Arenaviruses new world. Medical search

One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. It includes JUNIN VIRUS; PICHINDE VIRUS; Amapari virus, and Machupo virus among others. They are the cause of human hemorrhagic fevers mostly in Central and South America.

One of two groups of viruses in the ARENAVIRUS genus and considered part of the Old World complex. It includes LASSA VIRUS and LYMPHOCYTIC CHORIOMENINGITIS VIRUS, although the latter has worldwide distribution now.

The only genus in the family ARENAVIRIDAE. It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution.

Virus diseases caused by the ARENAVIRIDAE.

A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.

A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). Infection in rodents is persistent and silent. Vertical transmission is through milk-, saliva-, or urine-borne routes. Horizontal transmission to humans, monkeys, and other animals is important.

A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.

An infraorder of New World monkeys, comprised of the families AOTIDAE; ATELIDAE; CEBIDAE; and PITHECIIDAE. They are found exclusively in the Americas.

A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. The disease is characterized by congestion, edema, generalized lymphadenopathy and hemorrhagic necrosis and is sometimes fatal.

Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).

A family of New World monkeys in the infraorder PLATYRRHINI, consisting of nine subfamilies: ALOUATTINAE; AOTINAE; Atelinae; Callicebinae; CALLIMICONINAE; CALLITRICHINAE; CEBINAE; Pithecinae; and SAIMIRINAE. They inhabit the forests of South and Central America, comprising the largest family of South American monkeys.

A species of ARENAVIRUS, one of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing a fatal infection in the cricetine rodent Oryzomys albigularis. Asymptomatic laboratory infection in humans has been reported.

Biological activities of viruses and their interactions with the cells they infect.

The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.

The family of Old World monkeys and baboons consisting of two subfamilies: CERCOPITHECINAE and COLOBINAE. They are found in Africa and part of Asia.

Dystrophin-associated proteins that play role in the formation of a transmembrane link between laminin-2 and DYSTROPHIN. Both the alpha and the beta subtypes of dystroglycan originate via POST-TRANSLATIONAL PROTEIN PROCESSING of a single precursor protein.

The relationships of groups of organisms as reflected by their genetic makeup.

A group of iron-binding proteins that tightly bind two ferrate ions along with two carbonate ions. They are found in the bodily fluids of vertebrates where they act as transport and storage molecules for iron.

A genus of the subfamily CALLITRICHINAE occurring in forests of Brazil and Bolivia and containing seventeen species.

A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.

An acute febrile human disease caused by the LASSA VIRUS.

The general name for NORTH AMERICA; CENTRAL AMERICA; and SOUTH AMERICA unspecified or combined.

A genus in the subfamily CALLITRICHINAE consisting of 12 species and found in Panama as well as South America. Species seen most frequently in the literature are S. oedipus (cotton-top marmoset), S. nigricollis, and S. fusicollis.

A genus of the family CEBIDAE consisting of four species: S. boliviensis, S. orstedii (red-backed squirrel monkey), S. sciureus (common squirrel monkey), and S. ustus. They inhabit tropical rain forests in Central and South America. S. sciureus is used extensively in research studies.

The entering of cells by viruses following VIRUS ATTACHMENT. This is achieved by ENDOCYTOSIS, by direct MEMBRANE FUSION of the viral membrane with the CELL MEMBRANE, or by translocation of the whole virus across the cell membrane.

A family of the New World monkeys inhabiting the forests of South and Central America. There is a single genus and several species occurring in this family, including AOTUS TRIVIRGATUS (Northern night monkeys).

A family of snakes comprising the boas, anacondas, and pythons. They occupy a variety of habitats through the tropics and subtropics and are arboreal, aquatic or fossorial (burrowing). Some are oviparous, others ovoviviparous. Contrary to popular opinion, they do not crush the bones of their victims: their coils exert enough pressure to stop a prey's breathing, thus suffocating it. There are five subfamilies: Boinae, Bolyerinae, Erycinae, Pythoninae, and Tropidophiinae. (Goin, Goin, and Zug, Introduction to Herpetology, 3d ed, p315-320)

Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response.

A genus of the family CEBIDAE, subfamily CEBINAE, consisting of four species which are divided into two groups, the tufted and untufted. C. apella has tufts of hair over the eyes and sides of the head. The remaining species are without tufts - C. capucinus, C. nigrivultatus, and C. albifrons. Cebus inhabits the forests of Central and South America.

A CELL LINE derived from the kidney of the African green (vervet) monkey, (CERCOPITHECUS AETHIOPS) used primarily in virus replication studies and plaque assays.

A species of CERCOPITHECUS containing three subspecies: C. tantalus, C. pygerythrus, and C. sabeus. They are found in the forests and savannah of Africa. The African green monkey (C. pygerythrus) is the natural host of SIMIAN IMMUNODEFICIENCY VIRUS and is used in AIDS research.

Limbless REPTILES of the suborder Serpentes.

Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

A mammalian order which consists of 29 families and many genera.

Proteins conjugated with nucleic acids.

Membrane glycoproteins found in high concentrations on iron-utilizing cells. They specifically bind iron-bearing transferrin, are endocytosed with its ligand and then returned to the cell surface where transferrin without its iron is released.

Proteins found in any species of virus.

A genus of the subfamily ALOUATTINAE, family ATELIDAE, inhabiting the forests of Central and South America. Howlers travel in groups and define their territories by howling accompanied by vigorously shaking and breaking branches.

The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.

The binding of virus particles to receptors on the host cell surface. For enveloped viruses, the virion ligand is usually a surface glycoprotein as is the cellular receptor. For non-enveloped viruses, the virus CAPSID serves as the ligand.

A genus of the subfamily SIGMODONTINAE consisting of 49 species. Two of these are widely used in medical research. They are P. leucopus, or the white-footed mouse, and P. maniculatus, or the deer mouse.

Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).

A species in the family AOTIDAE, inhabiting the forested regions of Central and South America (from Panama to the Amazon). Vocalizations occur primarily at night when they are active, thus they are also known as Northern night monkeys.

Ribonucleic acid that makes up the genetic material of viruses.

An area showing altered staining behavior in the nucleus or cytoplasm of a virus-infected cell. Some inclusion bodies represent "virus factories" in which viral nucleic acid or protein is being synthesized; others are merely artifacts of fixation and staining. One example, Negri bodies, are found in the cytoplasm or processes of nerve cells in animals that have died from rabies.

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

A subfamily in the family ATELIDAE, comprising three genera: woolly monkeys (Lagothrix), spider monkeys (Ateles), and woolly spider monkeys (Brachyteles).

Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.

The period of history before 500 of the common era.

A tomographic technique for obtaining 3-dimensional images with transmission electron microscopy.

The interactions between a host and a pathogen, usually resulting in disease.

Proteolytic enzymes that are involved in the conversion of protein precursors such as peptide prohormones into PEPTIDE HORMONES. Some are ENDOPEPTIDASES, some are EXOPEPTIDASES.

A suborder of PRIMATES consisting of the following five families: CHEIROGALEIDAE; Daubentoniidae; Indriidae; LEMURIDAE; and LORISIDAE.

A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.

A specialized agency of the United Nations designed as a coordinating authority on international health work; its aim is to promote the attainment of the highest possible level of health by all peoples.

Suspensions of attenuated or killed viruses administered for the prevention or treatment of infectious viral disease.

Ruminant mammals of South America. They are related to camels.

Established cell cultures that have the potential to propagate indefinitely.

Release of a virus from the host cell following VIRUS ASSEMBLY and maturation. Egress can occur by host cell lysis, EXOCYTOSIS, or budding through the plasma membrane.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly.

The concept pertaining to the health status of inhabitants of the world.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

The complete genetic complement contained in a DNA or RNA molecule in a virus.

Viruses whose genetic material is RNA.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

A subfamily in the family CEBIDAE that consists of four genera: CALLITHRIX (marmosets), CALLIMICO (Goeldi's monkey), LEONTOPITHECUS (lion tamarins), and SAGUINUS (long-tusked tamarins). The members of this family inhabit the tropical forests of South and Central America.

A family of New World monkeys in the infraorder PLATYRRHINI consisting of two subfamilies: Callicebinae and Pitheciinae.

Time period from 1401 through 1500 of the common era.

Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.

The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.

A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)

Individual members of South American ethnic groups with historic ancestral origins in Asia.

Diseases of Old World and New World monkeys. This term includes diseases of baboons but not of chimpanzees or gorillas (= APE DISEASES).

A disease characterized by the chronic, progressive spread of lesions from New World cutaneous leishmaniasis caused by species of the L. braziliensis complex to the nasal, pharyngeal, and buccal mucosa some time after the appearance of the initial cutaneous lesion. Nasal obstruction and epistaxis are frequent presenting symptoms.

Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).

A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi.

The process of intracellular viral multiplication, consisting of the synthesis of PROTEINS; NUCLEIC ACIDS; and sometimes LIPIDS, and their assembly into a new infectious particle.

A region, north-central Asia, largely in Russia. It extends from the Ural Mountains to the Pacific Ocean and from the Arctic Ocean to central Kazakhstan and the borders of China and Mongolia.

A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. Infection is found primarily in rodents and humans. Transmission does not appear to involve arthropods. HANTAAN VIRUS is the type species.

Process of growing viruses in live animals, plants, or cultured cells.

The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)

Time period from 1501 through 1600 of the common era.

The largest of the continents. It was known to the Romans more specifically as what we know today as Asia Minor. The name comes from at least two possible sources: from the Assyrian asu (to rise) or from the Sanskrit usa (dawn), both with reference to its being the land of the rising sun, i.e., eastern as opposed to Europe, to the west. (From Webster's New Geographical Dictionary, 1988, p82 & Room, Brewer's Dictionary of Names, 1992, p34)

The infective system of a virus, composed of the viral genome, a protein core, and a protein coat called a capsid, which may be naked or enclosed in a lipoprotein envelope called the peplos.

Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.

The wood fern plant family of the order Polypodiales, class Filicopsida, division Pteridophyta.

A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).

Immunoglobulins produced in response to VIRAL ANTIGENS.

Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.

Electron microscopy involving rapid freezing of the samples. The imaging of frozen-hydrated molecules and organelles permits the best possible resolution closest to the living state, free of chemical fixatives or stains.

Genotypic differences observed among individuals in a population.

Substances elaborated by viruses that have antigenic activity.

A monocot plant family of the Liliopsida class. It is classified by some in the Liliales order and some in the Asparagales order.

An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.

A species of SPUMAVIRUS causing non-pathogenic infections in chimpanzees and humans.

A genus of the family Lemuridae consisting of five species: L. catta (ring-tailed lemur), L. fulvus, L. macaco (acoumba or black lemur), L. mongoz (mongoose lemur), and L. variegatus (white lemur). Most members of this genus occur in forested areas on Madagascar and the Comoro Islands.

The scientific study of past societies through artifacts, fossils, etc.

A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)

Global conflict involving countries of Europe, Africa, Asia, and North America that occurred between 1939 and 1945.

Individual members of Central American ethnic groups with ancient historic ancestral origins in Asia. Mexican Indians are not included.

Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.

A species of orangutan, family HOMINIDAE, found in the forests on the island of Borneo.

Experimental infection of the cane mouse Zygodontomys brevicauda (family Muridae) with guanarito virus (Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. (1/127)

Chronic infections in specific rodents appear to be crucial to the long-term persistence of arenaviruses in nature. The cane mouse, Zygodontomys brevicauda, is a natural host of Guanarito virus (family Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. The purpose of this study was to elucidate the natural history of Guanarito virus infection in Z. brevicauda. Thirty-nine laboratory-reared cane mice each were inoculated subcutaneously with 3.0 log10 plaque-forming units of the Guanarito virus prototype strain INH-95551. No lethality was associated with infection in any animal, regardless of age at inoculation. The 13 newborn, 14 weanling, and 8 of the 12 adult animals developed chronic viremic infections characterized by persistent shedding of infectious virus in oropharyngeal secretions and urine. These findings indicate that Guanarito virus infection in Z. brevicauda can be chronic and thus support the concept that this rodent species is the natural reservoir of Guanarito virus. (+info)

Guanarito virus (Arenaviridae) isolates from endemic and outlying localities in Venezuela: sequence comparisons among and within strains isolated from Venezuelan hemorrhagic fever patients and rodents. (2/127)

Despite intensive surveillance, Venezuelan hemorrhagic fever (VHF), caused by Guanarito (GTO) virus, has been detected in only a small region of western Venezuela. To determine whether VHF is associated with a particular regional GTO virus strain(s), 29 isolates from rodents and humans throughout the surrounding regions were analyzed by partial sequencing of the nucleocapsid protein gene. Phylogenetic trees delineated nine distinct GTO genotypes that differ by 4-17% in nucleotides and up to 9% in amino acid sequences; most appeared to be restricted to discrete geographic regions, although a few genotypes were isolated in several locations. Each genotype included at least one strain recovered from a rodent, but only two genotypes were isolated from VHF cases. The presence outside of the endemic/epidemic region of two genotypes isolated also from VHF cases suggests that human pathogenic viruses occur outside of the endemic zone, but do not frequently infect people and/or cause apparent disease there. VHF does not appear to be associated with a GTO virus genotype that is restricted to a certain rodent species. When quasispecies diversity was examined, rodent isolates had higher sequence variation than human isolates. One rodent isolate included a mixture of two phylogenetically distinct genotypes, suggesting a dual infection. (+info)

Homologous and heterologous glycoproteins induce protection against Junin virus challenge in guinea pigs. (3/127)

Tacaribe virus (TACV) is an arenavirus that is genetically and antigenically closely related to Junin virus (JUNV), the aetiological agent of Argentine haemorrhagic fever (AHF). It is well established that TACV protects experimental animals fully against an otherwise lethal challenge with JUNV. To gain information on the nature of the antigens involved in cross-protection, recombinant vaccinia viruses were constructed that express the glycoprotein precursor (VV-GTac) or the nucleocapsid protein (VV-N) of TACV. TACV proteins expressed by vaccinia virus were indistinguishable from authentic virus proteins by gel electrophoresis. Guinea pigs inoculated with VV-GTac or VV-N elicited antibodies that immunoprecipitated authentic TACV proteins. Antibodies generated by VV-GTac neutralized TACV infectivity. Levels of antibodies after priming and boosting with recombinant vaccinia virus were comparable to those elicited in TACV infection. To evaluate the ability of recombinant vaccinia virus to protect against experimental AHF, guinea pigs were challenged with lethal doses of JUNV. Fifty per cent of the animals immunized with VV-GTac survived, whereas all animals inoculated with VV-N or vaccinia virus died. Having established that the heterologous glycoprotein protects against JUNV challenge, a recombinant vaccinia virus was constructed that expresses JUNV glycoprotein precursor (VV-GJun). The size and reactivity to monoclonal antibodies of the vaccinia virus-expressed and authentic JUNV glycoproteins were indistinguishable. Seventy-two per cent of the animals inoculated with two doses of VV-GJun survived lethal JUNV challenge. Protection with either VV-GJun or VV-GTac occurred in the presence of low or undetectable levels of neutralizing antibodies to JUNV. (+info)

The Whitewater Arroyo virus: natural evidence for genetic recombination among Tacaribe serocomplex viruses (family Arenaviridae). (4/127)

The Tacaribe serocomplex (family Arenaviridae) comprises three phylogenetic lineages, designated A, B, and C. The sequence of a 3278-nt fragment of the small genomic segment of the Whitewater Arroyo (WWA) virus was determined to extend our knowledge on the phylogenetic relationship of this newly discovered North American Tacaribe complex virus to other arenaviruses. Independent analyses of full-length nucleoprotein (N) and glycoprotein precursor (GPC) amino acid sequences indicated that the WWA virus N and GPC genes are descended from a lineage A virus and lineage B virus, respectively. The different phylogenetic histories of the N and GPC genes indicate that the WWA virus genome is a product of recombination between two Tacaribe complex viruses. (+info)

Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral hemorrhagic fever. (5/127)

Adult Syrian golden hamsters inoculated intraperitoneally with Pirital virus, a recently discovered member of the Tacaribe complex of New World arenaviruses, developed a progressively severe, fatal illness with many of the pathologic features observed in fatal human cases of Lassa fever and other arenaviral hemorrhagic fevers. Most of the animals became moribund by Day 5 and were dead by Day 7 after inoculation. The most consistent histopathologic changes included interstitial pneumonitis, splenic lymphoid depletion and necrosis, and multifocal hepatic necrosis without significant inflammatory cell infiltration. The liver changes ranged from single cell death by apoptosis to coagulative necrosis of clusters of hepatocytes. Immunohistochemical studies of the liver demonstrated the presence and accumulation ot Pirital virus antigen within hepatocytes as well as Kupffer cells. An in situ terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) assay showed progressively increasing apoptotic activity in the liver of infected hamsters. A human hepatoblastoma cell line (Hep G2/C3A) inoculated with Pirital virus also developed progressive cell destruction and accumulation of viral antigen, as demonstrated by immunofluorescence. Results of this pilot study suggest that the Pirital virus-hamster model is a very promising new small animal model for studying the pathogenesis of arenavirus infections, particularly, the mechanism of direct virus-induced hepatic injury. It may also be useful for testingantiviral agents for treatment of arenaviral hemorrhagic fevers. (+info)

Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors. (6/127)

Here we provide the first report of protection against a vaginal challenge with a highly virulent simian immunodeficiency virus (SIV) by using a vaccine vector. New poliovirus vectors based on Sabin 1 and 2 vaccine strain viruses were constructed, and these vectors were used to generate a series of new viruses containing SIV gag, pol, env, nef, and tat in overlapping fragments. Two cocktails of 20 transgenic polioviruses (SabRV1-SIV and SabRV2-SIV) were inoculated into seven cynomolgus macaques. All monkeys produced substantial anti-SIV serum and mucosal antibody responses. SIV-specific cytotoxic T-lymphocyte responses were detected in three of seven monkeys after vaccination. All 7 vaccinated macaques, as well as 12 control macaques, were challenged vaginally with pathogenic SIVmac251. Strikingly, four of the seven vaccinated animals exhibited substantial protection against the vaginal SIV challenge. All 12 control monkeys became SIV positive. In two of the seven SabRV-SIV-vaccinated monkeys we found no virological evidence of infection following challenge, indicating that these two monkeys were completely protected. Two additional SabRV-SIV-vaccinated monkeys exhibited a pronounced reduction in postacute viremia to <10(3) copies/ml, suggesting that the vaccine elicited an effective cellular immune response. Three of six control animals developed clinical AIDS by 48 weeks postchallenge. In contrast, all seven vaccinated monkeys remained healthy as judged by all clinical parameters. These results demonstrate the efficacy of SabRV as a potential human vaccine vector, and they show that the use of a vaccine vector cocktail expressing an array of defined antigenic sequences can be an effective vaccination strategy in an outbred population. (+info)

Transcription and RNA replication of tacaribe virus genome and antigenome analogs require N and L proteins: Z protein is an inhibitor of these processes. (7/127)

Tacaribe virus (TV), the prototype of the New World group of arenaviruses, comprises a single phylogenetic lineage together with four South American pathogenic producers of hemorrhagic disease. The TV genome consists of two single-stranded RNA segments called S and L. A reconstituted transcription-replication system based on plasmid-supplied TV-like RNAs and TV proteins was established. Plasmid expression was driven by T7 RNA polymerase supplied by a recombinant vaccinia virus. Plasmids were constructed to produce TV S segment analogs containing the negative-sense copy of chloramphenicol acetyltransferase (CAT) flanked at the 5' and 3' termini by sequences corresponding to those of the 5' and 3' noncoding regions of the S genome (minigenome) or the S antigenome (miniantigenome). In cells expressing N and L proteins, input minigenome or miniantigenome produced, respectively, encapsidated miniantigenome or minigenome which in turn produced progeny minigenome or progeny miniantigenome. Both minigenome and miniantigenome in the presence of N and L mediated transcription, which was analyzed as CAT expression. Coexpression of the small RING finger Z (p11) protein was highly inhibitory to both transcription and replication mediated by the minigenome or the miniantigenome. The effect depended on synthesis of Z protein rather than on plasmid or the RNA and was not ascribed to decreased amounts of plasmid-supplied template or proteins (N or L). N and L proteins were sufficient to support full-cycle RNA replication of a plasmid-supplied S genome analog in which CAT replaced the N gene. Replication of this RNA was also inhibited by Z expression. (+info)

New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor. (8/127)

Alpha-dystroglycan (alpha-DG) has been identified as a major receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa virus, two Old World arenaviruses. The situation with New World arenaviruses is less clear: previous studies demonstrated that Oliveros virus also exhibited high-affinity binding to alpha-DG but that Guanarito virus did not. To extend these initial studies, several additional Old and New World arenaviruses were screened for entry into mouse embryonic stem cells possessing or lacking alpha-DG. In addition, representative viruses were further analyzed for direct binding to alpha-DG by means of a virus overlay protein blot assay technique. These studies indicate that Old World arenaviruses use alpha-DG as a major receptor, whereas, of the New World arenaviruses, only clade C viruses (i.e., Oliveros and Latino viruses) use alpha-DG as a major receptor. New World clade A and B arenaviruses, which include the highly pathogenic Machupo, Guanarito, Junin, and Sabia viruses, appear to use a different receptor or coreceptor for binding. Previous studies with LCMV have suggested the need for a small aliphatic amino acid at LCMV GP1 glycoprotein amino acid position 260 to allow high-affinity binding to alpha-DG. As reported herein, this requirement appears to be broadly applicable to the arenaviruses as determined by more extensive analysis of alpha-DG receptor usage and GP1 sequences of Old and New World arenaviruses. In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG binding possess a bulky aromatic amino acid (tyrosine or phenylalanine) at this position. (+info)

It is a member of Clade A of the Tacaribe (or "New World") serocomplex of the family Arenaviridae. Laboratory workers infected ... Zuckerman 2014, p. 10 "Viral Hemorrhagic Fevers Caused by Arenaviruses" (PDF). The Center for Food Security and Public Health. ... Zuckerman, Ben (2014). Howard, C R (ed.). Arenaviruses. Elsevier. p. 7. ISBN 9780080877372. ... an arenavirus with a mammalian host. It was first found in semiaquatic rodents of the genus Oryzomys in tropical forest in the ...

https://en.wikipedia.org/wiki/Flexal_mammarenavirus

The New World and Old World species diverged less than 45,000 years ago. The New World species evolved between 41,400 and 3,300 ... virus is the only arenavirus to exist in both areas but is classified as an Old World virus. Old and New World area viruses ... termini of the virion RNA species of New World and Old World arenaviruses". Virology. 121 (1): 200-3. doi:10.1016/0042-6822(82) ... The Old World Mammarenaviruses originated ~23.1-1.88 thousand years ago, most likely in Southern Africa while the New World ...

https://en.wikipedia.org/wiki/Arenavirus

... all three being New World arenaviruses. The virus is named after Bear Canyon, the area it was originally discovered in. Cajimat ... An Arenavirus Naturally Associated with the California Mouse (Peromyscus californicus)". Emerging Infectious Diseases. 8 (7): ... "Principal host relationships and evolutionary history of the North American arenaviruses". Virology. 367 (2): 235-243. doi: ...

https://en.wikipedia.org/wiki/Bear_Canyon_mammarenavirus

"Phylogeny and evolution of old world arenaviruses". Virology. 350 (2): 251-7. doi:10.1016/j.virol.2006.01.026. PMID 16494913. ... Gonzalez JP, Sanchez A, Rico-Hesse R (July 1995). "Molecular phylogeny of Guanarito virus, an emerging arenavirus affecting ... "One Health Initiative - One World One Medicine One Health". www.onehealthinitiative.com. Retrieved 2018-06-29. Ezama A, ... Arenavirus, Hantavirus, Crimean Congo Hemorrhagic virus and others. In the late 90s he began working as a professor of ...

https://en.wikipedia.org/wiki/Jean-Paul_Gonzalez

They suggested that scholars consider New World arenaviruses and the role these pathogens may have played in colonial disease ... would have increased the presence of New World rats and mice. These animals may have carried arenaviruses capable of causing ... Somolinos d'Ardois believed cocoliztli was not the result of any known Old World pathogen but possibly a virus of New World ... Given that many Old World pathogens may have caused the cocoliztli outbreak, it is significant that all but two of the most ...

https://en.wikipedia.org/wiki/Cocoliztli_epidemics

... the Old World arenaviruses, and the New World arenaviruses. Old World arenaviruses include lymphocytic choriomeningitis virus ... New world arena viruses are further broken down into three clades, A, B, and C. The Guanarito arena virus belongs to clade B ... February 2008). "Receptor determinants of zoonotic transmission of New World hemorrhagic fever arenaviruses". Proc. Natl. Acad ... Arenaviruses causing hemorrhagic fevers, along with a genus of virus called filoviruses, were categorized in Category A; these ...

https://en.wikipedia.org/wiki/Venezuelan_hemorrhagic_fever

Alpha-dystroglycan is also used as a receptor by viruses of the New World clade C arenaviruses (Oliveros and Latino viruses). ... The life cycle of Lassa mammarenavirus is similar to the Old World arenaviruses. Lassa mammarenavirus enters the cell by the ... It shares this receptor with the prototypic Old World arenavirus lymphocytic choriomeningitis virus. Receptor recognition ... the New World arenaviruses of clades A and B, which include the important viruses Machupo, Guanarito, Junin, and Sabia in ...

https://en.wikipedia.org/wiki/Lassa_mammarenavirus

Picornaviruses have been identified from a diverse array of bat species around the world. Arenaviruses are mainly associated ... The first arenavirus identified in bats was Tacaribe mammarenavirus, which was isolated from Jamaican fruit bats and the great ... The hepadnavirus found in the tent-making bat, which is a New World species, was the closest relative of human hepadnoviruses. ... "Ebola virus disease". World Health Organization. 10 February 2020. Retrieved 13 April 2020. "What is Ebola Virus Disease?". ...

https://en.wikipedia.org/wiki/Bat_virome

"Fatal Illnesses Associated With a New World Arenavirus --- California, 1999--2000". MMWR Weekly. Fulhorst, Charles; Charrel, ... Arenavirus-specific RNA was detected in each patient using RT-PCR. The nucleotide sequence of the patients were essentially ... Like other arenaviruses, WWAV appears to be transmitted through rodents. Therefore, direct contact with rodents, their feces, ... in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ...

https://en.wikipedia.org/wiki/Whitewater_Arroyo_mammarenavirus

Specifically it is an old world arenavirus, which is enveloped, single-stranded, and bi-segmented RNA. This virus has both a ... World Health Organization. Archived from the original on 5 June 2015. Retrieved 26 May 2015. Dongo, A. E.; Kesieme, E. B.; ... "Lassa fever". World Health Organization. Retrieved 11 September 2017. McCormick, J. B.; King, I. J.; Webb, P. A.; Scribner, C. ... "Lassa Fever - Nigeria". World Health Organization. 1 March 2018. Archived from the original on 1 March 2018. Edward-Ekpu, ...

https://en.wikipedia.org/wiki/Lassa_fever

It is of the "Old World" Arenavirus lineage and is closely related to Lassa mammarenavirus, sharing 75% of its amino acid ... Wulff H, McIntosh BM, Hamner DB, Johnson KM (1977). "Isolation of an arenavirus closely related to Lassa virus from Mastomys ... Johnson KM, Taylor P, Elliott LH, Tomori O (November 1981). "Recovery of a Lassa-related arenavirus in Zimbabwe". The American ... Gonzalez JP, Emonet S, de Lamballerie X, Charrel R (2007). Childs JE, Mackenzie JS, Richt JA (eds.). "Arenaviruses". Wildlife ...

https://en.wikipedia.org/wiki/Mopeia_mammarenavirus

"Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections". The ... It is caused by the Junín virus (an arenavirus, closely related to the Machupo virus, causative agent of Bolivian hemorrhagic ...

https://en.wikipedia.org/wiki/Argentine_hemorrhagic_fever

Sequencing of the viral genome has shown that this virus belongs to the Old World arenavirus group. Comparisons with other ... viral genome sequences showed that this virus is equidistant from other Old World and New World arenaviruses. It is distantly ... identified the etiological agent of the outbreak as an Old World arenavirus using molecular and serological tests. Sequencing ... "Discovery of new arenavirus associated with hemorrhagic fever - first identified in nearly four decades". News-Medical.net. ...

https://en.wikipedia.org/wiki/Lujo_mammarenavirus

As receptors for phosphatidylserine, TIM proteins bind many families of viruses [filovirus, flavivirus, New World arenavirus ...

https://en.wikipedia.org/wiki/HAVCR1

... arenavirus MeSH B04.820.057.070.100 - arenaviruses, old world MeSH B04.820.057.070.100.500 - lassa virus MeSH B04.820.057.070. ... arenavirus MeSH B04.909.777.080.070.100 - arenaviruses, old world MeSH B04.909.777.080.070.100.500 - lassa virus MeSH B04.909. ... 100.550 - lymphocytic choriomeningitis virus MeSH B04.820.057.070.800 - arenaviruses, new world MeSH B04.820.057.070.800.450 - ... 777.080.070.100.550 - lymphocytic choriomeningitis virus MeSH B04.909.777.080.070.800 - arenaviruses, new world MeSH B04.909. ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(B04)

... fever on the developing world Monoclonal antibodies to lymphocytic choriomeningitis virus react with pathogenic arenaviruses ... Johnson, K. M.; Taylor, P.; Tomori, O.; Elliott, L. H. (1981-11-01). "Recovery of a Lassa-Related Arenavirus in Zimbabwe". The ... He served as the Regional Virologist for the World Health Organization Africa Region (1994-2004) before he was appointed as the ... "What can Nigeria's Ebola experience teach the world?". The Guardian. October 7, 2014. Retrieved 2019-09-16. Kupferschmidt, Kai ...

https://en.wikipedia.org/wiki/Oyewale_Tomori

The Maiztegui National Human Viral Disease Institute has performed research for the World Health Organization since 1985 and ... currently specializes in four areas: Arenaviruses Arboviruses Hantavirus Production of biological specimens ANLIS (in Spanish) ...

https://en.wikipedia.org/wiki/Maiztegui_National_Human_Viral_Disease_Institute

He is a member of the World Health Organization Collaborating Center for Tropical Diseases. He is also director for biodefense ... His arenavirus research concentrates on the effects of infection on cellular function, particularly those molecular ... Peters, C. J. and Mark Olshaker (1998), Virus Hunter: Thirty Years of Battling Hot Viruses Around the World, Random House. ... of viral diseases including more than 70 publications on Rift Valley fever virus and more than 60 publications on arenaviruses ...

https://en.wikipedia.org/wiki/C._J._Peters

In July 2019, the World Health Organization declared the Congo Ebola outbreak a world health emergency. The length of time ... arenaviruses, and flaviviruses" (PDF). Ministry of Health and Long-Term Care. Archived (PDF) from the original on 15 October ... Health topics: Ebola virus disease - World Health Organization. Videos: Ebola outbreak response - World Health Organization. " ... Urging the world to offer aid to the affected regions, its Director-General said, "Countries affected to date simply do not ...

https://en.wikipedia.org/wiki/Ebola

Guanarito virus New World arenavirus - Junin virus New World arenavirus - Machupo virus New World arenavirus - Sabia virus ... hemorrhagic fever Crimean-Congo hemorrhagic fever virus Ebola virus Lassa virus Lujo virus Marburg virus New World arenavirus ...

https://en.wikipedia.org/wiki/Notifiable_diseases_in_the_United_States

The two RNA segments are denoted Small (S) and Large (L). It belongs to the New World Clade B lineage of mammarenaviruses and ... in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ... Like other members of the Arenavirus family, the specific zoonotic reservoir and primary transmission vector is suspected to be ... a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia". PLOS Pathog. 4 (4): e1000047. doi: ...

https://en.wikipedia.org/wiki/Chapare_mammarenavirus

"Viral Haemorrhagic Fevers". World Health Organization (WHO). United Nations (UN). Archived from the original on August 23, 2004 ... Post-exposure prophylactic (preventive) ribavirin may be effective for some bunyavirus and arenavirus infections. VHF isolation ... 2004). Return of the Black Death: The World's Greatest Serial Killer West Sussex; John Wiley and Sons. ISBN 0-470-09000-6. ... and HFRS due to Old World Hantavirus infection) and can be used only under an experimental protocol as IND approved by the U.S ...

https://en.wikipedia.org/wiki/Viral_hemorrhagic_fever

... is an East African arenavirus infecting the multimammate mouse (Mastomys natalensis). The virus is genetically ... Bull World Health Organ. 52 (4-6): 493-499. PMC 2366657. PMID 182399. (Articles with 'species' microformats, Taxonbars without ... as this has been suggested for other arenaviruses. Günther S, Hoofd G, Charrel R, Röser C, Becker-Ziaja B, Lloyd G, Sabuni C, ... an African arenavirus closely related to Lassa virus, in its natural reservoir host Mastomys natalensis". Sci Rep. 5: 10445. ...

https://en.wikipedia.org/wiki/Morogoro_virus

"Hepatitis B". World Health Organization. Retrieved 5 October 2021."Hepatitis C". World Health Organization. Retrieved 5 October ... Other viruses than can cause hepatitis include: Adenoviruses Arenaviruses: Guanarito virus, Junín virus, Lassa fever virus, ... This occurs primarily in third world countries. Strict personal hygiene and the avoidance of raw and unpeeled foods can help ...

https://en.wikipedia.org/wiki/Viral_hepatitis

Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection. Cell Host ... featuring the top immunologists from around the world. In order to make the talks available longitudinally, the recorded talks ... DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog. 2018 Jul 12;14(7): ... "Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection". Cell Host ...

https://en.wikipedia.org/wiki/Elina_Zúñiga

"A brief history of vaccines and how they changed the world". World Economic Forum. Retrieved 2020-04-30. "Creating a world in ... category A arenavirus) Chlamydia psittaci (category B) Naegleria fowleri (category B) Balamuthia mandrillaris (category B) St. ... CEPI promotes the idea that a proactive approach is required to "create a world in which epidemics are no longer a threat to ... In 2014, the Western African Ebola virus epidemic demonstrated how ill-prepared the world was to handle such an epidemic. In ...

https://en.wikipedia.org/wiki/Emerging_infectious_disease

The mortality rate varies significantly depending on the form, being up to 50% in New World hantaviruses (the Americas), up to ... With the exception of Hantaviruses and Arenaviruses, all viruses in the Bunyavirales order are transmitted by arthropods ( ... 15% in Old World hantaviruses (Asia and Europe), and as little as 0.1% in Puumala virus (mostly Scandinavia). The antibody ...

https://en.wikipedia.org/wiki/Bunyavirales

The island of Vir in Croatia is one of the biggest described endemic places of origin of LCMV in the world, with IFA testing ... The first arenavirus, Lymphocytic choriomeningitis mammarenavirus (LCMV), was isolated in 1933 by Charles Armstrong during a ... World Health Organ. 55 (5): 599-603. PMC 2366689. PMID 338190. ICTVdB-The Universal Virus Database, version 4. [2] Centers for ... LCMV has been shown to cause illness in New World primates such as macaques, marmosets and tamarins. Infections have also been ...

https://en.wikipedia.org/wiki/Lymphocytic_choriomeningitis

First identified in 1958, Argentine hemorrhagic fever is a rodent-borne illness caused by the arenavirus Junin that is endemic ... An online petition was launched on April 27, 2022, asking the World Health Organization to revise its guidelines issued in ... or one-third of the world's population, became infected with this virus. The Spanish influenza pandemic was the first pandemic ...

https://en.wikipedia.org/wiki/Convalescent_plasma

Musser, G.G.; Carleton, M.D. (2005). "Superfamily Muroidea". In Wilson, D.E.; Reeder, D.M (eds.). Mammal Species of the World: ... "Principal host relationships and evolutionary history of the North American arenaviruses". Virology. 367 (2): 235-243. doi: ...

https://en.wikipedia.org/wiki/Big-eared_woodrat

Walt Disney World), multi-purpose arena at Walt Disney World in Florida Arena (1953 film), a 3-D Western starring Gig Young The ... an Australian film production company Arenavirus, an RNA virus that mostly affects rodents Arenas (disambiguation) Larena ( ...

https://en.wikipedia.org/wiki/Arena_(disambiguation)

World Health Organization. Archived from the original on 3 December 2013. Retrieved 2 April 2013. "CDC Media Statement on Newly ... Louis encephalitis, West Nile virus), bunyavirus (La Crosse strain), arenavirus (lymphocytic choriomeningitis virus), reovirus ... World Health Organization. Archived from the original on 3 December 2013. Retrieved 2 April 2013. "Japanese encephalitis". ... encephalitis Cerebritis La Crosse encephalitis Primary amoebic meningoencephalitis Wernicke's encephalopathy World Encephalitis ...

https://en.wikipedia.org/wiki/Encephalitis

There are only two centres in the world authorised by the WHO to keep stocks of smallpox virus: the State Research Center of ... Examples include geminiviruses, which are ssDNA plant viruses and arenaviruses, which are ssRNA viruses of animals. Genome size ... The evidence for an ancestral world of RNA cells and computer analysis of viral and host DNA sequences are giving a better ... The Joint United Nations Programme on HIV/AIDS (UNAIDS) and the World Health Organization (WHO) estimate that AIDS has killed ...

https://en.wikipedia.org/wiki/Virus

ISBN 978-0-387-05199-4. Garrett, Laurie (1994). The Coming Plague: Newly Emerging Diseases in a World Out of Balance. New York ... "Properties of Replication-Competent Vesicular Stomatitis Virus Vectors Expressing Glycoproteins of Filoviruses and Arenaviruses ... This isolation strongly suggests that Old World fruit bats are involved in the natural maintenance of marburgviruses and that ... Marburgviruses are World Health Organization Risk Group 4 Pathogens, requiring Biosafety Level 4-equivalent containment, ...

https://en.wikipedia.org/wiki/Marburg_virus_disease

World Health Organization (2021). Therapeutics and COVID-19: living guideline, 6 July 2021 (Report). World Health Organization ... and one which covered both arenaviruses and coronaviruses. In October 2015, the United States Army Medical Research Institute ... Boseley S (30 June 2020). "US buys up world stock of key Covid-19 drug". The Guardian. Archived from the original on 23 June ... In November 2020, the World Health Organization (WHO) updated its guideline on therapeutics for COVID‑19 to include a ...

https://en.wikipedia.org/wiki/Remdesivir

Prevalence of antibodies to arenaviruses in rodents from the southern and western United States: evidence for an arenavirus ... eds.). Orders and families of Recent mammals of the world. John Wiley and Sons, New York, 686 pp. Carleton, M.D. and Musser, G. ... An arenavirus normally associated with woodrats (Neotoma) has also been found in Florida marsh rice rats. Antibodies against ... 894-1531 in Wilson, D.E. and Reeder, D.M. (eds.). Mammal Species of the World: a taxonomic and geographic reference. 3rd ed. ...

https://en.wikipedia.org/wiki/Marsh_rice_rat

It has particular importance to farmers in certain regions of the world where it infects cattle. This is because its clinical ... "Properties of replication-competent vesicular stomatitis virus vectors expressing glycoproteins of filoviruses and arenaviruses ... Disease card on World Organisation for Animal Health (Articles with short description, Short description matches Wikidata, ...

https://en.wikipedia.org/wiki/Indiana_vesiculovirus

Several arenaviruses cause viral hemorrhagic fever syndromes in Africa and South America. The Old World arenaviruses include ... The South American hemorrhagic fever viruses belong to the Tacaribe complex or New World arenaviruses (e.g., Guanarito, Junin, ... Fatal Illnesses Associated With a New World Arenavirus --- California, 1999--2000. The California Department of Health Services ... Prevalence of antibodies to arenaviruses in rodents from the southern and western United States: evidence for an arenavirus ...

https://www.cdc.gov/mmwr/preview/mmwrhtml/mm4931a1.htm

Old World arenaviruses. New World arenaviruses. Dandedong. Ippy. Kodoko. Mobala. Mopeia. Morogoro. Lassa. LCMV. Lujo. Lemn. ... compared with Old World and 2 New World arenaviruses*. Virus sequence†. ... Nucleotide and amino acid p-distances of 2 arenaviruses in blood of Mus minutoides and Lemniscomys rosalia mice in Morogoro, ... Sympatric Occurrence of 3 Arenaviruses, Tanzania Joëlle Goüy de Bellocq. , Benny Borremans, Abdul Katakweba, Rhodes Makundi, ...

https://wwwnc.cdc.gov/eid/article/16/4/09-1721-t2

Access New World Arenavirus - Guanarito Virus case definitions; uniform criteria used to define a disease for public health ... New World arenavirus - Junin virus 2010 Current New World arenavirus - Machupo virus ... New World arenavirus - Chapare virus 2010 Current New World arenavirus - Guanarito virus ...

https://ndc.services.cdc.gov/?p=126698

Isolation of an arenavirus closely related to Lassa virus from Mastomys natalensis in south-east Africa. ... Bulletin of the World Health Organization, 55 (‎4)‎, 441 - 444. https://extranet.who.int/iris/restricted/handle/10665/261102 ... Wulff, Herta, McIntosh, Bruce M., Hamner, Dale B. & Johnson, Karl M. (‎1977)‎. Isolation of an arenavirus closely related to ...

https://extranet.who.int/iris/restricted/handle/10665/261102?locale-attribute=de&

Arenaviruses (Arenaviridae) (Centers for Disease Control and Prevention) * Crimean-Congo Haemorrhagic Fever (World Health ... VHFs are found around the world. Specific diseases are usually limited to areas where the animals that carry them live. For ...

https://medlineplus.gov/hemorrhagicfevers.html

Categories: Arenaviruses, New World Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...

https://phil.cdc.gov/AdvancedSearchResults.aspx?Search=Arenaviruses,+New+World&parentid=32926&catid=12636

Novel Arenavirus Causes Mystery Illness in Zambia and South Africa. An active, young Zambian safari guide fell ill last month ... Mosquitoes: The Worlds Deadliest Animals. The area surrounding Antananarivo, Madagascar, was not predicted to be a high risk ...

https://blogs.cdc.gov/publichealthmatters/category/vectorborne/page/6/

Relationships among Old World arenaviruses by the neutralization test (log neutralization index determined by reduction of ...

https://wwwn.cdc.gov/Arbocat/VirusDetails.aspx?ID=303&SID=5

World Bank, UNDP, World Health Organization, unpublished data). These areas will have the population density to support ... Coimbra TLM, Nassar ES, Burattini NM, A new arenavirus isolated from a fatal case of haemorrhagic fever in Brazil. Lancet. 1994 ... World Health Organization. Cholera in the Americas. Wkly Epidemiol Rec. 1992;67:33-9.PubMedGoogle Scholar ... Two examples are B virus from primates (45) and hemorrhagic fever with renal syndrome from rodents (46).9. The world trade and ...

https://wwwnc.cdc.gov/eid/article/1/2/95-0201_article

Irwin NR, Bayerlová M, Missa O, Martínková N (2012). Complex patterns of host switching in New World arenaviruses. Molecular ... Michaela Bayerlová: Evolution of protein structure in calcium channels (Mgr.práce), Co-evolution of arenaviruses and their ...

https://www.ivb.cz/osoba/natalia-martinkova/

The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in ...

https://profiles.umassmed.edu/display/123713

The phylogeny of New World (Tacaribe complex) arenaviruses. Virology 219:285-290. [PubMed] [Google Scholar] 11. Cao, W., M. D. ... The prototypic arenavirus lymphocytic choriomeningitis computer virus (LCMV) is one of the most widely used model systems to ... The genome from the prototypic arenavirus lymphocytic choriomeningitis virus (LCMV) includes. The genome from the prototypic ... arenavirus lymphocytic choriomeningitis virus (LCMV) includes two negative-sense, single-strand RNA sections specified S and L ...

http://www.columbiagypsy.net/category/ghs-r1a-receptors/

... and protected mice against challenge with rVACVs expressing either Old or New World arenavirus glycoproteins. In conclusion, ... and protected mice against challenge with rVACVs expressing either Old or New World arenavirus glycoproteins. In conclusion, ... and protected mice against challenge with rVACVs expressing either Old or New World arenavirus glycoproteins. In conclusion, ... and protected mice against challenge with rVACVs expressing either Old or New World arenavirus glycoproteins. In conclusion, ...

https://jhu.pure.elsevier.com/en/publications/a-multivalent-and-cross-protective-vaccine-strategy-against-arena

https://wwwnc-origin.cdc.gov/eid/article/16/4/09-1721-t2

... including New World arenaviruses, lymphocytic choriomeningitis virus, hantaviruses, other Bunyaviridae, Filoviridae, ... arenaviruses and Ebola virus. Reported by: F Mu]oz, MD, C Jarquin, MD, A Gonzalez, MD, J Amador, MD, J de los Reyes, MD, R ...

https://wonder.cdc.gov/wonder/prevguid/m0039519/m0039519.asp

The arenaviruses are divided into two groups: the New World or Tacaribe complex and the Old World or LCM/Lassa complex. Viruses ... How are arenaviruses spread?. The rodent hosts of arenaviruses are chronically infected with the viruses; however, the viruses ... Some Old World arenaviruses appear to be passed from mother rodents to their offspring during pregnancy, and thus remain in the ... Some New World arenaviruses are transmitted among adult rodents, likely via fighting and inflicting bites. Only a portion of ...

https://webarchive.library.unt.edu/eot2008/20090109043409/http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/arena.htm

New World Arenaviruses Medicine & Life Sciences 82% * Viruses Medicine & Life Sciences 42% ... An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents. Analyses of viral ... An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents. Analyses of viral ... An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents. Analyses of viral ...

https://scholars.ttu.edu/en/publications/bear-canyon-virus-an-arenavirus-naturally-associated-with-the-cal

Arenavirus B4.909.777.80.70 Arenaviruses, New World B4.909.777.80.70.800 Arenaviruses, Old World B4.909.777.80.70.100 Aromatase ... World War I I1.880.735.950.250.968 World War II I1.880.735.950.250.984 Xipapillomavirus B4.280.535.950 B4.280.210.655.950 ...

https://decs.bvs.br/P/mnchg2016.txt

Keystone Title: An Analysis of Mechanisms of the Spread for New World Arenaviruses: Biological Mechanisms of Infection, Social ... It is concluded that research efforts regarding human-pathogenic arenaviruses should maintain a balance between understanding ...

https://questu.ca/community-hub/student-features/allison-black-11/

... arenaviruses, and new world hantaviruses. Am J Trop Med Hyg. 2010;82(5):954-60. ... World Health Organization. Ebola haemorrhagic fever in Guinea - update. Geneva: World Health Organization; 2014. Available from ... World Health Organization. Essential medicines and health products: diagnostics. Geneva: World Health Organization; 2018. ... World Health Organization. World malaria report Geneva; 2018. Available from: https://www.who.int/malaria/publications/world- ...

https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05339-2

It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships ... "Arenavirus" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Arenavirus" by people in this website by year, and whether " ... Below are the most recent publications written about "Arenavirus" by people in Profiles. ...

https://profiles.uchicago.edu/profiles/display/30876

In honor of World AIDS Day 2017, Dr Andrew Lever discusses the possibilities and complexities of a cure for HIV in this BMC On ... including arenaviruses like Junin virus. I must admit that I learnt more about Susans back story through an interesting read ... December 1st 2017 is the 30th anniversary of World AIDS Day. This years theme is "Increasing Impact through Transparency, ... We all know Susan as a world renowned retrovirologist with strong interest in both mouse retroviruses and other rodent viruses ...

https://retrovirology.biomedcentral.com/about/news

Arenaviruses, and New World Hantaviruses. American Journal of Tropical Medicine and Hygiene, 82, 954-960. https://doi.org/ ...

https://file.scirp.org/Html/5-2271158_86266.htm

ARENAVIRUSES, OLD WORLD. LEUKEMIA VIRUSES, MURINE. LEUKEMIA VIRUS, MURINE. MAMMARY TUMOR VIRUSES, MOUSE. MAMMARY TUMOR VIRUS, ...

https://decs2013.bvsalud.org/I/rep_i2002.htm

ARENAVIRUSES, OLD WORLD. LEUKEMIA VIRUSES, MURINE. LEUKEMIA VIRUS, MURINE. MAMMARY TUMOR VIRUSES, MOUSE. MAMMARY TUMOR VIRUS, ...

https://decs2014.bvsalud.org/I/rep_i2002.htm

Arenaviruses, New World - Preferred Concept UI. M0010166. Scope note. One of two groups of viruses in the ARENAVIRUS genus and ... Arenaviruses, New World Entry term(s). American Hemorrhagic Fever Virus Hemorrhagic Fever Viruses, American New World ... One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. It includes JUNIN VIRUS; ... New World Arenaviruses. Pirital virus. Pirital viruses. Sabia virus. Tacaribe Complex Viruses. Tacaribe virus. Tacaribe viruses ...

https://decs.bvsalud.org/en/ths/resource/?id=31692&filter=ths_exact_term&q=ARENAVIRUS+DO+NOVO+MUNDO

ARENAVIRUSES, OLD WORLD. LEUKEMIA VIRUSES, MURINE. LEUKEMIA VIRUS, MURINE. MAMMARY TUMOR VIRUSES, MOUSE. MAMMARY TUMOR VIRUS, ...

https://decs2010.bvsalud.org/I/rep_i2002.htm

ARENAVIRUSES, OLD WORLD. LEUKEMIA VIRUSES, MURINE. LEUKEMIA VIRUS, MURINE. MAMMARY TUMOR VIRUSES, MOUSE. MAMMARY TUMOR VIRUS, ...

https://decs2008.bvsalud.org/I/rep_i2002.htm

The Old World arenaviruses include the agents of Lassa fever and lymphocytic choriomeningitis (LCM). (cdc.gov)
The most familiar of the arenaviruses include lymphocytic choriomeningitis virus (LCMV) and hemorrhagic fevers caused by Lassa virus, Machupo virus, and Junin virus. (medscape.com)
This article divides the discussion of these viruses by clinical relevance and manifestations: Old World (Lassa virus, LCMV) and New World (South American hemorrhagic fevers). (medscape.com)
The main hypothesis we tested in the present study was whether it is possible to design a universal vaccine strategy capable of inducing simultaneous HLA-restricted CD8 + T cell responses against 7 pathogenic arenaviruses (including the lymphocytic choriomeningitis, Lassa, Guanarito, Junin, Machupo, Sabia, and Whitewater Arroyo viruses), either through the identification of widely conserved epitopes, or by the identification of a collection of epitopes derived from multiple arenavirus species. (elsevier.com)
The arenaviruses are divided into two groups: the New World or Tacaribe complex and the Old World or LCM/Lassa complex. (unt.edu)
The LCM/Lassa complex viruses are associated with the Old World rats and mice (family Muridae, subfamily Murinae). (unt.edu)
Lassa fever, which is caused by an arenavirus, can affect multiple organs and cause bleeding in late stages. (nhpr.org)
Lassa virus is an Old World arenavirus endemic to West Africa that causes severe hemorrhagic fever. (ox.ac.uk)
Combined, our data provide a structure-based blueprint for understanding how glycans render the glycoprotein spikes of Lassa virus and other Old World arenaviruses immunologically resistant targets. (ox.ac.uk)
Another virus found in Africa that causes hemorrhagic fever is Lassa virus, which is an Arenavirus and is native to West Africa. (livescience.com)
Old world viruses include the Lassa virus (LASV) and Lujo fever in Africa, while New World viruses include several viral hemorrhagic fevers (Junin, Machupo, Guanarito, Sabia, Chapare) found in South America. (medscape.com)
There is currently no vaccine for the Lassa arenavirus, which causes Lassa fever. (news-medical.net)
The World Health Organization (WHO) has included Lassa fever in its R&D Blueprint list of epidemic threats needing urgent R&D action. (news-medical.net)
To gain insights into arenavirus fusion, we examined cell-cell fusion induced by the Old World Lassa virus (LASV) GPC complex. (omicsdi.org)
Brian Sullivan] Lassa fever is a disease that's caused by the arenavirus, Lassa virus. (cdc.gov)

Members of the Arenaviridae family are divided based on geographic distribution and genetic similarities as either Old World (Eastern hemisphere) or New World (Western hemisphere) arenavirdiae. (medscape.com)

This lipid also specifically promotes cell fusion mediated by Junin virus GPC, an unrelated New World arenavirus. (omicsdi.org)

Two disease-causing arenaviruses, known as Junín and Machupo, circulate through rodent populations, mainly in South America, and they can infect humans when people come in contact with affected rodents. (weizmann.org.au)

Preventive measures for arenavirus infections include control and exclusion of rodents in and around human dwellings. (cdc.gov)
The arenaviruses are a large group of viruses that typically affect rodents. (medscape.com)
Arenaviruses are single-stranded ribonucleic acid (RNA) viruses that cause chronic asymptomatic infections in rodents and zoonotically acquired disease in humans through rodent excreta, especially urine. (medscape.com)
Arenaviruses have been divided into 2 groups based on whether the virus is found to infect Old World (ie, Eastern Hemisphere) rodents (family Muridae, subfamily Murinae) or New World (ie, Western Hemisphere) rodents (family Muridae, subfamily Sigmodontinae). (medscape.com)
Some Old World arenaviruses appear to be passed from mother rodents to their offspring during pregnancy, and thus remain in the rodent population generation after generation. (unt.edu)
Some New World arenaviruses are transmitted among adult rodents, likely via fighting and inflicting bites. (unt.edu)
Thirty-four rodents captured in southern California were studied to increase our knowledge of the arenaviruses indigenous to the western United States. (ttu.edu)
An infectious arenavirus was isolated from 5 of 27 California mice but none of the 7 other rodents. (ttu.edu)
Arenaviruses are transmitted by rodents. (medscape.com)
The study, reported in Nature Communications , arose from an earlier research question in the group of Dr Ron Diskin of the Weizmann Institute's Structural Biology Department: how are certain arenaviruses able to move from rodents or other animals into humans? (weizmann.org.au)
The virus is an arenavirus, one that can infect rodents and then be transferred to humans. (nilesanimalhospital.com)

Arenaviruses and Hantavirus (a Bunyavirus) are primarily rodent-borne, whereas flaviviruses, as well as nairoviruses and phleboviruses (both bunyaviruses), are arthropod-borne. (medscape.com)
Ebola is one of several members of the Filovirus family of viruses that can cause hemorrhagic fevers, and there are at least three other families of viruses that also cause hemorrhagic fevers, including Bunyaviruses , Flavaviruses and Arenaviruses, Schmaljohn said. (livescience.com)
VHFs are caused by viruses of four distinct families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses. (brainandnervecenter.com)

Guanarito virus is one of the diseases derived from the family Arenaviruses, which can vary in severity in subgroups of Old World and New World viruses. (nilesanimalhospital.com)

The California Department of Health Services (CDHS) and the University of Texas Medical Branch (UTMB) recently identified evidence of infection with an arenavirus in three patients hospitalized with similar fatal illnesses. (cdc.gov)
Standard precautions should be used during treatment of patients with suspected arenavirus infection and standard precautions plus contact/droplet/aerosol-specific precautions should be used for patients with severe clinical manifestations ( 6,7 ). (cdc.gov)
In 1934, the prototypic arenavirus, lymphocytic choriomeningitis virus (LCMV), was first isolated during serial monkey passage of human material that was obtained from a fatal infection in the first documented epidemic of St. Louis encephalitis, a totally unrelated virus. (medscape.com)
Other arenaviruses from South America and Africa are classic causes of viral hemorrhagic fever syndrome, whereas others have been identified but not found to cause disease or even infection in humans. (medscape.com)
The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. (umassmed.edu)
Human infection with arenaviruses is incidental to the natural cycle of the viruses and occurs when an individual comes into contact with the excretions or materials contaminated with the excretions of an infected rodent, such as ingestion of contaminated food, or by direct contact of abraded or broken skin with rodent excrement. (unt.edu)
It is concluded that research efforts regarding human-pathogenic arenaviruses should maintain a balance between understanding both the macro-factors that may influence epidemic dynamics as well as the micro-scale factors that form the fundamental basis of infection. (questu.ca)
These findings can also be useful in international scenarios where the world is looking for innovative measures to curb COVID-19 infection. (clinicaltrials.gov)
The samples were screened at the National Institute for Communicable Diseases (NICD) for evidence of infection with known agents of the viral hemorrhagic fevers of Africa by reverse transcription-PCR (RT-PCR) for presence of viral nucleic acid, including 2 procedures with primers designed to detect all known Old World arenaviruses. (medscape.com)
Dengue fever, an increasingly common mosquito-borne infection in many parts of the world, including northern Australia, can act like a VHF if a previously infected patient is exposed to a different dengue subtype. (insidestory.org.au)

Human-pathogenic Arena viruses are the trigger of haemorrhagic fever diseases, which are endemic in various countries and continents (old world viruses and new world viruses). (altmeyers.org)

Several arenaviruses cause viral hemorrhagic fever syndromes in Africa and South America. (cdc.gov)

The South American hemorrhagic fever viruses belong to the Tacaribe complex or New World arenaviruses (e.g. (cdc.gov)
Since Tacaribe virus was found in 1956, new arenaviruses have been discovered on the average of every one to three years. (unt.edu)
Tacaribe complex viruses are generally associated with the New World rats and mice (family Muridae, subfamily Sigmodontinae). (unt.edu)

Bulletin of the World Health Organization, 55 (‎4)‎, 441 - 444. (who.int)
During the 2014/15 outbreak, the World Health Organization (WHO) recognized the need for a simple, point-of-care (POC) Ebola diagnostic and published target product profiles (TPPs) to encourage test development [ 10 , 11 ]. (biomedcentral.com)
For example, the strain of Ebola causing the current outbreak, Ebola Zaire, is believed to have been transferred to humans by fruit bats belonging to the Pteropodidae family, according to the World Health Organization (WHO). (livescience.com)
World Health Organization. (who.int)
In 1980, the year I started my clinical studies, the World Health Organization announced that smallpox, one of the most dread infections in human history, had been eradicated. (insidestory.org.au)
Communicable Surveillance & Response (CSR), World Health Organization. (cdc.gov)
11. World Health Organization. (who.int)

The emergence of SARS-CoV, in particular, demonstrated the considerable economic, political and psychological effects-in addition to the impact on public health-of an unexpected epidemic of a highly infectious, previously unknown agent in a highly connected and interdependent world. (who.int)
The new antibiotics and vaccines developed in the decades following the second world war had gone some way towards neutralising community fear of infectious diseases, and the success of the smallpox campaign reinforced the growing belief that the Age of Infections was coming to an end. (insidestory.org.au)
Comparing these viruses with members of the arenavirus family, not infectious to humans, the researchers noted that the non-infectious viruses did not completely fit a particular receptor - a protein complex on the cell membrane - that serves as a viral entry point into human cells. (weizmann.org.au)

however, human cases have been documented only in the Americans and Europe, thus it is the only Old World arenavirus found in both the Eastern and Western Hemisphere. (medscape.com)

Sequences of arenaviruses in L. rosalia and M. minutoides mice have been deposited in GenBank under accession nos. (cdc.gov)
By inoculating HLA transgenic mice with a panel of recombinant vaccinia viruses (rVACVs) expressing the different arenavirus proteins, we identified 10 HLA-A02 and 10 HLA-A03-restricted epitopes that are naturally processed in human antigen-presenting cells. (elsevier.com)
Importantly, we showed that immunization of HLA transgenic mice with an epitope cocktail generated simultaneous CD8 + T cell responses against all 7 arenaviruses, and protected mice against challenge with rVACVs expressing either Old or New World arenavirus glycoproteins. (elsevier.com)

The first arenavirus, lymphocytic choriomeningitis virus (LCMV) , was isolated in 1933 during a study of an epidemic of St. Louis encephalitis. (unt.edu)

The New World arenaviruses are further divided into 3 lineages designated clades: A, B, C. LCMV is the only arenavirus to exist in both areas but is classified as an Old World virus. (medscape.com)

The genus Arenavirus includes 22 viral species and 9 additional arenaviruses that have been recently discovered, for which taxonomic status remains pending. (medscape.com)
One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. (bvsalud.org)

Readers are then given a detailed assessment of the potential usefulness of synthetic antigens in the diagnosis of viral infections, including those caused by influenza virus, paramyxoviruses, arenaviruses, hepatitis B virus, poliovirus, hepatitis A virus, and herpesviruses. (who.int)

Arenavirus infections are relatively common in humans in some areas of the world and can cause severe illnesses. (unt.edu)
She had visited a tourist camp on the Zambezi River on July 30 and 31, 2008, and participated in a polocrosse tournament on August 1 and 2 (but neither event occurred within the known incubation period of arenavirus infections from the date of onset of her illness). (medscape.com)

The genetics, ecology, physical structure and effects of the viruses that cause hemorrhagic fevers in different parts of the world are quite diverse, he added. (livescience.com)

SNV is the prototypical New World Hantavirus and is the cause of the vast majority of cases of HCPS in the United States. (medscape.com)

Immunohistochemical tests of these tissues with polyclonal antibodies were negative for dengue virus, yellow fever virus, hantaviruses, arenaviruses and Ebola virus. (cdc.gov)
Five of the "New World" Hantaviruses cause HCPS in North America, while a few others cause disease in Central America and South America. (medscape.com)

Arenaviruses are the causative pathogens of severe hemorrhagic fever and aseptic meningitis in humans, for which no licensed vaccines are currently available. (elsevier.com)

The nucleotide sequence of the PCR products amplified from the patients essentially were identical and shared 87% identity with the Whitewater Arroyo (WWA) virus prototype strain (an arenavirus recovered from a Neotoma albigula [white-throated woodrat]) from New Mexico in the early 1990s). (cdc.gov)
LCM virus, associated with the house mouse ( Mus musculus ), is the only Old World arenavirus that occurs in the Americas. (cdc.gov)
Uno de los dos grupos de virus del género ARENAVIRUS y considerado parte del complejo del Nuevo Mundo. (bvsalud.org)
Her research focuses on host-virus interactions, particularly oncogenic murine retroviruses and the new world hemorrhagic fever arenaviruses. (uillinois.edu)

For some of these epitopes we were able to demonstrate crossreactive CD8 + T cell responses, further increasing the coverage afforded by the epitope set against each different arenavirus species. (elsevier.com)

Transmission electron microscopic (TEM) image depicting an arenavirus. (medscape.com)

In the world of public health, a lot of the media attention is focusing on the Zika outbreak in Latin America, but that's not the only disease on the rise. (nhpr.org)

Although the viruses are distributed all over the world, they have a higher occurrence in tropical areas, such as South America, Africa, and the Pacific Islands. (medscape.com)

A host of disease-causing viruses called 'arenaviruses' lurk in animal populations in various parts of the world, sometimes crossing over into humans. (weizmann.org.au)

Arenavirus entry into host cells occurs through a low pH-dependent fusion with late endosomes that is mediated by the viral glycoprotein complex (GPC). (omicsdi.org)

Morales issued the statement: "I want to denounce before the Bolivian people and the world that there's a coup d'état in the making. (trendsjournal.com)

VHFs are found around the world. (medlineplus.gov)

A number of arenaviruses cause hemorrhagic disease. (unt.edu)
Since its first discovery in Wuhan, China in late December, it has now become a pandemic disease claiming more than nine hundred forty-five thousand deaths world-wide so far. (clinicaltrials.gov)
Pathogenesis of arenavirus disease. (utmb.edu)

It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution. (uchicago.edu)

Organisms that survive primarily or entirely in the human host and are spread through sexual contact, droplet nuclei, and close physical contact can be readily carried to any part of the world. (cdc.gov)
Computational and functional analysis of the GP1-TfR1 interface reveals host range trade-offs in New-World arenaviruses. (meyerlab.org)

Anatomy4

Organisms42

Diseases9

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes16

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Humanities4

Information Science4

Named Groups2

Health Care2

Geographicals7

Experimental infection of the cane mouse Zygodontomys brevicauda (family Muridae) with guanarito virus (Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. (1/127)

Guanarito virus (Arenaviridae) isolates from endemic and outlying localities in Venezuela: sequence comparisons among and within strains isolated from Venezuelan hemorrhagic fever patients and rodents. (2/127)

Homologous and heterologous glycoproteins induce protection against Junin virus challenge in guinea pigs. (3/127)

The Whitewater Arroyo virus: natural evidence for genetic recombination among Tacaribe serocomplex viruses (family Arenaviridae). (4/127)

Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral hemorrhagic fever. (5/127)

Protection against simian immunodeficiency virus vaginal challenge by using Sabin poliovirus vectors. (6/127)

Transcription and RNA replication of tacaribe virus genome and antigenome analogs require N and L proteins: Z protein is an inhibitor of these processes. (7/127)

New World arenavirus clade C, but not clade A and B viruses, utilizes alpha-dystroglycan as its major receptor. (8/127)

Arenaviruses, New World

Arenaviruses, Old World

Arenavirus

Arenaviridae Infections

Lassa virus

Arenaviridae

Hemorrhagic Fevers, Viral

Platyrrhini

Junin virus

Hemorrhagic Fever, American

Cebidae

Pichinde virus

Virus Physiological Processes

Lymphocytic choriomeningitis virus

Cercopithecidae

Dystroglycans

Phylogeny

Transferrins

Callithrix

Filoviridae

Lassa Fever

Americas

Saguinus

Saimiri

Virus Internalization

Aotidae

Boidae

Receptors, Virus

Cebus

Vero Cells

Cercopithecus aethiops

Snakes

Rodent Diseases

Molecular Sequence Data

Rodentia

Nucleoproteins

Primates

North America

Receptors, Transferrin

Viral Proteins

Alouatta

Evolution, Molecular

Virus Attachment

Peromyscus

Nucleocapsid Proteins

Aotus trivirgatus

RNA, Viral

Inclusion Bodies, Viral

Species Specificity

Atelinae

Glycoproteins

History, Ancient

Electron Microscope Tomography

Host-Pathogen Interactions

Proprotein Convertases

South America

Strepsirhini

Cricetinae

World Health Organization

Viral Vaccines

Camelids, New World

Cell Line

Virus Release

Amino Acid Sequence

Antiviral Agents

World Health

Sequence Alignment

Genome, Viral

RNA Viruses

Base Sequence

Sequence Analysis, DNA

Callitrichinae

Pitheciidae

History, 15th Century

Viral Envelope Proteins

Biological Evolution

Lymphocytic Choriomeningitis

Indians, South American

Monkey Diseases

Leishmaniasis, Mucocutaneous