The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.
A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.
Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.
A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
A mutant strain of Rattus norvegicus used in research on renal function and hypertension and as a disease model for diabetes insipidus.
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
Hormones released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). They include a number of peptides which are formed in the NEURONS in the HYPOTHALAMUS, bound to NEUROPHYSINS, and stored in the nerve terminals in the posterior pituitary. Upon stimulation, these peptides are released into the hypophysial portal vessel blood.
Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).
The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
The withholding of water in a structured experimental situation.
Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.
A drive stemming from a physiological need for WATER.
Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS.
Hypothalamic nucleus overlying the beginning of the OPTIC TRACT.
Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
Aquaporin 6 is an aquaglyceroporin that is found primarily in KIDNEY COLLECTING DUCTS. AQP6 protein functions as an anion-selective channel.
Nucleus in the anterior part of the HYPOTHALAMUS.
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC
Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.
Drugs used to cause constriction of the blood vessels.
The condition that results from excessive loss of water from a living organism.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The ability of the kidney to excrete in the urine high concentrations of solutes from the blood plasma.
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
Injections into the cerebral ventricles.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
A class of porins that allow the passage of WATER and other small molecules across CELL MEMBRANES.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The consumption of liquids.
A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Compounds with BENZENE fused to AZEPINES.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Excessive amount of sodium in the blood. (Dorland, 27th ed)
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Raised area at the infundibular region of the HYPOTHALAMUS at the floor of the BRAIN, ventral to the THIRD VENTRICLE and adjacent to the ARCUATE NUCLEUS OF HYPOTHALAMUS. It contains the terminals of hypothalamic neurons and the capillary network of hypophyseal portal system, thus serving as a neuroendocrine link between the brain and the PITUITARY GLAND.
Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
Fluids composed mainly of water found within the body.
Tendency of fluids (e.g., water) to move from the less concentrated to the more concentrated side of a semipermeable membrane.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Sodium excretion by URINATION.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A pathological condition manifested by failure to perfuse or oxygenate vital organs.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Elements of limited time intervals, contributing to particular results or situations.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.
Liquid components of living organisms.
An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.
The U-shaped portion of the renal tubule in the KIDNEY MEDULLA, consisting of a descending limb and an ascending limb. It is situated between the PROXIMAL KIDNEY TUBULE and the DISTAL KIDNEY TUBULE.
Solutions that have a greater osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.
An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
The circulation of the BLOOD through the vessels of the KIDNEY.
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
The rate dynamics in chemical or physical systems.
A reagent that is highly selective for the modification of arginyl residues. It is used to selectively inhibit various enzymes and acts as an energy transfer inhibitor in photophosphorylation.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID.
Disturbances in the body's WATER-ELECTROLYTE BALANCE.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
A ubiquitous sodium salt that is commonly used to season food.
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC
The nonstriated involuntary muscle tissue of blood vessels.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Sense of awareness of self and of the environment.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Established cell cultures that have the potential to propagate indefinitely.

Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy. (1/1807)

The purpose of this study was to determine the specificity and concentration of oxytocin (OT) and arginine vasopressin (AVP) binding sites in non-pregnant (NP) human and rhesus monkey endometrium, myometrium and fibromyomas, and to determine the cellular localization of OT receptor (OTR). Besides [3H]AVP, [125I]LVA, a specific VP1 receptor subtype antagonist, was used to determine vasopressin receptor (VPR) concentrations. Samples were obtained from 42 pre-menopausal and three pregnant women (5, 13 and 35 weeks gestation), and several NP and pregnant monkeys. Specificity of binding was assessed in competition experiments with unlabelled agonists and antagonists of known pharmacological potency. Cellular localization of OTR was determined by immunohistochemistry. In NP human uterine tissues, [3H]AVP was bound with higher affinity and greater binding capacity than [3H]OT, whereas in pregnant women and in NP and pregnant rhesus monkeys, uterine OT binding capacity was greater. OT and AVP binding sites discriminated very poorly between OT and AVP; [125I]LVA binding sites were more selective than [3H]AVP. Their ligand specificity and binding kinetics indicated the presence of two distinct populations of binding sites for OT and AVP in primate uterus. Endometrium of NP women and monkeys had low OTR and VPR concentrations. Myometrial and endometrial OTR and VPR were down-regulated in midcycle and in early human pregnancy, they were up-regulated in the secretory phase and second half of pregnancy. Immunoreactive OTR in NP uterus was localized in patches of myometrial muscle cells and small numbers of endometrial epithelial cells.  (+info)

Physiological variability of fluid-regulation hormones in young women. (2/1807)

We tested the physiological reliability of plasma renin activity (PRA) and plasma concentrations of arginine vasopressin (P[AVP]), aldosterone (P[ALD]), and atrial natriuretic peptide (P[ANP]) in the early follicular phase and midluteal phases over the course of two menstrual cycles (n = 9 women, ages 25 +/- 1 yr). The reliability (Cronbach's alpha >/=0.80) of these hormones within a given phase of the cycle was tested 1) at rest, 2) after 2.5 h of dehydrating exercise, and 3) during a rehydration period. The mean hormone concentrations were similar within both the early follicular and midluteal phase tests; and the mean concentrations of P[ALD] and PRA for the three test conditions were significantly greater during the midluteal compared with the early follicular phase. Although Cronbach's alpha for resting and recovery P[ANP] were high (0.80 and 0.87, respectively), the resting and rehydration values for P[AVP], P[ALD], and PRA were variable between trials for the follicular (alpha from 0.49 to 0.55) and the luteal phase (alpha from 0.25 to 0. 66). Physiological reliability was better after dehydration for P[AVP] and PRA but remained low for P[ALD]. Although resting and recovery P[AVP], P[ALD], and PRA were not consistent within a given menstrual phase, the differences in the concentrations of these hormones between the different menstrual phases far exceeded the variability within the phases, indicating that the low within-phase reliability does not prevent the detection of menstrual phase-related differences in these hormonal variables.  (+info)

Effects of arginine vasopressin on cell volume regulation in brain astrocyte in culture. (3/1807)

Astrocytes initially swell when exposed to hypotonic medium but rapidly return to normal volume by the process of regulatory volume decrease (RVD). The role that arginine vasopressin (AVP) plays in hypotonically mediated RVD in astrocytes is unknown. This study was therefore designed to determine whether AVP might play a role in astrocyte RVD. With the use of 3-O-[3H]methyl-D-glucose to determine water space, AVP treatment resulted in significantly increased 3-O-methyl-D-glucose water space within 30 s of hypotonic exposure (P = 0.0001) and remained significantly elevated above baseline (1. 75 microliter/mg protein) at 5 min (P < 0.021). In contrast, in untreated cells, complete RVD was achieved by 5 min. At 30 s, cell volume with AVP treatment was 37% greater than in cells that received no treatment (2.9 vs. 2.26 microliter/mg protein, respectively; P < 0.006). The rate of cell volume increase (dV/dt) over 30 s was highly significant (0.038 vs. 0.019 microliter. mg protein-1. s-1 in the AVP-treated vs. untreated group; P = 0.0004 by regression analysis). Additionally, the rate of cell volume decrease over the next 4.5 min was also significantly greater with vasopressin treatment (-dV/dt = 0.0027 vs. 0.0013 microliter. mg protein-1. s-1; P = 0.0306). The effect of AVP was concentration dependent with EC50 = 3.5 nM. To determine whether AVP action was receptor mediated, we performed RVD studies in the presence of the V1-receptor antagonists benzamil and ethylisopropryl amiloride and the V2-receptor agonist 1-desamino-8-D-arginine vasopressin (DDAVP). Both V1-receptor antagonists significantly inhibited AVP-mediated volume increase by 40-47% (P < 0.005), whereas DDAVP had no stimulatory effects above control. Taken together, these data suggest that AVP treatment of brain astrocytes in culture appears to increase 3-O-methyl-D-glucose water space during RVD through V1 receptor-mediated mechanisms. The significance of these findings is presently unclear.  (+info)

AVP inhibits LPS- and IL-1beta-stimulated NO and cGMP via V1 receptor in cultured rat mesangial cells. (4/1807)

The present study examined how arginine vasopressin (AVP) affects nitric oxide (NO) metabolism in cultured rat glomerular mesangial cells (GMC). GMC were incubated with test agents and nitrite, and intracellular cGMP content, inducible nitric oxide synthase (iNOS) mRNA, and iNOS protein were analyzed by the Griess method, enzyme immunoassay, and Northern and Western blotting, respectively. AVP inhibited lipopolysaccharide (LPS)- and interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner, with concomitant changes in cGMP content, iNOS mRNA, and iNOS protein. This inhibition by AVP was reversed by V1- but not by oxytocin-receptor antagonist. Inhibition by AVP was also reproduced on LPS and interferon-gamma (IFN-gamma). Protein kinase C (PKC) inhibitors reversed AVP inhibition, whereas PKC activator inhibited nitrite production. Although dexamethasone and pyrrolidinedithiocarbamate (PDTC), inhibitors of nuclear factor-kappaB, inhibited nitrite production, further inhibition by AVP was not observed. AVP did not show further inhibition of nitrite production with actinomycin D, an inhibitor of transcription, or cycloheximide, an inhibitor of protein synthesis. In conclusion, AVP inhibits LPS- and IL-1beta-induced NO production through a V1 receptor. The inhibitory action of AVP involves both the activation of PKC and the transcription of iNOS mRNA in cultured rat GMC.  (+info)

Local regulation of vasopressin and oxytocin secretion by extracellular ATP in the isolated posterior lobe of the rat hypophysis. (5/1807)

It is now widely accepted that ATP functions as a signalling substance in the nervous system. The presence of P2 receptors mediating the action of extracellular ATP in brain regions involved in hormonal regulation raises the possibility that a similar role for ATP might also exist in the neuroendocrine system. In this study, the release from the rat isolated neurohypophysis preparation of endogenous ATP, oxytocin and vasopressin (AVP) were measured simultaneously using luciferin-luciferase and RIA techniques. After 70 min preperfusion, electrical field stimulation caused a rapid increase in the amount of ATP in the effluent and the release of AVP and oxytocin also increased stimulation-dependently. Inhibition of voltage-dependent Na+ channels by tetrodotoxin (1 microM) reduced the stimulation-evoked release of AVP and oxytocin; however, the evoked release of ATP remained unaffected. The effect of endogenous ATP on the hormone secretion was tested by suramin (300 microM), the P2 receptor antagonist. Suramin significantly increased the release of AVP, and the release of oxytocin was also enhanced. ATP, when applied to the superfusing medium, decreased the release of AVP, but not that of oxytocin, and its effect was prevented by suramin. ATP (60 nmol), added to the tissues, was readily decomposed to ADP, AMP and adenosine measured by HPLC combined with ultraviolet light detection, and the kinetic parameters of the enzymes responsible for inactivation of ATP (ectoATPase and ecto5'-nucleotidase) were also determined (Km=264+/-2.7 and 334+/-165 microM and vmax=6.7+/-1.1 and 2.54+/-0.24 nmol/min per preparation (n=3) for ectoATPase and ecto5'-nucleotidase respectively). Taken together, our data demonstrate the stimulation-dependent release, P2 receptor-mediated action and extracellular metabolism of endogenous ATP in the posterior lobe of the hypophysis and indicate its role, as a paracrine regulator, in the local control of hormone secretion.  (+info)

Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs. (6/1807)

BACKGROUND: It is unknown whether repeated dosages of vasopressin or epinephrine given early or late during basic life support cardiopulmonary resuscitation (CPR) may be able to increase coronary perfusion pressure above a threshold between 20 and 30 mm Hg that renders defibrillation successful. METHODS AND RESULTS: After 4 minutes of cardiac arrest, followed by 3 minutes of basic life support CPR, 12 animals were randomly assigned to receive, every 5 minutes, either vasopressin (early vasopressin: 0.4, 0.4, and 0.8 U/kg, respectively; n=6) or epinephrine (early epinephrine: 45, 45, and 200 microg/kg, respectively; n=6). Another 12 animals were randomly allocated after 4 minutes of cardiac arrest, followed by 8 minutes of basic life support CPR, to receive, every 5 minutes, either vasopressin (late vasopressin: 0.4 and 0.8 U/kg, respectively; n=6), or epinephrine (late epinephrine: 45 and 200 microg/kg, respectively; n=6). Defibrillation was attempted after 22 minutes of cardiac arrest. Mean+/-SEM coronary perfusion pressure was significantly higher 90 seconds after early vasopressin compared with early epinephrine (50+/-4 versus 34+/-3 mm Hg, P<0.02; 42+/-5 versus 15+/-3 mm Hg, P<0.0008; and 37+/-5 versus 11+/-3 mm Hg, P<0. 002, respectively). Mean+/-SEM coronary perfusion pressure was significantly higher 90 seconds after late vasopressin compared with late epinephrine (40+/-3 versus 22+/-4 mm Hg, P<0.004, and 32+/-4 versus 15+/-4 mm Hg, P<0.01, respectively). All vasopressin animals survived 60 minutes, whereas no epinephrine pig had return of spontaneous circulation (P<0.05). CONCLUSIONS: Repeated administration of vasopressin but only the first epinephrine dose given early and late during basic life support CPR maintained coronary perfusion pressure above the threshold that is needed for successful defibrillation.  (+info)

Separate receptors mediate oxytocin and vasopressin stimulation of cAMP in rat inner medullary collecting duct cells. (7/1807)

The two neurohypophysial hormones arginine vasopressin (AVP) and oxytocin have actions in the inner medullary collecting duct (IMCD) where both peptides induce an increase in cAMP accumulation. The present study has employed a novel IMCD cell line to determine whether these two hormones induce cAMP accumulation via common or separate receptors, and to characterize the potential receptors responsible. Equal volumes of vehicle (150 mM NaCl) or hormone/antagonist solutions were added to aliquots of 10(4) IMCD cells in the presence of 10(-3) M 3-isobutylmethylxanthine (IBMX) and incubated at 37 degrees C for 4 min. cAMP levels were determined by radioimmunoassay and protein concentration by Bradford assay. Both AVP and oxytocin elicited dose-dependent increases in cAMP generation, though oxytocin was less potent than AVP (EC50 = 1.6 x 10(-8) M vs. 7.4 x 10(-10) M). AVP at 10(-8) M and oxytocin at 10(-8) M, concentrations sufficient to elicit near-maximal cAMP accumulation, resulted in cAMP levels of 73.4 +/- 1.7 and 69.0 +/- 3.3 pmol (mg protein)-1 (4 min)-1, respectively (n = 10), compared with the vehicle-treated basal value of 37.7 +/- 2.2 pmol (mg protein)-1 (4 min)-1 (P < 0.001, n = 10). Combined AVP (10(-8) M) and oxytocin 10(-6) M) resulted in cAMP accumulation of 63.8 +/- 3.1 pmol (mg protein)-1 (4 min)-1 (n = 10), which was not significantly different from the effect of oxytocin alone, but slightly less than that for AVP alone (P < 0.05). A submaximal concentration of AVP (10(-10) M) induced cAMP accumulation of 48.6 +/- 2.5 pmol (mg protein)-1 (4 min)-1 (P < 0.01 compared with basal level of 34.9 +/- 2.4 pmol (mg protein)-1 (4 min)-1, n = 10), which was blocked in the presence of a vasopressin V2 receptor antagonist (10(-7) M OPC-31260) but not by the oxytocin receptor antagonist (10(-6) M [Pen1,pMePhe2, Thr4,Orn8]oxytocin) (36.3 +/- 6.1 and 45.1 +/- 1.3 pmol (mg protein)-1 (4 min)-1 respectively, P < 0.05, n = 10). A submaximal concentration of oxytocin (10(-7) M) induced a cAMP accumulation of 45.8 +/- 1.8 pmol (mg protein)-1 (4 min)-1 (n = 10), which was reduced by addition of 10(-6) M oxytocin antagonist (36.3 +/- 2.1 pmol (mg protein)-1 (4 min)-1, P < 0.05, n = 10), whereas co-incubation with 10(-6) M of the V2 receptor antagonist had no effect (43.2 +/- 1.3 pmol (mg protein)-1 (4 min)-1, n = 10). These results indicate that AVP and oxytocin induce cAMP accumulation from a common ATP pool in IMCD cells, and that separate vasopressin V2 and oxytocin receptor systems are involved, perhaps coupled to a common adenylate cyclase system.  (+info)

Mutant vasopressin precursors that cause autosomal dominant neurohypophyseal diabetes insipidus retain dimerization and impair the secretion of wild-type proteins. (8/1807)

Autosomal dominant familial neurohypophyseal diabetes insipidus is caused by mutations in the arginine vasopressin (AVP) gene. We demonstrated recently that mutant AVP precursors accumulate within the endoplasmic reticulum of neuronal cells, leading to cellular toxicity. In this study, the possibility that mutant AVP precursors interact with wild-type (WT) proteins to alter their processing and function was explored. WT and mutant precursors were epitope-tagged to allow them to be distinguished in transfected cells. An in vivo cross-linking reaction revealed homo- and heterodimer formation between WT and mutant precursors. Mutant precursors were also shown to impair intracellular trafficking of WT precursors from the endoplasmic reticulum to the Golgi apparatus. In addition to the cytotoxicity caused by mutant AVP precursors, the interaction between the WT and mutant precursors suggests that a dominant-negative mechanism may also contribute to the pathogenesis of familial neurohypophyseal diabetes insipidus.  (+info)

TY - JOUR. T1 - Effects of arginine vasopressin on hemodynamics and lung fluid balance in lambs. AU - Gest, A. L.. AU - Moise, A. A.. AU - Hansen, T. N.. AU - Kaplan, Sheldon. PY - 1989/1/1. Y1 - 1989/1/1. N2 - The purpose of this project was to study the effects of increased plasma concentrations of arginine vasopressin (AVP) on hemodynamics and lung fluid balance in lambs. We studied 16 unanesthetized newborn lambs during a base-line period and while infusing AVP into a hindlimb vein at 1.65 ± 0.12 and 2.98 ± 0.15 mU·kg-1·min-1. We measured aortic, pulmonary arterial, and left atrial pressures and heart rate continuously and cardiac output at frequent intervals. In five additional experiments, we collected samples of pure lung lymph during a base-line period and while infusing AVP at 2.02 ± 0.15 mU·kg-1·min-1. AVP infusion increased plasma concentrations of AVP to 11.3 ± 5.2 and 19.9 ± 5.2 μU/ml at the low and high rates of infusion, respectively. Both aortic and left atrial ...
TY - JOUR. T1 - Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model. AU - Wenzel, Volker. AU - Kern, Karl B. AU - Hilwig, Ronald W.. AU - Berg, Robert A.. AU - Schwarzacher, Severin. AU - Butman, Samuel M.. AU - Lindner, Karl H.. AU - Ewy, Gordon A.. PY - 2005/2. Y1 - 2005/2. N2 - Although arginine vasopressin (AVP) has been shown to be a promising drug during cardiopulmonary resuscitation (CPR), concern has been raised about the potential for AVP-mediated vasoconstriction of the coronary arteries. In a prospective, randomized laboratory investigation employing an established porcine model, the effects of AVP on haemodynamic variables, left anterior descending (LAD) coronary artery cross sectional area employing intravascular ultrasound (IVUS), and return of spontaneous circulation were studied. During sinus rhythm, the LAD coronary artery cross sectional area was measured by IVUS at baseline, and 90 s and 5 min after AVP ...
Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral oxygenation during shoulder surgery in the beach chair position: a prospective, single-blind study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Aim: To explore the association of plasma copeptin, the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon in obese men and men of normal weight. Methods: We measured fasting blood concentrations of copeptin and glucagon in 102 healthy obese men (mean ± sd age 49.4 ± 10.2 years) and a control group 27 healthy men of normal weight (mean ± sd age 51.5 ± 8.4 years). Differences between groups were evaluated using t-tests, and multiple linear regression analysis, adjusting for age and weight status (normal weight vs obese), was used to calculate unstandardized regression coefficients (β) with 95% CIs between copeptin and glucagon. Copeptin was (natural) log-transformed. Results: The obese men had higher [median (interquartile range)] plasma copeptin concentrations [6.6 (4.6-9.5) vs 4.9 (3.5-6.8) pmol/l; P = 0.040] and higher mean ± sd plasma glucagon concentrations (8.5 ± 3.8 vs 5.3 ± 1.4 pmol/l; P , 0.001) than the ...
Synonyms for arginine vasopressin hormone in Free Thesaurus. Antonyms for arginine vasopressin hormone. 3 synonyms for antidiuretic hormone: ADH, Pitressin, vasopressin. What are synonyms for arginine vasopressin hormone?
Animals were randomly allocated to four groups. In addition to a control group submitted to anaphylactic shock without any added therapy, three groups were designed according to the drug used for resuscitation: epinephrine (Aguettant, Lyon, France) only, AVP (Aguettant) only, and epinephrine followed by AVP (fig. 1). The investigator was not blinded to the drug used. The first bolus of epinephrine or AVP was injected 5 min after shock induction (T0 + 5 min). The second bolus of epinephrine was injected when the MAP began to decrease again after the initial increase following the first bolus. Doses of bolus were chosen according to our previous work.12 Two bolus of AVP followed by a continuous infusion induced the death of the animals due to multiple organs infarction (data not shown). Therefore, only one bolus of AVP was injected. To avoid any excessive volume loading, both drugs were prepared at different dilutions (in saline solution), and the syringes were changed when necessary to preserve a ...
The present study was undertaken to determine whether the non-peptide V2 arginine vasopressin (AVP) antagonist 5-dimethylamino- 1[4-(2-methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepi ne hydrochloride (OPC-31260) produces water diuresis and improves hyponatremia in patients with the syndr …
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A New Synthetic Route to YM087, an Arginine Vasopressin Antagonist.|span||/span| | Takashi Tsunoda; Akihiro Tanaka; Toshiyasu Mase; Shuichi Sakamoto | download | BookSC. Download books for free. Find books
Arginine Vasopressin (AVP, Antidiuretic Hormone, ADH),ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
Social behavior can be viewed as a varying output of an approach-avoidance conflict. For example a potential mate elicits a strong approach response and a predator induces the very opposite. Social behavior must be plastic to best adapt to a continuously changing (biotic and abiotic) environment. Different external states are mirrored by changes in levels of circulating sex hormones; presence of a mating opportunity elevates testosterone levels while presence of a stressor depresses it. I hypothesize that the plasticity in social behavior is a function of changes in circulating sex hormones; i.e. testosterone in males. Arginine vasopressin (AVP) is a neuropeptide widely implicated in social behavior. In the extrahypothalamic regions of the brain it is highly sensitive to testosterone. Castration causes a drop in AVP projections in the extrahypothalmic zone, medial amygdala (MEA); a change that can be attributed to an androgen dependent hypermethylation of the AVP promotor. For these reasons ...
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin Academic Article ...
The antidiuretic hormone arginine vasopressin (AVP) receptors are G protein-coupled receptors which consists of at least three types: V1A (vascular/hepatic) and V1B (anterior pituitary) receptors, which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+; and V2 (kidney) re...
We studied the involvement of periventricular and hypothalamic angiotensinergic and cholinergic pathways in osmotically induced arginine vasopressin (AVP) release into the blood. In conscious Wistar rats, i.c.v. injections of 0.2, 0.3 and 0.6 M hyperosmolar saline (5 μl) resulted in concentration-dependent increases in AVP release (5.2 ± 1.5, 10.6 ± 2.2 and 18.0 ± 2.2 pg/ml, respectively, vs. 2.0 ± 0.1 in controls). The two lower saline concentrations did not affect arterial blood pressure (non-pressure-associated AVP release), whereas 0.6 M saline induced increase in blood pressure (pressure-associated AVP release). In the first set of experiments, periventricular angiotensin AT1, muscarinic or nicotinic receptors were blocked by i.c.v. administration of losartan (10 nmol), atropine (100 nmol) or hexamethonium (100 nmol), respectively, before i.c.v. hyperosmolar saline injections. Losartan significantly reduced the 0.2 M and 0.3 M, but not the 0.6 M, saline-induced increase in AVP release. ...
3,4-methylenedioxymethamphetamine (MDMA) and its derivatives, 2,5-dimethoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine (PMA) are recreational drugs whose pharmacological effects have recently been attributed to serotonin 5HT2A/C receptors. However, there is growing evidence that the oxytocin/vasopressin system can modulate some the effects of MDMA. In this study, MDMA (2.5-10 mg/kg), DOB (0.5 mg/kg) or PMA (0.005, 0.1 or 0.25 mg/kg) were administered intramuscularly (IM) to adult zebrafish, alone or in combination with the V1a vasopressin antagonist, SR49059 (0.01-1 ng/kg), before carrying out conditioned place preference (CPP), social preference, novel tank diving and light-dark tests in order to evaluate subsequent rewarding, social and emotional-like behaviour. The combination of SR49059 and each drug progressively blocked: 1) rewarding behaviour as measured by CPP in terms of time spent in drug-paired compartment; 2) pro-social effects measured on the basis of the
It is well known that clonidine, which lowers blood pressure by acting as an alpha-2 agonist on inhibitory symnpathetic neurons in the CNS, lowers sympathetic outflow. It is also well known that patients with CHF have heightened sympathetic tone, as well as increased plasma levels of NEPI, AVP, PRA, and other vasoactive hormones. This group treated 20 patients with Class IV NYHA heart failure with clonidine (0.15 mg BID) and compared hemodynamic measurements (obtained by right heart catheterization) before therapy as well as 2-3 hours and 7 days later. They found that clonidine not only lowered MAP, but also right atrial, mean pulmonary artery, and wedge pressures. Cardiac output was unchanged, but stroke volume index increased substantially, suggesting a possible improvement in LV compliance. The changes at 2-3 hours appeared to be sustained over 7 days. Plasma NEPI levels were markedly reduced (by 62% after 1 week), but plasma AVP levels increased. On the basis of these findings the authors ...
Vasopressin is a potent peripheral vasoconstrictor. Vasopressin has a direct action on the kidney. It also constricts peripheral vessels and causes contraction of the smooth muscle of the intestine, gall bladder and urinary bladder.. Due to rapid inactivation by a number of enzymes that cleave the peptide at several sites, the effects of vasopressin are relatively short lived unless given by continuous infusions. ...
A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21) . ...
A non-peptide, kappa-opioid receptor agonist which has also been found to stimulate the release of adrenocorticotropin (ADRENOCORTICOTROPIC HORMONE) via the release of hypothalamic arginine vasopressin (ARGININE VASOPRESSIN) and CORTICOTROPIN-RELEASING HORMONE. (From J Pharmacol Exp Ther 1997;280(1):416-21) . ...
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Participant has successfully completed Studies 15-AVP-786-301, 15-AVP-786-302, 12-AVR-131, or 17-AVP-786-305.. Participants will be enrolled in the study for approximately 56 weeks (participants who have a follow-up visit 3 months after the last dose of treatment will be enrolled for approximately 64 weeks).. Approximately 1000 participants will be enrolled at approximately 250 centers globally.. All participants enrolled will receive AVP-786; the treatment dose assigned will be masked to the participant, investigator, study staff, and the sponsor.. ...
Participant has successfully completed Studies 15-AVP-786-301, 15-AVP-786-302, 12-AVR-131, or 17-AVP-786-305.. Participants will be enrolled in the study for approximately 56 weeks (participants who have a follow-up visit 3 months after the last dose of treatment will be enrolled for approximately 64 weeks).. Approximately 1000 participants will be enrolled at approximately 250 centers globally.. All participants enrolled will receive AVP-786; the treatment dose assigned will be masked to the participant, investigator, study staff, and the sponsor. ...
ANSWER: Bed-wetters are not willfully wetting the bed, so they should never be punished or humiliated. At age 5, about 7 percent of boys still wet the bed. By age 10, that number decreases to 3 percent, and by age 18, only 1 percent have the problem. A smaller number of girls wet the bed. For some, its a family trait. A bladder slightly smaller than it should be for the childs age is another factor. Slowness in maturation of the nerve connections of the bladder is a possible cause. And some children secrete too little of the hormone (antidiuretic hormone, also called arginine vasopressin) that slows the production of urine during the night. Children who are in the deep stages of sleep might not respond to signals that the bladder is full ...
RESULTS: Surgery resulted in decreased ex vivo mHLA-DR expression, but no change in IL-10 or IL-12 plasma levels. mHLA-DR was low in LPS culture over the 4 postoperative days, whereas IL-10 release was increased and not counterbalanced by IL-12p40 production. The hormonal plasma pattern showed increased prolactin during anesthesia and peaks of cortisol, ACTH and arginine vasopressin during waking, but no alteration in catecholamine levels. mHLA-DR expression in LPS culture was not modified by plasma replacement, except immediately after surgery ...
Arginine HCL 400g, ALLMAX Nutrition Precursor for synthesis of Nitric Oxide (NO)* Promotes muscle mass* Arginine is considered a semi-essential amino acid. What that means is the body produces Arginine normally, but sometimes the body needs more than is available and Arginine needs to be supplemented. Food sources suc
Aspire - Tekno AVP Replacement Pod 2ml. Aspire Tekno AVP empty replacement pods have a refillable capacity of 2ml. These pods are specifically designed to be used with the Aspire Tekno Pod Vape Kit.
Heres my AvP Requiem Blu-Ray Review. The film isnt a total loss, there are some genuinely good moments but the script is just awful.
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BACKGROUND: Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder. In golden hamsters, arginine vasopressin microinjections into the anterior hypothalamus trigger robust grooming and flank marking, a stereotyped scent marking behaviors. The intensity and repetition of the behaviors induced by arginine vasopressin is somewhat reminiscent of Obsessive Compulsive Disorder in humans. The present experiments were carried out to test whether pharmacological agents used to alleviate obsessive compulsive disorder could inhibit arginine vasopressin-induced flank marking and grooming. RESULTS: Male golden hamsters were treated daily for two weeks with either vehicle, fluoxetine, clomipramine, or desipramine (an ineffective drug), before being tested for arginine vasopressin-induced flank marking and grooming. Flank marking was significantly inhibited in animals treated with fluoxetine or clomipramine
U.S., Jan. 12 -- registry received information related to the study (NCT03014063) titled Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock on Jan. 4. Brief Summary: This is a prospective observational cohort trial evaluating a single plasma vasopressin concentration in patients receiving exogenous, adjunctive vasopressin for septic shock. The trial is designed to determine whether plasma vasopressin concentration influences the likelihood of hemodynamic response to exogenous vasopressin therapy. Study Start Date: November 2016 Study Type: Observational Condition: Septic Shock Intervention: Not Provided Recruitment Status: Recruiting Sponsor: The Cleveland Clinic Information provided by (Responsible Party): The Cleveland Clinic ...
TY - JOUR. T1 - The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis. AU - Maybauer, Marc O.. AU - Maybauer, Dirk M.. AU - Enkhbaatar, Perenlei. AU - Laporte, Régent. AU - Winiewska, Halina. AU - Traber, Lillian D.. AU - Lin, Chiidean. AU - Fan, Juanjuan. AU - Hawkins, Hal K.. AU - Cox, Robert A.. AU - Winiewski, Kazimierz. AU - Schteingart, Claudio D.. AU - Landry, Donald W.. AU - Rivière, Pierre J M. AU - Traber, Daniel L.. PY - 2014. Y1 - 2014. N2 - OBJECTIVE:: To determine if the selective vasopressin type 1a receptor agonist selepressin (FE 202158) is as effective as the mixed vasopressin type 1a receptor/vasopressin V2 receptor agonist vasopressor hormone arginine vasopressin when used as a titrated first-line vasopressor therapy in an ovine model of Pseudomonas aeruginosa pneumonia-induced severe sepsis. DESIGN:: Prospective, randomized, controlled laboratory experiment. SETTING:: University animal research facility. ...
OBJECTIVE: To investigate the involvement of serotonin (5-hydroxytryptamine - 5-HT) receptors in mediation of stress-induced arginine vasopressin (AVP) and oxytocin (OT) secretion in male rats.. DESIGN: Experiments on laboratory rats with control groups.. METHODS: Different stress paradigms were applied after pretreatment with intracerebroventricular infusion of saline or different 5-HT antagonists.. RESULTS: Restraint stress (5 min), hypotensive hemorrhage or dehydration for 24 h increased AVP secretion fivefold and OT secretion threefold. Swim stress for 3 min had no effect on AVP secretion, but increased OT secretion threefold. Ether vapor or hypoglycemia had no effect on AVP or OT secretion. The restraint stress-induced AVP response was inhibited by pretreatment with the 5-HT(2A+2C) antagonists ketanserin (KET) and LY-53857 (LY) and the 5-HT(3+4) antagonist ICS-205930 (ICS), whereas the 5-HT(1A) antagonist WAY-100635 (WAY) had no effect. The OT response to restraint stress was inhibited by ...
Axon terminals in the posterior pituitary store large quantities of the hormone vasopressin (AVP), buffering the synthesizing neurons in the hypothalamus against acute changes in physiological demand for hormone release. The dynamics of pituitary AVP content reflect the competing processes of release and synthesis. This report demonstrates substantial increases in pituitary AVP content in the maturing rat. Between 7-10 weeks of age, the total pituitary AVP content in the rat increases from 957 +/- 72 to 1667 +/- 160 ng. Cross-sectional data indicate a parallel relationship between body weight and pituitary AVP content. Nevertheless, weight maintenance does not affect age-related increases in AVP content. Decreasing demand for hormone release and synthesis by inducing hyponatremia blocks subsequent pituitary accumulation. After withdrawing the hyponatremic experimental conditions, animals resume accumulation of pituitary AVP, but do not catch up to age-matched controls. This indicates that increases in
TY - JOUR. T1 - Taurine modulates arginine vasopressin-mediated regulation of renal function. AU - Mozaffari, Mahmood S.. AU - Schaffer, David. PY - 2001/6/7. Y1 - 2001/6/7. N2 - Taurine has been implicated in the regulation of arginine vasopressin (AVP) secretion, and we have previously shown altered renal excretory function in the taurine-depleted rat. To further elucidate the role of taurine in AVP-mediated renal responses, the effects of an antagonist for renal AVP receptors were examined in four groups of conscious rats: control, taurine-supplemented, taurine-depleted, and taurine-repleted. Control and taurine-supplemented rats displayed similar and significant AVP receptor antagonist-induced elevations in fluid excretion, sodium excretion, and free water clearance but a marked reduction in urine osmolality. These effects are consistent with inhibition of endogenous AVP activity. By contrast, in the taurine-depleted rats, the magnitude and the time course of drug-induced renal excretory ...
Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor antagonists from desloratadine via successive acylation, reduction and acylation reactions. Their structures were characterized by 1H-NMR and HRMS, their biological activity was evaluated by in vitro and in vivo studies. The in vitro binding assay and cAMP accumulation assay indicated that these compounds are potent selective V2 receptor antagonists. Among them compounds 1n, 1t and 1v exhibited both high affinity and promising selectivity for V2 receptors. The in vivo diuretic assay demonstrated that 1t presented remarkable diuretic activity. In conclusion, 1t is a potent novel AVP V2 receptor antagonist candidate.
Rivalland, Elizabeth T.A., Iqbal, J., Clarke, I.J., Turner, Anne I. and Tilbrook, A.J. 2003, Distribution and co-localisation of corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP) and enkephalin (Enk) in the paraventricular nucleus (PVN) of the ewe, in Proceedings of the Endocrine Society of Australia, Endocrine Society of Australia, Melbourne, Vic., pp. 305-305. ...
Vasopressin-sensitive aquaporin-2 (Aqp2) in the apical membrane of the renal collecting duct (Fenton et al., 2008). Controls cell volume and thereby influences cell proliferation (Di Giusto et al. 2012). It plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane. This process is tightly controlled by the pituitary hormone arginine vasopressin, and defective trafficking results in nephrogenic diabetes insipidus (NDI). The crystal structure of Aqp2 has been solved to 2.75Å (Frick et al. 2014). In terrestrial vertebrates, AQP2 function is generally regulated by arginine-vasopressin to accomplish key functions in osmoregulation such as the maintenance of body water homeostasis by a cyclic AMP-independent mechanism (Olesen and Fenton 2017; Martos-Sitcha et al. 2015 ...
Increasing amounts of data suggest that affective disorders might be related to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, one of the stress-response systems. Arginine vasopressin (AVP) influences several symptoms, relevant to affective disorders, notable memory processes, pain sensitivity, synchronization of biological rhythms and the timing and quality of REM sleep. We examined whether genetic variations in the AVP receptor 1b gene (AVPR1b) could be associated with increased susceptibility to affective disorders using a gene-based association analysis of single-nucleotide polymorphisms (SNPs). Five SNPs were identified in AVPR1b and genotyped in two well-diagnosed samples of patients with recurrent major depression and matched controls. In the Swedish sample, we observed significant allele (P=0.02) and genotype (P=0.01) association with SNP AVPR1b-s3, and in the Belgian sample, a borderline significant association with SNP AVPR1b-s5 (P=0.04). In both patient-control ...
In this study we found that, in 31 normal subjects, close to 90% of circulating arginine vasopressin (AVP), measured by radioimmunoassay, was associated with platelets. By using routine methods of centrifugation, which do not completely separate platelets, the normal range of plasma vasopressin was higher by twofold than the normal range in platelet-free plasma prepared by differential centrifugation, which was 1.4 +/- 1.0 sd pg/ml. Platelet vasopressin was 12.9 +/- 5.7 pg/ml. Patients with congestive heart failure had, on average, an elevated platelet-free plasma AVP, as did two patients with thrombocytopenia and one with thrombocytosis. Patients with essential hypertension had slightly high levels of platelet-free plasma AVP and demonstrated an abnormal inverse relationship between platelet-free plasma AVP and serum osmolality. Immunoreactive platelet vasopressin was slightly low in patients with essential hypertension and was subnormal in patients with congestive heart failure. These studies ...
A novel finding of this study was that an elevated BUN level at discharge significantly modified the relationship between eGFR at discharge and the higher risk of all-cause or cardiac death after discharge, suggesting that the association between eGFR and outcomes may be largely dependent on the presence of an elevated BUN level. The mechanism underlying this association is unclear, but some assumptions can be made. It is well known that creatinine is freely filtered by the glomerulus and not reabsorbed and that it undergoes tubular secretion. In contrast, urea is freely filtered and not secreted but is reabsorbed by the renal tubules (11). Accordingly, BUN is influenced by enhanced proximal and distal tubular reabsorption caused by neurohormonal activation, the urine flow rate, and the effect of arginine vasopressin on the urea transporter in the collecting duct (1,11,26). Thus, elevation of BUN may serve as an index of neurohormonal activation over and above any decline of eGFR (11). ...
Ever wonder what attracts you to your significant other and gives you a special bond with them? A study done on monogamous voles may have surprising ties with humans. The study ( has found that two chemicals found in voles (and in humans) Oxytocin (OT) and Arginine Vasopressin (AV), have found to be very important in pair bonding. The chemical Oxytocin has been shown to be very important in both males and females however more so to females then males. Males on the other hand, seem to be more effected by Arginine Vasopressin which leads them to be more aggressive, mark their territory and courtship. This is interesting because both sexes show the same number of receptors for both Oxytocin and Arginine Vasopressin. The study has been able to conclude that when Oxytocin is present in both sexes, pair bonding is increased even without mating. If Oxytocin is blocked for any reason pair bonding is prevented and the animals do not show signs of ...
The effect of lowering the pressure of oxygen from 80 to 34 mm Hg was examined in anesthetized dogs that were undergoing a water diuresis. This degree of hypoxia was associated with an antidiuresis as urine osmolality (Uosm) increased from 107 to 316 mosmol/kg H2O (P < 0.001) and plasma arginine vasopressin increased from 0.06 to 7.5 μU/ml, (P < 0.05). However, hypoxia was not associated with significant changes in cardiac output (CO, from 4.2 to 4.7 liters/ min), mean arterial pressure (MAP, from 143 to 149 mm Hg), glomerular filtration rate (GFR, from 46 to 42 ml/min), solute excretion rate (SV, from 302 to 297 mosmol/min), or filtration fraction (from 0.26 to 0.27, NS). Hypoxia was associated with an increase in renal vascular resistance (from 0.49 to 0.58 mm Hg/ml per min, P < 0.01). The magnitude of hypoxia-induced antidiuresis was the same in innervated kidneys and denervated kidneys. To further examine the role of vasopressin in this antidiuresis, hypoxia was induced in hypophysectomized ...
Oxytocin (OT) and vasopressin (AVP) play a major role in social behaviours. Mice have become the species of choice for neurobiology of social behaviour due to identification of mouse pheromones and the advantage of genetically modified mice. However, neuroanatomical data on nonapeptidergic systems in mice are fragmentary, especially concerning the central distribution of OT. Therefore, we analyse the immunoreactivity for OT and its neurophysin in the brain of male and female mice (strain CD1). Further, we combine immunofluorescent detection of OT and AVP to locate cells co-expressing both peptides and their putative axonal processes. The results indicate that OT is present in cells of the neurosecretory paraventricular (Pa) and supraoptic hypothalamic nuclei (SON). From the anterior SON, OTergic cells extend into the medial amygdala, where a sparse cell population occupies its ventral anterior and posterior divisions. Co-expression of OT and AVP in these nuclei is rare. Moreover, a remarkable ...
The major findings of this study were that in the perfused rat CCD, the selective alpha-2 agonist dexmedetomidine reduced (1) AVP-stimulated Pf by 95% to 100%, (2) AVP-stimulated Pf in the presence of the PKC inhibitor staurosporine by 70% to 75% and (3) 8CPT-cAMP-stimulated Pf by 25% to 35%. Dexmedetomidine significantly reversed the AVP-induced effects on Vt and Rt. Overall, these findings indicate analpha-2-mediated mechanism that modulates AVP-dependent Na+ and water transport in the rat CCD, and the mechanism appears to include post-cAMP events in addition to the pre-cAMP event of alpha-2-induced inhibition of adenylyl cyclase.. Although the precise physiological function of renal alpha-2 adrenoceptors is not yet defined, it is well known thatalpha-2 agonists enhance urine output. Blandford and Smyth (1988, 1989) and Smyth et al. (1992) demonstrated that this effect is mediated in at least two separate sites in the kidney: one is non-AVP dependent, in which urine output is secondary to ...
Chelko SP, Schmiedt CW, Lewis TH, et al. Vasopressin-induced constriction of the isolated rat occipital artery is segment dependent. J Vasc Res. 2013;50(6):478-85. PMID: 24192548.. Mastropaolo M, Zizzo MG, Auteri M, et al. Arginine vasopressin, via activation of post-junctional V1 receptors, induces contractile effects in mouse distal colon. Regul Pept. 2013 Nov 10;187:29-34. PMID: 24185041.. Salazar M, Hu BB, Vazquez J, et al. Exogenous Vasopressin-Induced Hyponatremia in Patients With Vasodilatory Shock: Two Case Reports and Literature Review. J Intensive Care Med. 2013 Oct 7. [Epub ahead of print]. PMID: 24106070. ...
TY - JOUR. T1 - Neurohumoral and cardiopulmonary response to sustained submaximal exercise in the dog. AU - Kirlin, P. C.. AU - Kittleson, Mark D. AU - Johnson, L. E.. PY - 1987. Y1 - 1987. N2 - Neurohumoral, cardiovascular, and respiratory parameters were evaluated during sustained submaximal exercise (3.2 km/h, 15° elevation) in normal adult mongrel dogs. At the level of activity achieved (fivefold elevation of total body O2 consumption and threefold elevation of cardiac output), significant (P , 0.05) increases in plasma norepinephrine and epinephrine concentration (from 150 ± 23 to 341 ± 35 and from 127 ± 27 to 222 ± 31 pg/ml, respectively) were present, as well as smaller but significant increases in plasma renin activity and plasma aldosterone concentration (from 2.2 ± 0.3 to 3.1 ± 0.6 ng·ml-1·h-1 and from 98 ± 8 to 130 ± 6 pg/ml, respectively). Plasma arginine vasopressin increased variably and insignificantly. The cardiovascular response (heart rate, systemic arterial and ...
Argipressin binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin is a selective V2 agonist. - Mechanism of Action & Protocol.
Vasopressin is a man-made form of a hormone called anti-diuretic hormone that is normally secreted by the pituitary gland. Vasopressin acts on the kidneys and blood vessels. Vasopressin helps prevent loss of water from the body by reducing urine output and helping the kidneys reabsorb water into the body. Vasopressin...
Definition of vasopressins in the dictionary. Meaning of vasopressins. What does vasopressins mean? Information and translations of vasopressins in the most comprehensive dictionary definitions resource on the web.
Vasopressin (also, anti-diuretic hormone (ADH) or arginine vasopressin (AVP)) has been shown to be a very effective vasopressor, especially in circumstances…
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Vasopressin in cardiac surgery. There is limited evidence surrounding the use of vasopressin in cardiac surgery. Anecdotally, we use vasopressin, both during cardiopulmonary bypass and after, when patients have refractory shock. We have no idea what impact this intervention has on outcome. One small (unconvincing) study suggests that the addition of vasopressin is not associated with increased predicted mortality associated with cardiac surgery.27 Specifically, and with scant evidence, vasopressin has been advocated for refractory shock in this setting, especially when there is coexisting pulmonary hypertension.28 In early animal studies, vasopressin was shown to cause pulmonary vasodilation. However, in a well-conducted dog study, vasopressin was shown to cause pulmonary vascular constriction and to exert an important negative inotropic effect on the right ventricle.29 This was not the case when phenylephrine was used to augment systemic BP.29 It may be that at high doses vasopressin causes ...
Current HF therapy improves outcomes but may be underutilized. Novel cardiovascular and/or anabolic hormones may emerge as targets for therapy. Specifically, women with CRT may have especially good prognosis; HTx and LVAD are underutilized and screening may increase the number of patients who may benefit from these treatments; ghrelin and arginine vasopressin may be involved in the pathophysiology of HF and emerge as potential novel targets; and the cardiovascular hormones BNP, ANP and ADM can characterize differences between and provide targets for potential therapy in different HF phenotypes ...
Severn Biotech, Limited SBP0296 - [Arg8]-Vasopressin - SBP0296 - [Arg8]-Vasopressin AVP MW: 1084.4 H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Cys1-6, cyclic) Bell, J. et al. (1992) Int. J. Immunopharm. 14, 92. 5mg 25mg
AVPR1B antibody (arginine vasopressin receptor 1B) for IHC-P. Anti-AVPR1B pAb (GTX78015) is tested in Human samples. 100% Ab-Assurance.
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PMID 25016245] Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers executive functioning ...
Physiological admeasurement for diagnosing psychiatric disorders. Based on several beastly studies, NMDA receptor - amenable for mediating fast synaptic manual in the axial afraid arrangement (CNS) - can aswell adapt the absolution of arginine vasopressin (AVP) in the bloodstream. By aesthetic AVP absolution in bodies with a alkali solution, it was noticed that the allegation were constant with the above-mentioned beastly studies, i.e., participants challenged by abasement apparent an access in AVP and others grappling with schizophrenia displayed a abatement in AVP.. As of now, the in vivo appraisal of the NMDA receptors in bodies is not a possibility; therefore, the allegation of the abstraction are of abundant value, such that it uses the different blood-based biomarker to appraise the two brainy disorders. The analysis of this access has the abeyant to appraise any basal vulnerabilities of the patients harboring depressive affection or schizophrenia during psychiatric screening. In practice, ...
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Tan, H.; Chen, L.; Li, X.; Li, M.; Zhao, M.: A target-driven DNA-based molecular machine for rapid and homogeneous detection of arginine-vasopressin. Analyst 145 (3), pp. 880 - 886 (2020 ...
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Vasopressin also called Argipressin (8-L-Arginine Vasopressin) has a molecular weight of 1084.23 Dalton and a molecular formula of C46H65N15O12S2.
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The thing about science is that its always evolving. As we learn more about how the human body works, the things we always held as true may change. Recently, in the media, there have been some claims that cholesterol might not be as bad for you as originally thought. Many are taking this to mean […]. ...

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Arginine Vasopressin Antagonists. Class Summary. These agents treat hyponatremia through V2 antagonism of AVP in the renal ... Arginine vasopressin antagonist (V1A, V2) indicated for euvolemic (dilutional) and hypervolemic hyponatremia. Increases urine ... Vasopressin-receptor antagonists: a new class of agents for the treatment of hyponatremia. Endocr Metab Immune Disord Drug ... Selective vasopressin V2 -receptor antagonist. Indicated for hypervolemic and euvolemic hyponatremia (ie, serum sodium level , ...
Vasopressin Analog. Desmopressin. Desmopressin (DDAVP), synthetic analogue of the antidiuretic hormone arginine vasopressin, ... Arginine Vasopressin Antagonists. Class Summary. V2 receptor antagonism of AVP in the renal collecting duct results in ... This is followed by use of loop diuretics (eg, furosemide), arginine vasopressin (AVP) receptor antagonists (eg, tolvaptan), [ ... Arginine vasopressin antagonist (V1A, V2), indicated for euvolemic (dilutional) and hypervolemic hyponatremia, increases urine ...
Arginine vasopressin derivatives. Class Summary. Indicated in patients with thromboembolic disorders.. Desmopressin (DDAVP). * ...
Atrial Peptide will Inhibit Osmolality Induced Release of Arginine Vasopressin in Man M.J. Allen; M.J. Allen ... M.J. Allen, V. Ang, E.D. Bennett, J.S. Jenkins; Atrial Peptide will Inhibit Osmolality Induced Release of Arginine Vasopressin ...
Arginine vasopressin (AVP) is a neurohypophysial hormone found in most mammals, including humans. It is invlolved in regulating ... Antogonists of Vasopressin V1B Receptor (AVPR1B) has been found to protect against depression. It has also been theorized that ...
1-Desamino 8D Arginine Vasopressin (DDAVP) ELISA Kit, Cat#EKU02012. Write a Review Write a Review. × ... 1-Desamino 8D Arginine Vasopressin (DDAVP) ELISA Kit, Cat#EKU02012. Rating Required Select Rating. 1 star (worst). 2 stars. 3 ... This assay has high sensitivity and excellent specificity for detection of 1-Desamino 8D Arginine Vasopressin (DDAVP). No ... significant cross-reactivity or interference between 1-Desamino 8D Arginine Vasopressin (DDAVP) and analogues was observed. ...
Arginine vasopressin (AVP) which exerts diverse biological effects in mammals is no more restricted to the posterior pituitary ... Arginine vasopressin as a neurotransmitter in brain. Indian Journal of Experimental Biology. 1998 Jul; 36(7): 635-43. ... Added to this is the recently available specific vasopressin receptor antagonists. At present AVP seems to be involved in ... With the characterization of three different types of vasopressin receptor subtypes V1a, V1b and V2 responsible for its actions ...
Vasopressin Analog. Desmopressin. Desmopressin (DDAVP), synthetic analogue of the antidiuretic hormone arginine vasopressin, ... Arginine Vasopressin Antagonists. Class Summary. V2 receptor antagonism of AVP in the renal collecting duct results in ... This is followed by use of loop diuretics (eg, furosemide), arginine vasopressin (AVP) receptor antagonists (eg, tolvaptan), [ ... Arginine vasopressin antagonist (V1A, V2), indicated for euvolemic (dilutional) and hypervolemic hyponatremia, increases urine ...
AVP: arginine vasopressin. *AVPR2: arginine vasopressin receptor 2. *About MedlinePlus. *Whats New ...
Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes ... Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes ...
Vasopressins / blood* * Water Intoxication / blood* * Water Intoxication / diagnosis Substances * Vasopressins * Arginine ... Psychotic exacerbations and enhanced vasopressin secretion in schizophrenic patients with hyponatremia and polydipsia Arch Gen ...
Kahn RS, Kling MA, Wetzler S, Asnis GM, van Praag H. Effect of m-chlorophenylpiperazine on plasma arginine-vasopressin ... keywords = "Arginine-vasopressin, Human, Serotonin, m-Chlorophenylpiperazine",. author = "Kahn, {Ren{\e} S.} and Kling, { ... Effect of m-chlorophenylpiperazine on plasma arginine-vasopressin concentrations in healthy subjects. / Kahn, René S.; Kling, ... Effect of m-chlorophenylpiperazine on plasma arginine-vasopressin concentrations in healthy subjects. In: Psychopharmacology. ...
Arginine Vasopressin, Neuropeptide Y, MAO, CREB, and Corticotropin-Releasing Factor*Introduction. *Nicotine-Induced ...
Absorption, Arginine Vasopressin, Deamino Arginine Vasopressin, Glucocorticoids, Kidney, Osmolar Concentration, Thirst. Source: ... Arginine vasopressin-dependent and AVP-independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid ... Arginine vasopressin-dependent and AVP-independent mechanisms of renal fluid absorption during thirsting despite glucocorticoid ... OBJECTIVE: Glucocorticoids seem to modify the release and effects of plasma arginine vasopressin (pAVP). However, underlying ...
Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we ... Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we ... Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we ... Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we ...
Arginine Vasopressin. Corticotropin. Adrenocorticotropic Hormone. Enteroglucagons. Glucagon-Like Peptides. Glucagon Precursors ...
arginine vasopressin. ISO. CTD Direct Evidence: marker/mechanism. CTD. PMID:2832203. NCBI chr 3:117,793,447...117,805,091 ...
Previous Missing link in anaemia: arginine vasopressin. * Next Different alcoholic drinks bring out different emotions ...
Arginine Vasopressin Neurons The Arginine Vasopressin neurons (AVP) neurons are located in the supraoptic nucleus. They project ... Many of the SCN neurons are GABAergic, and many express arginin-vasopressin (AVP) or vasointestinal polypeptide (VIP). These ... However, for others, typically those with slower cycle times (e.g. vasopressin neurons), pulsatility is mediated by a general ... Roper P., Callaway J., Armstrong W. (2004). Burst initiation and termination in phasic vasopressin cells of the rat supraoptic ...
Abbreviations: AQP, aquaporin; AVP, arginine vasopressin.. *View Large Image *Figure Viewer. *Download Hi-res image ... However, creation of maximally concentrated urine depends on more than just the presence of vasopressin. Vasopressin achieves ... Vasopressins action on the V1 receptors on the smooth muscles of the vasculature give this hormone its original name, but its ... When vasopressin activates the V2 receptors on the basolateral aspect of the collecting duct cells in the kidney, an ...
The change in structure of arginine vasopressin to desmopressin acetate resulted in increased duration of action and a ... 1-(3-mercaptopropionic acid)-8-D-arginine vasopressin monoacetate (salt).. Desmopressin acetate solution for injection is a ... Desmopressin Acetate Injection is a vasopressin analog used for: *Central Diabetes Insipidus - as antidiuretic replacement ... Desmopressin Acetate Injection, USP is a synthetic vasopressin analog for intravenous or subcutaneous use. It is chemically ...
All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the ...
Vasopressin. Arginine vasopressin, Antidiuretic hormone, Argipressin. AVP, ADH. parvocellular neuroendocrine neurons in the ... with vasopressin, stimulates secretion of ACTH Dopamine. Prolactin-inhibiting hormone. DA, PIH. neuroendocrine neurons of the ...
LOINC Code 100815-0 Vasopressin [Moles/volume] in Plasma --12th specimen post XXX challenge ... 100815-0Vasopressin [Moles/volume] in Plasma --12th specimen post XXX challengeActive. Part Description. LP15949-8 Vasopressin ... Vasopressin sp12 p chal Plas-sCnc. Display Name. Vasopressin 12th specimen post Unsp challenge (P) [Moles/Vol]. Consumer Name ... Vasopressin^12th specimen post XXX challenge. Property. SCnc. Time. Pt. System. Plas. Scale. Qn. Method. Additional Names. ...
Arginine Vasopressin 13% * Pentobarbital 11% * Peptidyl-Dipeptidase A 11% * Inferior Vena Cava 11% ...
Studies of radioimmunoassay of Arginine Vasopressin (AVP). T. SAITO, S. YOSHIDA, T. MURASE, K. NAKAO. The Third Department of ...
... and arginine vasopressin receptor 1A [AVPR1A]), although the fold change for AVPR1A was low (Fig. 4). The only differentially ... Vasopressin (homologous to avian vasotocin) is strongly associated with aggression during periods of parental care in mammals [ ... Vasopressin released within the central amygdala promotes maternal aggression. Eur J Neurosci. 2010;31:883-91. ... Social functions of individual vasopressin-oxytocin cell groups in vertebrates: what do we really know? Front Neuroendocrinol. ...
AVP arginine vasopressin [KO:K05242]. Organism. hsa_var Human gene variants (Homo sapiens). ...
  • Desmopressin (DDAVP), synthetic analogue of the antidiuretic hormone arginine vasopressin, increases cyclic adenosine monophosphate (cAMP), in a dose dependent manner, in renal tubular cells which increases water permeability resulting in decreased urine volume and increased urine osmolality. (
  • This assay has high sensitivity and excellent specificity for detection of 1-Desamino 8D Arginine Vasopressin (DDAVP). (
  • No significant cross-reactivity or interference between 1-Desamino 8D Arginine Vasopressin (DDAVP) and analogues was observed. (
  • One specific analog of arginine vasopressin, 1-desamine-8-D-arginine vasopressin (DDAVP), has been shown to improve learning and memory in humans. (
  • Added to this is the recently available specific vasopressin receptor antagonists. (
  • To assess the involvement of arginine vasopressin (AVP) in genetical diabetic (db/db) mice, we examined the mRNA expression levels of AVP and vasopressin V 1a receptors (V 1a R) in brain and liver of db/db mice. (
  • Because cAMP is a central modulator of arginine vasopressin (AVP)-induced water transport in the renal collecting duct (CD), we hypothesized that if expressed in the CD, P2Y 12 -R may play a role in renal handling of water in health and in nephrogenic diabetes insipidus.We found P2Y 12 -R mRNA expression in rat kidney, and immunolocalized its protein and aquaporin-2 (AQP2) in CD principal cells. (
  • Vasopressin, a vasoconstrictor, acts on the kidney collecting ducts to increase water reabsorption, increase blood volume and blood pressure. (
  • Association of copeptin, a surrogate marker of arginine vasopressin, with decreased kidney function in sugarcane workers in Guatemala. (
  • Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin being observed in Central America. (
  • The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. (
  • Gender Differences in Nighttime Plasma Arginine Vasopressin and Delayed Compensatory Urine Output in the Elderly Population After Desmopressin. (
  • Arginine vasopressin (AVP) is a neurohypophysial hormone found in most mammals, including humans. (
  • The urgent need to urinate after drinking alcohol begins with a small and effective hormone with many names: vasopressin, arginine vasopressin, or antidiuretic hormone, or ADH for short. (
  • For this reason, other dynamic tests have been proposed such as arginine (ARG), combined GH releasing hormone plus ARG (GHRH-ARG), levodopa (L-DOPA) in spite of data indicating poor performance of some of these tests for evaluation of adult GHD. (
  • methylphenidate transdermal and vasopressin both increase sympathetic (adrenergic) effects, including increased blood pressure and heart rate. (
  • The posterior pituitary is innervated by the terminals of oxytocin and vasopressin neurons which originate in the hypothalamus and which synapse directly on capillaries that fenestrate the pituitary. (
  • However, for others, typically those with slower cycle times (e.g. vasopressin neurons), pulsatility is mediated by a general increase in firing rate across the population, but there is little or no synchronization of individual firing times. (
  • 10 Jackson E K. Vasopressin and other agents affecting the renal conservation of water. (
  • OBJECTIVE: To assess renal injury in an arginine vasopressin (AVP) rodent model of preeclampsia. (
  • 2 , - 4 To our knowledge, we are the first to report the successful treatment of anaphylactic shock with terlipressin, a structural analog of arginine vasopressin. (
  • Moreover, our work revealed ELS-induced hypomethylation of the arginine vasopressin (Avp) gene enhancer and pro-opiomelanocortin (Pomc) promoter. (
  • Association of arginine vasopressin (AVP) promoter polymorphisms with preeclampsia. (
  • Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition. (
  • Arginine vasopressin 1a receptor RS3 promoter microsatellites in schizophrenia: a study of the effect of the 'risk' allele on clinical symptoms and facial affect recognition. (
  • Arginine vasopressin antagonist (V 1A , V 2 ) indicated for euvolemic (dilutional) and hypervolemic hyponatremia. (
  • Arginine vasopressin antagonist (V1A, V2), indicated for euvolemic (dilutional) and hypervolemic hyponatremia, increases urine output of mostly free water, with little electrolyte loss. (
  • Selective vasopressin V2-receptor antagonist is indicated for euvolemic or hypervolemic hyponatremia, associated with SIADH or congestive heart failure. (
  • Selective vasopressin V 2 -receptor antagonist. (
  • OBJECTIVE: Glucocorticoids seem to modify the release and effects of plasma arginine vasopressin (pAVP). (
  • 30. Nagai N, Nagai K, Chun SJ, Shimizu K, Takezawa K, Tsuji K, Sugahara K, Nakagawa H. Roles of the suprachiasmatic nucleus and vasoactive intestinal peptide in the response of plasma arginine vasopressin to osmotic challenge. (
  • Arginine vasopressin (AVP) which exerts diverse biological effects in mammals is no more restricted to the posterior pituitary. (
  • All mammals have arginine vasopressin except the pig with a lysine at position 8. (
  • demeclocycline decreases effects of vasopressin by pharmacodynamic antagonism. (
  • Variation in mothers' arginine vasopressin receptor 1a and dopamine receptor D4 predicts mat. (
  • amitriptyline increases effects of vasopressin by pharmacodynamic synergism. (
  • Recent animal studies suggest that stimulation of 5HT activity also induces the release of arginine-vasopressin (AVP). (
  • A target-driven DNA-based molecular machine for rapid and homogeneous detection of arginine-vasopressin. (
  • Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE . (
  • Specifically, I am confused about my son's Arginine Vasopressin (AVP antidiuretic hormone) results and how they relate to this issue. (
  • injection, USP 4 mcg/mL is a synthetic analogue of the natural pituitary hormone 8-arginine vasopressin (ADH), an antidiuretic hormone affecting renal water conservation. (
  • The change in structure of arginine vasopressin to desmopressin acetate has resulted in a decreased vasopressor action and decreased actions on visceral smooth muscle relative to the enhanced antidiuretic activity, so that clinically effective antidiuretic doses are usually below threshold levels for effects on vascular or visceral smooth muscle. (
  • Syndrome of inappropriate antidiuretic hormone (SIADH) is defined as euvolemic, hypotonic hyponatremia secondary to impaired free water excretion, usually from excessive arginine vasopressin (AVP) release. (
  • Vasopressin receptor antagonists (also known as vaptans) are a class of medications that compete with the antidiuretic hormone AVP for binding at the vasopressin receptor, permitting free water excretion. (
  • The impairment of free water excretion is caused by increased arginine vasopressin (antidiuretic hormone or AVP) release. (
  • 5. Hyponatremia and inappropriate secretion of vasopressin (antidiuretic hormone) in patients with hypopituitarism. (
  • Central DI is characterized by decreased secretion of antidiuretic hormone (ADH)-also known as arginine vasopressin (AVP)-which gives rise to polyuria and polydipsia by diminishing the person's ability to concentrate urine. (
  • The common acronyms are AVP (Arginine vasopressin) and ADH (Antidiuretic hormone), otherwise it is called argipressin. (
  • Because of its great importance for the reabsorption of water from the urine, vasopressin is also synonymously referred to as antidiuretic hormone (ADH). (
  • The cryo-EM structure of the antidiuretic hormone arginine-vasopressin V2 receptor signaling complex Arginine-vasopressin (AVP) is known as. (
  • Treatment of primary nocturnal enuresis using 1-deamino-8- d -arginine-vasopressin is based on the hypothesis that antidiuretic hormone (arginine vasopressin [AVP]) secretion is insufficient during the night. (
  • Diabetes insipidus is caused by problems with a hormone called vasopressin AVPalso called antidiuretic hormone ADH. (
  • Recent molecular genetic studies of the human arginine vasopressin 1a (AVPR1a) and oxytocin (OXTR) receptors have strengthened the evidence regarding the role of these two neuropeptides in a range of normal and pathological behaviours. (
  • Allele' uses letters from a single gene called arginine vasopressin receptor 1A (AVPR1A) and its variants . (
  • Signatures of positive selection in the cis-regulatory sequences of the human oxytocin receptor (OXTR) and arginine vasopressin receptor 1a (AVPR1A) genes. (
  • Association between arginine vasopressin 1a receptor (AVPR1a) promoter region polymorphisms and prepulse inhibition. (
  • Ebstein and his colleagues decided to look at AVPR1a because it is known to produce receptors in the brain that detect vasopressin, a hormone involved in altruism and 'prosocial' behaviour. (
  • It isn't clear how the length of AVPR1a affects vasopressin receptors: it is thought that rather than controlling the number of receptors, it may control where in the brain the receptors are distributed. (
  • Ebstein suggests the vasopressin receptors in the brains of people with short AVPR1a may be distributed in such a way to make them less likely to feel rewarded by the act of giving. (
  • This assay uses subcutaneous resistance arteries to assess the effect of your test article on vasodilation via vasopressin & oxytocin receptors. (
  • Vasopressin exerts its action mainly via binding to three receptors, which are classified as V1a, V1b and V2 receptors and belong to the family of G protein-coupled receptors. (
  • A couple of three subtypes of vasopressin antagonist Dimethyl 4-hydroxyisophthalate (VPA) receptors: V1a, V1b, and V2. (
  • Arginine vasopressin antagonist (V 1A , V 2 ) indicated for euvolemic (dilutional) and hypervolemic hyponatremia. (
  • Selective vasopressin V 2 -receptor antagonist. (
  • Effects of arginine vasopressin (AVP) and its antagonist OPC 21268 and OPC 41061 on the spontaneous activity of pulmonary vein (PV) cardiomyocytes. (
  • 9. Syndrome of inappropriate antidiuresis without involving inappropriate secretion of vasopressin in an elderly woman: effect of intravenous administration of the nonpeptide vasopressin V2 receptor antagonist OPC-31260. (
  • VAPRISOL ® is a vasopressin receptor antagonist indicated to raise serum sodium in hospitalized patients with euvolemic and hypervolemic hyponatremia ( 1 ). (
  • 4. ABT-436, a novel arginine vasopressin (AVP) type 1B receptor (V1B) antagonist developed by the pharmaceutical company, AbbVie, was evaluated in 148 alcohol dependent individuals. (
  • Prevention of hyponatraemia and cerebral oedema by the vasopressin antagonist d/CH2/5Tyr/Et/VAVP in rats treated with pitressin tannate. (
  • Vaprisol (conivaptan HCl, from Astellas Pharma ) Premixed injection, an arginine vasopressin (AVP) receptor antagonist, is available for the treatment of euvolemic and hypervolemic hyponatremia in hospitalized patients. (
  • It really is a non-selective vasopressin receptor antagonist. (
  • Glucagon-secreting alpha-cells express high levels of the vasopressin 1b receptor gene (Avpr1b). (
  • AVPR1B acts as a receptor for arginine vasopressin. (
  • V1b Vasopressin R/AVPR1B " has 6 results in Products. (
  • The subject invention describes the arginine vasopressin receptor 1B (AVPR1B) stimulatory molecules that can be used to stimulate hematopoietic stem cell proliferation. (
  • Activation of heme oxygenase and consequent carbon monoxide formation inhibits the release of arginine vasopressin from rat hypothalamic explants. (
  • To determine whether pulmonary and systemic vascular responses to arginine vasopressin (AVP) are altered by hypoxic adaptation, AVP, and, as a control, phenylephrine were administered intravenously in graded doses to pentobarbital anesthetized rats that had been exposed to 10% O2 at ambient pressure or room air for 28 days. (
  • Renal blood circulation (RBF) responses to arginine vasopressin (AVP) were analyzed in anesthetized wild-type (WT) and Compact disc38? (
  • The efficacy of arginine vasopressin V(2) receptor antagonists warrants study as an alternative treatment to loop diuretics for volume overload in these patients. (
  • 15. The use of vasopressin receptor antagonists in hyponatremia. (
  • The various available treatment approaches, including water restriction, demeclocycline, loop diuretics with NaCl supplementation, urea, and vasopressin antagonists are summarized, with emphasis on the efficacy and limitations of each of these therapies. (
  • 4] Vaptans are nonpeptide vasopressin antagonists that act by inhibiting ADH, also called arginine vasopressin (AVP). (
  • injection 4 mcg/mL contains as active substance, desmopressin acetate,USP, a synthetic analogue of the natural hormone arginine vasopressin. (
  • Desmopressin acetate has been shown to be more potent than arginine vasopressin in increasing plasma levels of factor VIII activity in patients with hemophilia and von Willebrand's disease Type I. (
  • The biphasic half-lives of desmopressin acetate were 7.8 and 75.5 minutes for the fast and slow phases, respectively, compared with 2.5 and 14.5 minutes for lysine vasopressin, another form of the hormone. (
  • The effect of oral desmopressin (1-deamino-8-D-arginine-vasopressin) (DDAVP® tablets, Minirin®) was investigated in 25 adolescents (ages 11 to 21 years) with severe monosymptomatic nocturnal enuresis. (
  • Well-defined group of adult men with type 1 diabetes, compared with and drs are not increases arginine vasopressin (AVP) immunoreactivity ( Grimes. (
  • One study found that the Swedish massage technique increases arginine vasopressin. (
  • The aims of this study were to determine the efficacy of three classes of antiemetic drugs in a novel low dose cisplatin model of nausea and vomiting and measure change in potential nausea biomarkers arginine vasopressin (AVP) and cortisol. (
  • Blood and cerebrospinal fluid samples were collected and assayed for testosterone, cortisol, oxytocin, and vasopressin. (
  • Effects of intravenous administering of interleukin-1-beta on the disenthral of prostaglandin E2, corticotropin-releasing factor, and arginine vasopressin in sundry hypothalamic areas of smoothly impressive rats: esteem past moveВ-run away perfusion. (
  • Upregulation of hypothalamic arginine vasopressin by peripherally administered furosemide in transgenic rats expressing arginine vasopressin-enhanced green fluorescent protein. (
  • To clarify the characteristics of vasopressin (AVP) secretion in patients with the syndrome of inappropriate antidiuresis (SIAD) related to central nervous system disorders, we examined the response of AVP secretion to osmotic stimulus by hypertonic saline infusion and analyzed the possible causative factors in six patients with SIAD associated with head trauma or cerebral infarction. (
  • 11. Regulation of arginine vasopressin in the syndrome of inappropriate antidiuresis. (
  • Association of copeptin, a surrogate marker of arginine vasopressin, with decreased kidney function in sugarcane workers in Guatemala. (
  • With the establishment of copeptin, a stable and reliable surrogate marker for arginine vasopressin, diagnosis of the polyuria-polydipsia syndrome has been newly evaluated. (
  • The importance of vasopressin for the reabsorption of water from the urine in the kidney becomes clear from the clinical picture of diabetes insipidus, which is caused by a deficiency of the hormone, e.g. owing to hypophysis damage. (
  • High concentration of vasopressin promotes the reabsorption of water and other compounds in the kidney by making the kidney tubules more permeable to water. (
  • 7. Inappropriate antidiuresis associated with pituitary adenoma--mechanisms not involving inappropriate secretion of vasopressin. (
  • Conversely, the secretion of vasopressin is inhibited by an increase in the intravascular volume, e.g. as result of increased fluid intake. (
  • Copeptin, arginine vasopressin (AVP)-associated 39 aminoacid glycopeptide, is a C-terminal part of pro-AVP. (
  • The aims of this study were to examine whether the vasopressin pathway, as measured by copeptin, is associated with the presence of kidney dysfunction, and to examine whether higher fluid intake is associated with lower circulating copeptin and thereby preserves kidney health among sugarcane workers exposed to hot conditions. (
  • This gene encodes a precursor protein consisting of arginine vasopressin and two associated proteins, neurophysin 2 and a glycopeptide, copeptin. (
  • Sixty-five healthy volunteers underwent either the hypertonic saline or arginine infusion test, known to stimulate copeptin, or the oral macimorelin test, known to stimulate growth hormone. (
  • Plasma oxytocin was measured before and once plasma sodium level ≥ 150 mmol/L for the hypertonic saline, after 60 min for the arginine infusion, and after 45 min for the oral macimorelin test (expected peak of copeptin and growth hormone levels, respectively). (
  • Dr. The necessary protein encrypted through this gene will act as receptor to own arginine vasopressin. (
  • Here, we show that arginine-vasopressin (AVP), secreted from the posterior pituitary, stimulates glucagon secretion. (
  • A deficiency of all anterior pituitary hormones, without necessary involvement of the hormones of the posterior pituitary gland (oxytocin and vasopressin). (
  • This model demonstrates that the diverse electrical patterns, including spiking and bursting, seen in pituitary corticotrophs in response to corticotropin releasing hormone and arginine vasopressin can be accounted for by variation in as few as two parameters. (
  • Vasopressin is a peptide hormone that is secreted from the posterior pituitary. (
  • The posterior pituitary does not synthesize vasopressin. (
  • Rather, vasopressin is produced in the hypothalamus , and then stored in the posterior pituitary for impending secretion. (
  • The value of a 7-h water deprivation test incorporating urinary osmolality and urinary arginine vasopressin (AVP) measurements was investigated in 20 children with suspected anterior or posterior pituitary dysfunction (group A) and 11 presenting with polyuria and polydipsia (group B). A control group of 16 healthy children was also studied. (
  • The posterior pituitary gland secretes two hormones, arginine vasopressin (AVP) and oxytocin. (
  • abstract = "The effects of extracellular application of arginine vasopressin (AVP) upon membrane currents in L6 skeletal myocytes was investigated using the whole-cell configuration of the patch-clamp technique. (
  • Effects of prolonged vasopressin treatment in Brattleboro rats with diabetes insipidus. (
  • [4] In addition to sex hormones, neurotransmitters such as oxytocin (OT) and arginine-vasopressin (AVP) are involved in mediating social recognition of demonstrator and target as well in sexual approach to target males. (
  • The vasopressins are peptide hormones, particularly nonapeptide (i.e. having nine amino acids). (
  • Oksche A, Moller A, Dickson J, Rosendahl W, Rascher W, Bichet DG, Rosenthal W: Two novel mutations in the aquaporin-2 and the vasopressin V2 receptor genes in patients with congenital nephrogenic diabetes insipidus. (
  • Vargas-Poussou R, Forestier L, Dautzenberg MD, Niaudet P, Dechaux M, Antignac C: Mutations in the vasopressin V2 receptor and aquaporin-2 genes in 12 families with congenital nephrogenic diabetes insipidus. (
  • Variation in mothers' arginine vasopressin receptor 1a and dopamine receptor D4 genes predicts maternal sensitivity via social cognition. (
  • Oxytocin receptor and vasopressin receptor 1a genes are respectively associated with emotional and cognitive empathy. (
  • for example, it modifies epigenetic methylation to cause hypomethylation of arginine vasopressin-related genes in the medial amygdala to greatly decrease predator aversion. (
  • Arginine vasopressin (AVP) is an important hormone for osmoregulation, while as a neuropeptide in the brain it plays an important role in the regulation of social behaviors. (
  • Influence of preventive use of vasopressin tannate on diabetes insipidus and serum sodium at the early postoperation of craniopharyngioma]. (
  • The protein expression of the corticotropin-releasing hormone (CRH) receptor 1 (CRH-R1) was decreased in CSC mice while the protein expression of the arginine vasopressin (AVP) receptor 1b (AVPR-1b) was unchanged. (
  • 2016) describe central diabetes insipidus due to impaired secretion of arginine vasopressin could result from traumatic brain injury, surgery, or tumors whereas nephrogenic diabetes insipidus due to failure of the kidney to respond to arginine vasopressin is usually inherited. (
  • Arginine vasopressin (AVP), a nine amino acid neuropeptide (CYFQNCPRG- NH2) fulfills a dual function: (i) in the periphery, AVP acts as a peptide hormone and (ii) in the CNS, AVP is a neuromodulatory peptide. (
  • Vasopressin is actually a peptide hormone. (
  • The peptide hormone vasopressin is of central importance in this [Schrier R. W., Abraham, W. T. (
  • A target-driven DNA-based molecular machine for rapid and homogeneous detection of arginine-vasopressin. (
  • Ph.D. (Docteur en Sciences Biomédicales), Cellular and Molecular Pharmacology & Toxicology Unit, Christian de Duve Inst. (
  • 2. Pancreatic Neuroendocrine Tumor Producing Insulin and Vasopressin. (
  • He and his collaborators hold international patents to develop innovative therapies for erythropoietin-responsive anemia, water balance disorders, diet-induced obesity and insulin resistance, and vasopressin excessive states, such as cirrhosis of liver, autosomal dominant polycystic kidney disease (ADPKD) and others. (
  • Effects of low-volume hemoglobin glutamer-200 versus normal saline and arginine vasopressin resuscitation on systemic and skeletal muscle blood flow and oxygenation in a canine hemorrhagic shock model. (
  • OBJECTIVE: To test the hypothesis that low-volume resuscitation with hemoglobin glutamer-200 improves hemodynamic function and tissue oxygenation, whereas arginine vasopressin resuscitation improves blood pressures more than low-volume saline or hemoglobin glutamer infusion but compromises systemic and muscle blood flow and oxygenation. (
  • Dogs were resuscitated over 60 mins with saline (8.5 mL/kg), arginine vasopressin (0.4 IU/kg bolus plus 0.08 IU x kg x min), or 1:1 diluted hemoglobin glutamer-200. (
  • Saline resuscitation increased both Do2I and muscle perfusion by 42% and 51%, while arginine vasopressin treatment reduced heart rate by 31% and increased mean arterial pressure by 22% but not cardiac output, Do2I, or muscle blood flow, resulting in a further decrease of PMo2 by 68% and worse metabolic acidosis. (
  • CONCLUSIONS: Low-volume crystalloid or hemoglobin glutamer-200 resuscitation posthemorrhage may improve (but not restore) macro- and microvascular functions and tissue oxygenation, while arginine vasopressin infusion may only improve blood pressures and result in lower overall systemic perfusion compared with low-volume saline or hemoglobin glutamer-200 treatment and worsening of anaerobic conditions in skeletal muscle. (
  • Vasopressin antibody LS-C743838 is an unconjugated rabbit polyclonal antibody to human Vasopressin (AVP / ADH). (
  • There are 4 forms of vasopressins that are identified and occur naturally in vertebrates: (1) arginine vasopressin (or agripressin), (2) lysine vasopressin (or lypressin), (3) phenypressin, and (4) vasotocin. (
  • Borie AM, Dromard Y, Guillon G, Olma A, Manning M, Muscatelli F, Desarménien MG aand Jeanneteau F (2021) Correction of vasopressin deficit in the lateral septum ameliorates social deficits of mouse autism model. (
  • Beta-amyloid peptide (A beta) aggregated in Silmitasertib in vitro the brain is the main pathological characteristic of Alzheimer's disease (AD), and a significant decrease in the concentration of arginine vasopressin (AVP) in the brain of AD patients has been reported. (
  • Deen PM, Verdijk MA, Knoers NV, Wieringa B, Monnens LA, van Os CH, van Oost BA: Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. (
  • Converging evidence from both human and animal studies has highlighted the pervasive role of two neuropeptides, oxytocin (OXT) and arginine vasopressin (AVP), in mammalian social behaviours. (
  • Vasotocin is a vasopressin that is found in non-mammalian vertebrates. (
  • The aim of this study was to identify if there is any correlation between arginine vasopressin promoter polymorphisms and PE. (
  • Along with changes in the brain, the experience of caring stimulates changes in fathers' biology-for example, hormonal changes that are similar to those mothers undergo, involving oxytocin, prolactin, glucocorticoids, oestrogen, arginine, vasopressin and testosterone. (
  • Erowid Reference 1258 : Arginine vasopressin release in response to the administration of 3,4- methylenedioxymethamphetamine ('ecstasy'): is metabolism a contributory factor? (
  • NALP6 acts as an arginine-vasopressin V2 receptor and has been suggested to contribute to AVP-mediated regulation of renal salt-water balance, glucose and lipid metabolism, apoptosis, and/or cell cycle. (
  • Together with corticotropin-releasing hormone (CRH), vasopressin regulates the basal and stress-induced secretion of adrenocorticotropic hormone (ACTH) via the V1b receptor. (
  • The Swedish massage group also experienced a decrease in arginine vasopressin, a hormone linked with aggressive behavior. (
  • There was no change to arginine infusion ( P = 0.4), and a trend to lower stimulated levels to oral macimorelin ( P = 0.05). (
  • Arg-vasopressin is used to treat diabetes insipidus or to improve vasomotor tone and blood pressure . (
  • Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes. (
  • Diabetes insipidus is simply excessive urination polyuria and complications thereof, caused by an antidiuretice hormone called a vasopressin. (
  • Excessive thirst occurs in diabetes insipidus because the body senses a lack of Vasopressin, and so it demands more fluids because it thinks it needs them. (
  • Gosling, M, Smith, JW & Poyner, DR 1995, ' Activation of calcium-sensitive potassium channels in L6 skeletal myocytes by arginine vasopressin requires extracellular calcium ', Biochemical and Biophysical Research Communications , vol. 217, no. 3, pp. 1163-1168. (
  • It releases vasopressin into the circulation in response to hypertonicity or hyperosmolality of the extracellular fluid. (
  • Oxytocin and vasopressin in the human brain: social neuropeptides for translational medicine. (
  • Balance of brain oxytocin and vasopressin: implications for anxiety, depression, and social behaviors. (