Arenavirus
Arenaviridae
A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). Infection in rodents is persistent and silent. Vertical transmission is through milk-, saliva-, or urine-borne routes. Horizontal transmission to humans, monkeys, and other animals is important.
Arenaviruses, New World
Lassa virus
Junin virus
Arenaviruses, Old World
Pichinde virus
Lymphocytic choriomeningitis virus
The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. In humans, infection with LCMV can be inapparent, or can present with an influenza-like illness, a benign aseptic meningitis, or a severe meningoencephalomyelitis. The virus can also infect monkeys, dogs, field mice, guinea pigs, and hamsters, the latter an epidemiologically important host.
Hemorrhagic Fever, American
Hemorrhagic Fevers, Viral
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
Reverse Genetics
Vero Cells
Sigmodontinae
Virus Internalization
Cercopithecus aethiops
Lymphocytic Choriomeningitis
A form of meningitis caused by LYMPHOCYTIC CHORIOMENINGITIS VIRUS. MICE and other rodents serve as the natural hosts, and infection in humans usually occurs through inhalation or ingestion of infectious particles. Clinical manifestations include an influenza-like syndrome followed by stiff neck, alterations of mentation, ATAXIA, and incontinence. Maternal infections may result in fetal malformations and injury, including neonatal HYDROCEPHALUS, aqueductal stenosis, CHORIORETINITIS, and MICROCEPHALY. (From Joynt, Clinical Neurology, 1996, Ch26, pp1-3)
Virus Release
RING Finger Domains
A zinc-binding domain defined by the sequence Cysteine-X2-Cysteine-X(9-39)-Cysteine-X(l-3)-His-X(2-3)-Cysteine-X2-Cysteine -X(4-48)-Cysteine-X2-Cysteine, where X is any amino acid. The RING finger motif binds two atoms of zinc, with each zinc atom ligated tetrahedrally by either four cysteines or three cysteines and a histidine. The motif also forms into a unitary structure with a central cross-brace region and is found in many proteins that are involved in protein-protein interactions. The acronym RING stands for Really Interesting New Gene.
Dystroglycans
Proprotein Convertases
Viral Envelope Proteins
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Cricetinae
Rodent Diseases
Transfer Agreement
National Institute of Allergy and Infectious Diseases (U.S.)
Waste Management
Databases, Protein
National Institute of General Medical Sciences (U.S.)
Component of the NATIONAL INSTITUTES OF HEALTH. It conducts and supports basic biomedical research that is not targeted to specific diseases and funds studies on genes, proteins, and cells, as well as on fundamental processes like communication within and between cells and metabolism. It was established in 1962.
Natural rodent host associations of Guanarito and pirital viruses (Family Arenaviridae) in central Venezuela. (1/92)
The objective of this study was to elucidate the natural rodent host relationships of Guanarito and Pirital viruses (family Arenaviridae) in the plains of central Venezuela. Ninety-two arenavirus isolates from 607 animals, representing 10 different rodent species, were characterized to the level of serotype. The 92 isolates comprised 19 Guanarito virus strains and 73 Pirital virus strains. The 19 Guanarito virus isolates were from Zygodontomys brevicauda; 72 (98.6%) of the 73 Pirital virus isolates were from Sigmodon alstoni. These results indicate that the natural rodent associations of these 2 sympatric arenaviruses are highly specific and that Z brevicauda and S. alstoni are the principal rodent hosts of Guanarito and Pirital viruses, respectively. (+info)Fatal illnesses associated with a new world arenavirus--California, 1999-2000. (2/92)
The California Department of Health Services (CDHS) and the University of Texas Medical Branch (UTMB) recently identified evidence of infection with an arenavirus in three patients hospitalized with similar fatal illnesses. This report summarizes the investigation of these cases. (+info)The viral transmembrane superfamily: possible divergence of Arenavirus and Filovirus glycoproteins from a common RNA virus ancestor. (3/92)
BACKGROUND: Recent studies of viral entry proteins from influenza, measles, human immunodeficiency virus, type 1 (HIV-1), and Ebola virus have shown, first with molecular modeling, and then X-ray crystallographic or other biophysical studies, that these disparate viruses share a coiled-coil type of entry protein. RESULTS: Structural models of the transmembrane glycoproteins (GP-2) of the Arenaviruses, lymphochoriomeningitis virus (LCMV) and Lassa fever virus, are presented, based on consistent structural propensities despite variation in the amino acid sequence. The principal features of the model, a hydrophobic amino terminus, and two antiparallel helices separated by a glycosylated, antigenic apex, are common to a number of otherwise disparate families of enveloped RNA viruses. Within the first amphipathic helix, demonstrable by circular dichroism of a peptide fragment, there is a highly conserved heptad repeat pattern proposed to mediate multimerization by coiled-coil interactions. The amino terminal 18 amino acids are 28% identical and 50% highly similar to the corresponding region of Ebola, a member of the Filovirus family. Within the second, charged helix just prior to membrane insertion there is also high similarity over the central 18 amino acids in corresponding regions of Lassa and Ebola, which may be further related to the similar region of HIV-1 defining a potent antiviral peptide analogue. CONCLUSIONS: These findings indicate a common pattern of structure and function among viral transmembrane fusion proteins from a number of virus families. Such a pattern may define a viral transmembrane superfamily that evolved from a common precursor eons ago. (+info)Arenavirus antibody in rodents indigenous to coastal southern California. (4/92)
The purpose of this study was to extend our knowledge on the geographic and natural rodent host ranges of New World arenaviruses in California. Sera from 1,094 sigmodontine and 112 murine rodents were tested for antibody against Whitewater Arroyo and Amapari viruses. Antibody was found in 55 (4.6%) of the 1,206 rodents: 4 from northwestern San Diego County, 3 from Los Angeles County, and 48 from Orange County. The antibody-positive rodents included 8 (7.8%) of 103 Neotoma fuscipes, 1 (0.6%) of 180 Neotoma lepida, 1 (3.1%) of 32 Peromyscus boylii, 8 (11.0%) of 73 Peromyscus californicus, 1 (1.2%) of 85 Peromyscus eremicus, 30 (8.5%) of 353 Peromyscus maniculatus, and 6 (2.2%) of 268 Reithrodontomys megalotis. This study provides the first evidence that New World arenaviruses occur in Los Angeles and Orange counties and northwestern San Diego County, and the first evidence that Peromyscus and Reithrodontomys species are naturally infected with New World arenaviruses. (+info)Allpahuayo virus: a newly recognized arenavirus (arenaviridae) from arboreal rice rats (oecomys bicolor and oecomys paricola) in northeastern peru. (5/92)
Allpahuayo virus was initially isolated from arboreal rice rats (Oecomys bicolor and Oecomys paricola) collected during 1997 at the Allpahuayo Biological Station in northeastern Peru. Serological and genetic studies identified the virus as a new member of the Tacaribe complex of the genus Arenavirus. The small (S) segment of the Allpahuayo virus prototype strain CLHP-2098 (Accession No. AY012686) was sequenced, as well as that of sympatric isolate CLHP-2472 (Accession No. AY012687), from the same rodent species. The S segment was 3382 bases in length and phylogenetic analysis indicated that Allpahuayo is a sister virus to Pichinde in clade A. Two ambisense, nonoverlapping reading frames were identified, which result in two predicted gene products, a glycoprotein precursor (GPC) and a nucleocapsid protein (NP). A predicted stable single hairpin secondary structure was identified in the intergenic region between GPC and NP. Details of the genetic organization of Allpahuayo virus are discussed. (+info)Transmission of an arenavirus in white-throated woodrats (Neotoma albigula), southeastern Colorado, 1995-1999. (6/92)
From 1995 to 1999, we conducted longitudinal studies of white- throated woodrats (Neotoma albigula) in southeastern Colorado. Forty-five (42.9%) of 105 female and 15 (26.8%) of 56 male N. albigula had antibodies against Whitewater Arroyo virus (WWAV). Sixteen female and three male N. albigula seroconverted during the study period, most of them during July-November, when population densities are highest. Analyses of longevity data, minimum numbers alive and infected, movements, and weight data suggest that the dominant mode of WWAV transmission among white-throated woodrats in Colorado is direct contact. WWAV was recently reported to cause fatal infection in humans. Our findings will lead to better assessment of the public health threat posed by infected woodrats and may be useful in predicting periods of increased risk for human infection. (+info)Geographic distribution and genetic diversity of Whitewater Arroyo virus in the southwestern United States. (7/92)
The purpose of this study was to extend our knowledge of the geographic distribution and genetic diversity of the arenavirus(es) associated with Neotoma species (woodrats) in the southwestern United States. Infectious arenavirus was recovered from 14 (3.3%) of 425 woodrats. The virus-positive species included N. albigula in New Mexico and Oklahoma, N. cinerea in Utah, N. mexicana in New Mexico and Utah, and N. micropus in Texas. Analyses of viral nucleocapsid protein gene sequence data indicated that all the isolates were strains of the Whitewater Arroyo virus, an arenavirus previously known only from northwestern New Mexico. Analyses of the sequence data also indicated that there can be substantial genetic diversity among strains of Whitewater Arroyo virus from conspecific woodrats collected from different localities and substantial genetic diversity among strains from different woodrat species collected from the same locality. (+info)Common antiviral cytotoxic t-lymphocyte epitope for diverse arenaviruses. (8/92)
Members of the Arenaviridae family have been isolated from mammalian hosts in disparate geographic locations, leading to their grouping as Old World types (i.e., lymphocytic choriomeningitis virus [LCMV], Lassa fever virus [LFV], Mopeia virus, and Mobala virus) and New World types (i.e., Junin, Machupo, Tacaribe, and Sabia viruses) (C. J. Peters, M. J. Buchmeier, P. E. Rollin, and T. G. Ksiazek, p. 1521-1551, in B. N. Fields, D. M. Knipe, and P. M. Howley [ed.], Fields virology, 3rd ed., 1996; P. J. Southern, p. 1505-1519, in B. N. Fields, D. M. Knipe, and P. M. Howley [ed.], Fields virology, 3rd ed., 1996). Several types in both groups-LFV, Junin, Machupo, and Sabia viruses-cause severe and often lethal human diseases. By sequence comparison, we noted that eight Old World and New World arenaviruses share several amino acids with the nucleoprotein (NP) that consists of amino acids (aa) 118 to 126 (NP 118-126) (RPQASGVYM) of LCMV that comprise the immunodominant cytotoxic T-lymphocyte (CTL) epitope for H-2(d) mice (32). This L(d)-restricted epitope constituted >97% of the total bulk CTLs produced in the specific antiviral or clonal responses of H-2(d) BALB mice. NP 118-126 of the Old World arenaviruses LFV, Mopeia virus, and LCMV and the New World arenavirus Sabia virus bound at high affinity to L(d). The primary H-2(d) CTL anti-LCMV response as well as that of a CTL clone responsive to LCMV NP 118-126 recognized target cells coated with NP 118-126 peptides derived from LCMV, LFV, and Mopeia virus but not Sabia virus, indicating that a common functional NP epitope exists among Old World arenaviruses. Use of site-specific amino acid exchanges in the NP CTL epitope among these arenaviruses identified amino acids involved in major histocompatibility complex binding and CTL recognition. (+info) Arenaviridae Infections are viral diseases caused by members of the Arenaviridae family, which includes arenaviruses and lymphocytic choriomeningitis virus (LCMV). These infections can affect various parts of the body and can range from mild to severe.
The symptoms of Arenaviridae infections can vary depending on the specific virus causing the infection, but they may include:
* Fever
* Headache
* Muscle pain
* Joint pain
* Sore throat
* Swollen lymph nodes
* Rash
* Seizures
* Meningitis
* Encephalitis (inflammation of the brain)
Some Arenaviridae infections can be transmitted to humans through contact with infected rodents or other animals, while others are spread by blood transfusions or organ transplantation. There is no specific treatment for Arenaviridae infections, and treatment is primarily focused on relieving symptoms and managing complications.
Examples of Arenaviridae infections include:
* Lymphocytic choriomeningitis (LCMV)
* Venezuelan equine encephalitis (VEE)
* Eastern equine encephalitis (EEE)
* Western equine encephalitis (WEE)
* Sabia virus infection
It's important to note that Arenaviridae infections can be severe and potentially life-threatening, so if you suspect you or someone else may have been infected, it's important to seek medical attention immediately.
Hemorrhagic fever, American (HFA) is a severe and potentially life-threatening viral disease that is transmitted through contact with infected ticks. It is caused by the bacterium Rickettsia rickettsii and is found primarily in the United States and parts of Central and South America.
The symptoms of HFA can include fever, headache, muscle and joint pain, and a characteristic rash that appears on the wrists and ankles. In severe cases, the disease can lead to bleeding under the skin, internal organs, and into the lungs, which can be fatal if not treated promptly.
Diagnosis of HFA is based on a combination of physical examination, laboratory tests, and medical history. Treatment typically involves antibiotics and supportive care to manage symptoms and prevent complications. Prevention measures include avoiding tick habitats, wearing protective clothing, and using insect repellents when outdoors in areas where the disease is common.
Previous article What Is A Hemorrhagic Fever, African?
Hemorrhagic fever, viral refers to a group of infectious diseases caused by viruses that affect the blood vessels and can cause bleeding. These fevers are characterized by high fever, severe headache, muscle pain, and weakness, followed by bleeding from the skin, eyes, or gastrointestinal tract.
Some of the common types of hemorrhagic fever, viral include:
1. Ebola virus disease (EVD): a severe and often fatal illness caused by the Ebola virus, which is transmitted through contact with infected bodily fluids, such as blood, sweat, and saliva.
2. Marburg virus disease (MVD): a highly contagious and deadly illness caused by the Marburg virus, which is also transmitted through contact with infected bodily fluids.
3. Lassa fever: a viral hemorrhagic fever that is common in West Africa and is caused by the Lassa virus, which is transmitted through contact with infected rodents.
4. Crimean-Congo hemorrhagic fever (CCHF): a widespread viral disease that affects the Balkans, the Middle East, and parts of Africa, and is caused by the Crimean-Congo hemorrhagic fever virus, which is transmitted through contact with infected ticks.
5. Bolivian hemorrhagic fever (BHF): a rare and potentially deadly viral disease that is caused by the Machupo virus and is found in Bolivia and other parts of South America.
These diseases can be diagnosed through laboratory tests, such as PCR (polymerase chain reaction) or ELISA (enzyme-linked immunosorbent assay), and are typically treated with supportive care, such as fluid replacement and pain management, as well as antiviral medications in some cases.
Prevention of hemorrhagic fever, viral includes avoiding contact with infected individuals, wearing protective clothing and equipment, and using insecticides to prevent tick bites. Vaccines are also available for some of the diseases, such as Ebola and Marburg, but they are not widely available or effective against all strains of the virus.
Overall, hemorrhagic fever is a serious and potentially deadly condition that requires prompt medical attention and appropriate treatment to prevent complications and improve outcomes.
Lassa fever is a viral hemorrhagic fever that is endemic in parts of West Africa, particularly in Nigeria, Sierra Leone, Liberia and Guinea. It is caused by the Lassa virus, which is transmitted to humans through contact with infected rodents, such as rats.
The symptoms of Lassa fever can vary from mild to severe and include fever, headache, muscle pain, vomiting, diarrhea, and bleeding. In severe cases, the virus can cause multi-organ failure and death.
There is no specific treatment for Lassa fever, but supportive care, such as intravenous fluids and oxygen therapy, can help manage symptoms. Ribavirin, an antiviral drug, has been shown to be effective in treating the virus in some cases.
Prevention of Lassa fever involves reducing exposure to infected rodents, such as by storing food in rat-proof containers and avoiding contact with rodents that may be carrying the virus. Vaccines are also being developed to protect against the virus.
Overall, Lassa fever is a serious and potentially deadly disease that requires prompt medical attention if symptoms persist or worsen over time. Early diagnosis and treatment can improve outcomes for patients infected with the virus.
Lymphocytic choriomeningitis (LCM) is a rare viral infection that affects the brain and spinal cord, causing inflammation and damage to these tissues. It is caused by a virus called LCM virus, which is transmitted through the bite of an infected mouse or rat.
The symptoms of LCM can vary depending on the severity of the infection, but they typically include fever, headache, neck stiffness, and sensitivity to light. In severe cases, LCM can cause meningitis, encephalitis (inflammation of the brain), and even death.
The diagnosis of LCM is based on a combination of clinical symptoms, laboratory tests, and imaging studies such as MRI or CT scans. Laboratory tests may include blood tests to detect the presence of antibodies against the virus, as well as tests to assess liver function and other organ systems.
Treatment of LCM typically involves supportive care, such as intravenous fluids, oxygen therapy, and pain management. Antiviral medications may also be used in some cases. In severe cases, hospitalization may be required to monitor and treat the patient.
Prevention of LCM primarily involves avoiding contact with infected rodents, particularly during pregnancy and childhood when the risk of infection is higher. Good hygiene practices, such as frequent handwashing, can also help reduce the risk of transmission. Vaccines are not available for LCM, but research is ongoing to develop one.
The prognosis for LCM varies depending on the severity of the infection and the promptness and effectiveness of treatment. In general, the outcome is good for patients with mild symptoms, but those with severe infections may experience long-term neurological problems or death.
Rodent diseases are infectious conditions that affect rodents, such as mice and rats. These diseases can be transmitted to humans through contact with infected animals or their environments, and can cause a range of symptoms, including fever, headache, and muscle pain. Some common examples of rodent diseases include:
1. Hantavirus pulmonary syndrome (HPS): This is a severe respiratory disease caused by the hantavirus, which is found in the urine and saliva of infected rodents. Symptoms of HPS can include fever, headache, muscle pain, and difficulty breathing.
2. Leptospirosis: This is a bacterial infection caused by the bacterium Leptospira, which is found in the urine of infected rodents. Symptoms can include fever, headache, muscle pain, and jaundice (yellowing of the skin and eyes).
3. Rat-bite fever: This is a bacterial infection caused by the bacterium Streptobacillus moniliformis, which is found in the saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
4. Lymphocytic choriomeningitis (LCM): This is a viral infection caused by the lymphocytic choriomeningitis virus (LCMV), which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and meningitis (inflammation of the membranes surrounding the brain and spinal cord).
5. Tularemia: This is a bacterial infection caused by the bacterium Francisella tularensis, which is found in the urine and saliva of infected rodents. Symptoms can include fever, headache, muscle pain, and swollen lymph nodes.
These are just a few examples of the many diseases that can be transmitted to humans through contact with rodents. It is important to take precautions when handling or removing rodents, as they can pose a serious health risk. If you suspect that you have been exposed to a rodent-borne disease, it is important to seek medical attention as soon as possible.
Arenavirus
At least eight arenaviruses are known to cause human disease. The diseases derived from arenaviruses range in severity. Aseptic ... The life cycle of the arenavirus is restricted to the cell cytoplasm.[citation needed] Arenaviruses have a segmented RNA genome ... Arenaviruses "Arenavirus". NCBI Taxonomy Browser. 11618. (Webarchive template wayback links, CS1 maint: uses authors parameter ... arenaviruses were formerly all placed in the genus Arenavirus, but in 2014 were divided into the genera Mammarenavirus for ...
Mopeia mammarenavirus
It is of the "Old World" Arenavirus lineage and is closely related to Lassa mammarenavirus, sharing 75% of its amino acid ... Wulff H, McIntosh BM, Hamner DB, Johnson KM (1977). "Isolation of an arenavirus closely related to Lassa virus from Mastomys ... Johnson KM, Taylor P, Elliott LH, Tomori O (November 1981). "Recovery of a Lassa-related arenavirus in Zimbabwe". The American ... Gonzalez JP, Emonet S, de Lamballerie X, Charrel R (2007). Childs JE, Mackenzie JS, Richt JA (eds.). "Arenaviruses". Wildlife ...
Argentinian mammarenavirus
... , better known as the Junin virus or JunÃn virus (JUNV), is an arenavirus in the Mammarenavirus genus ... Enria, D. A.; Oro, J. G. Barrera (2002). "Junin Virus Vaccines". Arenaviruses II. Current Topics in Microbiology and Immunology ... Peters CJ; Buchmeir M; Rollin Pierre E; Ksiazek Thomas G (1996). Arenaviruses. Field's Virology Third Edition. Maiztegui JI, ...
Flexal mammarenavirus
Zuckerman 2014, p. 10 "Viral Hemorrhagic Fevers Caused by Arenaviruses" (PDF). The Center for Food Security and Public Health. ... Zuckerman, Ben (2014). Howard, C R (ed.). Arenaviruses. Elsevier. p. 7. ISBN 9780080877372. ... an arenavirus with a mammalian host. It was first found in semiaquatic rodents of the genus Oryzomys in tropical forest in the ...
Patricia Ann Webb
Wulff, Herta; Lange, James V.; Webb, Patricia A. (1978). "Interrelationships Among Arenaviruses Measured by Indirect ...
Oyewale Tomori
Johnson, K. M.; Taylor, P.; Tomori, O.; Elliott, L. H. (1981-11-01). "Recovery of a Lassa-Related Arenavirus in Zimbabwe". The ... 1987 The global virome project Recovery of a Lassa-related arenavirus in Zimbabwe Toward a common secure future: four global ... and cross-reactivity with other arenaviruses Yellow fever: the recurring plague Randomised controlled trials for Ebola: ... and cross-reactivity with other arenaviruses". Virology. 113 (1): 73-85. doi:10.1016/0042-6822(81)90137-9. PMID 6267791. Tomori ...
Lujo mammarenavirus
"Discovery of new arenavirus associated with hemorrhagic fever - first identified in nearly four decades". News-Medical.net. ... The identification of this virus was the first new arenavirus discovered in over 40 years. The first case was a female travel ... The distribution of this newly described arenavirus is uncertain. To date this virus has only been reported from a patient from ... Sequencing of the viral genome has shown that this virus belongs to the Old World arenavirus group. Comparisons with other ...
Bear Canyon mammarenavirus
... all three being New World arenaviruses. The virus is named after Bear Canyon, the area it was originally discovered in. Cajimat ... An Arenavirus Naturally Associated with the California Mouse (Peromyscus californicus)". Emerging Infectious Diseases. 8 (7): ... "Principal host relationships and evolutionary history of the North American arenaviruses". Virology. 367 (2): 235-243. doi: ...
Lassa mammarenavirus
Arenaviruses use a cap snatching strategy to gain the cap structures from the cellular mRNAs, and it is mediated by the ... Alpha-dystroglycan is also used as a receptor by viruses of the New World clade C arenaviruses (Oliveros and Latino viruses). ... The life cycle of Lassa mammarenavirus is similar to the Old World arenaviruses. Lassa mammarenavirus enters the cell by the ... In addition, GP1 amino acid position 259 also appears to be important, since all arenaviruses showing high-affinity alpha-DG ...
Lunk
... can also refer to: In reality An arenavirus (LNKV). Lunk, a nickname for Steve Lundquist an Olympic swimmer A lunk alarm ...
Morogoro virus
... is an East African arenavirus infecting the multimammate mouse (Mastomys natalensis). The virus is genetically ... as this has been suggested for other arenaviruses. Günther S, Hoofd G, Charrel R, Röser C, Becker-Ziaja B, Lloyd G, Sabuni C, ... an African arenavirus closely related to Lassa virus, in its natural reservoir host Mastomys natalensis". Sci Rep. 5: 10445. ... "Mopeia virus-related arenavirus in natal multimammate mice, Morogoro, Tanzania". Emerg Infect Dis. 15 (12): 2008-2012. doi: ...
Jean-Paul Gonzalez
Gonzalez JP, Sanchez A, Rico-Hesse R (July 1995). "Molecular phylogeny of Guanarito virus, an emerging arenavirus affecting ... Arenavirus, Hantavirus, Crimean Congo Hemorrhagic virus and others. In the late 90s he began working as a professor of ... "Phylogeny and evolution of old world arenaviruses". Virology. 350 (2): 251-7. doi:10.1016/j.virol.2006.01.026. PMID 16494913. ...
Lymphocytic choriomeningitis
The first arenavirus, Lymphocytic choriomeningitis mammarenavirus (LCMV), was isolated in 1933 by Charles Armstrong during a ... Nucleoside analog ribavirin is used in some cases due to the inhibitory effect the agent has in vitro on arenaviruses. However ... LCM is the archetypal arenavirus, and was instrumental in research which uncovered the major pathogenetic mechanisms of all ... "A New Arenavirus in a Cluster of Fatal Transplant-Associated Diseases". The New England Journal of Medicine. 358 (10): 991-998 ...
Whitewater Arroyo mammarenavirus
Arenavirus-specific RNA was detected in each patient using RT-PCR. The nucleotide sequence of the patients were essentially ... Like other arenaviruses, WWAV appears to be transmitted through rodents. Therefore, direct contact with rodents, their feces, ... in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ... Although it is unclear if WWAV can be transmitted nosocomially, other arenaviruses have been transmitted through contact with ...
Digital transcriptome subtraction
Simultaneously to the MCV discovery, this approach was used to implicate a novel arenavirus as cause of fatality in a case ... "A new arenavirus in a cluster of fatal transplant-associated diseases". N Engl J Med. 10. 358 (10): 991-998. CiteSeerX 10.1. ...
Elina Zúñiga
Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection. Cell Host ... DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection. PLoS Pathog. 2018 Jul 12;14(7): ... "Plasmacytoid dendritic cells are productively infected and activated through TLR-7 early after arenavirus infection". Cell Host ... "DDX3 suppresses type I interferons and favors viral replication during Arenavirus infection". PLOS Pathogens. 14 (7): e1007125 ...
IFITM1
... arenavirus, or murine leukaemia virus infection. IFITM proteins inhibit viral membrane and cellular endosomal or lysosomal ...
Venezuelan hemorrhagic fever
... the Old World arenaviruses, and the New World arenaviruses. Old World arenaviruses include lymphocytic choriomeningitis virus ... New world arena viruses are further broken down into three clades, A, B, and C. The Guanarito arena virus belongs to clade B ... Arenaviruses causing hemorrhagic fevers, along with a genus of virus called filoviruses, were categorized in Category A; these ... VHF has many similarities to Lassa fever and to the arenavirus hemorrhagic fevers that occur in Argentina and Bolivia. It ...
Mammarenavirus
Arenavirus comes from the Latin arena (sand) for the sandy appearance of the virions. The following species are recognized: ... The name is a portmanteau of mammal and the former name Arenavirus, and differentiates it from the reptile-associated ... in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ...
Viral hemorrhagic fever
Post-exposure prophylactic (preventive) ribavirin may be effective for some bunyavirus and arenavirus infections. VHF isolation ... and the South American hemorrhagic fevers caused by arenaviruses, but only in a small minority of patients with dengue or Rift ... a New Hemorrhagic Fever-Associated Arenavirus from Southern Africa". PLOS Pathog. 5 (5): e1000455. doi:10.1371/journal.ppat. ...
Brazilian hemorrhagic fever
Ribavirin is thought to be effective in treating the illness, similar to other arenaviruses. Compared to the patients who did ... Brazilian mammarenavirus is one of the arenaviruses from South America to cause hemorrhagic fever. It shares a common ... Brazilian hemorrhagic fever (BzHF) is an infectious disease caused by Brazilian mammarenavirus, an arenavirus. ...
Big-eared woodrat
"Principal host relationships and evolutionary history of the North American arenaviruses". Virology. 367 (2): 235-243. doi: ...
Cocoliztli epidemics
They suggested that scholars consider New World arenaviruses and the role these pathogens may have played in colonial disease ... These animals may have carried arenaviruses capable of causing hemorrhagic fevers. The effects of drought, combined with the ... Marr and Kiracofe theorized that arenaviruses, mainly affecting rodents, were not prominent in the pre-Columbian Americas. ... brought these arenaviruses into much closer contact with people. Some subsequent research has focused on the viral hemorrhagic ...
Chapare mammarenavirus
in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ... Like other members of the Arenavirus family, the specific zoonotic reservoir and primary transmission vector is suspected to be ... a newly discovered arenavirus isolated from a fatal hemorrhagic fever case in Bolivia". PLOS Pathog. 4 (4): e1000047. doi: ...
Lassa fever
Specifically it is an old world arenavirus, which is enveloped, single-stranded, and bi-segmented RNA. This virus has both a ...
Argentine hemorrhagic fever
It is caused by the JunÃn virus (an arenavirus, closely related to the Machupo virus, causative agent of Bolivian hemorrhagic ... "Comparative analysis of disease pathogenesis and molecular mechanisms of New World and Old World arenavirus infections". The ...
Marsh rice rat
Prevalence of antibodies to arenaviruses in rodents from the southern and western United States: evidence for an arenavirus ... An arenavirus normally associated with woodrats (Neotoma) has also been found in Florida marsh rice rats. Antibodies against ...
Quaranjavirus
The virus particle contains around ten ribosome-like granules, a feature of arenaviruses. It bears surface projections ... Zeller and colleagues suggested that they should be classified as arenaviruses, but this was not accepted by the International ...
Bat virome
Arenaviruses are mainly associated with rodents, though some can cause illness in humans. The first arenavirus identified in ...
Cap snatching
"The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription". PLOS Pathogens. 6 (9 ...
Arenaviruses (Arenaviridae) | Viral Hemorrhagic Fevers (VHFs) | CDC
Since then, new arenaviruses have been discovered regularly.. How viruses in the Arenavirus family spread. While rodent hosts ... Discovery of Arenaviruses. Lymphocytic choriomeningitis virus (LCMV) was the first arenavirus identified. It was isolated in ... Old World/New World Arenaviruses. Arenaviruses are divided into two groups - New World and Old World viruses - based on genetic ... LCMV, classified as an Old World arenavirus, is the only arenavirus found in both the Western and Eastern Hemisphere. ...
Arenaviruses Medication: Antivirals
The genus Arenavirus includes 22 viral species and 9 additional arenaviruses that have been recently discovered, for which ... Arenaviruses are single-stranded ribonucleic acid (RNA) viruses that cause chronic infections in rodents and zoonotically ... encoded search term (Arenaviruses) and Arenaviruses What to Read Next on Medscape ... Arenaviruses Medication. Updated: May 12, 2019 * Author: Sandra G Gompf, MD, FACP, FIDSA; Chief Editor: Pranatharthi Haran ...
Novel Arenavirus, Zambia - Volume 17, Number 10-October 2011 - Emerging Infectious Diseases journal - CDC
To investigate arenavirus in Zambia, we characterized virus from the kidneys of 5 arenavirus RNA-positive rodents (Mastomys ... Such elucidation can lead to discovery of new arenaviruses, as demonstrated by isolation of a pathogenic New World arenavirus ... Günther S, Hoofd G, Charrel R, Roser C, Becker-Ziaja B, Lloyd G, Mopeia virus-related arenavirus in natal multimammate mice, ... Paweska JT, Sewlall NH, Ksiazek TG, Blumberg LH, Hale MJ, Lipkin WI, Nosocomial outbreak of novel arenavirus infection, ...
Novel Arenavirus Causes Mystery Illness in Zambia and South Africa | Blogs | CDC
Novel Arenavirus Causes Mystery Illness in Zambia and South Africa - Sharing our stories on preparing for and responding to ... Novel Arenavirus Causes Mystery Illness in Zambia and South Africa. Posted on October 17, 2008. by Ali S. Khan ... 2 comments on "Novel Arenavirus Causes Mystery Illness in Zambia and South Africa" Comments listed below are posted by ... a member of the arenavirus family, which is spread from infected Muridae rodents to humans when we ingest, inhale, or bring ...
An effective multi-pathogen vaccine targeting filoviruses and an arenavirus - Oxford Vaccine Group
New World Arenavirus - Guanarito Virus| CDC
A subpopulation of arenavirus nucleoprotein localizes to mitochondria. | Sci Rep;11(1): 21048, 2021 10 26. | MEDLINE
A subpopulation of arenavirus nucleoprotein localizes to mitochondria. A subpopulation of arenavirus nucleoprotein localizes to ... In support of MTS-independent translocation, we did not detect cleavage of the putative MTSs of arenavirus NPs in reptilian or ... We speculate that by targeting the mitochondria arenaviruses aim to alter mitochondrial metabolism and homeostasis or affect ... Herein we show that the nucleoprotein (NP) of arenaviruses enters the mitochondria of infected cells, affecting the ...
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Arenaviruses /
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Involvement of cellular proteins in Junin arenavirus entry<...
title = "Involvement of cellular proteins in Junin arenavirus entry",. abstract = "Junin arenavirus (JUNV) entry is dependent ... N2 - Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin ... AB - Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin ... Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin ...
ArboCat Virus: Ippy (IPPYV)
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MeSH Browser
Arenavirus [B04.820.480.500.070] * Arenaviruses, New World [B04.820.480.500.070.095] * Arenaviruses, Old World [B04.820.480.500 ... It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships ... It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships ... Arenavirus Preferred Term Term UI T054015. Date01/01/1999. LexicalTag NON. ThesaurusID NLM (1994). ...
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Association Kwata - Publications scientifiquesJunin2
- Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin cytoskeleton as well as the dynamics of microtubules. (elsevier.com)
- 17. Involvement of cellular proteins in Junin arenavirus entry. (nih.gov)
Lassa7
- Clinical experience with ribavirin in the treatment of Arenavirus infections is primarily with Lassa fever, but anecdotal experience in the South American arenaviruses also exists. (medscape.com)
- As a country in which Lassa fever is en- virus (LASV). (cdc.gov)
- Zoonotic disease nidality describes the phe- www.shermantraps.com/) at 8 sites across Lassa fever-en- nomenon in which geographic occurrence of a zoonotic demic and -nonendemic areas in Nigeria (Figure 1). (cdc.gov)
- A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. (lookformedical.com)
- Lassa fever is an acute viral haemorrhagic illness caused by Lassa virus, a member of the arenavirus family of viruses. (who.int)
- Sequence analysis reveals that Lujo is a new arenavirus, genetically distinct from other members of the family which includes Lassa virus. (virology.ws)
- Arenaviruses, things like Lassa fever have come from rodents. (ibiology.org)
Pathogenic arenaviruses1
- An Institut Pasteur team has successfully developed a pentavalent vaccine against the five pathogenic arenaviruses circulating in South America and tested it. (pasteur.fr)
Hantavirus1
- Clinically used in combination with interferon for hepatitis C, as aerosol for respiratory syncytial virus, and as potential prophylaxis and/or treatment of Congo-Crimean hemorrhagic fever, hantavirus infections, and Arenavirus hemorrhagic fevers. (medscape.com)
Viruses4
- Arenaviruses are divided into two groups - New World and Old World viruses - based on genetic differences as well as where the viruses are geographically distributed. (cdc.gov)
- One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. (lookformedical.com)
- A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). (lookformedical.com)
- Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD). (lookformedical.com)
Hemorrhagic fever4
- Genetic detection and characterization of lujo virus, a new hemorrhagic Fever-associated arenavirus from southern Africa. (medscape.com)
- A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. (lookformedical.com)
- A new member of the arenavirus family, Lujo virus, has been identified in patients who died during an outbreak of hemorrhagic fever in late 2008. (virology.ws)
- TfR has been reported to have ferritin-independent functions in T cell development, immunological synapse formation and galectin-3-mediated cell death, and to be a cell entry receptor for New World hemorrhagic fever arenaviruses (2, 4, 7). (rndsystems.com)
Viral1
- L phylogroups (A-I and A-II) are infected with LASV and assa fever, a viral hemorrhagic disease, is estimated other arenaviruses, and 2) identify the limits of distribution to infect 150,000-300,000 persons every year, kill- of these phylogroups within Nigeria. (cdc.gov)
Genus1
- The genus Mammarenavirus is dominated by rodent-borne arenaviruses, several of which have been identified as the causative agents behind hemorrhagic fevers and neurological infections in humans. (helsinki.fi)
Rodents3
- The types of rodents that spread arenaviruses are located across much of the world, including Europe, Asia, Africa, and the Americas. (cdc.gov)
- Most infections spread among adult rodents through scratches and bites, although for certain arenaviruses, the virus passes from mother to offspring during pregnancy. (cdc.gov)
- In some instances, arenaviruses can spread to people when consuming infected rodents as a food source. (cdc.gov)
Reptilian2
- In support of MTS-independent translocation, we did not detect cleavage of the putative MTSs of arenavirus NPs in reptilian or mammalian cells . (bvsalud.org)
- The pseudoviruses with reptarenavirus GPs served to demonstrate that the majority of arenavirus GPs could mediate entry to both mammalian and reptilian cells but at varying efficiencies. (helsinki.fi)
Morphology2
- Identification of the animals in the field was over sub-Saharan African, is also host to other arenaviruses based on external morphology and later confirmed geneti- such as the Mopeia virus in southeastern Africa ( 6 ), Moro- cally by cytochrome b gene sequencing. (cdc.gov)
- Herein we show that the nucleoprotein (NP) of arenaviruses enters the mitochondria of infected cells , affecting the mitochondrial morphology. (bvsalud.org)
Rodent5
- While rodent hosts are chronically infected with an arenavirus, they do not appear to become ill. (cdc.gov)
- Arenaviruses are shed into the environment in the urine, saliva, or droppings of infected rodent hosts. (cdc.gov)
- Banerjee C, Allen LJ, Salazar-Bravo J. Models for an arenavirus infection in a rodent population: consequences of horizontal, vertical and sexual transmission. (medscape.com)
- Detection of LASV in 2 mitochondrial demic in the western and eastern areas ( 2 ), Nigeria pres- phylogroupsoftherodentneartheNigerandBenueRivers inNigeriaunderlinesthepotentialforLASVemergencein ents an excellent opportunity for investigation of patterns fresh phylogroups of this rodent.A Mobala-like sequence of LASV and arenavirus occurrence in 2 phylogroups of wasalsodetectedineasternNigeria. (cdc.gov)
- A species of ARENAVIRUS, one of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing a fatal infection in the cricetine rodent Oryzomys albigularis. (lookformedical.com)
LCMV3
- Lymphocytic choriomeningitis virus (LCMV) was the first arenavirus identified. (cdc.gov)
- LCMV, classified as an Old World arenavirus, is the only arenavirus found in both the Western and Eastern Hemisphere. (cdc.gov)
- Brian Amman] LCMV is a rodentborne arenavirus that's endemic in the common house mouse. (cdc.gov)
Antigenic2
- Antigenic properties of the arenaviruses. (nih.gov)
- It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution. (lookformedical.com)
Infection2
- There are some arenaviruses - both New and Old World - that have been identified in host animals, but no human infection has been reported yet. (cdc.gov)
- The type species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), producing a silent infection in house and laboratory mice. (lookformedical.com)
Reveals1
- A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that JunÃn Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). (medscape.com)
World2
- In some areas of the world, arenavirus infections in people are relatively common and can cause severe disease. (cdc.gov)
- Sarute N, Ross SR. New World Arenavirus Biology. (medscape.com)
Study1
- Altogether, this study gives further inside into the endocytic pathway utilized by the arenavirus JUNV. (elsevier.com)
Cells1
- Transfer of arenavirus- or protein-specific CD8 + T cells or NK cells reduced the mortality and morbidity rates of mice highly susceptible to TB in an IFN-γ-dependent manner. (jci.org)
Mastomys3
- Phylogenetic analysis of cytochrome b (900 nt) of arenaviruses from Mastomys natalensis rodents caught in the 8 localities in Nigeria, compared to those already described in Benin and in Cameroun. (cdc.gov)
- To investigate arenavirus in Zambia, we characterized virus from the kidneys of 5 arenavirus RNA-positive rodents (Mastomys natalensis) among 263 captured. (nih.gov)
- The natural reservoir of arenavirus in Africa is rodents of the family Muridae, especially Mastomys natalensis, and nonpathogenic arenaviruses have been found in areas surrounding Zambia ( 2 - 5 ). (cdc.gov)
Lujo2
- Genetic detection and characterization of lujo virus, a new hemorrhagic Fever-associated arenavirus from southern Africa. (medscape.com)
- However, during September-October 2008, 5 hemorrhagic fever cases caused by a novel arenavirus named Lujo virus occurred in South Africa ( 1 ). (cdc.gov)
Africa1
- Arenavirus, a bisegmented ambisense single-stranded RNA virus, is 1 of the viral pathogens responsible for hemorrhagic fever in Africa and South America. (cdc.gov)
Zambia1
- Detection of increasing viral RNA by 1-step reverse transcription PCR in a novel arenavirus, Zambia, 2009. (nih.gov)
Infections3
- Clinically used in combination with interferon for hepatitis C, as aerosol for respiratory syncytial virus, and as potential prophylaxis and/or treatment of Congo-Crimean hemorrhagic fever, hantavirus infections, and Arenavirus hemorrhagic fevers. (medscape.com)
- Pasquato A, Kunz S. Novel drug discovery approaches for treating arenavirus infections. (medscape.com)
- In some areas of the world, arenavirus infections in people are relatively common and can cause severe disease. (cdc.gov)
Infection1
- There are some arenaviruses - both New and Old World - that have been identified in host animals, but no human infection has been reported yet. (cdc.gov)
Diversity1
- Until now, no structure model existed for any virus in the arenavirus family because of the instability and diversity of the GPC protein. (nih.gov)
Virus2
- A Map of the Arenavirus Nucleoprotein-Host Protein Interactome Reveals that JunÃn Virus Selectively Impairs the Antiviral Activity of Double-Stranded RNA-Activated Protein Kinase (PKR). (medscape.com)
- Lymphocytic choriomeningitis virus (LCMV) was the first arenavirus identified. (cdc.gov)
