Arginine Kinase: An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.Nephropidae: Family of large marine CRUSTACEA, in the order DECAPODA. These are called clawed lobsters because they bear pincers on the first three pairs of legs. The American lobster and Cape lobster in the genus Homarus are commonly used for food.Sea Cucumbers: A class of Echinodermata characterized by long, slender bodies.Creatine Kinase: A transferase that catalyzes formation of PHOSPHOCREATINE from ATP + CREATINE. The reaction stores ATP energy as phosphocreatine. Three cytoplasmic ISOENZYMES have been identified in human tissues: the MM type from SKELETAL MUSCLE, the MB type from myocardial tissue and the BB type from nervous tissue as well as a mitochondrial isoenzyme. Macro-creatine kinase refers to creatine kinase complexed with other serum proteins.Horseshoe Crabs: An arthropod subclass (Xiphosura) comprising the North American (Limulus) and Asiatic (Tachypleus) genera of horseshoe crabs.Echinodermata: A phylum of the most familiar marine invertebrates. Its class Stelleroidea contains two subclasses, the Asteroidea (the STARFISH or sea stars) and the Ophiuroidea (the brittle stars, also called basket stars and serpent stars). There are 1500 described species of STARFISH found throughout the world. The second class, Echinoidea, contains about 950 species of SEA URCHINS, heart urchins, and sand dollars. A third class, Holothuroidea, comprises about 900 echinoderms known as SEA CUCUMBERS. Echinoderms are used extensively in biological research. (From Barnes, Invertebrate Zoology, 5th ed, pp773-826)Phosphotransferases: A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.Silicic Acid: A hydrated form of silicon dioxide. It is commonly used in the manufacture of TOOTHPASTES and as a stationary phase for CHROMATOGRAPHY.Octopodiformes: A superorder in the class CEPHALOPODA, consisting of the orders Octopoda (octopus) with over 200 species and Vampyromorpha with a single species. The latter is a phylogenetic relic but holds the key to the origins of Octopoda.Phosphatidylinositol 3-Kinases: Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.MAP Kinase Signaling System: An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.Protein Kinases: A family of enzymes that catalyze the conversion of ATP and a protein to ADP and a phosphoprotein.Protein-Serine-Threonine Kinases: A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.Arginine: An essential amino acid that is physiologically active in the L-form.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Optical Rotatory Dispersion: The method of measuring the dispersion of an optically active molecule to determine the relative magnitude of right- or left-handed components and sometimes structural features of the molecule.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Brachyura: An infraorder of chiefly marine, largely carnivorous CRUSTACEA, in the order DECAPODA, including the genera Cancer, Uca, and Callinectes.Mollusca: A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora.Phosphotransferases (Nitrogenous Group Acceptor): A group of enzymes that catalyzes the transfer of a phosphate group onto a nitrogenous group acceptor. EC 2.7.3.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.Calcium-Calmodulin-Dependent Protein Kinases: A CALMODULIN-dependent enzyme that catalyzes the phosphorylation of proteins. This enzyme is also sometimes dependent on CALCIUM. A wide range of proteins can act as acceptor, including VIMENTIN; SYNAPSINS; GLYCOGEN SYNTHASE; MYOSIN LIGHT CHAINS; and the MICROTUBULE-ASSOCIATED PROTEINS. (From Enzyme Nomenclature, 1992, p277)Kinetics: The rate dynamics in chemical or physical systems.Arginine Vasopressin: The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.src-Family Kinases: A PROTEIN-TYROSINE KINASE family that was originally identified by homology to the Rous sarcoma virus ONCOGENE PROTEIN PP60(V-SRC). They interact with a variety of cell-surface receptors and participate in intracellular signal transduction pathways. Oncogenic forms of src-family kinases can occur through altered regulation or expression of the endogenous protein and by virally encoded src (v-src) genes.Substrate Specificity: A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.Bivalvia: A class in the phylum MOLLUSCA comprised of mussels; clams; OYSTERS; COCKLES; and SCALLOPS. They are characterized by a bilaterally symmetrical hinged shell and a muscular foot used for burrowing and anchoring.Protein Kinase C: An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.Organophosphorus Compounds: Organic compounds that contain phosphorus as an integral part of the molecule. Included under this heading is broad array of synthetic compounds that are used as PESTICIDES and DRUGS.Sequence Homology, Amino Acid: The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.p38 Mitogen-Activated Protein Kinases: A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.Cyclic AMP-Dependent Protein Kinases: A group of enzymes that are dependent on CYCLIC AMP and catalyze the phosphorylation of SERINE or THREONINE residues on proteins. Included under this category are two cyclic-AMP-dependent protein kinase subtypes, each of which is defined by its subunit composition.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Databases, Protein: Databases containing information about PROTEINS such as AMINO ACID SEQUENCE; PROTEIN CONFORMATION; and other properties.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Proteins: Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.Sequence Analysis, Protein: A process that includes the determination of AMINO ACID SEQUENCE of a protein (or peptide, oligopeptide or peptide fragment) and the information analysis of the sequence.Holothuria: A genus of large SEA CUCUMBERS in the family Holothuriidae possessing thick body walls, a warty body surface, and microscopic ossicles.Exchange Transfusion, Whole Blood: Repetitive withdrawal of small amounts of blood and replacement with donor blood until a large proportion of the blood volume has been exchanged. Used in treatment of fetal erythroblastosis, hepatic coma, sickle cell anemia, disseminated intravascular coagulation, septicemia, burns, thrombotic thrombopenic purpura, and fulminant malaria.Vascular Endothelial Growth Factor A: The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.Prostatectomy: Complete or partial surgical removal of the prostate. Three primary approaches are commonly employed: suprapubic - removal through an incision above the pubis and through the urinary bladder; retropubic - as for suprapubic but without entering the urinary bladder; and transurethral (TRANSURETHRAL RESECTION OF PROSTATE).Prostatic Neoplasms: Tumors or cancer of the PROSTATE.Prostate: A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.RNA Splicing: The ultimate exclusion of nonsense sequences or intervening sequences (introns) before the final RNA transcript is sent to the cytoplasm.RNA-Binding Proteins: Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.Prostate-Specific Antigen: A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.A Kinase Anchor Proteins: A structurally-diverse family of intracellular-signaling adaptor proteins that selectively tether specific protein kinase A subtypes to distinct subcellular sites. They play a role in focusing the PROTEIN KINASE A activity toward relevant substrates. Over fifty members of this family exist, most of which bind specifically to regulatory subunits of CYCLIC AMP-DEPENDENT PROTEIN KINASE TYPE II such as CAMP PROTEIN KINASE RIIALPHA or CAMP PROTEIN KINASE RIIBETA.Cyclic AMP-Dependent Protein Kinase Type II: A cyclic AMP-dependent protein kinase subtype primarily found in particulate subcellular fractions. They are tetrameric proteins that contain two catalytic subunits and two type II-specific regulatory subunits.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.

O-Crystallin, arginine kinase and ferritin from the octopus lens. (1/75)

Three proteins have been identified in the eye lens of the octopus, Octopus dofleini. A 22 kDa protein comprising 3-5% of the soluble protein of the lens is 35-43% identical to a family of phosphatidylethanolamine-binding proteins of vertebrates. Other members of this family include the immunodominant antigen of the filarial parasite, Onchocerca volvulus, putative odorant-binding proteins of Drosophila and a protein with unknown function of Caenorhabditis elegans. We have called this protein O-crystallin on the basis of its abundance in the transparent lens. O-Crystallin mRNA was detected only in the lens. Two tryptic peptides of another octopus lens protein, less abundant than O-crystallin, showed 80% identity to arginine kinase of invertebrates, a relative of creatine kinase of vertebrates. Finally, ferritin cDNA was isolated as an abundant cDNA from the octopus lens library. Northern blots showed that ferritin mRNA is not lens-specific.  (+info)

Arginine kinase evolved twice: evidence that echinoderm arginine kinase originated from creatine kinase. (2/75)

Arginine kinase (AK) was isolated from the longitudinal muscle of the sea cucumber Stichopus japonicus. Unlike the monomeric 40 kDa AKs from molluscs and arthropods, but like the cytoplasmic isoenzymes of vertebrate creatine kinase (CK), the Stichopus enzyme was dimeric. To explore the evolutionary origin of the dimeric AK, we determined its cDNA-derived amino acid sequence of 370 residues. A comparison of the sequence with those of other enzymes belonging to the phosphagen kinase family indicated that the entire amino acid sequence of Stichopus AK is apparently much more similar to vertebrate CKs than to all other AKs. A phylogenetic tree also strongly suggests that the Stichopus AK has evolved from CK. These results support the conclusion that AK evolved at least twice during the evolution of phosphagen kinases: first at an early stage of phosphagen kinase evolution (its descendants are molluscan and arthropod AKs) and secondly from CK later in metazoan evolution. A comparison of the amino acid sequence around the guanidino specificity (GS) region (which is a possible candidate for the guanidine substrate recognition site in the phosphagen kinase family) of the Stichopus enzyme with those of other phosphagen kinases showed that the GS region of the Stichopus enzyme was of the AK type: five amino acid deletions in the flexible loop region that might help to accommodate larger guanidine substrates in the active site. The presence of the AK-type deletions in the Stichopus AK, even though it seems that the enzyme's most immediate ancestor was probably CK, strongly suggests that the GS region has a role in substrate specificity. Stichopus AK and presumably other echinoderm AKs seem to have evolved from the CK gene; the sequence of GS region might have been replaced by the AK type via exon shuffling. The presence of an intron near the GS region in the Stichopus AK gene supports this hypothesis.  (+info)

Thermodynamics of the arginine kinase reaction. (3/75)

The effect of temperature, pH, free [Mg(2+)], and ionic strength on the apparent equilibrium constant of arginine kinase (EC 2.7.3.3) was determined. At equilibrium, the apparent K' was defined as [see text] where each reactant represents the sum of all the ionic and metal complex species. The K' at pH 7.0, 1.0 mM free [Mg(2+)], and 0. 25 M ionic strength was 29.91 +/- 0.59, 33.44 +/- 0.46, 35.44 +/- 0. 71, 39.64 +/- 0.74, and 45.19 +/- 0.65 (n = 8) at 40, 33, 25, 15, and 5 degrees C, respectively. The standard apparent enthalpy (DeltaH degrees') is -8.19 kJ mol(-1), and the corresponding standard apparent entropy of the reaction (DeltaS degrees') is + 2. 2 J K(-1)mol(-1) in the direction of ATP formation at pH 7.0, free [Mg(2+)] =1.0 mM, ionic strength (I) =0.25 M at 25 degrees C. We further show that the magnitude of transformed Gibbs energy (DeltaG degrees ') of -8.89 kJ mol(-1) is mostly comprised of the enthalpy of the reaction, with 7.4% coming from the entropy TDeltaS degrees' term (+0.66 kJ mol(-1)). Our results are discussed in relation to the thermodynamic properties of its evolutionary successor, creatine kinase.  (+info)

Trypanosoma cruzi arginine kinase characterization and cloning. A novel energetic pathway in protozoan parasites. (4/75)

This work contains the first description of a guanidino kinase in a flagellar unicellular parasite. The enzyme phosphorylates L-arginine and was characterized in preparations from Trypanosoma cruzi, the ethiological agent of Chagas' disease. The activity requires ATP and a divalent cation. Under standard assay conditions (1 mM L-arginine), the presence of 5-fold higher concentrations of canavanine or histidine produced a greater than 50% enzyme inhibition. The base sequence of this enzyme revealed an open reading frame of 357 amino acids and a molecular weight of 40,201. The amino acid sequence shows all of the characteristic consensus blocks of the ATP:guanidino phosphotransferase family and a putative "actinin-type" actin-binding domain. The highest amino acid identities of the T. cruzi sequence, about 70%, were with arginine kinases from Arthropoda. Southern and chromosome blots revealed that the kinase is encoded by a single-copy gene. Moreover, Northern blot analysis showed an mRNA subpopulation of about 2.0 kilobases, and Western blotting of T. cruzi-soluble polypeptides revealed a 40-kDa band. The finding in the parasite of a phosphagen and its biosynthetic pathway, which are totally different from those in mammalian host tissues, points out this arginine kinase as a possible chemotherapy target for Chagas' disease.  (+info)

Induced fit in arginine kinase. (5/75)

Creatine kinase (CK) and arginine kinase (AK) are related enzymes that reversibly transfer a phosphoryl group between a guanidino compound and ADP. In the buffering of ATP energy levels, they are central to energy metabolism and have been paradigms of classical enzymology. Comparison of the open substrate-free structure of CK and the closed substrate-bound structure of AK reveals differences that are consistent with prior biophysical evidence of substrate-induced conformational changes. Large and small domains undergo a hinged 13 degrees rotation. Several loops become ordered and adopt different positions in the presence of substrate, including one (residues 309-319) that moves 15 A to fold over the substrates. The conformational changes appear to be necessary in aligning the two substrates for catalysis, in configuring the active site only when productive phosphoryl transfer is possible, and excluding water from the active site to avoid wasteful ATP hydrolysis.  (+info)

Noninvasive measurement of gene expression in skeletal muscle. (6/75)

We have developed a noninvasive detection method for expression of viral-mediated gene transfer. A recombinant adenovirus was constructed by using the gene for arginine kinase (AK), which is the invertebrate correlate to the vertebrate ATP-buffering enzyme, creatine kinase. Gene expression was noninvasively monitored using (31)P-magnetic resonance spectroscopy ((31)P-MRS). The product of the AK enzyme, phosphoarginine (PArg), served as an MRS-visible reporter of AK expression. The recombinant adenovirus coding for arginine kinase (rAdCMVAK) was injected into the right hindlimbs of neonatal mice. Two weeks after injection of rAdCMVAK, a unique (31)P-MRS resonance was observed. It was observable in all rAdCMVAK injected hindlimbs and was not present in the contralateral control or the vehicle injected limb. PArg and phosphocreatine (PCr) concentrations were calculated to be 11.6 +/- 0.90 and 13.6 +/- 1.1 mM respectively in rAdCMVAK injected limbs. AK activity was demonstrated in vivo by monitoring the decreases in PArg and ATP resonances during prolonged ischemia. After 1 h of ischemia intracellular pH was 6.73 +/- 0.06, PCr/ATP was decreased by 77 +/- 8%, whereas PArg/ATP was decreased by 50 +/- 15% of basal levels. PArg and PCr returned to basal levels within 5 min of the restoration of blood flow. AK activity persisted for at least 8 mo after injection, indicating that adenoviral-mediated gene transfer can produce stable expression for long periods of time. Therefore, the cDNA encoding AK provides a useful reporter gene that allows noninvasive and repeated monitoring of gene expression after viral mediated gene transfer to muscle.  (+info)

Arginine kinase from Nautilus pompilius, a living fossil. Site-directed mutagenesis studies on the role of amino acid residues in the Guanidino specificity region. (7/75)

Arginine kinases were isolated from the cephalopods Nautilus pompilius, Octopus vulgaris, and Sepioteuthis lessoniana, and the cDNA-derived amino acid sequences have been determined. Although the origin and evolution of cephalopods have long been obscure, this work provides the first molecular evidence for the phylogenetic position of Cephalopoda in molluscan evolution. A crystal structure for Limulus arginine kinase showed that four amino acid residues (Ser(63), Gly(64), Val(65), and Tyr(68)) are hydrogen-bonded with the substrate arginine. We introduced three independent mutations, Ser(63) --> Gly, Ser(63) --> Thr, and Tyr(68) --> Ser, in Nautilus arginine kinase. One of the mutants had a considerably reduced substrate affinity, accompanied by a decreased V(max). In other mutants, the activity was lost almost completely. It is known that substantial conformational changes take place upon substrate binding in arginine kinase. We hypothesize that the hydrogen bond between Asp(62) and Arg(193) stabilizes the closed, substrate-bound state. Site-directed mutagenesis studies strongly support this hypothesis. The mutant (Asp(62) --> Gly or Arg(193) --> Gly), which destabilizes the maintenance of the closed state and/or perhaps disrupts the unique topology of the catalytic pocket, showed only a very weak activity (0.6-1.5% to the wild-type).  (+info)

Expression of arginine kinase enzymatic activity and mRNA in gills of the euryhaline crabs Carcinus maenas and Callinectes sapidus. (8/75)

Phosphagen kinases catalyze the reversible dephosphorylation of guanidino phosphagens such as phosphocreatine and phosphoarginine, contributing to the restoration of adenosine triphosphate concentrations in cells experiencing high and variable demands on their reserves of high-energy phosphates. The major invertebrate phosphagen kinase, arginine kinase, is expressed in the gills of two species of euryhaline crabs, the blue crab Callinectes sapidus and the shore crab Carcinus maenas, in which energy-requiring functions include monovalent ion transport, acid-base balance, nitrogen excretion and gas exchange. The enzymatic activity of arginine kinase approximately doubles in the ion-transporting gills of C. sapidus, a strong osmoregulator, when the crabs are transferred from high to low salinity, but does not change in C. maenas, a more modest osmoregulator. Amplification and sequencing of arginine kinase cDNA from both species, accomplished by reverse transcription of gill mRNA and the polymerase chain reaction, revealed an open reading frame coding for a 357-amino-acid protein. The predicted amino acid sequences showed a minimum of 75 % identity with arginine kinase sequences of other arthropods. Ten of the 11 amino acid residues believed to participate in arginine binding are completely conserved among the arthropod sequences analyzed. An estimation of arginine kinase mRNA abundance indicated that acclimation salinity has no effect on arginine kinase gene transcription. Thus, the observed enhancement of enzyme activity in C. sapidus probably results from altered translation rates or direct activation of pre-existing enzyme protein.  (+info)

Phosphagen (guanidino) kinases, including creatine kinase (CK), arginine kinase (AK), taurocyamine kinase (TK), lombricine kinase (LK), glycocyamine kinase (GK), and hypotaurocyamine kinase (HTK), are enzymes that catalyze the reversible transfer of the γ-phosphoryl group of adenosine triphosphate (ATP) to naturally occuring guanidino compounds such as creatine, arginine, yelding adenosine diphosphate (ADP) and a phosphorylated guanidine typically referred to as phosphagen (phosphocreatine, phosphoarginine and etc). Members of this enzyme family play a key role in animals as ATP-buffering systems in cells that display high and variable rates of ATP turnover. Phosphagen kinases have been found in all animal species and in some protozoa, such as trypanosomes, choanoflagellates, and the ciliates, Paramecium tetraurelia, Paramecium caudatum, and Tetrahymena. Eukaryotic phosphagen kinases consist of a small, ~100-residue, α-helical N-terminal domain and a larger, 250+-residue, C-terminal α/β ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
p23 is a member of the p24 family of proteins. (A) cDNA-derived amino acid sequence of the BHKp23 precursor. The predicted cleavage site for the signal peptid
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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
1. Both the monomer arginine kinase from lobster muscle and the dimer arginine kinase from Holothuria forskali catalyse the ATP-ADP partial exchange reaction at rates equal to 3 and 0.6% of the normal rate of transphosphorylation respectively. The Mg2+-nucleotide complex is the substrate for this as it is for the kinase reaction. 2. Analogues of arginine inhibit the exchange reaction of the lobster enzyme but enhance that of the Holothuria enzyme. 3. With the lobster enzyme NO3- has no effect on the exchange reaction alone and inhibit only slightly the apparent enhancement of the exchange reaction produced by the addition of arginine. This is compatible with previous findings for this enzyme that formation of the anion-stabilized dead-end complex, enzyme-arginine-MgADP-NO3-, does not occur to any marked degree. 4. About 80% of the ADP-ATP exchange reaction of the lobster enzyme remains after inhibition with iodoacetamide. This is further decreased to 65% by the addition of L-arginine, indicating ...
Get information, facts, and pictures about phosphagen at Encyclopedia.com. Make research projects and school reports about phosphagen easy with credible articles from our FREE, online encyclopedia and dictionary.
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
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Arginine kinase (AK), an important member of the phosphokinase family, is involved in temporal and spatial adenosine triphosphate (ATP) buffering systems. AK plays an important role in physiological function and metabolic regulations, in particular tissues with high and fluctuating energy demands. In present study, four AK genes were firstly identified from Yesso scallop (Patinopecten yessoensis) genome, respectively named PyAK1-4. PyAKs have highly conserved structures with a six-exon/five-exon structure, except for PyAK3. PyAK3 contains an unusual two-domain structure and a "bridge intron" between the two domains, which may originate from gene duplication and subsequent fusion. Phylogenetic analysis showed that all PyAKs belonged to an AK supercluster together with other AK proteins from Mollusca, Platyhelminthes, Arthropoda, and Nematode. A transcriptome database demonstrated that PyAK3 and PyAK4 were the main functional executors with high expression level during larval development and in ...
Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008 ...
The American cockroach was introduced to the United States from Africa as early as 1625. They belong to the Kingdom: Animalia, Phylum: Arthropoda, Class: Insecta (Insecta: Blattodea: Blattidae), Order: Dictyoptera, and Family: Blattidae. Its common name is American cockroach and scientific name is Periplaneta Americana (Linnaeus). American cockroaches are normally between one and one and a half inches in length. They are oval shaped and reddish-brow with yellow fringes on the area of the body behind the head as adults. They hide in dark crevices during the day, which could include: sewer and drainage systems, cracks and crevices of a house, steam tunnels, large institutional buildings and basements. They emerge at night to hunt for food. Theyll eat pretty much anything. Although it prefers sweets, they have been observed eating paper, boots, hair, bread, fruit, book bindings, fish, peanuts, old rice, putrid sake, the soft part on the inside of animal hides, cloth and dead insects. American ...
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Ornithine carbamoyltransferase (OTC) catalyzes the reversible transfer of the carbamoyl group from carbamoyl phosphate (CP) to the Nε atom of L-ornithine (ORN) to produce L-citrulline. There are two types of the enzyme - anabolic (aOTC) and catabolic (cOTC). Anabolic OTCs participate in the urea cycle and L-arginine biosynthesis. Catabolic OTCs are part of the catabolic arginine deiminase pathway found in a number of microorganisms. The reported structure is for the anabolic enzyme from pathogen Vibrio vulnificus. The structure has three monomers in the asymmetric unit which form the physiologically active trimer. One of the three enzyme subunits is entrapped in a complex with its first substrate carbamoyl phosphate and its inhibitor arginine. That complex provides additional structural insights into mechanism of inhibition by arginine. It shows that binding of CP together with arginine causes closure of interdomain cleft and brings catalytic loops K*STRTR, B2-H3 and SMG into the catalytic site ...
Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.
Aspartate transaminase (AST) or aspartate aminotransferase, also known as AspAT/ASAT/AAT or serum glutamic oxaloacetic transaminase (SGOT), is a pyridoxal phosphate (PLP)-dependent transaminase enzyme (EC 2.6.1.1) that was first described by Arthur Karmen and colleagues in 1954. AST catalyzes the reversible transfer of an α-amino group between aspartate and glutamate and, as such, is an important enzyme in amino acid metabolism. AST is found in the liver, heart, skeletal muscle, kidneys, brain, and red blood cells. Serum AST level, serum ALT (alanine transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels. Aspartate transaminase catalyzes the interconversion of aspartate and α-ketoglutarate to oxaloacetate and glutamate. Aspartate (Asp) + α-ketoglutarate ↔ oxaloacetate + glutamate (Glu) As a prototypical transaminase, AST relies on PLP (Vitamin B6) as a cofactor to transfer the amino group from ...
To enable the resolution of deep phylogenetic divergence in Scolytinae and closely related weevils, several new molecular markers were screened for their phylogenetic potential. The nuclear protein encoding genes, CAD and Arginine Kinase, were particularly promising and will be added to future phylogenetic studies in combination with 28S, COI, and Elongation Factor 1α. The combined analysis of multiple molecular markers and wide taxon sampling is expected to resolve many previously unresolved nodes in scolytine phylogeny, but a completely resolved topology seems dependent on the inclusion of a large number of morphological characters. A well founded phylogeny will provide a powerful framework for testing evolutionary hypotheses on habitat selection and reproductive biology. ...
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Evidence has been presented for the possible transport function of conjugated roach plasma proteins during molting. Extensive changes in these proteins are evident during the premolt stage. The remainder of the instar appears to be devoted to a gradu
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Arginine: | | | Arginine | | | | ||| ... World Heritage Encyclopedia, the aggregation of the largest online encyclopedias available, and the most definitive collection ever assembled.
Arginine is one of the compounds responsible for helping blood vessels contract and expand, helping to control blood flow. Most people get all the arginine they need by eating a healthy...
Suurepärane arginiini allikas. See aitab Sind kasvatada lihasmassi ja vabaneda rasvast. Suurendab lämmastikoksiidide taset organiismis, mis omakorda märgatavalt suurendab verevoolu ja hapniku vedamist iga rakule. Mega Arginine stimuleerib immuunsüsteem...
Blue crabs Callinectes sapidus Rathbun, 1896 support large commercial and recreational fisheries along the Atlantic coast and in the Gulf of Mexico (GOM). Female blue crabs are traditionally believed to produce one to six broods in their lifetime. However, recent evidence has shown that females have the ability to spawn up to eight broods in a single spawning season, with as many as 18 broods over their lifespan. In this study, fecundity and egg diameter were examined by brood class (primiparous, multiparous) in the spring and summer/fall. Mean carapace width of females was significantly different between brood class and season, with the largest females in the spring. There was a positive relationship between fecundity and carapace width. Although primiparous spring females were the most fecund (3.2 ± 1.5 million eggs), no statistically significant differences in fecundity by brood class and season were found. Loss of eggs occurred during embryonic development; primiparous females lost ~0.9 million
General aspects of the life history of the blue crab (Callinectes sapidus Rathbun) were described in the early part of the 20th century, but the larval biology of the species has remained enigmatic until recently. In the waters off the Mid-Atlantic States (MAB), spawning occurs throughout the summer with a peak in late July and early August. Gravid females migrate to the mouths of estuaries, and newly hatched larvae are quickly exported to the adjacent shelf. Development through seven zoea stages takes place in the open waters of the continental shelf and requires 4 to 5 weeks. Zoea larvae remain in surface waters, but not necessarily in the neuston, throughout development. Retention in the MAB is controlled by wind-driven, northward-flowing water located between 20 and 60 km off the coast. This northward current is between a strong, southward coastal current that hugs the immediate shoreline and a more diffuse southward flow along the outer continental shelf. Re-invasion of the estuaries of the ...
TY - JOUR. T1 - Oxidative modification and aggregation of creatine kinase from aged mouse skeletal muscle.. AU - Nuss, Jonathan E.. AU - Amaning, James K.. AU - Bailey, C. Eric. AU - DeFord, James H.. AU - Dimayuga, Vincent L.. AU - Rabek, Jeffrey P.. AU - Papaconstantinou, John. PY - 2009/6/1. Y1 - 2009/6/1. N2 - Creatine kinase catalyzes the reversible transfer of the gamma phosphate from ATP to creatine forming the high energy compound creatine phosphate. Muscle creatine kinase (CKm) activity maintains energetic homeostasis as variations in energy requirements dictate that ATP be readily available. Recent studies suggest that CKm activity is altered during aging. Proteomic analyses have shown that CKm is 3-nitrotyrosine (3-NT) modified and carbonylated in aged rodent skeletal muscle. However, it remains unknown if these modifications affect its structure and activity. To address this we characterized oxidatively modified CKm from the quadriceps of young, middle-aged, and aged mice. Our data ...
Ornithine carbamoyltransferase (OTC) catalyzes the reversible transfer of the carbamoyl group from carbamoyl phosphate (CP) to the Nε atom of L-ornithine (ORN) to produce L-citrulline. There are two types of the enzyme - anabolic (aOTC) and catabolic (cOTC). Anabolic OTCs participate in the urea cycle and L-arginine biosynthesis. Catabolic OTCs are part of the catabolic arginine deiminase pathway found in a number of microorganisms. The reported structure is for the anabolic enzyme from pathogen Vibrio vulnificus. The structure has three monomers in the asymmetric unit which form the physiologically active trimer. Two of the three enzyme subunits are entrapped in a complex with its first substrate carbamoyl phosphate. That complex provides additional structural insights in the enzyme mechanism of action because it proves that binding of CP causes closure of interdomain cleft and change of 55-60 catalytic loop conformation, whereas catalytic loops B2-H3 and SMG can adopt conformations different ...
Le genre Corbicula peut être observé dans un large éventail dhabitats limniques depuis les eaux douces lotiques, des rivières et des fleuves, ou lentiques, des lacs et des étangs, jusquaux eaux saumâtres des estuaires et des lagons. Les espèces du genre Corbicula vivent sur une grande variété de substrats comme les fonds constitués de limon, dargile, de sable ou de gravier[58]. À lexception de Corbicula japonica préférant les eaux saumâtres des estuaires[22], la majorité des espèces préfèrent les eaux douces bien quelles puissent tolérer des salinités jusquà 24 ppt[59] et sacclimater aussi aux eaux saumâtres. Le genre Corbicula peut être observé dans des eaux dont la gamme de température sétend de 2 à 30 °C[60] mais les basses températures limitent la reproduction, lexpulsion des jeunes ne pouvant avoir lieu quau-delà de 16 °C[61]. Le genre Corbicula préfère les eaux vives riches en oxygène dissout[62] et où le renouvellement de lapport en nourriture ...
Protein turnover is a tightly controlled process that is crucial for the removal of aberrant polypeptides and for cellular signalling. Whereas ubiquitin marks eukaryotic proteins for proteasomal degradation, a general tagging system for the equivalent bacterial Clp proteases is not known. Here we describe the targeting mechanism of the ClpC-ClpP proteolytic complex from Bacillus subtilis. Quantitative affinity proteomics using a ClpP-trapping mutant show that proteins phosphorylated on arginine residues are selectively targeted to ClpC-ClpP. In vitro reconstitution experiments demonstrate that arginine phosphorylation by the McsB kinase is required and sufficient for the degradation of substrate proteins. The docking site for phosphoarginine is located in the amino-terminal domain of the ClpC ATPase, as resolved at high resolution in a co-crystal structure. Together, our data demonstrate that phosphoarginine functions as a bona fide degradation tag for the ClpC-ClpP protease. This system, which is
What is creatine?. Creatine is an amino acid derivative constructed from arginine, glycine and methionine. It is produced naturally by the body in the kidneys, liver, and pancreas at a rate of about 1-2 grams/day. Creatine can also be obtained from food (particularly red meat) and supplementation.. The uptake of creatine into muscle cells is an active process. 90-95% of creatine in the body is found in muscle.. Creatine is degraded into creatinine and excreted in the urine at a rate of around 2 grams/day.. Why is creatine so important?. The energy needs of brief, rapid and powerful movements lasting fewer than 10 seconds, such as a short sprint, are met by the phosphagen system. This system quickly replenishes the stores of adenosine triphosphate, or ATP, which provides energy to the working cells. Muscles have an existing amount of ATP hanging around ready for action, but only a little bit - enough for a few seconds. ATP is broken down by removing a phosphate, which turns it into adenosine ...
1CZE: Cocrystallization of a mutant aspartate aminotransferase with a C5-dicarboxylic substrate analog: structural comparison with the enzyme-C4-dicarboxylic analog complex.
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To know about L Arginine - L-arginine is an amino acid necessary for the body to make proteins. L-arginine can be found in the red meat, fish, chicken.
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This study was designed to determine the presence and distribution of the carbohydrate binding proteins in Callinectes sapidus serum and hemocytes, describe them by biochemical and serological characteristics, and attempt to obtain insight into their biological role. C. sapidus serum and the microsomal preparation isolated from disrupted hemocytes agglutinated a panel of untreated and enzyme-treated vertebrate erythrocytes and cultured lymphoid cell lines. Crossed absorption experiments suggested the presence of multiple specific lectins in serum. The microsomal preparation showed a 3S-fold increase in specific activity when compared to the hemocyte lysate suggesting that hemocyte lectins are membrane-associated. Agglutination by serum and hemocyte lectins was inhibited by low concentrations of N-acylamino compounds including sialic acid (NeuAc), N-acetylmuramic acid, GlcNAc, and ManNAc. Hemagglutination by lectins of both serum and hemocyte microsomal preparation required divalent cations as ...
This study was designed to determine the presence and distribution of the carbohydrate binding proteins in Callinectes sapidus serum and hemocytes, describe them by biochemical and serological characteristics, and attempt to obtain insight into their biological role. C. sapidus serum and the microsomal preparation isolated from disrupted hemocytes agglutinated a panel of untreated and enzyme-treated vertebrate erythrocytes and cultured lymphoid cell lines. Crossed absorption experiments suggested the presence of multiple specific lectins in serum. The microsomal preparation showed a 3S-fold increase in specific activity when compared to the hemocyte lysate suggesting that hemocyte lectins are membrane-associated. Agglutination by serum and hemocyte lectins was inhibited by low concentrations of N-acylamino compounds including sialic acid (NeuAc), N-acetylmuramic acid, GlcNAc, and ManNAc. Hemagglutination by lectins of both serum and hemocyte microsomal preparation required divalent cations as ...
Abedin, Md. Zainul and Karim, Alias A. and Latiff, Aishah A. and Gan, Chee-Yuen and Che Ghazali, Farid and Zzaman, Wahidu and Hossain, Md. Murad and Ahmed, Faiyaz and Absar, Nurul and Sarker, Md. Zaidul Islam (2013) Physicochemical and biochemical properties of pepsin-solubilized collagen isolated from the integument of Sea Cucumber (Stichopus vastus). Journal of Food Processing and Preservation. XX-XX. ISSN 0145-8892 (In Press) Zainul Abedin, Md and A Karim, Alias and Ahmed, Faiyaz and A Latiff, Aishah and Chee-Yuen, Gan and Che Ghazali, Farid and Sarker, Md. Zaidul Islam (2012) Isolation and characterization of pepsin-solubilized collagen from the integument of sea cucumber (Stichopus vastus). Journal of the Science of Food and Agriculture. ISSN 1097-0010 (Online) ...
Creatine, which is synthesized while in the liver and kidneys, is transported in the blood and taken up by tissues with substantial Electrical power calls for, like the Mind and skeletal muscle, by an active transportation technique. The concentration of ATP in skeletal muscle is generally two-5 mM, which might cause a muscle contraction of only some seconds.[13] Fortunately, through instances of amplified Strength demands, the phosphagen (or ATP/PCr) process quickly resynthesizes ATP from ADP with the usage of phosphocreatine (PCr) through a reversible reaction with the enzyme creatine kinase (CK ...
Energy Systems & Exercise: The Basics ATP Aerobic System Lactic Acid/Anaerobic Glycolysis ATP-PC (phosphagen) 0 sec 4 sec sec min min + Strength - Power: power lift, shot put, golf swing Sustained Power: sprints, fast breaks, football Anaerobic Power - Endurance: m dash, 100 m swim Aerobic Endurance: Beyond 800 m run Immediate/short-term Aerobic-oxidative non-oxidative systems system
Anaerobic interval training is probably best described as "repeated maximal sprint training" or "supramaximal sprint training." It takes various forms and has vastly different training effects depending upon the intensity and duration of the work and the duration of the rest period. Consequently, there is little consensus in the literature with many studies varying too many factors, which obscure the actual mechanisms being used. Much of this form of training aims to improve anaerobic function, particularly glycogenolysis, but aerobic contributions and adaptations are also involved. Fixed Work-rate Intervals. With short bouts (10-30 seconds) of intense exercise (150+% of vVO2max), it is the duration of the rest period that determines the energy systems employed. When very short rests (1:1 work:rest 10-15 seconds) are used, the adaptation is primarily aerobic. When rest periods exceed 30 seconds, the length of time it takes to allow the phosphagen pool to be resynthesized after very short maximum ...
Item #: SCP-1953. Object Class: Safe. Special Containment Procedures: Instances of SCP-1953 may be kept in a standard containment locker at Site 20. Individuals infected with SCP-1953-1 are to be housed in a secure containment cell at Bio-Research Area-17.. Description: SCP-1953 is the collective designation of 26 objects commonly found in bedrooms, such as pillows, blankets, stuffed animals and alarm clocks. SCP-1953-1 refers to an unknown number of bipedal beings measuring 4 cm on average and resembling Periplaneta americana (American cockroach) which appear when a human subject enters REM sleep within 5 meters of an instance of SCP-1953. Evidence suggests instances of SCP-1953-1 are capable of reading and understanding spoken English, but so far have not responded to attempts to communicate.. When such an event occurs, instances of SCP-1953-1 will search for any surrounding human subjects and attempt to enter their mouths. SCP-1953 instances exhibit an unexplained ability to calm living human ...
SWISS-MODEL Repository entry for A1AKS6 (RIBB_PELPD), 3,4-dihydroxy-2-butanone 4-phosphate synthase. Pelobacter propionicus (strain DSM 2379 / NBRC 103807 / OttBd1)
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Brief blurbs about recent arthropod news and research: The blue crab, Callinectes sapidus, has been found in England for the second time ever. These ill-tempered, but delicious, swimming crabs are native to North America; where they represent a major marine fishery despite serious conservation concerns. Previously, blue crabs have turned up in Japan and the…
The parasitic dinoflagellate Hematodinium perezi is highly prevalent in juvenile blue crabs, Callinectes sapidus, along the eastern seaboard of the USA. Although the parasite is known to kill adult crabs, the mortality rate of naturally infected juvenile crabs remains unknown. We analyzed the influence of temperature and salinity on the mortality of recently recruited blue crab that were naturally infected with H. perezi. Over 492 juvenile crabs (infected, n=282; uninfected controls, n=210) were held individually in six-well plates and held at six temperatures (4, 10, 15, 20, 25, and 30 °C) or three salinities (5, 15, and 30 psu) for a maximum of 90 days ...
Free Online Library: Extensive heteroplasmy and evidence for fragmentation in the Callinectes sapidus mitochondrial genome.(Report) by Journal of Shellfish Research; Zoology and wildlife conservation Biological sciences Blue crab Genetic aspects Natural history Blue crabs Genomes Analysis Genomics Mitochondria
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A Japanese study offers a hint why American cockroaches are so hard to get rid of: Females can breed for years and multiply their numbers dozens of times alone, without ever mating with a male.
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The catecholamines norepinephrine and epinephrine regulate important physiological functions in vertebrates. In insects; these neuroactive substances are functionally replaced by the phenolamines octopamine and tyramine. Phenolamines activate specific guanine nucleotide-binding (G) protein-coupled receptors (GPCRs). Type 1 tyramine receptors are better activated by tyramine than by octopamine. In contrast; type 2 tyramine receptors are almost exclusively activated by tyramine. Functionally; activation of type 1 tyramine receptors leads to a decrease in the intracellular concentration of cAMP ([cAMP]i) whereas type 2 tyramine receptors can mediate Ca2+ signals or both Ca2+ signals and effects on [cAMP]i. Here; we report that the American cockroach (Periplaneta americana) expresses a second type 1 tyramine receptor (PeaTAR1B) in addition to PeaTAR1A (previously called PeaTYR1). When heterologously expressed in flpTM cells; activation of PeaTAR1B by tyramine leads to a concentration-dependent decrease in
We collected 60 mature fully intact female Callinectes sapidus (carapace width = 12.5 - 16.5 cm) using baited crab traps from the National Estuarine Research Reserve, North Inlet (33°20N, 79°10W, Georgetown, South Carolina). Crabs were obtained during early May 2014 over the course of a week, one month prior to the peak spawning season. We started the experiment in blocks (5 total) as crabs were captured so that no crabs were held longer than 24 hours before commencing the study and being fed.. Crabs were transported to the Baruch Institute wet lab (situated on North Inlet) where they were placed into individual plastic containers (length 29.8 cm, width 19.7 cm, height 20.3 cm) submersed within seven flow-through tanks supplied with seawater directly from North Inlet. Water temperature matched environmental conditions and varied between 25.4 - 34.5 °C throughout the experiment. Individual containers were filled with a 1.5 cm layer of sediment collected from the field and continuously ...
Creatine is a principle component of the creatine kinase (CK) phosphagen system common to all vertebrates. It is found in excitable cells, such as cardiomyocytes, where it plays an important role in the buffering and transport of chemical energy to ensure that supply meets the dynamic demands of the heart. Multiple components of the CK system, including intracellular creatine levels, are reduced in heart failure, while ischaemia and hypoxia represent acute crises of energy provision. Elevation of myocardial creatine levels has therefore been suggested as potentially beneficial, however, achieving this goal is not trivial. This mini-review outlines the evidence in support of creatine elevation and critically examines the pharmacological approaches that are currently available. In particular, dietary creatine-supplementation does not sufficiently elevate creatine levels in the heart due to subsequent down-regulation of the plasma membrane creatine transporter (CrT). Attempts to increase passive diffusion
What is Arginine?. The amino acid Arginine (l-Arginine HCl) is acquiring a reputation for keeping the bodys biggest muscle, the heart, in tip-top shape. In addition to the heart, Arginine can also needed to increase protein synthesis which can in turn increase cels. Studies have found that men with low sperm counts experienced an increase in the number of sperm when they were supplemented with Arginine. How does it work?. Arginine supplements appear to reduce mildly elevated blood pressure by enhancing the synthesis of Nitric Oxide (a gas) in the cells lining the blood vessels. This helps dilate vessel walls and improves blood flow around the heart. In fact, Nitric Oxide ranks as the bodys most potent blood vessel expander. In addition, Arginine may help in treating male fertility caused by circulation problems. Where does it come from?. Arginine is an amino acid found in many foods, including dairy products, meat, poultry, fish, nuts and chocolate. Safety / Side Effects. Arginine has so far ...
Pengalaman dari konsumen-konsumen Gold-G Sea Cucumber yang tersebar di berbagai wilayah di Indonesia, mereka dapat terbantu dari penyakit : Jantung koroner, asam urat, diabetes melitus, kolesterol, gula darah, hepatitis, hipertensi, lupus, maag (lambung), jerawat, luka-luka, luka bakar, radang paru-paru, tipus, tumor, stroke, epilepsi, asma, dan lain-lain.. baca juga : obat untuk tuntaskan epilepsi. Keampuhan teripang mengatasi penyakit jantung diduga lantaran kandungan asam docosahexanat (DHA) pada teripang. Asupan DHA-asam lemak utama pada sperma, otak, dan retina mata-tinggi dapat menurunkan trigliserida darah penyebab penyakit jantung.. artikel lainnya : obat herbal jantung bocor paling laris. Itu telah dibuktikan Prof Zaiton Hassan, peneliti dari Departemen Ilmu Pangan, Universitas Putra Malaysia, Malaysia. Bersama M. A Kaswandi, dari Universitas Kebangsaan Malaysia, ia meneliti kandungan asam lemak teripang Stichopus chloronotus. Hasilnya: kandungan DHA teripang relatif tinggi, yaitu ...
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They have been found to be an important source of allergies in people. So, we should eliminate these cockroaches by using different techniques. One way is to use baits and boric acid to eliminate your cockroach problem ...
Periplaneta japonica: Biologists identify a species of cockroach in New York City that can reportedly survive a winter there, according to a report released Monday. The newcomer is from Asia. Might it evict its American cousin?
Arginine is used in sports nutrition to increase blood flow. However, all arginine supplements may not be equal. A recent study suggests that inositol-stabilized arginine may be more bioavailable than arginine hydrochloride. Participants in the study included 10 healthy men, half of whom were given inositol-stabilized
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Posted by guillo from IP 68.100.129.210 on March 25, 2013 at 17:22:23:. Though Arginine and Histidine are syntethized inssufitiently in the organism, should we consider them ...
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Arginelle - When the aphthae themselves are used, as was the case with us, there is a great deal of spontaneus infection which also lasts longer than that obtained from intact boils.
Abstract: The ecdysial suture is the region on an arthropod exoskeleton that splits to allow the animal to escape from its old carapace. To understand why this region preferentially splits, I examined the morphology and composition of the intermolt and premolt suture of the blue crab, Callinectes sapidus, using light and scanning electron microscopy (SEM). No differences were detected between the suture and the adjacent cuticle with the general dyes acridine orange, hematoxylin and eosin, toluidine blue, periodic acid Schiff or paraldehyde fuchsin. Only three of 22 FITC-labeled lectins differentiated the suture. Lens culinaris agglutinin, Vicia faba agglutinin, and Pisum sativum agglutinin, which have an affinity for fucosylated a-N-acetylglucosamine with mannose dendrimers, bound more intensely to the exocuticle of the suture and less intensely to the endocuticle of the suture. The suture had no setae, and was paralleled by a knobbed ridge. The suture was thinner than the surrounding cuticle, ...
GAINESVILLE, Fla. - A researcher at the University of Florida Institute of Food and Agricultural Sciences wants to study the blue crab and a viral pathogen that infects it. Now, a nearly $1 million grant from the National Science Foundation will help Donald Behringer and colleagues study the disease along the entire western Atlantic seaboard.. In Florida, several disasters-including hurricanes in 2004, 2005, and 2008, and the Deepwater Horizon oil spill in 2010-have impacted the blue crab population, the Florida Fish and Wildlife Conservation Commission states. The virus has also added to the decline of blue crab. According to the Gulf States Fisheries Commission, by 2013 blue crab harvest totaled 46.5 million pounds with dockside revenue of $61.3 million. This is down from a peak of 70 million pounds through 2000.. "The blue crab is found from Maine to Argentina and is heavily fished through most of this range," said Behringer, associate professor with a joint appointment in the UF/IFAS School ...
American Cockroach Control - Austin, TX Not many people are aware that there are different species of cockroaches found in the Austin area, and Magic Pest
Weis, J.S. 2012. Walking Sideways The Remarkable World of Crabs. Cornell University Press.. Weis, J.S., and A. Candelmo. 2012. Pollutants and fish predator/prey behavior: A review of laboratory field approaches. Current Zoology 58: 9-20.. Weis, J.S., Bergey, L., Reichmuth, J., and A. Candelmo. 2011. Living in a Contaminated Estaury: Behavioral Changes and Ecological Consequences for Five Species. Bioscience 61: 375-385.. Weis, J.S. 2011. Invasion and predation in aquatic ecosystems. Current Zoology 57: 613-624.. Reichmuth, J.M., MacDonald, J., Ramirez, J., and J.S. Weis. 2011. Fight or flight: an investigation of aggressive behavior and predator avoidance in two populations of blue crabs (Callinectes sapidus Rathbun) in New Jersey. Hydrologia 658: 173-182. Burridge, L., J.S. Weis, F. Cabello, J. Pizarro and K. Bostick. 2010. Chemical use in salmon aquaculture: A review of current practices and possible environmental effects. Aquaculture 306: 7-23.. Candelmo, A., A. Deshpande, B. Dockum, P. Weis ...
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Get information, facts, and pictures about arginine at Encyclopedia.com. Make research projects and school reports about arginine easy with credible articles from our FREE, online encyclopedia and dictionary.
Arginine is considered a miracle amino acid due to its many uses and benefits. From reducing the risk of heart diseases to enhancing the immune system, the immense pharmaceutical value and benefits of arginine have been proven time and again by multiple research. It continues to be a wonder amino acid that offers so many. ...
On this page about Arginine Hydrochloride (Phebra) you will find information relating to side effects, age restrictions, food interactions, whether the medicine is available at a government subsidised price on the pharmaceutical benefits scheme (PBS) as well as other useful information.
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Terpenoids, also known as isoprenoids, are a large class of natural products consisting of isoprene (C5) units. There are two biosynthetic pathways, the mevalonate pathway [MD:M00095] and the non-mevalonate pathway or the MEP/DOXP pathway [MD:M00096], for the terpenoid building blocks: isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). The action of prenyltransferases then generates higher-order building blocks: geranyl diphosphate (GPP), farsenyl diphosphate (FPP), and geranylgeranyl diphosphate (GGPP), which are the precursors of monoterpenoids (C10), sesquiterpenoids (C15), and diterpenoids (C20), respectively. Condensation of these building blocks gives rise to the precursors of sterols (C30) and carotenoids (C40). The MEP/DOXP pathway is absent in higher animals and fungi, but in green plants the MEP/DOXP and mevalonate pathways co-exist in separate cellular compartments. The MEP/DOXP pathway, operating in the plastids, is responsible for the formation of essential oil ...
l arginine l citrulline powder Manufacturers & l arginine l citrulline powder Suppliers Directory - choose l arginine l citrulline powder from 158 l arginine l citrulline powder Super Suppliers of China.
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
I have some questions about taking arginine. I am going to start taking L-arginine tomorrow but I have doubt related to a comment I read in this forum. A member says arginine is very bad for mental acuity. Are there anyone who experienced something like that ? Considering the good effects on blood vessels , I think it must be beneficial for brain too. But am I thinking so simple? Are there different factors ? It is very important for me please write your comments. Other question, I read people here takes 5 g a day. In my country there are only 500 mg capsules and it offers only 1 capsule a day in prospectus. Do I have to take 10 capsules a day ? Why this much dose? Doesnt it work if I take 500mg a day ...
Support for Healthy Cardiovascular Function. Arginine Plus delivers high quality L-arginine with calcium L-5-methyltetrahydrofolate.
Arginine +H2N=C(NH2)-NH-(CH2)3- Glutamate → Glutamate-5-semialdehyde (γ-glutamyl kinase) → Arginine ... Glutamic Acid → Glutamate-5-semialdehyde → Proline (γ-glutamyl kinase) Phenylalanine§. Ph-CH2- Phosphoenolpyruvate → 2-keto-3- ... Methylation often occurs to arginine or lysine and involves adding a methyl group to a nitrogen (replacing a hydrogen). The R ... Methylation reduces the ability of these amino acids to form hydrogen bonds so arginine and lysine that are methylated have ...
Zinovieva, R.; Piatigorsky, J.; Tomarev, S. I. (1999). "O-Crystallin, arginine kinase and ferritin from the octopus lens". ...
Ghosh G, Adams JA (February 2011). "Phosphorylation mechanism and structure of serine-arginine protein kinases". The FEBS ... Two protein kinases are thought to play a role in the localization of SR proteins in the nucleus. SR protein kinase 1 (SRPK1) ... Eight unphosphorylated repeats of arginine and serine in the RS domain take a helical form with arginine on the outside to ... Methylation of arginine residues in the RRM may also contribute to the export of SR proteins out of the nucleus. SR proteins ...
... has the ability to catabolize arginine. Three enzymes are involved in the process; including arginine ... deaminase (ADI), ornithine carbamoyltransferase (OTC), and carbamate kinase (CK). A fourth protein located at the cell membrane ... acts as transporter, allowing the antiporter exchange between arginine and ornithine. A probiotic organism such as ...
... was found to interact with SRPK1 (Serine/arginine- rich protein-specific kinase 1). The interaction was detected via a ... protein kinase assay. SRPK1 localizes to the nucleus and the cytoplasm. By regulating intracellular localization of splicing ...
Arginine phosphorylation by McsB kinase marks proteins for degradation by a Clp protease. The arginine phosphorylation system, ... Cyclin-dependent kinases (CDKs) are serine-threonine kinases which regulate progression through the eukaryotic cell cycle. CDKs ... Most phosphorylation is carried out by a single superfamily of protein kinases that share a conserved kinase domain. Protein ... Phosphorylation of Src tyrosine kinase (pronounced "sarc") by Csk (C-terminal Src kinase) inactivates Src by inducing a ...
Jarilla B. R., Uda K., Suzuki T., Acosta L. P., Urabe M. & Agatsuma T. (2014). "Characterization of arginine kinase from the ...
Arginine kinase (EC 2.7.3.3), which catalyses the transfer of phosphate from ATP to arginine. Taurocyamine kinase (EC 2.7.3.4 ... Strong SJ, Ellington WR (January 1995). "Isolation and sequence analysis of the gene for arginine kinase from the chelicerate ... Lombricine kinase (EC 2.7.3.5), an annelid-specific enzyme that catalyses the transfer of phosphate from ATP to lombricine. ... Creatine kinase (EC 2.7.3.2) (CK), which catalyses the reversible transfer of high energy phosphate from ATP to creatine, ...
This gene encodes a serine/arginine protein kinase specific for the SR (serine/arginine-rich domain) family of splicing factors ... Mylonis I, Giannakouros T (2003). "Protein kinase CK2 phosphorylates and activates the SR protein-specific kinase 1". Biochem. ... "Serine-arginine protein kinase 1 (SRPK1) inhibition as a potential novel targeted therapeutic strategy in prostate cancer". ... "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. ...
"The cellular localization of the murine serine/arginine-rich protein kinase CLK2 is regulated by serine 141 autophosphorylation ... Dual specificity protein kinase CLK2 is an enzyme that in humans is encoded by the CLK2 gene. This gene encodes a member of the ... This protein kinase is involved in the regulation of several cellular processes and may serve as a link between cell cycle ... "Entrez Gene: CLK2 CDC-like kinase 2". Human CLK2 genome location and CLK2 gene details page in the UCSC Genome Browser. Lee K, ...
1993). "Identification of an snRNP-associated kinase activity that phosphorylates arginine/serine rich domains typical of ... Cao W, Garcia-Blanco MA (1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient for ASF/ ... Cao W, Garcia-Blanco MA (August 1998). "A serine/arginine-rich domain in the human U1 70k protein is necessary and sufficient ... "Human autoimmune sera as molecular probes for the identification of an autoantigen kinase signaling pathway". J. Exp. Med. 196 ...
2007). "Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved ...
"SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. ... "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". J. Biol. ... Dual specificity protein kinase CLK1 is an enzyme that in humans is encoded by the CLK1 gene. This gene encodes a member of the ... "Entrez Gene: CLK1 CDC-like kinase 1". Colwill K, Feng LL, Yeakley JM, Gish GD, Cáceres JF, Pawson T, Fu XD (Oct 1996). " ...
This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent ... kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs ... Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene. Pre-mRNA splicing ... 2002). "Mammalian PRP4 Kinase Copurifies and Interacts with Components of Both the U5 snRNP and the N-CoR Deacetylase Complexes ...
"Non-arginine-aspartate (non-RD) kinases are associated with innate immune receptors that recognize conserved microbial ... NODs transduce signals in the pathway of NF-κB and MAP kinases via the serine-threonine kinase called RIP2. NODs signal via N- ... Some IRAK and RIP family kinases fall into a small functional class of kinases termed non-RD, many of which do not ... revealed that despite the small number of non-RD kinases in these genomes (9%-29%), 12 of 15 kinases known or predicted to ...
There was a high level of arginine kinase and certain other enzymes in the adductor muscles which was indicative of the ... conversion of arginine phosphate for energy production. Up to 23% of the ATP used for energy transfer was supplied in this way ... the energy for swimming was supplied aerobically through respiration with little input from anaerobic glycolysis and arginine ...
SRPK2 is a Serine/arginine rich protein-specific kinase which specifically phosphorylates its substrates at serine residues ... non-kinase and kinase specific), and sumoylation. There is also one leucine-rich nuclear export signal. The entire secondary ... serine/threonine-protein kinase 2) SRPK2 (serine/threonine-protein kinase 2) Function Jenkins D, Beales PL, Wilkie AO (May 2012 ... Preduces neural network predictions of kinase specific eukaryotic protein phosphoylation sites Kinase-specific Phosphorylation ...
Afadin AFAP-110 Affixin Aginactin AIP1 Aldolase Angiogenin Anilin Annexins Aplyronine Archvillin Arginine kinase Arp2/3 complex ... p21-activated Kinase) Plectin p47PHOX Parvin (actopaxin) Prefoldin p53 PASK (Proline, Alanine rich Ste20 related Kinase) ... Myosin light chain kinase MAL Mip-90 Myosin Light Chain A1 MARKS MIM MAYP Mycalolide (a macroglide drug) Mayven Myelin basic ... actin regulating kinase) Radixin (the R of ERM proteins) Rapsyn Rhizopodin RPL45 RTX toxin (Vibrio cholerae) RVS 167 Sac6 Sla1p ...
... has been shown to interact with: CDK9, Cyclin-dependent kinase 7, HTATSF1, PIN1, POLR2A, PRMT1 and Protein arginine ... phosphorylates hSPT5 and RNA polymerase II carboxyl-terminal domain independently of cyclin-dependent kinase-activating kinase ...
PKA phosphorylates proteins that have the motif Arginine-Arginine-X-Serine exposed, in turn (de)activating the proteins. As ... out of 540 different protein kinase genes that make up for human kinome, only one other protein kinase, Casein kinase 2, is ... "cAMP-dependent protein kinase" redirects here. It is not to be confused with AMP-activated protein kinase or cyclin-dependent ... The dimerization and docking (D/D) domain of the dimer binds to the A-kinase binding (AKB) domain of A-kinase anchor protein ( ...
This enzyme is also called glycocyamine kinase. This enzyme participates in arginine and proline metabolism. HOBSON GE, REES KR ... Guanidinoacetate kinase belongs to the family of transferases, specifically those that transfer phosphorus-containing groups ( ... In enzymology, a guanidinoacetate kinase (EC 2.7.3.1) is an enzyme that catalyzes the chemical reaction ATP + guanidinoacetate ...
Asparagine, histidine, and arginine residues are involved in catalysis. Human PanK-II isoforms PanK1α, PanK1β, PanK2, and PanK3 ... The regulation of pantothenate kinase is essential to controlling the intracellular CoA concentration. Pantothenate kinase is ... Pantothenate kinase at the US National Library of Medicine Medical Subject Headings (MeSH) EC 2.7.1.33 Robishaw, J. D.; Berkich ... Pantothenate kinase (EC 2.7.1.33, PanK; CoaA) is the first enzyme in the Coenzyme A (CoA) biosynthetic pathway. It ...
Farago A, Denes G (1967). "Mechanism of arginine biosynthesis in Chlamydomonas reinhardti. II Purification and properties of N- ... In enzymology, an acetylglutamate kinase (EC 2.7.2.8) is an enzyme that catalyzes the chemical reaction: ATP + N-acetyl-L- ... N-acetylglutamate kinase, and N-acetylglutamic 5-phosphotransferase. As of late 2007, 9 structures have been solved for this ... repressible enzymes of arginine synthesis in Escherichia coli". Biochem. Biophys. Res. Commun. 7: 491-6. doi:10.1016/0006-291X( ...
In enzymology, an arginine kinase (EC 2.7.3.3) is an enzyme that catalyzes the chemical reaction ATP + L-arginine ⇌ {\ ... L-arginine N-phosphotransferasel ATP:L-arginine, and ω-N-phosphotransferase. This enzyme participates in arginine and proline ... The systematic name of this enzyme class is ATP:L-arginine Nω-phosphotransferase. Other names in common use include arginine ... the two substrates of this enzyme are ATP and L-arginine, whereas its two products are ADP and Nω-phospho-L-arginine. This ...
"Structural and catalytic role of arginine 88 in Escherichia coli adenylate kinase as evidenced by chemical modification and ... Adenylate kinase, subfamily InterPro: IPR006259 UMP-CMP kinase InterPro: IPR006266 Adenylate kinase, isozyme 1 InterPro: ... adenylate kinase performed dual enzymatic functions. ADK complements nucleoside diphosphate kinase deficiency. Adenylate kinase ... Lu Q, Inouye M (June 1996). "Adenylate kinase complements nucleoside diphosphate kinase deficiency in nucleotide metabolism". ...
This enzyme participates in 4 metabolic pathways: purine metabolism, glutamate metabolism, arginine and proline metabolism, and ... In enzymology, a carbamate kinase (EC 2.7.2.2) is an enzyme that catalyzes the chemical reaction ATP + NH3 + CO2 ⇌ {\ ... Bishop SH, Grisolia S (1966). "Crystalline carbamate kinase". Biochim. Biophys. Acta. 118 (1): 211-5. doi:10.1016/s0926-6593(66 ... Glasziou KT (1956). "The metabolism of arginine in Serratia marcescens. II Carbamyladenosine diphosphate phosphoferase". Aust. ...
NAD(P)+:arginine ADP-ribosyltransferase *Pertussis toxin. *Cholera toxin. *Poly ADP ribose polymerase ...
ASF/SF2 controls the splicing of various tumor suppressor genes, kinases, and kinase receptors, all of which have the potential ... "SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors". The Journal ... "Structurally unique yeast and mammalian serine-arginine protein kinases catalyze evolutionarily conserved phosphorylation ... Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 ...
Arginine kinase (EC:2.7.3.3*Search proteins in UniProtKB for this EC number. ... sp,O15992,KARG_ANTJA Arginine kinase OS=Anthopleura japonica OX=67755 PE=1 SV=1 ... PS51510 PHOSPHAGEN_KINASE_C, 2 hits. PS51509 PHOSPHAGEN_KINASE_N, 2 hits. ... PS51510 PHOSPHAGEN_KINASE_C, 2 hits. PS51509 PHOSPHAGEN_KINASE_N, 2 hits. ...
Arginine kinase (EC:2.7.3.3*Search proteins in UniProtKB for this EC number. ... sp,Q9GYX1,KARG_PACMR Arginine kinase OS=Pachygrapsus marmoratus OX=135190 PE=2 SV=1 ... PS51510 PHOSPHAGEN_KINASE_C, 1 hit. PS51509 PHOSPHAGEN_KINASE_N, 1 hit. ... PS51510 PHOSPHAGEN_KINASE_C, 1 hit. PS51509 PHOSPHAGEN_KINASE_N, 1 hit. ...
The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Arginine kinase (AK), a homologue of creatine kinase, catalyses the reversible transfer of a phosphoryl group between a ... Critical initial real-space refinement in the structure determination of arginine kinase.. Zhou G1, Somasundaram T, Blanc E, ... The family of phosphagen kinases eluded structure determination for over 25 years until an inactive form creatine kinase (CK) ...
In enzymology, an arginine kinase (EC 2.7.3.3) is an enzyme that catalyzes the chemical reaction ATP + L-arginine ⇌ {\ ... L-arginine N-phosphotransferasel ATP:L-arginine, and ω-N-phosphotransferase. This enzyme participates in arginine and proline ... The systematic name of this enzyme class is ATP:L-arginine Nω-phosphotransferase. Other names in common use include arginine ... the two substrates of this enzyme are ATP and L-arginine, whereas its two products are ADP and Nω-phospho-L-arginine. This ...
Serine/Arginine-Rich Protein Kinase Blockade Attenuates Choroidal Neovascularization Zhenyu Dong; Kousuke Noda; Atsuhiro Kanda ... Serine/Arginine-Rich Protein Kinase Blockade Attenuates Choroidal Neovascularization You will receive an email whenever this ... Purpose: To investigate the applicability of serine/arginine-rich protein kinase (SRPK)-specific inhibitor, SRPIN340, for ... Serine/Arginine-Rich Protein Kinase Blockade Attenuates Choroidal Neovascularization. Invest. Ophthalmol. Vis. Sci. 2013;54(15 ...
An siRNA screen revealed that serine-arginine-rich protein kinases linked increased MNK2 activity to decreased eIF4G ... MNK2 Inhibits eIF4G Activation Through a Pathway Involving Serine-Arginine-Rich Protein Kinase in Skeletal Muscle ... MNK2 Inhibits eIF4G Activation Through a Pathway Involving Serine-Arginine-Rich Protein Kinase in Skeletal Muscle ... MNK2 Inhibits eIF4G Activation Through a Pathway Involving Serine-Arginine-Rich Protein Kinase in Skeletal Muscle ...
"Arginine Kinase" by people in this website by year, and whether "Arginine Kinase" was a major or minor topic of these ... "Arginine Kinase" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Arginine Kinase" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Arginine Kinase". ...
To verify our finding that McsB is a protein arginine kinase, we established an in vitro phosphorylation assay (Fig. 3C) using ... A protein kinase can specifically target arginine residues in a transcription factor to regulate its DNA binding. ... A protein kinase can specifically target arginine residues in a transcription factor to regulate its DNA binding. ... Sequence analysis indicated that the McsB protein arginine kinase exhibits no substantial homology to known Ser, Thr, Tyr, or ...
Serine/arginine (SR) protein-specific kinase (SRPK), a family of cell cycle-regulated protein kinases, phosphorylate SR domain- ... Phosphatidylinositol 3-kinase (PI3K) and mitogen-activated protein/extracellular signal-regulated kinase kinase 1 (MEK1) ... Serine/Arginine Protein-Specific Kinase 2 Promotes Leukemia Cell Proliferation by Phosphorylating Acinus and Regulating Cyclin ... SRPK1 and Clk/Sty protein kinases show distinct substrate specificities for serine/arginine-rich splicing factors. J Biol Chem ...
1. Both the monomer arginine kinase from lobster muscle and the dimer arginine kinase from Holothuria forskali catalyse the ATP ... Evolutionary divergence in the mechanism of action of a monomer and a dimer arginine kinase E O Anosike E O Anosike ... Evolutionary divergence in the mechanism of action of a monomer and a dimer arginine kinase. Biochem J 1 June 1976; 155 (3): ... The Mg2+-nucleotide complex is the substrate for this as it is for the kinase reaction. 2. Analogues of arginine inhibit the ...
Serine-Arginine Protein Kinase 1 Overexpression Is Associated with Tumorigenic Imbalance in Mitogen-Activated Protein Kinase ... Serine-Arginine Protein Kinase 1 Overexpression Is Associated with Tumorigenic Imbalance in Mitogen-Activated Protein Kinase ... Serine-Arginine Protein Kinase 1 Overexpression Is Associated with Tumorigenic Imbalance in Mitogen-Activated Protein Kinase ... Serine-Arginine Protein Kinase 1 Overexpression Is Associated with Tumorigenic Imbalance in Mitogen-Activated Protein Kinase ...
Evolutionary divergence in the mechanism of action of a monomer and a dimer arginine kinase. E O Anosike, D C Watts ... Evolutionary divergence in the mechanism of action of a monomer and a dimer arginine kinase ... Evolutionary divergence in the mechanism of action of a monomer and a dimer arginine kinase ... Evolutionary divergence in the mechanism of action of a monomer and a dimer arginine kinase ...
The role of arginines in this acetate kinase was investigated. Five arginines (R91, R175, R241, R285, and R340) in the M. ... this approach has only recently become available for acetate kinase. The enzyme from Methanosarcina thermophila has been cloned ... thermophila enzyme were selected for individual replacement based on their high conservation among sequences of acetate kinase ... with the recombinant wild-type enzyme and variants were consistent with the presence of one or more essential arginine residues ...
... an important member of phosphagen kinase family has been extensively studied in various vertebrates and invertebrates. ... From: Arginine kinase from Haemonchus contortus decreased the proliferation and increased the apoptosis of goat PBMCs in vitro ...
... an important member of phosphagen kinase family has been extensively studied in various vertebrates and invertebrates. ... Arginine kinase (AK), being a highly conserved member of the phosphagen kinase (PKs) family, has been studied extensively with ... Arginine kinase (AK), an important member of phosphagen kinase family has been extensively studied in various vertebrates and ... Many excretory/secretory (ES) products of H. contortus including proteins belong to family phosphagen kinase (arginine kinase) ...
I describe the identification and characterization of Drosophila mutants for a newly-identified serine-arginine protein kinase ... I describe the identification and characterization of Drosophila mutants for a newly-identified serine-arginine protein kinase ...
Carbamate kinase: New structural machinery for making carbamoyl phosphate, the common precursor of pyrimidines and arginine. ... The enzymes carbamoyl phosphate synthetase (CPS) and carbamate kinase (CK) make carbamoyl phosphate in the same way: by ATP- ...
Protein kinase C (PKC) is translocated to a phospholipid bilayer by calcium. Once at the membrane protein kinase C undergoes a ... To study the conformational change in PKC in the absence of a membrane, the interactions between an Arginine-rich peptide (ARP ...
... where the protein arginine kinase McsB (7) is mutated and the amount of cellular arginine phosphorylation is dramatically ... mediated through the interplay between protein arginine kinases and the YwlE protein arginine phosphatase activity, presumably ... 2009) McsB is a protein arginine kinase that phosphorylates and inhibits the heat-shock regulator CtsR. Science 324:1323-1327. ... Our results suggest that in B. subtilis the combined activity of a protein arginine kinase and phosphatase allows a rapid and ...
... xanthus arginine kinase, Ark, and demonstrated that it has retained the ability to catalyze the phosphorylation of arginine by ... Recently, putative arginine kinases were identified in several bacterial species, including the social Gram-negative soil ... Arginine kinases catalyze the reversible transfer of a high-energy phosphoryl group from ATP to L-arginine to form ... Arginine kinases catalyze the reversible transfer of a high-energy phosphoryl group from ATP to L-arginine to form ...
Thus, the cyclic nature, the presence of arginine, ring size, and the number of amino acids in the structure of the peptide ... Among all the peptides, cyclic decapeptide C[RW]5 containing alternative arginine (R) and tryptophan (W) residues was found to ... C[RW]5 was a noncompetitive Src kinase inhibitor, showing approximately fourfold more selectivity towards Src than Abl. ... were found to be critical in Src kinase inhibitory potency. The IC50 value of C[RW]5 was found to be 0.8 μM in a radioactive ...
The purified arginine kinase was used in the immunization of a mouse together with alum (adjuvant), and an anti-shrimp arginine ... Therefore, an anti-shrimp tropomyosin antibody (derived from mouse) and an anti-shrimp arginine kinase antibody (derived from ... Meanwhile, as positive controls for the two antibodies, shrimp tropomyosin (TMS) and shrimp arginine kinase (AK) were ... Conventionally, shrimp tropomyosin (TMS) and shrimp arginine kinase (AK) have been identified as materials causing shrimp ...
Regulation of human neutrophil degranulation by LY-83583 and L-arginine : Role of cGMP-dependent protein kinase. / Wyatt, T. A. ... Regulation of human neutrophil degranulation by LY-83583 and L-arginine: Role of cGMP-dependent protein kinase. American ... title = "Regulation of human neutrophil degranulation by LY-83583 and L-arginine: Role of cGMP-dependent protein kinase", ... Regulation of human neutrophil degranulation by LY-83583 and L-arginine: Role of cGMP-dependent protein kinase. ...
Role of G Protein-coupled Receptor Kinase 5 in Desensitisation of the V1b Vasopressin Receptor in Response to Arginine ... Arginine vasopressin (AVP) is a hypothalamic nonapeptide which regulates the hypothalamic-pituitary-adrenal axis response to ... and may be due to phosphorylation of the receptor by G protein-coupled receptor kinase 5 (GRK5). The aim of this research was ...
  • We have also examined the effect of selective inhibition of this kinase on cancer-relevant processes. (aacrjournals.org)
  • These results suggest that central treatment with SIM decreased sympathetic outflow in CHF rabbits via up-regulation of nNOS expression in RVLM, which may be due to the inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase and a decrease in Rho kinase by SIM. (aspetjournals.org)
  • With the exception of AN-PREG rats, inhibition of NO synthesis with N ω -nitro- l -arginine methyl ester enhanced blood pressure and decreased creatinine clearance but did not influence proteinuria. (ahajournals.org)
  • Identification of the CtsR/McsB arginine phospho-switch expands the repertoire of possible protein modifications involved in prokaryotic and eukaryotic transcriptional regulation. (sciencemag.org)
  • Alterations in the splice pattern and resulting expression of MAPK kinase are implicated in mediating the antitumoral effects resulting from SRPK1 down-regulation. (aacrjournals.org)
  • The up-regulation of SRPK1 in multiple cancers and its ability to regulate multiple relevant signaling pathways provide support for developing agents to inhibit this kinase for possible broad application to treat epithelial cancers. (aacrjournals.org)
  • To date, numerous protein kinase structures have been solved in both active and inactive states, which has provided a general understanding of protein kinase functionality and its regulation ( 1 - 7 ). (pnas.org)
  • Hermoso, Olivero, Torres, Riveros, Quest, Stutzin: Cell volume regulation in response to hypotonicity is impaired in HeLa cells expressing a protein kinase Calpha mutant lacking kinase activity. (antibodies-online.com)
  • The mechanisms through which a cell controls its proliferation, differentiation, metabolism, motility, and ultimate survival in response to extracellular cues are largely controlled by the Ras-extracellular signal-regulated kinase (Ras-ERK) and phosphatidylinositol 3-kinase mammalian target of rapamycin (PI3K-mTOR) signaling pathways. (harvard.edu)
  • We discovered the S6K, AKT and RSK all phosphorylate SRPK2 at serine 494 in a cell-type, stimulus dependent manner, emphasizing the redundant nature of the AGC kinases. (harvard.edu)
  • The cyclin B-p34 cdc2 kinase (CDK1) has been shown to phosphorylate RIIα on T54 and this has been proposed to alter the subcellular localization of RIIα. (biologists.org)
  • Cloning, Expression, and Characterization of an Acetate Kinase from a High Rate of Biohydrogen Bacterial Strain Ethanoligenens sp. (semanticscholar.org)
  • Characterization of the acetate binding pocket in the Methanosarcina thermophila acetate kinase. (semanticscholar.org)
  • Identification and Characterization of a Putative Arginine Kinase Homo" by J. Bragg, Andrei Rajkovic et al. (wooster.edu)
  • 1. Both the monomer arginine kinase from lobster muscle and the dimer arginine kinase from Holothuria forskali catalyse the ATP-ADP partial exchange reaction at rates equal to 3 and 0.6% of the normal rate of transphosphorylation respectively. (portlandpress.com)
  • Evolutionary variation between a monomer and a dimer arginine kinase. (portlandpress.com)
  • Arginine Kinases from the Precious Corals Corallium rubrum and Paracorallium japonicum: Presence of Two Distinct Arginine Kinase Gene Lineages in Cnidarians. (nih.gov)
  • Using transfection studies to insert a defective FAK gene, the authors showed that such cells failed to respond to Arginine indicating that FAK is critical to Arginine's effect. (bmj.com)
  • Particularly high levels of kinase-encoding transcripts, and the use of an alternative polyadenylation site rendering some of the transcripts unstable during early embryogenesis, suggest that a high level of kinase activity is required during the activation of zygotic gene expression. (genetics.org)
  • Protein kinase A activation inhibits DUX4 gene expression in myotubes from patients with facioscapulohumeral muscular dystrophy. (harvard.edu)
  • SRSF6 (Serine And Arginine Rich Splicing Factor 6) is a Protein Coding gene. (genecards.org)
  • June 3, 2013 - The targeted agent crizotinib ( Xalkori ) is superior to standard chemotherapy in patients with previously treated advanced nonsmall-cell lung cancer (NSCLC) and anaplastic lymphoma kinase ( ALK ) gene rearrangement, according to a phase 3 open-label trial published online June 1 in the New England Journal of Medicine . (medscape.com)
  • Mutations in the thymidine kinase gene ( tk ) of herpes simplex virus type 1 (HSV-1) explain most cases of virus resistance to acyclovir (ACV) treatment. (asm.org)
  • Diagnostic characters from the highly variable nuclear protein encoding arginine kinase gene confirmed the presence of two isolated populations. (uni-muenchen.de)
  • Protein kinases are important mediators of signal transduction in eukaryotic cells, and identifying the substrates of these enzymes is essential for a complete understanding of most signaling networks. (genetics.org)
  • PROTEIN kinases are key mediators of signal transduction in all eukaryotic cells. (genetics.org)
  • Identifying kinase substrates is an important step in mapping signal transduction pathways, but remains a difficult and time-consuming process. (pubmedcentralcanada.ca)
  • This study will test the effect of arginine versus citrulline versus placebo supplementation In three groups of ketosis-prone diabetes (KPD) patients on arginine and nitric oxide productio. (bioportfolio.com)
  • Arginine supplementation significantly reduces the incidence of NEC, possibly acting via the mechanisms shown in this paper to enhance intestinal healing. (bmj.com)
  • Recent reports have described multifaceted interactions between the mitogen-activated protein kinase (MAPK) and AKT signaling networks and the splice regulatory machinery. (aacrjournals.org)
  • Thus, the cyclic nature, the presence of arginine, ring size, and the number of amino acids in the structure of the peptide were found to be critical in Src kinase inhibitory potency. (chapman.edu)
  • Taking advantage of the single nonessential SR protein-specific kinase Sky1p in Saccharomyces cerevisiae , we investigated RS domain interactions in vivo using the two-hybrid assay. (rupress.org)
  • Moreover, cell cycle signal induces nuclear translocation of the kinases at the G 2 -M boundary, indicating that SRPKs play a role in cell cycle progression ( 10 ). (aacrjournals.org)
  • Arginine, a widely available dietary amino acid, is a precursor of nitric oxide which itself stimulates epithelial cell migration. (bmj.com)
  • Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans. (semanticscholar.org)
  • Rawashdeh O, Jilg A, Maronde E, Fahrenkrug J, Stehle JH (2017) Period1 gates the circadian modulation of memory-relevant signaling in mouse hippocampus by regulating the nuclear shuttling of the CREB kinase pP90RSK. (uni-frankfurt.de)
  • Arginine vasopressin (AVP) is a hypothalamic nonapeptide which regulates the hypothalamic-pituitary-adrenal axis response to stress by stimulating the secretion of adrenocorticotropin (ACTH) from corticotroph cells of the anterior pituitary. (canterbury.ac.nz)
  • HPr(hisl5-P) also regulates glycerol metabolism through glycerol-3-phosphate kinase. (asmscience.org)
  • Barta, Andrea 2004-10-19 00:00:00 An important group of splicing factors involved in constitutive and alternative splicing contain an arginine/serine (RS)-rich domain. (deepdyve.com)