The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.
A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.
Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.
A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
A mutant strain of Rattus norvegicus used in research on renal function and hypertension and as a disease model for diabetes insipidus.
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
Hormones released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). They include a number of peptides which are formed in the NEURONS in the HYPOTHALAMUS, bound to NEUROPHYSINS, and stored in the nerve terminals in the posterior pituitary. Upon stimulation, these peptides are released into the hypophysial portal vessel blood.
Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).
The porcine antidiuretic hormone (VASOPRESSINS). It is a cyclic nonapeptide that differs from ARG-VASOPRESSIN by one amino acid, containing a LYSINE at residue 8 instead of an ARGININE. Lys-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
The withholding of water in a structured experimental situation.
Aquaporin 2 is a water-specific channel protein that is expressed in KIDNEY COLLECTING DUCTS. The translocation of aquaporin 2 to the apical PLASMA MEMBRANE is regulated by VASOPRESSIN, and MUTATIONS in AQP2 have been implicated in a variety of kidney disorders including DIABETES INSIPIDUS.
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
An increase in the excretion of URINE. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Straight tubes commencing in the radiate part of the kidney cortex where they receive the curved ends of the distal convoluted tubules. In the medulla the collecting tubules of each pyramid converge to join a central tube (duct of Bellini) which opens on the summit of the papilla.
A condition of HYPONATREMIA and renal salt loss attributed to overexpansion of BODY FLUIDS resulting from sustained release of ANTIDIURETIC HORMONES which stimulates renal resorption of water. It is characterized by normal KIDNEY function, high urine OSMOLALITY, low serum osmolality, and neurological dysfunction. Etiologies include ADH-producing neoplasms, injuries or diseases involving the HYPOTHALAMUS, the PITUITARY GLAND, and the LUNG. This syndrome can also be drug-induced.
A drive stemming from a physiological need for WATER.
Agents that reduce the excretion of URINE, most notably the octapeptide VASOPRESSINS.
Hypothalamic nucleus overlying the beginning of the OPTIC TRACT.
Urination of a large volume of urine with an increase in urinary frequency, commonly seen in diabetes (DIABETES MELLITUS; DIABETES INSIPIDUS).
Hypertonic sodium chloride solution. A solution having an osmotic pressure greater than that of physiologic salt solution (0.9 g NaCl in 100 ml purified water).
An anterior pituitary hormone that stimulates the ADRENAL CORTEX and its production of CORTICOSTEROIDS. ACTH is a 39-amino acid polypeptide of which the N-terminal 24-amino acid segment is identical in all species and contains the adrenocorticotrophic activity. Upon further tissue-specific processing, ACTH can yield ALPHA-MSH and corticotrophin-like intermediate lobe peptide (CLIP).
The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.
A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
Aquaporin 6 is an aquaglyceroporin that is found primarily in KIDNEY COLLECTING DUCTS. AQP6 protein functions as an anion-selective channel.
Nucleus in the anterior part of the HYPOTHALAMUS.
A collection of NEURONS, tracts of NERVE FIBERS, endocrine tissue, and blood vessels in the HYPOTHALAMUS and the PITUITARY GLAND. This hypothalamo-hypophyseal portal circulation provides the mechanism for hypothalamic neuroendocrine (HYPOTHALAMIC HORMONES) regulation of pituitary function and the release of various PITUITARY HORMONES into the systemic circulation to maintain HOMEOSTASIS.
An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.
Cell surface proteins that bind oxytocin with high affinity and trigger intracellular changes which influence the behavior of cells. Oxytocin receptors in the uterus and the mammary glands mediate the hormone's stimulation of contraction and milk ejection. The presence of oxytocin and oxytocin receptors in neurons of the brain probably reflects an additional role as a neurotransmitter.
Drugs used to cause constriction of the blood vessels.
The condition that results from excessive loss of water from a living organism.
Ventral part of the DIENCEPHALON extending from the region of the OPTIC CHIASM to the caudal border of the MAMMILLARY BODIES and forming the inferior and lateral walls of the THIRD VENTRICLE.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
The ability of the kidney to excrete in the urine high concentrations of solutes from the blood plasma.
Liquid by-product of excretion produced in the kidneys, temporarily stored in the bladder until discharge through the URETHRA.
Injections into the cerebral ventricles.
A member of the alkali group of metals. It has the atomic symbol Na, atomic number 11, and atomic weight 23.
The interactions between the anterior pituitary and adrenal glands, in which corticotropin (ACTH) stimulates the adrenal cortex and adrenal cortical hormones suppress the production of corticotropin by the anterior pituitary.
The front portion of the HYPOTHALAMUS separated into the preoptic region and the supraoptic region. The preoptic region is made up of the periventricular GRAY MATTER of the rostral portion of the THIRD VENTRICLE and contains the preoptic ventricular nucleus and the medial preoptic nucleus. The supraoptic region contains the PARAVENTRICULAR HYPOTHALAMIC NUCLEUS, the SUPRAOPTIC NUCLEUS, the ANTERIOR HYPOTHALAMIC NUCLEUS, and the SUPRACHIASMATIC NUCLEUS.
PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
A class of porins that allow the passage of WATER and other small molecules across CELL MEMBRANES.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The consumption of liquids.
A genetic or acquired polyuric disorder caused by a deficiency of VASOPRESSINS secreted by the NEUROHYPOPHYSIS. Clinical signs include the excretion of large volumes of dilute URINE; HYPERNATREMIA; THIRST; and polydipsia. Etiologies include HEAD TRAUMA; surgeries and diseases involving the HYPOTHALAMUS and the PITUITARY GLAND. This disorder may also be caused by mutations of genes such as ARVP encoding vasopressin and its corresponding neurophysin (NEUROPHYSINS).
Chemical substances which inhibit the function of the endocrine glands, the biosynthesis of their secreted hormones, or the action of hormones upon their specific sites.
A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS.
Compounds with BENZENE fused to AZEPINES.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Excessive amount of sodium in the blood. (Dorland, 27th ed)
An adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.
Raised area at the infundibular region of the HYPOTHALAMUS at the floor of the BRAIN, ventral to the THIRD VENTRICLE and adjacent to the ARCUATE NUCLEUS OF HYPOTHALAMUS. It contains the terminals of hypothalamic neurons and the capillary network of hypophyseal portal system, thus serving as a neuroendocrine link between the brain and the PITUITARY GLAND.
Cell surface proteins that bind ANGIOTENSINS and trigger intracellular changes influencing the behavior of cells.
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Receptors in the vascular system, particularly the aorta and carotid sinus, which are sensitive to stretch of the vessel walls.
Fluids composed mainly of water found within the body.
Tendency of fluids (e.g., water) to move from the less concentrated to the more concentrated side of a semipermeable membrane.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
Sodium excretion by URINATION.
Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.
Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
An adrenocortical steroid that has modest but significant activities as a mineralocorticoid and a glucocorticoid. (From Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p1437)
Chemical substances having a specific regulatory effect on the activity of a certain organ or organs. The term was originally applied to substances secreted by various ENDOCRINE GLANDS and transported in the bloodstream to the target organs. It is sometimes extended to include those substances that are not produced by the endocrine glands but that have similar effects.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A pathological condition manifested by failure to perfuse or oxygenate vital organs.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The main glucocorticoid secreted by the ADRENAL CORTEX. Its synthetic counterpart is used, either as an injection or topically, in the treatment of inflammation, allergy, collagen diseases, asthma, adrenocortical deficiency, shock, and some neoplastic conditions.
The active sympathomimetic hormone from the ADRENAL MEDULLA. It stimulates both the alpha- and beta- adrenergic systems, causes systemic VASOCONSTRICTION and gastrointestinal relaxation, stimulates the HEART, and dilates BRONCHI and cerebral vessels. It is used in ASTHMA and CARDIAC FAILURE and to delay absorption of local ANESTHETICS.
Elements of limited time intervals, contributing to particular results or situations.
Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The anterior glandular lobe of the pituitary gland, also known as the adenohypophysis. It secretes the ADENOHYPOPHYSEAL HORMONES that regulate vital functions such as GROWTH; METABOLISM; and REPRODUCTION.
A group of compounds consisting in part of two rings sharing one atom (usually a carbon) in common.
Use of a device for the purpose of controlling movement of all or part of the body. Splinting and casting are FRACTURE FIXATION.
Liquid components of living organisms.
An octapeptide analog of angiotensin II (bovine) with amino acids 1 and 8 replaced with sarcosine and alanine, respectively. It is a highly specific competitive inhibitor of angiotensin II that is used in the diagnosis of HYPERTENSION.
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.
The number of times the HEART VENTRICLES contract per unit of time, usually per minute.
A highly specific (Leu-Leu) endopeptidase that generates ANGIOTENSIN I from its precursor ANGIOTENSINOGEN, leading to a cascade of reactions which elevate BLOOD PRESSURE and increase sodium retention by the kidney in the RENIN-ANGIOTENSIN SYSTEM. The enzyme was formerly listed as EC 3.4.99.19.
Abnormally low BLOOD PRESSURE that can result in inadequate blood flow to the brain and other vital organs. Common symptom is DIZZINESS but greater negative impacts on the body occur when there is prolonged depravation of oxygen and nutrients.
Involuntary discharge of URINE during sleep at night after expected age of completed development of urinary control.
The U-shaped portion of the renal tubule in the KIDNEY MEDULLA, consisting of a descending limb and an ascending limb. It is situated between the PROXIMAL KIDNEY TUBULE and the DISTAL KIDNEY TUBULE.
Solutions that have a greater osmotic pressure than a reference solution such as blood, plasma, or interstitial fluid.
An ovoid densely packed collection of small cells of the anterior hypothalamus lying close to the midline in a shallow impression of the OPTIC CHIASM.
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
A small, unpaired gland situated in the SELLA TURCICA. It is connected to the HYPOTHALAMUS by a short stalk which is called the INFUNDIBULUM.
The force that opposes the flow of BLOOD through a vascular bed. It is equal to the difference in BLOOD PRESSURE across the vascular bed divided by the CARDIAC OUTPUT.
A non-steroidal anti-inflammatory agent (NSAID) that inhibits the enzyme cyclooxygenase necessary for the formation of prostaglandins and other autacoids. It also inhibits the motility of polymorphonuclear leukocytes.
The circulation of the BLOOD through the vessels of the KIDNEY.
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.
A hormone secreted by the ADRENAL CORTEX that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium.
The rate dynamics in chemical or physical systems.
A reagent that is highly selective for the modification of arginyl residues. It is used to selectively inhibit various enzymes and acts as an energy transfer inhibitor in photophosphorylation.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
Phosphoric acid esters of inositol. They include mono- and polyphosphoric acid esters, with the exception of inositol hexaphosphate which is PHYTIC ACID.
Disturbances in the body's WATER-ELECTROLYTE BALANCE.
A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.
The physiological narrowing of BLOOD VESSELS by contraction of the VASCULAR SMOOTH MUSCLE.
A ubiquitous sodium salt that is commonly used to season food.
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
An enzyme of the lyase class that catalyzes the formation of CYCLIC AMP and pyrophosphate from ATP. EC 4.6.1.1.
The nonstriated involuntary muscle tissue of blood vessels.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.
The increase in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A system of NEURONS that has the specialized function to produce and secrete HORMONES, and that constitutes, in whole or in part, an ENDOCRINE SYSTEM or organ.
The most common and most biologically active of the mammalian prostaglandins. It exhibits most biological activities characteristic of prostaglandins and has been used extensively as an oxytocic agent. The compound also displays a protective effect on the intestinal mucosa.
Sense of awareness of self and of the environment.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Established cell cultures that have the potential to propagate indefinitely.

Oxytocin and vasopressin receptors in human and uterine myomas during menstrual cycle and early pregnancy. (1/1807)

The purpose of this study was to determine the specificity and concentration of oxytocin (OT) and arginine vasopressin (AVP) binding sites in non-pregnant (NP) human and rhesus monkey endometrium, myometrium and fibromyomas, and to determine the cellular localization of OT receptor (OTR). Besides [3H]AVP, [125I]LVA, a specific VP1 receptor subtype antagonist, was used to determine vasopressin receptor (VPR) concentrations. Samples were obtained from 42 pre-menopausal and three pregnant women (5, 13 and 35 weeks gestation), and several NP and pregnant monkeys. Specificity of binding was assessed in competition experiments with unlabelled agonists and antagonists of known pharmacological potency. Cellular localization of OTR was determined by immunohistochemistry. In NP human uterine tissues, [3H]AVP was bound with higher affinity and greater binding capacity than [3H]OT, whereas in pregnant women and in NP and pregnant rhesus monkeys, uterine OT binding capacity was greater. OT and AVP binding sites discriminated very poorly between OT and AVP; [125I]LVA binding sites were more selective than [3H]AVP. Their ligand specificity and binding kinetics indicated the presence of two distinct populations of binding sites for OT and AVP in primate uterus. Endometrium of NP women and monkeys had low OTR and VPR concentrations. Myometrial and endometrial OTR and VPR were down-regulated in midcycle and in early human pregnancy, they were up-regulated in the secretory phase and second half of pregnancy. Immunoreactive OTR in NP uterus was localized in patches of myometrial muscle cells and small numbers of endometrial epithelial cells.  (+info)

Physiological variability of fluid-regulation hormones in young women. (2/1807)

We tested the physiological reliability of plasma renin activity (PRA) and plasma concentrations of arginine vasopressin (P[AVP]), aldosterone (P[ALD]), and atrial natriuretic peptide (P[ANP]) in the early follicular phase and midluteal phases over the course of two menstrual cycles (n = 9 women, ages 25 +/- 1 yr). The reliability (Cronbach's alpha >/=0.80) of these hormones within a given phase of the cycle was tested 1) at rest, 2) after 2.5 h of dehydrating exercise, and 3) during a rehydration period. The mean hormone concentrations were similar within both the early follicular and midluteal phase tests; and the mean concentrations of P[ALD] and PRA for the three test conditions were significantly greater during the midluteal compared with the early follicular phase. Although Cronbach's alpha for resting and recovery P[ANP] were high (0.80 and 0.87, respectively), the resting and rehydration values for P[AVP], P[ALD], and PRA were variable between trials for the follicular (alpha from 0.49 to 0.55) and the luteal phase (alpha from 0.25 to 0. 66). Physiological reliability was better after dehydration for P[AVP] and PRA but remained low for P[ALD]. Although resting and recovery P[AVP], P[ALD], and PRA were not consistent within a given menstrual phase, the differences in the concentrations of these hormones between the different menstrual phases far exceeded the variability within the phases, indicating that the low within-phase reliability does not prevent the detection of menstrual phase-related differences in these hormonal variables.  (+info)

Effects of arginine vasopressin on cell volume regulation in brain astrocyte in culture. (3/1807)

Astrocytes initially swell when exposed to hypotonic medium but rapidly return to normal volume by the process of regulatory volume decrease (RVD). The role that arginine vasopressin (AVP) plays in hypotonically mediated RVD in astrocytes is unknown. This study was therefore designed to determine whether AVP might play a role in astrocyte RVD. With the use of 3-O-[3H]methyl-D-glucose to determine water space, AVP treatment resulted in significantly increased 3-O-methyl-D-glucose water space within 30 s of hypotonic exposure (P = 0.0001) and remained significantly elevated above baseline (1. 75 microliter/mg protein) at 5 min (P < 0.021). In contrast, in untreated cells, complete RVD was achieved by 5 min. At 30 s, cell volume with AVP treatment was 37% greater than in cells that received no treatment (2.9 vs. 2.26 microliter/mg protein, respectively; P < 0.006). The rate of cell volume increase (dV/dt) over 30 s was highly significant (0.038 vs. 0.019 microliter. mg protein-1. s-1 in the AVP-treated vs. untreated group; P = 0.0004 by regression analysis). Additionally, the rate of cell volume decrease over the next 4.5 min was also significantly greater with vasopressin treatment (-dV/dt = 0.0027 vs. 0.0013 microliter. mg protein-1. s-1; P = 0.0306). The effect of AVP was concentration dependent with EC50 = 3.5 nM. To determine whether AVP action was receptor mediated, we performed RVD studies in the presence of the V1-receptor antagonists benzamil and ethylisopropryl amiloride and the V2-receptor agonist 1-desamino-8-D-arginine vasopressin (DDAVP). Both V1-receptor antagonists significantly inhibited AVP-mediated volume increase by 40-47% (P < 0.005), whereas DDAVP had no stimulatory effects above control. Taken together, these data suggest that AVP treatment of brain astrocytes in culture appears to increase 3-O-methyl-D-glucose water space during RVD through V1 receptor-mediated mechanisms. The significance of these findings is presently unclear.  (+info)

AVP inhibits LPS- and IL-1beta-stimulated NO and cGMP via V1 receptor in cultured rat mesangial cells. (4/1807)

The present study examined how arginine vasopressin (AVP) affects nitric oxide (NO) metabolism in cultured rat glomerular mesangial cells (GMC). GMC were incubated with test agents and nitrite, and intracellular cGMP content, inducible nitric oxide synthase (iNOS) mRNA, and iNOS protein were analyzed by the Griess method, enzyme immunoassay, and Northern and Western blotting, respectively. AVP inhibited lipopolysaccharide (LPS)- and interleukin-1beta (IL-1beta)-induced nitrite production in a dose- and time-dependent manner, with concomitant changes in cGMP content, iNOS mRNA, and iNOS protein. This inhibition by AVP was reversed by V1- but not by oxytocin-receptor antagonist. Inhibition by AVP was also reproduced on LPS and interferon-gamma (IFN-gamma). Protein kinase C (PKC) inhibitors reversed AVP inhibition, whereas PKC activator inhibited nitrite production. Although dexamethasone and pyrrolidinedithiocarbamate (PDTC), inhibitors of nuclear factor-kappaB, inhibited nitrite production, further inhibition by AVP was not observed. AVP did not show further inhibition of nitrite production with actinomycin D, an inhibitor of transcription, or cycloheximide, an inhibitor of protein synthesis. In conclusion, AVP inhibits LPS- and IL-1beta-induced NO production through a V1 receptor. The inhibitory action of AVP involves both the activation of PKC and the transcription of iNOS mRNA in cultured rat GMC.  (+info)

Local regulation of vasopressin and oxytocin secretion by extracellular ATP in the isolated posterior lobe of the rat hypophysis. (5/1807)

It is now widely accepted that ATP functions as a signalling substance in the nervous system. The presence of P2 receptors mediating the action of extracellular ATP in brain regions involved in hormonal regulation raises the possibility that a similar role for ATP might also exist in the neuroendocrine system. In this study, the release from the rat isolated neurohypophysis preparation of endogenous ATP, oxytocin and vasopressin (AVP) were measured simultaneously using luciferin-luciferase and RIA techniques. After 70 min preperfusion, electrical field stimulation caused a rapid increase in the amount of ATP in the effluent and the release of AVP and oxytocin also increased stimulation-dependently. Inhibition of voltage-dependent Na+ channels by tetrodotoxin (1 microM) reduced the stimulation-evoked release of AVP and oxytocin; however, the evoked release of ATP remained unaffected. The effect of endogenous ATP on the hormone secretion was tested by suramin (300 microM), the P2 receptor antagonist. Suramin significantly increased the release of AVP, and the release of oxytocin was also enhanced. ATP, when applied to the superfusing medium, decreased the release of AVP, but not that of oxytocin, and its effect was prevented by suramin. ATP (60 nmol), added to the tissues, was readily decomposed to ADP, AMP and adenosine measured by HPLC combined with ultraviolet light detection, and the kinetic parameters of the enzymes responsible for inactivation of ATP (ectoATPase and ecto5'-nucleotidase) were also determined (Km=264+/-2.7 and 334+/-165 microM and vmax=6.7+/-1.1 and 2.54+/-0.24 nmol/min per preparation (n=3) for ectoATPase and ecto5'-nucleotidase respectively). Taken together, our data demonstrate the stimulation-dependent release, P2 receptor-mediated action and extracellular metabolism of endogenous ATP in the posterior lobe of the hypophysis and indicate its role, as a paracrine regulator, in the local control of hormone secretion.  (+info)

Repeated administration of vasopressin but not epinephrine maintains coronary perfusion pressure after early and late administration during prolonged cardiopulmonary resuscitation in pigs. (6/1807)

BACKGROUND: It is unknown whether repeated dosages of vasopressin or epinephrine given early or late during basic life support cardiopulmonary resuscitation (CPR) may be able to increase coronary perfusion pressure above a threshold between 20 and 30 mm Hg that renders defibrillation successful. METHODS AND RESULTS: After 4 minutes of cardiac arrest, followed by 3 minutes of basic life support CPR, 12 animals were randomly assigned to receive, every 5 minutes, either vasopressin (early vasopressin: 0.4, 0.4, and 0.8 U/kg, respectively; n=6) or epinephrine (early epinephrine: 45, 45, and 200 microg/kg, respectively; n=6). Another 12 animals were randomly allocated after 4 minutes of cardiac arrest, followed by 8 minutes of basic life support CPR, to receive, every 5 minutes, either vasopressin (late vasopressin: 0.4 and 0.8 U/kg, respectively; n=6), or epinephrine (late epinephrine: 45 and 200 microg/kg, respectively; n=6). Defibrillation was attempted after 22 minutes of cardiac arrest. Mean+/-SEM coronary perfusion pressure was significantly higher 90 seconds after early vasopressin compared with early epinephrine (50+/-4 versus 34+/-3 mm Hg, P<0.02; 42+/-5 versus 15+/-3 mm Hg, P<0.0008; and 37+/-5 versus 11+/-3 mm Hg, P<0. 002, respectively). Mean+/-SEM coronary perfusion pressure was significantly higher 90 seconds after late vasopressin compared with late epinephrine (40+/-3 versus 22+/-4 mm Hg, P<0.004, and 32+/-4 versus 15+/-4 mm Hg, P<0.01, respectively). All vasopressin animals survived 60 minutes, whereas no epinephrine pig had return of spontaneous circulation (P<0.05). CONCLUSIONS: Repeated administration of vasopressin but only the first epinephrine dose given early and late during basic life support CPR maintained coronary perfusion pressure above the threshold that is needed for successful defibrillation.  (+info)

Separate receptors mediate oxytocin and vasopressin stimulation of cAMP in rat inner medullary collecting duct cells. (7/1807)

The two neurohypophysial hormones arginine vasopressin (AVP) and oxytocin have actions in the inner medullary collecting duct (IMCD) where both peptides induce an increase in cAMP accumulation. The present study has employed a novel IMCD cell line to determine whether these two hormones induce cAMP accumulation via common or separate receptors, and to characterize the potential receptors responsible. Equal volumes of vehicle (150 mM NaCl) or hormone/antagonist solutions were added to aliquots of 10(4) IMCD cells in the presence of 10(-3) M 3-isobutylmethylxanthine (IBMX) and incubated at 37 degrees C for 4 min. cAMP levels were determined by radioimmunoassay and protein concentration by Bradford assay. Both AVP and oxytocin elicited dose-dependent increases in cAMP generation, though oxytocin was less potent than AVP (EC50 = 1.6 x 10(-8) M vs. 7.4 x 10(-10) M). AVP at 10(-8) M and oxytocin at 10(-8) M, concentrations sufficient to elicit near-maximal cAMP accumulation, resulted in cAMP levels of 73.4 +/- 1.7 and 69.0 +/- 3.3 pmol (mg protein)-1 (4 min)-1, respectively (n = 10), compared with the vehicle-treated basal value of 37.7 +/- 2.2 pmol (mg protein)-1 (4 min)-1 (P < 0.001, n = 10). Combined AVP (10(-8) M) and oxytocin 10(-6) M) resulted in cAMP accumulation of 63.8 +/- 3.1 pmol (mg protein)-1 (4 min)-1 (n = 10), which was not significantly different from the effect of oxytocin alone, but slightly less than that for AVP alone (P < 0.05). A submaximal concentration of AVP (10(-10) M) induced cAMP accumulation of 48.6 +/- 2.5 pmol (mg protein)-1 (4 min)-1 (P < 0.01 compared with basal level of 34.9 +/- 2.4 pmol (mg protein)-1 (4 min)-1, n = 10), which was blocked in the presence of a vasopressin V2 receptor antagonist (10(-7) M OPC-31260) but not by the oxytocin receptor antagonist (10(-6) M [Pen1,pMePhe2, Thr4,Orn8]oxytocin) (36.3 +/- 6.1 and 45.1 +/- 1.3 pmol (mg protein)-1 (4 min)-1 respectively, P < 0.05, n = 10). A submaximal concentration of oxytocin (10(-7) M) induced a cAMP accumulation of 45.8 +/- 1.8 pmol (mg protein)-1 (4 min)-1 (n = 10), which was reduced by addition of 10(-6) M oxytocin antagonist (36.3 +/- 2.1 pmol (mg protein)-1 (4 min)-1, P < 0.05, n = 10), whereas co-incubation with 10(-6) M of the V2 receptor antagonist had no effect (43.2 +/- 1.3 pmol (mg protein)-1 (4 min)-1, n = 10). These results indicate that AVP and oxytocin induce cAMP accumulation from a common ATP pool in IMCD cells, and that separate vasopressin V2 and oxytocin receptor systems are involved, perhaps coupled to a common adenylate cyclase system.  (+info)

Mutant vasopressin precursors that cause autosomal dominant neurohypophyseal diabetes insipidus retain dimerization and impair the secretion of wild-type proteins. (8/1807)

Autosomal dominant familial neurohypophyseal diabetes insipidus is caused by mutations in the arginine vasopressin (AVP) gene. We demonstrated recently that mutant AVP precursors accumulate within the endoplasmic reticulum of neuronal cells, leading to cellular toxicity. In this study, the possibility that mutant AVP precursors interact with wild-type (WT) proteins to alter their processing and function was explored. WT and mutant precursors were epitope-tagged to allow them to be distinguished in transfected cells. An in vivo cross-linking reaction revealed homo- and heterodimer formation between WT and mutant precursors. Mutant precursors were also shown to impair intracellular trafficking of WT precursors from the endoplasmic reticulum to the Golgi apparatus. In addition to the cytotoxicity caused by mutant AVP precursors, the interaction between the WT and mutant precursors suggests that a dominant-negative mechanism may also contribute to the pathogenesis of familial neurohypophyseal diabetes insipidus.  (+info)

TY - JOUR. T1 - Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model. AU - Wenzel, Volker. AU - Kern, Karl B. AU - Hilwig, Ronald W.. AU - Berg, Robert A.. AU - Schwarzacher, Severin. AU - Butman, Samuel M.. AU - Lindner, Karl H.. AU - Ewy, Gordon A.. PY - 2005/2. Y1 - 2005/2. N2 - Although arginine vasopressin (AVP) has been shown to be a promising drug during cardiopulmonary resuscitation (CPR), concern has been raised about the potential for AVP-mediated vasoconstriction of the coronary arteries. In a prospective, randomized laboratory investigation employing an established porcine model, the effects of AVP on haemodynamic variables, left anterior descending (LAD) coronary artery cross sectional area employing intravascular ultrasound (IVUS), and return of spontaneous circulation were studied. During sinus rhythm, the LAD coronary artery cross sectional area was measured by IVUS at baseline, and 90 s and 5 min after AVP ...
Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral oxygenation during shoulder surgery in the beach chair position: a prospective, single-blind study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
Aim: To explore the association of plasma copeptin, the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon in obese men and men of normal weight. Methods: We measured fasting blood concentrations of copeptin and glucagon in 102 healthy obese men (mean ± sd age 49.4 ± 10.2 years) and a control group 27 healthy men of normal weight (mean ± sd age 51.5 ± 8.4 years). Differences between groups were evaluated using t-tests, and multiple linear regression analysis, adjusting for age and weight status (normal weight vs obese), was used to calculate unstandardized regression coefficients (β) with 95% CIs between copeptin and glucagon. Copeptin was (natural) log-transformed. Results: The obese men had higher [median (interquartile range)] plasma copeptin concentrations [6.6 (4.6-9.5) vs 4.9 (3.5-6.8) pmol/l; P = 0.040] and higher mean ± sd plasma glucagon concentrations (8.5 ± 3.8 vs 5.3 ± 1.4 pmol/l; P , 0.001) than the ...
Synonyms for arginine vasopressin hormone in Free Thesaurus. Antonyms for arginine vasopressin hormone. 3 synonyms for antidiuretic hormone: ADH, Pitressin, vasopressin. What are synonyms for arginine vasopressin hormone?
Animals were randomly allocated to four groups. In addition to a control group submitted to anaphylactic shock without any added therapy, three groups were designed according to the drug used for resuscitation: epinephrine (Aguettant, Lyon, France) only, AVP (Aguettant) only, and epinephrine followed by AVP (fig. 1). The investigator was not blinded to the drug used. The first bolus of epinephrine or AVP was injected 5 min after shock induction (T0 + 5 min). The second bolus of epinephrine was injected when the MAP began to decrease again after the initial increase following the first bolus. Doses of bolus were chosen according to our previous work.12 Two bolus of AVP followed by a continuous infusion induced the death of the animals due to multiple organs infarction (data not shown). Therefore, only one bolus of AVP was injected. To avoid any excessive volume loading, both drugs were prepared at different dilutions (in saline solution), and the syringes were changed when necessary to preserve a ...
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A New Synthetic Route to YM087, an Arginine Vasopressin Antagonist.|span||/span| | Takashi Tsunoda; Akihiro Tanaka; Toshiyasu Mase; Shuichi Sakamoto | download | BookSC. Download books for free. Find books
Arginine Vasopressin (AVP, Antidiuretic Hormone, ADH),ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. ARUP offers an extensive test menu of highly complex and unique medical tests in clinical and anatomic pathology. Owned by the University of Utah, ARUP Laboratories client,medicine,medical supply,medical supplies,medical product
Social behavior can be viewed as a varying output of an approach-avoidance conflict. For example a potential mate elicits a strong approach response and a predator induces the very opposite. Social behavior must be plastic to best adapt to a continuously changing (biotic and abiotic) environment. Different external states are mirrored by changes in levels of circulating sex hormones; presence of a mating opportunity elevates testosterone levels while presence of a stressor depresses it. I hypothesize that the plasticity in social behavior is a function of changes in circulating sex hormones; i.e. testosterone in males. Arginine vasopressin (AVP) is a neuropeptide widely implicated in social behavior. In the extrahypothalamic regions of the brain it is highly sensitive to testosterone. Castration causes a drop in AVP projections in the extrahypothalmic zone, medial amygdala (MEA); a change that can be attributed to an androgen dependent hypermethylation of the AVP promotor. For these reasons ...
Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K 8644, nifedipine or pertussis toxin Academic Article ...
The antidiuretic hormone arginine vasopressin (AVP) receptors are G protein-coupled receptors which consists of at least three types: V1A (vascular/hepatic) and V1B (anterior pituitary) receptors, which act through phosphatidylinositol hydrolysis to mobilize intracellular Ca2+; and V2 (kidney) re...
We studied the involvement of periventricular and hypothalamic angiotensinergic and cholinergic pathways in osmotically induced arginine vasopressin (AVP) release into the blood. In conscious Wistar rats, i.c.v. injections of 0.2, 0.3 and 0.6 M hyperosmolar saline (5 μl) resulted in concentration-dependent increases in AVP release (5.2 ± 1.5, 10.6 ± 2.2 and 18.0 ± 2.2 pg/ml, respectively, vs. 2.0 ± 0.1 in controls). The two lower saline concentrations did not affect arterial blood pressure (non-pressure-associated AVP release), whereas 0.6 M saline induced increase in blood pressure (pressure-associated AVP release). In the first set of experiments, periventricular angiotensin AT1, muscarinic or nicotinic receptors were blocked by i.c.v. administration of losartan (10 nmol), atropine (100 nmol) or hexamethonium (100 nmol), respectively, before i.c.v. hyperosmolar saline injections. Losartan significantly reduced the 0.2 M and 0.3 M, but not the 0.6 M, saline-induced increase in AVP release. ...
3,4-methylenedioxymethamphetamine (MDMA) and its derivatives, 2,5-dimethoxy-4-bromo-amphetamine hydrobromide (DOB) and para-methoxyamphetamine (PMA) are recreational drugs whose pharmacological effects have recently been attributed to serotonin 5HT2A/C receptors. However, there is growing evidence that the oxytocin/vasopressin system can modulate some the effects of MDMA. In this study, MDMA (2.5-10 mg/kg), DOB (0.5 mg/kg) or PMA (0.005, 0.1 or 0.25 mg/kg) were administered intramuscularly (IM) to adult zebrafish, alone or in combination with the V1a vasopressin antagonist, SR49059 (0.01-1 ng/kg), before carrying out conditioned place preference (CPP), social preference, novel tank diving and light-dark tests in order to evaluate subsequent rewarding, social and emotional-like behaviour. The combination of SR49059 and each drug progressively blocked: 1) rewarding behaviour as measured by CPP in terms of time spent in drug-paired compartment; 2) pro-social effects measured on the basis of the
Vasopressin is a potent peripheral vasoconstrictor. Vasopressin has a direct action on the kidney. It also constricts peripheral vessels and causes contraction of the smooth muscle of the intestine, gall bladder and urinary bladder.. Due to rapid inactivation by a number of enzymes that cleave the peptide at several sites, the effects of vasopressin are relatively short lived unless given by continuous infusions. ...
Participant has successfully completed Studies 15-AVP-786-301, 15-AVP-786-302, 12-AVR-131, or 17-AVP-786-305.. Participants will be enrolled in the study for approximately 56 weeks (participants who have a follow-up visit 3 months after the last dose of treatment will be enrolled for approximately 64 weeks).. Approximately 1000 participants will be enrolled at approximately 250 centers globally.. All participants enrolled will receive AVP-786; the treatment dose assigned will be masked to the participant, investigator, study staff, and the sponsor.. ...
ANSWER: Bed-wetters are not willfully wetting the bed, so they should never be punished or humiliated. At age 5, about 7 percent of boys still wet the bed. By age 10, that number decreases to 3 percent, and by age 18, only 1 percent have the problem. A smaller number of girls wet the bed. For some, its a family trait. A bladder slightly smaller than it should be for the childs age is another factor. Slowness in maturation of the nerve connections of the bladder is a possible cause. And some children secrete too little of the hormone (antidiuretic hormone, also called arginine vasopressin) that slows the production of urine during the night. Children who are in the deep stages of sleep might not respond to signals that the bladder is full ...
RESULTS: Surgery resulted in decreased ex vivo mHLA-DR expression, but no change in IL-10 or IL-12 plasma levels. mHLA-DR was low in LPS culture over the 4 postoperative days, whereas IL-10 release was increased and not counterbalanced by IL-12p40 production. The hormonal plasma pattern showed increased prolactin during anesthesia and peaks of cortisol, ACTH and arginine vasopressin during waking, but no alteration in catecholamine levels. mHLA-DR expression in LPS culture was not modified by plasma replacement, except immediately after surgery ...
Arginine HCL 400g, ALLMAX Nutrition Precursor for synthesis of Nitric Oxide (NO)* Promotes muscle mass* Arginine is considered a semi-essential amino acid. What that means is the body produces Arginine normally, but sometimes the body needs more than is available and Arginine needs to be supplemented. Food sources suc
Heres my AvP Requiem Blu-Ray Review. The film isnt a total loss, there are some genuinely good moments but the script is just awful.
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BACKGROUND: Alterations in arginine vasopressin regulation and secretion have been proposed as one possible biochemical abnormality in patients with obsessive-compulsive disorder. In golden hamsters, arginine vasopressin microinjections into the anterior hypothalamus trigger robust grooming and flank marking, a stereotyped scent marking behaviors. The intensity and repetition of the behaviors induced by arginine vasopressin is somewhat reminiscent of Obsessive Compulsive Disorder in humans. The present experiments were carried out to test whether pharmacological agents used to alleviate obsessive compulsive disorder could inhibit arginine vasopressin-induced flank marking and grooming. RESULTS: Male golden hamsters were treated daily for two weeks with either vehicle, fluoxetine, clomipramine, or desipramine (an ineffective drug), before being tested for arginine vasopressin-induced flank marking and grooming. Flank marking was significantly inhibited in animals treated with fluoxetine or clomipramine
U.S., Jan. 12 -- ClinicalTrials.gov registry received information related to the study (NCT03014063) titled Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock on Jan. 4. Brief Summary: This is a prospective observational cohort trial evaluating a single plasma vasopressin concentration in patients receiving exogenous, adjunctive vasopressin for septic shock. The trial is designed to determine whether plasma vasopressin concentration influences the likelihood of hemodynamic response to exogenous vasopressin therapy. Study Start Date: November 2016 Study Type: Observational Condition: Septic Shock Intervention: Not Provided Recruitment Status: Recruiting Sponsor: The Cleveland Clinic Information provided by (Responsible Party): The Cleveland Clinic ...
TY - JOUR. T1 - The selective vasopressin type 1a receptor agonist selepressin (FE 202158) blocks vascular leak in ovine severe sepsis. AU - Maybauer, Marc O.. AU - Maybauer, Dirk M.. AU - Enkhbaatar, Perenlei. AU - Laporte, Régent. AU - Winiewska, Halina. AU - Traber, Lillian D.. AU - Lin, Chiidean. AU - Fan, Juanjuan. AU - Hawkins, Hal K.. AU - Cox, Robert A.. AU - Winiewski, Kazimierz. AU - Schteingart, Claudio D.. AU - Landry, Donald W.. AU - Rivière, Pierre J M. AU - Traber, Daniel L.. PY - 2014. Y1 - 2014. N2 - OBJECTIVE:: To determine if the selective vasopressin type 1a receptor agonist selepressin (FE 202158) is as effective as the mixed vasopressin type 1a receptor/vasopressin V2 receptor agonist vasopressor hormone arginine vasopressin when used as a titrated first-line vasopressor therapy in an ovine model of Pseudomonas aeruginosa pneumonia-induced severe sepsis. DESIGN:: Prospective, randomized, controlled laboratory experiment. SETTING:: University animal research facility. ...
OBJECTIVE: To investigate the involvement of serotonin (5-hydroxytryptamine - 5-HT) receptors in mediation of stress-induced arginine vasopressin (AVP) and oxytocin (OT) secretion in male rats.. DESIGN: Experiments on laboratory rats with control groups.. METHODS: Different stress paradigms were applied after pretreatment with intracerebroventricular infusion of saline or different 5-HT antagonists.. RESULTS: Restraint stress (5 min), hypotensive hemorrhage or dehydration for 24 h increased AVP secretion fivefold and OT secretion threefold. Swim stress for 3 min had no effect on AVP secretion, but increased OT secretion threefold. Ether vapor or hypoglycemia had no effect on AVP or OT secretion. The restraint stress-induced AVP response was inhibited by pretreatment with the 5-HT(2A+2C) antagonists ketanserin (KET) and LY-53857 (LY) and the 5-HT(3+4) antagonist ICS-205930 (ICS), whereas the 5-HT(1A) antagonist WAY-100635 (WAY) had no effect. The OT response to restraint stress was inhibited by ...
Axon terminals in the posterior pituitary store large quantities of the hormone vasopressin (AVP), buffering the synthesizing neurons in the hypothalamus against acute changes in physiological demand for hormone release. The dynamics of pituitary AVP content reflect the competing processes of release and synthesis. This report demonstrates substantial increases in pituitary AVP content in the maturing rat. Between 7-10 weeks of age, the total pituitary AVP content in the rat increases from 957 +/- 72 to 1667 +/- 160 ng. Cross-sectional data indicate a parallel relationship between body weight and pituitary AVP content. Nevertheless, weight maintenance does not affect age-related increases in AVP content. Decreasing demand for hormone release and synthesis by inducing hyponatremia blocks subsequent pituitary accumulation. After withdrawing the hyponatremic experimental conditions, animals resume accumulation of pituitary AVP, but do not catch up to age-matched controls. This indicates that increases in
Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor antagonists from desloratadine via successive acylation, reduction and acylation reactions. Their structures were characterized by 1H-NMR and HRMS, their biological activity was evaluated by in vitro and in vivo studies. The in vitro binding assay and cAMP accumulation assay indicated that these compounds are potent selective V2 receptor antagonists. Among them compounds 1n, 1t and 1v exhibited both high affinity and promising selectivity for V2 receptors. The in vivo diuretic assay demonstrated that 1t presented remarkable diuretic activity. In conclusion, 1t is a potent novel AVP V2 receptor antagonist candidate.
Rivalland, Elizabeth T.A., Iqbal, J., Clarke, I.J., Turner, Anne I. and Tilbrook, A.J. 2003, Distribution and co-localisation of corticotrophin-releasing hormone (CRH), arginine vasopressin (AVP) and enkephalin (Enk) in the paraventricular nucleus (PVN) of the ewe, in Proceedings of the Endocrine Society of Australia, Endocrine Society of Australia, Melbourne, Vic., pp. 305-305. ...
Vasopressin-sensitive aquaporin-2 (Aqp2) in the apical membrane of the renal collecting duct (Fenton et al., 2008). Controls cell volume and thereby influences cell proliferation (Di Giusto et al. 2012). It plays a key role in concentrating urine. Water reabsorption is regulated by AQP2 trafficking between intracellular storage vesicles and the apical membrane. This process is tightly controlled by the pituitary hormone arginine vasopressin, and defective trafficking results in nephrogenic diabetes insipidus (NDI). The crystal structure of Aqp2 has been solved to 2.75Å (Frick et al. 2014). In terrestrial vertebrates, AQP2 function is generally regulated by arginine-vasopressin to accomplish key functions in osmoregulation such as the maintenance of body water homeostasis by a cyclic AMP-independent mechanism (Olesen and Fenton 2017; Martos-Sitcha et al. 2015 ...
Increasing amounts of data suggest that affective disorders might be related to dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, one of the stress-response systems. Arginine vasopressin (AVP) influences several symptoms, relevant to affective disorders, notable memory processes, pain sensitivity, synchronization of biological rhythms and the timing and quality of REM sleep. We examined whether genetic variations in the AVP receptor 1b gene (AVPR1b) could be associated with increased susceptibility to affective disorders using a gene-based association analysis of single-nucleotide polymorphisms (SNPs). Five SNPs were identified in AVPR1b and genotyped in two well-diagnosed samples of patients with recurrent major depression and matched controls. In the Swedish sample, we observed significant allele (P=0.02) and genotype (P=0.01) association with SNP AVPR1b-s3, and in the Belgian sample, a borderline significant association with SNP AVPR1b-s5 (P=0.04). In both patient-control ...
In this study we found that, in 31 normal subjects, close to 90% of circulating arginine vasopressin (AVP), measured by radioimmunoassay, was associated with platelets. By using routine methods of centrifugation, which do not completely separate platelets, the normal range of plasma vasopressin was higher by twofold than the normal range in platelet-free plasma prepared by differential centrifugation, which was 1.4 +/- 1.0 sd pg/ml. Platelet vasopressin was 12.9 +/- 5.7 pg/ml. Patients with congestive heart failure had, on average, an elevated platelet-free plasma AVP, as did two patients with thrombocytopenia and one with thrombocytosis. Patients with essential hypertension had slightly high levels of platelet-free plasma AVP and demonstrated an abnormal inverse relationship between platelet-free plasma AVP and serum osmolality. Immunoreactive platelet vasopressin was slightly low in patients with essential hypertension and was subnormal in patients with congestive heart failure. These studies ...
A novel finding of this study was that an elevated BUN level at discharge significantly modified the relationship between eGFR at discharge and the higher risk of all-cause or cardiac death after discharge, suggesting that the association between eGFR and outcomes may be largely dependent on the presence of an elevated BUN level. The mechanism underlying this association is unclear, but some assumptions can be made. It is well known that creatinine is freely filtered by the glomerulus and not reabsorbed and that it undergoes tubular secretion. In contrast, urea is freely filtered and not secreted but is reabsorbed by the renal tubules (11). Accordingly, BUN is influenced by enhanced proximal and distal tubular reabsorption caused by neurohormonal activation, the urine flow rate, and the effect of arginine vasopressin on the urea transporter in the collecting duct (1,11,26). Thus, elevation of BUN may serve as an index of neurohormonal activation over and above any decline of eGFR (11). ...
Ever wonder what attracts you to your significant other and gives you a special bond with them? A study done on monogamous voles may have surprising ties with humans. The study (http://www.nature.com/neuro/journal/v7/n10/pdf/nn1327.pdf) has found that two chemicals found in voles (and in humans) Oxytocin (OT) and Arginine Vasopressin (AV), have found to be very important in pair bonding. The chemical Oxytocin has been shown to be very important in both males and females however more so to females then males. Males on the other hand, seem to be more effected by Arginine Vasopressin which leads them to be more aggressive, mark their territory and courtship. This is interesting because both sexes show the same number of receptors for both Oxytocin and Arginine Vasopressin. The study has been able to conclude that when Oxytocin is present in both sexes, pair bonding is increased even without mating. If Oxytocin is blocked for any reason pair bonding is prevented and the animals do not show signs of ...
Oxytocin (OT) and vasopressin (AVP) play a major role in social behaviours. Mice have become the species of choice for neurobiology of social behaviour due to identification of mouse pheromones and the advantage of genetically modified mice. However, neuroanatomical data on nonapeptidergic systems in mice are fragmentary, especially concerning the central distribution of OT. Therefore, we analyse the immunoreactivity for OT and its neurophysin in the brain of male and female mice (strain CD1). Further, we combine immunofluorescent detection of OT and AVP to locate cells co-expressing both peptides and their putative axonal processes. The results indicate that OT is present in cells of the neurosecretory paraventricular (Pa) and supraoptic hypothalamic nuclei (SON). From the anterior SON, OTergic cells extend into the medial amygdala, where a sparse cell population occupies its ventral anterior and posterior divisions. Co-expression of OT and AVP in these nuclei is rare. Moreover, a remarkable ...
The major findings of this study were that in the perfused rat CCD, the selective alpha-2 agonist dexmedetomidine reduced (1) AVP-stimulated Pf by 95% to 100%, (2) AVP-stimulated Pf in the presence of the PKC inhibitor staurosporine by 70% to 75% and (3) 8CPT-cAMP-stimulated Pf by 25% to 35%. Dexmedetomidine significantly reversed the AVP-induced effects on Vt and Rt. Overall, these findings indicate analpha-2-mediated mechanism that modulates AVP-dependent Na+ and water transport in the rat CCD, and the mechanism appears to include post-cAMP events in addition to the pre-cAMP event of alpha-2-induced inhibition of adenylyl cyclase.. Although the precise physiological function of renal alpha-2 adrenoceptors is not yet defined, it is well known thatalpha-2 agonists enhance urine output. Blandford and Smyth (1988, 1989) and Smyth et al. (1992) demonstrated that this effect is mediated in at least two separate sites in the kidney: one is non-AVP dependent, in which urine output is secondary to ...
Chelko SP, Schmiedt CW, Lewis TH, et al. Vasopressin-induced constriction of the isolated rat occipital artery is segment dependent. J Vasc Res. 2013;50(6):478-85. PMID: 24192548.. Mastropaolo M, Zizzo MG, Auteri M, et al. Arginine vasopressin, via activation of post-junctional V1 receptors, induces contractile effects in mouse distal colon. Regul Pept. 2013 Nov 10;187:29-34. PMID: 24185041.. Salazar M, Hu BB, Vazquez J, et al. Exogenous Vasopressin-Induced Hyponatremia in Patients With Vasodilatory Shock: Two Case Reports and Literature Review. J Intensive Care Med. 2013 Oct 7. [Epub ahead of print]. PMID: 24106070. ...
TY - JOUR. T1 - Neurohumoral and cardiopulmonary response to sustained submaximal exercise in the dog. AU - Kirlin, P. C.. AU - Kittleson, Mark D. AU - Johnson, L. E.. PY - 1987. Y1 - 1987. N2 - Neurohumoral, cardiovascular, and respiratory parameters were evaluated during sustained submaximal exercise (3.2 km/h, 15° elevation) in normal adult mongrel dogs. At the level of activity achieved (fivefold elevation of total body O2 consumption and threefold elevation of cardiac output), significant (P , 0.05) increases in plasma norepinephrine and epinephrine concentration (from 150 ± 23 to 341 ± 35 and from 127 ± 27 to 222 ± 31 pg/ml, respectively) were present, as well as smaller but significant increases in plasma renin activity and plasma aldosterone concentration (from 2.2 ± 0.3 to 3.1 ± 0.6 ng·ml-1·h-1 and from 98 ± 8 to 130 ± 6 pg/ml, respectively). Plasma arginine vasopressin increased variably and insignificantly. The cardiovascular response (heart rate, systemic arterial and ...
Argipressin binds to the V1, V2, V3-vascular arginine vasopressin receptor, with a Kd value of 1.31 nM in A7r5 rat aortic smooth muscle cells for V1. Argipressin is a selective V2 agonist. - Mechanism of Action & Protocol.
Vasopressin is a man-made form of a hormone called anti-diuretic hormone that is normally secreted by the pituitary gland. Vasopressin acts on the kidneys and blood vessels. Vasopressin helps prevent loss of water from the body by reducing urine output and helping the kidneys reabsorb water into the body. Vasopressin...
Definition of vasopressins in the Definitions.net dictionary. Meaning of vasopressins. What does vasopressins mean? Information and translations of vasopressins in the most comprehensive dictionary definitions resource on the web.
Vasopressin (also, anti-diuretic hormone (ADH) or arginine vasopressin (AVP)) has been shown to be a very effective vasopressor, especially in circumstances…
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Vasopressin in cardiac surgery. There is limited evidence surrounding the use of vasopressin in cardiac surgery. Anecdotally, we use vasopressin, both during cardiopulmonary bypass and after, when patients have refractory shock. We have no idea what impact this intervention has on outcome. One small (unconvincing) study suggests that the addition of vasopressin is not associated with increased predicted mortality associated with cardiac surgery.27 Specifically, and with scant evidence, vasopressin has been advocated for refractory shock in this setting, especially when there is coexisting pulmonary hypertension.28 In early animal studies, vasopressin was shown to cause pulmonary vasodilation. However, in a well-conducted dog study, vasopressin was shown to cause pulmonary vascular constriction and to exert an important negative inotropic effect on the right ventricle.29 This was not the case when phenylephrine was used to augment systemic BP.29 It may be that at high doses vasopressin causes ...
Severn Biotech, Limited SBP0296 - [Arg8]-Vasopressin - SBP0296 - [Arg8]-Vasopressin AVP MW: 1084.4 H-Cys-Tyr-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2 (Cys1-6, cyclic) Bell, J. et al. (1992) Int. J. Immunopharm. 14, 92. 5mg 25mg
AVPR1B antibody (arginine vasopressin receptor 1B) for IHC-P. Anti-AVPR1B pAb (GTX78015) is tested in Human samples. 100% Ab-Assurance.
AVPR1B antibody (arginine vasopressin receptor 1B) for IHC-P. Anti-AVPR1B pAb (GTX70663) is tested in Human samples. 100% Ab-Assurance.
PMID 25016245] Association between the arginine vasopressin receptor 1A (AVPR1A) gene and preschoolers executive functioning ...
Physiological admeasurement for diagnosing psychiatric disorders. Based on several beastly studies, NMDA receptor - amenable for mediating fast synaptic manual in the axial afraid arrangement (CNS) - can aswell adapt the absolution of arginine vasopressin (AVP) in the bloodstream. By aesthetic AVP absolution in bodies with a alkali solution, it was noticed that the allegation were constant with the above-mentioned beastly studies, i.e., participants challenged by abasement apparent an access in AVP and others grappling with schizophrenia displayed a abatement in AVP.. As of now, the in vivo appraisal of the NMDA receptors in bodies is not a possibility; therefore, the allegation of the abstraction are of abundant value, such that it uses the different blood-based biomarker to appraise the two brainy disorders. The analysis of this access has the abeyant to appraise any basal vulnerabilities of the patients harboring depressive affection or schizophrenia during psychiatric screening. In practice, ...
Tan, H.; Chen, L.; Li, X.; Li, M.; Zhao, M.: A target-driven DNA-based molecular machine for rapid and homogeneous detection of arginine-vasopressin. Analyst 145 (3), pp. 880 - 886 (2020 ...
Vasopressin also called Argipressin (8-L-Arginine Vasopressin) has a molecular weight of 1084.23 Dalton and a molecular formula of C46H65N15O12S2.
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The thing about science is that its always evolving. As we learn more about how the human body works, the things we always held as true may change. Recently, in the media, there have been some claims that cholesterol might not be as bad for you as originally thought. Many are taking this to mean […]. ...
Arginine vasopressin receptor 2 is also expressed in the DCT. Thiazide diuretics inhibit Na+/Cl− reabsorption from the DCT by ...
CRH acts synergistically with arginine vasopressin, angiotensin II, and epinephrine. (In swine, which do not produce arginine ... vasopressin, lysine vasopressin acts synergistically with CRH.) When activated macrophages start to secrete IL-1, which ... "Adrenocorticotropic hormone and cortisol response to corticotropin-releasing factor and lysine vasopressin in pigs". Journal of ...
... correction of bleeding time by 1-desamino-8D-arginine vasopressin". American Journal of Hematology. 30 (3): 154-7. doi:10.1002/ ...
The hypothalamus, in turn, increases the production of vasopressin (ADH, AVP, or arginine vasopressin). These receptors also ... combined with the increased production of vasopressin by the hypothalamus, will cause water retention in urine. This increases ...
... is a Vasopressin 1 agonist, and will thus have effects at all Arginine vasopressin receptor 1As. It will, however, ... "Vasopressin analogues and treatments", Prof Buckingham, Imperial College School of Medicine (ICSM) - adapted by JHPatel. ... Felypressin is a non-catecholamine vasoconstrictor that is chemically related to vasopressin, the posterior pituitary hormone. ...
The vasopressin-like peptides, which differ in positions 3 and/or 8, include AVT and the mammalian hormones arginine ... "AVP arginine vasopressin (neurophysin II, antidiuretic hormone, diabetes insipidus, neurohypophyseal) [ Gallus gallus (chicken ... and lysine vasopressin (isoleucine-3 changed to phenylalanine and arginine-8 changed to lysine). The oxytocin-like peptides, ... glutamine-4 changed to serine and arginine-8 changed to isoleucine); they differ from the vasopressin-like peptides in having a ...
Bisset, G.W., Poisner, A.M. and Smyth, D.G. (1963) Carbamylation of oxytocin and arginine vasopressin. Nature, 199, 69-70. 11. ...
Central diabetes insipidus is caused by low levels of Vasopressin (also called antidiuretic hormone (ADH), arginine vasopressin ... Similar to the inability of control urination, a disruption of arginine vasopressin (ADH) levels has been proposed for nocturia ... ADH replacements such as Desmopressin and Vasopressin Selective Alpha-1 blockers are the most commonly used medicine to treat ...
At about sunset each day, the body releases a minute burst of antidiuretic hormone (also known as arginine vasopressin or AVP ... This ability develops in the same age range as the vasopressin hormone, but is separate from that hormone cycle. The typical ...
Viau, V.; Soriano, L.; Dallman, M (2001). "Androgens alter corticotropin releasing hormone and arginine vasopressin mrna within ... A second physiological response in relation to stress occurs via the vasopressin axis. Vasopressin, also known as antidiuretic ... Vasopressin is released and causes a static increase in blood pressure. This increase in blood pressure under stressful ... There are three important axes, the adrenocorticotropic axis, the vasopressin axis and the thyroxine axis, which are ...
... an orally active arginine vasopressin antagonist with selectivity for V2 receptors". Journal of Medicinal Chemistry. 41 (14): ... The vasopressin receptor antagonists, dubbed vaptans, target the vasopressin hormonal feedback system. Vasopressin, also called ... They work by competing for the active sites on cells meant for vasopressin binding-in this way, the vasopressin is blocked from ... But an excess of vasopressin is counterproductive in a body retaining too much fluid. The drug shows promise in treating heart ...
... , or similar, may refer to: V2 receptor, a protein that acts as receptor for arginine vasopressin Velocity 2, the minimum ...
... vasopressins MeSH D12.644.456.925.100 - argipressin MeSH D12.644.456.925.100.250 - deamino arginine vasopressin MeSH D12.644. ... vasopressins MeSH D12.644.548.691.692.781.100 - argipressin MeSH D12.644.548.691.692.781.100.250 - deamino arginine vasopressin ... vasopressins MeSH D12.644.400.900.050 - argipressin MeSH D12.644.400.900.400 - lypressin MeSH D12.644.400.900.700 - oxytocin ...
Decaux, G; Soupart, A; Vassart, G (2008). "Non-peptide arginine-vasopressin antagonists: the vaptans". Lancet. 371 (9624): 1624 ... A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors. Most commonly ... The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V1A, V1B and V2). These receptors have ... Serradeil-Le Gal, C; Wagnon, J; Valette, G; Garcia, G; Pascal, M; Maffrand, JP; Le Fur, G (2002). Nonpeptide vasopressin ...
... (1-deamino-8-D-arginine vasopressin) is a man-made form of the normal human hormone arginine vasopressin (the ... Compared to vasopressin, desmopressin's first amino acid has been deaminated, and the arginine at the eighth position is in the ... In addition, it has little effect on blood pressure, while vasopressin may cause arterial hypertension. Vasopressin stimulates ... It is a synthetic analogue of vasopressin, the hormone that reduces urine production. Desmopressin was approved for medical use ...
Antidiuretic hormone (ADH or Vasopressin). Arginine vasopressin receptor 1 (V1) on smooth muscle cells Activation of Gq --, ↑ ...
Space-filling model of arginine vasopressin. Estructures disponibles. PDB. Cerca a Ortholog: PDBe, RCSB ... V1A vasopressin receptor binding. • V1B vasopressin receptor binding. • cysteine-type endopeptidase inhibitor activity involved ... Gais S, Sommer M, Fischer S, Perras B, Born J Post-trial administration of vasopressin in humans does not enhance memory ... Strupp BJ, Bunsey M, Bertsche B, Levitsky DA, Kesler M. Enhancement and impairment of memory retrieval by a vasopressin ...
Arginine vasopressin receptor 2. *β-adrenergic receptors types β1, β2 and β3 ...
Two important neuropeptides that mediated pair bond formation were oxytocin and arginine vasopressin (AVP). Even though both ... oxytocin and vasopressin. Other research has implicated nerve growth factor (NGF), a neurotrophin that is fundamental in the ... males and females have both molecules, oxytocin was shown to be predominantly in females and vasopressin predominantly promoted ...
Antidiuretic hormone (or vasopressin, arginine vasopressin). ADH. posterior pituitary. Parvocellular neurosecretory neurons in ...
Dipsogenic DI or primary polydipsia results from excessive intake of fluids as opposed to deficiency of arginine vasopressin. ... Smith D, McKenna K, Moore K, Tormey W, Finucane J, Phillips J, Baylis P, Thompson CJ (2002). "Baroregulation of vasopressin ... Most cases of gestational DI can be treated with desmopressin (ddAVP), but not vasopressin. In rare cases, however, an ... Nephrogenic diabetes insipidus is due to the inability of the kidney to respond normally to vasopressin. ...
Sodium absorption is affected by the release of interleukin-6 as this can cause the secretion of arginine vasopressin which, in ... 2007). "Hyponatremia in marathon runners due to inappropriate arginine vasopressin secretion". The American Journal of Medicine ...
"Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on ... Vasopressin appears to have a similar effect in males.[57] Oxytocin has a role in social behaviors in many species, so it ... Oxytocin and vasopressin were isolated and their total synthesis reported in 1954,[122] work for which Vincent du Vigneaud was ... Oxytocin and vasopressin are the only known hormones released by the human posterior pituitary gland to act at a distance. ...
Antoni FA, Holmes MC, Makara GB, Kárteszi M, László FA (1984). „Evidence that the effects of arginine-8-vasopressin (AVP) on ... A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression". Mol. Psychiatry. 9 ... vasopressin, the first V1b-selective agonist for rat vasopressin/oxytocin receptors". Endocrinology. 148 (9): 4136-46. PMID ... Vasopressin and Oxytocin Receptors: V1B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ...
Antidiuretic hormone (ADH, also known as vasopressin and arginine vasopressin AVP), the majority of which is released from the ... Enhancement by various vasopressin analogs. Neuroendocrinology. 38(5):344-50. *^ Brunton, Laurence L.; Chabner, Bruce A.; ... Central diabetes insipidus caused by a deficiency of vasopressin.. *Gigantism and acromegaly caused by an excess of growth ... Prolactin (PRL), whose release is inconsistently stimulated by hypothalamic TRH, oxytocin, vasopressin, vasoactive intestinal ...
... in the nucleus accumbens and arginine vasopressin (AVP) in the ventral pallidum ... The activities of central oxytocin and ... Central dopamine pathways mediate partner preference behavior, while vasopressin in the ventral pallidum and oxytocin in the ... vasopressin have been associated with both partner preference and attachment behaviours, while dopaminergic pathways have been ...
Chiodera P, Coiro V (May 1990). "Inhibitory effect of ethanol on the arginine vasopressin response to insulin-induced ... Vasopressin levels are reduced after the ingestion of alcohol.[23] The lower levels of vasopressin from the consumption of ... and vasopressin release". Ann. N. Y. Acad. Sci. 625: 249-63. doi:10.1111/j.1749-6632.1991.tb33844.x. PMID 1647726.. ... Early studies showed a link between calcium and the release of vasopressin by the secondary messenger system.[22] ...
"Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on ... Sausville E, Carney D, Battey J (August 1985). "The human vasopressin gene is linked to the oxytocin gene and is selectively ... Landgraf R, Neumann ID (2004). "Vasopressin and oxytocin release within the brain: a dynamic concept of multiple and variable ... Huber D, Veinante P, Stoop R (April 2005). "Vasopressin and oxytocin excite distinct neuronal populations in the central ...
... , also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin,[5] is a hormone synthesized as a ... AVP, ADH, ARVP, AVP-NPII, AVRP, VP, arginine vasopressin, Vasopressin. External IDs. OMIM: 192340 MGI: 88121 HomoloGene: 417 ... Chemical structure of the arginine vasopressin (argipressin) with an arginine at the 8th amino acid position. Lysine ... whereas arginine vasopressin is found in humans.[28] The structure of oxytocin is very similar to that of the vasopressins: It ...
Arginine vasopressin. receptor 2 antagonists amphotericin B, lithium[13][14]. Inhibits vasopressin's action 5. collecting duct ... Selective vasopressin V2 antagonist (sometimes called aquaretics) tolvaptan,[15] conivaptan Competitive vasopressin antagonism ... L. Kovács; B. Lichardus (6 December 2012). Vasopressin: Disturbed Secretion and Its Effects. Springer Science & Business Media ... Alternatively, an antidiuretic, such as vasopressin (antidiuretic hormone), is an agent or drug which reduces the excretion of ...
"Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain ...
Antidiuretic hormone (ADH or Vasopressin). Arginine vasopressin receptor 1 (V1) on smooth muscle cells Activation of Gq --, ↑ ...
Where C is cysteine, G is glycine, R is arginine, and X represents any amino acid.[14] ...
... predominantly lysine and arginine, which are attached on proteins, lipids and nucleic acids.[22] These glycosylation products ... vasopressin (Neurogenic diabetes insipidus). *general (Hypothalamic hamartoma). Pituitary. Hyperpituitarism. *anterior * ...
Vasaipreisin Vasopressin. *Verruculogen. *Vitimíní Vitamins (in general). *Vitimín A Vitamin A(retinol) ... Arginine. *Ascomycin. *Aigéad ascorbach Ascorbic acid (vitamin C). *Asparaigin Asparagine. *Aigéad aspartach Aspartic acid ...
PKA phosphorylates proteins that have the motif Arginine-Arginine-X-Serine exposed, in turn (de)activating the proteins. As ... Vasopressin → V2 receptor. stimulate Na-K-2Cl symporter (perhaps only minor effect)[12]. ... Vasopressin → V2 receptor. stimulate Epithelial sodium channel (perhaps only minor effect)[12]. ...
... and vasopressin deficiency appears to be very rare as a consequence of radiation.[14] ... although a stimulation test with arginine may be used for diagnosis, especially in situations where an insulin tolerance test ...
Alba-Roth J, Müller OA, Schopohl J, von Werder K (December 1988). "Arginine stimulates growth hormone secretion by suppressing ...
Stimulation of the posterior pituitary to release vasopressin (antidiuretic hormone, ADH) also acts on the kidneys to increase ... "Angiotensin-converting enzyme inhibitor-associated angioedema is characterized by a slower degradation of des-arginine(9)- ...
"Linkage relationships of human arginine vasopressin-neurophysin-II and oxytocin-neurophysin-I to prodynorphin and other loci on ... Sausville E, Carney D, Battey J (1985). "The human vasopressin gene is linked to the oxytocin gene and is selectively expressed ... Caldwell HK, Young WS III (2006). "Oxytocin and Vasopressin: Genetics and Behavioral Implications". In Abel L, Lim R (ed.). ... Huber D, Veinante P, Stoop R (2005). "Vasopressin and oxytocin excite distinct neuronal populations in the central amygdala". ...
At the C-terminus Carboxypeptidase E then removes the terminal lysine and arginine residues.[9] The terminal glycine amino acid ... Vasopressin. *See here instead.. VIP/PACAP. VIPR1. *Agonists: Peptide: Bay 55-9837 ...
... and arginine vasopressin (AVP), and down-regulation of adrenal functioning) as well as forebrain serotonergic mechanisms.[21] ...
... in the nucleus accumbens and arginine vasopressin (AVP) in the ventral pallidum ... The activities of central oxytocin and ... vasopressin have been associated with both partner preference and attachment behaviours, while dopaminergic pathways have been ...
Among these conserved amino acids are arginine and phenylalanine residues, which are paired in this family of peptides. Also ... Vasopressin. *See here instead.. VIP/PACAP. VIPR1. *Agonists: Peptide: Bay 55-9837 ... are known as the kisspeptins and belong to a larger family of peptides known as RFamides which all share a common arginine- ...
Desmopressin is used to improve platelet function by activating arginine vasopressin receptor 1A. ...
... and arginine vasopressin (AVP).[20] These hormones travel through the blood vessels to the anterior pituitary gland of the ...
2002). "Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism.". Mol. ... "Vasopressin and Oxytocin Receptors: AVPR1A". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... "The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin.". ... 1999). "Comparison of vasopressin binding sites in human uterine and vascular smooth muscle cells.". Eur. J. Pharmacol. 378 (1 ...
... ,ARUP Laboratories is a national reference laboratory and a worldwide ... Arginine Vasopressin Hormone. 2. Vasopressin (AVP) RIA Test. 3. Vasopressin. 4. Antidiuretic Hormone, Plasma. 5. Antidiuretic ... Arginine Vasopressin (AVP, Antidiuretic Hormone, ADH). Company. ARUP Laboratories. Item. Arginine Vasopressin (AVP, ...
Effect of Arginine Vasopressin on Haemostasis in Chronic Liver Disease. S.H. Saverymuttu, C. Pollard, A. Chitolie, S.S. Nussey ... Effect of Arginine Vasopressin on Haemostasis in Chronic Liver Disease. S.H. Saverymuttu, C. Pollard, A. Chitolie, S.S. Nussey ... Effect of Arginine Vasopressin on Haemostasis in Chronic Liver Disease Message Subject (Your Name) has forwarded a page to you ...
However, there is growing evidence that the oxytocin/vasopressin system can modulate some the effects of MDMA. In this study, ... Taken together, these findings show that the oxytocin/vasopressin system is involved in the rewarding, pro-social and ... alone or in combination with the V1a vasopressin antagonist, SR49059 (0.01-1 ng/kg), before carrying out conditioned place ... alone or in combination with the V1a vasopressin antagonist, SR49059 (0.01-1 ng/kg), before carrying out conditioned place ...
Arginine vasopressin (AVP) is a neuropeptide widely implicated in social behavior. In the extrahypothalamic regions of the ... 2014). Role of arginine vasopressin in modulating plasticity in defensive behavior. Doctoral thesis, Nanyang Technological ...
The pressor actions of ET3 and arginine vasopressin (AVP) were compared with one another in pithed rats in the presence of the ... Comparison between the vasoactive actions of endothelin and arginine vasopressin in pithed rats after pretreatment with BAY K ...
Antonyms for arginine vasopressin hormone. 3 synonyms for antidiuretic hormone: ADH, Pitressin, vasopressin. What are synonyms ... Synonyms for arginine vasopressin hormone in Free Thesaurus. ... redirected from arginine vasopressin hormone). Also found in: ... Arginine vasopressin hormone synonyms, arginine vasopressin hormone antonyms - FreeThesaurus.com https://www.freethesaurus.com/ ... arginine vasopressin hormone provided by ,a style=color:#000 href=https://www.freethesaurus.com/arginine+vasopressin+ ...
8-Arginine Vasopressin (Synthetic). 3. PHARMACEUTICAL FORM. Bulk material (powder) for importation as a biological raw material ... Vasopressin is a potent peripheral vasoconstrictor. Vasopressin has a direct action on the kidney. It also constricts ... Due to rapid inactivation by a number of enzymes that cleave the peptide at several sites, the effects of vasopressin are ... 8-Arginine Vasopressin (Synthetic). 2. QUALITATIVE AND QUANTITATIVE COMPOSITION. ...
Copeptin, a surrogate marker for arginine vasopressin secretion, is positively associated with glucagon. Publikation: Bidrag ... Our data suggest that increased arginine vasopressin-stimulated glucagon secretion might contribute to higher glucagon ... increased arginine vasopressin secretion, in addition to other factors, could further aggravate the hyperglucagonaemic state ... the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon ...
Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model. ... Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model. ... Effects of intravenous arginine vasopressin on epicardial coronary artery cross sectional area in a swine resuscitation model. ... Although arginine vasopressin (AVP) has been shown to be a promising drug during cardiopulmonary resuscitation (CPR), concern ...
Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral ... BackgroundAdministration of arginine vasopressin AVP is associated with reducing jugular venous SjvO2 and regional cerebral ... Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral ... Background anaesthetic agents do not influence the impact of arginine vasopressin on haemodynamic states and cerebral ...
... an Arginine Vasopressin Antagonist.,span,,/span, , Takashi Tsunoda; Akihiro Tanaka; Toshiyasu Mase; Shuichi Sakamoto , download ... A New Synthetic Route to YM087, an Arginine Vasopressin Antagonist.. Takashi Tsunoda; Akihiro Tanaka; Toshiyasu Mase; Shuichi ...
Corticotropin (ACTH), cortisol, arginine vasopressin, prolactin, epinephrine and norepinephrine were quantified in plasma. The ... The hormonal plasma pattern showed increased prolactin during anesthesia and peaks of cortisol, ACTH and arginine vasopressin ...
And some children secrete too little of the hormone (antidiuretic hormone, also called arginine vasopressin) that slows the ...
The antidiuretic hormone arginine vasopressin (AVP) receptors are G protein-coupled receptors which consists of at least three ... Human Recombinant V1B Vasopressin Receptor Stable Cell Line Description. The antidiuretic hormone arginine vasopressin (AVP) ... Catalog Products » Other Products » Stable Cell Lines » Human Recombinant V1B Vasopressin Receptor Stable Cell Line ...
arginine vasopressin receptors (AVP-1B) in rat. Antigen has no significant simililarity with AVP V1a or V2 ...
... of arginine vasopressin antagonists in elucidating the mechanism of action for the behavioral effects of arginine vasopressin. ... L-Arginine, Arg.Vasopressin, Faith. C.S. Mills chmills at flash.net Fri Aug 13 08:59:50 EST 1999 *Previous message: Brain usage ... The interplay of circadian rhythms of arginine vasopressin release, growth hormone release and slow-wave sleep could be ... DeWied and colleagues reviewed numerous studies and concluded that arginine vasopressin may have a physiological role in memory ...
Purpose To evaluate the association between concomitant arginine-vasopressin (AVP)/hydrocortisone therapy and mortality in ... Arginine-vasopressin Hydrocortisone Septic shock Mortality None of the authors has a conflict of interest in regard to the ... Dünser MW, Mayr AJ, Ulmer H, Knotzer H, Sumann G, Pajk W, Friesenecker B, Hasibeder WR (2003) Arginine vasopressin in advanced ... Bauer SR, Lam SW, Ch SS, Oyen LJ (2008) Effect of corticosteroids on arginine vasopressin-containing vasopressor therapy for ...
... Svetlana Beglinger,1 Jürgen Drewe,2 and ... G. Szinnai, N. G. Morgenthaler, K. Berneis et al., "Changes in plasma copeptin, the C-terminal portion of arginine vasopressin ... S. Jochberger, N. G. Morgenthaler, V. D. Mayr et al., "Copeptin and arginine vasopressin concentrations in critically Ill ... the C-terminal vasopressin precursor fragment," Clinical Chemistry, vol. 56, no. 7, pp. 1190-1191, 2010. View at Publisher · ...
... Svetlana Beglinger,1 Jürgen Drewe,2 and ...
View mouse Avpr1b Chr1:131599239-131612000 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
The antidiuretic effect of pneumadin requires a functional arginine vasopressin system.. [J D Watson, D B Jennings, I R Sarda, ... intravenous injection of 20 nmol of pneumadin into non-water-loaded rats caused a significant increase in arginine vasopressin ...
1-desamino-8-D-arginine vasopressin synonyms, 1-desamino-8-D-arginine vasopressin pronunciation, 1-desamino-8-D-arginine ... vasopressin translation, English dictionary definition of 1-desamino-8-D-arginine vasopressin. desmopressin. Translations. ... 1-desamino-8-D-arginine vasopressin - definition of 1-desamino-8-D-arginine vasopressin by The Free Dictionary https://www. ... redirected from 1-desamino-8-D-arginine vasopressin). Also found in: Medical. Translations ...
2010) Arginine-vasopressin and the regulation of aggression in female Syrian hamsters (Mesocricetus auratus). Eur J Neurosci 31 ... Serotonin and arginine-vasopressin mediate sex differences in the regulation of dominance and aggression by the social brain. ... Serotonin and arginine-vasopressin mediate sex differences in the regulation of dominance and aggression by the social brain ... Here, we report that serotonin (5-HT) and arginine-vasopressin (AVP) act in opposite ways within the hypothalamus to regulate ...
1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy. The safety and scientific validity ... 1-deamino 8-d-arginine Vasopressin in Percutaneous Ultrasound-guided Renal Biopsy: a Randomized Controlled Trial. ... 1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy. ... The investigators evaluated the effect of pre-biopsy treatment with 1-deamino-8-D-arginine (DDAVP) on the incidence of post- ...
Arginine Vasopressin 1a Receptor (AVPR1a) RS3 Repeat Polymorphism Associated with Entrepreneurship. 16 Pages Posted: 5 Sep 2012 ... Wernerfelt, Nils and Rand, David G. and Dreber, Anna and Montgomery, Cynthia and Malhotra, Deepak K., Arginine Vasopressin 1a ... the long-repeat genotype of the RS3 microsatellite in the arginine vasopressin 1a receptor promoter region (AVPR1a), the 7- ...
Vasopressins. Arginine Vasopressin. Deamino Arginine Vasopressin. Hemostatics. Coagulants. Vasoconstrictor Agents. Antidiuretic ... 1-deamino 8-d-arginine Vasopressin (DDAVP) in Percutaneous Ultrasound-guided Renal Biopsy. The safety and scientific validity ... 1-deamino 8-d-arginine Vasopressin in Percutaneous Ultrasound-guided Renal Biopsy: a Randomized Controlled Trial. ... The investigators evaluated the effect of pre-biopsy treatment with 1-deamino-8-D-arginine (DDAVP) on the incidence of post- ...
Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor ... arginine vasopressin receptor antagonists; biological activity substituted desloratadine; synthesis; arginine vasopressin ... Synthesis and Biological Evaluation of Substituted Desloratadines as Potent Arginine Vasopressin V2 Receptor Antagonists. Shuai ... Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor ...
... do not play a direct role in arginine-vasopressin release and, therefore, the opposite response of arginine-vasopressin ... The Reflex Control of Arginine-Vasopressin Release in Essential Hypertension B. Ricciardelli B. Ricciardelli ... 2. After 45 min 85° head-up tilt, normal subjects showed an increase in plasma arginine-vasopressin and in plasma renin ... B. Ricciardelli, M. Volpe, B. Trimarco, M. Chiariello, F. Rengo, Mario Condorelli; The Reflex Control of Arginine-Vasopressin ...
Compare and order Arginine Vasopressin Receptor 1B ELISA Kits. View citations, images, detection ranges, sensitivity, prices ... arginine vasopressin receptor 3 , pituitary vasopressin receptor 3 , vasopressin V3 receptor , V3/V1b pituitary vasopressin ... More product categories related to Arginine Vasopressin Receptor 1B ELISA Kit * 153 anti-Arginine Vasopressin Receptor 1B ... pituitary vasotocin receptor , vasopressin V1b receptor , arginine vasopressin receptor 1B , V1A(1) , vasopressin V1b receptor- ...
The arginine vasopressin type-2 antagonist, tolvaptan, is a new-generation diuretic; it is especially indicated in patients ... is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the ... The arginine vasopressin type-2 antagonist, tolvaptan, is a new-generation diuretic; it is especially indicated in patients ... Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal ...
Atrial natriuretic peptide inhibits osmolality-induced arginine vasopressin release in man. M. J. Allen, V. T. Y. Ang, E. D. ... Atrial natriuretic peptide inhibits osmolality-induced arginine vasopressin release in man. M. J. Allen, V. T. Y. Ang, E. D. ... Atrial natriuretic peptide inhibits osmolality-induced arginine vasopressin release in man Message Subject (Your Name) has ... α-hANP produced significant suppression of mean plasma arginine vasopressin over the 60 min after the infusions. ...
What is 1-deamino-8-D-arginine vasopressin? Meaning of 1-deamino-8-D-arginine vasopressin medical term. What does 1-deamino-8-D ... Looking for online definition of 1-deamino-8-D-arginine vasopressin in the Medical Dictionary? 1-deamino-8-D-arginine ... Desmopressin, or 1-deamino-8-D-arginine vasopressin is a synthetic arginine vasopressin analog that increases the levels of ... redirected from 1-deamino-8-D-arginine vasopressin). Also found in: Dictionary. desmopressin acetate (1-deamino-8-D-arginine ...
arginine vasopressin-induced 1. Synonyms: 2310008N12Rik, mVIT32. Gene nomenclature, locus information, and GO, OMIM, and PMID ...
Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats.. G A Rosenberg, O ... Injection of arginine vasopressin into the cerebral ventricles in animals with brain injury increased brain water, whereas ... The arginine vasopressin V1 receptor antagonist and atrial natriuretic peptide significantly (p , 0.05) reduced water and ... Antagonists to arginine vasopressin V1 receptors and atrial natriuretic peptide both significantly reduce hemorrhagic brain ...
... van West, D ... Arginine vasopressin (AVP) influences several symptoms, relevant to affective disorders, notable memory processes, pain ...
Arginine vasopressin infusion is sufficient to model clinical features of preeclampsia in mice. Jeremy A. Sandgren,1 Guorui ... Renal and fetal effects of arginine vasopressin (AVP) and AVP-antagonist coinfusion. (A) Effects of saline (n = 32), AVP (n = ... Gene expression profiling of placentas from dams infused with saline (n = 4) or arginine vasopressin (AVP) (n = 6) dams. (A) ... Gestational arginine vasopressin (AVP) infusion causes an isolated systolic hypertension. Effects of pregnancy and AVP on (A ...
Described here are the results from the profiling of the proteins arginine vasopressin (AVP) and adrenocorticotropic hormone ( ... Kertesz, V., Calligaris, D., Feldman, D.R. et al. Profiling of adrenocorticotropic hormone and arginine vasopressin in human ... Described here are the results from the profiling of the proteins arginine vasopressin (AVP) and adrenocorticotropic hormone ( ... Profiling of adrenocorticotropic hormone and arginine vasopressin in human pituitary gland and tumor thin tissue sections using ...
Arginine-vasopressin (AVP) concentrations in five cortical areas were measured post mortem in nine patients with senile ... Reduction of arginine-vasopressin in the cerebral cortex in Alzheimer type senile dementia. ... Reduction of arginine-vasopressin in the cerebral cortex in Alzheimer type senile dementia. ...
... Resultable. N. pg/mL. XX.X. 3126-0. For questions regarding the Interface Map, please contact ... Arginine Vasopressin Hormone. 3126-0. * Component test codes cannot be used to order tests. The information provided here is ...
2 arginine-vasopressin as radioligand at 0.3 nM in A7r5 cells. ...
Arginine Vasopressin Promoter Regulation Is Mediated by a Neuron-restrictive Silencer Element in Small Cell Lung Cancer. Judy M ... Arginine vasopressin (AVP) is often expressed in small cell lung cancer (SCLC), and a 65-bp AVP minimal promoter fragment is ... Arginine Vasopressin Promoter Regulation Is Mediated by a Neuron-restrictive Silencer Element in Small Cell Lung Cancer ... Arginine Vasopressin Promoter Regulation Is Mediated by a Neuron-restrictive Silencer Element in Small Cell Lung Cancer ...
  • However, there is growing evidence that the oxytocin (OT)/vasopressin system can modulate some the effects of MDMA. (frontiersin.org)
  • And some children secrete too little of the hormone (antidiuretic hormone, also called arginine vasopressin) that slows the production of urine during the night. (sunjournal.com)
  • Aim: To explore the association of plasma copeptin, the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon in obese men and men of normal weight. (regionh.dk)
  • The hormonal plasma pattern showed increased prolactin during anesthesia and peaks of cortisol, ACTH and arginine vasopressin during waking, but no alteration in catecholamine levels. (minervamedica.it)
  • Due to rapid inactivation by a number of enzymes that cleave the peptide at several sites, the effects of vasopressin are relatively short lived unless given by continuous infusions. (imedi.co.uk)
  • Taken together, these findings show that the OT/vasopressin system is involved in the rewarding, prosocial, and anxiolytic effects of MDMA, DOB, and PMA in zebra fish and underline the association between this system and the behavioral alterations associated with disorders related to substance abuse. (frontiersin.org)
  • 2014). Role of arginine vasopressin in modulating plasticity in defensive behavior. (ntu.edu.sg)
  • Arginine vasopressin (AVP) is a neuropeptide widely implicated in social behavior. (ntu.edu.sg)
  • Although arginine vasopressin (AVP) has been shown to be a promising drug during cardiopulmonary resuscitation (CPR), concern has been raised about the potential for AVP-mediated vasoconstriction of the coronary arteries. (elsevier.com)
  • arginine vasopressin receptors (AVP-1B) in rat. (alzforum.org)
  • Antagonists to arginine vasopressin V1 receptors and atrial natriuretic peptide both significantly reduce hemorrhagic brain edema, and atrial natriuretic peptide appears to protect the blood-brain barrier. (ahajournals.org)
  • We study the effects of angiotensin receptors antagonists, arginine vasopressin receptor antagonist, L-arginine and L-NAME, injected into supraoptic nucleus of the hypothalamus (SON) on sodium intake induced by the injection of angiotensin II (ANGII). (scialert.net)
  • Also suggest that both AT 1 and arginine vasopressin V 1 receptors interact with nitrergic pathways within the SON influencing the sodium metabolism by changing sodium appetite induced by ANGII. (scialert.net)
  • A vasopressin receptor antagonist (VRA) is an agent that interferes with action at the vasopressin receptors. (wikipedia.org)
  • The "vaptan" drugs act by directly blocking the action of vasopressin at its receptors (V1A, V1B and V2). (wikipedia.org)
  • Demeclocycline is not a direct antagonist of the vasopressin receptors however, but rather inhibits activation of the intracellular second messenger cascade of this receptor in the kidney by an unknown mechanism. (wikipedia.org)
  • Regulation of arginine vasopressin receptors (Unpublished doctoral thesis). (ucalgary.ca)
  • While experimental data show vasopressin V(1A) receptors to regulate aquaporin (AQP)4 water channel dependent brain water movement, the specific role in vasogenic and cytotoxic edema formation remains unclear. (operativeneurosurgery.com)
  • Kleindienst A, Dunbar JG, Glisson R, Marmarou A. The role of vasopressin V1A receptors in cytotoxic brain edema formation following brain injury. (operativeneurosurgery.com)
  • AVP does this by binding with other vasopressin receptors other than V2R and then stimulating, not the AdC pathway , but the phosphoinositide signaling pathway in IMCD cells . (ndif.org)
  • These receptors may be vasopressin receptors such as V1a, but they also might include oxytocin (OXT) receptors . (ndif.org)
  • Arginine vasopressin has four receptors, each of which are located in different tissues and have specific functions. (worldheritage.org)
  • Vasopressin stimulates a family of arginine vasopressin (AVP) receptors, oxytocin receptors, and purinergic receptors (Russell 2011). (drugs.com)
  • Vasopressin, at pressor doses, also causes smooth muscle contraction in the GI tract by stimulating muscular V1 receptors and release of prolactin and ACTH via AVPR1b (or V3) receptors. (drugs.com)
  • Furthermore, it has been reported that magnocellular arginine vasopressin (AVP) neurones within the PVN express adiponectin receptors. (fujita-hu.ac.jp)
  • Baroreceptor regulation of vasopressin and renin secretion: low-pressure versus high-pressure receptors. (biomedsearch.com)
  • The high-pressure or arterial baroreceptors and low-pressure or atrial receptors are believed to participate in the reflex control of arginine vasopressin (AVP) and renin secretion. (biomedsearch.com)
  • Part I. Arginine vasopressin secretion. (bmj.com)
  • Continuous sequential urinary arginine vasopressin measurements in 14 preterm, ventilated infants suggest that both osmoreceptor and volume receptor systems are able to stimulate the prolonged secretion of arginine vasopressin from 26 weeks' gestation. (bmj.com)
  • The data show that inappropriate arginine vasopressin secretion is common during illness in the first week of life in preterm infants and that strict attention must be paid to water balance during this time. (bmj.com)
  • Unselective (mixed V1A/V2) Conivaptan V1A selective (V1RA) Relcovaptan V1B selective (V3RA) Nelivaptan V2 selective (V2RA) Lixivaptan Mozavaptan Satavaptan Tolvaptan Demeclocycline, a tetracycline antibiotic, is sometimes used to block the action of vasopressin in the kidney in hyponatremia due to inappropriately high secretion of vasopressin (SIADH), when fluid restriction has failed. (wikipedia.org)
  • When the body is dehydrated, more vasopressin is secreted, while secretion is stopped when hydration levels increase. (ccm.net)
  • Effects of oral salt load on arginine-vasopressin secretion in normal subjects. (unicampania.it)
  • Aim: To explore the association of plasma copeptin, the C-terminal portion of provasopressin and a stable surrogate marker for arginine vasopressin secretion, with plasma glucagon in obese men and men of normal weight. (regionh.dk)
  • therefore, increased arginine vasopressin secretion, in addition to other factors, could further aggravate the hyperglucagonaemic state found in obese individuals. (regionh.dk)
  • Abstract Previous blood flow studies demonstrated that arginine vasopressin (AVP) produces exaggerated renal vasoconstriction in young spontaneously hypertensive rats (SHR) compared with Wistar-Kyoto control rats (WKY). (ahajournals.org)
  • Abstract In this study we examined the structural and functional properties of mesenteric resistance arteries isolated from normotensive and hypertensive vasopressin-deficient rats. (ahajournals.org)
  • Methodology/Principal Findings: In a sample of 135 highly accomplished managers, we examine the frequencies of three genotypes: the long-repeat genotype of the RS3 microsatellite in the arginine vasopressin 1a receptor promoter region (AVPR1a), the 7-repeat genotype of the dopamine D4 receptor (DRD4), and the low-activity Monoamine Oxidase A (MAOA) genotype. (ssrn.com)
  • Wernerfelt, Nils and Rand, David G. and Dreber, Anna and Montgomery, Cynthia and Malhotra, Deepak K., Arginine Vasopressin 1a Receptor (AVPR1a) RS3 Repeat Polymorphism Associated with Entrepreneurship (September 4, 2012). (ssrn.com)
  • We examined the extent to which the arginine vasopressin receptor 1a (AVPR1a) and dopamine receptor D4 (DRD4) were related to sensitive maternal behavior directly or indirectly via maternal social cognition. (uncg.edu)
  • The high-density distributions of vasopressin receptor AVPr1a in prairie vole ventral forebrain regions have been shown to facilitate and coordinate reward circuits during partner preference formation, critical for pair bond formation. (wikipedia.org)
  • The arginine vasopressin receptor 1A gene (AVPR1A) is widely expressed in the brain and is considered to be a key receptor for regulation of social behaviour. (cf.ac.uk)
  • The evolution of avpr1a locus, which codes for the vasopressin 1a receptor, has been a major focus of this work. (weebly.com)
  • [3] This interaction takes place as Arginine Vasopressin works with corticotropin releasing hormone to stimulate the pituitary gland to secrete ACTH. (worldheritage.org)
  • Arginine vasopressin V1-antagonist and atrial natriuretic peptide reduce hemorrhagic brain edema in rats. (ahajournals.org)
  • Therefore, to determine the role of endogenous arginine vasopressin in brain edema, we attempted to inhibit edema from a hemorrhagic lesion with an arginine vasopressin V1 receptor antagonist or atrial natriuretic peptide. (ahajournals.org)
  • Adult Sprague-Dawley rats with hemorrhages induced by 0.4 IU bacterial collagenase were treated with 75 ng (n = 9) or 8 micrograms (n = 9) of the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)Arg, 3.2 micrograms (n = 4) atrial natriuretic peptide injected intracerebrally, or 5 micrograms/kg per hour (n = 7) atrial natriuretic peptide intraperitoneally. (ahajournals.org)
  • The V(1A) antagonist SR 49059 offers a new avenue in brain edema treatment and prompts further study into the role of vasopressin following brain injury 1) . (operativeneurosurgery.com)
  • As AVP has long been recognized as a hormone involved in the modulation of HPA axis activity, the aim of this study was to elucidate the role of AVP in acutely heat-exposed rats using Nelivaptan, a selective vasopressin 1b receptor (V1bR) antagonist. (biologists.org)
  • Due to rapid inactivation by a number of enzymes that cleave the peptide at several sites, the effects of vasopressin are relatively short lived unless given by continuous infusions. (imedi.co.uk)
  • [2] AVPR1B is responsible for fueling the effects of vasopressin on ACTH release. (worldheritage.org)
  • Clinical and molecular evidence of abnormal processing and trafficking of the vasopressin preprohormone in a large kindred with familial neurohypophyseal diabetes insipidus due to a signal peptide mutation. (nih.gov)
  • Urine volume ( D ), free water clearance ( C water ), plasma concentrations of arginine vasopressin (AVP), angiotensin II (ANG II) and aldosterone (Aldo), were determined before and three times during the first 4 h after loading. (portlandpress.com)
  • Effects of Nitric Oxide and Arginine Vasopressin on Sodium Intake Induced by Central Angiotensin II. (scialert.net)
  • Objectives The vasoactive peptides arginine vasopressin (AVP) and angiotensin II (Angll) induce similar second messengers in cultured glomerular mesangial cells, as shown by the rise in intracellular calcium and the activation of phospholipases C and A2. (ovid.com)
  • Effect of valsartan on angiotensin II- and vasopressin-degrading activities in the kidney of normotensive and hypertensive rats. (biomedsearch.com)
  • We studied the effect of valsartan on angiotensin II- (GluAP) and vasopressin- (CysAP) degrading activities in the kidney in the rat model of renovascular hypertension, Goldblatt two-kidney one-clip. (biomedsearch.com)
  • Aquaporin-2, a member of the aquaporin family, is an arginine vasopressin-regulated water channel expressed in the renal collecting duct, and a promising marker of the concentrating and diluting ability of the kidney. (mdpi.com)
  • Arginine]vasopressin (AVP) stimulates maximal prostaglandin E2 production in cultured rat renal mesangial cells within 2 min. (uni-regensburg.de)
  • We attempted to clarify the renal physiologic response to arginine vasopressin (AVP) in the 12 sick neonates: three with respiratory distress syndrome (RDS), three with meconium aspiration syndrome, two with transient tachypnea of the newborn, two with neonatal asphyxia, and two low birthweight infants during the first 2 days of life. (meta.org)
  • arginine vasopressin (AVP) produces the water permeability of the renal collecting duct, and its action is mediated by cAMP ( 12 , 15 ). (physiology.org)
  • We previously showed in rat renal glomerular mesangial cells, that arginine vasopressin (AVP)-stimulated cell proliferation was mediated by epidermal growth factor receptor (EGF-R) transactivation, and activation (phosphorylation) of ERK1/2 and p70S6 kinase (Ghosh et al. (elsevier.com)
  • Bolus intravenous injection of 20 nmol of pneumadin into non-water-loaded rats caused a significant increase in arginine vasopressin (AVP) within 10 min. (sigmaaldrich.com)
  • The purpose of this study was to examine the contributions of arginine vasopressin (AVP) and/or hypoxia and reoxygenation (H/R) to the regulation of MCTs and neurotrophic factor in astrocytes obtained from SHRSP/Izm and congenic SHRpch1_18 rats. (biomedcentral.com)
  • This effect was specific for norepinephrine, because responses to arginine vasopressin were similar in vessels isolated from normotensive and hypertensive rats. (ahajournals.org)
  • Indeed, in hypertensive vasopressin-deficient rats responses to acetylcholine were increased in first-order arteries compared with those from normotensive rats. (ahajournals.org)
  • Arginine-vasopressin (AVP) concentrations in five cortical areas were measured post mortem in nine patients with senile dementia of Alzheimer's type (SDAT), and compared with the control group of comparable ages. (bmj.com)
  • Early cytotoxic brain edema component following brain injury plus secondary insult or focal ischemia results from a vasopressin V(1A) receptor mediated response, and occurs most likely through AQP4 up-regulation. (operativeneurosurgery.com)
  • BACKGROUND: Arginine vasopressin (AVP) has been hypothesized to play a role in aetiology of autism based on a demonstrated involvement in the regulation of social behaviours. (cf.ac.uk)
  • Twenty-one non-peptide substituted desloratadine class compounds were synthesized as novel arginine vasopressin receptor antagonists from desloratadine via successive acylation, reduction and acylation reactions. (mdpi.com)
  • Liu, C.-X. Synthesis and Biological Evaluation of Substituted Desloratadines as Potent Arginine Vasopressin V2 Receptor Antagonists. (mdpi.com)
  • 2014. "Synthesis and Biological Evaluation of Substituted Desloratadines as Potent Arginine Vasopressin V2 Receptor Antagonists. (mdpi.com)
  • Polycystin defects increase intracellular cAMP, secondary messenger for vasopressin acting at V2R, leading to cyst development. (wikipedia.org)
  • Vasopressin also increases the concentration of calcium in the collecting duct cells, by episodic release from intracellular stores. (wikipedia.org)
  • The kidney is able to respond to arginine vasopressin stimulation from the first day of life and from 26 weeks' gestation. (bmj.com)
  • Lithium, as lithium carbonate, possesses similar properties to those of demeclocycline on the action of vasopressin in the kidney, and was used clinically before demeclocycline, which largely superseded it for this indication. (wikipedia.org)
  • Vasopressin has a direct action on the kidney. (imedi.co.uk)
  • Background: Vasopressin is elevated in response to heat and dehydration and has been postulated to have a role in the chronic kidney disease of unknown origin (CKDu) being observed in Central America. (cdc.gov)
  • The peptide hormone arginine vasopressin (AVP) plays a critical role in regulating salt and water transport in the mammalian kidney. (bcl-2-protein.com)
  • In this model of anaphylactic shock, early treatment with epinephrine followed by continuous epinephrine or vasopressin infusion resulted in an excellent survival rate, whereas vasopressin only resulted in a 100% death rate. (nih.gov)
  • Data from two consecutive retrospective cohort studies of brain-dead donors who successfully donated organs suggests that the use of intravenous vasopressin given concomitantly with a continuous infusion of insulin (goal blood glucose: 120 to 180 mg/dL), liothyronine, and methylprednisolone may be beneficial for hemodynamically unstable brain-dead donors to increase the quantity and quality of organs available for transplantation [Rosendale 2003a] , [Rosendale 2003b] . (drugs.com)
  • The neuropeptide arginine vasopressin (AVP) is a multifunctional signaling peptide that is highly conserved across eukaryotic animals. (k-state.edu)
  • Arginine vasopressin (AVP) is a neuropeptide widely implicated in social behavior. (ntu.edu.sg)
  • Described here are the results from the profiling of the proteins arginine vasopressin (AVP) and adrenocorticotropic hormone (ACTH) from normal human pituitary gland and pituitary adenoma tissue sections, using a fully automated droplet-based liquid-microjunction surface-sampling-HPLC-ESI-MS-MS system for spatially resolved sampling, HPLC separation, and mass spectrometric detection. (springer.com)
  • Arginine vasopressin is a much more potent stimulus to acth release from ovine anterior pituitary cells than ovine corticotropin-releasing factor: 1. (monash.edu)
  • Cultured rat and ovine anterior pituitary cells were treated with a range of doses (0.01-1,000 nM) of arginine vasopressin (AVP) and ovine corticotropin-releasing factor (CRF), alone or in combination, and medium and cell content of immuno-reactive (ir-)ACTH determined. (monash.edu)
  • The lecture Arginine Vasopressin (AVP) Differential Diagnoses by Carlo Raj, MD is from the course Pituitary Gland Disorders. (lecturio.com)
  • AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary , where it stimulates ACTH release. (worldheritage.org)
  • Thermal stressors such as low and high ambient temperature elicit an abundance of neuroendocrine responses including activation of the hypothalamo-pituitary-adrenal (HPA) axis and arginine vasopressin (AVP) release. (biologists.org)
  • Arginine vasopressin (AVP) is often expressed in small cell lung cancer (SCLC), and a 65-bp AVP minimal promoter fragment is sufficient to restrict activity to SCLC in vitro . (aacrjournals.org)
  • Association of arginine vasopressin (AVP) promoter polymorphisms with preeclampsia. (cdc.gov)
  • The aim of this study was to identify if there is any correlation between arginine vasopressin promoter polymorphisms and PE. (cdc.gov)
  • T allele located at arginine vasopressin receptor 1a receptor promoter rs113481894 locus may be associated with the pathogenesis of type I hepatorenal syndrome. (cdc.gov)
  • Arginine vasopressin, vasopressin, or Anti Diuretic Hormone (ADH) is a peptide hormone which is synthesized in the supraoptoic nucleus of the hypothalamus. (openanesthesia.org)
  • Mavani GP, DeVita MV, Michelis MF (2015) A review of the nonpressor and nonantidiuretic actions of the hormone vasopressin. (springermedizin.de)
  • In contrast, the selective V1a vasopressin - receptor agonist [Phe2,Ile3,Orn8]vasopressin (10 nM) had no effect on vasopressin -stimulated osmotic water permeability . (ndif.org)
  • 1-Desamino 8D Arginine Vasopressin antibody LS-C724524 is a PE-conjugated rabbit polyclonal antibody to 1-Desamino 8D Arginine Vasopressin from human. (lsbio.com)
  • The 2017 American Heart Association (AHA) scientific statement for the Contemporary Management of Cardiogenic Shock recommends vasopressin, if needed, be considered for initial vasoactive management of cardiogenic shock due to right ventricular failure, aortic stenosis, mitral stenosis, or dynamic left ventricular outflow tract (LVOT) obstruction [AHA [van Diepen 2017]] . (drugs.com)
  • Excretion of arginine vasopressin and urine osmolality increased during deterioration of respiratory illness, mask ventilation, bilateral pneumothoraces, and severe intraventricular haemorrhage. (bmj.com)
  • Chen Q, Patel R, Sales A, Oji G, Kim J, Monreal AW, Brinton RD (2000) Vasopressin-induced neurotrophism in cultured neurons of the cerebral cortex: dependency on calcium signaling and protein kinase C activity. (springermedizin.de)
  • Arginine vasopressin (AVP) neurons were preferentially localized in the dorsomedial part of the suprachiasmatic nucleus (SCN). (elsevier.com)
  • The Surviving Sepsis Campaign guidelines recommend vasopressin, if needed, be used in addition to norepinephrine (the preferred first-line, single-agent vasopressor) for the intent of raising mean arterial pressure (MAP) to target or to decrease norepinephrine dosage (Rhodes 2017). (drugs.com)
  • Pressurized arteries were also examined with respect to their responsiveness to the vasoconstrictors norepinephrine and arginine vasopressin and to the endothelium-dependent vasodilator acetylcholine and the endothelium-independent vasodilator papaverine. (ahajournals.org)
  • For the exogenous peptide, see Vasopressin (medication) . (wikipedia.org)
  • The effects of exogenous arginine vasopressin include restoration of MAP and catecholamine vasopressor sparing in septic shock. (elsevier.com)
  • Patients who require exogenous arginine vasopressin, particularly patients with cardiac dysfunction, require vigilant monitoring for signs and symptoms of decreased cardiac output and alterations in tissue perfusion. (elsevier.com)
  • Lee, CS 2006, ' Role of exogenous arginine vasopressin in the management of catecholamine-refractory septic shock ', Critical care nurse , vol. 26, no. 6, pp. 17-23. (elsevier.com)
  • Lee, Christopher S. / Role of exogenous arginine vasopressin in the management of catecholamine-refractory septic shock . (elsevier.com)
  • Arginine vasopressin (AVP) influences several symptoms, relevant to affective disorders, notable memory processes, pain sensitivity, synchronization of biological rhythms and the timing and quality of REM sleep. (diva-portal.org)
  • To date, the major known cause of NDI is either a lack of arginine vasopressin ( AVP ), an inability to respond to AVP , or a lack of aquaporin 2 ( AQP2 ). (ndif.org)
  • Arginine vasopressin (AVP) plays an important role in the expression of aquaporin (AQP-2) in the collecting duct. (physiology.org)
  • 1. The reflex control of arginine-vasopressin release was studied in 12 essential established hypertensive patients and in 12 age-matched normal subjects by comparing the effects of head-up tilt and a variable-pressure neck-chamber. (portlandpress.com)
  • Injection of arginine vasopressin into the cerebral ventricles in animals with brain injury increased brain water, whereas injection of atrial natriuretic peptide reduced water content. (ahajournals.org)
  • Reduction of arginine-vasopressin in the cerebral cortex in Alzheimer type senile dementia. (bmj.com)
  • Use of vasopressin in the treatment of septic shock should be limited to continuous infusions of no more than 0.04 units/min and should be confined to patients with catecholamine-refractory septic shock. (elsevier.com)