An enzyme that catalyzes the phosphorylation of the guanidine nitrogen of arginine in the presence of ATP and a divalent cation with formation of phosphorylarginine and ADP. EC 2.7.3.3.
The predominant form of mammalian antidiuretic hormone. It is a nonapeptide containing an ARGININE at residue 8 and two disulfide-linked cysteines at residues of 1 and 6. Arg-vasopressin is used to treat DIABETES INSIPIDUS or to improve vasomotor tone and BLOOD PRESSURE.
An amino acid produced in the urea cycle by the splitting off of urea from arginine.
A ureahydrolase that catalyzes the hydrolysis of arginine or canavanine to yield L-ornithine (ORNITHINE) and urea. Deficiency of this enzyme causes HYPERARGININEMIA. EC 3.5.3.1.
A reagent that is highly selective for the modification of arginyl residues. It is used to selectively inhibit various enzymes and acts as an energy transfer inhibitor in photophosphorylation.
Any member of the class of enzymes that catalyze the cleavage of the substrate and the addition of water to the resulting molecules, e.g., ESTERASES, glycosidases (GLYCOSIDE HYDROLASES), lipases, NUCLEOTIDASES, peptidases (PEPTIDE HYDROLASES), and phosphatases (PHOSPHORIC MONOESTER HYDROLASES). EC 3.
A urea cycle enzyme that catalyzes the formation of orthophosphate and L-citrulline (CITRULLINE) from CARBAMOYL PHOSPHATE and L-ornithine (ORNITHINE). Deficiency of this enzyme may be transmitted as an X-linked trait. EC 2.1.3.3.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
An enzyme of the urea cycle that catalyzes the formation of argininosuccinic acid from citrulline and aspartic acid in the presence of ATP. Absence or deficiency of this enzyme causes the metabolic disease CITRULLINEMIA in humans. EC 6.3.4.5.
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
An essential amino acid. It is often added to animal feed.
Decarboxylated arginine, isolated from several plant and animal sources, e.g., pollen, ergot, herring sperm, octopus muscle.
An enzyme of the urea cycle which splits argininosuccinate to fumarate plus arginine. Its absence leads to the metabolic disease ARGININOSUCCINIC ACIDURIA in man. EC 4.3.2.1.
Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)
A class of enzymes that transfers phosphate groups and has a carboxyl group as an acceptor. EC 2.7.2.
A nonapeptide that contains the ring of OXYTOCIN and the side chain of ARG-VASOPRESSIN with the latter determining the specific recognition of hormone receptors. Vasotocin is the non-mammalian vasopressin-like hormone or antidiuretic hormone regulating water and salt metabolism.
Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Carrier of aroma of butter, vinegar, coffee, and other foods.
The rate dynamics in chemical or physical systems.
Cyclohexane ring substituted by one or more ketones in any position.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
Amino acid transporter systems capable of transporting basic amino acids (AMINO ACIDS, BASIC).
The parts of a macromolecule that directly participate in its specific combination with another molecule.
A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A mitochondrial matrix enzyme that catalyzes the synthesis of L-GLUTAMATE to N-acetyl-L-glutamate in the presence of ACETYL-COA.
A compound formed in the liver from ammonia produced by the deamination of amino acids. It is the principal end product of protein catabolism and constitutes about one half of the total urinary solids.
A high-affinity, low capacity system y+ amino acid transporter found ubiquitously. It has specificity for the transport of ARGININE; LYSINE; and ORNITHINE. It may also act as an ecotropic leukemia retroviral receptor.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
A non-essential amino acid that is synthesized from GLUTAMIC ACID. It is an essential component of COLLAGEN and is important for proper functioning of joints and tendons.
Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
A transfer RNA which is specific for carrying arginine to sites on the ribosomes in preparation for protein synthesis.
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
Enzymes of a subclass of TRANSFERASES that catalyze the transfer of an amidino group from donor to acceptor. EC 2.1.4.
A synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.
Enzymes that catalyze the methylation of amino acids after their incorporation into a polypeptide chain. S-Adenosyl-L-methionine acts as the methylating agent. EC 2.1.1.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
An essential amino acid that is required for the production of HISTAMINE.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
This amino acid is formed during the urea cycle from citrulline, aspartate and ATP. This reaction is catalyzed by argininosuccinic acid synthetase.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Stable nitrogen atoms that have the same atomic number as the element nitrogen, but differ in atomic weight. N-15 is a stable nitrogen isotope.
A colorless alkaline gas. It is formed in the body during decomposition of organic materials during a large number of metabolically important reactions. Note that the aqueous form of ammonia is referred to as AMMONIUM HYDROXIDE.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and glutamine. This enzyme is important in the de novo biosynthesis of pyrimidines. EC 6.3.5.5.
Cellular proteins and protein complexes that transport amino acids across biological membranes.
Proteins prepared by recombinant DNA technology.
Proteins found in any species of bacterium.
The interference in synthesis of an enzyme due to the elevated level of an effector substance, usually a metabolite, whose presence would cause depression of the gene responsible for enzyme synthesis.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Rare autosomal recessive disorder of the urea cycle which leads to the accumulation of argininosuccinic acid in body fluids and severe HYPERAMMONEMIA. Clinical features of the neonatal onset of the disorder include poor feeding, vomiting, lethargy, seizures, tachypnea, coma, and death. Later onset results in milder set of clinical features including vomiting, failure to thrive, irritability, behavioral problems, or psychomotor retardation. Mutations in the ARGININOSUCCINATE LYASE gene cause the disorder.
The monoanhydride of carbamic acid with PHOSPHORIC ACID. It is an important intermediate metabolite and is synthesized enzymatically by CARBAMYL-PHOSPHATE SYNTHASE (AMMONIA) and CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING).
A genus of ascomycetous fungi, family Sordariaceae, order SORDARIALES, comprising bread molds. They are capable of converting tryptophan to nicotinic acid and are used extensively in genetic and enzyme research. (Dorland, 27th ed)
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
A rare autosomal recessive disorder of the urea cycle. It is caused by a deficiency of the hepatic enzyme ARGINASE. Arginine is elevated in the blood and cerebrospinal fluid, and periodic HYPERAMMONEMIA may occur. Disease onset is usually in infancy or early childhood. Clinical manifestations include seizures, microcephaly, progressive mental impairment, hypotonia, ataxia, spastic diplegia, and quadriparesis. (From Hum Genet 1993 Mar;91(1):1-5; Menkes, Textbook of Child Neurology, 5th ed, p51)
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
An element with the atomic symbol N, atomic number 7, and atomic weight [14.00643; 14.00728]. Nitrogen exists as a diatomic gas and makes up about 78% of the earth's atmosphere by volume. It is a constituent of proteins and nucleic acids and found in all living cells.
Established cell cultures that have the potential to propagate indefinitely.
The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.
A subclass of enzymes of the transferase class that catalyze the transfer of an amino group from a donor (generally an amino acid) to an acceptor (generally a 2-keto acid). Most of these enzymes are pyridoxyl phosphate proteins. (Dorland, 28th ed) EC 2.6.1.
A non-essential amino acid. It is found primarily in gelatin and silk fibroin and used therapeutically as a nutrient. It is also a fast inhibitory neurotransmitter.
A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.
An essential branched-chain amino acid important for hemoglobin formation.
An enzyme that activates arginine with its specific transfer RNA. EC 6.1.1.19.
Hormones released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). They include a number of peptides which are formed in the NEURONS in the HYPOTHALAMUS, bound to NEUROPHYSINS, and stored in the nerve terminals in the posterior pituitary. Upon stimulation, these peptides are released into the hypophysial portal vessel blood.
A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
A rather large group of enzymes comprising not only those transferring phosphate but also diphosphate, nucleotidyl residues, and others. These have also been subdivided according to the acceptor group. (From Enzyme Nomenclature, 1992) EC 2.7.
Inorganic or organic salts and esters of nitric acid. These compounds contain the NO3- radical.
The study of crystal structure using X-RAY DIFFRACTION techniques. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
Derivatives of GLUTAMIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the 2-aminopentanedioic acid structure.
Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.
A species of ascomycetous fungi of the family Sordariaceae, order SORDARIALES, much used in biochemical, genetic, and physiologic studies.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
A genus of gram-negative, mostly facultatively anaerobic bacteria in the family MYCOPLASMATACEAE. The cells are bounded by a PLASMA MEMBRANE and lack a true CELL WALL. Its organisms are pathogens found on the MUCOUS MEMBRANES of humans, ANIMALS, and BIRDS.
Amino acids with side chains that are positively charged at physiological pH.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Carrier proteins for OXYTOCIN and VASOPRESSIN. They are polypeptides of about 10-kDa, synthesized in the HYPOTHALAMUS. Neurophysin I is associated with oxytocin and neurophysin II is associated with vasopressin in their respective precursors and during transportation down the axons to the neurohypophysis (PITUITARY GLAND, POSTERIOR).
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Stable carbon atoms that have the same atomic number as the element carbon, but differ in atomic weight. C-13 is a stable carbon isotope.
A toxic diamine formed by putrefaction from the decarboxylation of arginine and ornithine.
Commonly observed structural components of proteins formed by simple combinations of adjacent secondary structures. A commonly observed structure may be composed of a CONSERVED SEQUENCE which can be represented by a CONSENSUS SEQUENCE.
One of the non-essential amino acids commonly occurring in the L-form. It is found in animals and plants, especially in sugar cane and sugar beets. It may be a neurotransmitter.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Proteins that bind to RNA molecules. Included here are RIBONUCLEOPROTEINS and other proteins whose function is to bind specifically to RNA.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM.
A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.
Biogenic amines having more than one amine group. These are long-chain aliphatic compounds that contain multiple amino and/or imino groups. Because of the linear arrangement of positive charge on these molecules, polyamines bind electrostatically to ribosomes, DNA, and RNA.
A serine endopeptidase that is formed from TRYPSINOGEN in the pancreas. It is converted into its active form by ENTEROPEPTIDASE in the small intestine. It catalyzes hydrolysis of the carboxyl group of either arginine or lysine. EC 3.4.21.4.
Nutritional support given via the alimentary canal or any route connected to the gastrointestinal system (i.e., the enteral route). This includes oral feeding, sip feeding, and tube feeding using nasogastric, gastrostomy, and jejunostomy tubes.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A mutation in which a codon is mutated to one directing the incorporation of a different amino acid. This substitution may result in an inactive or unstable product. (From A Dictionary of Genetics, King & Stansfield, 5th ed)
A nonapeptide hormone released from the neurohypophysis (PITUITARY GLAND, POSTERIOR). It differs from VASOPRESSIN by two amino acids at residues 3 and 8. Oxytocin acts on SMOOTH MUSCLE CELLS, such as causing UTERINE CONTRACTIONS and MILK EJECTION.
The sum of the weight of all the atoms in a molecule.
A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.
The process of cleaving a chemical compound by the addition of a molecule of water.
The region of an enzyme that interacts with its substrate to cause the enzymatic reaction.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Substances which reduce or eliminate dentinal sensitivity or the pain associated with a source of stimulus (such as touch, heat, or cold) at the orifice of exposed dentinal tubules causing the movement of tubular fluid that in turn stimulates tooth nerve receptors.
A family of iminourea derivatives. The parent compound has been isolated from mushrooms, corn germ, rice hulls, mussels, earthworms, and turnip juice. Derivatives may have antiviral and antifungal properties.
The functional hereditary units of BACTERIA.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A competitive inhibitor of nitric oxide synthetase.
Family of large marine CRUSTACEA, in the order DECAPODA. These are called clawed lobsters because they bear pincers on the first three pairs of legs. The American lobster and Cape lobster in the genus Homarus are commonly used for food.
Enzymes that catalyze the joining of glutamine-derived ammonia and another molecule. The linkage is in the form of a carbon-nitrogen bond. EC 6.3.5.
A class of enzymes that catalyze oxidation-reduction reactions of amino acids.
Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.
Proteins obtained from ESCHERICHIA COLI.
The amounts of various substances in food needed by an organism to sustain healthy life.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
An organic compound used often as a reagent in organic synthesis, as a flavoring agent, and in tanning. It has been demonstrated as an intermediate in the metabolism of acetone and its derivatives in isolated cell preparations, in various culture media, and in vivo in certain animals.
A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
An enzyme that catalyzes the formation of carbamoyl phosphate from ATP, carbon dioxide, and ammonia. This enzyme is specific for arginine biosynthesis or the urea cycle. Absence or lack of this enzyme may cause CARBAMOYL-PHOSPHATE SYNTHASE I DEFICIENCY DISEASE. EC 6.3.4.16.
The concentration of osmotically active particles in solution expressed in terms of osmoles of solute per liter of solution. Osmolality is expressed in terms of osmoles of solute per kilogram of solvent.
Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.
A pyridoxal-phosphate protein, believed to be the rate-limiting compound in the biosynthesis of polyamines. It catalyzes the decarboxylation of ornithine to form putrescine, which is then linked to a propylamine moiety of decarboxylated S-adenosylmethionine to form spermidine.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Membrane proteins whose primary function is to facilitate the transport of molecules across a biological membrane. Included in this broad category are proteins involved in active transport (BIOLOGICAL TRANSPORT, ACTIVE), facilitated transport and ION CHANNELS.
Salts of nitrous acid or compounds containing the group NO2-. The inorganic nitrites of the type MNO2 (where M=metal) are all insoluble, except the alkali nitrites. The organic nitrites may be isomeric, but not identical with the corresponding nitro compounds. (Grant & Hackh's Chemical Dictionary, 5th ed)
A disease that is characterized by frequent urination, excretion of large amounts of dilute URINE, and excessive THIRST. Etiologies of diabetes insipidus include deficiency of antidiuretic hormone (also known as ADH or VASOPRESSIN) secreted by the NEUROHYPOPHYSIS, impaired KIDNEY response to ADH, and impaired hypothalamic regulation of thirst.
Transport proteins that carry specific substances in the blood or across cell membranes.
Elements of limited time intervals, contributing to particular results or situations.
A strong organic base existing primarily as guanidium ions at physiological pH. It is found in the urine as a normal product of protein metabolism. It is also used in laboratory research as a protein denaturant. (From Martindale, the Extra Pharmacopoeia, 30th ed and Merck Index, 12th ed) It is also used in the treatment of myasthenia and as a fluorescent probe in HPLC.
Neural tissue of the pituitary gland, also known as the neurohypophysis. It consists of the distal AXONS of neurons that produce VASOPRESSIN and OXYTOCIN in the SUPRAOPTIC NUCLEUS and the PARAVENTRICULAR NUCLEUS. These axons travel down through the MEDIAN EMINENCE, the hypothalamic infundibulum of the PITUITARY STALK, to the posterior lobe of the pituitary gland.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Amino acids that are not synthesized by the human body in amounts sufficient to carry out physiological functions. They are obtained from dietary foodstuffs.
An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
The accumulation of an electric charge on a object
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.
An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Biochemical identification of mutational changes in a nucleotide sequence.
Disorders affecting amino acid metabolism. The majority of these disorders are inherited and present in the neonatal period with metabolic disturbances (e.g., ACIDOSIS) and neurologic manifestations. They are present at birth, although they may not become symptomatic until later in life.
The withholding of water in a structured experimental situation.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A peptide of about 41 amino acids that stimulates the release of ADRENOCORTICOTROPIC HORMONE. CRH is synthesized by neurons in the PARAVENTRICULAR NUCLEUS of the HYPOTHALAMUS. After being released into the pituitary portal circulation, CRH stimulates the release of ACTH from the PITUITARY GLAND. CRH can also be synthesized in other tissues, such as PLACENTA; ADRENAL MEDULLA; and TESTIS.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
The process of moving proteins from one cellular compartment (including extracellular) to another by various sorting and transport mechanisms such as gated transport, protein translocation, and vesicular transport.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Regular course of eating and drinking adopted by a person or animal.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
A mutant strain of Rattus norvegicus used in research on renal function and hypertension and as a disease model for diabetes insipidus.
A CALCIUM-independent subtype of nitric oxide synthase that may play a role in immune function. It is an inducible enzyme whose expression is transcriptionally regulated by a variety of CYTOKINES.
The balance of fluid in the BODY FLUID COMPARTMENTS; total BODY WATER; BLOOD VOLUME; EXTRACELLULAR SPACE; INTRACELLULAR SPACE, maintained by processes in the body that regulate the intake and excretion of WATER and ELECTROLYTES, particularly SODIUM and POTASSIUM.
Deficiency of sodium in the blood; salt depletion. (Dorland, 27th ed)
A non-essential amino acid occurring in natural form as the L-isomer. It is synthesized from GLYCINE or THREONINE. It is involved in the biosynthesis of PURINES; PYRIMIDINES; and other amino acids.
Enzymes that transfer the ADP-RIBOSE group of NAD or NADP to proteins or other small molecules. Transfer of ADP-ribose to water (i.e., hydrolysis) is catalyzed by the NADASES. The mono(ADP-ribose)transferases transfer a single ADP-ribose. POLY(ADP-RIBOSE) POLYMERASES transfer multiple units of ADP-ribose to protein targets, building POLY ADENOSINE DIPHOSPHATE RIBOSE in linear or branched chains.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
Enzymes catalyzing the transfer of an acetyl group, usually from acetyl coenzyme A, to another compound. EC 2.3.1.
A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.

Arginine methylation and binding of Hrp1p to the efficiency element for mRNA 3'-end formation. (1/10469)

Hrp1p is a heterogeneous ribonucleoprotein (hnRNP) from the yeast Saccharomyces cerevisiae that is involved in the cleavage and polyadenylation of the 3'-end of mRNAs and mRNA export. In addition, Hrplp is one of several RNA-binding proteins that are posttranslationally modified by methylation at arginine residues. By using functional recombinant Hrp1p, we have identified RNA sequences with specific high affinity binding sites. These sites correspond to the efficiency element for mRNA 3'-end formation, UAUAUA. To examine the effect of methylation on specific RNA binding, purified recombinant arginine methyltransferase (Hmt1p) was used to methylate Hrp1p. Methylated Hrp1p binds with the same affinity to UAUAUA-containing RNAs as unmethylated Hrpl p indicating that methylation does not affect specific RNA binding. However, RNA itself inhibits the methylation of Hrp1p and this inhibition is enhanced by RNAs that specifically bind Hrpl p. Taken together, these data support a model in which protein methylation occurs prior to protein-RNA binding in the nucleus.  (+info)

Gamma interferon stimulates rat alveolar macrophages to kill Pneumocystis carinii by L-arginine- and tumor necrosis factor-dependent mechanisms. (2/10469)

Pneumocystis carinii pneumonia remains a serious complication for immunocompromised patients. In the present study, P. carinii organisms interacted with gamma interferon (IFN-gamma)-stimulated alveolar macrophages (AMs) to activate the L-arginine-dependent cytocidal pathway involving reactive nitrogen intermediates (RNI) that were assayed as nitrite (NO2-). Unstimulated cultures of AMs produced negligible quantities of RNI. Addition of P. carinii organisms to IFN-gamma-primed AMs resulted in greatly enhanced production of RNI. NO2- levels increased from 0.8 +/- 0.4 to 11.1 +/- 3.8 microM as early as 6 h after P. carinii organisms were incubated with IFN-gamma-stimulated AMs and to 35.1 +/- 8.9 microM after a 24-h incubation, a near-maximum level. High levels of NO2- were produced by AMs primed with as little as 10 U of IFN-gamma per ml in the presence of P. carinii, and a 20-fold increase in IFN-gamma concentration resulted in only a further 65% increase in NO2- production. RNI-dependent killing of P. carinii was demonstrated by both a 51Cr release assay and a [35S]methionine pulse immunoprecipitation assay. Addition of either monoclonal tumor necrosis factor alpha (TNF-alpha) neutralizing antibody or 200 microM NG-monomethyl-L-arginine (L-NGMMA), a competitive inhibitor of the L-arginine-dependent pathway, significantly decreased NO2- production and reduced P. carinii killing. TNF-alpha alone had no effect on P. carinii viability. These results suggest that (i) the specific interaction of P. carinii organisms with IFN-gamma-primed AMs triggers the production of RNI, (ii) RNI are toxic to P. carinii, and (iii) TNF-alpha likely plays a central role in mediating P. carinii killing by IFN-gamma-stimulated AMs.  (+info)

Inhibition of transforming growth factor beta production by nitric oxide-treated chondrocytes: implications for matrix synthesis. (3/10469)

OBJECTIVE: Nitric oxide (NO) is generated copiously by articular chondrocytes activated by interleukin-1beta (IL-1beta). If NO production is blocked, much of the IL-1beta inhibition of proteoglycan synthesis is prevented. We tested the hypothesis that this inhibitory effect of NO on proteoglycan synthesis is secondary to changes in chondrocyte transforming growth factor beta (TGFbeta). METHODS: Monolayer, primary cultures of lapine articular chondrocytes and cartilage slices were studied. NO production was determined as nitrite accumulation in the medium. TGFbeta bioactivity in chondrocyte- and cartilage-conditioned medium (CM) was measured with the mink lung epithelial cell bioassay. Proteoglycan synthesis was measured as the incorporation of 35S-sodium sulfate into macromolecules separated from unincorporated label by gel filtration on PD-10 columns. RESULTS: IL-1beta increased active TGFbeta in chondrocyte CM by 12 hours; by 24 hours, significant increases in both active and latent TGFbeta were detectable. NG-monomethyl-L-arginine (L-NMA) potentiated the increase in total TGFbeta without affecting the early TGFbeta activation. IL-1beta stimulated a NO-independent, transient increase in TGFbeta3 at 24 hours; however, TGFbeta1 was not changed. When NO synthesis was inhibited with L-NMA, IL-1beta increased CM concentrations of TGFbeta1 from 24-72 hours of culture. L-arginine (10 mM) reversed the inhibitory effect of L-NMA on NO production and blocked the increases in TGFbeta1. Anti-TGFbeta1 antibody prevented the restoration of proteoglycan synthesis by chondrocytes exposed to IL-1beta + L-NMA, confirming that NO inhibition of TGFbeta1 in IL-1beta-treated chondrocytes effected, in part, the decreased proteoglycan synthesis. Furthermore, the increase in TGFbeta and proteoglycan synthesis seen with L-NMA was reversed by the NO donor S-nitroso-N-acetylpenicillamide. Similar results were seen with cartilage slices in organ culture. The autocrine increase in CM TGFbeta1 levels following prior exposure to TGFbeta1 was also blocked by NO. CONCLUSION: NO can modulate proteoglycan synthesis indirectly by decreasing the production of TGFbeta1 by chondrocytes exposed to IL-1beta. It prevents autocrine-stimulated increases in TGFbeta1, thus potentially diminishing the anabolic effects of this cytokine in chondrocytes.  (+info)

Phe161 and Arg166 variants of p-hydroxybenzoate hydroxylase. Implications for NADPH recognition and structural stability. (4/10469)

Phe161 and Arg166 of p-hydroxybenzoate hydroxylase from Pseudomonas fluorescens belong to a newly discovered sequence motif in flavoprotein hydroxylases with a putative dual function in FAD and NADPH binding [1]. To study their role in more detail, Phe161 and Arg166 were selectively changed by site-directed mutagenesis. F161A and F161G are catalytically competent enzymes having a rather poor affinity for NADPH. The catalytic properties of R166K are similar to those of the native enzyme. R166S and R166E show impaired NADPH binding and R166E has lost the ability to bind FAD. The crystal structure of substrate complexed F161A at 2.2 A is indistinguishable from the native enzyme, except for small changes at the site of mutation. The crystal structure of substrate complexed R166S at 2.0 A revealed that Arg166 is important for providing an intimate contact between the FAD binding domain and a long excursion of the substrate binding domain. It is proposed that this interaction is essential for structural stability and for the recognition of the pyrophosphate moiety of NADPH.  (+info)

Possible role for ligand binding of histidine 81 in the second transmembrane domain of the rat prostaglandin F2alpha receptor. (5/10469)

For the five principal prostanoids PGD2, PGE2, PGF2alpha, prostacyclin and thromboxane A2 eight receptors have been identified that belong to the family of G-protein-coupled receptors. They display an overall homology of merely 30%. However, single amino acids in the transmembrane domains such as an Arg in the seventh transmembrane domain are highly conserved. This Arg has been identified as part of the ligand binding pocket. It interacts with the carboxyl group of the prostanoid. The aim of the current study was to analyze the potential role in ligand binding of His-81 in the second transmembrane domain of the rat PGF2alpha receptor, which is conserved among all PGF2alpha receptors from different species. Molecular modeling suggested that this residue is located in close proximity to the ligand binding pocket Arg 291 in the 7th transmembrane domain. The His81 (H) was exchanged by site-directed mutagenesis to Gln (Q), Asp (D), Arg (R), Ala (A) and Gly (G). The receptor molecules were N-terminally extended by a Flag epitope for immunological detection. All mutant proteins were expressed at levels between 50% and 80% of the wild type construct. The H81Q and H81D receptor bound PGF2alpha with 2-fold and 25-fold lower affinity, respectively, than the wild type receptor. Membranes of cells expressing the H81R, H81A or H81G mutants did not bind significant amounts of PGF2alpha. Wild type receptor and H81Q showed a shallow pH optimum for PGF2alpha binding around pH 5.5 with almost no reduction of binding at higher pH. In contrast the H81D mutant bound PGF2alpha with a sharp optimum at pH 4.5, a pH at which the Asp side chain is partially undissociated and may serve as a hydrogen bond donor as do His and Gln at higher pH values. The data indicate that the His-81 in the second transmembrane domain of the PGF2alpha receptor in concert with Arg-291 in the seventh transmembrane domain may be involved in ligand binding, most likely not by ionic interaction with the prostaglandin's carboxyl group but rather as a hydrogen bond donor.  (+info)

R73A and H144Q mutants of the yeast mitochondrial cyclophilin Cpr3 exhibit a low prolyl isomerase activity in both peptide and protein-folding assays. (6/10469)

Previously we reported that the R73A and H144Q variants of the yeast cyclophilin Cpr3 were virtually inactive in a protease-coupled peptide assay, but retained activity as catalysts of a proline-limited protein folding reaction [Scholz, C. et al. (1997) FEBS Lett. 414, 69-73]. A reinvestigation revealed that in fact these two mutations strongly decrease the prolyl isomerase activity of Cpr3 in both the peptide and the protein-folding assay. The high folding activities found previously originated from a contamination of the recombinant Cpr3 proteins with the Escherichia coli protein SlyD, a prolyl isomerase that co-purifies with His-tagged proteins. SlyD is inactive in the peptide assay, but highly active in the protein-folding assay.  (+info)

The stimulatory effects of Hofmeister ions on the activities of neuronal nitric-oxide synthase. Apparent substrate inhibition by l-arginine is overcome in the presence of protein-destabilizing agents. (7/10469)

A variety of monovalent anions and cations were effective in stimulating both calcium ion/calmodulin (Ca2+/CaM)-independent NADPH-cytochrome c reductase activity of, and Ca2+/CaM-dependent nitric oxide (NO.) synthesis by, neuronal nitric oxide synthase (nNOS). The efficacy of the ions in stimulating both activities could be correlated, in general, with their efficacy in precipitating or stabilizing certain proteins, an order referred to as the Hofmeister ion series. In the hemoglobin capture assay, used for measurement of NO. production, apparent substrate inhibition by L-arginine was almost completely reversed by the addition of sodium perchlorate (NaClO4), one of the more effective protein-destabilizing agents tested. Examination of this phenomenon by the assay of L-arginine conversion to L-citrulline revealed that the stimulatory effect of NaClO4 on the reaction was observed only in the presence of oxyhemoglobin or superoxide anion (generated by xanthine and xanthine oxidase), both scavengers of NO. Spectrophotometric examination of nNOS revealed that the addition of NaClO4 and a superoxide-generating system, but neither alone, prevented the increase of heme absorption at 436 nm, which has been attributed to the nitrosyl complex. The data are consistent with the release of autoinhibitory NO. coordinated to the prosthetic group of nNOS, which, in conjunction with an NO. scavenger, causes stimulation of the reaction.  (+info)

Cystic fibrosis-associated mutations at arginine 347 alter the pore architecture of CFTR. Evidence for disruption of a salt bridge. (8/10469)

Arginine 347 in the sixth transmembrane domain of cystic fibrosis transmembrane conductance regulator (CFTR) is a site of four cystic fibrosis-associated mutations. To better understand the function of Arg-347 and to learn how mutations at this site disrupt channel activity, we mutated Arg-347 to Asp, Cys, Glu, His, Leu, or Lys and examined single-channel function. Every Arg-347 mutation examined, except R347K, had a destabilizing effect on the pore, causing the channel to flutter between two conductance states. Chloride flow through the larger conductance state was similar to that of wild-type CFTR, suggesting that the residue at position 347 does not interact directly with permeating anions. We hypothesized that Arg-347 stabilizes the channel through an electrostatic interaction with an anionic residue in another transmembrane domain. To test this, we mutated anionic residues (Asp-924, Asp-993, and Glu-1104) to Arg in the context of either R347E or R347D mutations. Interestingly, the D924R mutation complemented R347D, yielding a channel that behaved like wild-type CFTR. These data suggest that Arg-347 plays an important structural role in CFTR, at least in part by forming a salt bridge with Asp-924; cystic fibrosis-associated mutations disrupt this interaction.  (+info)

TY - JOUR. T1 - Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans. T2 - The sympathetic activity and ambulatory blood pressure in Africans study. AU - Reimann, Manja. AU - Hamer, Mark. AU - Malan, Nicolaas T.. AU - Schlaich, Markus P.. AU - Lambert, Gavin W.. AU - Ziemssen, Tjalf. AU - Boeger, Rainer H.. AU - Malan, Leoné. PY - 2013. Y1 - 2013. N2 - Objective: This study investigated the impact of stress on effectors of the L-arginine/nitric oxide (NO) system including the endogenous inhibitor asymmetric dimethylarginine (ADMA). Methods: Black (n = 168) and white (n = 206) South African teachers were exposed to a mental and a physical stressor for 1 minute, respectively. Serum samples for determination of L-arginine, NO metabolites, ADMA, and symmetric dimethylarginine (SDMA) were obtained at rest and during stress exposure. Perception of task stressfulness was assessed on a 7-point Likert scale, and psychological distress was estimated ...
TY - JOUR. T1 - Endogenous nitric oxide synthase inhibitors, arterial hemodynamics, and subclinical vascular disease. T2 - The PREVENCION study. AU - Chirinos, Julio A.. AU - David, Robert. AU - Bralley, J. Alexander. AU - Zea-Díaz, Humberto. AU - Muñoz-Atahualpa, Edgar. AU - Corrales-Medina, Fernando. AU - Cuba-Bustinza, Carolina. AU - Chirinos-Pacheco, Julio. AU - Medina-Lezama, Josefina. PY - 2008/12. Y1 - 2008/12. N2 - Endogenous NO synthase inhibitors (end-NOSIs) have been associated with cardiovascular risk factors and atherosclerosis. In addition, end-NOSIs may directly cause hypertension through hemodynamic effects. We aimed to examine the association between end-NOSI asymmetrical dimethylarginine (ADMA) and N-guanidino-monomethyl-arginine (NMMA), subclinical atherosclerosis, and arterial hemodynamics. We studied 922 adults participating in a population-based study (PREVENCION Study) and examined the correlation between end-NOSI/L-arginine and arterial hemodynamics, carotid-femoral ...
Background Fetal Growth Restriction is often associated with a feto-placental vascular dysfunction conceivably involving endothelial cells. Our study aimed to verify this pathogenic role for feto-placental endothelial cells and, coincidentally, demonstrate any abnormality in the nitric oxide system. Methods Prenatal assessment of feto-placental vascular function was combined with measurement of nitric oxide (in the form of S-nitrosohemoglobin) and its nitrite byproduct, and of the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine. Umbilical vein endothelial cells were also harvested to determine their gene profile. The study comprised term pregnancies with normal (n = 40) or small-for-gestational-age (n = 20) newborns, small-for-gestational-age preterm pregnancies (n = 15), and bi-chorial, bi-amniotic twin pregnancies with discordant fetal growth (n = 12). Results Umbilical blood nitrite (p|0.001) and S-nitrosohemoglobin (p = 0.02) rose with fetal growth restriction while
BACKGROUND Nitric oxide (NO) plays an important part in lowering pulmonary vascular resistance after birth, and in persistent pulmonary hypertension of the newborn (PPHN), NO-mediated dilation is dysfunctional. The endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA) circulates in plasma, and its concentrations are elevated in certain cardiovascular diseases, including pulmonary hypertension. ADMA is metabolized by the enzyme dimethylarginine dimethylaminohydrolase (DDAH), the activity of which regulates ADMA concentrations and provides a mechanism for modulating NO synthase in vivo. We investigated the changes in expression and activity of the 2 isoforms of DDAH in lungs from newborn piglets both during normal development and in PPHN. METHODS AND RESULTS Using Western blotting, we showed that DDAHI expression did not change in the normal developing lung; however, DDAHII increased after birth and reached a peak at 1 day. This was reflected in an increase in total DDAH activity according
Arginine supplementation has been shown to alleviate endothelial dysfunction and improve exercise performance through increasing nitric oxide production in patients with cardiopulmonary diseases. In addition, arginine supplementation could decrease accumulations of lactate and ammonia, metabolites involved in development of muscular fatigue. The aim of this study was to investigate the effect of short-term arginine supplementation on performance in intermittent anaerobic exercise and the underlying mechanism in well-trained male athletes. Ten elite male college judo athletes participated with a randomized crossover, placebo-controlled design. The subjects consumed 6 g/day arginine (ARG trial) or placebo (CON trial) for 3 days then performed an intermittent anaerobic exercise test on a cycle ergometer. Blood samples were collected before supplementation, before and during exercise and 0, 3, 6, 10, 30 and 60 min after exercise. ARG trial had significantly higher arginine concentrations than CON ...
Arginine (ARG) and nitric oxide maintain the mucosal integrity of the intestine in various intestinal disorders. In the present study, we evaluated the effects of oral ARG supplementation on intestinal structural changes, enterocyte proliferation and apoptosis following methotrexate (MTX)-induced intestinal damage in a rat. Male rats were divided into four experimental groups: Control rats, CONTR-ARG rats, were treated with oral ARG given in drinking water 72 hours before and 72 hours following vehicle injection, MTX rats were treated with a single dose of methotrexate, and MTX-ARG rats were treated with oral ARG following injection of MTX. Intestinal mucosal damage, mucosal structural changes, enterocyte proliferation and enterocyte apoptosis were determined 72 hours following MTX injection. RT-PCR was used to determine bax and bcl-2 mRNA expression. MTX-ARG rats demonstrated greater jejunal and ileal bowel weight, greater ileal mucosal weight, greater ileal mucosal DNA and protein levels, greater
In this study, SNP rs1241321 in DDAH1 was found to be associated with a higher risk of type 2 diabetes independently of the plasma ADMA level. In addition, individuals with an AA genotype at rs1241321 appeared to be more insulin-sensitive when compared with AG/GG individuals. Over a median follow-up period of 28.2 months, AA genotype at rs1241321 was associated with better long-term clinical outcome in diabetic subgroup. In contrast, some SNPs of DDAH1, especially the rs1498373, might influence the plasma level of ADMA. However, with the exception of rs1241321, none of these SNPs or the plasma ADMA level was associated with type 2 diabetes, suggesting that the interaction of DDAH1 variants with type 2 diabetes may not be directly related to its enzymatic activity, i.e. not just simply mediated by the plasma ADMA level. We also identified a common haplotype H5 (GGCAGC) that was associated with reduced risk of type 2 diabetes.. It is well recognized that type 2 diabetes and its metabolic ...
TY - JOUR. T1 - Role of l-arginine in nitric oxide production in health and hypertension. AU - Rajapakse, Niwanthi W.. AU - Mattson, David L.. PY - 2009/3. Y1 - 2009/3. N2 - l-Arginine is the substrate for vascular nitric oxide (NO) formation. Under normal physiological conditions, intracellular l-arginine levels far exceed the Km of NO synthase for l-arginine. However, endogenous NO formation is dependent on extracellular l-arginine concentrations, giving rise to the concept of the l-arginine paradox. Nitric oxide production in epithelial and endothelial cells is closely coupled to cellular l-arginine uptake, indicating that l-arginine transport mechanisms play a major role in the regulation of NO-dependent function. Consistent with the data in endothelial and epithelial cells are functional data indicating that exogenous l-arginine can increase renal vascular and tubular NO bioavailability and thereby influence kidney perfusion, function and arterial pressure. The integrated effect of ...
Elevated levels of asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA) are accompanied by endothelial dysfunction and predict adverse outcome after ischemic stroke. Via induction of oxidative stress, dimethylarginines are possibly linked to the inflammatory cascade after stroke that is known to considerably contribute to secondary progression of brain injury. We sought to investigate the association between dimethylarginines and inflammatory mediators in patients with acute ischemic stroke. Plasma levels of ADMA and SDMA were measured in prospectively collected blood samples of 58 patients with acute ischemic stroke. Blood samples were taken at 6 hours, 12 hours, 24 hours, 3 days and 7 days after onset of symptoms. Analyses of ADMA and SDMA were done by high-performance liquid chromatography-tandem mass spectrometry. Monocyte chemotactic protein-1 (MCP-1), matrix metalloproteinase-9 (MMP-9), tissue inhibitor of matrix metalloproteinase-1 (TIMP-1), interleukin-6 (IL-6), C-reactive
We describe in depth the structure of complexes formed between DNA and two classes of arginine-containing peptide amphiphiles, namely, the lipopeptide PRW-C16 (P = proline, R = arginine, W = tryptophan, C16 = C16 : 0 alkyl chain) and the bolaamphiphile RFL4FR (R = arginine, F = phenylalanine, L = leucine). A Biological soft matter
Figure 1: Serum Symmetric Dimethylarginine as an Early Marker of Excretory Dysfunction in Canine Leishmaniosis|i| (L. infantum)|/i| Induced Nephropathy
Background: Asymmetric dimethylarginine (ADMA) and NG-monomethyl-L-arginine (NMMA), endogenous nitric oxide-synthase inhibitors (End-NOSI), have been associated with cardiovascular risk factors (CVRF) and atherosclerosis. In addition, acute administration of NOSI cause hypertension through hemodynamic effects, but whether circulating End-NOSI are associated with these abnormalities is unknown.. Methods: We studied 922 adults in a population-based study (PREVENCION study). We examined the correlation between End-NOSI/L-arginine and CVRF, as well as the relationship between these biomarkers and arterial hemodynamics, carotid-femoral pulse wave velocity (cf-PWV) and carotid intima-media thickness (c-IMT). We used general linear modeling for statistical analyses. Estimates (β) are standardized.. Results: In multivariate analyses, LDL-cholesterol and C-reactive protein (CRP) were independent predictors of ADMA, whereas LDL-cholesterol and gender independently predicted NMMA. Age, gender, ...
Nitric oxide (NO) is a potent endogenous vasodilator and has shown to inhibit key processes of atherosclerosis like monocyte adhesion, platelet aggregation, and vascular smooth muscle cell proliferation. Impaired endothelial NO production is a main feature of endothelial dysfunction, which by itself is an early step in the course of atherosclerotic vascular disease.. Recent studies could confirm this close association between parameters of the NO pathway and cardiovascular disease and could further enhance the knowledge on the pathophysiological mechanisms. There is a significant relationship between insulin resistance and the endogenous NO synthase inhibitor asymmetric dimethylarginine (ADMA). Moreover, evidence could be provided that plasma levels of ADMA are a strong and independent predictor of mortality and cardiovascular outcome in haemodialysis patients.. Patients with growth hormone deficiency are characterized by a 1.9 fold higher risk of death from cardiovascular disease. Again, there ...
The main finding in this study is that in essential hypertensives the endogenous inhibitor of e-NOS ADMA is inversely related to endothelial function as measured by the peak hemodynamic response to ACh. Such relationship occurs in a range of ADMA values within the boundaries of the normal range. A companion, unexpected, finding in this study is that circulating L-arginine is directly related to plasma ADMA and, like plasma ADMA, it is inversely related to endothelial function.. The importance of ADMA as an endogenous inhibitor of e-NOS is now well established (26-28). Elegant studies in healthy volunteers convincingly demonstrated that intravenous ADMA infusion at a dose resulting in pathophysiological concentrations augments peripheral and renovascular resistance and arterial pressure (22). High plasma ADMA concentration was observed in the presence of traditional or emerging cardiovascular risk factors (e.g., hyperhomocysteinemia) (18-21,29), inducing endothelial dysfunction in some of these ...
AB - BackgroundDimethylarginine dimethylaminohydrolase 2 (DDAH2) regulates the synthesis of nitric oxide (NO) through the metabolism of the endogenous inhibitor of nitric oxide synthase, asymmetric dimethylarginine (ADMA). Pilot studies have associated the rs805305 SNP of DDAH2 with ADMA concentrations in sepsis. This study explored the impact of the rs805305 polymorphism on DDAH activity and outcome in septic shock.MethodsWe undertook a secondary analysis of data and samples collected during the Vasopressin versus noradrenaline as initial therapy in septic shock (VANISH) trial. Plasma and DNA samples isolated from 286 patients recruited into the VANISH trial were analysed. Concentrations of L-Arginine and the methylarginines ADMA and symmetric dimethylarginine (SDMA) were determined from plasma samples. Whole blood and buffy-coat samples were genotyped for polymorphisms of DDAH2. Clinical data collected during the study were used to explore the relationship between circulating methylarginines, ...
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The abnormal regulation of inducible nitric oxide synthase (iNOS) and neuronal nitric oxide synthase (nNOS) is associated with neurodegenerative disorders. Recombinant arginine deiminase (rADI) is a selective NO modulator of iNOS and eNOS in endothelial cells, and it also exhibits neuroprotective activity in an iNOS-induced neuron-microglia coculture system. However, the effect of rADI on nNOS remains unknown. Addressing this issue is important for evaluating the potential application of rADI in neurodegenerative diseases. SH-SY5Y cells were treated with |i|N|/i|-methyl-D-aspartic acid (NMDA) to activate nNOS. NMDA increased NO production by 39.7 ± 3.9% via nNOS under arginine-containing conditions, but there was no significant increase in both arginine-free and rADI pretreated arginine-containing (citrulline) buffer. Subsequently, neither NMDA nor rADI alone caused cytotoxicity, whereas cotreatment with NMDA and rADI resulted in dissipation of the cell mitochondrial membrane potential and
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SR GROUP - Exporter, Importer, Manufacturer, Distributor, Supplier, Trading Company of ADMA(Asymmetrical Dimethylarginine) ELISA Kit based in Delhi, India
TY - JOUR. T1 - Hyperglycemia, asymmetric dimethylarginine, and patient survival. T2 - Dysregulation of complex networks and the metabolic basis of disease. AU - Castillo, Leticia. AU - Al-Khadra, Eman. PY - 2005/3/1. Y1 - 2005/3/1. KW - Amino acid pool. KW - Asymmetric dimethylarginine. KW - Nutrients. KW - Peroxisome proliferator-activated receptor-γ. UR - http://www.scopus.com/inward/record.url?scp=14944354288&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=14944354288&partnerID=8YFLogxK. U2 - 10.1097/01.CCM.0000155775.30228.33. DO - 10.1097/01.CCM.0000155775.30228.33. M3 - Editorial. C2 - 15753766. AN - SCOPUS:14944354288. VL - 33. SP - 674. EP - 676. JO - Critical Care Medicine. JF - Critical Care Medicine. SN - 0090-3493. IS - 3. ER - ...
L-arginine Plus® stands out as the premier l-arginine formula because it is so much more than what you get with most l-arginine products. This formula is recommended more than any other product on the market because it works faster and works more effectively. Dont settle for simple l-arginine when you can get L-arginine Plus®. Heres what comes with every serving of L-arginine Plus®:. 5,110mg L-arginine - L-arginine is the driving force behind L-arginine Plus®. WIth the best l-arginine available, L-arginine Plus® works quickly to help promote nitric oxide production. Take notice because you get more l-arginine in L-arginine Plus® than in any other supplement. 1,010mg L-citrulline - L-citrulline paired with l-arginine ensures long-lasting nitric oxide production for better support for your heart. L-citrulline works over time to enable nitric oxide production that lasts and lasts so you see better results. Astragin™ - Astragin™ is a patented ingredient that sets L-arginine Plus® apart ...
L-Arginine supplementation in pregnant women with mild chronic hypertension does not significantly affect overall blood pressure but is associated with less need for antihypertensive medications and a trend toward fewer maternal and neonatal complicatio
BACKGROUND: Asymmetric dimethylarginine (ADMA) has been suggested as a possible marker of endothelial dysfunction, and interest in its use in clinical practice is increasing. However, the potential role of symmetric dimethylarginine (SDMA) as an endogenous marker of renal function, has been less widely investigated. The aims of the present study were therefore to determine reference values for dimethylarginines in plasma after method validation, and to ascertain ADMA plasma concentrations in patients with disorders characterized by endothelial dysfunction; a further end-point was to investigate the relationship between SDMA plasma concentrations and estimated GFR (eGFR) as well as plasmatic creatinine in patients with chronic kidney disease (CKD ...
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PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
During an increase in work-related stress or physical activities, the power stations in our cells, the mitochondria, go into increased action and transform fat into energy.. The amino acid carnitine, the so called carrier of long-chained fat molecules, plays a very important role in transporting the right fats to the right places as it allows fats to be more easily assimilated into energy.. Arginine on the other hand is known for its circulatory functions and is therefore important for endurance, vigour and concentration.. euramin CLASSIC is a reliable, approved combination of the amino acids arginine, glutamine, carnitine and methionine, as well as other nutrients, which support the body during times of physical and mental stress, creating a foundation for well-being and vitality.. ...
Abstract: Arginine decreased cholesterol and triglyceride content in blood sera of intact rats and inhibited the development of hyperlipidemia provoked by Triton WR-1339 injection. In rabbits pretreated with cholesterol arginine diminished the content of blood serum cholesterol and triglycerides. Introduction of arginine to intact and hyperlipidemic guinea pigs decreased the VLDL and increased the HDL level. Under influence of arginine electrophoretic zone of HDL apo A-1 was more pronounced and apo E zone became less distinct in hyperlipidemic guinea pigs ...
Bile duct ligation (BDL)-treated rats exhibit cholestasis, increased systemic oxidative tension, and liver fibrosis, which ultimately lead to liver cirrhosis. levels by postnatal day time 2 (~0.66 M) [5]. In children, plasma ADMA levels are higher than those in adults, and gradually Dabrafenib diminish from birth until around 25 years of age, having a mean decrease of 15 nM per year [6C8]. A healthy adult generates 300 mol (~60 mg) of ADMA per day [9]. Bode-Bogers found a significant increase in plasma levels of ADMA in subjects more than 70 years [10]. By inhibiting NO bioavailability, ADMA causes endothelial dysfunction, vasoconstriction, blood pressure elevation and atherosclerosis [11C16]. Increasing evidence reveals that elevated ADMA is associated with many diseases such as peripheral arterial disease, coronary artery disease, preeclampsia, hypertension, heart stroke, heart failing, chronic kidney disease, portal hypertension in cirrhosis, diabetes mellitus, and insulin level of resistance ...
L-Citrulline Malate: A compound consisting of Citrulline, a nonessential amino acid. It plays a vital role in many important biological processes including regulating nitric oxide production, helping to eliminate the burn associated with lactic acid build up, reducing the negative effects of ammonia and bacterial endo toxins on performance, increasing the rate of muscle ATP (Andenosine Triphosphate, the major energy source within the cell) production during exercise and greater phosphocreatine recovery after exercise. In fact, L-Citrulline Malate seems to increase plasma Arginine levels better than taking the amino acid Arginine itself! If the enhanced pumps and improved nutrient delivery properties are the reason you are using Arginine based NO products, you need to pay close attention to L-Citrulline Malate as this may result in muscles that can keep on going and going…completely smashing the aerobic threshold ...
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What is Arginine?. The amino acid Arginine (l-Arginine HCl) is acquiring a reputation for keeping the bodys biggest muscle, the heart, in tip-top shape. In addition to the heart, Arginine can also needed to increase protein synthesis which can in turn increase cels. Studies have found that men with low sperm counts experienced an increase in the number of sperm when they were supplemented with Arginine. How does it work?. Arginine supplements appear to reduce mildly elevated blood pressure by enhancing the synthesis of Nitric Oxide (a gas) in the cells lining the blood vessels. This helps dilate vessel walls and improves blood flow around the heart. In fact, Nitric Oxide ranks as the bodys most potent blood vessel expander. In addition, Arginine may help in treating male fertility caused by circulation problems. Where does it come from?. Arginine is an amino acid found in many foods, including dairy products, meat, poultry, fish, nuts and chocolate. Safety / Side Effects. Arginine has so far ...
Asymmetric dimethylarginine endogenous inhibition of nitric oxide synthase causes differential vasculature effects - Add Comment #878171
The current study confirms previous observations of our group and others that oxidized lipoprotein increases the endothelial release of ADMA and that ADMA reduces the synthesis of NO while increasing the generation of superoxide anion. However, in this study it took rather high concentrations (10 μm) of exogenous ADMA to have a measurable effect upon NO synthesis, superoxide anion generation and endothelial adhesiveness. This concentration of ADMA is at the upper range of plasma ADMA levels observed in disease (2 to 10 μm).. However, chronic exposure to the lower levels of ADMA observed in disease states appears to have similar effects on endothelial biology as does short-term exposure to the higher dose used in this study. Specifically, we and others have demonstrated that the two to three-fold increase in plasma ADMA observed in hypercholesterolemic individuals is associated with reductions in endothelium dependent vasodilation and urinary nitrate excretion-effects that are reversed by ...
Agmatine can regulate nitric oxide levels, which leads to the pump often felt at the gym after taking pre workout supplements containing this ingredient.*. Citrulline is another supplement which raises plasma arginine concentration. Its unknown whether citrulline and agmatine taken together further enhance systemic nitric oxide production.* Some research suggests that they compete for uptake, so its likely not worthwhile to combine arginine and citrulline. Other supplements that do not go well with agmatine include creatine, DAA, and Yohimbine. Read more about these interactions at Examine.com.. ...
Dietary arginine supplementation alters the catabolism of fat and amino acids in the whole body, enhances protein synthesis in skeletal muscle, and modulates intestinal microbial metabolism in growing pigs.
Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus Academic Article Article ...
NO is biosynthesized from the amino acid arginine, meaning increased consumption of arginine ought to boost greater production of NO. However, arginine is poorly absorbed by the intestine and is quickly broken down by the liver, which reduces its capacity to increase NO production and making it a poor choice for increasing NO. On the other hand, the amino acid citrulline, which is quickly converted in the body into arginine, is more effectively absorbed by the intestines and avoids breakdown by the liver. Consequently, taking AML Preworkout, which contains citrulline (as citrulline-malate), represents a fantastic way to vigorously increase endogenous arginine levels and drive NO production for considerably improved stamina. AML Preworkout does not contain agmatine (Decarboxilated form of arginine), which may inhibit NO production ...
Ive been taking L-ARGININE for about a month now about 2000mg a day, and at first the effects were great. Rock hard erections, shorter recovery time...
Read on and youll be able t answer the question Is too much salt bad for you? Does Arginine Make You Gain Weight Effects Creatine Side Disruptions in Blood Sugar Levels - Low Blood Sugar/Hypoglycemia: can indicate problems with the liver or kidneys and can lead to Effect of oral l-arginine supplementation on blood pressure: A an erection longer than 4 hours free pills ed samples meta-analysis of randomized double-blind placebo-controlled trials e) As it helps in vasodilation it also prevents abnormal blood clotting to a significant extent . V-12 by SAN incorporates 4 the same way that N-Acetyl-L-Glutamine is a major improvement over regular glutamine Nitroarginine is a significant advancement past regular l-arginine. Directions For Beverly Int. L arginine for fioids - Gnld Products For Fioid - Buy Fioids Product on Alibaba.. Arginine plays a role in the synthesis of hormones Does Arginine Make You Gain Weight Effects Creatine Side such as insulin and growth hormone and The strain showed a ...
Lüneburg N, Lieb W, Zeller T, Chen MH, Maas R, Carter AM, Xanthakis V, Glazer NL, Schwedhelm E, Seshadri S, Ikram MA, Longstreth WT Jr, Fornage M, König IR, Loley C, Ojeda FM, Schillert A, Wang TJ, Sticht H, Kittel A, König J, Benjamin EJ, Sullivan LM, Bernges I, Anderssohn M, Ziegler A, Gieger C, Illig T, Meisinger C, Wichmann HE, Wild PS, Schunkert H, Psaty BM, Wiggins KL, Heckbert SR, Smith N, Lackner K, Lunetta KL, Blankenberg S, Erdmann J, Münzel T, Grant PJ, Vasan RS, Böger RH. Genome-Wide Association Study of L-Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine. Circ Cardiovasc Genet. 2014 ...
L-Arginine capsules contain 700 mg pure, crystalline L-arginine. L-arginine is a conditionally essential dibasic amino acid. It is needed for tissue protein synthesis and ammonia detoxification via urea acid cycle. L-arginine can either be used for glucose synthesis or catabolized to produce energy via the tricarboxylic acid cycle. L-arginine is required for the synthesis of creatine phosphate which functions as a carrier of readily available energy for contractile work in muscles. L-arginine is also a precursor of polyamines, including putrescine, spermine and spermidine that act as physiological growth regulators of cell proliferation, and are involved in the stabilization of cell membranes and cell organelles. L-arginine is a potent stimulator of insulin, glucagon, and growth hormone release, and functions as a representative signal to the endocrine system that dietary protein ingestion has taken place.
Low prices on L-Arginine! Improve heart health, lower blood pressure and speed up wound healing*. L-arginine is an amino acid shown to have many benefits on health. Studies have shown significant improvement of symptoms as well as objective measurements of heart function. L-arginine improves the bioavailability of nitric oxide (NO), a naturally occurring substance in the body.
arolinska Institute in Sweden found that NO could be generated from nitrates that were abundant in green leafy vegetables like spinach, lettuce, kale and especially beetroot. This requires the activation of the NOx 3,2,1 pathway to be fully operational. In effect, nitrates consumed in foods are reduced by oral bacteria into nitrites and then in the stomach into NO.. Since then, other research groups have joined the effort to uncover nitrates amazing ability to generate NO that is quicker and much more efficient than the previously known pathway via the amino acid l-arginine. Unlike, l-arginine which is only operational in conditions with good oxygen and is dependent on the proper functioning of a family of enzymes called nitric oxide synthases (NOS), nitrates offer an alternate pathway (albeit a backup) for the body to generate the versatile NO molecule quickly at low doses and in low oxygen conditions! The latter is an important factor especially during a number of pathologies where oxygen is ...
BACKGROUNDSepsis leads to a complex systemic response of cytokines (both pro- and anti-inflammatory) and more recently recognized adipokine mediators. Endothelial nitric oxide (NO) may be a key component in regulating this response, but the pharmacologic manipulation of endothelial NO via L-arginine supplementation or inhibitors has provided inconsistent clinical data related to outcomes. These failures are related to the metabolism of L-arginine in the liver, toxicity of L-arginine, and asymmetric dimethylarginine inhibition, all of which may explain the arginine paradox. L-citrulline (CIT) offers a potentially valuable means of supplementing arginine and therefore impacting favorably NO availability. The goal of this study was to determine whether CIT supplementation altered the systemic response of mediators and cytokines in a rat model of sepsis with varying degrees of severity.METHODSSepsis was induced with 2 models of cecal ligation and puncture (CLP) of varying severity in Wistar rats. ...
Doctors Best L-Arginine delivers 1000mg L-arginine in a bilayer tablet, providing 500 mg of sustained release and 500 mg of immediate release L-arginine.
Doctors Best L-Arginine delivers 1000mg L-arginine in a bilayer tablet, providing 500 mg of sustained release and 500 mg of immediate release L-arginine.
Much like remaining calm, doctors have also noted that a proper diet is effective at improving your rate of healing. Similarly, people should try to add more nutrients and vitamins into their daily health routine. The amino acid arginine features a compound called nitric oxide, and increased levels have proven to bolster both your bloods oxygenation levels and overall circulation. Glutamine - one of the 20 or so essential amino acids that create the human genetic code - provides your body with substrate, a molecule thats essential for tissue growth. Both amino acids can be found in supplements like L-glutamine and L-arginine, but always consult with a physician before you begin take any supplement.. Article provided by Advanced Tissue. Click here to visit their website. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
The amino acid L-arginine together with its metabolites and related substances is in the center of many biologically important pathways, especially the urea cycle and the nitric oxide (NO) synthesis. Therefore, the concentrations of these substances in various biological fluids are of great interest …
Haydens investigation of variation within the ABCA1 gene was prompted by the finding that Tangier disease, characterized by almost a complete absence of HDL-C, is caused by a defect in ABCA1. This led Haydens team to search for other variants of the cholesterol transporter gene that might modify the risk of heart disease.. The researchers identified 16 single nucleotide polymorphisms (SNPs) a specific type of variation within the coding region of the ABCA1 gene. Of these, 10 caused amino acid changes in the protein, which have the potential to alter the function of the transporter. In the R219K variant the amino acid arginine is replaced with lysine. The authors note that the SNPs tend to be concentrated away from the functional regions of the transporter protein. They suggest that this may be why most variations seem to exert such minor effects. Defective ABC transporters have been implicated in a number of diseases: ABCA1 in Tangier disease, ABCC7, which transports chloride ions, in cystic ...
Arginine methylation[edit]. What was said above of the chemistry of lysine methylation also applies to arginine methylation, ... Arginine citrullination[edit]. Enzymes called peptidylarginine deiminases (PADs) hydrolyze the imine group of arginines and ... and some protein domains-e.g., Tudor domains-can be specific for methyl arginine instead of methyl lysine. Arginine is known to ... Salt bridges and hydrogen bonds between side chains of basic amino acids (especially lysine and arginine) and phosphate oxygens ...
Arginine catabolic mobile element[edit]. The arginine catabolic mobile element (ACME) is a virulence factor present in many ... "Arginine catabolic mobile element encoded speG abrogates the unique hypersensitivity of Staphylococcus aureus to exogenous ... "Epidemiologic distribution of the arginine catabolic mobile element among selected methicillin-resistant and methicillin- ...
The gene product of argR, ArgR an aporepressor, and arginine as a corepressor affect the operon of arginine biosynthesis. The ... Proline and arginine are derived from glutamate. Serine, formed from 3-phosphoglycerate, is the precursor of glycine and ... Arginine synthesis also utilizes negative feedback as well as repression through a repressor encoded by the gene argR. ... In addition, the amino acids arginine, cysteine, glycine, glutamine, histidine, proline, serine, and tyrosine are considered ...
Arginine. 1.545 g. Histidine. 0.726 g. Alanine. 1.436 g. Aspartic acid. 2.200 g. ...
Arginine. 2.086 g. Histidine. 0.389 g. Alanine. 0.662 g. Aspartic acid. 1.368 g. ...
Arginine. 2.446 g. Histidine. 0.557 g. Alanine. 1.027 g. Aspartic acid. 2.911 g. ...
Arginine. 1.516 g. Histidine. 0.255 g. Alanine. 0.509 g. Aspartic acid. 1.222 g. ...
Arginine. 4.550 g. Histidine. 0.969 g. Alanine. 1.528 g. Aspartic acid. 3.662 g. ...
Arginine*. 4.356. 9.263 g 3.989 g. 7.106 g. 13.245 g. 9.981 g. 8.253 g. 7.216 g. 15.8 g. 2.764 g. 3.7 g. 5.945 g ...
Arginine. 0.755 g. Histidine. 0.298 g. Alanine. 0.700 g. Aspartic acid. 1.264 g. ...
Arginine. 4.147 g. Histidine. 1.085 g. Alanine. 4.515 g. Aspartic acid. 5.793 g. ...
Arginine. 0.173 g. Histidine. 0.067 g. Alanine. 0.161 g. Aspartic acid. 0.417 g. ...
Arginine. 1.099 g. Histidine. 0.416 g. Alanine. 0.836 g. Aspartic acid. 1.550 g. ...
Arginine. 0.546 g. Histidine. 0.077 g. Alanine. 0.170 g. Aspartic acid. 0.325 g. ...
Arginine. 1.060 g. Histidine. 0.389 g. Alanine. 0.799 g. Aspartic acid. 1.261 g. ...
Arginine Arg R MT-TR 10,405-10,469 L Asparagine Asn N MT-TN 5,657-5,729 H ...
Arginine (≈12.5). *Histidine (≈6.1). Negative charge (pKa). *Aspartic acid (≈3.9) ...
Nω-Methyl-L-arginine (L-NMA). *Nω-Propyl-L-arginine (L-NPA) ...
... has been used as a food acidulant since 1946. It is approved for use as a food additive in the EU,[3] USA[4] and Australia and New Zealand.[5] As a food additive, it is used as an acidity regulator and can be denoted by the E number E297. It is generally used in beverages and baking powders for which requirements are placed on purity. Fumaric acid is used in the making of wheat tortillas as a food preservative and as the acid in leavening.[6] It is generally used as a substitute for tartaric acid and occasionally in place of citric acid, at a rate of 1 g of fumaric acid to every ~1.5 g of citric acid, in order to add sourness, similarly to the way malic acid is used. As well as being a component of some artificial vinegar flavors, such as "Salt and Vinegar" flavored potato chips,[7] it is also used as a coagulant in stove-top pudding mixes. The European Commission Scientific Committee on Animal Nutrition, part of DG Health, found in 2014 that fumaric acid is "practically non-toxic" ...
Arginine (≈12.5). *Histidine (≈6.1). Negative charge (pKa). *Aspartic acid (≈3.9) ...
Nω-Methyl-L-arginine (L-NMA). *Nω-Propyl-L-arginine (L-NPA) ...
Nω-Methyl-L-arginine (L-NMA). *Nω-Propyl-L-arginine (L-NPA) ...
... along with other amino acids such as proline and arginine, takes part in deamination, a process in which its amino group is ... "ON THE SEPARATION OF HISTIDINE AND ARGININE IV. THE PREPARATION OF HISTIDINE". Journal of Biological Chemistry. 78 (3): 627- ...
... converts arginine to citrulline and nitric oxide (NO).[1] Nitric oxide can diffuse through the plasma membrane into ... N-propyl-L-arginine), which acts on a different site.[6] ...
Arginine (≈12.5). *Histidine (≈6.1). Negative charge (pKa). *Aspartic acid (≈3.9) ...
Arginine (≈12.5). *Histidine (≈6.1). Negative charge (pKa). *Aspartic acid (≈3.9) ...
Chemical structure of the arginine vasopressin (argipressin) with an arginine at the 8th amino acid position. Lysine ... has a lysine in place of the arginine as the eighth amino acid, and is found in pigs and some related animals, whereas arginine ... Vasopressin, also named antidiuretic hormone (ADH), arginine vasopressin (AVP) or argipressin,[5] is a hormone synthesized as a ... There may be a connection between arginine vasopressin and autism.[34] Deficiency[edit]. Decreased AVP release (neurogenic - i. ...
... arginine; vitamin D; bedaquiline. These drugs are listed here either because they are not very effective (e.g., clarithromycin ...
200 mg arginine; 50 mg each asparagine, cystine, leucine, and isoleucine; 40 mg lysine hydrochloride; 30 mg serine; 20 mg each ...
In addition, non-polar interactions are made between protein side-chains and the deoxyribose groups, and an arginine side-chain ... Common modifications include acetylation, methylation, or ubiquitination of lysine; methylation of arginine; and ...
First isolated from animal horn (1895), arginine plays an important role in mammals in the synthesis of urea, the principal ... arginine, an amino acid obtainable by hydrolysis of many common proteins but particularly abundant in protamines and histones, ... arginine, an amino acid obtainable by hydrolysis of many common proteins but particularly abundant in protamines and histones, ... Arginine is one of several nonessential amino acids for adult mammals; i.e., they can synthesize it from glutamic acid and do ...
... arginine (CHEBI:29016). D-arginine (CHEBI:15816) is a arginine (CHEBI:29016). L-arginine (CHEBI:16467) is a arginine (CHEBI: ... arginine (CHEBI:29016) is a α-amino acid (CHEBI:33704) arginine (CHEBI:29016) is a guanidines (CHEBI:24436) arginine (CHEBI: ... arginine (CHEBI:29016) is conjugate acid of argininate (CHEBI:32695) arginine (CHEBI:29016) is conjugate base of argininium(1+ ... arginine residue (CHEBI:32700) is substituent group from arginine (CHEBI:29016). arginyl group (CHEBI:22619) is substituent ...
histone-arginine N-methyltransferase activity. • protein-arginine N-methyltransferase activity. • protein-arginine omega-N ... peptidyl-arginine methylation, to symmetrical-dimethyl arginine. • chromatin organization. • histone arginine methylation. ... "Entrez Gene: PRMT5 protein arginine methyltransferase 5".. *^ Stopa N, Krebs JE, Shechter D (June 2015). "The PRMT5 arginine ... Protein arginine N-methyltransferase 5 is an enzyme that in humans is encoded by the PRMT5 gene.[5][6] PRMT5 symmetrically ...
DESCRIPTION: The arginine content of nuts may explain their metabolism boosting effects, though in a list of the top food ... Arginine Does Not Work Unless....... - Duration: 6:20. Tim Muriello 13,076 views ... L-Arginine Benefits For Bodybuilding? - Duration: 4:25. Sean Nalewanyj 104,294 views ... Nobel Prize winner talks about ARGI+ L-arginine supplement - Duration: 4:53. Katalin Hidvegi 70,978 views ...
L-arginine is an amino acid naturally found in red meat, poultry, fish, and dairy. It is necessary for making proteins and is ... Arginine Hydrochloride, Di-Arginine Malate, Di-Arginine Orotate, Di-L-Arginine-L-Malate, Dl-Arginine, L-Arginina, L-Arginine ... Arginine, Arginine Aspartate, Arginine Ethyl Ester, Arginine Ethyl Ester Dihydrochloride, Arginine Ethyl Ester HCl, Arginine ... L-Arginine L-Pyroglutamate, L-Arginine Pyroglutamate, L-Arginine Taurinate, Malate de Di-Arginine, Orotate de Di-Arginine, R- ...
... l arginine ed treatment 2014, best male enhancement extenders ucla, ed sheeran tattoo paw ... Arginine capsules allow for a quick and convenient way for bodybuilders and athletes to provide extra essential arginine pre- ... L-Arginine is an essential amino acid necessary in the synthesis of nitric oxide, hormone production, optimal function of the ... Arginine facilitates the creation of nitric oxide, which helps the blood carry more nutrients and more oxygen to working ...
Arginine isnt assembled by the body, so it... ... Sources of arginine include: *brown rice *nuts *popcorn * ... Arginine isnt assembled by the body, so it must be ingested, especially by people at a young age. ... structural formula for arginine: _ _ , H H , + , \ / , , N H H H H O , , \\ \ / \ / // , , C -- N -- C -- C -- C -- C -- C ... H -- N H H H H N O -- H , , / / \ , , H arginine H H , ,_ C6H15N4O2+ _, ...
... but additional dietary arginine is needed during periods of growth, as in childhood or during pregnancy, and possibly during ... Arginine is usually synthesized by adults in amounts sufficient to maintain the body proteins, ... L-arginine and L-ornithine, or L-arginine and L-lysine, can be supplemented at 500-1000 mg. of each twice daily, or 1000 to ... Arginine deficiency can result in hair loss, constipation, a delay in the healing of wounds, and liver disease.. Arginine has ...
Arginine:glycine amidinotransferase deficiency is an inherited disorder that primarily affects the brain. Explore symptoms, ... glycine, arginine, and methionine. Specifically, arginine:glycine amidinotransferase controls the first step of the process. In ... Children with arginine:glycine amidinotransferase deficiency may not gain weight and grow at the expected rate (failure to ... The prevalence of arginine:glycine amidinotransferase deficiency is unknown. The disorder has been identified in only a few ...
Arginine definition, an essential amino acid, C 6 H 14 N 4 O 2 : the free amino acid increases insulin secretion and is ... arginine in Medicine Expand. arginine ar·gi·nine (ärjə-nēn). n. Abbr. Arg An amino acid obtained from the hydrolysis or ... First recorded in 1885-90, arginine is from the German word Arginin, a name unexplained by its originators ... In vertebrates, the basis for the phosphoric acid is creatine, whereas invertebrates have arginine instead. ...
ARGININE, L-A-AMINO-D -GUANIDINOVALERIC ACID, L-ARGININE, L-NORVALINE, 5-((AMINOIMINOMETHYL)AMINO)-, L-ORNITHINE, N5-( ... Arginine is a naturally occurring amino acid.. (S)- PENTANOIC ACID, 2-AMINO-5-((AMINOIMINOMETHYL)AMINO)-, 2-AMINO-5-(( ...
ARGININE; L- (+) -ARGININE; L-ARGININE; L-ORNITHINE, N5- (AMINOIMINOMETHYL) - ... About ARGININE: Arginine is a naturally occurring amino acid.. Function(s): Fragrance Ingredient; Hair Conditioning Agent; Skin ... Synonym(s): L-A-AMINO-D -GUANIDINOVALERIC ACID; L-ARGININE; L-ORNITHINE, N5- (AMINOIMINOMETHYL) -; N5- (AMINOIMINOMETHYL) - L- ...
Previous research has suggested that levels of arginine are reduced in patients with depression compared to persons who are not ... in patients with MDD and found lower arginine levels and a lower global arginine bioavailability ratio (GABR) in those with MDD ... However, "as lower arginine levels have been previously reported to be associated with higher cardiovascular risks, patients ... GABR is calculated as the serum level of arginine divided by the sum of ornithine plus citrulline. This calculation yields a ...
... or L-arginine, is one of the 20 amino acids we get from proteins. Its typically considered a semi-essential amino acid. Find ... What is arginine?. Arginine, or L-arginine, is one of 20 amino acids that you get from proteins in your diet. Its typically ... What does arginine do?. Your body uses arginine to synthesize nitric oxide. Nitric oxide helps your blood vessels relax and ... Taking arginine supplements may make some health issues worse. Always talk to your doctor before adding arginine supplements to ...
ink that L-arginine might be the most disputed conception aid. Some sources state it improves quantity of eggs but decreases ... L-arginine and conception. I think that L-arginine might be the most disputed conception aid. Some sources state it improves ... The authors found that the women who did not receive L-arginine supplmentation had the same L-arginine follicular levels as the ... L-arginine converts in the body to nitric oxide. Nitric oxide causes vasodilation, and that may help to increase blood flow to ...
Brands A-Z Source Naturals L-Arginine Categories Supplements Amino Acids L-Arginine Categories Sports Nutrition Post-Workout ... Source Naturals, L-Arginine 4 Results (showing 1 - 4) Visit Manufacturers Website » ...
Brands A-Z Carlson Labs L-Arginine Categories Supplements Amino Acids L-Arginine Categories Sports Nutrition Post-Workout ...
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
L-arginine) to improve heart health. Find out where it comes from, if supplementation works, and its possible side effects. ... Why Do We Need Arginine?. Arginine, also known as L-arginine, is involved in a number of different functions in the body. They ... What Are Arginines Heart Benefits?. In the body, the amino acid arginine changes into nitric oxide (NO). Nitric oxide is a ... Is Arginine Supplementation Safe?. In clinical trials, arginine has been used safely with minor side effects for up to three ...
The L-arginine-nitric oxide pathway.. Moncada S1, Higgs A.. Author information. 1. Wellcome Research Laboratories, Beckenham, ...
Athletes and others seek out ways to boost their L-arginine intake. It may have some other health benefits, but its use can ... Learn about some natural ways to consume L-arginine and some side effects. ... L-arginine is an amino acid that helps the body to build proteins. ... L-arginine is one of many amino acids the body needs to function properly.. Like other amino acids, L-arginine plays a role in ...
... Renée C. Benson,1 Karen A. Hardy,1 and Claudia R. Morris2 ... Renée C. Benson, Karen A. Hardy, and Claudia R. Morris, "Arginase and Arginine Dysregulation in Asthma," Journal of Allergy, ...
Ask questions and get answers about L-Arginine. Our support group helps people share their own experience. 16 questions, 24 ... L-Arginine Patient Information at Drugs.com. *L-Arginine Information for Healthcare Professionals (includes dosage details) ... L-Arginine - Im interested in ProArgi-9 and want to know what effects the suplement will have with?. Posted 21 Dec 2010 • 1 ... L-Arginine - Is l-argenine safe to take if you have hypothyroidism caused from graves disease?. Posted 25 Jan 2010 • 1 answer ...
Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells ... 1: The butterfly effect of arginine methylation on the expression of and signaling via γc cytokine receptors.. ... Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance *Maia Inoue ... Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells ...
Arginine and Citrulline Catabolic Pathways Encoded by the arc Gene Cluster of Lactobacillus brevis ATCC 367 Maria Majsnerowska ... l-Lysine Catabolism Is Controlled by l-Arginine and ArgR in Pseudomonas aeruginosa PAO1 Han Ting Chou, Mohamed Hegazy, Chung- ... Two Essential Arginine Residues in the T Components of Energy-Coupling Factor Transporters Olivia Neubauer, Anja Alfandega, ... Role of the Twin-Arginine Translocation Pathway in Staphylococcus Lalitha Biswas, Raja Biswas, Christiane Nerz, Knut Ohlsen, ...
arginine vasopressin receptors (AVP-1B) in rat. Antigen has no significant simililarity with AVP V1a or V2 ...
This poster was presented today at the Association for Research in Vision and Opthalmology (ARVO) meetings in Ft. Lauderdale, Florida by W. Drew Ferrell, Lloyd Williams, Carl B. Watt, James R. Anderson, Robert E. Marc and Bryan William Jones. Full size (almost) poster can be seen here.. ...
... user ratings and products that contain L-Arginine ... Learn more about L-Arginine uses, effectiveness, possible side ... Arginine Hydrochloride, Di-Arginine Malate, Di-Arginine Orotate, Di-L-Arginine-L-Malate, Dl-Arginine, L-Arginina, L-Arginine ... L-Arginine L-Pyroglutamate, L-Arginine Pyroglutamate, L-Arginine Taurinate, Malate de Di-Arginine, Orotate de Di-Arginine, R- ... Arginine, Arginine Ethyl Ester, Arginine Ethyl Ester Dihydrochloride, Arginine Ethyl Ester HCl, Arginine HCl, ...
Make research projects and school reports about arginine easy with credible articles from our FREE, online encyclopedia and ... Arginine is one of the amino acids produced in the human body by the digestion, or hydrolysis of proteins. Arginine can also be ... "Arginine and Exercise." Better Nutrition (June 2000).. Chowienczyk, Phil and Jim Ritter. "Arginine: NO more than a simple amino ... Arginine is necessary for growth periods but not for body maintenance.. Benefits of the use of arginine as a supplement include ...
  • Finnish investigators studied serum levels of three amino acids - arginine, citrulline, and ornithine - in patients with MDD and found lower arginine levels and a lower global arginine bioavailability ratio (GABR) in those with MDD in comparison with control participants who did not have MDD. (medscape.com)
  • GABR is calculated as the serum level of arginine divided by the sum of ornithine plus citrulline. (medscape.com)
  • L-arginine Plus combines the amino acids l-arginine and l-citrulline in a great-tasting powder drink mix that has been helping people for more than 10 years. (chiroeco.com)
  • Many men are now taking L-Arginine and/or L-Citrulline in order to boost blood L-Arginine levels, which in turn increases the amount of all-important nitric oxide in the blood. (apsense.com)
  • However, what is not commonly realized is that increasing Arginine levels, through Arginine or Citrulline, could feed and fuel certain herpes viruses and actually damage one's long term health. (apsense.com)
  • Boosting blood flow is why MyHealthDriver created EnerFlex Forte 2.0 with Kyowa Quality® L-Citrulline and L-Arginine. (prweb.com)
  • L-Arginine is an amino acid critical to the production of NO. L-Citrulline is a major precursor to L-Arginine and has been shown in other studies to increase L-Arginine levels, and thus improve NO production. (prweb.com)
  • Together this combination of L-Citrulline and L-Arginine delivers a powerful boost to overall arginine levels. (prweb.com)
  • Adding Kyowa Quality® L-Citrulline and L-Arginine to EnerFlex Forte 2.0 provides a nitric oxide boost to help increase peripheral and central blood flow. (prweb.com)
  • Kyowa Hakko received a patent in 2014 for a combination of L-Citrulline and L-Arginine that can quickly increase blood arginine levels compared to individual amino acids. (prweb.com)
  • According to the patent, this combination "increases blood flow within 1 hour and 40 minutes…compared to Citrulline or Arginine alone. (prweb.com)
  • Other research also shows a partnering of L-Citrulline and L-Arginine can have beneficial effects on the body. (prweb.com)
  • A study recently published in the American College of Sports Medicine shows oral supplementation with L-Citrulline before exercise may help reduce gastrointestinal problems associated with physical strain by increasing L-Arginine levels - resulting in better NO production - that provide increased circulation to abdominal and intestinal areas. (prweb.com)
  • And a related study on rats and rabbits published in September in Biochemical and Biophysical Research Communications showed L-Citrulline plus L-Arginine supplementation caused a more rapid increase in plasma L-Arginine levels and marked enhancement of NO bioavailability, including plasma cGMP concentrations, than with dosage with the single amino acids. (prweb.com)
  • Each sachet of EnerFlex Forte 2.0 includes 750mg of Kyowa Quality® L-Citrulline and 250mg of L-Arginine. (prweb.com)
  • L-Citrulline is converted to L-Arginine in the body, leading to sustained increases in both L-Arginine and nitric oxide. (prweb.com)
  • In this article, we are going to learn more about two natural substances - L-Arginine and L-Citrulline and their efficacy in erectile dysfunction treatment. (verichipcorp.com)
  • We are talking about two important amino acids: L-Arginine and L-Citrulline. (verichipcorp.com)
  • What are L-Arginine and L-Citrulline amino acids? (verichipcorp.com)
  • Arginine and Citrulline are one of them. (verichipcorp.com)
  • L-Citrulline is another semi-essential amino acid, it is able to transform to L-Arginine. (verichipcorp.com)
  • L-Citrulline is able to enter the kidneys and increase the plasma L-Arginine concentration and to augment NO-dependent signaling. (verichipcorp.com)
  • A cross-over study proved that L-Citrulline performs that more effectively in comparison with L-Arginine. (verichipcorp.com)
  • The scientists were encourage to find no adverse effects from supplementation with L-Arginine and L-Citrulline in the dosages specified in the instruction. (verichipcorp.com)
  • One of the most outstanding findings of the overall research conducted with L-Arginine and L-Citrulline is that L-Citrulline intake corrects the cause of ED, the PDE5 inhibitors (for example, popular Viagra, Levitra, Cialis) do not. (verichipcorp.com)
  • All these factors let us resume that proper L-Arginine and L-Citrulline supplementation can manage and even treat penile endothelial dysfunction and help in dealing with ED. (verichipcorp.com)
  • Arginine is synthesized from citrulline by the sequential action of the cytosolic enzymes argininosuccinate synthetase (ASS) and argininosuccinate lyase (ASL). (wikidoc.org)
  • On a whole-body basis, synthesis of arginine occurs principally via the intestinal-renal axis , wherein epithelial cells of the small intestine , which produce citrulline primarily from glutamine and glutamate , collaborate with the proximal tubule cells of the kidney , which extract citrulline from the circulation and convert it to arginine, which is returned to the circulation. (wikidoc.org)
  • Synthesis of arginine from citrulline also occurs at a low level in many other cells, and cellular capacity for arginine synthesis can be markedly increased under circumstances that also induce iNOS . (wikidoc.org)
  • Thus, citrulline, a coproduct of the NOS-catalyzed reaction, can be recycled to arginine in a pathway known as the citrulline-NO or arginine-citrulline pathway . (wikidoc.org)
  • This is demonstrated by the fact that in many cell types, citrulline can substitute for arginine to some degree in supporting NO synthesis. (wikidoc.org)
  • Incorporated in proteins, arginine can also be converted to citrulline by PAD enzymes. (wikidoc.org)
  • Arginine and Citrulline are two amino acids that are integral to protein metabolism and utilization, as well as to the maintenance of muscle tissue. (fredmeyer.com)
  • Scientific studies have shown that supplementing Citrulline along with Arginine helps maintain nitrogen balance better than supplementation with Arginine alone. (fredmeyer.com)
  • The concentrations of three amino acids, namely arginine, citrulline and ornithine, were analysed from their fasting glucose samples, and this data was used to calculate their global arginine bioavailability ratio (GABR). (indianexpress.com)
  • Nitric oxide (NO) and the by-product citrulline are synthesised from the amino acid L-arginine by NO-synthases (NOS), which exist in three isoforms. (diva-portal.org)
  • We demonstrate that patients with acute pancreatitis, whatever the cause, have reduced sermn levels of arginine and citrulline, indicating a disturbed NO metabolism with possible negative effects on the outflow of pancreatic juice and on pancreatic blood perfusion. (diva-portal.org)
  • Sermn arginine and citrulline increased at 8 hours, but fell below control levels, at 24 hours. (diva-portal.org)
  • Ornithine is synthesized from Arginine and is a precursor of citrulline, proline and glutamic acid. (a1supplements.com)
  • Body builders supplement L-arginine along with L-ornithine for its muscle-building effects. (healthy.net)
  • L-arginine and L-ornithine, or L-arginine and L-lysine, can be supplemented at 500-1000 mg. of each twice daily, or 1000 to 1500 mg. of each before bed. (healthy.net)
  • This enzyme participates in 3 metabolic pathways: lysine degradation, D-glutamine and D-glutamate metabolism, and D-arginine and D-ornithine metabolism. (wikipedia.org)
  • Supplements that combine arginine with other amino acids, such as ornithine and lysine , are purported to assist in muscle-building exercises by minimizing body fat and maximizing muscle tone. (encyclopedia.com)
  • In addition, arginine is converted to another amino acid called ornithine and substances called polyamines. (livestrong.com)
  • Serum ornithine level was high (622 μ mol/L). An arginine-restricted diet reduced serum ornithine level (55 μ mol/L). However, visual findings including macular edema remained unchanged in 2 years of follow-up. (hindawi.com)
  • After starting to consume an arginine-restricted diet, serum ornithine level reduced within two months (55 μ mol/L). His serum ornithine concentrations were well controlled during the last 22 months over 2-year follow-up. (hindawi.com)
  • L-Arginine and L-Ornithine are non-essential amino acids with similar structure and function. (vitacost.com)
  • Now Arginine & Ornithine - 500mg L-Arginine & 250mg L-Ornithine Per Capsule! (a1supplements.com)
  • Arginine and Ornithine combines two essential amino acids into one optimal supplement. (a1supplements.com)
  • arginine , an amino acid obtainable by hydrolysis of many common proteins but particularly abundant in protamines and histones , proteins associated with nucleic acids . (britannica.com)
  • Arginine is usually synthesized by adults in amounts sufficient to maintain the body proteins, but additional dietary arginine is needed during periods of growth, as in childhood or during pregnancy, and possibly during times of stress. (healthy.net)
  • Additionally, arginine fingers may be attached to different subunits or other proteins in a multiprotein complex. (wikipedia.org)
  • Arginine is one of the amino acids produced in the human body by the digestion, or hydrolysis of proteins. (encyclopedia.com)
  • Quantitative affinity proteomics using a ClpP-trapping mutant show that proteins phosphorylated on arginine residues are selectively targeted to ClpC-ClpP. (nature.com)
  • In vitro reconstitution experiments demonstrate that arginine phosphorylation by the McsB kinase is required and sufficient for the degradation of substrate proteins. (nature.com)
  • L-arginine is an amino acid that helps make proteins. (healthline.com)
  • The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway. (nih.gov)
  • Tudor domains are known to fulfill this function by binding to methylated PIWI proteins in an arginine methylation-dependent manner. (pnas.org)
  • Arginine is an amino acid that plays a role in the synthesis of proteins. (selfgrowth.com)
  • Jacques servier, coupon and l arginine viagra together four nonsurgical compounds risk such proteins of up to four services plus men. (recoveryrestart.com)
  • For this reason arginine prefers to be on the outside of the proteins where it can interact with the polar environment. (wikidoc.org)
  • As a natural dietary supplement , arginine has garnered particular attention for its possible heart benefits. (webmd.com)
  • If taken as a supplement, higher doses of arginine are often needed, and up to 1200 mg per day have been shown to be helpful. (webmd.com)
  • Some people take L-arginine as a supplement. (medicalnewstoday.com)
  • It is essential for anyone interested in taking L-arginine as a supplement to talk to their doctor about the potential benefits and risks before starting to use it. (medicalnewstoday.com)
  • Arginine is also present in "multi" amino acids capsules that are taken as a dietary supplement. (encyclopedia.com)
  • L-arginine Plus is an amino acid supplement formulated to support healthy blood pressure and overall cardiovascular health. (chiroeco.com)
  • While L-arginine alone may not treat your ED, the combination of L-arginine and an herbal supplement called pycnogenol may help. (healthline.com)
  • Like any medication or supplement, L-arginine has several possible side effects. (healthline.com)
  • At first glance, L-arginine may seem like a hardcore bodybuilding supplement, only for weightlifters and strength-training athletes. (livestrong.com)
  • In his ongoing 20-year quest to find some relief for patients with peripheral arterial disease, or PAD, John Cooke, MD, discovered early on that arginine, an amino acid that can be given as a supplement, helped ease pain by relaxing arteries and increasing blood flow. (stanford.edu)
  • Cooke's earlier, short-term studies of the supplement had shown arginine reduced symptoms in people with heart and vessel disease. (stanford.edu)
  • Other medical professionals are still recommending arginine as a supplement to their heart patients, but Cooke no longer does. (stanford.edu)
  • Pre-eclampsia, which affects approximately 1 in every 20 first time pregnancies, could be prevented if high risk pregnant women started taking a dietary supplement containing L-arginine and antioxidant vitamins during their 20th week of pregnancy, researchers from La Universidad Nacional Autonoma de Mexico, Mexico City, reported in the BMJ (British Medical Journal) . (medicalnewstoday.com)
  • Scientists from Mexico and the USA wanted to determine whether a L-arginine plus antioxidant supplement could help reduce pre-eclampsia rates in high risk women. (medicalnewstoday.com)
  • To determine whether it is more cost-effective, the higher cost must be considered in relation to any additional caries-preventive effect of the arginine supplement. (sbu.se)
  • This is where an L-Arginine supplement may be needed. (hollandandbarrett.com)
  • Now L- arginine 500mg, is so indispensable in the sense that it is also an important supplement for the insulin in the body. (mynewsdesk.com)
  • You can grab Canadian supplements such as AOR L-Arginine from one of the best online supplement selling sites in Canada, Vitasave.ca. (mynewsdesk.com)
  • Jarrow® Arginine 1000 100 tabs is a supplement that can safely deliver significant levels of Arginine amino acid to help the body's production of nitric oxide, improve the blood flow through the body, and promote a healthy heart. (astronutrition.com)
  • Jarrow® Arginine 1000 100 tabs is a supplement that is able to deliver significant levels of L-Arginine to the body in a safe, natural way that is also suitable for vegetarians as it contains no wheat, gluten, soybeans, dairy, egg, fish or any common allergen. (astronutrition.com)
  • Although our study shows that people with depression have reduced arginine bioavailability, this doesn't mean that taking an arginine supplement would protect against depression. (indianexpress.com)
  • Other new research was finding that arginine supplements worked as an effective anticoagulant, but unlike aspirin and other anticoagulants, could prevent clotting without increasing stroke risk. (encyclopedia.com)
  • Arginine supplements as an alternative medicine therapy are normally taken in either tablet or capsule form. (encyclopedia.com)
  • Long-term effects of arginine supplements have not yet been determined. (encyclopedia.com)
  • A doctor may suggest arginine supplements for those suffering from conditions such as coronary heart disease, congestive heart failure, erectile dysfunction, high blood pressure or clogged arteries according to Healthline. (reference.com)
  • One of the more common supplements marketed to help treat ED is L-arginine. (healthline.com)
  • However, L-arginine is often combined with other supplements, which have different results. (healthline.com)
  • A study in the Journal of Sex and Marital Therapy found that L-arginine and pycnogenol supplements helped a significant number of men ages 25 to 45 with ED achieve normal erections. (healthline.com)
  • The cream can be used just prior to intercourse, whereas oral supplements containing l-arginine must be taken daily to be effective. (wisegeek.com)
  • For instance, arginine supplements should never be used while a patient is using any non-steroidal anti-inflammatory (NSAID) medications, because the combination can severely irritate the stomach. (wisegeek.com)
  • There are many benefits of arginine, according to the Nutritional Supplements Health Guide, including increased immune function, the ability to detoxify the liver, and increased fertility in men. (ehow.co.uk)
  • Like many patients with mitochondrial disease, nearly all patients in this cohort were already taking oral "mitochondrial cocktails" of vitamins and cofactor supplements, commonly including oral arginine, at the time of their stroke-like episode. (eurekalert.org)
  • Are There Arginine Supplements You Can Take? (selfgrowth.com)
  • Nevertheless, choose to "err on the side of caution" even when selecting natural arginine supplements. (selfgrowth.com)
  • Just like all other supplements and medicines, arginine certainly has its own arsenal of side effects. (selfgrowth.com)
  • Have you attempted taking arginine supplements in the past? (selfgrowth.com)
  • Patients with PAD were divided into two groups, given either arginine supplements or a placebo over a six-month period. (stanford.edu)
  • L-arginine supplementation, at a dosage of 4 grams daily, has been successful in improving fertility in men by increasing low sperm count and motility. (healthy.net)
  • Children and teenagers should avoid supplementation of L-arginine for growth stimulation or body building. (healthy.net)
  • Is Arginine Supplementation Safe? (webmd.com)
  • The February 2005 issue of "Nutrition in Clinical Practice" reports that arginine supplementation has been shown to enhance wound healing both in rodents and in humans. (livestrong.com)
  • L-arginine supplementation in women with chronic hypertension: impact on blood pressure and maternal and neonatal complications. (greenmedinfo.com)
  • Like other amino acids, L-arginine plays a role in building protein. (medicalnewstoday.com)
  • In addition to building protein, L-arginine releases nitric oxide in the blood. (medicalnewstoday.com)
  • L-arginine has two effects: it turns into nitric oxide and helps the body build protein. (medicalnewstoday.com)
  • Arginine fingers are often found in the protein superfamily of AAA+ ATPases, GTPases, and dUTPases, where they assist in the catalysis of the gamma phosphate or gamma and beta phosphates from ATP or GTP, which creates a release of energy which can be used to perform cellular work. (wikipedia.org)
  • One of these helicases, the Bloom syndrome protein, contains an arginine finger which assists in its hydrolysis of ATP. (wikipedia.org)
  • The best sources of foods for arginine are high protein foods. (ehow.co.uk)
  • Because dairy is a high protein food, it also contains a good amount of arginine. (ehow.co.uk)
  • Here, we show that CASTOR1, a previously uncharacterized protein, interacts with GATOR2 and is required for arginine deprivation to inhibit mTORC1. (nih.gov)
  • We used crystallography and biochemical studies to show that TDRD2 binds to PIWI-like protein 1 (PIWIL1) in an arginine methylation-independent manner. (pnas.org)
  • Unlike most other Tudor domains, the extended Tudor domain of mammalian Tudor domain-containing protein 2 (TDRD2) preferentially recognizes an unmethylated arginine-rich sequence from PIWI-like protein 1 (PIWIL1). (pnas.org)
  • Arginine is naturally produced in the body or broken down from certain protein-dense food we consume every day. (selfgrowth.com)
  • Bérard, MP, Zazzo, JF, Condat, P, Vasson, MP, Cynober, L 2000 Total parenteral nutrition enriched with arginine and glutamate generates glutamine and limits protein catabolism in surgical patients hospitalized in intensive care units. (springer.com)
  • Alcock F, Baker MA, Greene NP, Palmer T, Wallace MI, Berks BC (2013) Live cell imaging shows reversible assembly of the TatA component of the twin-arginine protein transport system. (springer.com)
  • Aldridge C, Storm A, Cline K, Dabney-Smith C (2012) The chloroplast twin arginine transport (Tat) component, Tha4, undergoes conformational changes leading to Tat protein transport. (springer.com)
  • Berks BC (2015) The twin-arginine protein translocation pathway. (springer.com)
  • Arginine is necessary for proper cell division, protein synthesis, recovery processes in the body and insulin resistance reduction. (verichipcorp.com)
  • Arginine vasopressin receptor 1B (AVPR1B, vasopressin 3 receptor) is a protein that acts as cell surface receptor for arginine vasopressin . (citizendium.org)
  • In addition, arginine can be methylated by protein methyltransferases. (wikidoc.org)
  • Arginine that has not been converted to urea enters general circulation where it is distributed to various tissues and metabolized for other uses such as protein synthesis. (fredmeyer.com)
  • The major type II protein arginine methyltransferase PRMT5 catalyzes the formation of symmetric dimethyl arginine and has been implicated in various cellular processes, including pluripotency and tumorigenesis. (jci.org)
  • L-Arginine becomes part of protein in the body. (vitacost.com)
  • Holland & Barrett L-Arginine provides 500mg of Arginine in each rapid release capsule. (hollandandbarrett.com)
  • That is more reason why you need Now L- Arginine 500mg to boost your health. (mynewsdesk.com)
  • So hence, to avoid this disorders it is important to use Now L-Arginine 500mg daily. (mynewsdesk.com)
  • Because there are no methods to directly and reliably measure levels of NO, the only possibility is to measure the bioavailability of arginine, which is its precursor and is also the limiting factor for the synthesis of NO. (medscape.com)
  • L-arginine is an amino acid, a growth hormone releaser, and a precursor to nitric oxide. (bio.net)
  • Once absorbed into the bloodstream, arginine acts as a precursor to nitric oxide or NO, which vasodilates, or expands, blood vessels. (livestrong.com)
  • Arginine and N-acetylcysteine, precursor and enhancer of the nitric oxide synthesis respectively, are able to increase nitric oxide production. (clinicaltrials.gov)
  • Arginine can serve as a nitric oxide precursor. (puritan.com)
  • L-Arginine is a precursor of nitric oxide, which is necessary for the healthy dilation of blood vessels, circulation, and blood flow. (carlsonlabs.com)
  • arginine vasopressin receptors (AVP-1B) in rat. (alzforum.org)
  • Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor. (citizendium.org)
  • Arginine vasotocin (AVT) is the non-mammalian homolog of arginine vasopressin (AVP) and, like vasopressin, serves as an important modulator of social behavior in addition to its peripheral functions related to osmoregulation, reproductive physiology, and stress hormone release. (frontiersin.org)
  • Amphibians and reptiles, like other non-mammalian vertebrates, express arginine vasotocin (AVT) rather than the arginine vasopressin (AVP) found in mammals. (frontiersin.org)
  • Amino acid sequence in vasopressin (top) found in mammals and arginine vasotocin (bottom) found in amphibians, reptiles, and other non-mammalian vertebrates. (frontiersin.org)
  • Most of the cardiovascular effects of l-arginine are mediated through the vascular endothelium. (infobarrel.com)
  • The antinociceptive effects of L-arginine in both diabetic and non-diabetic mice were significantly antagonized by s.c. administration of naltrindole, a selective delta-opioid receptor antagonist. (biomedsearch.com)
  • Since L-Arginine is the substrate for nitric oxide synthesis by vascular endothelial cells the effects of L-arginine treatment on the digital vascular response to local stimuli were investigated in patients with primary or secondary Raynaud's phenomenon. (nih.gov)
  • In human plasma and erythrocytes, irbesartan modulated L-arginine metabolism ( 224 ). (livingnaturally.com)
  • L-Arginine metabolism involves the production of nitric oxide (NO) which releases dopamine (among other things) in the brain. (patientslikeme.com)
  • NOW L-Arginine 500mgis basically involved in the metabolism of urea in the body, and also important for muscle builders. (mynewsdesk.com)
  • The arginine content of nuts may explain their metabolism-boosting effects-though, in a list of the top food sources of arginine, nuts don't even make the top ten. (nutritionfacts.org)
  • Arginine is necessary for urea metabolism, a process that prepares toxic ammonia for safe excretion by the kidneys. (a1supplements.com)
  • Discoveries reported in 2000 indicated that in the treatment of arterial heart disease, the ingestion of arginine tablets or capsules of 6 - 9 g a day are helpful in dilating blood vessels to ease circulation and prevent the buildup of cholesterol. (encyclopedia.com)
  • The name of your medicine is APO-Perindopril Arginine tablets. (news-medical.net)
  • In in buy l-arginine pharmacy same, a days, sometime general a pharmacies community dispense counter same tablets pharmacists, spend patients hers that compounded advice in you their their of and to giving the although also many and customers from obtain specialize drugs capsules non behind, against compounding, without that, too can although believe counting buy l-arginine. (quicktopic.com)
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  • Two tablets of Best L-Arginine delivers 1000mg L-arginine in a bilayer tablet, providing 500 mg of sustained release and 500 mg of immediate release L-arginine. (netrition.com)
  • Tablets contain perindopril arginine 3.5 mg, 7 mg, or 14 mg and amlodipine 2.5 mg, 5 mg, or 10 mg for the following available perindopril arginine/amlodipine combinations: 3.5/2.5 mg, 7/5 mg, and 14/10 mg. (rxlist.com)
  • Yohimbine hydrochloride, also known as yohimbine, is an approved treatment for ED. A 2010 study of the combination of L-arginine and yohimbine hydrochloride found the treatment shows some promise. (healthline.com)
  • The medicines below all contain the following active ingredient(s): arginine hydrochloride. (healthdirect.gov.au)
  • This article will show you how nitric oxide (a dangerous free radical) and L-arginine (an essential amino acid) are critical components to your sexual health. (selfgrowth.com)
  • Nitric oxide, synthesized from the essential amino acid L-arginine, in literally involved in all cells to help keep you fit and healthy. (selfgrowth.com)
  • L-Arginine is an essential amino acid, especially in children, and contributes to the production of the gas nitric oxide, which plays a crucial role in your cardiovascular system. (livestrong.com)
  • Arginine cream is a topical lotion that contains l-arginine , a semi-essential amino acid . (wisegeek.com)
  • Arginine is a non-essential amino acid. (ehow.co.uk)
  • L-Arginine is a non-essential amino acid which means it can be produced by the body as well as obtained through the diet. (hollandandbarrett.com)
  • L-Arginine is a semi-essential amino acid, i.e. the body is able to produce it from other amino acids and get directly from some products. (verichipcorp.com)
  • Arginine is considered a semi-essential amino acid. (netrition.com)
  • In mammals, arginine is classified as a semiessential or conditionally essential amino acid, depending on the developmental stage and health status of the individual. (wikidoc.org)
  • It is well-known that the essential amino acid, Arginine, makes a significant contribution to the body's production of nitric oxide, which improves the flow of blood through the body by dilating the vessels. (astronutrition.com)
  • We know that depression, as well as any other illness or disorder, has several physiological changes related to it, but just don't yet know all of them and how they are related to each other - although depression-induced inflammatory response may lead to reduced arginine levels," he said. (medscape.com)
  • It is possible that depression-induced inflammatory responses lead to reduced arginine levels. (indianexpress.com)
  • Individuals with major depressive disorder (MDD) have relatively low levels of arginine, which impairs production of nitric oxide (NO) and leads to an increase in oxidative stress, new research shows. (medscape.com)
  • L-arginine, available in 500 mg. capsules, is usually well tolerated in doses as high as 3-6 grams, although side effects such as diarrhea, nausea, and, rarely, ataxia (unsteadiness) may occur in some people. (healthy.net)
  • L-arginine analogs as alternate substrates for nitric oxide synthase. (nih.gov)
  • The L-arginine analogs, N(delta)-methyl-L-arginine (deltaMA) and L-canavanine, were used to probe the role of the N delta nitrogen of L-arginine in the reaction catalyzed by nitric oxide synthase (NOS). (nih.gov)
  • Diminished levels of L-arginine and endothelial nitric oxide synthase (eNOS) uncoupling through deficiency of tetrahydrobiopterin (BH(4)) may contribute to endothelial dysfunction. (greenmedinfo.com)
  • Arginine is the only compound that Nitric Oxide Synthase can use to form Nitric Oxide. (puritan.com)
  • Lean white meat, such as turkey breast, contains the highest amount of arginine compared to other meats like chicken, pork, and beef - although they, too, have some arginine. (selfgrowth.com)
  • It has also been shown that significant levels of arginine in the body stimulate the natural secretion of growth hormones, assist in the natural production of creatine, reduce the recovery time for wounds, diminish the severity of migraine headaches, and may even help with specific cases of erectile dysfunction. (astronutrition.com)
  • Arginine deficiency can result in hair loss, constipation, a delay in the healing of wounds, and liver disease. (healthy.net)
  • These situations may lead to arginine deficiency, especially in those who by then have other illnesses or weakened immune systems. (selfgrowth.com)
  • The authors explained that pre-eclampsia is believed to be associated with L-arginine deficiency. (medicalnewstoday.com)
  • L-arginine is used for heart and blood vessel conditions including congestive heart failure (CHF), chest pain , high blood pressure , and coronary artery disease . (webmd.com)
  • You may also have been prescribed perindopril arginine if you have coronary artery disease. (news-medical.net)
  • In patients with coronary artery disease, perindopril arginine has been shown to reduce some of the risks, including heart attacks. (news-medical.net)
  • Hence, this amazing property of arginine has been looked into for managing erectile dysfunction, along with hypertension, coronary artery, and other cardiovascular diseases. (selfgrowth.com)
  • He conducted his own long-term study of arginine in 1998 which showed that large doses of arginine increased blood flow in coronary arteries by 150 percent and reduced the severity of angina by 70 percent. (stanford.edu)
  • L-arginine protects against ischemia/reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. (greenmedinfo.com)
  • We investigated the effect of L-arginine and BH(4) administration on ischemia-reperfusion (I/R)-induced endothelial dysfunction in patients with type 2 diabetes and coronary artery disease (CAD). (greenmedinfo.com)
  • Since arginine may help arteries relax and improve blood flow, it may also help with erectile dysfunction . (webmd.com)
  • L-arginine is also used for recurrent pain in the legs due to blocked arteries (intermittent claudication), decreased mental capacity in the elderly (senile dementia ), erectile dysfunction (ED), and male infertility . (webmd.com)
  • Erectile dysfunction (ED). Taking 5 grams of L-arginine by mouth daily seems to improve sexual function in men with ED. Taking lower doses might not be effective. (webmd.com)
  • People suffering from sexual problems, such as low libido or erectile dysfunction, may also benefit from the use of arginine cream. (wisegeek.com)
  • Arginine has been found to be beneficial in alleviating erectile dysfunction, the most common cause of failing sexual performance. (selfgrowth.com)
  • Based on clinical data, arginine has been found to significantly improve erectile function of varying severity. (selfgrowth.com)
  • Cialis is indicated for the treatment of erectile dysfunction l arginine viagra .eu/factbook/en/marketdata/electricity/supply/ electricitypricesineurope. (spiritofbaraka.com)
  • Deal can have diflucan, l arginine viagra together erectile or nippy reviews. (recoveryrestart.com)
  • Arginine, taken in combination with proanthocyanidins [4] or yohimbine [5] , has also been used as a treatment for erectile dysfunction . (wikidoc.org)
  • Perindopril arginine is a white, crystalline powder with a molecular weight 542.7. (rxlist.com)
  • Arginine methylation is a post-translational modification that controls the abundance of γc cytokine receptor on mature T cells by a post-transcriptional mechanism. (nature.com)
  • Fig. 1: The 'butterfly effect' of arginine methylation on the expression of and signaling via γc cytokine receptors. (nature.com)
  • Arginine methylation is a common posttranslational modification serving as an epigenetic regulator of gene transcription, pre-mRNA splicing, and PIWI-interacting RNA (piRNA) biogenesis. (pnas.org)
  • N-Acetylglutamate kinase (NAGK) catalyses the second step in the route of arginine biosynthesis. (rcsb.org)
  • Arginine is a naturally occurring amino acid. (ewg.org)
  • A person's body naturally produces L-arginine under normal circumstances. (medicalnewstoday.com)
  • Occasionally, a person's need for L-arginine may exceed the body's ability to produce or consume it naturally. (medicalnewstoday.com)
  • Because of the known fact that arginine is naturally converted into nitric oxide by the human body, the result of that chemical relaxing blood vessels was also known when the experiment began. (encyclopedia.com)
  • People with major depressive disorder (MDD) have lower levels of naturally occurring arginine in their body than their non-depressed controls, a study has found. (indianexpress.com)
  • L-Arginine is extremely important for many body functions and is usually only naturally present in low quantities. (carlsonlabs.com)
  • Furthermore, multiple arginine finger residues can all point towards the same point, thus focusing their effect. (wikipedia.org)
  • Thus, as Ras is an oncogene and is activated and deactivated by the hydrolysis of GTP, mutations in Ras's arginine finger residues can lead to cancer. (wikipedia.org)
  • or from excess lysine intake, which may compete with arginine. (healthy.net)
  • Recent research has suggested that L-arginine and L-lysine together have a similar effect, possibly at lower dosages. (healthy.net)
  • For example, if the arginine of the arginine finger is substituted by lysine, possibly due to a missense mutation, the αR364K mutant results. (wikipedia.org)
  • L-Lysine is an amino acid that opposes arginine. (apsense.com)
  • Arginine Alpha-Ketoglutarate is a derivative of arginine, engineered to increase arginine function of increasing nitric oxide more effectively. (australiansportsnutrition.com.au)
  • An amino acid compound called arginine alpha-ketoglutarate (A-AKG) and arginine-ketoisocaproate (A-KIC) can boost short term Nitric Oxide levels. (bodybuildingpro.com)
  • This leaflet answers some common questions about perindopril arginine. (news-medical.net)
  • It contains the active ingredient perindopril arginine. (news-medical.net)
  • Perindopril arginine helps lower your blood pressure. (news-medical.net)
  • Perindopril arginine helps to treat heart failure. (news-medical.net)
  • PRESTALIA is a combination of perindopril arginine and amlodipine besylate. (rxlist.com)
  • Perindopril arginine is the L-arginine salt of perindopril, the ethyl ester of a non-sulfhydryl angiotensin converting enzyme inhibitor. (rxlist.com)
  • Perindopril is the free-acid form of perindopril arginine. (rxlist.com)
  • PRESTALIA contains perindopril arginine, an angiotensin converting enzyme inhibitor, and amlodipine, a dihydropyridine calcium channel blocker, and is indicated for the treatment of hypertension, to lower blood pressure. (rxlist.com)
  • Generally, the role of the arginine finger in catalysis is to function in transition state stabilization to allow water to perform a nucleophilic attack to cleave off a number of phosphate groups. (wikipedia.org)
  • An Essential Role of the Arginine. (mendeley.com)
  • As a functional amino acid, l-arginine is generally more highly regarded compared to other functional amino acids such as tryptophan and tyrosine. (infobarrel.com)
  • In these studies, arginine increased the body's production of a blood vessel relaxant called nitric oxide. (stanford.edu)
  • L-arginine has been shown to stimulate the pituitary gland to produce and secrete human growth hormone in young males, at a dose of more than 3 grams daily. (healthy.net)
  • L-arginine also stimulates the release of growth hormone, insulin, and other substances in the body. (webmd.com)
  • Cherie Dawn Mills chmills at flash.net - - - - - - - - - - UNLEASHING THE UNCONSCIOUS: A Quest from Mystical Consciousness to Creative Adaptivity - by Cherie Dawn Mills - Introduction: For 1-1/2 years, through intermittent ingestion of the amino acid and growth hormone releaser, l-arginine, and through empathic prayer, I brought to consciousness the contents of my unconscious. (bio.net)
  • An oral dose of 5 to 9 grams of arginine increases resting growth hormone levels at least 100 percent, reported the January 2008 issue of "Current Opinion in Clinical Nutrition and Metabolic Care. (livestrong.com)
  • In addition, combining arginine with exercise does not enhance the growth hormone spike but actually attenuates it. (livestrong.com)
  • If you are taking arginine to increase your growth hormone levels, take it at least a few hours before or after exercise. (livestrong.com)
  • In addition, arginine triggers the release of HGH (human growth hormone) from the pituitary gland in the brain. (livestrong.com)
  • L-arginine boosts the production of growth hormone by the pituitary gland. (infobarrel.com)
  • Collectively, these results establish CASTOR1 as an arginine sensor for the mTORC1 pathway. (nih.gov)
  • This review focuses on the evolutionarily conserved chloroplast twin arginine transport (cpTat) pathway. (springer.com)
  • One of the highest sources of arginine in legumes comes from soybeans. (ehow.co.uk)
  • Soybeans and seaweed are other arginine-packed alternatives too. (selfgrowth.com)
  • Antinociceptive effect of L-arginine in diabetic mice. (biomedsearch.com)
  • The antinociceptive effect of L-arginine in streptozotocin-induced diabetic mice was examined. (biomedsearch.com)
  • However, neither beta-funaltrexamine, a selective mu-opioid receptor antagonist, nor nor-binaltorphimin ++, a selective kappa-opioid receptor antagonist, significantly affected the antinociceptive effect of L-arginine in diabetic and non-diabetic mice. (biomedsearch.com)
  • My personal experience several years ago using a combination of l-arginine, prayer, and imagery has led me to believe that this combination can aid integration of the personality, and can amplify creative common-sense in those people who are very sensitive to l-arginine. (bio.net)
  • The 3-D structure of homodimeric, arginine-insensitive, Escherichia coli NAGK, clarified substrate binding and catalysis but shed no light on arginine inhibition of NAGK. (rcsb.org)
  • We now shed light on arginine inhibition by determining the crystal structures, at 2.75 A and 2.95 A resolution, of arginine-complexed Thermotoga maritima and arginine-free Pseudomonas aeruginosa NAGKs, respectively. (rcsb.org)
  • Acetylglutamate counters arginine inhibition by promoting active centre closure. (rcsb.org)
  • The hexameric architecture justifies the observed sigmoidal arginine inhibition kinetics with a high Hill coefficient (N approximately 4), and appears essential for arginine inhibition and for NAGK-PII complex formation, since this complex may involve binding of NAGK and PII with their 3-fold axes aligned. (rcsb.org)
  • The NAGK structures allow identification of diagnostic sequence signatures for arginine inhibition. (rcsb.org)
  • The findings on NAGK shed light on the structure, function and arginine inhibition of this synthase, for which a hexameric model is constructed. (rcsb.org)
  • In diabetic patients, metformin and L-arginine had additive effects on blood pressure reduction, platelet aggregation inhibition, and blood viscosity reduction, and increased heart rate, plasma norepinephrine, and blood filterability ( 95 ). (livingnaturally.com)
  • Although s.c. administration of L-arginine produced a dose-dependent inhibition of the tail-flick response in both non-diabetic and diabetic mice, the antinociceptive response was greater in diabetic mice than in non-diabetic mice. (biomedsearch.com)
  • First isolated from animal horn (1895), arginine plays an important role in mammals in the synthesis of urea , the principal form in which these species excrete nitrogen . (britannica.com)
  • In molecular biology, an arginine finger is an amino acid residue of some enzymes. (wikipedia.org)
  • This calculation yields a more precise estimation of the bioavailability of arginine and thus the capacity to produce NO. (medscape.com)
  • In a previous study, the bioavailability of arginine was found to be decreased in patients with MDD. (medscape.com)
  • The results showed that people with depression had weaker arginine bioavailability than their non-depressed controls. (indianexpress.com)
  • Reduced arginine bioavailability is also known to be an independent risk factor of cardiovascular diseases, the researchers noted. (indianexpress.com)
  • However, we don't know yet what exactly causes reduced arginine bioavailability in people with depression," said lead author Toni Ali-Sisto, researcher at the University of Eastern Finland. (indianexpress.com)
  • However, in people who had recovered from depression the arginine bioavailability was found to be slightly higher than in people who remained depressed, the researchers said. (indianexpress.com)
  • Ganetzky pointed out that intravenous arginine is much more potent than oral arginine, adding "This study was an opportunity to more systematically analyze a therapy that is clinically used on an empiric basis in the course of acute clinical care. (eurekalert.org)
  • 139 ). Based on experience with intravenous arginine, it is possible that the use of high-dose oral arginine might alter potassium levels in the body, especially in people with severe liver disease ( 132 ). (livingnaturally.com)
  • Taurine and arginine are amino acids that may boost your fitness efforts. (livestrong.com)
  • There are actually safe, natural, and non-invasive ways to boost your arginine count. (selfgrowth.com)
  • L-arginine is a very important functional amino acid because of the profound effects it has on the cardiovascular system and on growth. (infobarrel.com)
  • L-arginine has been shown to support the cardiovascular system, through its conversion to nitric oxide and may also have positive benefits on recovery from athletic performance. (netrition.com)
  • In clinical trials , arginine has been used safely with minor side effects for up to three months. (webmd.com)
  • Two mitochondrial medicine experts from Children's Hospital of Philadelphia (CHOP) reported on eight years of clinical experience in providing intravenous (IV) arginine when new-onset neurologic problems concerning for acute stroke-like episode developed in nine pediatric mitochondrial disease patients. (eurekalert.org)
  • Recent clinical practice guidelines from the Mitochondrial Medicine Society recommended using IV arginine in patients having stroke-like episodes from MELAS, and considering its use at the time of stroke-like episodes in other mitochondrial diseases. (eurekalert.org)
  • Antacids, H2 blockers, proton pump inhibitors Antacids, H2 blockers, proton pump inhibitors: Due to the theoretical potential for L-arginine to increase gastrin, and thus stomach acid, L-arginine may reduce the effectiveness of these agents, although clinical evidence is lacking. (livingnaturally.com)
  • Abumrad NN, Barbul A (2004) The use of arginine in clinical practice. (springer.com)
  • Sometimes, there is an abnormally heightened activity of the enzyme arginase, responsible for catalyzing arginine into urea that is expelled in urine. (selfgrowth.com)
  • Adults, however, are able to synthesize arginine in the urea cycle . (wikidoc.org)
  • As a result, researchers have investigated the effectiveness of L-arginine in the treatment of severe wounds and tissue waste in serious illnesses. (medicalnewstoday.com)
  • However, there is some early evidence that adding 40 mg of Pycnogenol three times daily might improve the effectiveness of low-dose L-arginine for ED. (webmd.com)
  • Studies are being conducted on the effectiveness of arginine to help with other conditions like diabetes, and immune system regulation. (reference.com)
  • In the body, the amino acid arginine changes into nitric oxide (NO). Nitric oxide is a powerful neurotransmitter that helps blood vessels relax and also improves circulation. (webmd.com)
  • Some evidence shows that arginine may help improve blood flow in the arteries of the heart. (webmd.com)
  • There are other potential health benefits with arginine, such as possible reduction of blood pressure in some people and improved walking distance in patients with intermittent leg cramping and weakness known as intermittent claudication. (webmd.com)
  • Arginine may interact with certain medications that lower blood pressure. (webmd.com)
  • Some people use L-arginine for preventing the common cold , improving kidney function after a kidney transplant , high blood pressure during pregnancy (pre- eclampsia ), improving athletic performance, boosting the immune system, and preventing inflammation of the digestive tract in premature infants. (webmd.com)
  • Some people apply L-arginine to the skin to speed wound healing and for increasing blood flow to cold hands and feet, especially in people with diabetes . (webmd.com)
  • There is early evidence that taking L-arginine by mouth can reduce blood pressure in healthy people, people with high blood pressure, and people with slightly high blood pressure with or without diabetes. (webmd.com)
  • Research suggests that taking L-arginine by mouth or intravenously (by IV) for up to 8 weeks increases blood flow in people with peripheral arterial disease. (webmd.com)
  • The group that took the arginine alone showed an improvement in their blood-vessel dilation by four times, as did the group doing exercises alone. (encyclopedia.com)
  • According to an article by Liz Brown written in Better Nutrition in June 2000, also discussing the Leipzig study, "Numerous other studies have shown that arginine has a vadodilatory effect on people with high cholesterol levels, those with high blood pressure and others with compromised circulation associated with heart disease. (encyclopedia.com)
  • Other research in the use of arginine has indicated that arginine is crucial to the wound-healing process, particularly in the elderly for whom blood circulation is poor. (encyclopedia.com)
  • In 1988, Salvador Moncada clearly demonstrated that blood vessels make NO from L-arginine. (selfgrowth.com)
  • Arginine is one of the compounds responsible for helping blood vessels contract and expand, helping to control blood flow. (reference.com)
  • L-arginine Plus is used to support healthy blood pressure, healthy cholesterol, healthy circulation, healthy energy levels, and to support muscle development. (chiroeco.com)
  • L-arginine may cause your blood pressure to drop, so if you have low blood pressure or take medications to control your blood pressure, you should avoid L-arginine or consult a doctor before trying it. (healthline.com)
  • Arginine cream could stimulate more blood flow to the woman's sexual organs, and therefore help her better enjoy intercourse. (wisegeek.com)
  • In people, arginine changes into nitrous oxide, which is a compound that causes blood vessels and tissues to relax and dilate. (wisegeek.com)
  • When applied to the skin, arginine cream may help improve circulation and increase blood flow in the extremities, like the hands. (wisegeek.com)
  • In this regard, l-arginine is important because it plays a necessary role in maintaining the structural integrity of various tissues, particularly, the blood vessels and the skin. (infobarrel.com)
  • L-arginine has a significant effect on the structure of the blood vessels. (infobarrel.com)
  • L-Arginine can open up these cholesterol-clogged arteries and improve blood flow. (infobarrel.com)
  • L-arginine can also prevent or slow down the deposition of cholesterol in the vascular walls so that impairment of blood flow would not occur in the first place. (infobarrel.com)
  • One of its forms, L-arginine in particular, was discovered to enhance blood circulation, a characteristic essential to better sexual performance among men and women. (selfgrowth.com)
  • L-arginine does its magic when the body converts it into nitric oxide, a substance that relaxes blood vessels and promotes healthy blood flow to the different tissues and organs, including the genitals. (selfgrowth.com)
  • If you are asthmatic, have allergies, low blood pressure, or bowel problems, arginine may not be for you. (selfgrowth.com)
  • Two-hundred and sixty-three plasma amino-acidograms with a large series of additional biochemical and blood variables were obtained consecutively in 9 trauma patients who developed sepsis, undergoing total parenteral nutrition with dextrose, fat and a mixed AA solution containing 10.4% arginine. (springer.com)
  • L-arginine is an amino acid, it helps maintain good blood flow during pregnancy. (medicalnewstoday.com)
  • Their L-arginine levels plus blood pressure were measured every three to four weeks at the hospital. (medicalnewstoday.com)
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  • L-Arginine is necessary for the endothelium (the inner lining of blood vessels) to produce nitric oxide. (verichipcorp.com)
  • Not only leading to increased blood flow to muscles, arginine AKG effect creates an increase in muscle volume, known as a "pump" creating a desirable feeling of strength and fullness during resistance training. (australiansportsnutrition.com.au)
  • Aim of the study is to evaluate the effect of arginine and N-acetylcysteine administration on arterial blood pressure and different metabolic parameters in patients with type 2 diabetes mellitus and hypertension. (clinicaltrials.gov)
  • Effects of Arginine and N-Acetylcysteine Administration on Nitric Oxide Production and Arterial Blood Pressure in Hypertensive Diabetic Patients. (clinicaltrials.gov)
  • Your body converts l-arginine into nitric oxide which helps relax blood vessels. (babyhopes.com)
  • For women, L-arginine can help improve cervical mucus production and improve blood circulation to the uterus supporting a healthy menstrual flow and improve the uterine lining. (babyhopes.com)
  • Note: Do not use if you have high blood pressure or take HBP medications as L-arginine is a vasodilator and can interact with your medications. (babyhopes.com)
  • HOW TO USE: Arginine cream can be used "in the moment" and applied directly sensitive areas for increased blood flow and sensitivity. (babyhopes.com)
  • L-Arginine can improve blood flow and result in an improved and more powerful experience. (babyhopes.com)
  • These subjects will undergo a treatment with arginine (1200 mg once a day) plus N-acetylcysteine (600 mg twice a day) or placebo for six months. (clinicaltrials.gov)
  • Most nuts have approximately 2-4 grams of arginine per 100 gram serving, according to Dietary Fiber Food. (ehow.co.uk)
  • Aminophylline Aminophylline: Theoretically, aminophylline may decrease glucagon response to arginine. (livingnaturally.com)
  • Both phases of the normal biphasic insulin response to arginine were decreased during the initial arginine infusion. (diabetesjournals.org)
  • At other times, the underlying issue may be a slowing down in the synthesis of arginine itself. (selfgrowth.com)
  • New information released in 2002 showed that treatment with arginine improved immune function in HIV patients and proved safe for these patients when used on a short-term patients. (encyclopedia.com)
  • L-arginine is a nonessential amino acid, because under normal circumstances it can be synthesized from other precursors. (livestrong.com)
  • Arginine is a nonessential amino acid , meaning it can be manufactured by the human body, and does not need to be obtained directly through the diet. (wikidoc.org)
  • Promise in the future use of arginine in treating heart patients with this condition was indicated as researchers continued to perform further tests. (encyclopedia.com)
  • Arginine cream can help improve circulation in the feet for diabetic patients. (wisegeek.com)
  • Arginine is already used to acutely treat these complex strokes in adult patients who have a well-known mitochondrial disease syndrome called MELAS (mitochondrial encephalopathy with lactic acidosis and stroke-like episodes). (eurekalert.org)
  • Magnetic resonance imaging (MRI) performed in some patients showed that brain changes caused by the stroke returned to normal after patients received IV arginine. (eurekalert.org)
  • But in his long-term study of arginine, which involved 133 patients, Cooke found there is no benefit and may be some possible harm in the long-term use of arginine in patients with PAD. (stanford.edu)
  • The history of arginine as a treatment for heart disease began in the early 1990s, when Cooke's lab and other scientists found a benefit for heart patients in small, short-term studies. (stanford.edu)
  • Measures of nitric oxide in the patients who took arginine were found to be not improved or reduced compared with the placebo group. (stanford.edu)
  • The patients received a 15 min intra-brachial infusion of L-arginine (20 mg/min) and BH(4) (500 microg/min) or 0.9% saline starting at 15 min of ischemia on two separate study occasions. (greenmedinfo.com)
  • Patients with acute pancreatitis were studied by arginine infusion at 48-72 h, 7-10 days, and 18-21 days after onset of their illness. (diabetesjournals.org)
  • L-arginine has a positive effect on the immune system, mainly by stimulating thymus activity, and also helps the body heal from wounds. (healthy.net)
  • Arginine (ARG) is an amino acid (AA) with unique properties and with a key-role in the metabolic, immune and reparative response to trauma and sepsis. (springer.com)
  • AllMax Arginine HCl is an ultra pure form of Arginine that is formulated to improve immune function and increases muscle mass. (netrition.com)
  • Arginine plays an important role in cell division, the healing of wounds, removing ammonia from the body, immune function, and the release of hormones. (wikidoc.org)
  • Arginine - an amino acid which the body uses to produce nitric oxide - is a nervous system and immune defence mediator, which also plays a role in vascular regulation. (indianexpress.com)
  • Because of this, L-Arginine also supports a healthy immune system and athletic performance. (carlsonlabs.com)
  • Nuts are convenient snack food options, making it easy to consume enough arginine. (ehow.co.uk)
  • Mix 1/4 teaspoon of Arginine AKG in water and consume 20 minutes before exercise. (australiansportsnutrition.com.au)
  • Besides, arginine is vital for bone growth and excretion of waste substances from the body. (verichipcorp.com)