of calcium-independent PLA(2). We found 1) little ROS formation [2.0 +/- 0.8 (SE) ng/mg] in noncontracting control diaphragms, 2) a high level of ROS (20.0 +/- 2.0 ng/mg) in electrically stimulated contracting diaphragms (trains of 20-Hz stimuli for 10 min, train rate 0.25 s(-1)), 3) near-complete suppression of ROS generation in manoalide (3.0 +/- 0.5 ng/mg, P < 0. 001)- and aristolochic acid-treated contracting diaphragms (4.0 +/- 1.0 ng/mg, P < 0.001), and 4) no effect of AACOCF(3) or HELSS on ROS formation in contracting diaphragm. During in vitro studies examining fluorescent measurement of ROS formation in response to a hypoxanthine/xanthine oxidase superoxide-generating solution, manoalide, aristolochic acid, AACOCF(3), and HELSS had no effect on signal intensity. These data indicate that ROS formation by contracting diaphragm muscle can be suppressed by the administration of inhibitors of the 14-kDa isoform of PLA(2) and suggest that this enzyme plays a critical role in modulating ROS formation during muscle contraction.  (+info)

W-7 induces [Ca(2+)](i) increases in Madin-Darby canine kidney (MDCK) cells. (4/122)

The effect of W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride] on Ca(2+) signaling in Madin-Darby canine kidney cells was investigated. W-7 (0.1-1 mM) induced a [Ca(2+)](i) increase, which comprised an initial increase and a plateau. Ca(2+) removal inhibited the Ca(2+) signals by 80%, suggesting that W-7 activated external Ca(2+) influx and internal Ca(2+) release. Pretreatment with the mitochondrial uncoupler carbonylcyanide m-chlorophenylhydrazone (2 microM) and the endoplasmic reticulum Ca(2+) pump inhibitor thapsigargin (1 microM) abolished the internal Ca(2+) release induced by 0.5 mM W-7; conversely, pretreatment with W-7 prevented thapsigargin and carbonylcyanide m-chlorophenylhydrazone from releasing internal Ca(2+). W-7 (0.2 mM) induced Mn(2+) quench of fura-2 fluorescence, which was inhibited by La(3+) (0.1 mM) by 80%. La(3+) (0.1 mM) partly inhibited 0.2 mM W-7-induced [Ca(2+)](i) increase. Addition of 5 mM Ca(2+) induced a significant [Ca(2+)](i) increase after pretreating with 0.2 to 1 mM W-7 in Ca(2+)-free medium for 5 min, suggesting that W-7 induced capacitative Ca(2+) entry. W-7 (0.5 mM) potentiated the capacitative Ca(2+) entry induced by 1 microM thapsigargin by 15%. Pretreatment with aristolochic acid (40 microM) to inhibit phospholipase A(2) reduced 0.5 mM W-7-induced internal Ca(2+) release and external Ca(2+) influx by 25 and 80%, respectively. Inhibition of phospholipase C with U73122 (2 microM) or inhibition of phospholipase D with propranolol (0.1 mM) had no effect on the internal Ca(2+) release induced by 0.5 mM W-7. It remains unclear whether W-7 induced [Ca(2+)](i) increases via inhibition of calmodulin. Three other calmodulin inhibitors (phenoxybenzamine, trifluoperazine, and fluphenazine-N-chloroethane) did not alter resting [Ca(2+)](i).  (+info)

Using polymerase arrest to detect DNA binding specificity of aristolochic acid in the mouse H-ras gene. (5/122)

The distribution of DNA adducts formed by the two main components, aristolochic acid I (AAI) and aristolochic acid II (AAII), of the carcinogenic plant extract aristolochic acid (AA) was examined in a plasmid containing exon 2 of the mouse c-H-ras gene by a polymerase arrest assay. AAI and AAII were reacted with plasmid DNA by reductive activation and the resulting DNA adducts were identified as the previously characterized adenine adducts (dA-AAI and dA-AAII) and guanine adducts (dG-AAI and dG-AAII) by the (32)P-post-labeling method. In addition, a structurally unknown adduct was detected in AAII-modified DNA and shown to be derived from reaction with cytosine (dC-AAII). Sites at which DNA polymerase progress along the template was blocked were assumed to be at the nucleotide 3' to the adduct. Polymerase arrest spectra showed a preference for reaction with purine bases in the mouse H-ras gene for both activated compounds, consistent with previous results that purine adducts are the principal reaction products of AAI and AAII with DNA. Despite the structural similarities among AAI-DNA and AAII-DNA adducts, however, the polymerase arrest spectra produced by the AAs were different. According to the (32)P-post-labeling analyses reductively activated AAI showed a strong preference for reacting with guanine residues in plasmid DNA, however, the polymerase arrest assay revealed arrest sites preferentially at adenine residues. In contrast, activated AAII reacted preferentially with adenine rather than guanine residues and to a lesser extent with cytosine but DNA polymerase was arrested at guanine as well as adenine and cytosine residues with nearly the same average relative intensity. Thus, the polymerase arrest spectra obtained with the AA-adducted ras sequence do not reflect the DNA adduct distribution in plasmid DNA as determined by (32)P-post-labeling. Arrest sites of DNA polymerase associated with cytosine residues confirmed the presence of a cytosine adduct in DNA modified by AAII. For both compounds adduct distribution was not random; instead, regions with adduct hot spots and cold spots were observed. Results from nearest neighbor binding analysis indicated that flanking pyrimidines displayed the greatest effect on polymerase arrest and therefore on DNA binding by AA.  (+info)

Stimulation of Ca(2+)-dependent exocytosis of the sperm acrosome by cAMP acting downstream of phospholipase A2. (6/122)

Spermatozoa undergo exocytosis in response to agonists that induce Ca2+ influx and, in turn, activation of phosphoinositidase C, phospholipase C, phospholipase A2, and cAMP formation. Since the role of cAMP downstream of Ca2+ influx is unknown, this study investigated whether cAMP modulates phospholipase C or phospholipase A2 using a ram sperm model stimulated with A23187 and Ca2+. Exposure to dibutyryl-cAMP, phosphodiesterase inhibitors or forskolin resulted in enhancement of exocytosis. However, the effect was not due to stimulation of phospholipase C or phospholipase A2: in spermatozoa prelabelled with [3H]palmitic acid or [14C]arachidonic acid, these reagents did not enhance [3H]diacylglycerol formation or [14C]arachidonic acid release. Spermatozoa were treated with the phospholipase A2 inhibitor aristolochic acid, and dibutyryl-cAMP to test whether cAMP acts downstream of phospholipase A2. Under these conditions, exocytosis did not occur in response to A23187 and Ca2+. However, inclusion of dibutyryl-cAMP and the phospholipase A2 metabolite lysophosphatidylcholine did result in exocytosis (at an extent similar to that seen when cells were treated with A23187/Ca2+ and without the inhibitor). Inclusion of lysophosphatidylcholine alone, without dibutyryl-cAMP, enhanced exocytosis to a lesser extent, demonstrating that cAMP requires a phospholipase A2 metabolite to stimulate the final stages of exocytosis. These results indicate that cAMP may act downstream of phospholipase A2, exerting a regulatory role in the exocytosis triggered by physiological agonists.  (+info)

Effects of inhibitors of arachidonic acid turnover on the production of prostaglandins by the guinea-pig uterus. (7/122)

The supply of free arachidonic acid from phospholipids is generally regarded as the rate-limiting step for prostaglandin (PG) synthesis by tissues. Two enzymes involved in arachidonic acid uptake into, and release from, phospholipids are acyl-CoA:lysophospholipid acyltransferase (ACLAT) and phospholipase A2 (PLA2), respectively. PGF2 alpha produced by the endometrium induces luteolysis in several species including guinea-pigs. Thimerosal, an inhibitor of ACLAT, and aristolochic acid, an inhibitor of PLA2, both reduced, in a concentration-dependent manner, the output of PGF2 alpha from guinea-pig endometrium cultured for 24 h on days 7 and 15 of the oestrous cycle. This study showed that the continual production of PGF 2 alpha by guinea-pig endometrium is not only dependent upon the activity of PLA2 for releasing free arachidonic acid for PGF2 alpha synthesis, but also on the incorporation of arachidonic acid into the phospholipid pool by the activity of ACLAT. The inhibitory effects of thimerosal and aristolochic acid on the outputs of PGE2 and 6-keto-PGF1 alpha were less marked, particularly on day 7 when the low output of PGE2 was unaffected and the output of 6-keto-PGF1 alpha was increased at the lower concentrations of thimerosal. This finding indicates that there are different pools of arachidonic acid bound as phospholipid for the syntheses of PGF2 alpha and 6-keto-PGF1 alpha by guinea-pig endometrium.  (+info)

Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) (8/122)

BACKGROUND: Chinese-herb nephropathy is a progressive form of renal fibrosis that develops in some patients who take weight-reducing pills containing Chinese herbs. Because of a manufacturing error, one of the herbs in these pills (Stephania tetrandra) was inadvertently replaced by Aristolochia fangchi, which is nephrotoxic and carcinogenic. METHODS: The diagnosis of a neoplastic lesion in the native urinary tract of a renal-transplant recipient who had Chinese-herb nephropathy prompted us to propose regular cystoscopic examinations and the prophylactic removal of the native kidneys and ureters in all our patients with end-stage Chinese-herb nephropathy who were being treated with either transplantation or dialysis. Surgical specimens were examined histologically and analyzed for the presence of DNA adducts formed by aristolochic acid. All prescriptions written for Chinese-herb weight-reducing compounds during the period of exposure (1990 to 1992) in these patients were obtained, and the cumulative doses were calculated. RESULTS: Among 39 patients who agreed to undergo prophylactic surgery, there were 18 cases of urothelial carcinoma (prevalence, 46 percent; 95 percent confidence interval, 29 to 62 percent): 17 cases of carcinoma of the ureter, renal pelvis, or both and 1 papillary bladder tumor. Nineteen of the remaining patients had mild-to-moderate urothelial dysplasia, and two had normal urothelium. All tissue samples analyzed contained aristolochic acid-related DNA adducts. The cumulative dose of aristolochia was a significant risk factor for urothelial carcinoma, with total doses of more than 200 g associated with a higher risk of urothelial carcinoma. CONCLUSIONS: The prevalence of urothelial carcinoma among patients with end-stage Chinese-herb nephropathy (caused by aristolochia species) is a high.  (+info)

Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). This review summarizes the significance of AA-derived DNA adducts in the aetiology of UUC leading to specific A:T to T:A transversion mutations (mutational signature) in AAN/BEN-associated tumours, which are otherwise rare in individuals with UCC not exposed to AA. Therefore, such DNA damage produced by AA-DNA adducts is one rare example of the direct association of exposure and cancer development (UUC) in humans, confirming that the covalent binding of carcinogens to DNA is causally related to tumourigenesis. Although aristolochic acid I (AAI), the major component of the natural plant extract AA, might directly cause interstitial nephropathy, enzymatic activation of AAI to reactive intermediates capable of binding to DNA is a necessary step leading to the formation of AA-DNA adducts and
Balkan endemic nephropathy (BEN) is found in certain rural areas of the Balkans and affects at least 25 000 inhabitants. Of the many hypotheses on BEN, the Aristolochia hypothesis has recently gained ground substantiated by the investigations on aristolochic acid nephropathy (AAN). On both clinical and morphological grounds, AAN is very similar to BEN. That exposure to aristolochic acid (AA) of individuals living in endemic areas through consumption of bread made with flour contaminated with seeds of Aristolochia clematitis is responsible for BEN is an old hypothesis, but one which is fully consistent with the unique epidemiologic features of BEN. Here, we propose an approach to investigate AA-induced mutagenesis in BEN that can provide molecular clues to the aetiology of its associated urothelial cancer. The molecular mechanism of AA-induced carcinogenesis demonstrates a strong association between DNA adduct formation, mutation pattern and tumour development. A clear link between urothelial ...
(HealthDay)-Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid (AA) found in Chinese herbs was first reported 20 years ago, AA-induced nephropathy remains ...
Aristolochic acid (AA) is a class of carcinogenic and nephrotoxic nitrophenanthrene carboxylic acids naturally found in Aristolochia plants. These plants have been widely used as herbal medicines and also enter the human food chain as the persistent soil pollutants. It has been known that AA exposure is implicated in multiple cancer types, kidney failure and ovarian dysfunction. However, whether AA exposure would influence the oocyte quality has not yet determined. Here, we document that AAI has the negative effects on the competency of oocyte maturation and fertilization. We show that AAI exposure leads to the oocyte meiotic failure via impairing the meiotic apparatus, displaying a prominently defective spindle assembly, actin dynamics and mitochondrial integrity. AAI exposure also causes the abnormal distribution of cortical granules and ovastacin, which is consistent with the observation that fewer sperm bound to the zona pellucida surrounding the unfertilized AAI-exposed eggs, contributing to the
BACKGROUND: Chinese herbs nephropathy is a new type of subacute interstitial nephropathy reported in women who had followed a slimming regimen including Chinese herbs. METHODS: We report the clinical presentation and follow-up of 15 cases and compare them with a control group of 15 women with interstitial nephropathies of other origins, matched for age, sex, and initial serum creatinine (mean 3 mg/dl). RESULTS: At presentation the Chinese herbs nephropathy group differed from the control group by a lower proteinuria (P = 0.009), a more severe anaemia (P = 0.002), and a higher prevalence of aortic insufficiency (42% vs 0%, P , 0.05). It was further characterized by mild hypertension in 80%, glycosuria and leukocyturia in 40% and asymmetric kidneys in 54% of the cases. During follow-up, deterioration of renal function was faster in the Chinese herbs nephropathy than in the control group (P , 0.05). It was influenced by the duration of Chinese herbs treatment (P = 0.037) and the delay between the ...
Larvae of the butterfly, Battus polydamas archidamas (Papilionidae: Troidini) feed exclusively on aristolochic acid (AAs)-containing Aristolochia species (Aristolochiaceae). The distribution of sequestrated AAs in the tissues (body, integument...
COSMIC Mutational Signatures is a catalogue of curated reference mutational signatures. Curation covers aetiology, acceptance criteria, tissue distribution and other genomic features of each mutational signature. Downloadable signature profiles and other data are freely available.
COSMIC Mutational Signatures is a catalogue of curated reference mutational signatures. Curation covers aetiology, acceptance criteria, tissue distribution and other genomic features of each mutational signature. Downloadable signature profiles and other data are freely available.
Eugene, OR (SafetyAlerts) - East Earth Herb, Inc. is recalling Jade Pharmacy brand Meridian Circulation tablets and liquid extract and Jade Pharmacy brand Quell Fire tablets because they may present a serious health hazard to consumers. The products contain aristolochic acid. Aristolochic acid is a potent carcinogen and nephrotoxin found in certain plants and botanicals. This chemical can cause serious kidney damage and the use of products that contain aristolochic acid has been associated with several occurrences of kidney failure. The use of aristolochic acid containing products has been linked to increased risk of kidney cancer in people who have consumed it.. Jade Pharmacy brand Meridian Circulation, and Jade Pharmacy brand Quell Fire were distributed throughout the United States through licensed health practitioners.. Meridian Circulation and Quell Fire are packaged under the Jade Pharmacy label. Meridian Circulation is available in bottles of 1 oz., 2 oz., and 4 oz. liquid extract and ...
We studied exposure-induced sensitivity changes in an identified taste cell from Manduca sexta, a herbivorous caterpillar. This taste cell occurs within the lateral styloconic sensillum and responds selectively to compounds that humans characterize as bitter (e.g. caffeine, salicin and aristolochic acid). We made extracellular recordings from several classes of identified taste cell within the lateral sensillum, both before and after dietary exposure (for 48 h) to a suprathreshold concentration of caffeine, salicin or aristolochic acid. Our results revealed (1) that dietary exposure to caffeine desensitized the bitter-sensitive taste cell to caffeine, whereas dietary exposure to salicin or aristolochic acid did not desensitize the same taste cell to salicin or to aristolochic acid; (2) that dietary exposure to caffeine failed to alter the responsiveness of the sugar-, salt- or inositol-sensitive taste cells within the same sensillum; (3) that the caffeine-induced desensitization phenomenon ...
A ristolochic acids (AAs) are powerful nephrotoxin and human carcinogen associated with chronic kidney disease and upper urinary tract urothelial carcinomas. ...
Aristolochic acid causes a specific nephropathy (AAN), Balkan endemic nephropathy, and urothelial malignancies. Using Western blotting suitable to determine protein expression, we investigated in several transgenic mouse lines expression of NAD(P)H:quinone oxidoreductase (NQO1)-the most efficient cytosolic enzyme that reductively activates aristolochic acid I (AAI). The mouse tissues used were from previous studies [Arlt et al., Chem. Res. Toxicol. 24 (2011) 1710; Stiborova et al., Toxicol. Sci. 125 (2012) 345], in which the role of microsomal cytochrome P450 (CYP) enzymes in AAI metabolism in vivo had been determined. We found that NQO1 levels in liver, kidney and lung of Cyp1a1⁻/⁻, Cyp1a2⁻/⁻ and Cyp1a1/1a2⁻/⁻ knockout mouse lines, as well as in two CYP1A-humanized mouse lines harboring functional human CYP1A1 and CYP1A2 and lacking the mouse Cyp1a1/1a2 orthologs, differed from NQO1 levels in wild-type mice. NQO1 protein and enzymic activity were induced in hepatic and renal ...
Lu, H., Y. Liang, B. Guan, Y. Shi, Y. Q. Gong, J. Li, W. W. Kong, J. Liu, D. Fang, L. B. Liu, Q. He, M. Shakeel, X. S. Li, L. Q. Zhou and W. M. Ci ...
The spectrum of p53 mutations observed in transitional cell cancers of patients with EN is dominated by A:T → T:A transversions (Fig. 5 A). This result is consistent with the mutational spectra induced by AA-I (or by a mixture of AA-I and AA-II) in (i) the H-ras gene of rats (23, 24), (ii) transgenic rodent models (25, 26), (iii) the p53 gene in a urothelial cancer from a patient with AAN (34), (iv) site-specific mutagenesis studies in which a single dA-AL adduct is transfected into NER-deficient human cells (I.-Y. Yang and M.M., unpublished data), and (v) 9 of 11 immortalized mouse cell lines (Hupki cells) carrying the human p53 gene (27, 28). Indeed, the predominance of A:T → T:A transversions in the p53 mutational spectra may properly be regarded as a mutational signature (35) for human exposure to AA.. Confidence in our conclusion regarding AA and the etiology of EN rests, in part, on the biomarker data reported here and, in part, on studies of AAN in human populations, in particular, a ...
Somatic mutations arising through cell-intrinsic and exogenous processes mark the genome with distinctive patterns termed mutational signatures. The causes of these mutational signatures and the mechanisms by which they arise are only partially understood. It transpires that several mutational signatures are relatively benign, and present in normal cells as well as in cancer cells. However, some mutational signatures are important to recognize clinically because they indicate biological abnormalities that may be targets for therapeutic intervention or serve as prognosticators for outcome.. In this team, we are focused on understanding all aspects of mutational signatures including their aetiologies, the sources of DNA damage that give rise to them, and the mutational mechanisms by which they become etched into the genome, a theme we refer to as Mutagenesis. We are also intrigued by how human cells coordinate physiological responses to the onslaught of DNA injury that they endure, in an effort to ...
Participant has recurrent or refractory osteosarcoma, neuroblastoma, adrenocortical carcinoma, Ewing sarcoma, rhabdomyosarcoma, or any other solid tumor (excluding tumors of the central nervous system [CNS]) previously documented to have breast cancer susceptibility gene (BRCAness) mutational signature (mutational signature 3) on deoxyribonucleic acid (DNA) sequencing of tumor obtained in the relapsed/recurrent disease setting, within 6 (preferably 3) months prior to enrolment. For participants with documented BRCAness mutational signature: Existing information on molecular profiling of the participants tumor tissue must be through a molecular profiling platform such as Individualized Therapy for Relapsed Malignancies in Childhood (INFORM). Molecular profile information must contain information from whole exome sequencing or whole genome sequencing, including the mutation status of BRCA1/2 and other homologous recombination DNA repair (HRR) pathway genes, mutational signatures including ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
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Mutations in cancer cells leave a kind of fingerprint in the DNA of the cells called a mutational signature; each type of cancer has its own.. When we look at mutational signatures in cancer cells, there is a lot of noise. The noise is something we simply do not know a lot about, says Larose. Part of my experimental process is identifying new causes of that noise, and some of that might be gravity. Her theory is that some of the unknown noise in the cancer cells is there as a result of gravity. Since both healthy cells and cells with cancer are affected by gravity, the researchers should be able to detect this in the fingerprints in all our cells.. Im looking for the molecular fingerprint for the gravitational force, she said, in part because it can help explain the meaning of some of the noise in the cancer cells.. Larose says that the mutational signature of gravity has never been studied or even proposed as a concept.. Although there is no gravity in space, there is cosmic ...
Genome integrity is constantly challenged by exogenous and endogenous insults, and mutations are associated with inherited disease and cancer. Here we summarize recent studies that utilized C. elegans whole genome next generation sequencing to experimentally determine mutational signatures associated with mutagen exposure, DNA repair deficiency or a combination of both and discuss the implications of these results for the understanding of cancer genome evolution. The experimental analysis of wild-type and DNA repair deficient nematodes propagated under unchallenged conditions over many generations revealed increased mutagenesis in approximately half of all DNA repair deficient strains, its rate, except for DNA mismatch repair, only being moderately increased. The exposure of wild-type and DNA repair defective strains to selected genotoxins, including UV-B and ionizing radiation, alkylating compounds, aristolochic acid, aflatoxin-B1, and cisplatin enabled the systematic analysis of the relative ...
TP53 is one of the most commonly mutated genes in human tumours. Variations in the types and frequencies of mutations at different tumour sites suggest that they may provide clues to the identity of the causative mutagenic agent. A useful model for studying human TP53 mutagenesis is the partial human TP53 knock-in (Hupki) mouse containing exons 4-9 of human TP53 in place of the corresponding mouse exons. For an in vitro assay, embryo fibroblasts from the Hupki mouse can be examined for the generation and selection of TP53 mutations because mouse cells can be immortalized by mutation of Tp53 alone. Thus far, four environmental carcinogens have been examined using the Hupki embryo fibroblast immortalization assay: (a) UV light, which is linked to human skin cancer; (b) benzo[a] pyrene, which is associated with tobacco smoke-induced lung cancer; (c) 3-nitrobenzanthrone, a suspected human lung carcinogen linked to diesel exposure; and (d) aristolochic acid, which is linked to Balkan endemic ...
The Center for Theoretical Biological Physics PRESENTS Seminar Speaker Ludmil B. Alexandrov Oppenheimer Fellow Center for Nonlinear Studies Los Alamos National Laboratory Abstract: All cancers are caused by somatic mutations. These mutations may be the consequence of the intrinsic slight infidelity of the DNA replication machinery, exogenous or endogenous mutagen exposures, enzymatic modification of DNA, or defective DNA repair. In some cancer types, a substantial proportion of somatic mutations are known to be generated by exogenous carcinogens, for example, tobacco smoking in lung cancers and ultraviolet light in skin cancers, or by abnormalities of DNA maintenance, for example, defective DNA mismatch repair in some colorectal cancers. Each biological process causing mutations leaves a characteristic imprint on the genome of a cancer cell, termed, mutational signature. In this talk, I will present mutational signatures analyses encompassing 12, 023 cancer genomes across 40 distinct types of ...
Scientists have, for the first time, discovered how X-rays and radioactive particles cause cancer in humans by damaging DNA. Researchers from the Wellcome Trust Sanger Institute in the UK have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionising radiation, such as gamma rays, X-rays and radioactive particles. these fingerprint patterns may now enable doctors to identify which tumours have been caused by radiation, and investigate if they should be treated differently. Previous work on cancer had shown that DNA damage often leaves a molecular fingerprint, known as a mutational signature, on the genome of a cancer cell. Researchers looked for mutational signatures in 12 patients with secondary radiation-associated tumours, comparing these with 319 that had not been exposed to radiation. To find out how radiation could cause cancer, we studied the genomes of cancers caused by radiation in comparison to tumours that arose spontaneously, said Peter ...
Click here to download event flyer.. To open the Outlook calendar invite, double click the attached .ics file and click Yes in pop-up window.. Microsoft Teams meeting. Join on your computer or mobile app Click here to join the meeting. Or call in (audio only). +1 412-447-5295,,764805309# United States, Pittsburgh. Phone Conference ID: 764 805 309#. ...
Interstitial fibrosis can be an inevitable outcome of all kinds of progressive chronic kidney disease (CKD). suppressed the immunoreactivity of mTOR signaling, which decreased the inflammatory responses and ECM accumulation in the obstructed kidneys. Isolated macrophages from rapamycin-treated obstructed kidneys presented less inflammatory activity than vehicle groups. In vitro study confirmed that rapamycin significantly inhibited the fibrogenic activation of cultured fibroblasts (NIH3T3 cells), which was induced by the stimulation of TGF-1. Further experiment revealed that rapamycin did not directly inhibit the fibrogenesis of HK2 cells with aristolochic acid treatment. Our findings clarified that rapamycin can ameliorate kidney fibrosis by blocking the mTOR signaling in interstitial macrophages and myofibroblasts. Introduction Tubulointerstitial fibrosis is the final common pathway of a wide variety of chronic progressive kidney diseases. Intense studies have focused on the molecular and ...
Uric acid is the relatively water-insoluble end product of purine nucleotide metabolism. It poses a special problem for humans because of its limited solubility, particularly in the acidic environment of the distal nephron of the kidney.
Carnitine may also interact with 2,3-Dimercapto-1-propanesulfonic acid, 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy), acetaminophen, acetylcholinesterase (AChE) inhibitors, adefovir dipivoxil, adriamycin, agents for blood vessel width, agents for the ears, agents for the eyes, agents for the heart, agents for heart rate regulation, agents for the immune system, agents for the lungs, agents for the nervous system, agents for osteoporosis, agents for promoting urine flow, agents for retrovirus infections (HIV), agents for the stomach, agents toxic to the kidneys or liver, alcohol, alpha-interferon, Alzheimers agents, amiodarone, antibiotics, anticancer agents, antidepressants, anti-inflammatory agents, anti-seizure agents, aristolochic acid, azithromycin, beta blockers, bupivacaine, calcium channel blockers, carboplatin, cefepime, cephalosporins, cholesterol-lowering agents, cinnoxicam, cisplatin, clofibrate, cyclophosphamide, digoxin, doxorubicin, erythropoietin, exercise performance ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Jing is the source of life, health and longevity. We all are born with Jing Essence, which is stored in the Kidneys and which fuels all other energies. As we age, we naturally deplete our Jing essence; but chronic stress, illness and imbalance will exhaust our Jing faster than we can replenish it through foods and herbs. We must nourish Jing daily with acquired nutritive energy derived from healthy foods, water, meditation, exercise and Chinese herbs. To preserve and protect our Jing from depletion, we must avoid drug and alcohol abuse, bulimia or anorexia, excessive exercise and excessive sexual activities. The latter is especially important for men. Most healthy women dont have to worry so much about losing essence through sexual activity. For all women it is more important to preserve blood. Chinese medicine tells us that Blood and Jing Essence share the same source. Blood preservation is especially important for a woman because when she loses blood, she loses Jing. The wisdom of a womans ...
I spoke to a Kung Fu brother who was an acupuncturist and Chinese Herbalist. He advised me that some of the herbs on the list were not safe to use or unavailable within a western society. He recommended some alternatives that had the same healing properties, this was the birth of a unique but effective formula. I had created my own Dit Da Jow.. Keeping with tradition I also sought out a local Doctor and Chinese Herbalist. With her help and guidance, we formulated the unique blend of herbs that are still being today, that was over 10 years ago. ...
For some time now, I have been hearing a lot about the so called ABC Miracle Drink. Basically juicing beetroot, carrot and an apple. The health benefits of these 3 ingredients are incredible. Numerous studies and research have been done on these ingredients and they have found that they literally slow down the formation and growth of cancer cells (hence naming it the Miracle drink). Chinese herbalists have also long been using it for its cancer preventative properties. And in one study, a Chinese herbalist gave it to his patient suffering from lung cancer, and had him drink it every day and after 3 months, he was cured of the disease! Among some of the health benefits that this juice has been effective in treating are: 1. Slows down the process/development of cancer. Restraining cancer cells from growing further. 2. Prevent liver, kidney and pancreas disease. (Reported to also cure ulcers.) 3. Strengthen the lungs, prevent heart attack and high blood pressure. 4. Strengthen the immune system ...
Heat: characterized by appearance of redness, burning or heat sensation, and symptom worsens with alcohol, anger/stress, hot/spicy food, and hot weather.. Wind: characterized by quick onset, and movement of symptoms to different areas of the body, itchiness, and aversion to wind.. Damp: characterized by oozing or weeping conditions, feeling of body heaviness. Dampness can also be an internally generated factor worsened by eating rich, oily or dairy foods.. Dry: characterized by scaly itchy skin which is worse in dry, winter or autumn weather.. Cold: characterized by open sores, purplish color, wet discharge and slow healing, and usually a chronic condition.. Q: How is the imbalance analyzed?. A: Important factors are considered before making each individual diagnosis and treatment plan. Aside from careful inspection of the exterior skin condition, relevant information includes the type of eruption, color, temperature, foods, activities, climates or emotions that affect the symptoms, details ...
Genome insertions and deletions (indels) show tremendous functional impacts despite they are much less common than single nucleotide variants, which are at the center of studies assessing cancer mutational signatures. We studied 8,891 tumor samples of 32 types from The Cancer Genome Atlas in order to explore those genes which are potentially implicated in cancer indels. Survival analysis identified in-frame indels as the most important variants predicting adverse outcome. Transcriptome-wide association study identified 16 genes overexpressed in both tumor samples and tumor types with high number of in-frame indels, of whom four (APOBEC1, BCL2L15, FOXL1, and PDX1) were identified with gene products distributed within the nucleus ...
I am interested in monitoring, understanding, and preventing the processes that cause human cancer. Previously, I developed the concept of mutational signatures, which I used to reveal the mutational processes in human cancer. My research is based on developing novel mathematical models, implementing these models into computational tools, and applying these tools to already existing biological datasets. If awarded a Packard Fellowship, I propose to develop three novel computational tools and apply these tools to large-scale existing omics data to answer three specific questions in cancer biology: (i) How does alcohol cause cancer? (ii) How can we identify and monitor environmental mutagenic exposures in healthy individuals? (iii) Can we reconstruct and accurately time the molecular evolution of a metastatic cancer? Successfully answering any of these three questions will have wide-spread implications for public health as well as for cancer prevention and cancer treatment.. ...
Genome insertions and deletions (indels) show tremendous functional impacts despite they are much less common than single nucleotide variants, which are at the center of studies assessing cancer mutational signatures. We studied 8,891 tumor samples of 32 types from The Cancer Genome Atlas in order to explore those genes which are potentially implicated in cancer indels. Survival analysis identified in-frame indels as the most important variants predicting adverse outcome. Transcriptome-wide association study identified 16 genes overexpressed in both tumor samples and tumor types with high number of in-frame indels, of whom four (APOBEC1, BCL2L15, FOXL1, and PDX1) were identified with gene products distributed within the nucleus ...
ASPS is a rare sarcoma with limited options in the metastatic setting (8, 9). Both patients 1 and 2 failed to respond to antiangiogenic therapy and after disease progression were placed on either single-agent or combination immune checkpoint inhibitors. Both patients showed substantial and sustained partial responses. Pathologic assessment of IHC and TILs in these patients indicated that the responses to immunotherapy appeared unrelated to baseline numbers of immune cell infiltrates. Exomic characterization demonstrated an MMR deficiency signature, which may, in part, explain these responses; however, conventional MMR aberrations were not identified. Although puzzling, a similar situation has been reported in breast cancer where BRCA mutational deficiency signatures can be identified in patients with no identifiable somatic BRCA mutations (14). The reason for the mutational signature is unclear although was identified in 3 of 5 additional cases where whole-exome sequencing was undertaken. There ...
Researchers use army of organoids to detect distinct mutational signature. A toxin produced by bacteria found in some probiotics - over-the-counter supplements used to treat conditions including irritable bowel and diarrhoea - has been linked to the development of bowel cancer. Writing in the journal Nature, researchers led by Hans Clevers at the Hubrecht Institute in Utrecht,…
Why should we concern ourselves with genetics and mutations in SARS-CoV-2? There are many reasons why these are of interest, including the rate at which mutations are occurring. One reason is that mutations can result in immune evasion. Changes can occur in recognition sites (epitopes) for antibodies and for cytotoxic T cells, and these could, in theory, make vaccines less effective. In fact, our immune response tends to select for exactly these kinds of mutational changes in the virus. Another reason for our interest is that mutational signatures allow us to identify chains of transmission and origins of clusters of related mutants. Comparisons of genome sequences between current and previously circulating strains may allow us to trace the current pandemic back to a common ancestral virus and, perhaps, identify its natural source, making it easier to anticipate and better deal with the next spillover event. Mutations may allow a virus to become more or less virulent or transmissible. ...
Davidson PR, Sherborne AL, Taylor B, Nakamura AO, Nakamura JL. A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies. Sci Rep. 2017;7(1):7645. doi: 10.1038/s41598-017-07888-0. PubMed PMID: 28794481; PMCID: PMC5550450.. Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017;23(7):1852-61. doi: 10.1158/1078-0432.CCR-16-0610. PubMed PMID: 27683180. A.L. Sherborne, P.R. Davidson, K. Yu, A.O. Nakamura, M. Rashid, J.L. Nakamura. Mutational analysis of ionizing radiation-induced neoplasms. Cell Rep. 2015 Sep 22;12(11):1915-26. doi: 10.1016/ j.celrep.2015.08.015. Epub 2015 Sep 3. PMID: 26344771.. R. Mroue, B. Huang, S. Braunstein, A. ...
Alexandrov LB, Kim J, Haradhvala NJ, Huang MNi, Ng AWei Tian, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN et al.. 2020. The repertoire of mutational signatures in human cancer. Nature. 578(7793):94-101. ...
The mutational signature AC3, which has been associated with defects in homologous recombination repair (HRR), was detected in both sporadic meningioma and Mrad, but widely distributed across the genome in sporadic cases and enriched near genomic breakpoints in Mrad. Compared to the other MCs, the number of
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Bismillahirrahmanirrahim... Baiklah, dengan lapang dada saya berusaha mencoba menuliskan sebuah tulisan berjudul norak ini. He. Sebuah pekerjaan rumah yang belum sempat saya kerjakan dari uda Rangtalu. Semoga hasilnya tidak mengecewakan. 8O Aan Jaman Doeloe alias Aan Jadul, PR tentang masa-masa SD seorang Aan. GURU FAVORIT PR sulit ini mah. Pasalnya guru favorit saya adalah semua…
He leaned his head on the back of seat and closed his eyes.. ___. Every Sunday mother used to visit the Chinese herbalist just around the corner for her allergies. She would always take me along. Sometimes the appointment lasted for what seemed like hours. I Would sit in the front room, listening to the herbalists wife calculate bills on her abacus. One Sunday, when the business was specially slow and I was especially bored, the herbalists wife asked, So little friend, what do you plan to become when you grow up ...
Li Ching Yuen was quite the extraordinary man. As a Chinese herbalist, he lived 256 years or 197 by his own account. Either way this is far more than is recognized as the maximum human life span.. ...
Li Ching Yuen was quite the extraordinary man. As a Chinese herbalist, he lived 256 years or 197 by his own account. Either way this is far more than is recognized as the maximum human life span.. ...
1. Dhaenens C. Aristolochia: The malignant lie and the benign truth. J Register Chin Herbal Med 2013;10:39-41. 2. Dhaenens C. Aristolochia - die bösartige Lüge und die gutartige Wahrheit. Naturheilpraxis 2016;69:65-8. 3. Debelle FD, Vanherweghem JL and Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008;74:158-69. 4. De Broe ME. On a nephrotoxic and carcinogenic slimming regimen. Am J Kidney Dis 1999;33:1171-3. 5. Wiebrecht A. Über die Aristolochia-Nephropathie. Dt Zschr Akupunktur 2000;43:187-97. 6. Gökmen MR, Cosyns JP, Arlt VM, et al. The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review. Ann Intern Med 2013;158:469-77. 7. Pena JM, Borras M, Ramos J and Montoliu J. Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 1996;11:1359-60. 8. Yang L, Su T, Li XM, et al. Aristolochic acid nephropathy: variation in presentation and ...
1. Dhaenens C. Aristolochia: The malignant lie and the benign truth. J Register Chin Herbal Med 2013;10:39-41. 2. Dhaenens C. Aristolochia - die bösartige Lüge und die gutartige Wahrheit. Naturheilpraxis 2016;69:65-8. 3. Debelle FD, Vanherweghem JL and Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008;74:158-69. 4. De Broe ME. On a nephrotoxic and carcinogenic slimming regimen. Am J Kidney Dis 1999;33:1171-3. 5. Wiebrecht A. Über die Aristolochia-Nephropathie. Dt Zschr Akupunktur 2000;43:187-97. 6. Gökmen MR, Cosyns JP, Arlt VM, et al. The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review. Ann Intern Med 2013;158:469-77. 7. Pena JM, Borras M, Ramos J and Montoliu J. Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 1996;11:1359-60. 8. Yang L, Su T, Li XM, et al. Aristolochic acid nephropathy: variation in presentation and ...
Acute uric acid nephropathy (AUAN, also acute urate nephropathy) is a rapidly worsening (decreasing) kidney function (renal insufficiency) that is caused by high levels of uric acid in the urine (hyperuricosuria). Acute uric acid nephropathy is usually seen as part of the acute tumour lysis syndrome in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as leukemia and lymphoma. It may also occur in these patients before treatment is begun, due to spontaneous tumor cell lysis (high incidence in Burkitts lymphoma). Acute uric acid nephropathy can also be caused by an acute attack of gout. Acute uric acid nephropathy is caused by deposition of uric acid crystals within the kidney interstitium and tubules, leading to partial or complete obstruction of collecting ducts, renal pelvis, or ureter. This obstruction is usually bilateral, and patients follow the clinical course of acute renal failure. The picture of acute renal failure is ...
A simple and rapid capillary zone electrophoresis (CZE) method for the determination of aristolochic acid (AA) in dietary supplements and selected herbs is described. A clear separation of AA from other sample constituents was achieved within 5 minutes without any sample clean up. A mixture of 20 mM-morpholinethanesulphonic acid+10 mM-BisTrisPropane+0.2% hydroxyethylcelullose in 10% methanol serves as a background electrolyte. The linearity, accuracy, intra-assay and detection limit of the developed method are 200-6000 ng/mL, 95-103%, 3.5%, and 50 ng/ml, respectively. Ease of use, sufficient sensitivity and low running cost are the most important attributes of the CZE method. The proposed CZE method was compared with HPLC ...
In previous reports, more than 100 phytochemical compounds of different Aristolochia species have been analyzed with their biological activities (Kuo et al., 2012; Wu et al., 2004), but total phytochemical study of the root, stem, leaf, and fruit of A. clematitis and other species of the genus has not been carried out. Aristolochia species showed antibacterial and antifungal effects against various microorganisms, such as Aristolochia indica against S. aureus, Staphylococcus epidermidis, Bacillus megaterium, E. coli, Salmonella Typhi, and Vibrio cholerae (Farhana et al., 2016), Aristolochia bracteolata for Aspergillus flavus and Botrytis cinerea (Trayee et al., 2016), or A. trilobata, A. brevipes, Aristolochia monticola Brandegee and Aristolochia kristsagathra against S. aureus (Camporese et al., 2003; Moorthy et al., 2015; Murillo-Alvarez et al., 2001). Among the identified compounds, such as 7,9 dimethoxytariacuripyrone, licarin A and B have antimicrobial effect out of AAs (Kuo et al., ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. New report on global Urinary Tract Cancer market is segmented on the basis of types, diagnostic techniques, treatment procedures and geography. On the basis of types urinary tract cancer market is further categorized into Urothelial carcinoma, Squamous cell carcinoma, Adenocarcinoma and others. Among the urinary tract cancer types, urothelial carcinoma is the most-prevalent with ~90% to 95% occurrence rate, globally. Based on diagnostic techniques it is segmented into Cystoscopy, Urine analyses, Transurethral resection of tumor and Imaging tests. Being a part of initial evaluation in diagnosis of any urinary tract cancer, cytoscopy is the most important investigation for bladder cancer. Segmentation on the basis of treatment procedures categorizes the market into Surgery, Intravesical therapy, Chemotherapy, and Radiation therapy. Geographically, the global urinary tract cancer market is segmented into North ...
It has been well established that the formation of reactive metabolites of drugs is associated with drug toxicity. Similarly, there are accumulating data suggesting the role of the formation of reactive metabolites/intermediates through bioactivation in herbal toxicity and carcinogenicity. It has been hypothesized that the resultant reactive metabolites following herbal bioactivation covalently bind to cellular proteins and DNA, leading to toxicity via multiple mechanisms such as direct cytotoxicity, oncogene activation, and hypersensitivity reactions. This is exemplified by aristolochic acids present in Aristolochia spp, undergoing reduction of the nitro group by hepatic cytochrome P450 (CYP1A1/2) or peroxidases in extrahepatic tissues to reactive cyclic nitrenium ion. The latter was capable of reacting with DNA and proteins, resulting in activation of H-ras oncogene, gene mutation and finally carcinogenesis. Other examples are pulegone present in essential oils from many mint species; and teucrin A, a
In the present study, we elucidated whether all hTAS2R genes are expressed in gustatory tissue and, hence, whether the entire hTAS2R gene family might serve as taste receptors. Previous studies demonstrated that all functionally analyzed TAS2Rs respond to substances known to taste bitter to humans [hTAS2R4, denatonium benzoate (Chandrashekar et al., 2000); hTAS2R7, strychnine (Sainz et al., 2007); hTAS2R10, strychnine (Bufe et al., 2002); hTAS2R14, picrotoxin (Behrens et al., 2004); hTAS2R16, salicin (Bufe et al., 2002); hTAS2R38, 6-n-propyl-2-thiouracil (Kim et al., 2003; Bufe et al., 2005); hTAS2R43/44, aristolochic acid (Kuhn et al., 2004); hTAS2R47, 6-nitrosaccharin (Pronin et al., 2004); only single compounds listed for each receptor] or aversive to rodents [mouse T2R5, cycloheximide; mouse T2R8, denatonium benzoate (Chandrashekar et al., 2000); rat T2R9, cycloheximide (Bufe et al., 2002)]. These findings support the conclusion that most likely all TAS2Rs are indeed bitter sensors. However, ...
Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 1: The agent (mixture) is carcinogenic to humans. The exposure circumstance entails exposures that are carcinogenic to humans. This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent (mixture) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient but there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity. 2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, and plants containing them Arsenic and inorganic arsenic compounds1 Asbestos Azathioprine Benzene Benzidine, and dyes metabolized to Benzo[a]pyrene Beryllium and beryllium compounds2 Chlornapazine ...
Earlier this week, the U.S. Department of Health and Human Services (HHS) added eight substances to its Report on Carcinogens. The 12th Report on Carcinogens now includes a grand total of 240 listings. HHS added formaldehyde and aristolochic acids as known human carcinogens and listed captafol, cobalt-tungsten carbide (in powder or hard metal form), certain inhalable glass wool fibers, o-nitrotoluene, riddelliine, and styrene as substances that are reasonably anticipated to be human carcinogens.. The report was prepared for HHS by the National Toxicology Program (NTP). It identifies agents, substances, mixtures, or exposures in two categories, (a) known to be a human carcinogen, and (b) reasonably anticipated to be a human carcinogen. That said, whether known or anticipated, the development of cancer really depends on exposure and individual susceptibility.. Considering the focus of this site - sustainable homes, natural materials, and green technology - readers should pay attention to the ...
found in cocoa).1 Herbs containing aristolochic acid actually do cause cancer, because they contain enough of it to be harmful. Cocoa, on the other hand, contains such a small amount of safrole that it is harmless. Its all about the amounts. The dose makes the poison. California requires certain products to have labels saying This product contains chemicals known to the State of California to cause cancer and birth defects or other reproductive harm. This is a completely useless statement. Its irrelevant whether something contains carcinogens; whats important is whether it contains enough of it to be dangerous. Somebody on Slashdot once joked that when theyre a billionaire, theyll launch a blimp to block out the sun that says: The sun is known to the state of California to cause cancer - which is perfectly true! You can write entire articles on the supposed evils of any substance by stating scary facts. (The DHMO hoax very skilfully parodied this kind of chemophobic fear mongering.) For ...
Dong, W.; Matsumura, F.; Kullman, S.W. (2010). TCDD induced pericardial edema and relative COX-2 expression in medaka (Oryzias latipes) embryos. Toxicol. Sci. 118 (1), 213-223.. Fujisaw, N.; Nakayama, S.M.M.; Ikenaka, Y.; Ishizuka, M. 2014. TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398. Arch. Toxicol. 88, 1739-1748.. Huang, C.C.; Chen, P.C.; Huang, C.W.; Yu, J. (2007). Aristolochic acid induces heart failure in zebrafish embryos that is mediated by inflammation. Toxicol. Sci. 100, 486-494.. Teraoka, H.; Kubota, A.; Kawai, Y.; Hiraga, T. (2008). Prostanoid signaling mediates circulation failure caused by TCDD in developing zebrafish. Interdis. Studies Environ. Chem. Biol. Resp. Chem. Pollut. 61-80.. Teraoka, H.; Okuno, Y.; Nijoukubo, D.; Yamakoshi, A.; Peterson, R.E.; Stegeman, J.J.; Kitazawa, T.; Hiraga, T.; Kubota, A. (2014). Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquat. Toxicol. ...
* found in: Biapenem, Astilbin, Allicin, aqueous solution, Aristolochic Acid B, Aflatoxin B2, Antimycin A, Aflatoxin M1, 7-Aminoactinomycin D, Aztreonam,..
0137] The at least one used anti-inflammatory, antiproliferative, antiangiogenic, antirestenotic (anti-restenosis), antineoplastic, antimigrative and/or antithrombogenic active agent is preferably selected from the group comprising or consisting of: abciximab, acemetacin, acetylvismione B, aclarubicin, ademetionine, adriamycin, aescin, afromosone, akagerine, aldesleukin, amidorone, aminoglutethimide, amsacrine, anakinra, anastrozole, anemonin, anopterine, antimycotics, antithrombotics, apocymarin, argatroban, aristolactam-All, aristolochic acid, ascomycin, asparaginase, aspirin, atorvastatin, auranofin, azathioprine, azithromycin, baccatin, bafilomycin, basiliximab, bendamustine, benzocaine, berberine, betulin, betulinic acid, bilobol, bisparthenolidine, bleomycin, bombrestatin, Boswellic acids and its derivatives, bruceanol A, B and C, bryophyllin A, busulfan, antithrombin, bivalirudin, cadherins, camptothecin, capecitabine, o-carbamoyl-phenoxyacetic acid, carboplatin, carmustine, celecoxib, ...
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Over thousands of years of clinic practice, CM showed assured effectiveness for ESRD (end stage kidney disease). And yet why people still believe the rumor saying Chinese herb containing element that would damage the kidney or Chinese Herb Nephropathy (CHN
For the most accurate results, please enter a full postcode into the search box so we can determine your exact location. If you type in a town name or the first part of a postcode the results will be ordered by distance from the centre of that town.. ...
For the most accurate results, please enter a full postcode into the search box so we can determine your exact location. If you type in a town name or the first part of a postcode the results will be ordered by distance from the centre of that town.. ...
You might recognize this as an amazingly large-flowered specimen of the group of vines known as Dutchmans pipes, or birthworts, genus Aristolochia, often grown in gardens, and with native species occurring in much of North America and the tropics. This giant-flowered species is ARISTOLOCHIA GRANDIFLORA, commonly called Brazilian Dutchmans Pipe or Giant Pelican Flower. Its a member of the Dutchmans Pipe or Birthwort Family, the Aristolochiaceae, native to Central and South America, but planted in the tropics and subtropics worldwide. Instead of the flowers consisting of the usual calyx and corolla, they produce a corolla-like calyx, or perianth. The perianths unusual U-shaped tubes helps the flower with its pollination. The blossoms strong fragrance entice insects, mostly flies, to enter the yellow opening, and descend the tube. In the above picture you can see that the tube constricts at its bottom, then opens into a larger chamber. This makes it harder for the pollinator to find the way ...
Cancer is when cells in the body grow out of control, often forming a mass or tumor. In upper urinary tract cancer, abnormal cells are found in the renal pelvis, renal calyces and/or ureters.
Cancers arise through the process of somatic evolution fueled by the inception of somatic mutations. We lack a complete understanding of the sources of these somatic mutations. Humans host a vast repertoire of microbes collectively known as the microbiota. The microbiota plays a role in altering the tumor microenvironment and proliferation. In addition, microbes have been shown to elicit DNA damage which provides the driver for somatic mutations. An understanding of microbiota-driven mutational mechanisms would contribute to a more complete understanding of the origins of the cancer genome. Here, we review the modes by which microbes stimulate DNA damage and the effect of these phenomena upon the cancer genomic architecture, specifically in the form of mutational spectra and mutational signatures ...
Hypermutated tumors with POLE germline mutations have been described in patients with colorectal cancer (15), and somatic alterations in POLE were recently reported in subsets of patients with glioblastomas and endometrial cancers (14, 27). To our knowledge, our report represents a description of only the second reported adult patient with glioblastoma in the setting of germline POLE deficiency (28). POLE encodes the DNA polymerase ε catalytic subunit, which synthesizes and proofreads leading strand DNA. In this report, the germline POLE alteration was likely permissive in creating an unstable genomic context that facilitated additional abundant somatic DNA-repair machinery alterations. However, the level of hypermutation makes it difficult to clearly assign causality to mutated POLE alone, based on the observed mutational signatures.. The relationship between neoantigen burden and checkpoint blockade therapy response has been described in other tumor types but has not been reported extensively ...
Summary DNA repair pathways evolved as an intricate network that senses DNA damage and resolves it in order to minimise genetic lesions and thus preventing tumour formation. Gaining in recognition the last few years, the alternative end-joining (alt-EJ) DNA repair pathway was recently shown to be up-regulated and required for cancer cell viability in the absence of homologous recombination-mediated repair (HR). Despite this integral role, the alt-EJ repair pathway remains poorly characterised in humans. As such, its molecular composition, regulation and crosstalk with HR and other repair pathways remain elusive. Additionally, the contribution of the alt-EJ pathway to tumour progression as well as the identification of a mutational signature associated with the use of alt-EJ has not yet been investigated. Moreover, the clinical relevance of developing small-molecule inhibitors targeting players in the alt-EJ pathway, such as the polymerase Pol Theta (Polθ), is of importance as current anticancer ...
To identify prognostic markers in CLL, a robust IGVH mutational signature was generated and used to infer its upstream TFs through mutual information networks and master regulator analysis. Given the large number of samples used and the heterogeneous spectrum of genomic aberrations represented, the integrated information allowed us to bring together various molecular events that underlie CLL and to compare patients only by their IGVH mutational status.. Because the IGVH mutational status is a good survival predictor, genes that are differentially expressed in mutated versus unmutated subtypes are also meaningful in prognosis. The top differentially expressed genes found in this study have been previously associated with IGVH status [7-9]. Genes such as LPL, CRY1, ZBTB20, SEPT10, COBLL1, NRIP1, DMD, LDOC1, and ZAP70 were found in the top DE list and have been shown to have CLL prognostic value [41, 42].. The differentially expressed genes between the IGVH subtypes were preferentially enriched ...
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Aristolochia debilis is a PERENNIAL growing to 1 m (3ft 3in) by 1 m (3ft 3in). It is hardy to zone (UK) 8. It is in flower from July to August, and the seeds ripen from September to October. The species is hermaphrodite (has both male and female organs) and is pollinated by Flies. Suitable for: light (sandy), medium (loamy) and heavy (clay) soils and prefers well-drained soil. Suitable pH: acid, neutral and basic (alkaline) soils. It can grow in semi-shade (light woodland) or no shade. It prefers moist soil.
Aristolochia debilis is a PERENNIAL growing to 1 m (3ft 3in) by 1 m (3ft 3in). It is hardy to zone (UK) 8. It is in flower from Jul to August, and the seeds ripen from Sep to October. The flowers are hermaphrodite (have both male and female organs) and are pollinated by Flies.Suitable for: light (sandy), medium (loamy) and heavy (clay) soils and prefers well-drained soil. Suitable pH: acid, neutral and basic (alkaline) soils. It can grow in semi-shade (light woodland) or no shade. It prefers moist soil.
23. Aristolochia forrestiana J. S. Ma, Acta Bot. Yunnan. 11: 321. 1989. 大囊马兜铃 da nang ma dou ling Shrubs climbing. Stems terete, striate, glabrous. Petiole 2-3 cm, glabrous; leaf blade ovate to narrowly ovate, 9-13 × 3-5 cm, leathery, both surfaces glabrous, veins palmate, 6-8 pairs from base, base cordate, sinus 1.5-2 × 1-2 cm, apex acute. Flowers in axils of leafy shoots, solitary. Peduncle pendulous, 5-7 cm, pubescent; bractlets ovate or subulate, inserted near middle of peduncle. Calyx purple; tube geniculately curved, abaxially pubescent; basal portion of tube 15-20 × ca. 5 mm; limb saccate, asymmetric, ca. 6 × 1.5 cm, 3-lobed; lobes lanceolate, ca. 25 × 10 mm. Anthers not seen. Gynostemium 3-lobed. Fruit not seen.. * Yunnan.. ...
Find help and information on Aristolochia californica California Dutchmans pipe Dutchmans pipe vine California pipevine, including varieties and pruning advice. Click here to find out more.
Discover Lifes page about the biology, natural history, ecology, identification and distribution of Aristolochia inflata capsule image
Researchers from Hong Kong, China, and Englands University of Birmingham evaluated the effects of Chinese herbal medicine prescribed by a trained herbalist on 120 patients with early-stage breast or colon cancer. Each patient was assigned to one of three Chinese herbalists to have their needs assessed. One group received a Chinese herbal treatment based on their individual needs, while the other group received an inactive placebo ...
256 Year Old Chinese Herbalist Li Ching-Yuen, Holistic Medicine, and 15 Character Traits That Cause Diseases JUNE 25, 2013 The herbalist had 23 wives and rais
Polyrhachis Ant is a safe, natural and nutritional dietary supplement used for centuries by Chinese herbalists and nobles. It is regarded as the Herb of Kings in the Chinese Medicinal Classic called Ben Cao Gang Mu which was written by Legendary Herbalist Li Chi Zhen.
Promotes healthy digestive system. All veterinary new vita® herbal supplements are developed by Traditional Chinese Medicine (TCM) formulations of Dr. Luke Cua and manufactured by American Herbal Laboratories in the USA, an FDA-registered, GMP-certified facility. Dr. Cua is a National Board Certified in Chinese Herbalist & Acupuncturist who pioneered in integrative TCM and nanotechnology since 1983. upset stomach, supplement
Triple Leaf Teas made by a Chinese-American family business combines ancient Chinese herbal formulas with modern day Chinese herbalists trained in healing herbalism. The result is the creation of these delicious healing teas to meet modern-day needs.
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While the old guard of traditional medics still talk about the placebo effects of New Age practices, many of their younger colleagues are working after hours to gen up on all there is to know about acupuncture meridian points, for example.. If nothing else, they know they have to keep up if they dont want to lose chunks of their younger clientele to Chinese herbalists and the like.. The whole question of placebo effects could take up a whole book, of course. Doesnt the very idea of it prove that we can control our body with our beliefs?. But thats another story.. Here I want to talk about chakras. These are the energy hot spots on the body which run along the meridian lines - the lines used in acupunture.. In 1998, acupunture was investigated by the US Food And Drug Administration and found to work as well as or better than traditional Western medicine for a vaiety of ailments.. And thats the way with so much so-called alternative medicine.. People with bad backs are reporting ...
Alexa Gilmore is a vitality warrior who takes a stand for your fullest potential. As an acupuncturist, Chinese herbalist, bodyworker, and coach, she takes a no-nonsense approach to the healing arts and expects positive outcomes: function rebalanced, harmony restored, resilience renewed. She welcomes guests from around the county to her clinic in Portland, Maine, where she specializes in chronic illness, womens health, and skin disease, but her passion is to use optimal health as a vehicle for personal transformation. Playing Small Moment After months of seeing her maximum amount of patients each day, Alexa suddenly realized there was more she wanted to accomplish. Alexa knew that if she could get her hands on people uninterrupted for as many hours per day, magic would happen. So, why did she feel that it wasnt possible? This helped her come to a realization about who she was and what she wants to offer the world. Style of Leadership Alexa starts off as a guide for her clients and patients, to help
25 yrs experienced Acupuncturist & Chinese Herbalist in NYC, Olivia Wan-Mei Woo; treatments for infertility, migraine, allergies, carpal, tunnel, back pain
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Sometimes a treatment may be started at a lower dose or the dose needs to be changed during treatment. There may also be times when your treatment is delayed. This can happen if your doctor thinks you are likely to have severe side effects, if you get severe side effects, if your blood counts are affected and causing delays in treatment, or if you are finding it hard to cope with the treatment. This is called a dose reduction, dose change or treatment delay. Your doctor will explain if you need any changes or delays to your treatment and the reason why. ...
If the body is unable to naturally buffer acidity, it will use the calcium and magnesium stored in our bones to neutralize the extra acid, or it will produce ammonia (which is a base) from our muscles to use as a neutralizer. Once the neutralizing response is complete, the minerals (from our now-compromised bone and broken-down muscles) are excreted into the urine.. As the process continues, the body may also try to buffer acids by releasing chloride molecules from the cells. Chloride usually attaches to minerals such as calcium or magnesium (which form mineral salts that are deposited in our tissues). At first, there may not be any signs or symptoms of this chloride release, but soon the aches and pains begin and energy declines. Add to the mix salts formed by other acids (i.e., uric acid) that may also end up in joints and cartilage, and you wind up with additional stiffness and pain.. Acidity may also lead to compromised oxygen delivery. Why? According to Dr. Dan, if you are acidic, oxygen ...
Because it consists of monomer building blocks. A polymer is a large molecule that is built up from multiple smaller building blocks in a repetitive manner. The building blocks of the nucleic acids DNA and RNA are nucleotides (see image). The nucleotides have a phosphate group, a sugar group and a nitrogenous base (adenine, thymine, guanine, cytosine or uracil). Many of these building blocks bound together for the nucleic acid i.e. the polymer: This is an example of a double-stranded nucleic acid = DNA. It can also be a single strand = RNA. Both DNA and RNA are polymers.
However one of the products has hydrolyzed silk amino acids and another one has silk amino acids I am not sure if that would be conducive for someone that is protein senstive I know that I can use products with Hydrolyzed wheat starch (curls sublime condish has it for the 13th or 14th ingredient) But that is the only one that I know of that I can use without a problem Get More ...
SARS-CoV-2 pediatric viral load. A letter in JAMA Pediatrics this week reported an analysis of the nasopharyngeal viral nucleic acid amount in 145 patients testing positive for COVID-19 in Chicago, grouping them by age. Amount of nucleic acid present was estimated by using the PCR amplification cycle threshold value for a given nasopharyngeal swab, with lower cycle threshold (CT) values indicating higher amounts of viral nucleic acid (i.e. fewer PCR cycles were needed to amplify the nucleic acid present in order to reach the detectable threshold). Patients with severe infection were excluded as they are known to have higher viral nucleic acid amounts, so 7 children requiring supplemental oxygen were excluded. Asymptomatic patients were also excluded, as were those with symptoms for more than 1 week prior to testing or unknown duration of symptoms. The cohort of 46 children under age 5 was compared to a cohort of 51 children aged 5 to 17 years and 48 adults aged 18 to 65. While the latter cohorts ...
Disclosed are compositions and a method for of amplifying nucleic acid sequences useful for detecting the presence of molecules of interest. The method is useful for detecting specific nucleic acids i
... aristolochic acid. Even though aristolochic acid has been found to expedite and arouse the activity of white blood cells, speed ... Aristolochic acid is a very dangerous compound in that this acid is a potent mutagen and carcinogen that can cause urological ... Consumption of aristolochic acid can also induce uterine bleeding. Because of this, the FDA has warned consumers to avoid ... "Herb Danger - Aristolochic Acid Warning." MedicineNet. Web. 2014-05-05. [1] "Wild Edible and Medicinal Plants". Retrieved 2014- ...
Since aristolochic acid has low water solubility, water decoction is believed to be a safer route than taking guang fang ji as ... "A Success Story on Aristolochic Acid". July 2001. Chen JK, Chen TT (2004). Chinese Medical Herbology and Pharmacology. City of ... In May, 2000, the FDA began detaining any plants or medicines suspected of containing aristolochic acid, unless laboratory ... the resultant guang fang ji preparations can contain toxic amounts of aristolochic acid Ingestion can lead to renal failure and ...
Aristolochic acid was linked to aristolochic acid-associated urothelial cancer in a Taiwanese study in 2012. In 2013, two ... Metabolites of aristolochic acid enter the cell nucleus and form adducts on DNA. While adducts on the transcribed DNA strand ... 2009) Aristolochic acid nephropathy: An environmental and iatrogenic disease. In: Fishbein, J. C. (ed.) Advances in Molecular ... 2012). "Aristolochic acid-associated urothelial cancer in Taiwan". Proceedings of the National Academy of Sciences. 109 (21): ...
However, they are of little medicinal value and contain the carcinogen aristolochic acid. The over-use of this plant family in ... β-aminobutyric acid, γ-aminobutyric acid, ephedrine, trigonelline, phytosterols and glucoronic acid. Care should be taken as ... "Aristolochic acid-associated urothelial cancer in Taiwan". Proceedings of the National Academy of Sciences. 109 (21): 8241-8246 ... The bark of white willow contains salicin, which is a chemical similar to aspirin (acetylsalicylic acid). It is thought to be ...
"Aristolochic Acid: FDA Warns Consumers to Discontinue Use of Botanical Products that Contain Aristolochic Acid". US FDA. 11 ... The plant contains aristolochic acid, a carcinogenic compound. The United States Food and Drug Administration warns that ... consumption of aristolochic acid-containing products is associated with "permanent kidney damage, sometimes resulting in kidney ...
The plant contains aristolochic acid, a carcinogenic compound. The United States Food and Drug Administration warns that ... but should not be used as a substitute because it contains an unknown concentration of the carcinogen aristolochic acid and ... consumption of aristolochic acid-containing products is associated with "permanent kidney damage, sometimes resulting in kidney ...
By eating some of these toxic plants, the caterpillars sequester aristolochic acid which renders both the caterpillars and the ... von Euw, J.; Reichstein, T. & Rothschild, M. (1968). "Aristolochic acid in the swallowtail butterfly Pachlioptera aristolochiae ...
Many closely related natural product alkaloids are known including aristolochic acid and its lactam derivatives. In some ... and are related to aristolochic acid. Piperolactam A was first reported in 1988 after isolation from an extract of Piper longum ... aristolochic acids and dioxoaporphines and their biological activities". Natural Product Reports. 20 (6): 565-83. doi:10.1039/ ... "Naturally occurring aristolochic acid analogues and their toxicities". Natural Product Reports. 31 (5): 676-93. doi:10.1039/ ...
This plant contains aristolochic acid, a toxic alkaloid. The vining plant is native to southern and western South America. It ... Aristolochia littoralis prefers acid-neutral soils (pH 5.5 - 7.0) and average moisture, in part sun to shade, at an elevation ...
The plant contains a toxic substance, aristolochic acid. The larvae sequester the toxin, and both the juvenile and adult ... doi:10.1046/j.0021-8790.2001.00568.x. Fordyce, James A. (2000). "A model without mimic: Aristolochic acids from the California ... butterflies have high and toxic concentrations of the aristolochic acid in their tissues. Throughout the range of the species, ...
Aristolochic acid, a compound found in plants of the family Aristolochiaceae, also causes DNA mutations and is a cause of liver ... "Mutation signatures implicate aristolochic acid in bladder cancer development". Genome Medicine. 7 (1): 38. doi:10.1186/s13073- ...
The link between kidney failure and aristolochic acid, which the plant contains, was discovered after a clinic for obesity in ... Broe, M. E. D. (2012). "Chinese herbs nephropathy and Balkan endemic nephropathy: Toward a single entity, aristolochic acid ... "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proceedings of the National Academy of Sciences. 104 (29 ...
Some phytochemicals are known phytotoxins that are toxic to humans; for example aristolochic acid is carcinogenic at low doses ... which include phenolic acids, flavonoids, and stilbenes/lignans. Flavonoids can be further divided into groups based on their ...
Dietary exposure to aristolochic acid is the cause of BEN and its attendant transitional cell cancers. Former hypotheses that ... 2007). "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proc. Natl. Acad. Sci. U.S.A. 104 (29): 12129-34. ... 2007). "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proc. Natl. Acad. Sci. U.S.A. 104 (29): 12129-34. ... It is caused by small long-term doses of aristolochic acid in the diet. The disease primarily affects people 30 to 60 years of ...
Being in the family Aristolociaceae, Aristolochia chilensis contain aristolochic acid. This has typically been used in ... However, the use of this acid for medicinal purposes has been banned in Europe since 2001 and China in 2003 due to studies ... Caterpillars can especially tolerate the acids contained within the plant and, in turn, cause them to become poisonous to ... showing that the acids are carcinogenic, mutagenic, and nephrotoxic, thus causing much more harm then good. Although they do ...
2012 Aristolochic Acid, FDA Recall of Herbs and Herbal Products. January 2001 Mayway Sotore Herbal Archived February 24, 2012, ... Caution is required; injuries are linked to aristolochic acid contained in some species of this family, as in Belgium incorrect ...
... contains the carcinogenic chemical compounds aristolochic acid and derivatives. The plant also contains ...
Aristolochic acid presence may also act as an oviposition chemical stimulant. The pipevine swallowtail larva has few natural ... the level of acid in the body of the butterflies rises as the acid accumulates. High levels of acid make the larvae and adults ... As a result of bird predation, this butterfly has evolved a chemical defense using the aristolochic acids found in their host ... All host plants for the pipevine swallowtail have some form of aristolochic acids, which the larva sequesters while they feed. ...
A. rotunda contains aristolochic acids which are carcinogenic, mutagenic, and nephrotoxic. Aristolochia rotunda subsp. rotunda ... Eating the leaves of the plant the larvae this insect ingest aristolochic acid that make them poisonous to birds. This plant is ... "Plants Containing Aristolochic Acid" (PDF). International Agency for Research on Cancer. Cite journal requires ,journal= (help ...
Plants of the family Aristolochiaceae contain aristolochic acids in their leaves and stems. This is believed to be a potent ...
"Aristolochic Acid: FDA Concerned About Botanical Products, Including Dietary Supplements, Containing Aristolochic Acid". FDA. ...
Members of the family Aristolochiaceae contain aristolochic acid, which has been recognized as a carcinogen. In a study on its ... Schaneberg, B. T.; Applequist, W. L.; Khan, I. A. (2002). "Determination of aristolochic acid I and II in North American ...
"Aristolochic Acid: FDA Warns Consumers to Discontinue Use of Botanical Products that Contain Aristolochic Acid". U.S. Food and ... The FDA warns against consuming Asarum, as it is nephrotoxic and contains the potent carcinogen aristolochic acid. The ... "Determination of aristolochic acid I and II in North American species of Asarum and Aristolochia". Pharmazie. 57 (10): 686-9. ...
15 (1): 5-8.CS1 maint: uses authors parameter (link) Tian-Shung Wu, Yann-Lii Leu and Yu-Yi Chan (2000). Aristolochic Acids as a ... and they sequester toxins such as aristolochic acid in their bodies. This makes the adults toxic to vertebrate predators such ...
Not to be confused with other "snakeroot" plants such as Aristolochia serpentaria (contains toxic aristolochic acids; also ...
Ingestion of aristolochic acid present in many Chinese herbal medications has been shown to cause urothelial carcinoma and ... Aristolochic acid activates peroxidase in the urothelium and causes transversion mutation in the TP53 tumor suppressor gene. ... Yang HY, Chen PC, Wang JD (2014). "Chinese herbs containing aristolochic acid associated with renal failure and urothelial ... Health, Center for Devices and Radiological (7 October 2019). "Nucleic Acid Based Tests". FDA. Soria F, Droller MJ, Lotan Y, ...
The use of this plant poses a risk as it contains the toxin aristolochic acid which is carcinogenic. The USDA has banned all ... "Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on ... and aristolochia group of alkaloids with nucleic acid structures and biological perspectives". Medicinal Research Reviews. 27 ( ...
... aristolactam I and aristolochic acids (I & II) fromAristolochia indica". Natural Product Research. 28 (17): 1413-1417. doi: ...
Stiborová M, Frei E, Sopko B, Wiessler M, Schmeiser HH (April 2002). "Carcinogenic aristolochic acids upon activation by DT- ...
Aristolochic acid is composed of an about 1:1 mixture of two forms, aristolochic acid I and aristolochic acid II. In addition ... The plant has a number of historical medicinal uses.[vague] This plant contains aristolochic acid, a carcinogen also found in ... However, despite these well-documented dangers, aristolochic acid still is present sometimes in herbal remedies (such as for ... aristolochic acid is also highly nephrotoxic and may be a causative agent in Balkan nephropathy. ...
2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... analgesic mixtures containing Plants containing aristolochic acid Polychlorinated biphenyls, dioxin-like Processed meats, ... strong-acid process) Glass, making of Magenta dyes, manufacture of Painting (see benzene) Paving and roofing with coal tar ... occupational exposure associated with Acid mists, strong inorganic Aluminium production Auramine production Boot and shoe ...
Plants of the family Aristolochiaceae contain aristolochic acids in their leaves and stems. This is believed to be a potent ...
Some phytochemicals are known phytotoxins that are toxic to humans;[14][15] for example aristolochic acid is carcinogenic at ... which include phenolic acids, flavonoids, and stilbenes/lignans.[5] Flavonoids can be further divided into groups based on ...
Aristolochic acid was linked to aristolochic acid-associated urothelial cancer in a Taiwanese study in 2012.[28] In 2013, two ... 2009) Aristolochic acid nephropathy: An environmental and iatrogenic disease. In: Fishbein, J. C. (ed.) Advances in Molecular ... Cosyns, J. P. (2003). "Aristolochic acid and 'Chinese herbs nephropathy': a review of the evidence to date". Drug Saf. 26 (1): ... July 1999). "Aristolactam I a metabolite of aristolochic acid I upon activation forms an adduct found in DNA of patients with ...
Aristolochic acids are metabolized by oxidation and reduction pathways, or phase I metabolism. Reduction of aristolochic acid I ... aristolochic acid I (AA-I) and aristolochic acid II (AA-II). The biosynthesis of these compounds has been of considerable ... Since aristolochic acid is a mutagen, it does damage over time. Patients are often first diagnosed with aristolochic acid ... containing aristolochic acid.[24] The agency warned that consumption of aristolochic acid-containing products was associated ...
The feeding caterpillars incorporate and concentrate the aristolochic acid into their tissues, where the poison will persist ... the vines which the caterpillars feed upon contain aristolochic acid, a poisonous compound known to be carcinogenic in rats. ...
... found in alcoholic beverages Aflatoxins 4-Aminobiphenyl Aristolochic acids, and plants containing them Arsenic and inorganic ... analgesic mixtures containing Plants containing aristolochic acid Polychlorinated biphenyls, dioxin-like, with a Toxicity ... strong-acid process) Glass, making of Magenta dyes, manufacture of Painting (see benzene) Paving and roofing with coal tar ... occupational exposure associated with Acid mists, strong inorganic Aluminium production Auramine production Boot and shoe ...
Illustrative of the myriad pathways to MGO, aristolochic acid caused 12-fold increase of methylglyoxal from 18 to 231 μg/mg of ... Li, YC; Tsai, SH; Chen, SM; Chang, YM; Huang, TC; Huang, YP; Chang, CT; Lee, JA (2012). "Aristolochic acid-induced accumulation ... an important and novel pathway in the pathogenic mechanism for aristolochic acid nephropathy". Biochem Biophys Res Commun. 423 ... It is a reduced derivative of pyruvic acid. It is a reactive compound that is implicated in the biology of diabetes. ...
Many members of Aristolochia and some of Asarum contain the toxin aristolochic acid, which discourages herbivores and is known ... Aristolochic Acid, U.S. Food and Drug Administration alerts Health Canada advising not to use products labelled to contain ...
Ochratoxin possibly is not the cause of this nephropathy, and many authors are in favor of aristolochic acid, that is contained ...
Since aristolochic acid is a mutagen, it does damage over time. Patients are often first diagnosed with aristolochic acid ... Excretion of aristolochic acids and their metabolites is through the urine. The exact mechanism of action of aristolochic acid ... Aristolochic acids are metabolized by oxidation and reduction pathways, or phase I metabolism. Reduction of aristolochic acid I ... aristolochic acid I (AA-I) and aristolochic acid II (AA-II). The biosynthesis of these compounds has been of considerable ...
Aristolochic acid-associated urothelial carcinoma. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ... Aristolochic acid-associated urothelial carcinoma. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ... DNA adducts of aristolochic acid II: Total synthesis and site-specific mutagenesis studies in mammalian cells. Nucleic Acids ... Aristolochic acid-associated urothelial cancer in Taiwan. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ...
Aristolochic acid-associated urothelial carcinoma. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ... Aristolochic acid-associated urothelial carcinoma. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ... Aristolochic acid-associated urothelial cancer in Taiwan. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ... Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the ...
The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. Aristolochic acid i... (Source: SafetyLit ... Herbs and hazards: risk of Aristolochic acid nephropathy in Iran - Ardalan MR, Khodaie L, Nasri H, Jouyban A.. Herbs are ... Aristolochic Acids News This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to ... The connection between kidney cancer and the use of aristolochic acid. There is aan apparent link between exposure to ...
Aristolochic acids are metabolized by oxidation and reduction pathways, or phase I metabolism. Reduction of aristolochic acid I ... aristolochic acid I (AA-I) and aristolochic acid II (AA-II). The biosynthesis of these compounds has been of considerable ... Since aristolochic acid is a mutagen, it does damage over time. Patients are often first diagnosed with aristolochic acid ... containing aristolochic acid.[24] The agency warned that consumption of aristolochic acid-containing products was associated ...
Aristolochic Acid in the Etiology of Renal Cell Carcinoma.. Hoang ML1, Chen CH2, Chen PC3, Roberts NJ1, Dickman KG4,5, Yun BH6 ... Aristolochia species used in the practice of traditional herbal medicine contains aristolochic acid (AA), an established human ...
Table 1: Effects of 0.5 mg/kg aristolochic acid sodium (AANa) treatment on p-aminohippuric acid in rabbits . ... Aristolochic acid sodium (AANa, containing 41% AAI and 56% AAII), p-aminobenzoic acid potassium salt (≥99%), and p- ... Figure 1: Plasma concentrations of p-aminohippuric acid (PAH) after iv administration of 0.5 mg/kg aristolochic acid sodium ( ... Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. Chiao-Shih Tseng, Shih-Ming ...
Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. Chiao-Shih Tseng, Shih-Ming ... The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but ... After a single intravenous administration of 0.5 mg/kg aristolochic acid sodium (AANa), rabbits exhibited mild to moderate ... To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, ...
Is anyone else interested in sharing the cost of a GreenScreen assessment of ARISTOLOCHIC ACIDS []? ... Hi! Can I get a quote for a GreenScreen Assessment of ARISTOLOCHIC ACIDS []?. ...
Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid (AA) ... "Aristolochic acid nephropathy, a global health problem" March 19, 2013 https://medicalxpress.com/news/2013-03-aristolochic-acid ... Aristolochic acid nephropathy, a global health problem. March 19, 2013 in Medicine & Health / Diseases, Conditions, Syndromes ... Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid found ...
A systematic assessment of the content of aristolochic acids in the most widely used species is needed to evaluate whether ... Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on ... highlighted the risk of using preparations which contain aristolochic acids. On the other hand anecdotal evidence highlights ...
... is the main compound of the naturally occurring carcinogen aristolochic acid. Previous studies showed that AAI is directly ... Aristolochic Acid Ames Test Tumorigenicity Assay 61st Codon Carcinogenic Form These keywords were added by machine and not by ... Mengs, U., Lang, W. and Poch, J.A., 1982, The carcinogenic action of aristolochic acid in rats, Arch. Toxicol., 51:107CrossRef ... 1989) Aristolochic Acid I Induced Tumors in Wistar Rats Contain Activating Mutations in Codon 61 of the H-ras Protooncogene. In ...
Although aristolochic acid I (AAI), the major component of the natural plant extract AA, might directly cause interstitial ... is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases ... Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN ... Keywords: aristolochic acid; carcinogenicity; mutagenesis; nephrotoxicity; DNA adduct formation aristolochic acid; ...
A ristolochic acids (AAs) are powerful nephrotoxin and human carcinogen associated with chronic kidney disease and upper ... Aristolochic acid I (AA-I) is the most abundant type of the aristolochic acids. Published data suggest that AA-I is a substrate ... Renal elimination of aristolochic acid I in the isolated perfused kidney model. ... A ristolochic acids (AAs) are powerful nephrotoxin and human carcinogen associated with chronic kidney disease and upper ...
Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc. Natl. Acad. Sci. U.S.A. 104, 12129-12134 (2007).. ... Aristolochic acid-associated urothelial cancer in Taiwan. Proc. Natl. Acad. Sci. U.S.A. 109, 8241-8246 (2012).. ... Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing. Sci. Transl. Med. 5, 197ra102 (2013). ... Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus. Aristolochia plants are commonly ...
Aristolochic acid (AA) is a potent nephrotoxin and carcinogen (IARC Group 1) associated with urothelial, hepatobiliary, and ... Abstract 4252: New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean ... New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean patients: Implications ... Abstract 4252: New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean ...
... detection of aristolochic acids in Aristolochia and Asarum species by using a monoclonal antibody against aristolochic acids I ... Feng C, Xie X, Wu M, Li C, Gao M, Liu M, Qi X and Ren J: Tanshinone I protects mice from aristolochic acid I-induced kidney ... Aristolochic acid (AA) is a component present in Chinese herbs (for example Asarum and Aristolochia) from remedies for the ... Wu TK, Wei CW, Pan YR, Cherng SH, Chang WJ, Wang HF and Yu YL: Vitamin C attenuates the toxic effect of aristolochic acid on ...
Singapore, 19 October 2017 - Scientists from Singapore and Taiwan have revealed a decisive link between Aristolochic Acids (AA ... Singapore-Taiwan Team Reveal Link between Many Liver Cancers and Herbal Remedies Containing Aristolochic Acid. ...
2007). Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA 104, 12129-12134.CrossRef ... 2017). Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. Sci ... Enrichment of AT-TA transversion at 5′-CAG-3′ motif is not a unique mutational signature of Aristolochic acid. ... repairing nucleic acid alkylation damage and beyond. J Biol Chem 290, 20734-20742.CrossRefGoogle Scholar ...
Aristolochic acid is an herb used in many varieties of Chinese herbs and health supplements. Interestingly, it also can cause a ... Patients with aristolochic acid toxicity are also prone to developing malignancies of the urinary tract (e.g. bladder cancer). ... ACEi/ARB (13) acid-base (45) acute kidney injury (77) amyloidosis (12) ANCA-associated disease (20) anemia of chronic kidney ...
What is aristolochic acid? Meaning of aristolochic acid medical term. What does aristolochic acid mean? ... Looking for online definition of aristolochic acid in the Medical Dictionary? aristolochic acid explanation free. ... aristolochic acid still is found in products sold in the US.. aristolochic acid. C17H11NO7, an acid derived from Aristolochia, ... aristolochic acid. Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia. aristolochic acid. Pseudomedicine. A ...
Introduction: Aristolochic acid I, a potent human nephrotoxic and carcinogenic compound produced by aristolochia plants, it is ... Abstract:Introduction: Aristolochic acid I, a potent human nephrotoxic and carcinogenic compound produced by aristolochia ... Keywords:Aristolochic acid, flour, fruit, high-performance liquid chromatography, microextraction, urine.. ... A Microextraction Liquid-Chromatographic Determination of Aristolochic Acid I in Urine, Flour, and Aristolochiaceae Fruit. ...
... method for the determination of aristolochic acid (AA) in dietary supplements and selected herbs is described. A clear ... A mixture of 20 mM-morpholinethanesulphonic acid+10 mM-BisTrisPropane+0.2% hydroxyethylcelullose in 10% methanol serves as a ... aristolochic acid food supplement herbs slimming capillary zone electrophoresis aristolochic acid food supplement herbs ... A simple and rapid capillary zone electrophoresis (CZE) method for the determination of aristolochic acid (AA) in dietary ...
... feed exclusively on aristolochic acid (AAs)-containing Aristolochia species (Aristolochiaceae). The distribution of ... PRIESTAP H.A. 1987: Minor aristolochic acids from Aristolochia argentina and mass spectral analysis of aristolochic acids. ... MIX D.B., GUINAUDEAU H. & SHAMMA M. 1982: The aristolochic acids and aristolactams. J. Nat. Prod. 45: 657-665 Go to original ... Sequestration of aristolochic acids from meridic diets by larvae of Battus polydamas archidamas (Papilionidae: Troidini). ...
Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation.. par Pozdzik, Agnieszka ; ... Characterization of cytotoxic effects of aristolochic acids on the vascular endothelium. par Youl, Estelle N H , Husson, Cécile ... Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy. par ... Early proximal tubular injury in experimental aristolochic acid nephropathy:functional and histological studies par Lebeau, ...
Enzymes metabolizing aristolochic acid and their contribution to the development of aristolochic acid nephropathy and ... Selective toxicity of aristolochic acids I and II. Drug Metab Dispos. 2007;35(7):1217-1222.. View this article via: PubMed ... Acute nephrotoxicity of aristolochic acids in mice. J Pharm Pharmacol. 2004;56(2):221-229.. View this article via: PubMed ... Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA. 2007;104(29):12129-12134.. View ...
... is a class of carcinogenic and nephrotoxic nitrophenanthrene carboxylic acids naturally found in Aristolochia plants. These ... Exposure to aristolochic acid I compromises the maturational competency of porcine oocytes via oxidative stress-induced DNA ...
Aristolochic acids. Studies show that aristolochic acids are present in some types of plants. They may increase the risk of ... People may be exposed to aristolochic acids if they eat or drink herbal products (including capsules, extracts, teas and dried ...
Aristolochic acid(313-67-7) Density MSDS Formula Use,If You also need to Aristolochic acid(313-67-7) Other information,welcome ... ChemicalBook provide Chemical industry users with Aristolochic acid(313-67-7) Boiling point Melting point, ... ARISTOLOCHIC ACID (I AND II) 7-Hydroxyaristolochic acid A Aristolochic acid phosphoric acid Ascoric Acid Methoxyacetic acid p- ... ChemicalBook > Product Catalog > Biochemical Engineering > Biological response modifiers > Aristolochic acid Aristolochic acid ...
Keywords: Chinese herbal medicine; Aristolochic acid; Renal toxicity INTRODUCTION. Aristolochic acid (AA)-containing compounds ... AA, aristolochic acid; AAI, 8-methoxy-6-nitro-phenanthro-(3,4-d)-1,3-dioxolo-5-carboxylic acid; AAII, 6-nitro-phenanthro-(3,4-d ... Update of aristolochic acid nephropathy in Korea. Article information. Korean J Intern Med. 2018;33(5):961-969 ... Occurrence of aristolochic acid nephropathy (AAN) and routes for obtaining herbal medicine in Korea. (A) Occurrence of AAN over ...
  • A similar condition previously known as Balkan endemic nephropathy (BEN), first characterized in the 1950s in southeastern Europe, was later discovered to be also the result of aristolochic acid (AA) consumption. (wikipedia.org)
  • CHN and BEN fall under the umbrella of what is now known as aristolochic acid nephropathy, the prevalent symptom of AA poisoning. (wikipedia.org)
  • Reports of this syndrome, now known as aristolochic acid nephropathy (AAN), called attention to the serious toxicities associated with the use of Aristolochia sp. (pnas.org)
  • AA was shown recently to be the causative agent of Balkan endemic nephropathy (EN) ( 6 , 7 ). (pnas.org)
  • Herbs and hazards: risk of Aristolochic acid nephropathy in Iran - Ardalan MR, Khodaie L, Nasri H, Jouyban A. Herbs are usually considered as inherently harmless products. (medworm.com)
  • The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. (medworm.com)
  • The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but with no change in glomeruli. (hindawi.com)
  • Thus, this renal disease is more appropriately called aristolochic acid nephropathy (AAN). (hindawi.com)
  • Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid found in Chinese herbs was first reported 20 years ago, aristolochic acid-induced nephropathy remains a worldwide health concern due to the lack of regulation on herbal medication and the easy availability of such medications online, according to a review published in the March 19 issue of the Annals of Internal Medicine . (medicalxpress.com)
  • HealthDay)-Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid (AA) found in Chinese herbs was first reported 20 years ago, AA-induced nephropathy remains a worldwide health concern due to the lack of regulation on herbal medication and the easy availability of such medications online, according to a review published in the March 19 issue of the Annals of Internal Medicine . (medicalxpress.com)
  • More than 100 cases of nephropathy over the last 10 years caused by the systemic and longer term application of Chinese snakeroot (Aristolochia fangchi) highlighted the risk of using preparations which contain aristolochic acids. (nih.gov)
  • Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). (mdpi.com)
  • Although aristolochic acid I (AAI), the major component of the natural plant extract AA, might directly cause interstitial nephropathy, enzymatic activation of AAI to reactive intermediates capable of binding to DNA is a necessary step leading to the formation of AA-DNA adducts and subsequently AA-induced malignant transformation. (mdpi.com)
  • 2007). Aristolochic acid and the etiology of endemic (Balkan) nephropathy. (springer.com)
  • Aristolochic acid nephropathy revisited: A place for innate and adaptive immunity? (thefreedictionary.com)
  • Introduction: Aristolochic acid I, a potent human nephrotoxic and carcinogenic compound produced by aristolochia plants, it is responsible for Balkan endemic nephropathy and is associated with urothelial carcinoma. (eurekaselect.com)
  • Patterns of interstitial inflammation during the evolution of renal injury in experimental aristolochic acid nephropathy. (ac.be)
  • The true incidence of aristolochic acid nephropathy (AAN) is thought to be underestimated because numerous ingredients known or suspected to contain aristolochic acid (AA) are used in traditional medicine in Korea. (kjim.org)
  • The first case of aristolochic acid nephropathy (AAN) was reported in Belgium [ 3 ], and several cases with irreversible renal toxicity after intake of AA-containing compounds have been reported. (kjim.org)
  • Aristolochic acids (AA), present in Aristolochia plants, are the toxin responsible for Chinese herbs nephropathy (CHN), a rapidly progressive tubulointerstitial nephritis (TIN). (elsevier.com)
  • Role of peritubular capillary loss and hypoxia in progressive tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy. (docphin.com)
  • Sun D, Feng J, Dai C, Sun L, Jin T, Ma J, Wang L. Role of peritubular capillary loss and hypoxia in progressive tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy. (docphin.com)
  • To investigate the effects of peritubular capillary (PTC) loss and hypoxia on the progression of tubulointerstitial fibrosis in a rat model of aristolochic acid nephropathy (AAN). (docphin.com)
  • In this study, we used a C3H/3e mouse model to investigate the relationship between urinary d-lactate and aristolochic acid nephropathy where the glomerular structure is not affected. (elsevier.com)
  • The nephropathy was induced using intravenous injections of aristolochic acid at a dosage of 10mg/kg per day for 5days and was characterized biochemically and histologically. (elsevier.com)
  • Of the many hypotheses on BEN, the Aristolochia hypothesis has recently gained ground substantiated by the investigations on aristolochic acid nephropathy (AAN). (oup.com)
  • 2] J.P. Cosyns: "Aristolochic acid and 'Chinese herbs nephropathy'-A review of the evidence to date", Drug Safety, Vol. 26, (2003) pp. 33-48. (edu.pl)
  • This study was designed to investigate the roles of aristolochic acid I (AA-I) and hypokalemia in acute aristolochic acid nephropathy (AAN). (kjim.org)
  • 1 ] were the first authors to observe, in an epidemiological study in Belgium, that Chinese herb nephropathy (CHN) can be induced by aristolochic acid (AA), one of the major constituents of Aristolochia fangchi [ 1 - 4 ]. (kjim.org)
  • Therefore, the designation of CHN was changed to the current term of aristolochic acid nephropathy (AAN). (kjim.org)
  • Aims: In this regard, we first confirmed the presence of PDGFRβ+ perivascular cells in a human case of end-stage aristolochic acid nephropathy (AAN) and thereafter we focused on the early fibrosis events of transforming growth factor β (TGFβ) inhibition in a rat model of AAN. (unamur.be)
  • Aim: Nephropathy associated with aristolochic acid (AA) has been documented by human and animal studies. (ncku.edu.tw)
  • Health food supplements containing aristolochic acids have been recently prohibited in several countries due to aristolochic acid nephropathy, which includes Chinese herb nephropathy and Balkan endemic nephropathy, all of which show renal impairment as a hallmark for the disease caused by the chronic ingestion of herbs containing these acids. (scielo.br)
  • Combined sodium bicarbonate and ascorbic acid could prevent contrast-induced nephropathy following catheterization in CKD patients. (greenmedinfo.com)
  • Ascorbic acid reduced the frequency and severity of renal injury in this murine model of contrast induced nephropathy. (greenmedinfo.com)
  • The poisoning with aristolochic acids was suggested when clinical and histopathological changes similar to those observed in the Balkan patients were reported in several cases of nephropathy in Belgian patients unintentionally exposed to aristolochic acids during a Chinese herbs diet. (omicsonline.org)
  • Since the 1950's, an unique kidney disease called Endemic (Balkan) Nephropathy (EN) is reported in Bosnia, Bulgaria, Croatia, Romania, and Serbia, countries located at South East part of Europe on the Balkan. (omicsonline.org)
  • First among these is aristolochic acid nephropathy. (urotoday.com)
  • 2014. miR-192 induces G2/M growth arrest in aristolochic acid nephropathy . (cardiff.ac.uk)
  • Aristolochic acid poisoning was first diagnosed at a clinic in Brussels, Belgium, when cases of nephritis leading to rapid kidney failure were seen in a group of women who had all taken the same weight-loss supplement, Aristolochia fangchi, which contained aristolochic acid. (wikipedia.org)
  • Aristolochic acid, a potent human carcinogen produced by Aristolochia plants, is associated with urothelial carcinoma of the upper urinary tract (UUC). (pnas.org)
  • Aristolochic acid (AA), a constituent of all Aristolochia plants, is a powerful nephrotoxin and human carcinogen associated with chronic kidney disease (CKD) and upper urinary tract urothelial carcinomas (UUC) ( 1 ). (pnas.org)
  • In EN, exposure to AA occurs via consumption of bread prepared from flour contaminated with seeds of Aristolochia clematitis ( 10 ). (pnas.org)
  • Scientists said the danger stems from chemicals called aristolochic acids, derived from the woody vines of Aristolochia plants. (medworm.com)
  • Aristolochia species used in the practice of traditional herbal medicine contains aristolochic acid (AA), an established human carcinogen contributing to urothelial carcinomas of the upper urinary tract. (nih.gov)
  • Aristolochic acids (AAs), the main compounds of species of Aristolochia [ 3 ], have been shown to cause tumor induction and renal toxicity in experimental and clinical studies [ 3 - 5 ]. (hindawi.com)
  • Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on bibliographic sources. (nih.gov)
  • Aristolochic acid (AA) is a component present in Chinese herbs (for example Asarum and Aristolochia ) from remedies for the treatment of arthritis pain, coughs and gastrointestinal symptoms ( 1 - 4 ). (spandidos-publications.com)
  • C 17 H 11 NO 7 , an acid derived from Aristolochia , a genus of flowering plants, and used as an herbal remedy. (thefreedictionary.com)
  • Larvae of the butterfly, Battus polydamas archidamas (Papilionidae: Troidini) feed exclusively on aristolochic acid (AAs)-containing Aristolochia species (Aristolochiaceae). (eje.cz)
  • FORDYCE J.A. 2000: A model without a mimic: aristolochic acids from the California pipevine swallowtail, Battus philenor hirsuta, and its host plant, Aristolochia californica. (eje.cz)
  • TR 1736) is the main component of plant extract Aristolochic acids, which are found in various herbal plants of genus Aristolochia and Asarum . (medchemexpress.com)
  • It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. (chemicalbook.com)
  • Aristolochic acid B is a carcinogenic compound found in Aristolochia and Radix that has commonly been used in traditional Chinese medicine. (thomassci.com)
  • That exposure to aristolochic acid (AA) of individuals living in endemic areas through consumption of bread made with flour contaminated with seeds of Aristolochia clematitis is responsible for BEN is an old hypothesis, but one which is fully. (oup.com)
  • Aristolochia macrophylla contains the natural substance aristolochic acid, which is found in all plants of the family Aristolochiaceae. (wikipedia.org)
  • A phytochemical study of Aristolochia melastoma Manso has led to the isolation and identification of 20 known compounds, including aristolochic acids, sodium aristolochates, lignan, flavonoids, and nitro phenylethyl derivatives. (scielo.br)
  • 4,5 Phytochemical and pharmaceutical studies on the chemical constituents of the Aristolochia spp have mainly focused on aristolochic acids (AAs), which have a 3,4-methylenedioxy-10-nitrophenanthrenic-1-acid carbon skeleton. (scielo.br)
  • It has been demonstrated in a number of Aristolochia -feeders that caterpillars are able to sequester aristolochic acids, causing both the larval and adult stages to be unpalatable to predators (eg. (tolweb.org)
  • Despite its presence in ancient medicine, Aristolochia is known to contain the lethal toxin aristolochic acid . (wikipedia.org)
  • The plant contains aristolochic acid, this has received rather mixed reports on its toxicity. (pfaf.org)
  • The root contains aristolochic acid. (pfaf.org)
  • The plant contains aristolochic acid, a carcinogenic compound. (newworldencyclopedia.org)
  • It also contains aristolochic acid, which has antitumor activity[222]. (pfaf.org)
  • Aristolochic acids (English: /əˌrɪstəˈloʊkɪk/) are a family of carcinogenic, mutagenic, and nephrotoxic phytochemicals commonly found in the flowering plant family Aristolochiaceae (birthworts). (wikipedia.org)
  • Adeleh Yadeghari, Mohammadreza Ardalan, Mir Ali Farajzadeh and Abolghasem Jouyban*, "A Microextraction Liquid-Chromatographic Determination of Aristolochic Acid I in Urine, Flour, and Aristolochiaceae Fruit", Current Pharmaceutical Analysis (2017) 13: 345. (eurekaselect.com)
  • Uses Aristolochic acids occur in Aristolochiaceae and in butterflies feeding on these plants. (chemicalbook.com)
  • Plants of the family Aristolochiaceae contain aristolochic acids in their leaves and stems. (wikipedia.org)
  • Patients with aristolochic acid toxicity are also prone to developing malignancies of the urinary tract (e.g. bladder cancer). (blogspot.com)
  • BALACHANDRAN P., WEI F., LIN R.C., KHAN I.A. & PASCO D.S. 2005: Structure activity relationships of aristolochic acids analogues: toxicity in cultured renal epithelial cells. (eje.cz)
  • However, in 1981, a three-month toxicity study in rats revealed the carcinogenic potential of aristolochic acid and preparations containing this substance have since been withdrawn in several countries. (chemicalbook.com)
  • Using metabonomics, an emerging dynamic technique that allows an effective mapping of alterations in endogenous metabolites levels in biofluids and tissues, we evaluated early signs of renal toxicity from extra urine samples collected in a rat model of intoxication with aristolochic acids. (omicsonline.org)
  • It is also used to recover lead from used lead-acid batteries, and as an oral chelation agent to clean up heavy metal toxicity. (healthy-eating-politics.com)
  • However, there is concern over their use as aristolochic acid is b th carcinogenic and nephrotoxic. (chemicalbook.com)
  • Some plants and herbs may contain aristolochic acid or nephrotoxic phytochemicals. (kidney.org)
  • The predictive value of different urinary and transcriptional biomarkers was evaluated in a proof-of-principle toxicology study in rats using aristolochic acid (AA), a known nephrotoxic agent. (mesoscale.com)
  • A study reported in the Science Translational Medicine journal in October 2017 reported high incidences of liver cancer in Asia, particularly Taiwan, which bore the "well-defined mutational signature" of aristolochic acids. (wikipedia.org)
  • Jelaković B, Castells X, Tomić K, Ardin M, Karanović S, Zavadil J. Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid. (iarc.fr)
  • Glacial (highly purified) acetic acid contains at least 99.5% acetic acid by weight. (thefreedictionary.com)
  • The samples were analyzed on an Alltima C18 column eluted with methanol - water - acetic acid (68321.5) as the mobile phase. (bvsalud.org)
  • 16. The method of claim 15 wherein said additive is selected from trifluoroacetic acid, citric acid, acetic acid, trimethyl amine, and trimethyl ammonium hydroxide. (freepatentsonline.com)
  • We conclude that exposure to aristolochic acid contributes significantly to the incidence of UUC in Taiwan, a finding with significant implications for global public health. (pnas.org)
  • McGill University) A new study on a large cohort of kidney cancer patients in Europe sheds light on the genetic architecture of the disease -- and reveals an apparent link between exposure to aristolochic acid and incidence of kidney cancer, particularly in Romania. (medworm.com)
  • Association between cancer incidence and exposure to aristolochic acid -- an ingredient in some herbal remedies -- has implications for public health, particularly in Romania. (medworm.com)
  • Potential Exposure Aristolochic acids are alkaloids used primarily as a chemical intermediate for pharmaceuticals, lab chemicals, herbal extract, drug. (chemicalbook.com)
  • I was dumbstruck to find the evidence of exposure to aristolochic acid in 78 per cent of cases," says Rozen. (newscientist.com)
  • It reflects the need to protect public from exposure to herbal medicinal products containing aristolochic acids. (europa.eu)
  • A HPLC method for limit detection of aristolochic acid A in the Chinese herbs containing aristolochic acid or suspected-containing aristolochic acid and their preparations was established. (bvsalud.org)
  • Among 15 batches samples of Chinese medicaments, only one sample was found to contain aristolochic acid A. The present investigation shows that the method is sensitive and repeatable and it could be used for the limit detection of aristolochic acid A in the Chinese herbal medicines containing trace amount of aristolochic acid A or suspected-containing aristolochic acid A and their preparations. (bvsalud.org)
  • 3] J.R. Ioset, G.E. Raoelison and K. Hostettmann: "Detection of aristolochic acid in Chinese phytomedicines and dietary supplements used as slimming regimens", Food Chem. (edu.pl)
  • 6] J.R. Ioset, G.E. Raoelison and K. Hostettmann: "An LC/DAD-UV/MS method for the rapid detection of aristolochic acid in plant preparations", Planta Med. (edu.pl)
  • The herbal drug known as aristolochic acid contains a mixture of numerous structurally related nitrophenanthrene carboxylic acids generally consisting of two major compounds: aristolochic acid I (AA-I) and aristolochic acid II (AA-II). (wikipedia.org)
  • Safety concerns of herbal products and traditional Chinese herbal medicines: dehydropyrrolizidine alkaloids and aristolochic acid - Stegelmeier BL, Brown AW, Welch KD. (medworm.com)
  • Singapore, 19 October 2017 - Scientists from Singapore and Taiwan have revealed a decisive link between Aristolochic Acids (AA), a natural product of some plants used in herbal remedies, and liver cancers. (duke-nus.edu.sg)
  • The aristolochic acid is a plant compound contained in herbal remedies used for thousands of years to treat a variety of ailments like arthritis, gout and inflammation. (thefreedictionary.com)
  • Washington, Dec 22 (ANI): The consumption of popular Chinese herbal products containing carcinogen aristolochic acid is linked to an increased risk of urinary tract cancer, a new study has found. (thefreedictionary.com)
  • ARLT V.M., STIBOROVA M. & SCHMEISER H.H. 2002: Aristolochic acid as a probable human cancer hazard in herbal remedies: a review. (eje.cz)
  • Aristolochic acid is found in the Birthwort plant and was long used in Chinese herbal medicine as well as being cultivated as an ornamental plant. (innerself.com)
  • However, aristolochic acid may not be the only cause of the cancer-linked mutation, so it's unclear how many of these cases were caused by herbal medicine. (newscientist.com)
  • Some herbal remedies that contain aristolochic acid include Mu-Tong and Fangchi. (catie.ca)
  • A ristolochic acids (AAs) are powerful nephrotoxin and human carcinogen associated with chronic kidney disease and upper urinary tract urothelial carcinomas. (omicsonline.org)
  • Here, we report a novel approach to investigate the premalignant events triggered by human carcinogen aristolochic acid I (AAI) in the liver-like tissue derived from mouse embryonic stem cells. (oncotarget.com)
  • Aristolochic acid I (AAI), a nitrophenanthrene derivative, is the main compound of the naturally occurring carcinogen aristolochic acid. (springer.com)
  • After a single intravenous administration of 0.5 mg/kg aristolochic acid sodium (AANa), rabbits exhibited mild to moderate nephrotoxicity on the 7th day. (hindawi.com)
  • 2017). Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. (springer.com)
  • The acid is a known carcinogen, and its use has been associated with and may cause end-stage renal disease and cancers of the urinary tract that may occur many years after usage has stopped. (thefreedictionary.com)
  • Aristolochic acid is a very dangerous compound in that this acid is a potent mutagen and carcinogen that can cause urological cancers as well as permanent kidney failure. (wikipedia.org)
  • This indicates strongly that aristolochic acid was one of the causes of these cancers. (newscientist.com)
  • Aristolochic acid (AA) related mutations cause liver cancers, urinary tract cancers and kidney failure. (medindia.net)
  • 7] T.Y. Lee, M.L. Wu, J.F. Deng and D.F. Hwang: "High-performance liquid chromatographic determination for aristolochic acid in medicinal plants and slimming products", J. Chromatogr. (edu.pl)
  • Aristolochic acid can also be used in the treatment of acute and serious infections such as TB, hepatitis, liver cirrhosis and infantile pneumonia[176]. (pfaf.org)
  • Aristolochic acid A (150, 200 μM, 24 hours) inhibits the cell viabilities of kidney cells HEK293 and HK-2 [1] . (medchemexpress.com)
  • Aristolochic acid A (100, 200 μM, 24 hours) causes a concentration-dependent decrease in bladder cancer-associated protein ( BLCAP ) mRNA levels in kidney cells (HEK 293 and HK-2) , and bladder cancer cell line (HT-1376) [1] . (medchemexpress.com)
  • Health Canada is advising consumers not to use products containing Aristolochic Acid, a naturally occurring toxin that can cause cancer, mutations in human cells, and end-stage kidney failure. (news-medical.net)
  • An exploratory evaluation of the utility of transcriptional and urinary kidney injury biomarkers for the prediction of aristolochic acid-induced renal injury in male rats. (mesoscale.com)
  • Naturally occurring aristolochic acid analogues and their toxicities. (thefreedictionary.com)
  • 5] J.H. Jon, S.S. Chen and T.S. Wu: "Facile reversed-phase HPLC resolution and quantitative determination of aristolochic acid and aristolactam analogues in traditional Chinese medicine", J. Liq. (edu.pl)
  • A simple and rapid capillary zone electrophoresis (CZE) method for the determination of aristolochic acid (AA) in dietary supplements and selected herbs is described. (infona.pl)
  • 8] E.S. Ong and S.O. Woo: "Determination of aristolochic acids in medicinal plants (Chinese) prepared medicine using capillary zone electrophoresis", Electrophoresis, Vol. 22, (2001) pp. 2236-2241. (edu.pl)
  • The biosynthesis of these compounds has been of considerable interest due in large part to the inclusion of both an aryl carboxylic acid and an aryl nitro functionality (uncommon in natural products) within their structures, which suggested an apparent biogenetic relationship to the well-known aporphine alkaloids. (wikipedia.org)
  • Surprisingly, most of the mutants avoided all but one of the bitter compounds - aristolochic acid , a naturally occurring chemical produced by plants to prevent themselves from being eaten by insects. (thefreedictionary.com)
  • Aristolochic acid (AA)-containing compounds have been used as antiviral, antibacterial, anti-inflammatory, anti-neoplastic, and slimming agents [ 1 , 2 ] for a long time. (kjim.org)
  • Aristolochic Acid in the Etiology of Renal Cell Carcinoma. (nih.gov)
  • Aristolochic acid is an herb used in many varieties of Chinese herbs and health supplements. (blogspot.com)
  • Herbs containing aristolochic acid that have been linked to epidemics of CKD. (kidney.org)
  • Chinese herbs that contain aristolochic acid. (catie.ca)
  • 9] H.A. Priestap, S.L. Iglesias, M.F. Desimone and L.E. Diaz: "Determination of aristolochic acids by capillary electrophoresis", J. Capillary Electrop. (edu.pl)
  • C 10 H 18 N 4 O 6 , a compound intermediate in the synthesis of arginine, formed from citrulline and aspartic acid. (thefreedictionary.com)
  • This species of plant has received considerable attention in the past few decades for the discovery of a potent compound called aristolochic acid, which has been the focus of debate due its harmful side effects. (wikipedia.org)
  • Even though aristolochic acid has been found to expedite and arouse the activity of white blood cells, speed the healing of wounds, and possibly be used in concurrence with chemotherapy and radiation therapy,[medical citation needed] this compound is highly carcinogenic and is very deleterious to renal health. (wikipedia.org)
  • In 2013, researchers found that a compound in the plants, known as aristolochic acid, seems to cause gene mutations by targeting the base adenine , a component of DNA's genetic code. (newscientist.com)
  • Wild ginger ( Asarum canadense ) was included on a list issued by the FDA as an herb containing aristolochic acid, a compound that has been banned from the herb trade in the year 2000. (itmonline.org)
  • The main process of removing aristolochic acid is by eliminating potential sources of it (alternatively, every batch of material that is of concern can be tested for the compound). (itmonline.org)
  • Consumption of aristolochic acid can also induce uterine bleeding. (wikipedia.org)
  • When a member of Rozen's team spotted the same type of mutation occurring in liver cancer , the group wondered if plants that contain aristolochic acid might increase a person's chances of developing the disease. (newscientist.com)
  • A systematic assessment of the content of aristolochic acids in the most widely used species is needed to evaluate whether their uses pose a potential health risk. (nih.gov)
  • Using this method, we discovered potential histopathological diagnosis biomarkers (including lipids, amino acids, choline, peptides and carnitine) from 52 postoperative lung cancer tissue samples and then subsequently used these biomarkers to generate images for rapid and label-free histopathological diagnosis. (nature.com)
  • C 18 H 30 O 2 , an omega-3 fatty acid derived from plants, esp. (thefreedictionary.com)
  • C 20 H 32 O 2 , an omega-6 fatty acid formed by the action of enzymes on phospholipids in cell membranes. (thefreedictionary.com)
  • in diabetic ketoacidosis, when the conversion of fatty acids to ketones increases. (tabers.com)
  • Poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) [P(3HB-co-3HHx)], a flexible and practical kind of polyhydroxyalkanoates, is generally produced from plant oils and fatty acids by several wild and recombinant bacteria. (biomedsearch.com)
  • C 4 H 7 NO 4 , a nonessential amino acid that is a product of pancreatic digestion. (thefreedictionary.com)
  • C 4 H 7 NO 4 , a nonessential amino acid. (tabers.com)
  • An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. (biomedsearch.com)
  • System L is a major transport system for cellular uptake of neutral amino acids. (nii.ac.jp)
  • Among system L transporters, L-type amino acid transporter 1 (LAT1) is responsible for the nutrient uptake in cancer cells, whereas L-type amino acid transporter 2 (LAT2) is a transporter for non-cancer cells. (nii.ac.jp)
  • In the early first century, in Roman texts, aristolochic acids are first mentioned as a component of frequently ingested medicines to treat things such as asthma, hiccups, spasms, pains, and expulsion of afterbirth. (wikipedia.org)
  • DI-fusion Holdings: Aristolochic acid induces proximal tubule apoptosis. (ac.be)
  • Aristolochic acid induces proximal tubule apoptosis and epithelial to mesenchymal transformation. (ac.be)
  • The AlkB family of Fe(II)/α-ketoglutarate-dependent dioxygenases: repairing nucleic acid alkylation damage and beyond. (springer.com)
  • Nucleic Acids Res 40, 2494-2505. (springer.com)
  • Enhancing Nucleic Acid Delivery, Insights from the Cationic Phospholipid Carriers. (biomedsearch.com)
  • The development of nucleic acid-based drugs has attracted considerable interest in the past two decades as a new category of biologics. (biomedsearch.com)
  • Aristolochic acid (AA) I is the most abundant one. (wikipedia.org)
  • Aristolochic acid I (AA-I) is the most abundant type of the aristolochic acids. (omicsonline.org)
  • To investigate the effects of AA on the renal function of rabbits, the current study was performed to assess the PKs of p -aminohippuric acid (PAH) and inulin in 0.5 mg/kg AANa-treated rabbits. (hindawi.com)
  • A mixture of 20 mM-morpholinethanesulphonic acid+10 mM-BisTrisPropane+0.2% hydroxyethylcelullose in 10% methanol serves as a background electrolyte. (infona.pl)
  • C 4 H 8 O 3 , any of the acids present in the urine, esp. (tabers.com)
  • Ingestion of aristolochic acid (AA) is associated with development of urothelial tumors linked with aristolochic acid nephropa. (nel.edu)