Arenaviruses, New World: One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. It includes JUNIN VIRUS; PICHINDE VIRUS; Amapari virus, and Machupo virus among others. They are the cause of human hemorrhagic fevers mostly in Central and South America.Arenaviruses, Old World: One of two groups of viruses in the ARENAVIRUS genus and considered part of the Old World complex. It includes LASSA VIRUS and LYMPHOCYTIC CHORIOMENINGITIS VIRUS, although the latter has worldwide distribution now.Arenavirus: The only genus in the family ARENAVIRIDAE. It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution.Arenaviridae Infections: Virus diseases caused by the ARENAVIRIDAE.Lassa virus: A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.Arenaviridae: A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). Infection in rodents is persistent and silent. Vertical transmission is through milk-, saliva-, or urine-borne routes. Horizontal transmission to humans, monkeys, and other animals is important.Hemorrhagic Fevers, Viral: A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.Platyrrhini: An infraorder of New World monkeys, comprised of the families AOTIDAE; ATELIDAE; CEBIDAE; and PITHECIIDAE. They are found exclusively in the Americas.Junin virus: A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. The disease is characterized by congestion, edema, generalized lymphadenopathy and hemorrhagic necrosis and is sometimes fatal.Hemorrhagic Fever, American: Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).Cebidae: A family of New World monkeys in the infraorder PLATYRRHINI, consisting of nine subfamilies: ALOUATTINAE; AOTINAE; Atelinae; Callicebinae; CALLIMICONINAE; CALLITRICHINAE; CEBINAE; Pithecinae; and SAIMIRINAE. They inhabit the forests of South and Central America, comprising the largest family of South American monkeys.Pichinde virus: A species of ARENAVIRUS, one of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing a fatal infection in the cricetine rodent Oryzomys albigularis. Asymptomatic laboratory infection in humans has been reported.Virus Physiological Processes: Biological activities of viruses and their interactions with the cells they infect.Lymphocytic choriomeningitis virus: The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.Cercopithecidae: The family of Old World monkeys and baboons consisting of two subfamilies: CERCOPITHECINAE and COLOBINAE. They are found in Africa and part of Asia.Dystroglycans: Dystrophin-associated proteins that play role in the formation of a transmembrane link between laminin-2 and DYSTROPHIN. Both the alpha and the beta subtypes of dystroglycan originate via POST-TRANSLATIONAL PROTEIN PROCESSING of a single precursor protein.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Transferrins: A group of iron-binding proteins that tightly bind two ferrate ions along with two carbonate ions. They are found in the bodily fluids of vertebrates where they act as transport and storage molecules for iron.Callithrix: A genus of the subfamily CALLITRICHINAE occurring in forests of Brazil and Bolivia and containing seventeen species.Filoviridae: A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.Lassa Fever: An acute febrile human disease caused by the LASSA VIRUS.Americas: The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.Saguinus: A genus in the subfamily CALLITRICHINAE consisting of 12 species and found in Panama as well as South America. Species seen most frequently in the literature are S. oedipus (cotton-top marmoset), S. nigricollis, and S. fusicollis.Saimiri: A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.Virus Internalization: The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.Aotidae: A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).Boidae: A family of snakes comprising the boas, anacondas, and pythons. They occupy a variety of habitats through the tropics and subtropics and are arboreal, aquatic or fossorial (burrowing). Some are oviparous, others ovoviviparous. Contrary to popular opinion, they do not crush the bones of their victims: their coils exert enough pressure to stop a prey's breathing, thus suffocating it. There are five subfamilies: Boinae, Bolyerinae, Erycinae, Pythoninae, and Tropidophiinae. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p315-320)Receptors, Virus: Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.Cebus: A genus of the family CEBIDAE, subfamily CEBINAE, consisting of four species which are divided into two groups, the tufted and untufted. C. apella has tufts of hair over the eyes and sides of the head. The remaining species are without tufts - C. capucinus, C. nigrivultatus, and C. albifrons. Cebus inhabits the forests of Central and South America.Vero Cells: A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.Cercopithecus aethiops: A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.Snakes: Limbless REPTILES of the suborder Serpentes.Rodent Diseases: Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Rodentia: A mammalian order which consists of 29 families and many genera.Nucleoproteins: Proteins conjugated with nucleic acids.PrimatesNorth AmericaReceptors, Transferrin: Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.Viral Proteins: Proteins found in any species of virus.Alouatta: A genus of the subfamily ALOUATTINAE, family ATELIDAE, inhabiting the forests of Central and South America. Howlers travel in groups and define their territories by howling accompanied by vigorously shaking and breaking branches.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Virus Attachment: The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.Peromyscus: A genus of the subfamily SIGMODONTINAE consisting of 49 species. Two of these are widely used in medical research. They are P. leucopus, or the white-footed mouse, and P. maniculatus, or the deer mouse.Nucleocapsid Proteins: Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).Aotus trivirgatus: A species in the family AOTIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys.RNA, Viral: Ribonucleic acid that makes up the genetic material of viruses.Inclusion Bodies, Viral: An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Atelinae: A subfamily in the family ATELIDAE, comprising three genera: woolly monkeys (Lagothrix), spider monkeys (Ateles), and woolly spider monkeys (Brachyteles).Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.History, Ancient: The period of history before 500 of the common era.Electron Microscope Tomography: A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.Host-Pathogen Interactions: The interactions between a host and a pathogen, usually resulting in disease.Proprotein Convertases: Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.South AmericaStrepsirhini: A suborder of PRIMATES consisting of the following five families: CHEIROGALEIDAE; Daubentoniidae; Indriidae; LEMURIDAE; and LORISIDAE.Cricetinae: A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.World Health Organization: A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.Viral Vaccines: Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.Camelids, New World: Ruminant mammals of South America. They are related to camels.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Virus Release: Release of a virus from the host cell following VIRUS ASSEMBLY and maturation. Egress can occur by host cell lysis, EXOCYTOSIS, or budding through the plasma membrane.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Antiviral Agents: Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.World Health: The concept pertaining to the health status of inhabitants of the world.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Genome, Viral: The complete genetic complement contained in a DNA or RNA molecule in a virus.RNA Viruses: Viruses whose genetic material is RNA.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Callitrichinae: A subfamily in the family CEBIDAE that consists of four genera: CALLITHRIX (marmosets), CALLIMICO (Goeldi's monkey), LEONTOPITHECUS (lion tamarins), and SAGUINUS (long-tusked tamarins). The members of this family inhabit the tropical forests of South and Central America.Pitheciidae: A family of New World monkeys in the infraorder PLATYRRHINI consisting of two subfamilies: Callicebinae and Pitheciinae.History, 15th Century: Time period from 1401 through 1500 of the common era.Viral Envelope Proteins: Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.Biological Evolution: The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.Lymphocytic Choriomeningitis: A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)Indians, South American: Individual members of South American ethnic groups with historic ancestral origins in Asia.Monkey Diseases: Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).Leishmaniasis, Mucocutaneous: A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.Hominidae: Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).Leishmania: A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi.Virus Replication: The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.Siberia: A region, north-central Asia, largely in Russia. It extends from the Ural Mountains to the Pacific Ocean and from the Arctic Ocean to central Kazakhstan and the borders of China and Mongolia.Hantavirus: A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. Infection is found primarily in rodents and humans. Transmission does not appear to involve arthropods. HANTAAN VIRUS is the type species.Virus Cultivation: Process of growing viruses in live animals, plants, or cultured cells.EcuadorGeography: The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)History, 16th Century: Time period from 1501 through 1600 of the common era.Asia: The largest of the continents. It was known to the Romans more specifically as what we know today as Asia Minor. The name comes from at least two possible sources: from the Assyrian asu (to rise) or from the Sanskrit usa (dawn), both with reference to its being the land of the rising sun, i.e., eastern as opposed to Europe, to the west. (From Webster's New Geographical Dictionary, 1988, p82 & Room, Brewer's Dictionary of Names, 1992, p34)Central AmericaVirion: The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.Cross Reactions: Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.Dryopteridaceae: The wood fern plant family of the order Polypodiales, class Filicopsida, division Pteridophyta.Haplorhini: A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).Antibodies, Viral: Immunoglobulins produced in response to VIRAL ANTIGENS.DNA, Mitochondrial: Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.Cryoelectron Microscopy: Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.Genetic Variation: Genotypic differences observed among individuals in a population.Antigens, Viral: Substances elaborated by viruses that have antigenic activity.Iridaceae: A monocot plant family of the Liliopsida class. It is classified by some in the Liliales order and some in the Asparagales order.Leishmaniasis, Cutaneous: An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.Simian foamy virus: A species of SPUMAVIRUS causing non-pathogenic infections in chimpanzees and humans.Lemur: A genus of the family Lemuridae consisting of five species: L. catta (ring-tailed lemur), L. fulvus, L. macaco (acoumba or black lemur), L. mongoz (mongoose lemur), and L. variegatus (white lemur). Most members of this genus occur in forested areas on Madagascar and the Comoro Islands.Archaeology: The scientific study of past societies through artifacts, fossils, etc.Phylogeography: A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)World War II: Global conflict involving countries of Europe, Africa, Asia, and North America that occurred between 1939 and 1945.Indians, Central American: Individual members of Central American ethnic groups with ancient historic ancestral origins in Asia. Mexican Indians are not included.Antigens, CD: Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.Pongo pygmaeus: A species of orangutan, family HOMINIDAE, found in the forests on the island of Borneo.

Experimental infection of the cane mouse Zygodontomys brevicauda (family Muridae) with guanarito virus (Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. (1/127)

Chronic infections in specific rodents appear to be crucial to the long-term persistence of arenaviruses in nature. The cane mouse, Zygodontomys brevicauda, is a natural host of Guanarito virus (family Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. The purpose of this study was to elucidate the natural history of Guanarito virus infection in Z. brevicauda. Thirty-nine laboratory-reared cane mice each were inoculated subcutaneously with 3.0 log10 plaque-forming units of the Guanarito virus prototype strain INH-95551. No lethality was associated with infection in any animal, regardless of age at inoculation. The 13 newborn, 14 weanling, and 8 of the 12 adult animals developed chronic viremic infections characterized by persistent shedding of infectious virus in oropharyngeal secretions and urine. These findings indicate that Guanarito virus infection in Z. brevicauda can be chronic and thus support the concept that this rodent species is the natural reservoir of Guanarito virus.  (+info)

Guanarito virus (Arenaviridae) isolates from endemic and outlying localities in Venezuela: sequence comparisons among and within strains isolated from Venezuelan hemorrhagic fever patients and rodents. (2/127)

Despite intensive surveillance, Venezuelan hemorrhagic fever (VHF), caused by Guanarito (GTO) virus, has been detected in only a small region of western Venezuela. To determine whether VHF is associated with a particular regional GTO virus strain(s), 29 isolates from rodents and humans throughout the surrounding regions were analyzed by partial sequencing of the nucleocapsid protein gene. Phylogenetic trees delineated nine distinct GTO genotypes that differ by 4-17% in nucleotides and up to 9% in amino acid sequences; most appeared to be restricted to discrete geographic regions, although a few genotypes were isolated in several locations. Each genotype included at least one strain recovered from a rodent, but only two genotypes were isolated from VHF cases. The presence outside of the endemic/epidemic region of two genotypes isolated also from VHF cases suggests that human pathogenic viruses occur outside of the endemic zone, but do not frequently infect people and/or cause apparent disease there. VHF does not appear to be associated with a GTO virus genotype that is restricted to a certain rodent species. When quasispecies diversity was examined, rodent isolates had higher sequence variation than human isolates. One rodent isolate included a mixture of two phylogenetically distinct genotypes, suggesting a dual infection.  (+info)

Homologous and heterologous glycoproteins induce protection against Junin virus challenge in guinea pigs. (3/127)

Tacaribe virus (TACV) is an arenavirus that is genetically and antigenically closely related to Junin virus (JUNV), the aetiological agent of Argentine haemorrhagic fever (AHF). It is well established that TACV protects experimental animals fully against an otherwise lethal challenge with JUNV. To gain information on the nature of the antigens involved in cross-protection, recombinant vaccinia viruses were constructed that express the glycoprotein precursor (VV-GTac) or the nucleocapsid protein (VV-N) of TACV. TACV proteins expressed by vaccinia virus were indistinguishable from authentic virus proteins by gel electrophoresis. Guinea pigs inoculated with VV-GTac or VV-N elicited antibodies that immunoprecipitated authentic TACV proteins. Antibodies generated by VV-GTac neutralized TACV infectivity. Levels of antibodies after priming and boosting with recombinant vaccinia virus were comparable to those elicited in TACV infection. To evaluate the ability of recombinant vaccinia virus to protect against experimental AHF, guinea pigs were challenged with lethal doses of JUNV. Fifty per cent of the animals immunized with VV-GTac survived, whereas all animals inoculated with VV-N or vaccinia virus died. Having established that the heterologous glycoprotein protects against JUNV challenge, a recombinant vaccinia virus was constructed that expresses JUNV glycoprotein precursor (VV-GJun). The size and reactivity to monoclonal antibodies of the vaccinia virus-expressed and authentic JUNV glycoproteins were indistinguishable. Seventy-two per cent of the animals inoculated with two doses of VV-GJun survived lethal JUNV challenge. Protection with either VV-GJun or VV-GTac occurred in the presence of low or undetectable levels of neutralizing antibodies to JUNV.  (+info)

The Whitewater Arroyo virus: natural evidence for genetic recombination among Tacaribe serocomplex viruses (family Arenaviridae). (4/127)

The Tacaribe serocomplex (family Arenaviridae) comprises three phylogenetic lineages, designated A, B, and C. The sequence of a 3278-nt fragment of the small genomic segment of the Whitewater Arroyo (WWA) virus was determined to extend our knowledge on the phylogenetic relationship of this newly discovered North American Tacaribe complex virus to other arenaviruses. Independent analyses of full-length nucleoprotein (N) and glycoprotein precursor (GPC) amino acid sequences indicated that the WWA virus N and GPC genes are descended from a lineage A virus and lineage B virus, respectively. The different phylogenetic histories of the N and GPC genes indicate that the WWA virus genome is a product of recombination between two Tacaribe complex viruses.  (+info)

Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral hemorrhagic fever. (5/127)

Adult Syrian golden hamsters inoculated intraperitoneally with Pirital virus, a recently discovered member of the Tacaribe complex of New World arenaviruses, developed a progressively severe, fatal illness with many of the pathologic features observed in fatal human cases of Lassa fever and other arenaviral hemorrhagic fevers. Most of the animals became moribund by Day 5 and were dead by Day 7 after inoculation. The most consistent histopathologic changes included interstitial pneumonitis, splenic lymphoid depletion and necrosis, and multifocal hepatic necrosis without significant inflammatory cell infiltration. The liver changes ranged from single cell death by apoptosis to coagulative necrosis of clusters of hepatocytes. Immunohistochemical studies of the liver demonstrated the presence and accumulation ot Pirital virus antigen within hepatocytes as well as Kupffer cells. An in situ terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay showed progressively increasing apoptotic activity in the liver of infected hamsters. A human hepatoblastoma cell line (Hep G2/C3A) inoculated with Pirital virus also developed progressive cell destruction and accumulation of viral antigen, as demonstrated by immunofluorescence. Results of this pilot study suggest that the Pirital virus-hamster model is a very promising new small animal model for studying the pathogenesis of arenavirus infections, particularly, the mechanism of direct virus-induced hepatic injury. It may also be useful for testingantiviral agents for treatment of arenaviral hemorrhagic fevers.  (+info)

Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors. (6/127)

Here we provide the first report of protection against a vaginal challenge with a highly virulent simian immunodeficiency virus (SIV) by using a vaccine vector. New poliovirus vectors based on Sabin 1 and 2 vaccine strain viruses were constructed, and these vectors were used to generate a series of new viruses containing SIV gag, pol, env, nef, and tat in overlapping fragments. Two cocktails of 20 transgenic polioviruses (SabRV1-SIV and SabRV2-SIV) were inoculated into seven cynomolgus macaques. All monkeys produced substantial anti-SIV serum and mucosal antibody responses. SIV-specific cytotoxic T-lymphocyte responses were detected in three of seven monkeys after vaccination. All 7 vaccinated macaques, as well as 12 control macaques, were challenged vaginally with pathogenic SIVmac251. Strikingly, four of the seven vaccinated animals exhibited substantial protection against the vaginal SIV challenge. All 12 control monkeys became SIV positive. In two of the seven SabRV-SIV-vaccinated monkeys we found no virological evidence of infection following challenge, indicating that these two monkeys were completely protected. Two additional SabRV-SIV-vaccinated monkeys exhibited a pronounced reduction in postacute viremia to <10(3) copies/ml, suggesting that the vaccine elicited an effective cellular immune response. Three of six control animals developed clinical AIDS by 48 weeks postchallenge. In contrast, all seven vaccinated monkeys remained healthy as judged by all clinical parameters. These results demonstrate the efficacy of SabRV as a potential human vaccine vector, and they show that the use of a vaccine vector cocktail expressing an array of defined antigenic sequences can be an effective vaccination strategy in an outbred population.  (+info)

Transcription and RNA replication of tacaribe virus genome and antigenome analogs require N and L proteins: Z protein is an inhibitor of these processes. (7/127)

Tacaribe virus (TV), the prototype of the New World group of arenaviruses, comprises a single phylogenetic lineage together with four South American pathogenic producers of hemorrhagic disease. The TV genome consists of two single-stranded RNA segments called S and L. A reconstituted transcription-replication system based on plasmid-supplied TV-like RNAs and TV proteins was established. Plasmid expression was driven by T7 RNA polymerase supplied by a recombinant vaccinia virus. Plasmids were constructed to produce TV S segment analogs containing the negative-sense copy of chloramphenicol acetyltransferase (CAT) flanked at the 5' and 3' termini by sequences corresponding to those of the 5' and 3' noncoding regions of the S genome (minigenome) or the S antigenome (miniantigenome). In cells expressing N and L proteins, input minigenome or miniantigenome produced, respectively, encapsidated miniantigenome or minigenome which in turn produced progeny minigenome or progeny miniantigenome. Both minigenome and miniantigenome in the presence of N and L mediated transcription, which was analyzed as CAT expression. Coexpression of the small RING finger Z (p11) protein was highly inhibitory to both transcription and replication mediated by the minigenome or the miniantigenome. The effect depended on synthesis of Z protein rather than on plasmid or the RNA and was not ascribed to decreased amounts of plasmid-supplied template or proteins (N or L). N and L proteins were sufficient to support full-cycle RNA replication of a plasmid-supplied S genome analog in which CAT replaced the N gene. Replication of this RNA was also inhibited by Z expression.  (+info)

New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor. (8/127)

Alpha-dystroglycan (alpha-DG) has been identified as a major receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa virus, two Old World arenaviruses. The situation with New World arenaviruses is less clear: previous studies demonstrated that Oliveros virus also exhibited high-affinity binding to alpha-DG but that Guanarito virus did not. To extend these initial studies, several additional Old and New World arenaviruses were screened for entry into mouse embryonic stem cells possessing or lacking alpha-DG. In addition, representative viruses were further analyzed for direct binding to alpha-DG by means of a virus overlay protein blot assay technique. These studies indicate that Old World arenaviruses use alpha-DG as a major receptor, whereas, of the New World arenaviruses, only clade C viruses (i.e., Oliveros and Latino viruses) use alpha-DG as a major receptor. New World clade A and B arenaviruses, which include the highly pathogenic Machupo, Guanarito, Junin, and Sabia viruses, appear to use a different receptor or coreceptor for binding. Previous studies with LCMV have suggested the need for a small aliphatic amino acid at LCMV GP1 glycoprotein amino acid position 260 to allow high-affinity binding to alpha-DG. As reported herein, this requirement appears to be broadly applicable to the arenaviruses as determined by more extensive analysis of alpha-DG receptor usage and GP1 sequences of Old and New World arenaviruses. In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position.  (+info)

Looking for Guanarito virus? Find out information about Guanarito virus. parasite with a noncellular structure composed mainly of nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living... Explanation of Guanarito virus
Neighbor-joining phylogenetic tree of Machupo virus derived from the glycoprotein precursor gene sequence. The neighbor-joining and maximum likelihood analyses
The superfamily Certhioidea is distributed on four continents and while comprising relatively few species, includes forms as diverse as creepers, nuthatches, gnatcatchers, and wrens. Previous attempts to infer the phylogeny of this lineage have focused on its higher-level relationships, consequently undersampling the New World wrens. This study reports the first nearly genus-level sampling of certhioids, based on concatenated and species tree analyses of 8520 bases of DNA sequence data from six gene regions. These analyses, while failing to completely resolve basal certhioid relationships, corroborate the monophyly of a diverse New World clade of gnatcatchers, gnatwrens, and wrens, and significantly improve our understanding of wren relationships. The inferred relationships among certhioids and wrens support an Old World origin for these lineages, with dispersal of the New World clade in the mid-Miocene, suggesting expansion and early diversification of the lineage through North America. This ...
Nucleic Acid: Plasmid for expression of the LCMV S-segment with heterologous arenavirus GP - Machupo (Expression plasmid, Diagnostic reagent, Derived product, Nucleic Acid, Cloned nucleic acid)
... ,Template and primers for preparation of internal control spots,biological,biology supply,biology supplies,biology product
Pentair products shall be installed and used only as indicated in Pentairs product instruction sheets and training materials. Instruction sheets are available at www.erico.pentair.com and from your Pentair customer service representative. Improper installation, misuse, misapplication or other failure to completely follow Pentairs instructions and warnings may cause product malfunction, property damage, serious bodily injury and death and/or void your warranty. ...
Several viruses in the Arenaviridae family infect humans and cause severe hemorrhagic fevers which lead to high case fatality rates. Due to their pathogenicity and geographic tropisms, these viruses remain very understudied. As a result, an effective vaccine or therapy is urgently needed. Here, we describe efforts to produce cross-reactive monoclonal antibodies that bind to both New and Old World arenaviruses. All of our MAbs seem to be nonneutralizing and nonprotective and target subunit 2 of the glycoprotein. Due to the lack of reagents such as recombinant glycoproteins and antibodies for rapid detection assays, our MAbs could be beneficial as analytic and diagnostic tools.
Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. The majority of these viruses are rodent-borne and the arenavirus family can be divided into two groups: the Lassa-Lymphocytic choriomeningitis serocomplex and the Tacaribe serocomplex. Arenavirus-induced disease may include characteristic symptoms ranging from fever, malaise, body aches, petechiae, dehydration, hemorrhage, organ failure, shock, and in severe cases death. Currently, there are few prophylactic and therapeutic treatments available for arenavirus-induced symptoms. Supportive care and ribavirin remain the predominant strategies for treating most of the arenavirus-induced diseases. Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. Because of the potential for person-to-person spread, the ability to cause lethal or debilitating disease in humans,
PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
FBI will investigate the Texas biolab where a deadly virus went missing, according to the Centers for Disease Control and Prevention.
I wrote a couple of months ago about the burgeoning Arroyo Food Co-Op. It would be a locally owned and operated operation combining the best of the local-foods movement, the slow-food movement, the fun and tasty farmers markets that are so popular in so many of our cities, Jones Coffee and Europane, Trader Joes and Whole Foods. Then I sort of forgot about it. But running on an Upper Arroyo trail the other morning, Pasadenan Mia Dunn dashed downhill past me, made some remarks about what a good-looking dog I was out with - complimenting Charlie is always a good way to get to me - and said that the Co-Op is going great guns. Its still early days for the homegrown community market that would serve the Pasadena area. Theres no bricks and mortar up yet in which to shop for heirloom nectarines. But a board of directors has been elected, and Patrick Reagan was elected chair of that. The board is having a meeting Thursday night - tomorrow - at 7 p.m. at 33 S. Catalina Ave., No. 104, Pasadena, and ...
Advice about rent vs buy in Arroyo Seco on Trulia Voices. Ask a question about real estate , rent vs buy in Arroyo Seco, and get answers from local experts.
Scandal ridden former councilmember Ed Arnold stepped down to allow the Arroyo Grande City Council to avoid distraction related to his personal life, and at his replacements first council meeting, questions about her lifestyle started a confrontation between her supporters and her critics. Public comment about recently appointed Arroyo Grande Councilwoman Karen Rays, activities with the SLO Hash House Harriers brought a moment of stunned silence to tonights City Council meeting.
The Center for One Health Research Department of Environment & Occupational Health Sciences School of Public Health University of Washington Box 357234 Seattle, WA, USA ...
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USGS National Water Census Water Budget Data Resources for the Sand Arroyo - HUC 11040004 (Turn off compatibility view settings in IE if having problems viewing this site) ...
President Rodrigo Duterte said he was considering naming former president and Pampanga Rep. Gloria Arroyo to a body that will propose changes to the 1987 Constitution.
That said, Arroyo was a sensational apprentice at Suffolk Downs and went on to great success on the NYRA circuit before his issues began to catch up with him. He was from Somerville, Mass., a suburb of Boston. I recall sitting in the simulcast area at Suffolk one weekend and getting into a conversation with a man who told me he knew Arroyo quite well -- he was the assistant principal (or some similar title) at Somerville High School when Arroyo was a student there. "He spent a lot of time in my office," he told me. Anyone familiar with the traditional duties of an assistant principal knows what that means ...
Epitope curation should be conducted in the following priority order: A) NIAID Category A, B, and C priority pathogens and toxins: The complete list of NIAID Category A, B, and C priority pathogens and toxins can be found at the following URL: http://www2.niaid.nih.gov/biodefense/bandc_priority.htm. NIAID - Category A Bacillus anthracis (anthrax) Clostridium botulinum Yersinia pestis Variola major (smallpox) and other pox viruses Francisella tularensis (tularemia) Viral hemorrhagic fevers Arenaviruses LCM, Junin virus, Machupo virus, Guanarito virus Lassa Fever Bunyaviruses Hantaviruses Rift Valley Fever Flaviruses Dengue Filoviruses Ebola Marburg NIAID - Category B Burkholderia pseudomallei Coxiella burnetii (Q fever) Brucella species (brucellosis) Burkholderia mallei (glanders) Ricin toxin (from Ricinus communis) Epsilon toxin of Clostridium perfringens Staphylococcus enterotoxin B Typhus fever (Rickettsia prowazekii) Food and Waterborne Pathogens Bacteria Diarrheagenic E.coli Pathogenic ...
Taken together, the viruses that cause VHFs are distributed over much of the globe. However, because each virus is associated with one or more particular host species, the virus and the disease it causes are usually seen only where the host species live(s). Some hosts, such as the rodent species carrying several of the New World arenaviruses, live in geographically restricted areas. Therefore, the risk of getting VHFs caused by these viruses is restricted to those areas. Other hosts range over continents, such as the rodents that carry viruses which cause various forms of hantavirus pulmonary syndrome (HPS) in North and South America, or the different set of rodents that carry viruses which cause haemorrhagic fever with renal syndrome (HFRS) in Europe and Asia. A few hosts are distributed nearly worldwide, such as the common rat. It can carry Seoul virus, a cause of HFRS; therefore, humans can get HFRS anywhere where the common rat is found.. While people usually become infected only in areas ...
Argentine hemorrhagic fever (AHF) was recognized as a new clinical entity from the richest farming region of Argentina in the 1950s (Arribalzaga 1955). The etiologic agent of this disease, Junin virus
These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms.
Los síndromes infecciosos asociados a arenavirus en América del sur son cuatro: síndrome febril de origen viral; fiebres hemorrágicas con o sin compromiso neurológico; meningitis asépticas y meningo-encefalitis. Entre los Arenavirus del nuevo mundo, está el complejo Tacaribe donde se encuentran los virus: Junín (Argentina), Guanarito (Venezuela), Machupo (Bolivia) y Sabiá (Brasil), que se caracterizan por causar fiebres hemorrágicas. En Colombia fue aislado el arenavirus Pichindé en 1965, del roedor Oryzomys albigularis, en el valle de Pichindé (Valle del Cauca). Este arenavirus produce una infección persistente en su hospedero y no es patógeno para el hombre. Hay evidencias de la circulación del virus Guanarito en roedores de Córdoba, pero no existen casos diagnosticados en humanos; en Sincelejo (Colombia) se detectó el genoma del virus coriomeningitis linfocítica en cerebros de roedores Mus musculus. El diagnóstico se basa en el conocimiento de la epidemiología local y la sospecha
BACKGROUND INFORMATION ABOUT CONVALESCENT PLASMA: Passive immunity has proven effective for cytomegalovirus (CMV), hepatitis B virus, rabies, tetanus, varicella, certain SARS variants, Argentine Hemorrhagic Fever, and various other illnesses. Convalescent plasma has been cited as a potential therapy for viral infection dating back to the 1918 Spanish influenza A (H1N1) pandemic. Since that time, convalescent plasma as passive immune therapy has been evaluated in the treatment of: Ebola, SARS coronavirus (SARS-CoV), 2009 pandemic influenza A (H1N1), Argentine Hemorrhagic Fever, CMV, Parvovirus B19, and others. Furthermore, a February 2020 WHO report states "The cellular infectivity of the isolated viruses could be completely neutralized by the sera collected from convalescent patients." [Source: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf ] ABOUT CERUS Cerus Corporation is dedicated solely to safeguarding the worlds blood supply and ...
Junin virus buds at CD9-enriched sites. JUNV-A647 viral particles stained with either a CD9 antibody conjugated to PE (a) or Cholera Toxin B (CTB) conjugated to
American Whitewater is the primary advocate for the preservation and protection of whitewater rivers throughout the United States and connects the interests of human-powered recreational river users with ecological and science-based data to achieve goals within our mission.
American Whitewater is the primary advocate for the preservation and protection of whitewater rivers throughout the United States and connects the interests of human-powered recreational river users with ecological and science-based data to achieve goals within our mission.
Participate in a whitewater trip using either a canoe or kayak on a Class I or Class II river. Help to prepare a written plan, specifying the route, schedule, equipment, safety precautions, and emergency procedures. Determine local rules and obtain permission from landowners and land managers in advance. Explain what steps you have taken to comply with BSA Safety Afloat and the American Whitewater safety guidelines. Execute the plan with others ...
Participate in a whitewater trip using either a canoe or kayak on a Class I or Class II river. Help to prepare a written plan, specifying the route, schedule, equipment, safety precautions, and emergency procedures. Determine local rules and obtain permission from landowners and land managers in advance. Explain what steps you have taken to comply with BSA Safety Afloat and the American Whitewater safety guidelines. Execute the plan with others ...
Boid inclusion body disease (BIBD) is a viral disease of boid snakes believed to be caused by reptarenavirus belonging to the family Arenaviridae. Unlike most mammalian arenaviruses, the reservoir host for reptarenavirus is still unknown. In this study, the pathological responses were evaluated in a mouse model for a period of 28 days. Blood and tissue samples (lung, liver, spleen, heart, kidney and brain) were collected for evaluation of hematology, biochemistry, histopathology and oxidative enzyme levels at six time points (1, 3, 7, 14, 21 and 28 days), after viral infection (2 ...
A Ohio woman who went whitewater rafting in North Carolina has died of an infection after being exposed to an amoeba that is naturally present in warm, fresh water.
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Everything you need to know-detailed itinerary, packing list, pre- & post-trip lodging, and more-for California Whitewater Guide School with OARS.
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When Eddie Arroyo was an 18-year-old working in a gas station at the corner of Fifth Avenue and Jackson Boulevard, some of his customers who frequented the racetrack suggested that he think about
Currently there are relatively few antiviral therapeutics, and most which do exist are highly pathogen-specific or have other disadvantages. We have developed a new broad-spectrum antiviral approach, dubbed Double-stranded RNA (dsRNA) Activated Caspase Oligomerizer (DRACO) that selectively induces apoptosis in cells containing viral dsRNA, rapidly killing infected cells without harming uninfected cells. We have created DRACOs and shown that they are nontoxic in 11 mammalian cell types and effective against 15 different viruses, including dengue flavivirus, Amapari and Tacaribe arenaviruses, Guama bunyavirus, and H1N1 influenza. We have also demonstrated that DRACOs can rescue mice challenged with H1N1 influenza. DRACOs have the potential to be effective therapeutics or prophylactics for numerous clinical and priority viruses, due to the broad-spectrum sensitivity of the dsRNA detection domain, the potent activity of the apoptosis induction domain, and the novel direct linkage between the two which
Missing Vial of Dangerous Virus Highlights Security Problems at U.S. Labs. WS - Theyre are No numbers available for Corporations that are fuc$ing with deadly viruses. With the US taxpayer funding research for private corporations at Colleges and Universities, "plausible deniability", will shield the corporations should diseases of mass destruction get released, by espionage, accident or human testing. - Just sayin.. Lets start with the good news: The vial of Guanarito, a rare disease found only in Venezuelan rodents, that was reported missing from a Texas lab on Wednesday is probably nothing to worry about. First of all, theres no evidence that Guanarito can be transmitted from person to person-only from rodent to person (though when that happens, primarily to "male agricultural workers," it isnt pleasant). Nor does it appear that the vial was spirited away by an evildoer-more likely, itl was destroyed after accidentally falling to the floor, Galveston National Laboratory scientific ...
I hope the term dry scalp didnt make you cringe. Ive suffered from it for years. I think part of it is my fault. I finally wised up and am not having problems with it anymore. I was one of those people that would wash my hair EVERY SINGLE DAY. Yep, winter, spring, summer, and…
Wanna live where the action is? The goal: Trails out the back door, a serious Saturday-morning peloton, whitewater just up the road, and neighbors eager to join in. Our source: The best adventure athletes in America, who tell us where they live and why. The result: 20 places where locals work, train, and play hard. Start packing now.
About 200 gallons of untreated sewage spilled into the Arroyo Conejo, causing city officials to post warning signs Tuesday up to one mile downstream.The spill into the creek was caused when a
How do you explain the discovery of the new world by Europeans? Was it an accident, good luck, or the result of a more complex set of.
Выберите интересующий Вас раздел: 0-9 B C D E F G H I L M O R S T V W А Б В Г Д Е Ж З И К Л М Н О П Р С Т У Ф Х Ц Ч Ш Щ Э Ю Я TOP 20... [Read More] Tracked on Aug 15, 2006 10:14:28 PM. ...
Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean?
Local resource for horse veterinarians in Whitewater. Includes detailed information on local clinics that provide access to horse veterinarians, as well as advice and content on horseback care, animal healthcare, and horse grooming.
The nuclear gene phytochrome A (PHYA) from 71 species of crown clade Apocynaceae (subfamilies Asclepiadoideae, Secamonoideae, Periplocoideae, and four lineages of Apocynoideae) and outgroups is used to (1) test the chloroplast phylogeny that places the African tribe Baisseeae, with solitary pollen grains, as sister to the pollinia-bearing milkweeds (Secamonoideae plus Asclepiadoideae); (2) resolve the position of tetrad-bearing Periplocoideae, the proposed milkweed sister group based on morphology; (3) place the enigmatic Dewevrella; and (4) clarify relationships of the three other primary crown clade lineages: Rhabdadenia, New World clade, and Asian clade. Separate analyses of PHYA and chloroplast sequences agree in placing an African monad-bearing clade (Baisseeae plus Dewevrella) as the sister group of the milkweeds. Combined PHYA and chloroplast datasets under parsimony and maximum likelihood reject Periplocoideae as the milkweed sister group with statistical significance. Rhabdadenia is ...
It is believed that most infections with Lassa virus never go beyond "flu-like" illness. Of all Arenaviruses only LCMV, Junin, Machupo, Guanarito, Lujo and Lassa viruses have demonstrated the ability to confer human disease ranging from the onset of neurologic diseases or hemorrhagic fevers of varying severity.. The clinical presentation of Lassa fever usually begins with insidious progression of fever and general malaise that can progress to more severe symptoms within 1-2 weeks. Hepatitis (inflammation of the liver) is frequent and moderately severe in Lassa fever. Hemorrhaging, leukopenia and thrombocytopenia as well as neurologic signs are not quite as common in Lassa fever as compared to other hemorrhagic fevers such as Ebola and Marburg. Viral particles can be found in the blood of patients up to three weeks after the onset of infection and Lassa virus can be recovered from the urine for several weeks more.. Common symptoms associated with cases of Lassa fever include fever, sore throat, ...
The established animal model for Lassa fever is based on the new world arenavirus Pichinde (PIC). Natural isolates of PIC virus are attenuated in guinea pigs, but serial guinea pig passage renders them extremely virulent in that host. We have compared the nucleotide sequences of the small RNA segments of two attenuated, low-passage variants of the PIC virus Munchique strain (CoAn 4763) and two virulent, high-passage derivatives. Missense mutations in the glycoprotein precursor (GPC) gene at codons GPC-119, GPC-140, and GPC-164 and the nucleoprotein gene (NP) codons NP-35 and NP-374 were most closely associated with virulence. Codon GPC-140 is predicted to represent a region of peak hydrophilicity of the glycoprotein 1 (GP1); it is conceivable that mutations at this site could influence virulence by altering B cell epitopes or virus attachment protein conformation.
Viral hemorrhagic fevers (VHFs) caused by arenaviruses are acute diseases characterized by fever, headache, general malaise, impaired cellular immunity, eventual neurologic involvement, and hemostatic alterations that may ultimately lead to shock and death. The causes of the bleeding are still poorly understood. However, it is generally accepted that these causes are associated to some degree with impaired hemostasis, endothelial cell dysfunction and low platelet counts or function. In this article, we present the current knowledge about the hematological alterations present in VHF induced by arenaviruses, including new aspects on the underlying pathogenic mechanisms.
Get the Arroyo Hondo afternoon weather forecast for today, tomorrow and 15 days including the afternoon high temperature, RealFeel and chance of precipitation for Arroyo Hondo, Dominican Republic from AccuWeather.com
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Im finding out so much. The vaccine for Argentine Hemorrhagic Fever was created by Julio Barrera Oro in 1985. This virus kills about 30 % of the people that contract it and is spread by contact with the droppings of a small mouse. When the virus was isolated, almost simultaneously by two opposing institutions in Buenos Aires, the competition for who found it first was so severe that Julio Barrera Oro inoculated himself with this potentially lethal virus to show his team really had found it. A few days later he developed the fever. Luckily he survived ...
WHITEWATER, Wis. (Blugolds.com) - In a game that featured five field goals, the UW-Eau Claire football team hung right with UW-Whitewater but came up short 19-10 at Perkins Stadium today.. In the first quarter, the Warhawks took the initial lead after kicking a 28-yard field goal but the Blugolds tied it up with a 33-yard field goal by Josh Albrecht (Sr.-Eau Claire, Wis./North) with 44 seconds left in the quarter.. Whitewater kicked another field goal, this one from 24 yards, early in the second quarter to take a 6-3 advantage.. The two teams finally found the end zones before halftime. Whitewater scored a two-yard rushing touchdown to take a 13-3 lead but the Blugolds answered with less than a minute remaining in the half to make the halftime score 13-10. Austin Neu (Sr.-Iron Ridge, Minn./Hustisford) capped off an 11-play, 78-yard drive with a 23-yard touchdown pass to Cody Gerver (So.-Mahtomedi, Minn.).. In the second half, the Blugolds were held scoreless while Whitewater kicked two more ...
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Information about Whitewater WI cellular biology. Qualifications for healthcare programs vary widely. Learn about the various medical specializations available within technical training programs.
Arroyo Murciélago (San Pedro Ixcatlán, Oaxaca, Mexico) with population statistics, charts, map, location, weather and web information.
La Unión y El Cardonal (Doctor Arroyo, Nuevo León, Mexico) with population statistics, charts, map, location, weather and web information.
Arab News. A Sword of Damocles Over the Head of Arroyo?. by Manuel L. Quezon III. There used to be a saying, in the 1960s, that in the Philippines the three most important people were the US ambassador, the head of the industrialist Lopez family, and the president of the Philippines.. In that order. That was an exaggeration, of course, but the stampede of the Philippine political class to attend the US Embassys annual July 4 reception attests to how important the United States is to Filipino leaders. Of course a fixation with what America thinks or does is not uniquely Filipino: They are the sole remaining superpower. However, Filipino leaders have been criticized by their own countrymen for taking tail-wagging to an extreme matched only by British Prime Minister Tony Blair.. Recently, in a ceremony in the Philippine presidential palace, US Ambassador Kristie Kenney said something interesting. Speaking in the presence of the president, the American ambassador said that they would be closely ...
In ICF whitewater slalom paddlers negotiate their way down a 300 m (980 ft) of whitewater rapids, through a series of up to 25 gates (pairs of hanging poles.) The colour of the poles indicates the direction in which the paddlers must pass through; time penalties are assessed for striking poles or missing gates. Categories are C1 (solo) and C2 (tandem), the latter for two men, and C2M (mixed) for one woman and one man.[39] C1 boats must have a minimum weight and width of 10 kg (22 lb) and 0.65 m (2 ft 2 in) and be not more than 3.5 m (11 ft) long. C2s must have a minimum weight and width of 15 kg (33 lb) and 0.75 m (2 ft 6 in), and be not more that 4.1 m (13 ft). Rudders are prohibited. Canoes are decked and propelled by single-bladed paddles, and the competitor must kneel.[40]. In ICF wildwater canoeing athletes paddle a course of class III to IV whitewater (using the international scale of river difficulty), passing over waves, holes and rocks of a natural riverbed in events lasting either ...
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7. GMA needs somebody young and energetic. Baka tumanda agad si Gloria dahil lagi na lang sina FVR, JDV, Nograles, at Pichay ang kasama niya ...
iframe src="https://biblio.ugent.be/person/802001725222?embed=1&hide_pagination=1&hide_info=1&hide_options=1&hide_cluster=1" ...
Mentor: Dr. José E. García-Arraras; University of Puerto Rico, Rio Piedras Campus. Project: Characterization of Novel Markers in Holorituria Glaberrima Nervous System. ...
A video about author Russ Normandy - 29 views - 0 people liked it. Harper witnesses a mobster murder, but will not agree to testify. For insurance, the m...
Type: American Dry, Grain, Grain Base, Hand-Crafted New World Gin, Micro Distilled, New York State It doesnt get more exotic, organic or complex than this gin.Not a London Dry but a New World Gin using more exotic ingredients than anyone else and all of them organic.. ...
I do a bit of whitewater stuff and hike, ski and drive during the wet. I like getting stuck into the deep bush wherever possible (occasionally find something new to climb). Its the same feeling as being 1/2way up a good, long multi-pitch: isolation, but still being immersed in the world ...
Answer 1 of 16: Hi. We are travelling to the Arenal area, and will be staying at a few different hotels over our week-long trip there. (Tree Houses Hotel, AOL, and The Springs). We have not pre-booked any actitivies but plan on doing zip-lining and whitewater...
Describes the true nature of evil, its role in the evolution of the Cosmos and in the ancient agenda of secret societies to create a New World Order with its One World Government and One World Religion
Describes the true nature of evil, its role in the evolution of the Cosmos and in the ancient agenda of secret societies to create a New World Order with its One World Government and One World Religion
What are the best jobs to have in 2018? U.S. News & World Report compiled a list of careers using a two-part process. First, jobs
Join today and immidiately join the conversation! Already have an account? Log in now.. Its easy. Use an existing account. Or simply Create an Account with New World Wine Maker.. ...
... Harvard Transition 2011 Symposium: Clarifying Goals, Mobilizing Support, Taking Action January 11-13, 2…
Business execs are playing a bigger role in buying technologies to help their firms win, serve, and retain customers. CIOs still play a major role, but they operate in a new world of shifting.... ...
Columbia University Department of Surgery is conducting hundreds of clinical trials to improve care for many types of conditions.. Use the tool below to find our clinical trials that are currently enrolling new patients. Each listing explains the purpose of the trial, links to the investigators biography, the trials eligibility criteria, and how to get more information.. ...
Pichinde virus (PIC) is a reticuloendothelial arenavirus of the New World tropics. A guinea pig passage-adapted strain of this virus (adPIC) is uniformly lethal for inbred guinea pigs, while the related, prototype strain (PIC3739) has attenuated virulence. The abilities of adPIC and PIC3739 to induce tumor necrosis factor (TNF) in vivo and in cultured macrophages were compared. Infection with adPIC, but not PIC3739, was associated with detectable serum TNF that peaked in week 2 of infection. Tumor necrosis factor was found in the spleens of adPIC- and PIC3739-infected animals in week 1 of infection ; TNFα mRNA levels in spleens and livers of adPIC infected animals increased and remained high throughout infection, whereas PIC3739-infected organs showed down regulation of TNFα mRNA late in infection. Peritoneal macrophages explanted from adPIC-infected animals showed enhanced lipopolysaccharide-inducible TNF production. Altered regulation of TNF production may play a role in the pathogenesis of guinea
IN THE UNITED STATES DISTRICT COURT FOR THE WESTERN DISTRICT OF TEXAS EL PASO DIVISION ROBERT ARROYO, Plaintiff, v. NANCY A. BERRYHILL, Acting Commissioner of Social Security Administration, Defendant. § § § § § § § § NO. EP-16-CV-0460-LS MEMORANDUM OPINION AND ORDER Plaintiff Robert Arroyo appeals the denial of his application for disability insurance benefits under 42 U.S.C. § 405(g). The parties consent to my determination of the case under 28 U.S.C. § 636(c) and Appendix C to the Local Court Rules for the Western District of Texas. I REVERSE and REMAND the Commissioner=s decision denying Romeros application. I. Facts and Proceedings Arroyo alleges he became disabled on January 15, 2014 because of depression, osteoarthritis, sleep apnea, and hearing problems. 1 An Administrative Law Judge ("ALJ") held a hearing on June 21, 2016 2 and heard testimony from Arroyo, who was represented by counsel, and from a vocational expert. In an opinion dated July 5, 2016, the ALJ determined that ...
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Lymphocytic Choriomeningitis (LCM) Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae that was initially isolated in 1933. The primary host of LCMV is the common house mouse, Mus musculus. Infection in house mouse populations may vary by geographic location, though it is estimated that 5% of house mice throughout the United States carry LCMV and are able to transmit virus for the duration of their lives without showing any sign of illness. Other types of rodents, such as hamsters, are not the natural reservoirs but can become infected with LCMV from wild mice at the breeder, in the pet store, or home environment. Humans are more likely to contract LCMV from house mice, but infections from pet rodents have also been reported.. LCMV infections have been reported in Europe, the Americas, Australia, and Japan, and may occur wherever infected rodent hosts of the virus are found. The ...
... SAN DIEGO and BRISBANE Calif. March 3...View this information on the law firms Shareholder Rights Blog: Is the Proposed Acquisition Best for Hyperion Therapeutics Inc. an...Robbins Arroyo LLPs investigation focuses on whether the board of dir...,Robbins,Arroyo,LLP:,Acquisition,of,Hyperion,Therapeutics,,Inc.,(HPTX),by,Horizon,Pharma,plc,(HZNP),May,Not,Be,in,Shareholders,Best,Interests,medicine,advanced medical technology,medical laboratory technology,medical device technology,latest medical technology,Health
Water at the U.S. National Whitewater Center in CHarlotte, NC have tested positive for a brain-eating amoeba responsible for the death of an 18-year-old Ohio girl, according to Mecklenburg County Commissioners.
Diana Schunn got into nursing at the beginning of a paradigm shift, and shes continued to push for progress.Schunn, of Whitewater, is the recipient of Bethel Colleges 2019 Distinguished Achievement Award, which acknowledges character and citizenship, achievement in a chosen profession or vocation, and work of benefit to humanity. She will receive the award at the colleges annual Alumni Banquet, June 8 during Alumni Heritage Weekend on campus. Schunn received her
Other Water Sports in Cañon City: Check out 333 reviews and photos of Viators Bighorn Sheep Canyon Half Day Whitewater Experience
The latest trends and statistics to help you find the top accredited small business programs in Whitewater, Wisconsin. Insight on students, faculty and small business professional salaries.
The most relevant trends and data to help you find the top accredited social work schools in Whitewater, Wisconsin. Information on students, faculty and social worker salaries.
Rodent-borne pathogens like hantaviruses and arenaviruses are simple, but resourceful, and very successful at propagating. Due to a tiny genome generating a mere four proteins compared to humans thousands, they rely on human biological machinery to do their replication dirty work, facilitating infection, plus a high mortality rate. Vermont researchers have discovered a mechanism that when targeted, may stop these deadly viruses in their tracks.. A new study published in Cell Host & Microbe by the University of Vermonts Jason Botten, Ph.D., assistant professor of medicine and microbiology and molecular genetics, and graduate student Joseph Klaus and colleagues offers a paradigm shift for scientists understanding of the functionality of a protein that resides in the cells secretory pathway and gets "shuttled" from one end of the cell to the other.. Antivirals or vaccines do not exist for these pathogens, so gaining a better understanding of how they replicate was at the heart of Botten and ...
The Supreme Court has previously sided with Arroyo, ruling last month that she is eligible to run for senate [JURIST report] after her presidential term expires. The court found the law requiring appointed officials to resign when they declare their candidacy for elected office is constitutional, but that the ruling does not affect elected officials. Also last month, the Philippine Department of Justice (PDOJ) [official website] charged 197 people with murder [JURIST report] in connection with the November massacre in the semi-autonomous Maguindanao province that left 57 dead. Among those charged is Andal Ampatuan Sr., a former political ally to Arroyo, head of a Muslim clan, and former governor of Maguindanao province. Following the killings, Arroyo imposed martial law [JURIST report] and suspended habeas corpus in the province. She later lifted the conditions, following international pressure and domestic legal challenges [JURIST reports]. ...
Standardization of an ELISA test using a recombinant nucleoprotein from the Junin virus as the antigen and serological screening for arenavirus among the population of Nova Xavantina, State of Mato Grosso ...
Human transferrin receptor, molecular model. This molecule is found on the surface of a cell. It binds transferrins, iron-binding glycoproteins found in the blood plasma, and transports them into the cell. - Stock Image F009/6016
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Arenaviruses are feared as agents that cause viral hemorrhagic fevers. We report the identification, isolation, and genetic characterization of 2 novel arenaviruses from Namaqua rock mice in Namibia. These findings extend knowledge of the distribution and diversity of arenaviruses in Africa.
Lymphocytic choriomeningitis (LCM) is a rodent-borne viral infectious disease that presents as aseptic meningitis, encephalitis or meningoencephalitis. Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae. The name was coined by Charles Armstrong in 1934. The Gale Encyclopedia of Medicine defines lymphocytic choriomeningitis (LCM) as "a viral infection of the membranes surrounding the brain and spinal cord and of the cerebrospinal fluid". The name is based on the tendency of an individual to have abnormally high levels of lymphocytes during infection. Choriomeningitis is "cerebral meningitis in which there is marked cellular infiltration of the meninges, often with a lymphocytic infiltration of the choroid plexuses". There are several strains of LCM virus, among which the most widely used are LCMV Armstrong and LCMV Clone 13. Armstrong is the original virus strain which was isolated from the brain by Charles Armstrong in 1934. It triggers a ...
Viral hemorrhagic fever (VHF) is a severe multiorgan disease with strong immune involvement and diffuse vascular dysregulation, particularly of the vascular endothelium. Several families of RNA viruses are regularly associated with a VHF syndrome in humans: Arenaviridae (Lassa virus, Machupo virus, Junin virus, Guanarito virus, and Sabia virus), Bunyaviridae (Rift Valley fever virus, Crimean-Congo hemorrhagic fever virus, hantaviruses), Flaviviridae (Yellow fever virus, Dengue virus, Omsk hemorrhagic fever virus, and Kyasanur forest disease virus), and Filoviridae (Marburg virus and Ebola virus). The clinical manifestations of VHF vary and are dependent on the causative agent (see CDC homepage http://www.cdc.gov). However, some common clinical features include fever, various degrees of vascular dysregulation with bleeding tendency and shock development, and the vascular endothelium seems to be affected in most cases (1-3). Some of the VHF-causing pathogens target the endothelium directly, ...
FILED IN CLERKS OFFICE US DISTRICT COURT E.D.N.Y. UNITED STATES DISTRICT COURT EASTERN DISTRICT OF NEW YORK * JAN 1 1 2018 * BROOKLYN OFFICE GUSTAVO ARROYO Plaintiff, - against - POLICE OFFICER CARMINE BELLAMORE, ET AL, DECISION AND ORDER 13-cv-5228 (AMD)(A YS) Defendants. ANN M. DONNELLY, District Judge. The pro se plaintiff, Gustavo Arroyo, brings this civil rights action against police officers Carmine Bellamore and James Crawford, under 42 U.S.C. § 1983, in their individual and official capacities. The plaintiff filed his initial complaint on September 13, 20 13. (ECF No. 1.) 1 On April 2 1, 2017, the plaintiff moved to amend his complaint to add the County of Nassau as a defendant, and three claims of municipal liability. (ECF No. 49-2 at 1.) On June 23, 20 17, Magistrate Judge Ann Shields issued a Report and Recommendation (" R&R"), denying the plaintiffs request to file an amended complaint. (ECF No. 58.) The plaintiff obj ected to the R&R on August 11 , 20 17. (ECF No. 64.) Based on my ...
World Health Organization. World Health Organization. August 2014. Archived (PDF) from the original on 21 August 2014. ... arenaviruses, and flaviviruses" (PDF). Ministry of Health and Long-Term Care. Archived (PDF) from the original on 15 October ... WHO: Ebola haemorrhagic fever - World Health Organization, Global Alert and Response. *[1] - World Health Organization, Fact ... World Health Organization. Archived from the original on 29 July 2014.. *^ a b c "Monitoring Symptoms and Controlling Movement ...
World Health Organisation report, 24 September 2014 *^ Einstein MH, Schiller JT, Viscidi RP, Strickler HD, Coursaget P, Tan T, ... Examples include geminiviruses, which are ssDNA plant viruses and arenaviruses, which are ssRNA viruses of animals.[94] ... The evidence for an ancestral world of RNA cells[62] and computer analysis of viral and host DNA sequences are giving a better ... The ancient Virus World and evolution of cells. Biology Direct. 2006;1:29. doi:10.1186/1745-6150-1-29. .mw-parser-output cite. ...
Arenavirus: Guanarito virus,[2] Junín virus,[2] Lassa fever virus,[2] Lujo virus,[3] Machupo virus[2] ve Sabiá virus[2] ... "World J. Gastroenterol. 16 (6), s. 698-702. PMC 2817057 $2. PMID 20135717.. KB1 bakım: Birden fazla ad: yazar listesi (link) ... "World J Hepatol. 3 (4), s. 83-92. doi:10.4254/wjh.v3.i4.83. PMC 3098392 $2. PMID 21603030.. ... "Genetic detection and characterization of Lujo virus, a new hemorrhagic fever-associated arenavirus from southern Africa" ...
The life cycle of Lassa virus is similar to the Old World arenaviruses. Lassa virus enters the cell by the receptor-mediated ... It shares this receptor with the prototypic Old World arenavirus lymphocytic choriomeningitis virus. Receptor recognition ... the New World arenaviruses of clades A and B, which include the important viruses Machupo, Guanarito, Junin, and Sabia in ... a b Donaldson, Ross I. (2009). The Lassa Ward:One Man's Fight Against One of the World's Deadliest Diseases. St. Martin's Press ...
World Health Organization. Archived from the original on 3 December 2013. Retrieved 2 April 2013.. ... Louis encephalitis, West Nile encephalitis virus), bunyavirus (La Crosse strain), arenavirus (lymphocytic choriomeningitis ... World Health Organization. Archived from the original on 3 December 2013. Retrieved 2 April 2013.. ...
Lassa virus is a member of the Arenavirida family of viruses.[7] Specifically it is an old world arenavirus, which is enveloped ... "World Health Organization. Retrieved 2017-09-11.. *^ McCormick, J. B.; King, I. J.; Webb, P. A.; Scribner, C. L.; Craven, R. B ... "World Health Organization. 1 March 2018.. *^ Kieny, Marie-Paule. "After Ebola, a Blueprint Emerges to Jump-Start R&D". ... World Health Organization. April 2017. Retrieved 11 September 2017.. *^ Centers for Disease Control and Prevention, "Lassa ...
"Fatal Illnesses Associated With a New World Arenavirus --- California, 1999--2000". MMWR Weekly. Fulhorst, Charles; Charrel, ... Arenavirus-specific RNA was detected in each patient using RT-PCR. The nucleotide sequence of the patients were essentially ... Like other arenaviruses, WWAV appears to be transmitted through rodents. Therefore, direct contact with rodents, their feces, ... Although it is unclear if WWAV can be transmitted nosocomially, other arenaviruses have been transmitted through contact with ...
Arenaviruses. Elsevier. p. 7. ISBN 9780080877372. Zuckerman 2014, p. 10 "Viral Hemorrhagic Fevers Caused by Arenaviruses" (PDF ... It is a member of Clade A of the Tacaribe (or "New World") serocomplex of the family Arenaviridae. Laboratory workers infected ... an arenavirus with a mammalian host. It was first found in semiaquatic rodents of the genus Oryzomys in tropical forest in the ...
World Health Organization, Global Alert and Response [1] - World Health Organization, Fact Sheet 103 Ebola Virus Disease, ... arenaviruses, and flaviviruses" (PDF). Ministry of Health and Long-Term Care. Archived (PDF) from the original on 15 October ... World Health Organization. World Health Organization. August 2014. Archived (PDF) from the original on 21 August 2014. ... Urging the world to offer aid to the affected regions, the Director-General said, "Countries affected to date simply do not ...
... arenavirus.pdf, last updated: February 23, 2010. Aguilar PV, Carmago W, Vargas J, Guevara C, Roca Y, Felices V, et al. ... The Chilling True Story of the Largest Covert Biological Weapons Program in the World - Told from Inside by the Man Who Ran It ... Viral Hemorrhagic Fevers Caused by Arenaviruses, http://www.cfsph.iastate.edu/Factsheets/pdfs/viral_hemorrhagic_fever_ ...
... arenavirus MeSH B04.820.057.070.100 --- arenaviruses, old world MeSH B04.820.057.070.100.500 --- lassa virus MeSH B04.820. ... arenavirus MeSH B04.909.777.080.070.100 --- arenaviruses, old world MeSH B04.909.777.080.070.100.500 --- lassa virus MeSH ... 057.070.100.550 --- lymphocytic choriomeningitis virus MeSH B04.820.057.070.800 --- arenaviruses, new world MeSH B04.820. ... B04.909.777.080.070.100.550 --- lymphocytic choriomeningitis virus MeSH B04.909.777.080.070.800 --- arenaviruses, new world ...
He discovered more novel viruses than any person previously, including members of the Arenavirus, Hantavirus, Lyssavirus and ... World Renowned Authority on Infectious Diseases, Robert E. Shope", YaleNews, Yale University, February 4, 2004, retrieved ... His group identified alphavirus, arenavirus and flavivirus as potential bioterrorist risks, and Shope worked with structural ...
As receptors for phosphatidylserine, TIM proteins bind many families of viruses [filovirus, flavivirus, New World arenavirus ...
Sessa R, Palagiano C, Scifoni MG, di Pietro M, Del Piano M. The major epidemic infections: a gift from the Old World to the New ... Examples include geminiviruses, which are ssDNA plant viruses and arenaviruses, which are ssRNA viruses of animals. Genome size ... The ancient Virus World and evolution of cells. Biology Direct. 2006;1:29. doi:10.1186/1745-6150-1-29. PMID 16984643. Dimmock p ... There are only two centres in the world that are authorised by the WHO to keep stocks of smallpox virus: the State Research ...
Washington, D.C., U.S.A: Pan American Health Organization, Pan American Sanitary Bureau, Regional Office of the World Health ... Arenaviruses. Intervirol. 4, 207-213. Gernot H. Bergold (1911-2003) (PDF Download Available). Available from: https://www. ... Disease card on World Organisation for Animal Health. ...
Prevalence of antibodies to arenaviruses in rodents from the southern and western United States: evidence for an arenavirus ... eds.). Orders and families of Recent mammals of the world. John Wiley and Sons, New York, 686 pp. Carleton, M.D. and Musser, G. ... An arenavirus normally associated with woodrats (Neotoma) has also been found in Florida marsh rice rats. Antibodies against ... 894-1531 in Wilson, D.E. and Reeder, D.M. (eds.). Mammal Species of the World: a taxonomic and geographic reference. 3rd ed. ...
Musser, G.G.; Carleton, M.D. (2005). "Superfamily Muroidea". In Wilson, D.E.; Reeder, D.M. Mammal Species of the World: A ... "Principal host relationships and evolutionary history of the North American arenaviruses". Virology. Elsevier. 367 (2): 235-243 ...
The INEVH has performed research for the World Health Organization since 1985 and currently specializes in four areas: ... Arenaviruses Arboviruses Hantavirus Production of biological specimens ANLIS (in Spanish) Archived 2006-10-04 at the Wayback ...
He is a member of the World Health Organization Collaborating Center for Tropical Diseases. He is also director for biodefense ... His arenavirus research concentrates on the effects of infection on cellular function, particularly those molecular ... Peters, C. J. and Mark Olshaker (1998), Virus Hunter: Thirty Years of Battling Hot Viruses Around the World, Random House. ... of viral diseases including more than 70 publications on Rift Valley fever virus and more than 60 publications on arenaviruses ...
Sequencing of the viral genome has shown that this virus belongs to the Old World arenavirus group. Comparisons with other ... viral genome sequences showed that this virus is equidistant from other Old World and New World arenaviruses. It is distantly ... identified the etiological agent of the outbreak as an Old World arenavirus using molecular and serological tests. Sequencing ... "Discovery of new arenavirus associated with hemorrhagic fever - first identified in nearly four decades". News-Medical.net. ...
It has particular importance to farmers in certain regions of the world where it can infect cattle. This is because its ... Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses ... Disease card on World Organisation for Animal Health. ...
Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World-Told from Inside by the Man ... "Properties of Replication-Competent Vesicular Stomatitis Virus Vectors Expressing Glycoproteins of Filoviruses and Arenaviruses ... This isolation strongly suggests that Old World fruit bats are involved in the natural maintenance of marburgviruses and that ... Marburgviruses are World Health Organization Risk Group 4 Pathogens, requiring Biosafety Level 4-equivalent containment, ...
Arenaviruses are divided into two groups: the Old World and the New World viruses. The differences between these groups are ... termini of the virion RNA species of New World and Old World arenaviruses". Virology. 121 (1): 200-3. doi:10.1016/0042-6822(82) ... At least eight arenaviruses are known to cause human disease. The diseases derived from arenaviruses range in severity. Aseptic ... The life cycle of the arenavirus is restricted to the cell cytoplasm. Within the family Arenaviridae, arenaviruses were ...
The island of Vir in Croatia is one of the biggest described endemic places of origin of LCMV in the world, with IFA testing ... The first arenavirus, lymphocytic choriomeningitis virus (LCMV), was isolated in 1933 by Charles Armstrong during a study of an ... World Health Organ. 55 (5): 599-603. PMC 2366689 . PMID 338190. ICTVdB-The Universal Virus Database, version 4. [2] Centers for ... LCMV has been shown to cause illness in New World primates such as macaques, marmosets and tamarins. Infections have also been ...
Most deaths are due to hepatitis B and hepatitis C. East Asia is the region of the world most affected. Play media The most ... Other viruses than can cause hepatitis include: Adenoviruses Arenaviruses: Guanarito virus, Junín virus, Lassa fever virus, ... This occurs primarily in third world countries. Strict personal hygiene and the avoidance of raw and unpeeled foods can help ...
... and Arenaviruses (Lassa Fever) and collaborative projects with the U.S. Army to develop therapies for Ebola and Lassa viruses. ... and possibly aid in the detection of DNA-based life elsewhere in the universe." She returned to Earth on October 30, 2016 after ...
Biohazard: The Chilling True Story of the Largest Covert Biological Weapons Program in the World-Told from Inside by the Man ... "Properties of Replication-Competent Vesicular Stomatitis Virus Vectors Expressing Glycoproteins of Filoviruses and Arenaviruses ... Garrett, Laurie (1994). The Coming Plague: Newly Emerging Diseases in a World Out of Balance. New York, USA: Farrar, Straus & ... Marburgviruses are World Health Organization Risk Group 4 Pathogens, requiring Biosafety Level 4-equivalent containment,[51] ...
World News. Regenerative Medicine Journal. Point Of View. Regenerative Medicine Journal. Enhancement of abiraterone acetate ... fourier transform infrared spectroscopy Crystal structure of the prefusion surface glycoprotein of the prototypic arenavirus ... bridging biological networks with the electronic digital world Persistent gamma spiking in SI nonsensory fast spiking cells ... progression in breast cancer using somatic mutations and copy number aberrations Lyme disease ecology in a changing world: ...
For each bacteria or virus that has been sequenced anywhere in the world, we have several dozen squares on the checkerboard ... Examples of (-)-strand RNA viruses include arenaviruses (e.g., sabia virus, lassa fever, Machupo, Argentine hemorrhagic fever, ...
Arenaviruses, New World Outcome. Arenaviridae Infections Bioterrorism Hemorrhagic Fever, Ebola Hantavirus Infections ...
Arboviruses Arenaviruses can You Get Cytotec Without A Prescription at the can You Get Cytotec Without A Prescription. As an ...
CSTA will be bringing its world class professional development and educator community together again in July of 2018. They are ... arenaviruses, HIV/AIDs, Chikungunya virus, Burkitts lymphoma, and aging. ...
It is the leading cause of viral gastroenteritis in the world!. Never heard of it :O. Is it the same as Norwalk virus? ... Arenavirus. Bunyavirus. Coronavirus?. Correct! Review question: Does anyone know the clinical significance of the segmented ...
Arenavirus Receptors * Coronavirus Receptors * Filovirus Receptors * Flavivirus Receptors * Herpesvirus Receptors * ...
Arenaviruses, New World Cytochromes B Humans Immunoassay Immunoglobulin G Letters To The Editor Rodent Diseases Rodentia Viral ... Arenavirus RNA was isolated from Mexican deer mice (Peromyscus mexicanus) captured near the site of a 1967 epidemic of ... During a study to extend our knowledge of the host range and genetic diversity of arenaviruses in Great Britain, 66 of 1,147 ... An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents... ...
5.) World Health Organization. Ebola virus disease outbreak: Ebola is no longer a public health emergency of international ... such as arenaviruses, bunyaviruses, filoviruses, orthomyxoviruses, and paramyxoviruses. These viruses share certain biologic, ... The safe operation of high-level biocontainment laboratories throughout the world is of highest importance. These laboratories ...
The Lens serves almost all the patents and scholarly work in the world as a free, open and secure digital public good, with ... arenaviruses, bornaviruses, bunyviruses, orthomyxoviruses (e.g., influenza virus), and rhabdoviruses that are negative-stranded ...
Arenaviruses. Arenavirus is a genus of primitive viruses, at least eight species of which are known to cause serious diseases ... They are divided into two groups called Old World and New World depending on where they were discovered but they also ... The most well-known species is B. Quintana which was the cause of trench fever during the First World War and spread by the ... http://www.who.int/campaigns/world-health-day/2014/global-brief/en/ ...
Dry eye disease is a common condition that affects millions of people world wide. Adherence to and beliefs in lipid-lowering ... Currently, no FDA-licensed vaccines are available to combat arenavirus infections and antiarenaviral therapy is limited to the ...
NO download Craft beer world : a guide to over 350 of the finest beers known to man 2013 by VEGF can function all through the ... The download segmented negative strand viruses arenaviruses bunyaviruses and of the great effect cell-cell into a endoplasmic 1 ... As the staggered functions of functions become the download segmented negative strand viruses arenaviruses bunyaviruses and to ... ROBO2 together is download segmented negative strand viruses arenaviruses bunyaviruses and orthomyxoviruses differentiation ...
In the present cefaclor dose for uti prophylaxis bactrim study, we report that the Z protein of the Old World arenavirus Lassa ...
Back cover: Within a remarkably short period of time it became clear that TT viruses are widely spread globally, infect a large proportion of all human populations studied thus far and represent an extremely heterogeneous group of viruses, now labelled as Anelloviruses. TT virus-like infections have also been noted in various animal species. The classification of this virus group turns out to be difficult, their DNA contains between 2200 and 3800 nucleotides, related so-called TT-mini-viruses and a substantial proportion of intragenomic recombinants further complicate attempts to combine these viruses into a unifying phylogenetic concept. Although studied in many laboratories, the medically most interesting question of their possible pathogenic role in humans remains unanswered until today. It is not unreasonable to suspect that persistence of at least some specific TT virus genotypes may result in some infected individuals in a definable pathogenicity. We believe that this volume provides first ...
These viruses are ubiquitous in fresh water from all over the world. The chlorella viruses have genomes as large as 370 kb that ... hemorrhagic bunya and arenaviruses) to understand the basic mechanisms of the genetic expression of this group of viruses. ...
... of the complete virus S and L RNA segment sequences identified the virus as a member of the New World Clade B arenaviruses, ... and identified as an arenavirus by IFA staining with a rabbit polyvalent antiserum raised against South American arenaviruses ... and identified as an arenavirus by IFA staining with a rabbit polyvalent antiserum raised against South American arenaviruses ... and identified as an arenavirus by IFA staining with a rabbit polyvalent antiserum raised against South American arenaviruses ...
Our shipping charges are regionally defined, in the UK, Europe (EEC), North America and the Rest of the World as detailed below ... Arenavirus Receptors * Coronavirus Receptors * Filovirus Receptors * Flavivirus Receptors * Herpesvirus Receptors * ...
Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized ...
... arenaviruses, and New World hantaviruses. Am. J. Trop. Med. Hyg. 82, 954-960 (2010). doi:10.4269/ajtmh.2010.09-0636 pmid: ... NIH grant 1U01HG007480-01 and the World Bank (C.H.), European Union grant FP7/2007-2013 278433-PREDEMICS and European Research ...
Ahead of Print -Arenavirus Diversity and Phylogeog.... *Ahead of Print -Deletion Variants of Middle East R... ... Announcement: World Birth Defects Day - March 3, 2.... *Notes from the Field: Verona Integron-Encoded Meta... ...
World J Gastroenterol. 2015 Nov 28;21(44):12576-85.. Cell Assay [2] The human GIST cell lines GK1C and GK3C, and the Imatinib- ...
Online access to the Oxford Textbook of Medicine in low and middle income countries is available through the World Health ... 7.5.17 Arenaviruses. *7.5.18 Filoviruses. *7.5.19 Papillomaviruses and polyomaviruses. *7.5.20 Parvovirus B19 ...
Online access to the Oxford Textbook of Medicine in low and middle income countries is available through the World Health ... 7.5.17 Arenaviruses. *7.5.18 Filoviruses. *7.5.19 Papillomaviruses and polyomaviruses. *7.5.20 Parvovirus B19 ...
Arenaviruses, New World , Viral Vaccines ... INTRODUCTION: Arenavirus hemorrhagic fever is a severe emerging ... Arenavirus/immunology , Enzyme-Linked Immunosorbent Assay/standards , Junin virus/immunology , Arenavirus/genetics , Brazil , ... INTRODUÇÃO: A febre hemorrágica por Arenavirus é uma severa doença emergente. MÉTODOS: Considerando que os níveis de anticorpos ... METHODS: Considering that the levels of antibodies against arenavirus in the Brazilian population are completely unknown, we ...
  • Results of this pilot study suggest that the Pirital virus-hamster model is a very promising new small animal model for studying the pathogenesis of arenavirus infections, particularly, the mechanism of direct virus-induced hepatic injury. (ajtmh.org)
  • To evaluate the efficacy of chemical inactivation procedures for specimen removal, we used the US prime select agent and Tier-1 pathogen (4) Zaire ebolavirus (EBOV) as a surrogate model for enveloped high-level containment viruses with single-strand, negative-sense RNA genomes, such as arenaviruses, bunyaviruses, filoviruses, orthomyxoviruses, and paramyxoviruses. (thefreelibrary.com)
  • Background: Dengue viruses have been identified as the most important arboviral pathogen in the world. (bvsalud.org)
  • In this review, we draw upon recently elucidated paramyxovirus-, arenavirus-, and poxvirus-host protein complex crystal structures to reveal both the capacity of viruses to appropriate one component of a physiological protein-protein binding event (often modifying it to out-compete the host-protein), and the ability to utilize novel binding sites on host cell surface receptors. (cyberleninka.org)
  • Mosquito-borne viruses are emerging or re-emerging globally, afflicting millions of people around the world. (bvsalud.org)
  • Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus, a member of the arenavirus family of viruses. (who.int)
  • The cotton rat ( Sigmodon hispidus ) is a New World rodent species that has a long-standing history as an experimental animal model due to its unique susceptibility to human viruses. (biomedcentral.com)
  • All rats were seronegative and virus-negative for several rodentborne pathogens enzootic in South Florida, includ- ing hantaviruses, arenaviruses, eastern equine encephalitis virus, and EVEV. (cdc.gov)
  • METHODS: Considering that the levels of antibodies against arenavirus in the Brazilian population are completely unknown, we have standardized an ELISA test for detecting IgG antibodies using a recombinant nucleoprotein from the Junin virus as the antigen. (bvsalud.org)
  • Immunohistochemical analysis revealed arenavirus antigen in the liver and kidney transplants in the recipients. (notifylibrary.org)
  • WHO is also working closely with the Food and Agriculture Organization of the United Nations (FAO) and the World Organisation for Animal Health (OIE) in a 'One Health' approach to promote best practices to avoid the emergence and spread of antibacterial resistance, including optimal use of antibiotics in both humans and animals. (who.int)
  • The data and information is not guaranteed to be complete or to be fully up to date at any particular moment and it reflects the knowledge and views of the experts participating, not those of the World Health Organisation or the Italian National Transplant Centre. (notifylibrary.org)
  • Rio Grande, fifth longest river of North America, and the 20th longest in the world, forming the border between the U.S. state of Texas and Mexico. (britannica.com)
  • CONCLUSIONS: These results show the population studied may present exposure to arenavirus infection. (bvsalud.org)
  • We report here the isolation of an arenavirus from a common marmoset (Callithrix jacchus) with CH by using in vitro cultures of marmoset hepatocytes and Vero-E6 cells. (elsevier.com)
  • The use of this method during an outbreak of disease facilitated the identification of a new arenavirus transmitted through solid-organ transplantation. (notifylibrary.org)
  • The only standard vaccine to consider for Andorra would be tetanus in line with many other developed countries of the world. (tmb.ie)
  • New clinical scenarios demonstrate key applications of microbiology in the real world. (b-ok.org)
  • The safe operation of high-level biocontainment laboratories throughout the world is of highest importance. (thefreelibrary.com)