Aristolochic Acids: Nitro-phenanthrenes occurring in ARISTOLOCHIACEAE and other plants. They derive from stephanine (APORPHINES) by oxidative ring cleavage. The nitro group is a reactive alkylator (ALKYLATING AGENTS) that binds to biological macromolecules. Ingestion by humans is associated with nephropathy (NEPHRITIS). There is no relationship to the similar named aristolochene (SESQUITERPENES).Aristolochia: A plant genus of the family ARISTOLOCHIACEAE. Species of this genus have been used in traditional medicine but they contain aristolochic acid which is associated with nephropathy. These are sometimes called 'snakeroot' but that name is also used with a number of other plants such as POLYGALA; SANICULA; ASARUM; ARISTOLOCHIA; AGERATINA; and others.Balkan Nephropathy: A form of chronic interstitial nephritis that is endemic to limited areas of BULGARIA, the former YUGOSLAVIA, and ROMANIA. It is characterized by a progressive shrinking of the KIDNEYS that is often associated with uroepithelial tumors.PhenanthrenesDNA Adducts: The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.Urologic Neoplasms: Tumors or cancer of the URINARY TRACT in either the male or the female.Urethral Neoplasms: Cancer or tumors of the URETHRA. Benign epithelial tumors of the urethra usually consist of squamous and transitional cells. Primary urethral carcinomas are rare and typically of squamous cells. Urethral carcinoma is the only urological malignancy that is more common in females than in males.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.Herbal Medicine: The study of medicines derived from botanical sources.Ochratoxins: Isocoumarins found in ASPERGILLUS OCHRACEUS and other FUNGI. Ochratoxin contaminated FOOD has been responsible for cases of FOODBORNE DISEASES.Phenindione: An indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)Ethnopharmacology: The study of the actions and properties of medicinal agents, often derived from PLANTS, indigenous to populations or ETHNIC GROUPS.Carcinogens: Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included.Chemistry Techniques, Analytical: Methodologies used for the isolation, identification, detection, and quantitation of chemical substances.Noxae: Agents capable of exerting a harmful effect on the body.Manduca: A genus of sphinx or hawk moths of the family Sphingidae. These insects are used in molecular biology studies during all stages of their life cycle.Serbia: A republic located south of HUNGARY, west of ROMANIA and BULGARIA, and part of the former YUGOSLAVIA. The capital is Belgrade.Mutagens: Chemical agents that increase the rate of genetic mutation by interfering with the function of nucleic acids. A clastogen is a specific mutagen that causes breaks in chromosomes.Benzyl Alcohols: Alcohols derived from the aryl radical (C6H5CH2-) and defined by C6H5CHOH. The concept includes derivatives with any substituents on the benzene ring.Cytochrome P-450 CYP1A2: A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Biotransformation: The chemical alteration of an exogenous substance by or in a biological system. The alteration may inactivate the compound or it may result in the production of an active metabolite of an inactive parent compound. The alterations may be divided into METABOLIC DETOXICATION, PHASE I and METABOLIC DETOXICATION, PHASE II.Phospholipases A: Phospholipases that hydrolyze one of the acyl groups of phosphoglycerides or glycerophosphatidates.Croatia: Created 7 April 1992 as a result of the division of Yugoslavia.Kidney Diseases: Pathological processes of the KIDNEY or its component tissues.Carcinoma, Transitional Cell: A malignant neoplasm derived from TRANSITIONAL EPITHELIAL CELLS, occurring chiefly in the URINARY BLADDER; URETERS; or RENAL PELVIS.Lac Repressors: Bacterial repressor proteins that bind to the LAC OPERON and thereby prevent the synthesis of proteins involved in catabolism of LACTOSE. When lactose levels are high lac repressors undergo an allosteric change that causes their release from the DNA and the resumption of lac operon transcription.Urinary Bladder Neoplasms: Tumors or cancer of the URINARY BLADDER.Scavenger Receptors, Class F: A group of structurally related scavenger receptors expressed predominately by ENDOTHELIAL CELLS. They-contain repeats of EPIDERMAL GROWTH FACTOR-like cysteine-rich motifs in their extracellular domains.Carcinoma, Renal Cell: A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are several subtypes including the clear cells, the papillary, the chromophobe, the collecting duct, the spindle cells (sarcomatoid), or mixed cell-type carcinoma.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Kidney Neoplasms: Tumors or cancers of the KIDNEY.World Health: The concept pertaining to the health status of inhabitants of the world.Ureteral Neoplasms: Cancer or tumors of the URETER which may cause obstruction leading to hydroureter, HYDRONEPHROSIS, and PYELONEPHRITIS. HEMATURIA is a common symptom.Ureter: One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.Kidney Pelvis: The flattened, funnel-shaped expansion connecting the URETER to the KIDNEY CALICES.Urothelium: The epithelial lining of the URINARY TRACT.Entomology: A discipline or occupation concerned with the study of INSECTS, including the biology and the control of insects.Aristolochiaceae: A plant family of the order Aristolochiales subclass Magnoliidae class Magnoliopsida. They are mostly tropical woody vines and a few temperate-zone species. The flowers are 3-parted; some species lack petals while others are large and foul smelling.Butterflies: Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.Oocytes: Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).Zona Pellucida: A tough transparent membrane surrounding the OVUM. It is penetrated by the sperm during FERTILIZATION.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Dictionaries, ChemicalTerminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Acupuncture Therapy: Treatment of disease by inserting needles along specific pathways or meridians. The placement varies with the disease being treated. It is sometimes used in conjunction with heat, moxibustion, acupressure, or electric stimulation.Pimpinella: A plant genus in the family APIACEAE (Umbelliferae) that is used in SPICES and is a source of anethole.Acupuncture: The occupational discipline of the traditional Chinese methods of ACUPUNCTURE THERAPY for treating disease by inserting needles along specific pathways or meridians.Pesticide Synergists: Chemicals that, while not possessing inherent pesticidal activity, nonetheless promote or enhance the effectiveness of other pesticides when combined.Naturopathy: A drugless system of therapy, making use of physical forces such as air, light, water, heat, massage. Treatments are often diet- and nutrition-oriented with attention given to the patient's personal history and lifestyle. (From Cassileth, Alternative Medicine Handbook, 1998, p329)Chromium: A trace element that plays a role in glucose metabolism. It has the atomic symbol Cr, atomic number 24, and atomic weight 52. According to the Fourth Annual Report on Carcinogens (NTP85-002,1985), chromium and some of its compounds have been listed as known carcinogens.Piperonyl Butoxide: An insecticide synergist, especially for pyrethroids and ROTENONE.

Interleukin-1 stimulates Jun N-terminal/stress-activated protein kinase by an arachidonate-dependent mechanism in mesangial cells. (1/122)

BACKGROUND: We have studied interleukin-1 (IL-1)-stimulated signals and gene expression in mesangial cells (MCs) to identify molecular mechanisms of MC activation, a process characteristic of glomerular inflammation. The JNK1 pathway has been implicated in cell fate decisions, and IL-1 stimulates the Jun N-terminal/stress-activated protein kinases (JNK1/SAPK). However, early postreceptor mechanisms by which IL-1 activates these enzymes remain unclear. Free arachidonic acid (AA) activates several protein kinases, and because IL-1 rapidly stimulates phospholipase A2 (PLA2) activity release AA, IL-1-induced activation of JNK1/SAPK may be mediated by AA release. METHODS: MCs were grown from collagenase-treated glomeruli, and JNK/SAPK activity in MC lysates was determined using an immunocomplex kinase assay. RESULT: Treatment of MCs with IL-1 alpha induced a time-dependent increase in JNK1/SAPK kinase activity, assessed by phosphorylation of the activating transcription factor-2 (ATF-2). Using similar incubation conditions, IL-1 also increased [3H]AA release from MCs. Pretreatment of MCs with aristolochic acid, a PLA2 inhibitor, concordantly reduced IL-1-regulated [3H]AA release and JNK1/SAPK activity, suggesting that cytosolic AA in part mediates IL-1-induced JNK1/SAPK activation. Addition of AA stimulated JNK1/SAPK activity in a time- and concentration-dependent manner. This effect was AA specific, as only AA and its precursor linoleic acid stimulated JNK1/SAPK activity. Other fatty acids failed to activate JNK1/SAPK. Pretreatment of MCs with specific inhibitors of AA oxidation by cyclooxygenase, lipoxygenase, and cytochrome P-450 epoxygenase had no effect on either IL-1- or AA-induced JNK1/SAPK activation. Furthermore, stimulation of MCs with the exogenous cyclooxygenase-, lipoxygenase-, phosphodiesterase-, and epoxygenase-derived arachidonate metabolites, in contrast to AA itself, did not activate JNK1/SAPK. CONCLUSION: We conclude that IL-1-stimulated AA release, in part, mediates stimulation of JNK1/SAPK activity and that AA activates JNK1/SAPK by a mechanism that does not require enzymatic oxygenation. JNK1 signaling pathway components may provide molecular switches that mediate structural rearrangements and biochemical processes characteristic of MC activation and could provide a novel target(s) for therapeutic intervention.  (+info)

Pentoxifylline-stimulated capacitation and acrosome reaction in hamster spermatozoa: involvement of intracellular signalling molecules. (2/122)

We investigated the role of cAMP/cGMP, protein kinases and intracellular calcium ( [Ca2+]i) in pentoxifylline-stimulated hamster sperm capacitation and the acrosome reaction (AR) in vitro. Treatment with pentoxifylline (0.45 mM) initially increased sperm cAMP values 2.8-fold, compared with untreated controls (396 +/- 9.2 versus 141 +/- 6.0 fmoles/10(6) spermatozoa; mean +/- SEM, n = 6) after 15 min, although by 3 h, cAMP values were similar (503-531 fmoles/10(6) spermatozoa). cGMP values ( approximately 27 fmoles/10(6) spermatozoa) were the same in treated and control spermatozoa. Both sperm capacitation and the AR, determined from the absence of an acrosomal cap, were stimulated by pentoxifylline; these were almost completely inhibited by a Cl-/ HCO3- antiporter inhibitor (4,4-diisothiocyanato-stilbene-2,2 disulphonic acid; 1 mM) defined from the degree of sperm motility and by a protein kinase A inhibitor (H89; 10 microM). A protein kinase C inhibitor (staurosporine, 1 nM) did not affect pentoxifylline-stimulated capacitation but inhibited the AR by 50%. A protein tyrosine kinase inhibitor (tyrphostin A-47, 0.1 mM) had no effect on either pentoxifylline-stimulated capacitation or AR. A phospholipase A2 inhibitor (aristolochic acid, 0.4 mM) markedly inhibited the pentoxifylline-stimulated AR but not capacitation. When intracellular sperm calcium [Ca2+/-]i was measured using fura-2-AM, there was an early rise (271 nM at 0.5 h) in pentoxifylline-treated spermatozoa; this appeared to be due to intracellular mobilization rather than to uptake. In the absence of extracellular Ca2+, sperm motility was maintained in the presence of pentoxifylline, but capacitation did not occur; spermatozoa exhibited a low level of hyperactivated motility and had a poor rate of AR (20.5 +/- 2.3%). These results suggest that: (i) the pentoxifylline-stimulated early onset of sperm capacitation may be mediated by an early rise in cAMP and [Ca2+/-]i and involves protein kinase A activity; and (ii) pentoxifylline-stimulated AR may require phospholipase A2 and protein kinase C activity.  (+info)

Formation of reactive oxygen species by the contracting diaphragm is PLA(2) dependent. (3/122)

Recent work indicates that respiratory muscles generate superoxide radicals during contraction (M. B. Reid, K. E. Haack, K. M. Francik, P. A. Volberg, L. Kabzik, and M. S. West. J. Appl. Physiol. 73: 1797-1804, 1992). The intracellular pathways involved in this process are, however, unknown. The purpose of the present study was to test the hypothesis that contraction-related formation of reactive oxygen species (ROS) by skeletal muscle is linked to activation of the 14-kDa isoform of phospholipase A(2) (PLA(2)). Studies were performed by using an in vitro hemidiaphragm preparation submerged in an organ bath, and formation of ROS in muscles was assessed by using a recently described fluorescent indicator technique. We examined ROS formation in resting and contracting muscle preparations and then determined whether contraction-related ROS generation could be altered by administration of various PLA(2) inhibitors: manoalide and aristolochic acid, both inhibitors of 14-kDa PLA(2); arachidonyltrifluoromethyl ketone (AACOCF(3)), an inhibitor of 85-kDa PLA(2); and haloenol lactone suicide substrate (HELSS), an inhibitor of calcium-independent PLA(2). We found 1) little ROS formation [2.0 +/- 0.8 (SE) ng/mg] in noncontracting control diaphragms, 2) a high level of ROS (20.0 +/- 2.0 ng/mg) in electrically stimulated contracting diaphragms (trains of 20-Hz stimuli for 10 min, train rate 0.25 s(-1)), 3) near-complete suppression of ROS generation in manoalide (3.0 +/- 0.5 ng/mg, P < 0. 001)- and aristolochic acid-treated contracting diaphragms (4.0 +/- 1.0 ng/mg, P < 0.001), and 4) no effect of AACOCF(3) or HELSS on ROS formation in contracting diaphragm. During in vitro studies examining fluorescent measurement of ROS formation in response to a hypoxanthine/xanthine oxidase superoxide-generating solution, manoalide, aristolochic acid, AACOCF(3), and HELSS had no effect on signal intensity. These data indicate that ROS formation by contracting diaphragm muscle can be suppressed by the administration of inhibitors of the 14-kDa isoform of PLA(2) and suggest that this enzyme plays a critical role in modulating ROS formation during muscle contraction.  (+info)

W-7 induces [Ca(2+)](i) increases in Madin-Darby canine kidney (MDCK) cells. (4/122)

The effect of W-7 [N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide hydrochloride] on Ca(2+) signaling in Madin-Darby canine kidney cells was investigated. W-7 (0.1-1 mM) induced a [Ca(2+)](i) increase, which comprised an initial increase and a plateau. Ca(2+) removal inhibited the Ca(2+) signals by 80%, suggesting that W-7 activated external Ca(2+) influx and internal Ca(2+) release. Pretreatment with the mitochondrial uncoupler carbonylcyanide m-chlorophenylhydrazone (2 microM) and the endoplasmic reticulum Ca(2+) pump inhibitor thapsigargin (1 microM) abolished the internal Ca(2+) release induced by 0.5 mM W-7; conversely, pretreatment with W-7 prevented thapsigargin and carbonylcyanide m-chlorophenylhydrazone from releasing internal Ca(2+). W-7 (0.2 mM) induced Mn(2+) quench of fura-2 fluorescence, which was inhibited by La(3+) (0.1 mM) by 80%. La(3+) (0.1 mM) partly inhibited 0.2 mM W-7-induced [Ca(2+)](i) increase. Addition of 5 mM Ca(2+) induced a significant [Ca(2+)](i) increase after pretreating with 0.2 to 1 mM W-7 in Ca(2+)-free medium for 5 min, suggesting that W-7 induced capacitative Ca(2+) entry. W-7 (0.5 mM) potentiated the capacitative Ca(2+) entry induced by 1 microM thapsigargin by 15%. Pretreatment with aristolochic acid (40 microM) to inhibit phospholipase A(2) reduced 0.5 mM W-7-induced internal Ca(2+) release and external Ca(2+) influx by 25 and 80%, respectively. Inhibition of phospholipase C with U73122 (2 microM) or inhibition of phospholipase D with propranolol (0.1 mM) had no effect on the internal Ca(2+) release induced by 0.5 mM W-7. It remains unclear whether W-7 induced [Ca(2+)](i) increases via inhibition of calmodulin. Three other calmodulin inhibitors (phenoxybenzamine, trifluoperazine, and fluphenazine-N-chloroethane) did not alter resting [Ca(2+)](i).  (+info)

Using polymerase arrest to detect DNA binding specificity of aristolochic acid in the mouse H-ras gene. (5/122)

The distribution of DNA adducts formed by the two main components, aristolochic acid I (AAI) and aristolochic acid II (AAII), of the carcinogenic plant extract aristolochic acid (AA) was examined in a plasmid containing exon 2 of the mouse c-H-ras gene by a polymerase arrest assay. AAI and AAII were reacted with plasmid DNA by reductive activation and the resulting DNA adducts were identified as the previously characterized adenine adducts (dA-AAI and dA-AAII) and guanine adducts (dG-AAI and dG-AAII) by the (32)P-post-labeling method. In addition, a structurally unknown adduct was detected in AAII-modified DNA and shown to be derived from reaction with cytosine (dC-AAII). Sites at which DNA polymerase progress along the template was blocked were assumed to be at the nucleotide 3' to the adduct. Polymerase arrest spectra showed a preference for reaction with purine bases in the mouse H-ras gene for both activated compounds, consistent with previous results that purine adducts are the principal reaction products of AAI and AAII with DNA. Despite the structural similarities among AAI-DNA and AAII-DNA adducts, however, the polymerase arrest spectra produced by the AAs were different. According to the (32)P-post-labeling analyses reductively activated AAI showed a strong preference for reacting with guanine residues in plasmid DNA, however, the polymerase arrest assay revealed arrest sites preferentially at adenine residues. In contrast, activated AAII reacted preferentially with adenine rather than guanine residues and to a lesser extent with cytosine but DNA polymerase was arrested at guanine as well as adenine and cytosine residues with nearly the same average relative intensity. Thus, the polymerase arrest spectra obtained with the AA-adducted ras sequence do not reflect the DNA adduct distribution in plasmid DNA as determined by (32)P-post-labeling. Arrest sites of DNA polymerase associated with cytosine residues confirmed the presence of a cytosine adduct in DNA modified by AAII. For both compounds adduct distribution was not random; instead, regions with adduct hot spots and cold spots were observed. Results from nearest neighbor binding analysis indicated that flanking pyrimidines displayed the greatest effect on polymerase arrest and therefore on DNA binding by AA.  (+info)

Stimulation of Ca(2+)-dependent exocytosis of the sperm acrosome by cAMP acting downstream of phospholipase A2. (6/122)

Spermatozoa undergo exocytosis in response to agonists that induce Ca2+ influx and, in turn, activation of phosphoinositidase C, phospholipase C, phospholipase A2, and cAMP formation. Since the role of cAMP downstream of Ca2+ influx is unknown, this study investigated whether cAMP modulates phospholipase C or phospholipase A2 using a ram sperm model stimulated with A23187 and Ca2+. Exposure to dibutyryl-cAMP, phosphodiesterase inhibitors or forskolin resulted in enhancement of exocytosis. However, the effect was not due to stimulation of phospholipase C or phospholipase A2: in spermatozoa prelabelled with [3H]palmitic acid or [14C]arachidonic acid, these reagents did not enhance [3H]diacylglycerol formation or [14C]arachidonic acid release. Spermatozoa were treated with the phospholipase A2 inhibitor aristolochic acid, and dibutyryl-cAMP to test whether cAMP acts downstream of phospholipase A2. Under these conditions, exocytosis did not occur in response to A23187 and Ca2+. However, inclusion of dibutyryl-cAMP and the phospholipase A2 metabolite lysophosphatidylcholine did result in exocytosis (at an extent similar to that seen when cells were treated with A23187/Ca2+ and without the inhibitor). Inclusion of lysophosphatidylcholine alone, without dibutyryl-cAMP, enhanced exocytosis to a lesser extent, demonstrating that cAMP requires a phospholipase A2 metabolite to stimulate the final stages of exocytosis. These results indicate that cAMP may act downstream of phospholipase A2, exerting a regulatory role in the exocytosis triggered by physiological agonists.  (+info)

Effects of inhibitors of arachidonic acid turnover on the production of prostaglandins by the guinea-pig uterus. (7/122)

The supply of free arachidonic acid from phospholipids is generally regarded as the rate-limiting step for prostaglandin (PG) synthesis by tissues. Two enzymes involved in arachidonic acid uptake into, and release from, phospholipids are acyl-CoA:lysophospholipid acyltransferase (ACLAT) and phospholipase A2 (PLA2), respectively. PGF2 alpha produced by the endometrium induces luteolysis in several species including guinea-pigs. Thimerosal, an inhibitor of ACLAT, and aristolochic acid, an inhibitor of PLA2, both reduced, in a concentration-dependent manner, the output of PGF2 alpha from guinea-pig endometrium cultured for 24 h on days 7 and 15 of the oestrous cycle. This study showed that the continual production of PGF 2 alpha by guinea-pig endometrium is not only dependent upon the activity of PLA2 for releasing free arachidonic acid for PGF2 alpha synthesis, but also on the incorporation of arachidonic acid into the phospholipid pool by the activity of ACLAT. The inhibitory effects of thimerosal and aristolochic acid on the outputs of PGE2 and 6-keto-PGF1 alpha were less marked, particularly on day 7 when the low output of PGE2 was unaffected and the output of 6-keto-PGF1 alpha was increased at the lower concentrations of thimerosal. This finding indicates that there are different pools of arachidonic acid bound as phospholipid for the syntheses of PGF2 alpha and 6-keto-PGF1 alpha by guinea-pig endometrium.  (+info)

Urothelial carcinoma associated with the use of a Chinese herb (Aristolochia fangchi) (8/122)

BACKGROUND: Chinese-herb nephropathy is a progressive form of renal fibrosis that develops in some patients who take weight-reducing pills containing Chinese herbs. Because of a manufacturing error, one of the herbs in these pills (Stephania tetrandra) was inadvertently replaced by Aristolochia fangchi, which is nephrotoxic and carcinogenic. METHODS: The diagnosis of a neoplastic lesion in the native urinary tract of a renal-transplant recipient who had Chinese-herb nephropathy prompted us to propose regular cystoscopic examinations and the prophylactic removal of the native kidneys and ureters in all our patients with end-stage Chinese-herb nephropathy who were being treated with either transplantation or dialysis. Surgical specimens were examined histologically and analyzed for the presence of DNA adducts formed by aristolochic acid. All prescriptions written for Chinese-herb weight-reducing compounds during the period of exposure (1990 to 1992) in these patients were obtained, and the cumulative doses were calculated. RESULTS: Among 39 patients who agreed to undergo prophylactic surgery, there were 18 cases of urothelial carcinoma (prevalence, 46 percent; 95 percent confidence interval, 29 to 62 percent): 17 cases of carcinoma of the ureter, renal pelvis, or both and 1 papillary bladder tumor. Nineteen of the remaining patients had mild-to-moderate urothelial dysplasia, and two had normal urothelium. All tissue samples analyzed contained aristolochic acid-related DNA adducts. The cumulative dose of aristolochia was a significant risk factor for urothelial carcinoma, with total doses of more than 200 g associated with a higher risk of urothelial carcinoma. CONCLUSIONS: The prevalence of urothelial carcinoma among patients with end-stage Chinese-herb nephropathy (caused by aristolochia species) is a high.  (+info)

Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). This review summarizes the significance of AA-derived DNA adducts in the aetiology of UUC leading to specific A:T to T:A transversion mutations (mutational signature) in AAN/BEN-associated tumours, which are otherwise rare in individuals with UCC not exposed to AA. Therefore, such DNA damage produced by AA-DNA adducts is one rare example of the direct association of exposure and cancer development (UUC) in humans, confirming that the covalent binding of carcinogens to DNA is causally related to tumourigenesis. Although aristolochic acid I (AAI), the major component of the natural plant extract AA, might directly cause interstitial nephropathy, enzymatic activation of AAI to reactive intermediates capable of binding to DNA is a necessary step leading to the formation of AA-DNA adducts and
Balkan endemic nephropathy (BEN) is found in certain rural areas of the Balkans and affects at least 25 000 inhabitants. Of the many hypotheses on BEN, the Aristolochia hypothesis has recently gained ground substantiated by the investigations on aristolochic acid nephropathy (AAN). On both clinical and morphological grounds, AAN is very similar to BEN. That exposure to aristolochic acid (AA) of individuals living in endemic areas through consumption of bread made with flour contaminated with seeds of Aristolochia clematitis is responsible for BEN is an old hypothesis, but one which is fully consistent with the unique epidemiologic features of BEN. Here, we propose an approach to investigate AA-induced mutagenesis in BEN that can provide molecular clues to the aetiology of its associated urothelial cancer. The molecular mechanism of AA-induced carcinogenesis demonstrates a strong association between DNA adduct formation, mutation pattern and tumour development. A clear link between urothelial ...
(HealthDay)-Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid (AA) found in Chinese herbs was first reported 20 years ago, AA-induced nephropathy remains ...
Aristolochic acid (AA) is a class of carcinogenic and nephrotoxic nitrophenanthrene carboxylic acids naturally found in Aristolochia plants. These plants have been widely used as herbal medicines and also enter the human food chain as the persistent soil pollutants. It has been known that AA exposure is implicated in multiple cancer types, kidney failure and ovarian dysfunction. However, whether AA exposure would influence the oocyte quality has not yet determined. Here, we document that AAI has the negative effects on the competency of oocyte maturation and fertilization. We show that AAI exposure leads to the oocyte meiotic failure via impairing the meiotic apparatus, displaying a prominently defective spindle assembly, actin dynamics and mitochondrial integrity. AAI exposure also causes the abnormal distribution of cortical granules and ovastacin, which is consistent with the observation that fewer sperm bound to the zona pellucida surrounding the unfertilized AAI-exposed eggs, contributing to the
BACKGROUND: Chinese herbs nephropathy is a new type of subacute interstitial nephropathy reported in women who had followed a slimming regimen including Chinese herbs. METHODS: We report the clinical presentation and follow-up of 15 cases and compare them with a control group of 15 women with interstitial nephropathies of other origins, matched for age, sex, and initial serum creatinine (mean 3 mg/dl). RESULTS: At presentation the Chinese herbs nephropathy group differed from the control group by a lower proteinuria (P = 0.009), a more severe anaemia (P = 0.002), and a higher prevalence of aortic insufficiency (42% vs 0%, P , 0.05). It was further characterized by mild hypertension in 80%, glycosuria and leukocyturia in 40% and asymmetric kidneys in 54% of the cases. During follow-up, deterioration of renal function was faster in the Chinese herbs nephropathy than in the control group (P , 0.05). It was influenced by the duration of Chinese herbs treatment (P = 0.037) and the delay between the ...
Larvae of the butterfly, Battus polydamas archidamas (Papilionidae: Troidini) feed exclusively on aristolochic acid (AAs)-containing Aristolochia species (Aristolochiaceae). The distribution of sequestrated AAs in the tissues (body, integument...
Eugene, OR (SafetyAlerts) - East Earth Herb, Inc. is recalling Jade Pharmacy brand Meridian Circulation tablets and liquid extract and Jade Pharmacy brand Quell Fire tablets because they may present a serious health hazard to consumers. The products contain aristolochic acid. Aristolochic acid is a potent carcinogen and nephrotoxin found in certain plants and botanicals. This chemical can cause serious kidney damage and the use of products that contain aristolochic acid has been associated with several occurrences of kidney failure. The use of aristolochic acid containing products has been linked to increased risk of kidney cancer in people who have consumed it.. Jade Pharmacy brand Meridian Circulation, and Jade Pharmacy brand Quell Fire were distributed throughout the United States through licensed health practitioners.. Meridian Circulation and Quell Fire are packaged under the Jade Pharmacy label. Meridian Circulation is available in bottles of 1 oz., 2 oz., and 4 oz. liquid extract and ...
We studied exposure-induced sensitivity changes in an identified taste cell from Manduca sexta, a herbivorous caterpillar. This taste cell occurs within the lateral styloconic sensillum and responds selectively to compounds that humans characterize as bitter (e.g. caffeine, salicin and aristolochic acid). We made extracellular recordings from several classes of identified taste cell within the lateral sensillum, both before and after dietary exposure (for 48 h) to a suprathreshold concentration of caffeine, salicin or aristolochic acid. Our results revealed (1) that dietary exposure to caffeine desensitized the bitter-sensitive taste cell to caffeine, whereas dietary exposure to salicin or aristolochic acid did not desensitize the same taste cell to salicin or to aristolochic acid; (2) that dietary exposure to caffeine failed to alter the responsiveness of the sugar-, salt- or inositol-sensitive taste cells within the same sensillum; (3) that the caffeine-induced desensitization phenomenon ...
A ristolochic acids (AAs) are powerful nephrotoxin and human carcinogen associated with chronic kidney disease and upper urinary tract urothelial carcinomas. ...
Aristolochic acid causes a specific nephropathy (AAN), Balkan endemic nephropathy, and urothelial malignancies. Using Western blotting suitable to determine protein expression, we investigated in several transgenic mouse lines expression of NAD(P)H:quinone oxidoreductase (NQO1)-the most efficient cytosolic enzyme that reductively activates aristolochic acid I (AAI). The mouse tissues used were from previous studies [Arlt et al., Chem. Res. Toxicol. 24 (2011) 1710; Stiborova et al., Toxicol. Sci. 125 (2012) 345], in which the role of microsomal cytochrome P450 (CYP) enzymes in AAI metabolism in vivo had been determined. We found that NQO1 levels in liver, kidney and lung of Cyp1a1⁻/⁻, Cyp1a2⁻/⁻ and Cyp1a1/1a2⁻/⁻ knockout mouse lines, as well as in two CYP1A-humanized mouse lines harboring functional human CYP1A1 and CYP1A2 and lacking the mouse Cyp1a1/1a2 orthologs, differed from NQO1 levels in wild-type mice. NQO1 protein and enzymic activity were induced in hepatic and renal ...
The spectrum of p53 mutations observed in transitional cell cancers of patients with EN is dominated by A:T → T:A transversions (Fig. 5 A). This result is consistent with the mutational spectra induced by AA-I (or by a mixture of AA-I and AA-II) in (i) the H-ras gene of rats (23, 24), (ii) transgenic rodent models (25, 26), (iii) the p53 gene in a urothelial cancer from a patient with AAN (34), (iv) site-specific mutagenesis studies in which a single dA-AL adduct is transfected into NER-deficient human cells (I.-Y. Yang and M.M., unpublished data), and (v) 9 of 11 immortalized mouse cell lines (Hupki cells) carrying the human p53 gene (27, 28). Indeed, the predominance of A:T → T:A transversions in the p53 mutational spectra may properly be regarded as a mutational signature (35) for human exposure to AA.. Confidence in our conclusion regarding AA and the etiology of EN rests, in part, on the biomarker data reported here and, in part, on studies of AAN in human populations, in particular, a ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Mutations in cancer cells leave a kind of fingerprint in the DNA of the cells called a mutational signature; each type of cancer has its own.. "When we look at mutational signatures in cancer cells, there is a lot of noise. The noise is something we simply do not know a lot about," says Larose. "Part of my experimental process is identifying new causes of that noise, and some of that might be gravity". Her theory is that some of the unknown "noise" in the cancer cells is there as a result of gravity. Since both healthy cells and cells with cancer are affected by gravity, the researchers should be able to detect this in the fingerprints in all our cells.. "Im looking for the molecular fingerprint for the gravitational force," she said, in part because it can help explain the meaning of some of the noise in the cancer cells.. Larose says that the mutational signature of gravity has never been studied or even proposed as a concept.. Although there is no gravity in space, there is cosmic ...
TP53 is one of the most commonly mutated genes in human tumours. Variations in the types and frequencies of mutations at different tumour sites suggest that they may provide clues to the identity of the causative mutagenic agent. A useful model for studying human TP53 mutagenesis is the partial human TP53 knock-in (Hupki) mouse containing exons 4-9 of human TP53 in place of the corresponding mouse exons. For an in vitro assay, embryo fibroblasts from the Hupki mouse can be examined for the generation and selection of TP53 mutations because mouse cells can be immortalized by mutation of Tp53 alone. Thus far, four environmental carcinogens have been examined using the Hupki embryo fibroblast immortalization assay: (a) UV light, which is linked to human skin cancer; (b) benzo[a] pyrene, which is associated with tobacco smoke-induced lung cancer; (c) 3-nitrobenzanthrone, a suspected human lung carcinogen linked to diesel exposure; and (d) aristolochic acid, which is linked to Balkan endemic ...
The Center for Theoretical Biological Physics PRESENTS Seminar Speaker Ludmil B. Alexandrov Oppenheimer Fellow Center for Nonlinear Studies Los Alamos National Laboratory Abstract: All cancers are caused by somatic mutations. These mutations may be the consequence of the intrinsic slight infidelity of the DNA replication machinery, exogenous or endogenous mutagen exposures, enzymatic modification of DNA, or defective DNA repair. In some cancer types, a substantial proportion of somatic mutations are known to be generated by exogenous carcinogens, for example, tobacco smoking in lung cancers and ultraviolet light in skin cancers, or by abnormalities of DNA maintenance, for example, defective DNA mismatch repair in some colorectal cancers. Each biological process causing mutations leaves a characteristic imprint on the genome of a cancer cell, termed, mutational signature. In this talk, I will present mutational signatures analyses encompassing 12, 023 cancer genomes across 40 distinct types of ...
Scientists have, for the first time, discovered how X-rays and radioactive particles cause cancer in humans by damaging DNA. Researchers from the Wellcome Trust Sanger Institute in the UK have been able to identify in human cancers two characteristic patterns of DNA damage caused by ionising radiation, such as gamma rays, X-rays and radioactive particles. these fingerprint patterns may now enable doctors to identify which tumours have been caused by radiation, and investigate if they should be treated differently. Previous work on cancer had shown that DNA damage often leaves a molecular fingerprint, known as a mutational signature, on the genome of a cancer cell. Researchers looked for mutational signatures in 12 patients with secondary radiation-associated tumours, comparing these with 319 that had not been exposed to radiation. "To find out how radiation could cause cancer, we studied the genomes of cancers caused by radiation in comparison to tumours that arose spontaneously," said Peter ...
... progressive chronic kidney disease (CKD). suppressed the immunoreactivity of mTOR signaling, which decreased the inflammatory responses and ECM accumulation in the obstructed kidneys. Isolated macrophages from rapamycin-treated obstructed kidneys presented less inflammatory activity than vehicle groups. In vitro study confirmed that rapamycin significantly inhibited the fibrogenic activation of cultured fibroblasts (NIH3T3 cells), which was induced by the stimulation of TGF-1. Further experiment revealed that rapamycin did not directly inhibit the fibrogenesis of HK2 cells with aristolochic acid treatment. Our findings clarified that rapamycin can ameliorate kidney fibrosis by blocking the mTOR signaling in interstitial macrophages and myofibroblasts. Introduction Tubulointerstitial fibrosis is the final common pathway of a wide variety of chronic progressive kidney diseases. Intense studies have focused on the molecular and ...
Carnitine may also interact with 2,3-Dimercapto-1-propanesulfonic acid, 3,4-Methylenedioxymethamphetamine (MDMA or ecstasy), acetaminophen, acetylcholinesterase (AChE) inhibitors, adefovir dipivoxil, adriamycin, agents for blood vessel width, agents for the ears, agents for the eyes, agents for the heart, agents for heart rate regulation, agents for the immune system, agents for the lungs, agents for the nervous system, agents for osteoporosis, agents for promoting urine flow, agents for retrovirus infections (HIV), agents for the stomach, agents toxic to the kidneys or liver, alcohol, alpha-interferon, Alzheimers agents, amiodarone, antibiotics, anticancer agents, antidepressants, anti-inflammatory agents, anti-seizure agents, aristolochic acid, azithromycin, beta blockers, bupivacaine, calcium channel blockers, carboplatin, cefepime, cephalosporins, cholesterol-lowering agents, cinnoxicam, cisplatin, clofibrate, cyclophosphamide, digoxin, doxorubicin, erythropoietin, exercise performance ...
DI-fusion, le Dépôt institutionnel numérique de lULB, est loutil de référencementde la production scientifique de lULB.Linterface de recherche DI-fusion permet de consulter les publications des chercheurs de lULB et les thèses qui y ont été défendues.
Jing is the source of life, health and longevity. We all are born with Jing Essence, which is stored in the Kidneys and which fuels all other energies. As we age, we naturally deplete our Jing essence; but chronic stress, illness and imbalance will exhaust our Jing faster than we can replenish it through foods and herbs. We must nourish Jing daily with acquired nutritive energy derived from healthy foods, water, meditation, exercise and Chinese herbs. To preserve and protect our Jing from depletion, we must avoid drug and alcohol abuse, bulimia or anorexia, excessive exercise and excessive sexual activities. The latter is especially important for men. Most healthy women dont have to worry so much about losing essence through sexual activity. For all women it is more important to preserve blood. Chinese medicine tells us that Blood and Jing Essence share the same source. Blood preservation is especially important for a woman because when she loses blood, she loses Jing. The wisdom of a womans ...
I spoke to a Kung Fu brother who was an acupuncturist and Chinese Herbalist. He advised me that some of the herbs on the list were not safe to use or unavailable within a western society. He recommended some alternatives that had the same healing properties, this was the birth of a unique but effective formula. I had created my own Dit Da Jow.. Keeping with tradition I also sought out a local Doctor and Chinese Herbalist. With her help and guidance, we formulated the unique blend of herbs that are still being today, that was over 10 years ago. ...
For some time now, I have been hearing a lot about the so called "ABC Miracle Drink". Basically juicing beetroot, carrot and an apple. The health benefits of these 3 ingredients are incredible. Numerous studies and research have been done on these ingredients and they have found that they literally slow down the formation and growth of cancer cells (hence naming it the Miracle drink). Chinese herbalists have also long been using it for its cancer preventative properties. And in one study, a Chinese herbalist gave it to his patient suffering from lung cancer, and had him drink it every day and after 3 months, he was cured of the disease! Among some of the health benefits that this juice has been effective in treating are: 1. Slows down the process/development of cancer. Restraining cancer cells from growing further. 2. Prevent liver, kidney and pancreas disease. (Reported to also cure ulcers.) 3. Strengthen the lungs, prevent heart attack and high blood pressure. 4. Strengthen the immune system ...
Heat: characterized by appearance of redness, burning or heat sensation, and symptom worsens with alcohol, anger/stress, hot/spicy food, and hot weather.. Wind: characterized by quick onset, and movement of symptoms to different areas of the body, itchiness, and aversion to wind.. Damp: characterized by oozing or weeping conditions, feeling of body heaviness. Dampness can also be an internally generated factor worsened by eating rich, oily or dairy foods.. Dry: characterized by scaly itchy skin which is worse in dry, winter or autumn weather.. Cold: characterized by open sores, purplish color, wet discharge and slow healing, and usually a chronic condition.. Q: How is the imbalance analyzed?. A: Important factors are considered before making each individual diagnosis and treatment plan. Aside from careful inspection of the exterior skin condition, relevant information includes the type of eruption, color, temperature, foods, activities, climates or emotions that affect the symptoms, details ...
Genome insertions and deletions (indels) show tremendous functional impacts despite they are much less common than single nucleotide variants, which are at the center of studies assessing cancer mutational signatures. We studied 8,891 tumor samples of 32 types from The Cancer Genome Atlas in order to explore those genes which are potentially implicated in cancer indels. Survival analysis identified in-frame indels as the most important variants predicting adverse outcome. Transcriptome-wide association study identified 16 genes overexpressed in both tumor samples and tumor types with high number of in-frame indels, of whom four (APOBEC1, BCL2L15, FOXL1, and PDX1) were identified with gene products distributed within the nucleus ...
Genome insertions and deletions (indels) show tremendous functional impacts despite they are much less common than single nucleotide variants, which are at the center of studies assessing cancer mutational signatures. We studied 8,891 tumor samples of 32 types from The Cancer Genome Atlas in order to explore those genes which are potentially implicated in cancer indels. Survival analysis identified in-frame indels as the most important variants predicting adverse outcome. Transcriptome-wide association study identified 16 genes overexpressed in both tumor samples and tumor types with high number of in-frame indels, of whom four (APOBEC1, BCL2L15, FOXL1, and PDX1) were identified with gene products distributed within the nucleus ...
Researchers use army of organoids to detect distinct mutational signature. A toxin produced by bacteria found in some probiotics - over-the-counter supplements used to treat conditions including irritable bowel and diarrhoea - has been linked to the development of bowel cancer. Writing in the journal Nature, researchers led by Hans Clevers at the Hubrecht Institute in Utrecht,…
Davidson PR, Sherborne AL, Taylor B, Nakamura AO, Nakamura JL. A pooled mutational analysis identifies ionizing radiation-associated mutational signatures conserved between mouse and human malignancies. Sci Rep. 2017;7(1):7645. doi: 10.1038/s41598-017-07888-0. PubMed PMID: 28794481; PMCID: PMC5550450.. Sherborne AL, Lavergne V, Yu K, Lee L, Davidson PR, Mazor T, Smirnoff IV, Horvai AE, Loh M, DuBois SG, Goldsby RE, Neglia JP, Hammond S, Robison LL, Wustrack R, Costello JF, Nakamura AO, Shannon KM, Bhatia S, Nakamura JL. Somatic and Germline TP53 Alterations in Second Malignant Neoplasms from Pediatric Cancer Survivors. Clin Cancer Res. 2017;23(7):1852-61. doi: 10.1158/1078-0432.CCR-16-0610. PubMed PMID: 27683180. A.L. Sherborne, P.R. Davidson, K. Yu, A.O. Nakamura, M. Rashid, J.L. Nakamura. Mutational analysis of ionizing radiation-induced neoplasms. Cell Rep. 2015 Sep 22;12(11):1915-26. doi: 10.1016/ j.celrep.2015.08.015. Epub 2015 Sep 3. PMID: 26344771.. R. Mroue, B. Huang, S. Braunstein, A. ...
Alexandrov LB, Kim J, Haradhvala NJ, Huang MNi, Ng AWei Tian, Wu Y, Boot A, Covington KR, Gordenin DA, Bergstrom EN et al.. 2020. The repertoire of mutational signatures in human cancer. Nature. 578(7793):94-101. ...
The mutational signature AC3, which has been associated with defects in homologous recombination repair (HRR), was detected in both sporadic meningioma and Mrad, but widely distributed across the genome in sporadic cases and enriched near genomic breakpoints in Mrad. Compared to the other MCs, the number of
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Bismillahirrahmanirrahim... Baiklah, dengan lapang dada saya berusaha mencoba menuliskan sebuah tulisan berjudul norak ini. He. Sebuah pekerjaan rumah yang belum sempat saya kerjakan dari uda Rangtalu. Semoga hasilnya tidak mengecewakan. 8O Aan Jaman Doeloe alias Aan Jadul, PR tentang masa-masa SD seorang Aan. GURU FAVORIT PR sulit ini mah. Pasalnya guru favorit saya adalah semua…
Li Ching Yuen was quite the extraordinary man. As a Chinese herbalist, he lived 256 years or 197 by his own account. Either way this is far more than is recognized as the maximum human life span.. ...
Li Ching Yuen was quite the extraordinary man. As a Chinese herbalist, he lived 256 years or 197 by his own account. Either way this is far more than is recognized as the maximum human life span.. ...
any hospital, government hospital is the cheapest, will have a blood pressure clinic. if all you want to do is monitor your blood pressure you can purchase a monitor, if you need medication and know what you need and the medication is sold over the counter then any pharmacy will do. if you want to lower your blood pressure without medication there is an acupuncture clinic at the government hospital and a Chinese herbalist on petchasem rd. if you want to take western herbs you can check the iherb.com website. they will ship to Thailand ...
Web:] http://www.freequality.org/beta%20freequal/fg%20%20site/training/GapAnalysis%5B2%5D.ppt [Datum van besoek: 3 Maart 2009] 1 November 2008.. Christo Bisschoff het in 1986 die graad B-Comm aan die destydse Universiteit van Port Elizabeth. Daarna sluit hy hom aan by die familie-boerdery op Steynsburg waar hy 5 jaar lank die posisie Bestuurder en Direkteur beklee. In dié tyd bekwaam hy homself verder deur aan die Universiteit van Suid Afrika die grade B-Comm (honneurs) (1989) en M-Comm (1990) te verwerf. Hy sluit aan by Noordwes Koöperasie as Senior landbou-ekonoom in 1991 en aanvaar in 1992 die pos as senior lektor aan die Universiteit van Pretoria. Hy voltooi sy doktorale studies in 1992 (Unisa) en aanvaar in 1995 die pos as professor in bemarking by die Potchefstroomse Besigheidskool aan die (huidige) Noordwes-Universiteit. Tydens sy loopbaan het hy verskeie nasionale en internasionale konferensies bygewoon, referate gelewer en artikels gepubliseer. Bykomend tot sy akademiese pligte is hy ...
Op de site een 20-tal Nederlandse patienten aan het woord over hun ervaringen met PEA. De klachten lopen uiteen van brandende voeten bij neuropathie, pijn bij MS tot gewrichtspijnen door artrose. … Source: Een twintigtal patienten aan het woord Brandende voeten en zenuwpijn
Suunto Movescount is een groeiende sportgemeenschap waar u uw eigen sportdagboek kunt creëren voor het bijhouden en delen van uw activiteiten en het aanpassen van uw horloge.. Ga als u het nog niet hebt gedaan naar www.movescount.com en meld u aan. Wanneer u een gebruikersaccount heeft, kunt u uw horloge op twee manieren verbinden aan uw account:. ...
Cookies zijn kleine tekstbestanden die worden opgeslagen in de browser van een gebruiker. De meeste cookies bevatten een unieke ID, een zogenaamde cookie-ID: een reeks tekens waarmee websites en servers worden gekoppeld aan de browser waarin de cookie wordt opgeslagen. Hierdoor kunnen websites en servers de browser onderscheiden van andere browsers die andere cookies opslaan, en kunnen ze elke browser herkennen aan de unieke cookie-ID.. Cookies worden veel gebruikt door websites en servers om veel van de basisservices te leveren die online beschikbaar zijn. Als u winkelt op een website, kan de website met een cookie onthouden welke items u heeft toegevoegd aan uw virtuele winkelwagen. Als u voorkeuren instelt op een website, kan de website met een cookie uw voorkeuren onthouden voor uw volgende bezoek aan de website. Of als u zich aanmeldt bij een website, kan de website een cookie gebruiken om uw browser later te herkennen, zodat u zich niet opnieuw hoeft aan te melden. Met cookies kunnen ...
Cookies zijn kleine tekstbestanden die worden opgeslagen in de browser van een gebruiker. De meeste cookies bevatten een unieke ID, een zogenaamde cookie-ID: een reeks tekens waarmee websites en servers worden gekoppeld aan de browser waarin de cookie wordt opgeslagen. Hierdoor kunnen websites en servers de browser onderscheiden van andere browsers die andere cookies opslaan, en kunnen ze elke browser herkennen aan de unieke cookie-ID.. Cookies worden veel gebruikt door websites en servers om veel van de basisservices te leveren die online beschikbaar zijn. Als u winkelt op een website, kan de website met een cookie onthouden welke items u heeft toegevoegd aan uw virtuele winkelwagen. Als u voorkeuren instelt op een website, kan de website met een cookie uw voorkeuren onthouden voor uw volgende bezoek aan de website. Of als u zich aanmeldt bij een website, kan de website een cookie gebruiken om uw browser later te herkennen, zodat u zich niet opnieuw hoeft aan te melden. Met cookies kunnen ...
wBuyBuy, Global ecommerce platform, maak online winkels gratis, verkoop produkte met 92 tale, verkoop aan almal oor die hele wêreld, koop van regoor die wêreld. wBuyBuy Global
PKI3CA enzym expressie bepalend voor verwacht resultaat van chemo behandeling bij borstkanker en is gerelateerd aan HER2 status en hormoonstatus. Dit blijkt uit tussenevaluatie van een gerandomiseerde biomarker studie bij totaal 737 patiënten. Artikel update 11 augustus 2014
Weet u hoe goedkoop Euroshopper vanille-ijs aan zijn vanillesmaak komt? Dankzij castoreum. Dat is een duur woord voor bevergeil. En dat woord zegt het al: u wordt genaaid. Rokers & parfumdragers idem trouwens, want die zuigen cq spuiten ook met bevergeil. Wist u niet hè? Nu wel. Volgende keer koopt u dus gewoon weer A-merk ijs bij Appie, en geen bevroren water dat op smaak is gebracht met beverkwak. Het Weet Wat Je Eet FeauteauF*ckje is van @MSteeman, die aan een serie eerlijke verpakkingen is begonnen. Na zijn bijdrage aan het uitrekenwerk van Fleur Agema dr neuqsekscyclus alweer zijn tweede quasigastblog op de GeenStijl vandaag. En ja, we weten dat het een D66er is. Maar dan geen kwaadaardige, zoals Peggold, wiens boodschap overigens óók geleverd zou moeten worden met een #eerlijkeverpakking-label. Maar dat terzijde. Zelf ook een intrigerend ingrediënt of eng E-nummer aangetroffen in de voorraadkast? Labelen die hap en aan de schranspaal er mee ...
Dear all, There are a few Alemtuzumab (Campath) abstracts being presented at the AAN conference in April. As someone who has had their two infusions - the last being 27 months ago, its quite comforting that the treatment effect seems ...
Download en installeer SuuntoLink op uw pc of Mac om uw horloge te synchroniseren met Movescount, uw GPS optimaal te houden en de software van uw horloge bij te werken.. Wij raden u aan uw horloge bij te werken wanneer er een nieuwe softwarerelease beschikbaar is.. Bezoek www.movescount.com/connect voor meer informatie.. ...
SIRT - Selectieve inwendige bestraling van levertumoren vooraf aan TACE - LITT geeft significant betere resultaten op levensduur bij inoperabele levertumoren. Artikel update 26 juli 2013.
Waxaan halkan hoose idinkula wadaagayaa 7 fikradood iyo mid suubis ah, oo aan ka faaiiday akhrinta buugga Awoodda Caadada Haddu Eebbe yidhaahdo
A lively format with AAN Sections debating controversies related to specific section topics and featuring two speakers arguing a side of the topic, followed by a rebuttal and question and answer period ...
Honoré betekend eer, Welke keuze maak jij dat jouw eer aan doet? Jarenlang heb ik andere mensen de ruimte gegeven om keuzes voor mij te laten maken. Het gevolg van mijn keuze om deze ruimte te bieden was dat andere controle over mijn leven kregen. Naast mijn werk als coach, familie-opsteller kreeg ik nog niet het inzicht waar de finesse van mijzelf zat. Met de tools van #Accessconsciousness , Bars, Bodyprocessen en classes is mijn leven hierin totaal veranderd. Graag inspireer ik jou om de keuze te maken die jouw eer aan doet! Als Bars- class facilitator, Bodyprocess- class facilitator organaniseer ik geregeld classes door geheel Nederland.. Daarnaast ben ik een Abuse on Hold practitioner, waardoor je ook een Abuse onhold process kunt boeken, naast allerlei andere processen die ik aanbied.. Welke ruimte, energie en bewustzijn kan het jouw opleveren om een class of een process bij Honoré te boeken wat jouw eer aan doet in jouw process?. ...
Door een virale infectie functioneert een getransplanteerde nier minder goed. Naast immuuncellen (T-cellen) leveren ook nierepitheelcellen een actieve bijdrage aan zon ontstekingsreactie. Kristin Heutinck toont aan dat deze cellen over specifieke receptoren beschikken die dubbelstrengs-RNA (dsRNA) herkennen. dsRNA fungeert als waarschuwingsteken voor de aanwezigheid van een virus en zet nierepitheelcellen aan tot productie van cytokines en interferonen. Deze signaalstoffen spelen een essentiële rol bij het alarmeren van het immuunsysteem en het remmen van virale vermenigvuldiging in de cel. Daarnaast beïnvloedt dsRNA de expressie van eiwitten die geprogrammeerde celdood (apoptose) veroorzaken. T-cellen ruimen virusgeïnfecteerde cellen op door apoptose te induceren. De gevoeligheid van nierepitheelcellen voor aanvallen van T-cellen verandert na herkenning van dsRNA ...
Kinky seks zal uiteenlopende dingen betekenen voor verschillende mensen. Wat voor een bepaald koppel explosief kan lijken, kan saai en vervelend voor een ander stel zijn. Om die reden hebben we dan ook besloten om een top 50 van leuke en kinky ideeën samen te stellen voor eigenlijk alle geliefden, ongeacht of het nu gaat om de nieuwelingen of om de doorgewinterde experts op het gebied van vrijen zijn.. Indien je nog maar net komt kijken in de wereld van de wat kinky seks, dan kun je een paar tips uit de volgende kinky lijst gaan uitproberen en zien wat dit voor je liefdesleven kan betekenen. Ben je echter eerder een kinky veteraan, dan zijn we er zeker van dat er hieronder toch nog een heleboel tips te vinden zijn die je nog altijd niet hebt geprobeerd. Dus ga er gewoon mee aan de slag en wellicht vind je iets leuks wanneer een bijzondere draai geeft aan je vrijpartij.. Maar voordat we je met de genoemde top 50gaan confronteren, willen we je wel waarschuwen, al kunnen we maar al te goed ...
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De Tarmac Expert is net als de S-Works modellen opgebouwd aan de hand van het Rider-First Engineered™ ontwerp. Door elk frame afzonderlijk te ontwerpen, beschikt elke framemaat over dezelfde ongeëvenaarde klim- en daalprestaties die je van een Tarmac mag verwachten. Voor de afmontage hebben we gekozen voor onderdelen met een uitstekende prijs-kwaliteitverhouding, zoals betrouwbare DT Swiss R460 Pro wielen, Shimano Ultegra 6800 onderdelen en een selectie aan Body Geometry componenten om jou nog beter te laten presteren.
Menig kinderhartje slaat weer sneller vandaag. vanavond is het pakjesavond en zullen er weer tevreden kindertjes in hun bedjes kruipen vanavond. Toch is het feest wel degelijk veranderd en hebben de computerspelletjes zo stiekem aan de overhand gekregen. Dit viel me op toen ik met mijn oudste dochter te winkelen was voor de sinterklaas inkopen. Een zwaar geïrriteerde vader stond onder druk van zijn familie en de tijd aan de toonbank. Hij had een aantal dagen geleden namelijk bot gevangen en het personeel gevraagd om dit specifieke spel voor hem terzijde te houden. Door de grote drukte had het personeel nog geen tijd gevonden om dit te checken en moest men tijdens dit grote moment van drukte op zoek naar zijn spelletje. Eenmaal gevonden werd het spelletje vakkundig ingepakt en werd het bedrag van €89,- afgerekend. En de man liep zonder een woord te zeggen de winkel uit. Het had in mijn ogen weinig meer met het gezellige kinderfeest te maken. Ik had mijn dochter een bepaald budget aangemeten. ...
Wat me direct opviel als ik deze cocktail aan het maken was, was de grote hoeveelheid citroen- en limoensap en had me aan een enorm zure cocktail verwacht, maar dit viel eigenlijk best wel mee. De cocktail is wel zuur, maar best aangenaam doordat de zuurte was verzacht wordt door de siroop en de zoete smaken van beide rums. Zeker eentje om eens te maken ...
Een geheel belangrijke factor in het werk van iedereen bedrijf leven de conferentie van koeriers om al die andere kwesties door het fabriek te behalen. Managers delen informatie betreffende alle evenementen, ontwikkelen strategieën om aandoeningen te resultaat of lossen ze met als ze al leven. Dergelijke vergaderingen moeten productief zijn daarbovenop soms horen het frustratie zijn, evenals qua organisatie als qua gedrag. Bezoekers aan je conferentie trachten wat tijdsbestek uit uw boekingsschema bij halen. Ook gebeurt gij soms dat werknemers deelnemen aan vergaderingen, maar ze weten niets eens echtpaar er door een bepaalde afdeling gebeurt of merken helemaal genkel tijd ongeveer een toch probleem bij bestuderen. Maar moderne technologieën maken jouwe leven ervoor ons eenvoudiger, zelfs wanneer het begint te om meerderjarige bedrijven. Zeker hebben we een handige en ongecompliceerd te toepassen oplossing, vooral voor diegenen onder ons die sporadisch op afstand moeten opereren of frequent ...
Royaal 3-kamer appartement met balkon op het westen, gelegen aan het Amsterdam-Rijnkanaal! - Royaal 3-kamer appartement met balkon op het westen,
rapid, warn and up-to-day. The new supervisor is de facto around the ball. op en wakker, aan die brand name, wakker يَقِظ، مُنْتَبِه، واعٍ бърз alerta na výši auf Draht på mærkerne; hurtig i vendingen; kvik γρήγορος, ενημερωμένος, σε ετοιμότητα estar al tanto, estar alerta tasemel هشیار و کاردان بودن ajan tasalla à la hauteur לִהְיוֹת בָּעִנייָנִים सावधान, किसी स्थिति से पूर्ण सम्पर्क रखना pripravan gyors siap siaga klár, með á nótunum aggiornato 有能である 빈틈 없이 kupinas naujų idėjų maleīgs; veikls peka bijdehand rask i vendingen/avtrekket; med på lekenbystry, zorientowany هوښيار او كارپوه alerta prompt, pe fază толковый na úrovni na nivoju u toku på alerten ตื่นตัว; กระตือรือร้น uyanık, olup bitenden haberdar 戰戰競競 спритний چاق ...
In het kader van de Klimaat- en Energieverkenning (KEV) zijn ramingen gemaakt voor 2020, 2025 en 2030 van i) niet aan energie gerelateerde emissies uit de landbouw naar de lucht, in de vorm van methaan (CH4), lachgas (N2O), ammoniak (NH3), stikstofoxide (NOx), fijnstof (PM10 en PM2,5) en NMVOS (niet-methaan vluchtige organische stoffen) en ii) emissies van kooldioxide (CO2) en N2O door landgebruik, landgebruiksveranderingen en bosbouw (LULUCF). Het jaar 2017 is het basisjaar in de ramingen. De ramingen gaan uit van vastgesteld beleid en van naleving van onderliggende wet- en regelgeving. De peildatum voor het vastgestelde beleid in de raming is 1 mei 2019. De onzekerheden zijn in beeld gebracht voor de factoren met een groot effect op de emissies in 2030. In de raming is de CH4-emissie in 2030 met ruim 32 miljoen kg CH4 afgenomen ten opzichte van 2017 (6,4%). Deze afname wordt veroorzaakt door een afname van het aantal melkkoeien en jongvee. De geraamde N2O-emissie in 2030 is bijna 1 miljoen kg ...
Hoera, roepen mijn kinderen blij als ze de eerste kindertjes met hun lampionnetjes voorbij zien komen. Met de jongste moet papa mee als begeleiding want ja als je nog geen vier bent, is dit allemaal reuzespannend natuurlijk. Het zingen is nog niet zo luid maar het grabbelen naar het snoepgoed hebben we al na de 2de deur in de vingers. Net voordat we vertrekken stortten er dikke hagelstenen uit de lucht en besluiten we om in ieder geval regenkleding aan te trekken. Gelukkig valt er bijna niets uit de lucht tijdens onze lampionnen strooptocht. Al is het wel winterskoud buiten en hebben we verkleumde vingers als we thuiskomen en dan hebben we maar een klein rondje met een paar andere kinderen uit de buurt gedaan. De "grote" zus is met een vriendinnetje onderweg met het doel voor ogen om het halve dorp van zijn snoepgoed af te helpen. Wat me wel opvalt is dat het Sint Maarten lopen een van de weinige tradities is die nog niet is aangetast door de commercie, zoals Sinterklaas en Kerst. Zelfs ...
Zoals u weet heeft Rockmed tot grote tevredenheid van haar afnemers meer dan 300 mobiele operatiestoelen aan verschillende instellingen geleverd. Rockmed heeft het bestaande concept op een aantal essentiële punten sterk verbeterd in de nieuwe iMoc Ophtha innovated mobile operation chair.. Deze nieuwe stoel is nu uitgerust met o.a.:. ...
DEZE WONING WORDT MET VOORRANG AANGEBODEN AAN SOCIALE HUURDERS VAN DE ALLIANTIE TOT 21 OKTOBER 2017 Een verrassend ingedeelde woning in een rustig
Mense het mos die gewoonte om jou skeef aan te kyk wanneer jy vertel van n dier wat jou uit éie wil kies vir die belewenis van n leeftyd. Daar is mos te veel die diere wie se gees op wrede wyse vir die mens se genot gebreek word. Maar Skollie, d...
Shop en kies uit onze grote selectie van Tassen en fietshoezen . Wij bieden u een geweldige selectie van Thule aan. Koop tegen scherpe prijzen uw fiets uitrusting bij bikeinn. Spoedige levering & betrouwbare betaalmogelijkheden bij bikeinn.
E-le-o-no-ra S-pi-na en Mi-che-le Be-nig-net-ti, die wyd ge-roem-de I-ta-li-aan-se kla-vier-paar wat al tal-le pry-se vir hul du-ospel ont-vang het, rond hul Suid-A-fri-kaan-se kon-sert-toer af met twee op-tre-des dié na-week in P-re-to-ria en Jo-han-nes-burg. Die slot-kon-sert is Dins-dag in Pot-chef-stroom.. Die twee Gau-teng-kon-ser-te be-staan uit n pro-gram vir vier han-de op een kla-vier, ter-wyl die Pot-chef-stroom-kon-sert op twee kla-vie-re uit-ge-voer word.. Mô-re-aand om 19:00 tree hul-le op in die Tau-ro-me-ni-um, Wa-ter-kloof-rif, P-re-to-ria. Die re-per-to-ri-um be-staan uit die Fan-ta-sie in f, K 608 van Mo-zart, Ra-ch-ma-ni-noff se Ses Stukke, o-pus 11, die Fan-ta-sie in F, D 940 in vier aan-een-lo-pen-de be-we-gings van S-chu-bert, as-ook die A-me-ri-kaan-se kom-po-nis Sa-mu-el Bar-ber se Sui-te, o-pus 28, waar-in die kom-po-nis sy her-in-ne-rin-ge aan die New York van sy jeug koes-ter.. Kaar-tjies vir dié kon-sert kan voor-af be-spreek word by John Roos by 082 770 6138. ...
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আপনি এটা নিতে মনে রাখবেন, এটা এখন একটি ভাল সময়. যেমন হল্যান্ড হিসাবে বড় ব্রান্ডের & ব্যারেট ও স্বাস্থ্য স্প্যানের এটি সংরক্ষণ, of bieden hun eigen assortiment aan - wat geruststellend is, কারণ আপনার নিশ্চিন্ত থাকা যাবে তারা বিশুদ্ধতা সংক্রান্ত কঠোর ইইউ নির্দেশিকা মেনে চলতে যে, ডোজ এবং দূষণকারী. একই স্বাধীন অনলাইন খুচরো জন্য বলেন করা যাবে না, সুতরাং তাদের সাপের তেল থেকে দূরে থাকতে. ...
Juryrapport Drs. G.J. Bollen, oud Universitair Hoofddocent aan het Laboratorium voor Fytopathologie van de LUW, heeft op het gebied van de gewasbescherming zowel nationaal als internationaal uitzonderlijke bijdragen geleverd op met name het gebied van onderwijs en onderzoek. In Nederland was Bollen één van de eersten die het belang van plantpathogene bodemorganismen onderkende en hierdoor is hij, als leermeester-onderzoeker, mede de grondlegger van een Nederlandse school van bodemfytopathologen. Hij leverde in totaal 36 studenten af die een afstudeeronderwerp bij hem hadden gedaan, en hij begeleidde een achttal promovendi. Voor Bollen hield de begeleiding echter niet op bij de buluitreiking. Het gemak waarmee hij benaderd kon worden voor plantenziektekundige vragen was groot. Voor velen was en is hij dè vraagbaak op het terrein van bodempathogenen. Overigens beperkten deze vragen zich vaak niet tot de bodempathogenen. Op onderwijskundig gebied was Bollen zijn tijd ver vooruit. Dit blijkt ...
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De HvA inspireert studenten om met creatieve oplossingen en duurzame innovaties aan de toekomst te werken; om vandaag te verbinden met morgen.
Was het een leuk of goed of spannend of mooi of fijn boek? Dan geef het maar door aan een vriend. Vond je het minder, dan zet het maar terug waar je het gevonden hebt. ...
The Silent Force Fanclub heeft haar activiteiten gestaakt. Het forum blijft wel gewoon bestaan. Houd je aan de regels en veel plezier op het forum. The Silent Force Fanclub has ceased their activities but the Forum will remain to exist. Please play by the rules and we wish you a lot of fun ...
Anthony Martin raadt een verantwoorde consumptie van zijn bieren aan. Door deze website te betreden, erkent U de wettelijke Leeftijd te hebben voor alcohol-consumptie. Bier met liefde gebrouwen, drinkt men met verstand. ...
Anthony Martin raadt een verantwoorde consumptie van zijn bieren aan. Door deze website te betreden, erkent U de wettelijke Leeftijd te hebben voor alcohol-consumptie. Bier met liefde gebrouwen, drinkt men met verstand. ...
Terwijl Dirk zijn reputatie aan het redden is, zit Pieter Lakeman van de stichting Hypotheekleed met een dikke sigaar te balen voor de tv. Hij riep iedereen op geld weg te halen bij de club van Dirk. Woensdag ging hij in De Wereld Draait Door al uit zijn dak tegen Yvon Jaspers. Is Dirk de kat met drie levens, Lakeman de gebeten hond ...
Het kabinet vergadert al de hele dag over de reactie op het Irak-rapport van de commissie-Davids. Boycot de coalitie het verzoek van de oppositie om met Balkenende te spreken over het rapport? SP wil debatteren, GroenLinks ook maar PvdA, CDA en ChristenUnie willen het rustig aan doen. Best spannend ...
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... Wond- en Huidverzorging is een zelfzorgproduct voor het verzorgen van huidontvellingen, verwondingen, lichte irritaties, sneeën alsook de onbeschadigde huid. Draagt bij aan het versnellen van het natuurlijke genezingsproces door de wonden, sneeën en beschadigingen schoon te maken.
1. Dhaenens C. Aristolochia: The malignant lie and the benign truth. J Register Chin Herbal Med 2013;10:39-41. 2. Dhaenens C. Aristolochia - die bösartige Lüge und die gutartige Wahrheit. Naturheilpraxis 2016;69:65-8. 3. Debelle FD, Vanherweghem JL and Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008;74:158-69. 4. De Broe ME. On a nephrotoxic and carcinogenic slimming regimen. Am J Kidney Dis 1999;33:1171-3. 5. Wiebrecht A. Über die Aristolochia-Nephropathie. Dt Zschr Akupunktur 2000;43:187-97. 6. Gökmen MR, Cosyns JP, Arlt VM, et al. The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review. Ann Intern Med 2013;158:469-77. 7. Pena JM, Borras M, Ramos J and Montoliu J. Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 1996;11:1359-60. 8. Yang L, Su T, Li XM, et al. Aristolochic acid nephropathy: variation in presentation and ...
1. Dhaenens C. Aristolochia: The malignant lie and the benign truth. J Register Chin Herbal Med 2013;10:39-41. 2. Dhaenens C. Aristolochia - die bösartige Lüge und die gutartige Wahrheit. Naturheilpraxis 2016;69:65-8. 3. Debelle FD, Vanherweghem JL and Nortier JL. Aristolochic acid nephropathy: a worldwide problem. Kidney Int 2008;74:158-69. 4. De Broe ME. On a nephrotoxic and carcinogenic slimming regimen. Am J Kidney Dis 1999;33:1171-3. 5. Wiebrecht A. Über die Aristolochia-Nephropathie. Dt Zschr Akupunktur 2000;43:187-97. 6. Gökmen MR, Cosyns JP, Arlt VM, et al. The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review. Ann Intern Med 2013;158:469-77. 7. Pena JM, Borras M, Ramos J and Montoliu J. Rapidly progressive interstitial renal fibrosis due to a chronic intake of a herb (Aristolochia pistolochia) infusion. Nephrol Dial Transplant 1996;11:1359-60. 8. Yang L, Su T, Li XM, et al. Aristolochic acid nephropathy: variation in presentation and ...
Acute uric acid nephropathy (AUAN, also acute urate nephropathy) is a rapidly worsening (decreasing) kidney function (renal insufficiency) that is caused by high levels of uric acid in the urine (hyperuricosuria). Acute uric acid nephropathy is usually seen as part of the acute tumour lysis syndrome in patients undergoing chemotherapy or radiation therapy for the treatment of malignancies with rapid cell turnover, such as leukemia and lymphoma. It may also occur in these patients before treatment is begun, due to spontaneous tumor cell lysis (high incidence in Burkitts lymphoma). Acute uric acid nephropathy can also be caused by an acute attack of gout. Acute uric acid nephropathy is caused by deposition of uric acid crystals within the kidney interstitium and tubules, leading to partial or complete obstruction of collecting ducts, renal pelvis, or ureter. This obstruction is usually bilateral, and patients follow the clinical course of acute renal failure. The picture of acute renal failure is ...
A simple and rapid capillary zone electrophoresis (CZE) method for the determination of aristolochic acid (AA) in dietary supplements and selected herbs is described. A clear separation of AA from other sample constituents was achieved within 5 minutes without any sample clean up. A mixture of 20 mM-morpholinethanesulphonic acid+10 mM-BisTrisPropane+0.2% hydroxyethylcelullose in 10% methanol serves as a background electrolyte. The linearity, accuracy, intra-assay and detection limit of the developed method are 200-6000 ng/mL, 95-103%, 3.5%, and 50 ng/ml, respectively. Ease of use, sufficient sensitivity and low running cost are the most important attributes of the CZE method. The proposed CZE method was compared with HPLC ...
In previous reports, more than 100 phytochemical compounds of different Aristolochia species have been analyzed with their biological activities (Kuo et al., 2012; Wu et al., 2004), but total phytochemical study of the root, stem, leaf, and fruit of A. clematitis and other species of the genus has not been carried out. Aristolochia species showed antibacterial and antifungal effects against various microorganisms, such as Aristolochia indica against S. aureus, Staphylococcus epidermidis, Bacillus megaterium, E. coli, Salmonella Typhi, and Vibrio cholerae (Farhana et al., 2016), Aristolochia bracteolata for Aspergillus flavus and Botrytis cinerea (Trayee et al., 2016), or A. trilobata, A. brevipes, Aristolochia monticola Brandegee and Aristolochia kristsagathra against S. aureus (Camporese et al., 2003; Moorthy et al., 2015; Murillo-Alvarez et al., 2001). Among the identified compounds, such as 7,9 dimethoxytariacuripyrone, licarin A and B have antimicrobial effect out of AAs (Kuo et al., ...
Headline: Bitcoin & Blockchain Searches Exceed Trump! Blockchain Stocks Are Next!. New report on global Urinary Tract Cancer market is segmented on the basis of types, diagnostic techniques, treatment procedures and geography. On the basis of types urinary tract cancer market is further categorized into Urothelial carcinoma, Squamous cell carcinoma, Adenocarcinoma and others. Among the urinary tract cancer types, urothelial carcinoma is the most-prevalent with ~90% to 95% occurrence rate, globally. Based on diagnostic techniques it is segmented into Cystoscopy, Urine analyses, Transurethral resection of tumor and Imaging tests. Being a part of initial evaluation in diagnosis of any urinary tract cancer, cytoscopy is the most important investigation for bladder cancer. Segmentation on the basis of treatment procedures categorizes the market into Surgery, Intravesical therapy, Chemotherapy, and Radiation therapy. Geographically, the global urinary tract cancer market is segmented into North ...
In the present study, we elucidated whether all hTAS2R genes are expressed in gustatory tissue and, hence, whether the entire hTAS2R gene family might serve as taste receptors. Previous studies demonstrated that all functionally analyzed TAS2Rs respond to substances known to taste bitter to humans [hTAS2R4, denatonium benzoate (Chandrashekar et al., 2000); hTAS2R7, strychnine (Sainz et al., 2007); hTAS2R10, strychnine (Bufe et al., 2002); hTAS2R14, picrotoxin (Behrens et al., 2004); hTAS2R16, salicin (Bufe et al., 2002); hTAS2R38, 6-n-propyl-2-thiouracil (Kim et al., 2003; Bufe et al., 2005); hTAS2R43/44, aristolochic acid (Kuhn et al., 2004); hTAS2R47, 6-nitrosaccharin (Pronin et al., 2004); only single compounds listed for each receptor] or aversive to rodents [mouse T2R5, cycloheximide; mouse T2R8, denatonium benzoate (Chandrashekar et al., 2000); rat T2R9, cycloheximide (Bufe et al., 2002)]. These findings support the conclusion that most likely all TAS2Rs are indeed bitter sensors. However, ...
Substances, mixtures and exposure circumstances in this list have been classified by the International Agency for Research on Cancer (IARC) as Group 1: The agent (mixture) is carcinogenic to humans. The exposure circumstance entails exposures that are carcinogenic to humans. This category is used when there is sufficient evidence of carcinogenicity in humans. Exceptionally, an agent (mixture) may be placed in this category when evidence of carcinogenicity in humans is less than sufficient but there is sufficient evidence of carcinogenicity in experimental animals and strong evidence in exposed humans that the agent (mixture) acts through a relevant mechanism of carcinogenicity. 2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, and plants containing them Arsenic and inorganic arsenic compounds1 Asbestos Azathioprine Benzene Benzidine, and dyes metabolized to Benzo[a]pyrene Beryllium and beryllium compounds2 Chlornapazine ...
Earlier this week, the U.S. Department of Health and Human Services (HHS) added eight substances to its Report on Carcinogens. The 12th Report on Carcinogens now includes a grand total of 240 listings. HHS added formaldehyde and aristolochic acids as "known human carcinogens" and listed captafol, cobalt-tungsten carbide (in powder or hard metal form), certain inhalable glass wool fibers, o-nitrotoluene, riddelliine, and styrene as substances that are "reasonably anticipated to be human carcinogens.". The report was prepared for HHS by the National Toxicology Program (NTP). It identifies agents, substances, mixtures, or exposures in two categories, (a) known to be a human carcinogen, and (b) reasonably anticipated to be a human carcinogen. That said, whether known or anticipated, the development of cancer really depends on exposure and individual susceptibility.. Considering the focus of this site - sustainable homes, natural materials, and green technology - readers should pay attention to the ...
found in cocoa).1 Herbs containing aristolochic acid actually do cause cancer, because they contain enough of it to be harmful. Cocoa, on the other hand, contains such a small amount of safrole that it is harmless. Its all about the amounts. The dose makes the poison. California requires certain products to have labels saying "This product contains chemicals known to the State of California to cause cancer and birth defects or other reproductive harm." This is a completely useless statement. Its irrelevant whether something contains carcinogens; whats important is whether it contains enough of it to be dangerous. Somebody on Slashdot once joked that when theyre a billionaire, theyll launch a blimp to block out the sun that says: "The sun is known to the state of California to cause cancer" - which is perfectly true! You can write entire articles on the supposed evils of any substance by stating scary facts. (The DHMO hoax very skilfully parodied this kind of chemophobic fear mongering.) For ...
Dong, W.; Matsumura, F.; Kullman, S.W. (2010). TCDD induced pericardial edema and relative COX-2 expression in medaka (Oryzias latipes) embryos. Toxicol. Sci. 118 (1), 213-223.. Fujisaw, N.; Nakayama, S.M.M.; Ikenaka, Y.; Ishizuka, M. 2014. TCDD-induced chick cardiotoxicity is abolished by a selective cyclooxygenase-2 (COX-2) inhibitor NS398. Arch. Toxicol. 88, 1739-1748.. Huang, C.C.; Chen, P.C.; Huang, C.W.; Yu, J. (2007). Aristolochic acid induces heart failure in zebrafish embryos that is mediated by inflammation. Toxicol. Sci. 100, 486-494.. Teraoka, H.; Kubota, A.; Kawai, Y.; Hiraga, T. (2008). Prostanoid signaling mediates circulation failure caused by TCDD in developing zebrafish. Interdis. Studies Environ. Chem. Biol. Resp. Chem. Pollut. 61-80.. Teraoka, H.; Okuno, Y.; Nijoukubo, D.; Yamakoshi, A.; Peterson, R.E.; Stegeman, J.J.; Kitazawa, T.; Hiraga, T.; Kubota, A. (2014). Involvement of COX2-thromboxane pathway in TCDD-induced precardiac edema in developing zebrafish. Aquat. Toxicol. ...
* found in: Biapenem, Astilbin, Allicin, aqueous solution, Aristolochic Acid B, Aflatoxin B2, Antimycin A, Aflatoxin M1, 7-Aminoactinomycin D, Aztreonam,..
0137] The at least one used anti-inflammatory, antiproliferative, antiangiogenic, antirestenotic (anti-restenosis), antineoplastic, antimigrative and/or antithrombogenic active agent is preferably selected from the group comprising or consisting of: abciximab, acemetacin, acetylvismione B, aclarubicin, ademetionine, adriamycin, aescin, afromosone, akagerine, aldesleukin, amidorone, aminoglutethimide, amsacrine, anakinra, anastrozole, anemonin, anopterine, antimycotics, antithrombotics, apocymarin, argatroban, aristolactam-All, aristolochic acid, ascomycin, asparaginase, aspirin, atorvastatin, auranofin, azathioprine, azithromycin, baccatin, bafilomycin, basiliximab, bendamustine, benzocaine, berberine, betulin, betulinic acid, bilobol, bisparthenolidine, bleomycin, bombrestatin, Boswellic acids and its derivatives, bruceanol A, B and C, bryophyllin A, busulfan, antithrombin, bivalirudin, cadherins, camptothecin, capecitabine, o-carbamoyl-phenoxyacetic acid, carboplatin, carmustine, celecoxib, ...
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Over thousands of years of clinic practice, CM showed assured effectiveness for ESRD (end stage kidney disease). And yet why people still believe the rumor saying Chinese herb containing element that would damage the kidney or Chinese Herb Nephropathy (CHN
For the most accurate results, please enter a full postcode into the search box so we can determine your exact location. If you type in a town name or the first part of a postcode the results will be ordered by distance from the centre of that town.. ...
For the most accurate results, please enter a full postcode into the search box so we can determine your exact location. If you type in a town name or the first part of a postcode the results will be ordered by distance from the centre of that town.. ...
You might recognize this as an amazingly large-flowered specimen of the group of vines known as Dutchmans pipes, or birthworts, genus Aristolochia, often grown in gardens, and with native species occurring in much of North America and the tropics. This giant-flowered species is ARISTOLOCHIA GRANDIFLORA, commonly called Brazilian Dutchmans Pipe or Giant Pelican Flower. Its a member of the Dutchmans Pipe or Birthwort Family, the Aristolochiaceae, native to Central and South America, but planted in the tropics and subtropics worldwide. Instead of the flowers consisting of the usual calyx and corolla, they produce a corolla-like calyx, or perianth. The perianths unusual U-shaped tubes helps the flower with its pollination. The blossoms strong fragrance entice insects, mostly flies, to enter the yellow opening, and descend the tube. In the above picture you can see that the tube constricts at its bottom, then opens into a larger chamber. This makes it harder for the pollinator to find the way ...
Cancer is when cells in the body grow out of control, often forming a mass or tumor. In upper urinary tract cancer, abnormal cells are found in the renal pelvis, renal calyces and/or ureters.
... aristolochic acid. Even though aristolochic acid has been found to expedite and arouse the activity of white blood cells, speed ... Aristolochic acid is a very dangerous compound in that this acid is a potent mutagen and carcinogen that can cause urological ... Aristolochia macrophylla contains the natural substance aristolochic acid. Aristoclochic acid is found in all plants of the ... Consumption of aristolochic acid can also induce uterine bleeding. Because of this, the FDA has warned consumers to avoid ...
Since aristolochic acid has low water solubility, water decoction is believed to be a safer route than taking guang fang ji as ... "A Success Story on Aristolochic Acid". Chen JK & Chen TT (2004). Chinese Medical Herbology and Pharmacology. City of Industry, ... In May, 2000, the FDA began detaining any plants or medicines suspected of containing aristolochic acid, unless laboratory ... the resultant guang fang ji preparations can contain toxic amounts of aristolochic acid Ingestion can lead to renal failure and ...
Aristolochic acid was linked to aristolochic acid-associated urothelial cancer in a Taiwanese study in 2012. In 2013, two ... Metabolites of aristolochic acid enter the cell nucleus and form adducts on DNA. While adducts on the transcribed DNA strand ... 2009) Aristolochic acid nephropathy: An environmental and iatrogenic disease. In: Fishbein, J. C. (ed.) Advances in Molecular ... 2012). "Aristolochic acid-associated urothelial cancer in Taiwan". Proceedings of the National Academy of Sciences. 109 (21): ...
Aristolochic acid-associated urothelial cancer in Taiwan. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/ ... β-aminobutyric acid, γ-aminobutyric acid, ephedrine, trigonelline, phytosterols and glucoronic acid. Care should be taken as ... However - they are of little medicinal value and contain the carcinogen aristolochic acid. The over-use of this plant family in ... The bark of white willow contains salicin, which is a chemical similar to aspirin (acetylsalicylic acid). It is thought to be ...
2007). "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proc. Natl. Acad. Sci. U.S.A. 104 (29): 12129-34. ... Aristolochic-acid-containing herbal remedies used in traditional Chinese medicine are associated with a related-possibly ... In the Balkan region, dietary aristolochic acid exposure may come from the consumption of the seeds of Aristolochia clematitis ... De Broe ME (March 2012). "Chinese herbs nephropathy and Balkan endemic nephropathy: toward a single entity, aristolochic acid ...
"Aristolochic Acid: FDA Warns Consumers to Discontinue Use of Botanical Products that Contain Aristolochic Acid". US Food and ... The plant contains aristolochic acid, a carcinogenic compound. The United States Food and Drug Administration warns that ... consumption of aristolochic acid-containing products is associated with "permanent kidney damage, sometimes resulting in kidney ...
The plant contains aristolochic acid, a carcinogenic compound. The United States Food and Drug Administration warns that ... but should not be used as a substitute because it contains an unknown concentration of the carcinogen aristolochic acid and ... consumption of aristolochic acid-containing products is associated with "permanent kidney damage, sometimes resulting in kidney ...
This plant contains aristolochic acid, a toxic alkaloid. The vining plant is native to southernand western South America. It is ... Aristolochia littoralis prefers acid-neutral soils (pH 5.5 - 7.0) and average moisture, in part sun to shade, at an elevation ...
The link between renal failure and aristolochic acid, which the plant contains, was discovered after a clinic for obesity in ... Broe, M. E. D. (2012). "Chinese herbs nephropathy and Balkan endemic nephropathy: Toward a single entity, aristolochic acid ... "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proceedings of the National Academy of Sciences. 104 (29 ...
2012 Aristolochic Acid, FDA Recall of Herbs and Herbal Products. January 2001 Mayway Sotore Herbal Archived February 24, 2012, ... Caution is required; injuries are linked to aristolochic acid contained in some species of this family, as in Belgium incorrect ...
... contains the carcinogenic chemical compounds aristolochic acid and derivatives. The plant also contains ...
A. rotunda contains aristolochic acids which are carcinogenic, mutagenic, and nephrotoxic. Aristolochia rotunda subsp. rotunda ... Eating the leaves of the plant the larvae this insect ingest aristolochic acid that make them poisonous to birds. This plant is ... "Plants Containing Aristolochic Acid" (PDF). International Agency for Research on Cancer. Tela Botanica / 2000-2009 - Le réseau ...
The plant contains a toxic substance, aristolochic acid. The larvae sequester the toxin, and both the juvenile and adult ... doi:10.1046/j.0021-8790.2001.00568.x. Fordyce, James A. (2000). "A model without mimic: Aristolochic acids from the California ... butterflies have high and toxic concentrations of the aristolochic acid in their tissues. Throughout the range of the species, ...
Some phytochemicals are known phytotoxins that are toxic to humans; for example aristolochic acid is carcinogenic at low doses ... which include phenolic acids, flavonoids, and stilbenes/lignans. Flavonoids can be further divided into groups based on their ...
Plants of the family Aristolochiaceae contain aristolochic acids in their leaves and stems. This is believed to be a potent ...
Aristolochic acid, a compound found in plants of the Aristolochiaceae family, also causes DNA mutations and is a cause of liver ... Andersson, 2011: p. 134 "Mutation signatures implicate aristolochic acid in bladder cancer development". Genome Medicine. 7 (1 ...
Being in the Aristolociaceae family, Aristolochia chilensis contain aristolochic acid. This has typically been used in ... However, the use of this acid for medicinal purposes has been banned in Europe since 2001 and China in 2003 due to studies ... Caterpillars can especially tolerate the acids contained within the plant and, in turn, cause them to become poisonous to ... showing that the acids are carcinogenic, mutagenic, and nephrotoxic, thus causing much more harm then good. Although they do ...
"Aristolochic Acid: FDA Concerned About Botanical Products, Including Dietary Supplements, Containing Aristolochic Acid". FDA. ...
Aristolochic acid presence may also act as an oviposition chemical stimulant. The pipevine swallowtail larva has few natural ... the level of acid in the body of the butterflies rises as the acid accumulates. High levels of acid make the larvae and adults ... As a result of bird predation, this butterfly has evolved a chemical defense using the aristolochic acids found in their host ... All host plants for the pipevine swallowtail have some form of aristolochic acids, which the larva sequesters while they feed. ...
Members of the family Aristolochiaceae contain aristolochic acid, which has been recognized as a carcinogen. In a study on its ... Schaneberg, B. T.; Applequist, W. L.; Khan, I. A. (2002). "Determination of aristolochic acid I and II in North American ...
"Aristolochic Acid: FDA Warns Consumers to Discontinue Use of Botanical Products that Contain Aristolochic Acid". U.S. Food and ... However, the FDA warns against consuming Asarum, as it is nephrotoxic and contains the potent carcinogen aristolochic acid. The ... "Determination of aristolochic acid I and II in North American species of Asarum and Aristolochia". Pharmazie. 57 (10): 686-9. ...
Aristolochic acid inhibits inflammation induced by immune complexes and non-immunological agents (carrageenan or croton oil).[ ... citation needed] Aristolochic acid inhibits the activity of snake venom phospholipase (PLA2) by forming a 1:1 complex with the ...
15 (1): 5-8. CS1 maint: Uses authors parameter (link) Tian-Shung Wu, Yann-Lii Leu and Yu-Yi Chan (2000). Aristolochic Acids as ... and they sequester toxins such as aristolochic acid in their bodies. This makes the adults toxic to vertebrate predators such ...
Transition Aristolochic acid, a natural plant chemical causing A:T transversions in humans Futuyma, D.J. (2013). Evolution (3rd ... Also, transitions are less likely to result in amino acid substitutions (due to wobble base pair), and are therefore more ... in deoxyribonucleic acid (DNA). It can only be reversed by a spontaneous reversion. Although there are two possible ... a transition is more likely to encode for the same amino acid. Transversions can be spontaneous, or can be caused by ionizing ...
The use of this plant poses a risk as it contains the toxin aristolochic acid which is carcinogenic. The USDA has banned all ... "Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on ... and aristolochia group of alkaloids with nucleic acid structures and biological perspectives". Medicinal Research Reviews. 27 ( ...
2-Naphthylamine Acetaldehyde associated with consumption of alcoholic beverages 4-Aminobiphenyl Aflatoxins Aristolochic acids, ... analgesic mixtures containing Plants containing aristolochic acid Polychlorinated biphenyls, dioxin-like Processed meats, ... strong-acid process) Glass, making of Magenta dyes, manufacture of Painting (see benzene) Paving and roofing with coal tar ... occupational exposure associated with Acid mists, strong inorganic Aluminium production Auramine production Boot and shoe ...
Determination of aristolochic acid I in botanicals and dietary supplements potentially contaminated with aristolochic acid I ... Determination of aristolochic acid I in botanicals and dietary supplements potentially contaminated with aristolochic acid I ... Determination of aristolochic acid I in botanicals and dietary supplements potentially contaminated with aristolochic acid I ... Determination of aristolochic acid I in botanicals and dietary supplements potentially contaminated with aristolochic acid I ...
Non-aristolochic acid prescribed Chinese herbal medicines and the risk of mortality in patients with chronic kidney disease: ... Aristolochic acid-induced upper tract urothelial carcinoma in Taiwan: clinical characteristics and outcomes. Int J Cancer 2013; ... 1981 drugs containing aristolochic acid were banned by the Deutsches Bundesgesundheitsamt (German Health-Agency), after a ... Aristolochic acid-associated urothelial cancer in Taiwan. Proc Natl Acad Sci U S A 2012;109:8241-6 ...
Aristolochic acid-associated urothelial carcinoma. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ... Aristolochic acid-associated urothelial carcinoma. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ... DNA adducts of aristolochic acid II: Total synthesis and site-specific mutagenesis studies in mammalian cells. Nucleic Acids ... Aristolochic acid-associated urothelial cancer in Taiwan. Chung-Hsin Chen, Kathleen G. Dickman, Masaaki Moriya, Jiri Zavadil, ...
The best-known herb-induced chronic kidney disease is aristolochic acid nephropathy. Aristolochic acid i... (Source: SafetyLit ... Herbs and hazards: risk of Aristolochic acid nephropathy in Iran - Ardalan MR, Khodaie L, Nasri H, Jouyban A.. Herbs are ... Aristolochic Acids News This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to ... The connection between kidney cancer and the use of aristolochic acid. There is aan apparent link between exposure to ...
aristolochic acid (mixture of AA-I and AA-II);. AAN,. aristolochic acid nephropathy;. AL,. aristolactam;. dA-AL-I,. 7-( ... Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Arthur P. Grollman, Shinya Shibutani, Masaaki Moriya, ... Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Arthur P. Grollman, Shinya Shibutani, Masaaki Moriya, ... Aristolochic acid and the etiology of endemic (Balkan) nephropathy Message Subject (Your Name) has sent you a message from PNAS ...
Since aristolochic acid is a mutagen, it does damage over time. Patients are often first diagnosed with aristolochic acid ... Excretion of aristolochic acids and their metabolites is through the urine. The exact mechanism of action of aristolochic acid ... Aristolochic acids are metabolized by oxidation and reduction pathways, or phase I metabolism. Reduction of aristolochic acid I ... containing aristolochic acid. The agency warned that consumption of aristolochic acid-containing products was associated with " ...
Aristolochic Acid in the Etiology of Renal Cell Carcinoma.. Hoang ML1, Chen CH2, Chen PC3, Roberts NJ1, Dickman KG4,5, Yun BH6 ... Aristolochia species used in the practice of traditional herbal medicine contains aristolochic acid (AA), an established human ...
Table 1: Effects of 0.5 mg/kg aristolochic acid sodium (AANa) treatment on p-aminohippuric acid in rabbits . ... Aristolochic acid sodium (AANa, containing 41% AAI and 56% AAII), p-aminobenzoic acid potassium salt (≥99%), and p- ... Figure 1: Plasma concentrations of p-aminohippuric acid (PAH) after iv administration of 0.5 mg/kg aristolochic acid sodium ( ... Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. Chiao-Shih Tseng, Shih-Ming ...
Pharmacokinetics of p-Aminohippuric Acid and Inulin in Rabbits with Aristolochic Acid Nephropathy. Chiao-Shih Tseng, Shih-Ming ... The characteristics of aristolochic acid nephropathy (AAN) are interstitial fibrosis and atrophy of the proximal tubules, but ... After a single intravenous administration of 0.5 mg/kg aristolochic acid sodium (AANa), rabbits exhibited mild to moderate ... To investigate the effects of AA on renal functions and the pharmacokinetics (PKs) of p-aminohippuric acid (PAH) and inulin, ...
F. D. Debelle, J. L. Nortier, E. G. De Prez et al., "Aristolochic acids induce chronic renal failure with interstitial fibrosis ... F. D. Debelle, J.-L. Vanherweghem, and J. L. Nortier, "Aristolochic acid nephropathy: a worldwide problem," Kidney ... L. Yang, X. Li, and H. Wang, "Possible mechanisms explaining the tendency towards interstitial fibrosis in aristolochic acid- ... Dahuang Fuzi Decoction Attenuates Renal Fibrosis and Ameliorates Mitochondrial Dysfunction in Chronic Aristolochic Acid ...
Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid (AA) ... "Aristolochic acid nephropathy, a global health problem" March 19, 2013 https://medicalxpress.com/news/2013-03-aristolochic-acid ... Aristolochic acid nephropathy, a global health problem. March 19, 2013 in Medicine & Health / Diseases, Conditions, Syndromes ... Although the first description of a rapidly progressive nephropathy associated with the consumption of aristolochic acid found ...
A systematic assessment of the content of aristolochic acids in the most widely used species is needed to evaluate whether ... Local uses of Aristolochia species and content of nephrotoxic aristolochic acid 1 and 2--a global assessment based on ... highlighted the risk of using preparations which contain aristolochic acids. On the other hand anecdotal evidence highlights ...
... is the main compound of the naturally occurring carcinogen aristolochic acid. Previous studies showed that AAI is directly ... Aristolochic Acid Ames Test Tumorigenicity Assay 61st Codon Carcinogenic Form These keywords were added by machine and not by ... Mengs, U., Lang, W. and Poch, J.A., 1982, The carcinogenic action of aristolochic acid in rats, Arch. Toxicol., 51:107CrossRef ... 1989) Aristolochic Acid I Induced Tumors in Wistar Rats Contain Activating Mutations in Codon 61 of the H-ras Protooncogene. In ...
Although aristolochic acid I (AAI), the major component of the natural plant extract AA, might directly cause interstitial ... is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases ... Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN ... Keywords: aristolochic acid; carcinogenicity; mutagenesis; nephrotoxicity; DNA adduct formation aristolochic acid; ...
A ristolochic acids (AAs) are powerful nephrotoxin and human carcinogen associated with chronic kidney disease and upper ... Aristolochic acid I (AA-I) is the most abundant type of the aristolochic acids. Published data suggest that AA-I is a substrate ... Renal elimination of aristolochic acid I in the isolated perfused kidney model. ... A ristolochic acids (AAs) are powerful nephrotoxin and human carcinogen associated with chronic kidney disease and upper ...
Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc. Natl. Acad. Sci. U.S.A. 104, 12129-12134 (2007).. ... Aristolochic acid-associated urothelial cancer in Taiwan. Proc. Natl. Acad. Sci. U.S.A. 109, 8241-8246 (2012).. ... Mutational signature of aristolochic acid exposure as revealed by whole-exome sequencing. Sci. Transl. Med. 5, 197ra102 (2013). ... Aristolochic acid (AA) is a natural compound found in many plants of the Aristolochia genus. Aristolochia plants are commonly ...
Aristolochic acid (AA) is a potent nephrotoxin and carcinogen (IARC Group 1) associated with urothelial, hepatobiliary, and ... Abstract 4252: New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean ... New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean patients: Implications ... Abstract 4252: New molecular evidence associating exposure to aristolochic acid with urothelial cancers in South Korean ...
... detection of aristolochic acids in Aristolochia and Asarum species by using a monoclonal antibody against aristolochic acids I ... Feng C, Xie X, Wu M, Li C, Gao M, Liu M, Qi X and Ren J: Tanshinone I protects mice from aristolochic acid I-induced kidney ... Aristolochic acid (AA) is a component present in Chinese herbs (for example Asarum and Aristolochia) from remedies for the ... Wu TK, Wei CW, Pan YR, Cherng SH, Chang WJ, Wang HF and Yu YL: Vitamin C attenuates the toxic effect of aristolochic acid on ...
Singapore, 19 October 2017 - Scientists from Singapore and Taiwan have revealed a decisive link between Aristolochic Acids (AA ... Singapore-Taiwan Team Reveal Link between Many Liver Cancers and Herbal Remedies Containing Aristolochic Acid. ...
2007). Aristolochic acid and the etiology of endemic (Balkan) nephropathy. Proc Natl Acad Sci USA 104, 12129-12134.CrossRef ... 2017). Aristolochic acids and their derivatives are widely implicated in liver cancers in Taiwan and throughout Asia. Sci ... Enrichment of AT-TA transversion at 5′-CAG-3′ motif is not a unique mutational signature of Aristolochic acid. ... repairing nucleic acid alkylation damage and beyond. J Biol Chem 290, 20734-20742.CrossRefGoogle Scholar ...
Aristolochic acid is an herb used in many varieties of Chinese herbs and health supplements. Interestingly, it also can cause a ... Patients with aristolochic acid toxicity are also prone to developing malignancies of the urinary tract (e.g. bladder cancer). ... ACEi/ARB (13) acid-base (45) acute kidney injury (77) amyloidosis (12) ANCA-associated disease (20) anemia of chronic kidney ...
What is aristolochic acid? Meaning of aristolochic acid medical term. What does aristolochic acid mean? ... Looking for online definition of aristolochic acid in the Medical Dictionary? aristolochic acid explanation free. ... aristolochic acid still is found in products sold in the US.. aristolochic acid. C17H11NO7, an acid derived from Aristolochia, ... aristolochic acid. Also found in: Dictionary, Thesaurus, Legal, Encyclopedia, Wikipedia. aristolochic acid. Pseudomedicine. A ...
Introduction: Aristolochic acid I, a potent human nephrotoxic and carcinogenic compound produced by aristolochia plants, it is ... Abstract:Introduction: Aristolochic acid I, a potent human nephrotoxic and carcinogenic compound produced by aristolochia ... Keywords:Aristolochic acid, flour, fruit, high-performance liquid chromatography, microextraction, urine.. ... A Microextraction Liquid-Chromatographic Determination of Aristolochic Acid I in Urine, Flour, and Aristolochiaceae Fruit. ...
... method for the determination of aristolochic acid (AA) in dietary supplements and selected herbs is described. A clear ... A mixture of 20 mM-morpholinethanesulphonic acid+10 mM-BisTrisPropane+0.2% hydroxyethylcelullose in 10% methanol serves as a ... aristolochic acid food supplement herbs slimming capillary zone electrophoresis aristolochic acid food supplement herbs ... A simple and rapid capillary zone electrophoresis (CZE) method for the determination of aristolochic acid (AA) in dietary ...
... feed exclusively on aristolochic acid (AAs)-containing Aristolochia species (Aristolochiaceae). The distribution of ... PRIESTAP H.A. 1987: Minor aristolochic acids from Aristolochia argentina and mass spectral analysis of aristolochic acids. ... MIX D.B., GUINAUDEAU H. & SHAMMA M. 1982: The aristolochic acids and aristolactams. J. Nat. Prod. 45: 657-665 Go to original ... Sequestration of aristolochic acids from meridic diets by larvae of Battus polydamas archidamas (Papilionidae: Troidini). ...
  • But de Broe only writes, that the vaso-constrictive properties of serotonin might have "accelerated or potentiated" the nephrotoxic effects of aristolochic acid which he did not question. (ctca.center)
  • In this study, A. clematitis was selected to evaluate the aristolochic acids I and II (AA I and AA II) concentrations and the antimicrobial activity of methanol, hexane, butanol, and ethyl acetate extracts of the root, stem, leaf, root, and fruit. (akjournals.com)
  • Patients with aristolochic acid toxicity are also prone to developing malignancies of the urinary tract (e.g. bladder cancer). (blogspot.com)
  • BALACHANDRAN P., WEI F., LIN R.C., KHAN I.A. & PASCO D.S. 2005: Structure activity relationships of aristolochic acids analogues: toxicity in cultured renal epithelial cells. (eje.cz)
  • Using metabonomics, an emerging dynamic technique that allows an effective mapping of alterations in endogenous metabolites levels in biofluids and tissues, we evaluated early signs of renal toxicity from extra urine samples collected in a rat model of intoxication with aristolochic acids. (omicsonline.org)
  • It is also used to recover lead from used lead-acid batteries, and as an oral chelation agent to clean up heavy metal toxicity. (healthy-eating-politics.com)
  • The caterpillars are also unappealing to most predators due to their toxicity: the vines which the caterpillars feed upon contain aristolochic acid, a poisonous compound known to be carcinogenic in rats. (wikipedia.org)
  • Aristolochic acid can also be used in the treatment of acute and serious infections such as TB, hepatitis, liver cirrhosis and infantile pneumonia. (pfaf.org)
  • A study reported in the Science Translational Medicine journal in October 2017 reported high incidences of liver cancer in Asia, particularly Taiwan, which bore the "well-defined mutational signature" of aristolochic acids. (wikipedia.org)
  • C 4 H 7 NO 4 , a nonessential amino acid that is a product of pancreatic digestion. (thefreedictionary.com)
  • C 4 H 7 NO 4 , a nonessential amino acid. (tabers.com)
  • Using this method, we discovered potential histopathological diagnosis biomarkers (including lipids, amino acids, choline, peptides and carnitine) from 52 postoperative lung cancer tissue samples and then subsequently used these biomarkers to generate images for rapid and label-free histopathological diagnosis. (nature.com)
  • An acid labile branched PDMAEMA/acetal copolymer with amino group was synthesized by the DE-ATRP and followed by Michael addition. (biomedsearch.com)
  • System L is a major transport system for cellular uptake of neutral amino acids. (nii.ac.jp)
  • Among system L transporters, L-type amino acid transporter 1 (LAT1) is responsible for the nutrient uptake in cancer cells, whereas L-type amino acid transporter 2 (LAT2) is a transporter for non-cancer cells. (nii.ac.jp)
  • Also, transitions are less likely to result in amino acid substitutions (due to wobble base pair), and are therefore more likely to persist as "silent substitutions" in populations as single nucleotide polymorphisms (SNPs). (wikipedia.org)
  • A transversion usually has a more pronounced effect than a transition because the third nucleotide codon position of the DNA, which to a large extent is responsible for the degeneracy of the code, is more tolerant of transition than a transversion: that is, a transition is more likely to encode for the same amino acid. (wikipedia.org)
  • J.R. Ioset, G.E. Raoelison and K. Hostettmann: "An LC/DAD-UV/MS method for the rapid detection of aristolochic acid in plant preparations", Planta Med. (edu.pl)
  • Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats," Journal of the American Society of Nephrology , vol. 13, no. 2, pp. 431-436, 2002. (hindawi.com)
  • A systematic assessment of the content of aristolochic acids in the most widely used species is needed to evaluate whether their uses pose a potential health risk. (nih.gov)
  • Aristolochic acid (AA)-containing compounds have been used as antiviral, antibacterial, anti-inflammatory, anti-neoplastic, and slimming agents [ 1 , 2 ] for a long time. (kjim.org)
  • C 20 H 32 O 2 , an omega-6 fatty acid formed by the action of enzymes on phospholipids in cell membranes. (thefreedictionary.com)
  • in diabetic ketoacidosis, when the conversion of fatty acids to ketones increases. (tabers.com)
  • Poly((R)-3-hydroxybutyrate-co-(R)-3-hydroxyhexanoate) [P(3HB-co-3HHx)], a flexible and practical kind of polyhydroxyalkanoates, is generally produced from plant oils and fatty acids by several wild and recombinant bacteria. (biomedsearch.com)
  • It is a building block or proteins, participates in the citric acid and urea cycles, and is a neurotransmitter. (tabers.com)
  • Significant epidemiologic features of EN include its focal occurrence in certain villages, a familial but not inherited pattern of disease, initial manifestation after residence in an endemic village for 15 years or more ( 6 ), and strong association with upper urinary tract transitional cell (urothelial) cancer ( 7 ). (pnas.org)