Virus diseases caused by the ARENAVIRIDAE.
A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). Infection in rodents is persistent and silent. Vertical transmission is through milk-, saliva-, or urine-borne routes. Horizontal transmission to humans, monkeys, and other animals is important.
One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. It includes JUNIN VIRUS; PICHINDE VIRUS; Amapari virus, and Machupo virus among others. They are the cause of human hemorrhagic fevers mostly in Central and South America.
The only genus in the family ARENAVIRIDAE. It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution.
Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.
A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. The disease is characterized by congestion, edema, generalized lymphadenopathy and hemorrhagic necrosis and is sometimes fatal.
A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.
An acute febrile human disease caused by the LASSA VIRUS.
A species of ARENAVIRUS, one of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing a fatal infection in the cricetine rodent Oryzomys albigularis. Asymptomatic laboratory infection in humans has been reported.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
The relationships of groups of organisms as reflected by their genetic makeup.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
The type species of the FLAVIVIRUS genus. Principal vector transmission to humans is by AEDES spp. mosquitoes.
An acute infectious disease primarily of the tropics, caused by a virus and transmitted to man by mosquitoes of the genera Aedes and Haemagogus. The severe form is characterized by fever, HEMOLYTIC JAUNDICE, and renal damage.
The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.
Vaccine used to prevent YELLOW FEVER. It consists of a live attenuated 17D strain of the YELLOW FEVER VIRUS.
A viral encephalitis caused by the St. Louis encephalitis virus (ENCEPHALITIS VIRUS, ST. LOUIS), a FLAVIVIRUS. It is transmitted to humans and other vertebrates primarily by mosquitoes of the genus CULEX. The primary animal vectors are wild birds and the disorder is endemic to the midwestern and southeastern United States. Infections may be limited to an influenza-like illness or present as an ASEPTIC MENINGITIS or ENCEPHALITIS. Clinical manifestations of the encephalitic presentation may include SEIZURES, lethargy, MYOCLONUS, focal neurologic signs, COMA, and DEATH. (From Adams et al., Principles of Neurology, 6th ed, p750)
A species of FLAVIVIRUS, one of the Japanese encephalitis virus group (ENCEPHALITIS VIRUSES, JAPANESE), which is the etiologic agent of ST. LOUIS ENCEPHALITIS in the United States, the Caribbean, and Central and South America.
Cytoplasmic hyaline inclusions in HEPATOCYTES. They are associated with ALCOHOLIC STEATOHEPATITIS and non-alcoholic STEATOHEPATITIS, but are also present in benign and malignant hepatocellular neoplasms, and metabolic, toxic, and chronic cholestatic LIVER DISEASES.
Pathological processes involving the integrity of blood circulation. Hemostasis depends on the integrity of BLOOD VESSELS, blood fluidity, and BLOOD COAGULATION. Majority of the hemostatic disorders are caused by disruption of the normal interaction between the VASCULAR ENDOTHELIUM, the plasma proteins (including BLOOD COAGULATION FACTORS), and PLATELETS.
A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
One of two groups of viruses in the ARENAVIRUS genus and considered part of the Old World complex. It includes LASSA VIRUS and LYMPHOCYTIC CHORIOMENINGITIS VIRUS, although the latter has worldwide distribution now.
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
Membrane glycoproteins from influenza viruses which are involved in hemagglutination, virus attachment, and envelope fusion. Fourteen distinct subtypes of HA glycoproteins and nine of NA glycoproteins have been identified from INFLUENZA A VIRUS; no subtypes have been identified for Influenza B or Influenza C viruses.
Specific hemagglutinin subtypes encoded by VIRUSES.
Vaccines or candidate vaccines used to prevent infection with SALMONELLA. This includes vaccines used to prevent TYPHOID FEVER or PARATYPHOID FEVER; (TYPHOID-PARATYPHOID VACCINES), and vaccines used to prevent nontyphoid salmonellosis.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The type species of the genus INFLUENZAVIRUS A that causes influenza and other diseases in humans and animals. Antigenic variation occurs frequently between strains, allowing classification into subtypes and variants. Transmission is usually by aerosol (human and most non-aquatic hosts) or waterborne (ducks). Infected birds shed the virus in their saliva, nasal secretions, and feces.
Agents that cause agglutination of red blood cells. They include antibodies, blood group antigens, lectins, autoimmune factors, bacterial, viral, or parasitic blood agglutinins, etc.
Infections with viruses of the genus HANTAVIRUS. This is associated with at least four clinical syndromes: HEMORRHAGIC FEVER WITH RENAL SYNDROME caused by viruses of the Hantaan group; a milder form of HFRS caused by SEOUL VIRUS; nephropathia epidemica caused by PUUMALA VIRUS; and HANTAVIRUS PULMONARY SYNDROME caused by SIN NOMBRE VIRUS.
A genus of the family BUNYAVIRIDAE causing HANTAVIRUS INFECTIONS, first identified during the Korean war. Infection is found primarily in rodents and humans. Transmission does not appear to involve arthropods. HANTAAN VIRUS is the type species.
A species of HANTAVIRUS causing nephropathia epidemica, a mild form of HEMORRHAGIC FEVER WITH RENAL SYNDROME. It is found in most of Europe and especially in Finland, along with its carrier rodent, the bank vole (Clethrionomys glareolus).
Acute respiratory illness in humans caused by the Muerto Canyon virus whose primary rodent reservoir is the deer mouse Peromyscus maniculatus. First identified in the southwestern United States, this syndrome is characterized most commonly by fever, myalgias, headache, cough, and rapid respiratory failure.
An acute febrile disease occurring predominately in Asia. It is characterized by fever, prostration, vomiting, hemorrhagic phenonema, shock, and renal failure. It is caused by any one of several closely related species of the genus Hantavirus. The most severe form is caused by HANTAAN VIRUS whose natural host is the rodent Apodemus agrarius. Milder forms are caused by SEOUL VIRUS and transmitted by the rodents Rattus rattus and R. norvegicus, and the PUUMALA VIRUS with transmission by Clethrionomys galreolus.
The type species of the genus HANTAVIRUS infecting the rodent Apodemus agrarius and humans who come in contact with it. It causes syndromes of hemorrhagic fever associated with vascular and especially renal pathology.
Diseases of rodents of the order RODENTIA. This term includes diseases of Sciuridae (squirrels), Geomyidae (gophers), Heteromyidae (pouched mice), Castoridae (beavers), Cricetidae (rats and mice), Muridae (Old World rats and mice), Erethizontidae (porcupines), and Caviidae (guinea pigs).
A type of extracellular vesicle, containing RNA and proteins, that is secreted into the extracellular space by EXOCYTOSIS when MULTIVESICULAR BODIES fuse with the PLASMA MEMBRANE.
A species of the CORONAVIRUS genus causing hepatitis in mice. Four strains have been identified as MHV 1, MHV 2, MHV 3, and MHV 4 (also known as MHV-JHM, which is neurotropic and causes disseminated encephalomyelitis with demyelination as well as focal liver necrosis).
INFLAMMATION of the LIVER in animals due to viral infection.
A genus of Sciuridae consisting of 14 species. They are shortlegged, burrowing rodents which hibernate in winter.
Any of the viruses that cause inflammation of the liver. They include both DNA and RNA viruses as well viruses from humans and animals.
An ORTHOHEPADNAVIRUS causing chronic liver disease and hepatocellular carcinoma in woodchucks. It closely resembles the human hepatitis B virus.
INFLAMMATION of the LIVER in humans caused by a member of the ORTHOHEPADNAVIRUS genus, HEPATITIS B VIRUS. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.
An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.
A genus in the family FILOVIRIDAE consisting of one species (Lake Victoria marburgvirus) with several strains. The genus shows no antigenic cross-reactivity with EBOLAVIRUS.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.

Clinical case definitions for Argentine hemorrhagic fever. (1/248)

Argentine hemorrhagic fever (AHF) is a potentially lethal infection in Argentina. The case-fatality ratio is >15%, but treatment reduces the mortality rate to <1%. Diagnosis is based on clinical and laboratory criteria, but no case definition has been validated. A chart review was conducted for patients hospitalized with suspected AHF. Individuals with a fourfold rise in antibody titer were classified as cases. The combination of a platelet count of <100,000/mm3 and a white blood cell (WBC) count of <2,500/mm3 had a sensitivity and specificity of 87% and 88%, respectively, thus suggesting that the use of these criteria in a case definition would be helpful for epidemiological studies of AHF. The combination of a platelet count of <100,000/mm3 and a WBC count of <4,000/mm3 had a sensitivity of 100% and a specificity of 71%; the use of these criteria in a case definition should be helpful for screening patients for therapy with immune plasma in the region where AHF is endemic.  (+info)

Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-alpha gene expression. (2/248)

Cells of the mononuclear and endothelial lineages are targets for viruses which cause hemorrhagic fevers (HF) such as the filoviruses Marburg and Ebola, and the arenaviruses Lassa and Junin. A recent model of Marburg HF pathogenesis proposes that virus directly causes endothelial cell damage and macrophage release of TNF-alpha which increases the permeability of endothelial monolayers [Feldmann et al. , 1996]. We show that Lassa virus replicates in human monocytes/macrophages and endothelial cells without damaging them. Human endothelial cells (HUVEC) are highly susceptible to infection by both Lassa and Mopeia (a non-pathogenic Lassa-related arenavirus). Whereas monocytes must differentiate into macrophages before supporting even low level production of these viruses, the virus yields in the culture medium of infected HUVEC cells reach more than 7 log10 PFU/ml without cellular damage. In contrast to filovirus, Lassa virus replication in monocytes/macrophages fails to stimulate TNF-alpha gene expression and even down-regulates LPS-stimulated TNF-alpha mRNA synthesis. The expression of IL-8, a prototypic proinflammatory CXC chemokine, was also suppressed in Lassa virus infected monocytes/macrophages and HUVEC on both the protein and mRNA levels. This contrasts with Mopeia virus infection of HUVEC in which neither IL-8 mRNA nor protein are reduced. The cumulative down-regulation of TNF-alpha and IL-8 expression could explain the absence of inflammatory and effective immune responses in severe cases of Lassa HF.  (+info)

Fatal illnesses associated with a new world arenavirus--California, 1999-2000. (3/248)

The California Department of Health Services (CDHS) and the University of Texas Medical Branch (UTMB) recently identified evidence of infection with an arenavirus in three patients hospitalized with similar fatal illnesses. This report summarizes the investigation of these cases.  (+info)

Arenavirus antibody in rodents indigenous to coastal southern California. (4/248)

The purpose of this study was to extend our knowledge on the geographic and natural rodent host ranges of New World arenaviruses in California. Sera from 1,094 sigmodontine and 112 murine rodents were tested for antibody against Whitewater Arroyo and Amapari viruses. Antibody was found in 55 (4.6%) of the 1,206 rodents: 4 from northwestern San Diego County, 3 from Los Angeles County, and 48 from Orange County. The antibody-positive rodents included 8 (7.8%) of 103 Neotoma fuscipes, 1 (0.6%) of 180 Neotoma lepida, 1 (3.1%) of 32 Peromyscus boylii, 8 (11.0%) of 73 Peromyscus californicus, 1 (1.2%) of 85 Peromyscus eremicus, 30 (8.5%) of 353 Peromyscus maniculatus, and 6 (2.2%) of 268 Reithrodontomys megalotis. This study provides the first evidence that New World arenaviruses occur in Los Angeles and Orange counties and northwestern San Diego County, and the first evidence that Peromyscus and Reithrodontomys species are naturally infected with New World arenaviruses.  (+info)

Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae). (5/248)

The Whitewater Arroyo virus (WWA) is a newly described North American arenavirus. The purpose of this study was to elucidate the biology of this virus in its natural rodent host, Neotoma albigula (white-throated woodrat). Thirteen adult, 7 juvenile, and 8 newborn woodrats each were inoculated subcutaneously with 1,000 cell culture infectious dose50 of the WWA virus prototype strain AV 9310135. All 28 animals became infected (as measured by the recovery of infectious virus and/or seroconversion) and no overt illness was associated with infection. Infection and virus shedding in the adult animals were transient (less than 59 days) whereas virus shedding in animals inoculated at birth persisted through 164 days of age. These results indicate that the duration of WWA virus infection in N. albigula is dependent upon the animal's age at the onset of infection and that neonatal infection can result in chronic (perhaps lifelong) virus shedding.  (+info)

Distinct CD8 T cell functions mediate susceptibility to histoplasmosis during chronic viral infection. (6/248)

It has long been recognized that some viral infections result in generalized immune suppression. In acute infections, this period of suppressed immunity is relatively short. However, chronic infections associated with a prolonged period of immune suppression present far greater risks. Here, we examined the role of CD8 T cell responses following viral infection in immunity to systemic histoplasmosis. Although wild-type mice with systemic histoplasmosis were able to control the infection, those simultaneously infected with lymphocytic choriomeningitis virus clone 13 showed reduced immunity with greater fungal burden and high mortality. The immune suppression was associated with loss of CD4 T cells and B cells, generalized splenic atrophy, and inability to mount a granulomatous response. Removing the anti-viral CD8 T cells in the coinfected mice enabled them to reduce the fungal burden and survive the infection. Their lymphoid organs were replenished with CD4 T and B cells. In contrast to wild-type mice, perforin-deficient mice infected with lymphocytic choriomeningitis virus clone 13 and Histoplasma showed an absence of immunopathology, but the animals still died. These results show that CD8 T cells can suppress immunity through different mechanisms; although immunopathology is perforin-dependent, lethality is perforin-independent.  (+info)

Molecular analysis of the interaction of LCMV with its cellular receptor [alpha]-dystroglycan. (7/248)

alpha-Dystroglycan (DG) has been identified as the cellular receptor for lymphocytic choriomeningitis virus (LCMV) and Lassa fever virus (LFV). This subunit of DG is a highly versatile cell surface molecule that provides a molecular link between the extracellular matrix (ECM) and a beta-DG transmembrane component, which interacts with the actin-based cytoskeleton. In addition, DG exhibits a complex pattern of interaction with a wide variety of ECM and cellular proteins. In the present study, we characterized the binding of LCMV to alpha-DG and addressed the role of alpha-DG-associated host-derived proteins in virus infection. We found that the COOH-terminal region of alpha-DG's first globular domain and the NH2-terminal region of the mucin-related structures of alpha-DG together form the binding site for LCMV. The virus-alpha-DG binding unlike ECM alpha-DG interactions was not dependent on divalent cations. Despite such differences in binding, LCMV and laminin-1 use, in part, an overlapping binding site on alpha-DG, and the ability of an LCMV isolate to compete with laminin-1 for receptor binding is determined by its binding affinity to alpha-DG. This competition of the virus with ECM molecules for receptor binding likely explains the recently found correlation between the affinity of LCMV binding to alpha-DG, tissue tropism, and pathological potential. LCMV strains and variants with high binding affinity to alpha-DG but not low affinity binders are able to infect CD11c+ dendritic cells, which express alpha-DG at their surface. Infection followed by dysfunction of these antigen-presenting cells contributes to immunosuppression and persistent viral infection in vivo.  (+info)

Role of CD28-B7 interactions in generation and maintenance of CD8 T cell memory. (8/248)

Although the role of CD28-B7 interaction in the activation of naive T cells is well established, its importance in the generation and maintenance of T cell memory is not well understood. In this study, we examined the requirement for CD28-B7 interactions in primary T cell activation and immune memory. Ag-specific CD8 T cell responses were compared between wild-type (+/+) and CD28-deficient (CD28(-/-)) mice following an acute infection with lymphocytic choriomeningitis virus (LCMV). During the primary response, there was a substantial activation and expansion of LCMV-specific CD8 T cells in both +/+ and CD28(-/-) mice. However, the magnitude of the primary CD8 T cell response to both dominant and subdominant LCMV CTL epitopes was approximately 2- to 3-fold lower in CD28(-/-) mice compared with +/+ mice; the lack of CD28-mediated costimulation did not lead to preferential suppression of CD8 T cell responses to the weaker subdominant epitopes. As seen in CD28(-/-) mice, blockade of B7-mediated costimulation by CTLA4-Ig treatment of +/+ mice also resulted in a 2-fold reduction in the anti-LCMV CD8 T cell responses. Loss of CD28/B7 interactions did not significantly affect the generation and maintenance of CD8 T cell memory; the magnitude of CD8 T cell memory was approximately 2-fold lower in CD28(-/-) mice as compared with +/+ mice. Further, in CD28(-/-) mice, LCMV-specific memory CD8 T cells showed normal homeostatic proliferation in vivo and also conferred protective immunity. Therefore, CD28 signaling is not necessary for the proliferative renewal and maintenance of memory CD8 T cells.  (+info)

Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean?
The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. PLoS Pathog. 2010 Sep 16; 6(9):e1001038 ...
Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. The majority of these viruses are rodent-borne and the arenavirus family can be divided into two groups: the Lassa-Lymphocytic choriomeningitis serocomplex and the Tacaribe serocomplex. Arenavirus-induced disease may include characteristic symptoms ranging from fever, malaise, body aches, petechiae, dehydration, hemorrhage, organ failure, shock, and in severe cases death. Currently, there are few prophylactic and therapeutic treatments available for arenavirus-induced symptoms. Supportive care and ribavirin remain the predominant strategies for treating most of the arenavirus-induced diseases. Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. Because of the potential for person-to-person spread, the ability to cause lethal or debilitating disease in humans,
Lymphocytic choriomeningitis virus (LCMV) is a single-stranded RNA virus that belongs to the family Arenaviridae (so named because of its appearance on electron microscopy, which resembles grains of sand). Other members of this family include Lassa virus and the Tacaribe group.
Persistent viral infections can interfere with FcγR-mediated antibody effector functions by excessive immune complex (IC) formation, resulting in resistance to therapeutic FcγR-dependent antibodies. We and others have previously demonstrated that mice persistently infected with lymphocytic choriomeningitis virus (LCMV) are resistant to a wide range of depleting antibodies due to excessive IC formation. Here, we dissect the mechanisms by which two depleting antibodies overcome the obstacle of endogenous ICs and achieve efficient target cell depletion in persistently infected mice. Efficient antibody-mediated depletion during persistent LCMV infection required increased levels of antibody bound to target cells or use of afucosylated antibodies with increased affinity for FcγRs. Antibodies targeting the highly expressed CD90 antigen or overexpressed human CD20 efficiently depleted their target cells in naïve and persistently infected mice, whereas antibodies directed against less abundant ...
Lymphocytic Choriomeningitis (LCM) Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae that was initially isolated in 1933. The primary host of LCMV is the common house mouse, Mus musculus. Infection in house mouse populations may vary by geographic location, though it is estimated that 5% of house mice throughout the United States carry LCMV and are able to transmit virus for the duration of their lives without showing any sign of illness. Other types of rodents, such as hamsters, are not the natural reservoirs but can become infected with LCMV from wild mice at the breeder, in the pet store, or home environment. Humans are more likely to contract LCMV from house mice, but infections from pet rodents have also been reported.. LCMV infections have been reported in Europe, the Americas, Australia, and Japan, and may occur wherever infected rodent hosts of the virus are found. The ...
Goldsmith, Cynthia S.; Ksiazek, Thomas G.; Rollin, Pierre E.; Comer, James A.; Nicholson, William L.; Peret, Teresa C.T.; Erdman, Dean D.; Bellini, William J.; Harcourt, Brian H.; Rota, Paul A.; Bhatnagar, Julu; Bowen, Michael D.; Erickson, Bobbie R.; McMullan, Laura K.; Nichol, Stuart T.; Shieh, Wun-Ju; Paddock, Christopher D.; Zaki, Sherif R ...
In Vivo Selection of a Lymphocytic Choriomeningitis Virus Variant That Affects Recognition of the GP33-43 Epitope by H-2Db but Not H-2Kb ...
books.google.comhttps://books.google.com/books/about/Immunobiology_and_pathogenesis_of_persis.html?id=O9eAAAAAIAAJ&utm_source=gb-gplus-shareImmunobiology and pathogenesis of persistent virus infections ...
2018 - Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018 - Maes P., Alkhovsky S.V., Bao Y., Beer M., Birkhead M., Briese T., Buchmeier M.J., Calisher C.H., Charrel R.N., Choi I.R., Clegg C.S., de la Torre J.C., Delwart E., DeRisi J.L., Di Bello P.L., Di Serio F., Digiaro M., Dolja V.V., Drosten C., Druciarek T.Z., Du J., Ebihara H., Elbeaino T., Gergerich R.C., Gillis A.N., Gonzalez J.-P.J., Haenni A.-L., Hepojoki J., Hetzel U., Ho T., Hong N., Jain R.K., Jansen van Vuren P., Jin Q., Jonson M.G., Junglen S., Keller K.E., Kemp A., Kipar A., Kondov N.O., Koonin E.V., Kormelink R., Korzyukov Y., Krupovic M., Lambert A.J., Laney A.G., LeBreton M., Lukashevich I.S., Marklewitz M., Markotter W., Martelli G.P., Martin R.R., Mielke-Ehret N., Muhlbach H.-P., Navarro B., Ng T.F.F., Nunes M.R.T., Palacios G., Paweska J.T., Peters C.J., Plyusnin A., Radoshitzky S.R., Romanowski V., Salmenpera P., Salvato M.S., Sanfacon H., Sasaya T., Schmaljohn C., Schneider B.S., Shirako Y., ...
Lymphocytic choriomeningitis: Lymphocytic choriomeningitis, inflammation of the meninges (membranes covering the central nervous system) and choroid plexus (an area of the brain that regulates the
Browse our Cardiology doctors in Arroyo Grande, CA. Call or book online to schedule an appointment with one of our Arroyo Grande specialists today.
Scandal ridden former councilmember Ed Arnold stepped down to allow the Arroyo Grande City Council to avoid distraction related to his personal life, and at his replacements first council meeting, questions about her lifestyle started a confrontation between her supporters and her critics. Public comment about recently appointed Arroyo Grande Councilwoman Karen Rays, activities with the SLO Hash House Harriers brought a moment of stunned silence to tonights City Council meeting.
I wrote a couple of months ago about the burgeoning Arroyo Food Co-Op. It would be a locally owned and operated operation combining the best of the local-foods movement, the slow-food movement, the fun and tasty farmers markets that are so popular in so many of our cities, Jones Coffee and Europane, Trader Joes and Whole Foods. Then I sort of forgot about it. But running on an Upper Arroyo trail the other morning, Pasadenan Mia Dunn dashed downhill past me, made some remarks about what a good-looking dog I was out with - complimenting Charlie is always a good way to get to me - and said that the Co-Op is going great guns. Its still early days for the homegrown community market that would serve the Pasadena area. Theres no bricks and mortar up yet in which to shop for heirloom nectarines. But a board of directors has been elected, and Patrick Reagan was elected chair of that. The board is having a meeting Thursday night - tomorrow - at 7 p.m. at 33 S. Catalina Ave., No. 104, Pasadena, and ...
Persistierende virale Infektionen wie z.B. Hepatitis C und HIV stellen wegen des Trägertums durch Tiere oder Menschen ein Virus-Reservoir dar, welches eine zunehmende Gesundheitsbedrohung bedeutet. Besonders im Bereich der Impfung, aber ebenso hinsichtlich Therapie der Infektion selbst und ihrer Langzeitkomplikationen, sind die Erfolge bescheiden oder unzureichend. Geläufige Konzepte und ...
JPT Peptide Technologies is a DIN ISO 9001:2015 certified and GCLP compliant integrated provider of innovative peptide based catalog products and custom services.
A small mouse stock in which lymphocytic choriomeningitis is endemic has been observed over a period of 4 years. The disease has persisted during that time, but it has become so mild that it can no longer be recognized by clinical observation. In spite of this fact, all of the stock mice tested, both young and old, carried considerable amounts of virus in their organs and blood. The females readily transmit the infection to their offspring. Intrauterine infection has become the only mode of transmission of the disease in contrast to the situation in 1935 when a certain number of mice were born virus-free and became infected by contact shortly after birth.. The present mildness of the disease appears to be due to two factors, namely, the change in its mode of transmission just mentioned, and a shift in the severity of the disease with regard to the age of the host at the time of infection. This shift has occurred gradually since 1935 when the mice infected in utero were the only ones to become ...
Order this unique deal on the Honeywell VRN2AJ3S2B Modg Picv 1/2 Inch Npt 7 0 Gpm here with the PlumbersStock store - quality Honeywell supply.
Mice, Antigens, Cell, Cells, T Cells, Virus, Hepatitis, Hepatitis C, Iodine, Acids, Cytotoxic T Lymphocytes, Fatty Acids, Immunity, Infections, Liposomes, Lymphocytes, Lymphocytic Choriomeningitis, Lymphocytic Choriomeningitis Virus, Memory, Peptides
This 1 light Outdoor Wall Mount from the Himeji collection by Arroyo Craftsman will enhance your home with a perfect mix of form and function. The features include a Verdigris Patina finish applied by experts. This item qualifies for free shipping! Check the right-hand bar or call our dedicated Sales Team for similar items and additional options not pictured.
This 1 light Post Mount from the Berkeley collection by Arroyo Craftsman will enhance your home with a perfect mix of form and function. The features include a Mission Brown finish applied by experts. This item qualifies for free shipping! Check the right-hand bar or call our dedicated Sales Team for similar items and additional options not pictured.
USGS National Water Census Water Budget Data Resources for the Sand Arroyo - HUC 11040004 (Turn off compatibility view settings in IE if having problems viewing this site) ...
President Rodrigo Duterte said he was considering naming former president and Pampanga Rep. Gloria Arroyo to a body that will propose changes to the 1987 Constitution.
That said, Arroyo was a sensational apprentice at Suffolk Downs and went on to great success on the NYRA circuit before his issues began to catch up with him. He was from Somerville, Mass., a suburb of Boston. I recall sitting in the simulcast area at Suffolk one weekend and getting into a conversation with a man who told me he knew Arroyo quite well -- he was the assistant principal (or some similar title) at Somerville High School when Arroyo was a student there. He spent a lot of time in my office, he told me. Anyone familiar with the traditional duties of an assistant principal knows what that means ...
In case you have mice, hamsters, etc. as pets you need to be careful of a virus called Lymphocytic choriomeningitis virus (LMCV) They can cause birth defects or miscarriages. Try keeping them in a separate part of the house. Most definitely wash your hands with soap and water after touching them. Keep pet rodents away from your face ...
RN [1] RM PMID:20862324 RT The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. RA Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B RL PLoS Pathog. 2010 Sep 16;6(9):e1001038 ...
Several viruses in the Arenaviridae family infect humans and cause severe hemorrhagic fevers which lead to high case fatality rates. Due to their pathogenicity and geographic tropisms, these viruses remain very understudied. As a result, an effective vaccine or therapy is urgently needed. Here, we describe efforts to produce cross-reactive monoclonal antibodies that bind to both New and Old World arenaviruses. All of our MAbs seem to be nonneutralizing and nonprotective and target subunit 2 of the glycoprotein. Due to the lack of reagents such as recombinant glycoproteins and antibodies for rapid detection assays, our MAbs could be beneficial as analytic and diagnostic tools.
Looking for online definition of lymphocytic choriomeningitis in the Medical Dictionary? lymphocytic choriomeningitis explanation free. What is lymphocytic choriomeningitis? Meaning of lymphocytic choriomeningitis medical term. What does lymphocytic choriomeningitis mean?
Michael B.A. Oldstone is a Professor in the Department of Immunology & Microbial Science at The Scripps Research Institute where he heads the Viral-Immunobiology Laboratory. He focuses on viral-host interactions, especially how viruses cause disease. His work studying the prototype arenavirus lymphocytic choriomeningitis virus dissected the biologic and molecular parameters of how virus infection leads to the submission or the enhancement of the immune response. Submission or subversion leads to viral persistence and enhancement to autoimmunity and immunopathology. Using experimental animal model systems, his findings, especially with virus-specific cytotoxic T cells, with molecules that negatively regulate such cytotoxic T cells and with formation and consequences of viral antibody immune complexes, have been extended to infectious diseases of humans. These paradigm observations, coupled with his work on viral variants and dendritic cell interactions have led to his election to the National ...
Analyses with segmental reassortants of lymphocytic choriomeningitis virus (LCMV) RNA have shown that cytotoxic T lymphocytes (CTL) are induced by and recognize proteins encoded by the viral short segment, which specifies two virus structural proteins, glycoprotein (GP) and nucleoprotein (NP). Expression of cDNA copies of these genes in vaccinia virus vectors demonstrates that C57BL/6 (H2bb) mice mount significant CTL responses to both GP and NP. We have used LCMV-specific H2bb-restricted CTL clones and a family of serial C-terminal truncations of the LCMV GP expressed in vaccinia virus to map the precise specificities of the anti-GP clones. Of the 18 CTL clones studied, 1 recognizes NP and the other 17 recognize GP. The reactivities of 14 of the 17 anti-GP CTL clones against the deleted GP molecules have been fully characterized, and two clear patterns of anti-GP activity have emerged, defining at least two CTL epitopes. The first epitope, recognized by only two of the clones, lies within GP ...
Isolates of lymphocytic choriomeningitis virus (LCMV) that elicit a cytotoxic T-lymphocyte response (CTL+) have been compared with isolates that suppress the CTL response (CTL-) in an effort to map this phenotype. A single amino acid change in the glycoprotein of the LCMV Armstrong (ARM) strain is consistently associated with the CTL- trait and the ability of the virus to persist (P+). The CTL+ P- parental strain spontaneously gives rise to CTL- P+ variants within lymphoid tissues of mice persistently infected from birth. To map the structural basis of the phenotype, the complete RNA sequence of LCMV ARM 53b (CTL+) was compared with that of its variant ARM clone 13 (CTL-). Differences in 5 of 10,600 nucleotides were found. Three changes are noted in the large L RNA segment, and two are noted in the small S RNA segment. Only two of the changes distinguishing CTL+ from CTL- isolates affect amino acid coding: lysine to glutamine at amino acid 1079 of the polymerase protein, and phenylalanine to ...
Persistent infection of C3H/St mice with certain strains of lymphocytic choriomeningitis virus (LCMV) causes a growth hormone (GH) deficiency syndrome (GHDS) manifested as growth retardation and hypoglycemia. Infected mice show high levels of viral replication in the GH-producing cells in the anterior pituitary leading to decreased synthesis of GH mRNA and protein despite the absence of detectable virus-induced cell structural damage. Virus clones isolated from the GHDS-negative LCMV WE strain can cause the disease, while others cannot. The genetic basis of this phenotypic difference is a nucleotide substitution resulting in a single amino acid difference in the viral glycoprotein. Reassortant studies indicate that the single amino acid substitution (Ser-153 to Phe) is sufficient to allow infection of the GH-producing cells and cause GHDS. These results show that a single change in the genome can affect viral pathogenicity by altering the tropism of the virus.
The main reservoir of LCMV, which belongs to the arenaviruses, is the house mouse. Cells infected with LCMV express antigens and are recognised by cytotoxic T lymphocytes. This lymphocyte activity also makes the blood-brain barrier permeable resulting in meninges and neurons being damaged. Infection of adult mice leads to choriomeningitis. In contrast, an intrauterine or neonatal infection generally causes an asymptomatic chronic carrier state in mice, with such animals forming immune complexes in the course of their lifetime that lead to glomerulonephritis. In guinea pigs and hamsters, LCMV infections often progress subclinically, however, conjunctivitis, blepharitis, respiratory symptoms, tremor, seizures and paralysis have been described. LCMV is transmitted diaplacentally and with all secretions and excretions. In humans, LCMV rarely leads to choriomeningitis; the infection is usually asymptomatic or shows mild, flu-like symptoms. An infection in the second part of pregnancy can cause severe ...
THE interaction of lymphocytic choriomeningitis (LCM) virus with mouse tissues has been discussed recently1-5. The fulminating disease, which occurs in adult mice after intracerebral inoculation with LCM virus, can be ameliorated by several treatments known to impair the immune response of the host, such as X-rays6, amethopterin7, thymectomy8 and anti-lymphocyte serum9. The pathology of the disease10 supports the current view that an immune reaction by the host against the virus or a virus product, located in or on infected cells, plays an essential part in its pathogenesis. A similar mechanism may be important in the chronic autoimmune-like disease in virus carrier mice2,5. Further elucidation of this disease mechanism depends on understanding the nature of the immune response and its target. A question of considerable interest is what the consequences might be for virus infected cells in the event of an immune response against the virus or a virus product. Here we report preliminary experiments
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Participate in a whitewater trip using either a canoe or kayak on a Class I or Class II river. Help to prepare a written plan, specifying the route, schedule, equipment, safety precautions, and emergency procedures. Determine local rules and obtain permission from landowners and land managers in advance. Explain what steps you have taken to comply with BSA Safety Afloat and the American Whitewater safety guidelines. Execute the plan with others ...
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What is the difference between Latent and Persistent Viral Infection? Clinical features are present only during persistent stage of viral infection. In latent..
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Dendritic cells (DCs) comprise the major antigen-presenting cells (APCs) of the host, uniquely programmed to stimulate immunologically naïve T lymphocytes. Viruses that can target and disorder the...
The primary finding of this study was the emergence of a distinct A-to-G/U-to-C hypermutation pattern in the single-stranded RNA genome of LCMV both in cell culture and in the organs of infected mice. This pattern is probably due to unspecific deamination by ADAR1-L, which was found to be upregulated during infection of cells and mice with LCMV. Furthermore, these A-to-G mutations lead to a high percentage of nonfunctional viral protein, thereby weakening viral fitness.. The A-to-G hypermutation pattern observed in this study was most likely attributed to RNA editing and not to errors of the viral polymerase. The hypermutation pattern was not observed 2 days after infection in L929 cells. In mice at days 5 and 8 p.i., the dominance of A-to-G mutations is also reduced compared to that at day 4, which is consistent with lower ADAR1-L expression at these time points. Furthermore, although viral RNA polymerases lack 3′-to-5′ proofreading activity, they have never been reported to exhibit a ...
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(a) Schematic view of acute and chronic LCMV infections including virus and cytotoxic T lymphocyte (CTL) dynamics. (b) Representation of the CTL-induced immunop
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Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa ... After the first infection, macrophages display antibodies on their cell membranes specific to the dengue virus. By attaching to ... The family Arenaviridae include the viruses responsible for Lassa fever (Lassa virus), Lujo virus, Argentine (Junin virus), ... The order Bunyavirales includes the families Arenaviridae, Filoviridae, and all members of the former family Bunyaviridae, ...
"Methods for treating arenaviridae and coronaviridae virus infections", published 16 March 2017, issued 9 April 2019, assigned ... and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection ... but was then repurposed and studied as a potential treatment for Ebola virus disease and Marburg virus infections. According to ... "Methods for treating Filoviridae virus infections", published 5 May 2016, issued 8 August 2017, assigned to Gilead Sciences Inc ...
in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ... An outbreak of Chapare mammarenavirus infection occurred in the village of Samuzabeti, Chapare Province, Bolivia, in January ... 2 July 2014). "Rename one (1) genus and twenty-five (25) species in the family Arenaviridae" (PDF). International Committee on ... Chapare mammarenavirus is a virus from the family Arenaviridae and causes hemorrhagic fever (Chapare hemorrhagic fever). ...
Those infections that proved fatal caused death within 10-13 days of showing symptoms. All four patients in which infection ... Viruses from the Arenaviridae family, to which Lujo virus belongs, almost always have a rodent reservoir, with one virus in the ... In four cases (80% of total known infections) the infection was fatal. The fifth case was treated with ribavirin early after ... Lujo is a bisegmented RNA virus-a member of the family Arenaviridae-and a known cause of viral hemorrhagic fever (VHF) in ...
state, Infection with LCMV should be considered in the differential diagnosis of any compatible, severe viral infection or ... Viral Zone "Arenaviridae" Zhou, X; Ramachaundran, S; Mann, M; Popkin, DL (2012). "Role of Lymphocytic Choriomeningitis virus( ... Such infections are rare. To date, (January 2017) documented infections in humans have occurred only after introduction to ... Lymphocytic choriomeningitis is not a commonly reported infection in humans, though most infections are mild and are often ...
Post infection (and providing that the person survives the infection), those that have contracted BHF are usually immune to ... BHF was first identified in 1963 as an ambisense RNA virus of the Arenaviridae family, by a research group led by Karl Johnson ... The infection has a slow onset with fever, malaise, headache and myalgia, very similar to Malaria symptoms. Petechiae (blood ... and a serosurvey was conducted to determine the extent of Machupo virus infections in the Department. A SEDES expert involved ...
Research showed a twofold increase risk of infection for those living in close proximity to someone with infection symptoms ... Lassa virus is a member of the Arenaviridae, a family of negative-sense, single-stranded RNA viruses. Specifically it is an old ... The infection affects females 1.2 times more than males. The age group predominantly infected is 21-30 years. Lassa high risk ... The virus is present in urine for between three and nine weeks after infection, and it can be transmitted in semen for up to ...
As part of the trial protocol, a volunteer must have begun drug treatment in the first year of infection and have achieved 6 ... a member of the Arenaviridae family, causes severe and often fatal hemorrhagic illnesses in an overlapping region with Ebola. ... Gay and bisexual men bear the greatest burden by risk group, representing nearly 70% of new infections in the U.S. African- ... Zika Virus Zika virus infection has been linked to an increase in microcephaly in infants and Guillain-Barre syndrome (a ...
Previous cases of infection were from California. However, the virus has been found in woodrats in New Mexico and, more ... in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ... WWAV infection is associated with hemorrhagic fever with liver failure. It is often associated with a mild febrile illness, ... In addition, control of rodents near homes can help prevent infection. Rodent carcasses and materials should be double-bagged ...
Anthrax was used in a series of attacks by a microbiologist at the US Army Medical Research Institute of Infection Disease on ... and by the family Arenaviridae (for example Lassa virus and Machupo virus). Ebola virus disease, in particular, has caused high ... The weaponized threat comes mainly in the form of pneumonic plague (infection by inhalation) It was the disease that caused the ... Even a few cases of infection can disrupt a country's agricultural production and exports for months, as evidenced by FMD ...
for infection. Easily spread by aerosol.[6]p.96. Filoviridae and Arenaviridae viruses. Many. Cause viral hemorrhagic fevers, ... "MRSA Infection". Mayo Clinic. Mayo Foundation for Medical Education and Research. September 9, 2015. Retrieved February 9, 2016 ...
Lassa virus from the Arenaviridae family causes Lassa hemorrhagic fever and is also a robovirus transmitted by the rodent genus ... This process can also lead to transmission and infection. Colorado tick fever virus causes high fevers, chills, headache, ... "Experimental Colorado Tick Fever virus Infection in Colorado Mammals". The American Journal of Tropical Medicine and Hygiene. ... Roboviruses mainly belong to the virus families Arenaviridae and Hantaviridae. Like arbovirus (arthropod borne) and tibovirus ( ...
Incidence of infection is closely linked to vector activity, for example, mosquito-borne viruses are more common in the summer ... The order is organized into the following 12 families: Arenaviridae Cruliviridae Fimoviridae Hantaviridae Leishbuviridae ... Symptomatic infection typically causes non-specific flu-like symptoms with fever lasting for about three days. Because of their ... Human infections with certain members of Bunyavirales, such as Crimean-Congo hemorrhagic fever orthonairovirus, are associated ...
Arenaviridae Detailed genomic and bioinformatic information about Arenaviridae at NIH-funded database. Arenaviridae Genomes ... Humans' risk of contracting the Arenavirus infection is related to age, race, or sex within the degree of contact with the ... Within the family Arenaviridae, arenaviruses were formerly all placed in the genus Arenavirus, but in 2014 were divided into ... Clinical infections: Lassa fever is characterised by high fever, severe myalgia, coagulopathy, haemorrhagic skin rash, and ...
A viral disease (or viral infection) occurs when an organism's body is invaded by pathogenic viruses, and infectious virus ... "Arenaviridae". ViralZone. SIB Swiss Institute of Bioinformatics. Retrieved 2015-10-03. "Bunyaviridae". ViralZone. SIB Swiss ... "Babies Born with CMV (Congenital CMV Infection)". Centers for Disease Control and Prevention. April 13, 2017. Retrieved June 17 ... Page 273 in: Lennette's Laboratory Diagnosis of Viral Infections (Fourth ed.). CRC Press. 2010. ISBN 978-1420084962. Murillo A ...
Baize, S.; Kaplon, J.; Faure, C.; Pannetier, D.; Georges-Courbot, M. C.; Deubel, V. (2004). "Lassa virus infection of human ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... where the annual incidence of infection is between 300,000 and 500,000 cases, resulting in 5,000 deaths per year.[2] ...
As of 2019, there had only been four documented infections of Brazilian mammarenavirus: two occurred naturally, and the other ... 2 July 2014). "Rename one (1) genus and twenty-five (25) species in the family Arenaviridae" (PDF). International Committee on ... "Treatment of a Laboratory-Acquired Sabiá Virus Infection". N Engl J Med. 333 (5): 317-318. doi:10.1056/NEJM199508033330505. ...
Lassa virus (Arenaviridae) Lymphocytic choriomeningitis virus (Arenaviridae) Hantavirus (Bunyaviridae) Marburg virus ( ... which often aims to prevent viral infections. In modern history, numerous disease outbreaks have been caused by RdRp-encoding ...
Lassa virus (Arenaviridae) Lymphocytic choriomeningitis virus (Arenaviridae) Hantavirus (Hantaviridae) Marburg virus ( ... Jiang H, Zheng X, Wang L, Du H, Wang P, Bai X (2017). "Hantavirus infection: a global zoonotic challenge". Virol Sin. 32 (1): ... Borkenhagen LK, Salman MD, Ma MJ, Gray GC (November 2019). "Animal influenza virus infections in humans: A commentary". Int J ... Avsic-Zupanc T, Saksida A, Korva M (April 2019). "Hantavirus infections". Clin Microbiol Infect. 21S: e6-e16. doi:10.1111/1469- ...
May 17, 2007, Science Daily: Herpes infection might have an up side Citat: "...U.S. medical scientists say a herpes virus ... Arenaviridae f.eks. Lassafeber. *Poxviridae f.eks. kopper. *Retroviridae f.eks. HIV ... infection has an unexpected up side, at least in mice, since it protects them against bacterial infections..." ... Hantaviral Proteins: Structure, Functions, and Role in Hantavirus Infection. Frontiers in Microbiology ...
Arenaviridae) Lymphocytic choriomeningitis virus (Arenaviridae) Hantavirus (Bunyaviridae) Marburg Virus (Filoviridae) Ebola ... Purified RNA of a positive-sense virus can directly cause infection though it may be less infectious than the whole virus ... Kondo H, Chiba S, Toyoda K, Suzuki N (January 2013). "Evidence for negative-strand RNA virus infection in fungi". Virology. 435 ... The resulting recombinant viruses may sometimes cause an outbreak of infection in humans. Classification of the RNA viruses is ...
Quaranfil virus is the only member of the genus to have been shown to infect humans; infection generally appears to be ... I. Evidence suggesting the placement of viruses in families Arenaviridae, Paramyxoviridae, or Poxviridae". Archives of Virology ... 2006). "Index of Viruses - Arenaviridae". ICTVdB - the Universal Virus Database, Version 4. Columbia University. Archived from ...
The type-1 interferon response seems to play an important role in the host's response to chikungunya infection. Upon infection ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... "Infection of myofibers contributes to increased pathogenicity during infection with an epidemic strain of chikungunya virus". ... Chikungunya is an infection caused by the chikungunya virus (CHIKV).[3] Symptoms include fever and joint pains.[2] These ...
"An outbreak of human Semliki Forest virus infections in Central African Republic". The American Journal of Tropical Medicine ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... Only one lethal human infection has been reported. In this one case, the patient was speculated to be immunodeficient and ... "Semliki Forest virus infection of mice: A model for genetic and molecular analysis of viral pathogenicity". The Journal of ...
Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection (PDF) ... 沙状病毒科 Arenaviridae. *本雅病毒科 Bunyaviridae ... Camel infection 'led to Mers death'. BBC News. 2014-06-05 [2014 ... WHO: Novel coronavirus infection. 2013-02-11 [2013-02-13].. *^ James Gallagher. Coronavirus: Signs the new Sars-like virus can ... a person with a fever, respiratory infection, and evidence of pneumonia or acute respiratory distress syndrome. and. testing ...
C. J. Peters (December 1998). Infection Control for Viral Haemorrhagic Fevers in the African Health Care Setting (PDF). Centers ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... Weingartl HM, Nfon C, Kobinger G (May 2013). Review of Ebola virus infections in domestic animals. Dev Biol. Developments in ... Filoviral infection also interferes with proper functioning of the innate immune system.[44][46] EBOV proteins blunt the human ...
"Infection prevention and control during health care for probable or confirmed cases of novel coronavirus (nCoV) infection" (PDF ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... Middle East respiratory syndrome (MERS), also known as camel flu,[1] is a viral respiratory infection caused by the MERS- ... As of 27 June 2015, 19 people in South Korea have died from this outbreak, with 184 confirmed cases of infection.[75] There ...
As with many infections, the very young, the very old and the immunocompromised are at a higher risk of developing severe ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... after the virus was isolated from stored brain and spinal tissue of a child who died of an unknown infection in La Crosse, ... "Possible Congenital Infection with La Crosse Encephalitis Virus - West Virginia, 2006-2007". MMWR. Morbidity and Mortality ...
... (JE) is an infection of the brain caused by the Japanese encephalitis virus (JEV).[3] While most ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... The Japanese encephalitis virus (JEV) has an incubation period of 2 to 26 days.[4] The vast majority of infections are ... Infection with Japanese encephalitis confers lifelong immunity. There are currently three vaccines available: SA14-14-2, IC51 ( ...
Feline leukemia virus and Feline immunodeficiency virus infections are treated with biologics, including the only ... At that point, the infection will persist indefinitely. In most viruses, DNA is transcribed into RNA, and then RNA is ... As a result, cells such as neurons are very resistant to infection and transduction by retroviruses. This gives rise to a ... Antiretroviral drugs are medications for the treatment of infection by retroviruses, primarily HIV. Different classes of ...
Hepatis B Virus (HBV) was identified as an infection distinct from Hepatitis A through its contamination of measles, mumps, and ... Diseases associated with this family include: liver infections, such as hepatitis, hepatocellular carcinomas (chronic ... cell to infect others or are immediately dismantled so the new viral genomes can enter the nucleus and magnify the infection. ...
Breuil, G., Bonami, J.R., Pepin, J.F., and Pichot, Y. (1991). Viral infection (picorna-like virus) associated with mass ... Mechanisms of Capsid Assembly and Viral Infection. PLoS Pathogens 11(10), e1005203. ...
Without the virus infection, phagocytic hemocytes (blood cells) will encapsulate and kill the wasp egg and larvae but the ... The infection does not lead to replication of new viruses, rather it affects the caterpillar's immune system. ...
The presence of IgM in the blood of the host is used to test for acute infection, whereas IgG indicates an infection sometime ... Vaccination is a cheap and effective way of preventing infections by viruses. Vaccines were used to prevent viral infections ... Smallpox infections have been eradicated.[196] Vaccines are available to prevent over thirteen viral infections of humans,[197] ... Hepatitis viruses can develop into a chronic viral infection that leads to liver cancer.[179][180] Infection by human T- ...
The "sporadic infection" of humans is usually caused by a Hyalomma tick bite. Animals can transmit the virus to humans, but ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... "Ebola virus infection - Differentials , BMJ Best Practice". bestpractice.bmj.com. Retrieved 21 May 2018.. ... In August 2013, a farmer from Agago, Uganda was treated at Kalongo Hospital for a confirmed CCHF infection. The deaths of three ...
"Ebolavirus and Marburgvirus Infections" (PDF).. *^ a b Siegert, R.; Shu, H. L.; Slenczka, W.; Peters, D.; Müller, G. (2009). " ... Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ... He also survived the infection.[20][84]. 2008 cases[edit]. On July 10, 2008, the Netherlands National Institute for Public ... Centers for Disease Control, Infection Control for Viral Haemorrhagic Fevers In the African Health Care Setting. ...
Common infections in humans caused by members of this order include cold sores, genital herpes, chickenpox, shingles, and ...
But, unlike other viral infections, the incidence of polio - the rarer severe form of the infection - increased in the 20th ... Many bacteriologists soon discovered the cause of numerous infections. However, some infections remained, many of them ... Ivanovsky suggested the infection might be caused by a toxin produced by bacteria, but did not pursue the idea.[3] ... Infections by poliovirus most often cause the mildest of symptoms. This was not known until the virus was isolated in cultured ...
The gammaherpesviruses, including HVS, EBV, KSHV, and RRV, are capable of establishing latent infection in lymphocytes.[9] ... Ackermann, M. (2006). "Pathogenesis of gammaherpesvirus infections". Veterinary Microbiology. 113 (3-4): 211-222. doi:10.1016/j ... Viruses that establish lifelong latent infections must ensure that the viral genome is maintained within the latently infected ... Attenuated virus mutants represent a promising approach towards gamma-herpesvirus infection control. Surprisingly, latency- ...
chronic infection in adult, and acute viral disease in young salmonid fish.[1][2] ...
Browse by Outcome: Arenaviridae Infections (2 articles). % of records by year: 1965 2017 ...
What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean? ... Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. ... Arenaviridae infections , definition of Arenaviridae infections by Medical dictionary https://medical-dictionary. ... redirected from Arenaviridae infections). Also found in: Dictionary, Thesaurus. arenavirus. [ah-re´nah-vi″rus] any member of a ...
"Arenaviridae Infections" by people in this website by year, and whether "Arenaviridae Infections" was a major or minor topic of ... "Arenaviridae Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Arenaviridae Infections" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Arenaviridae Infections". ...
Pirital virus-hamster model is a very promising new small animal model for studying the pathogenesis of arenavirus infections, ... f Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral ... Pirital virus-hamster model is a very promising new small animal model for studying the pathogenesis of arenavirus infections, ...
Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: A new animal model for arenaviral ... Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: A new animal model for arenaviral ... Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus : A new animal model for arenaviral ... title = "Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: A new animal model for ...
RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.. Meningitis, ... HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; BUNYAVIRIDAE INFECTIONS; PICORNAVIRIDAE INFECTIONS ... TOGAVIRIDAE INFECTIONS; FLAVIVIRIDAE INFECTIONS; RUBELLA; BUNYAVIRIDAE INFECTIONS; ORBIVIRUS infections; PICORNAVIRIDAE ...
... acute HIV infection is critical to understanding subtype-specific pathophysiologic differences, since u... ... RHABDOVIRIDAE INFECTIONS; ARENAVIRIDAE INFECTIONS; HERPESVIRIDAE INFECTIONS; ADENOVIRIDAE INFECTIONS; JC VIRUS infections; and ... DNA VIRUS INFECTIONS; RNA VIRUS INFECTIONS; BACTERIAL INFECTIONS; MYCOPLASMA INFECTIONS; SPIROCHAETALES INFECTIONS; fungal ... PARAMYXOVIRIDAE INFECTIONS; ORTHOMYXOVIRIDAE INFECTIONS; RETROVIRIDAE INFECTIONS; and ARENAVIRIDAE INFECTIONS.. Meningitis, ...
T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of ... Arenaviridae Infections / immunology* * CD8-Positive T-Lymphocytes / immunology* * Cell Movement / immunology * Cells, Cultured ... CD8(+) T cells eliminate intracellular infections through two contact-dependent effector functions: cytolysis and secretion of ...
Arenaviridae Infections / immunology * Arenaviridae Infections / virology * Cell Differentiation / immunology* * Flow Cytometry ... In a viral infection model, miR-17∼92 restrained the expression of genes inappropriate to the TFH cell subset, including the ...
Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae). Am J Trop Med Hyg. 2001;65: ... Salvato MS, Clegg JCS, Buchmeier MJ, Charrel RN, Gonzalez J-P, Lukashevich IS, Family Arenaviridae. In: Fauquet CM, Mayo MA, ... Other means of infection may include ingestion of infected rodents (13).. Human consumption of woodrats is common in rural ... The anti-arenavirus antibody in the pocket mice and kangaroo rat in this study may be a consequence of infection with an ...
Categories: Arenaviridae Infections Image Types: Photo, Illustrations, Video, Color, Black&White, PublicDomain, ...
Arenaviridae Infections Bioterrorism Dengue Hemorrhagic Fever Flavivirus Infections Hantavirus Infections Hemorrhagic Fever, ... Arenaviridae Arenaviruses, New World Bunyaviridae Dengue Virus Ebola virus Encephalitis Viruses, Tick-Borne Filoviridae ...
... and Filovirus Infections - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical ... The Arenaviridae includes lymphocytic choriomeningitis virus, Lassa fever virus, Mopeia virus, Tacaribe virus, Junin virus, ... Some infections (eg, West Nile virus infection, Colorado tick fever, dengue, Zika virus) have been spread by blood transfusion ... Overview of Herpesvirus Infections. There are eight different types of herpesviruses that infect humans. Each type manifests in ...
... following YFV infection. Histologically, livers of animals in the flavivirus-immune and control groups showed comparable levels ... many of which appeared clinically ill or died after YFV infection, the flavivirus-immune animals remained asymptomatic. The ... whereas naive hamsters developed extensive microvesicular steatosis in the liver following YFV infection. These findings ... suggest that hepatocytic steatosis is an adverse microscopic feature associated with severe disease in YFV infection. Our ...
... viruses that cause chronic infections in rodents and zoonotically acquired disease in humans through rodent excreta, especially ... No specific medical care is required for mild infections associated with any of the Arenaviridae. Specific and/or careful ... Arenaviridae: the viruses and their replication. Knipe DL, and Howley, PM. Fields Virology. 4. Philadelphia, PA: Lippencott- ... Arenavirus infection--Connecticut, 1994. MMWR Morb Mortal Wkly Rep. 1994 Sep 2. 43(34):635-6. [Medline]. ...
Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae).. Genetic evidence for a ...
... it was suggested that LUJV infection in guinea pigs appears to cause a more severe disease than JUNV or Lassa infection; ... The Arenaviridae family, whose prototype is lymphocytic chorio-meningitis virus (LCMV), contains more than 20 members with ... A productive infection of EC in culture with JUNV induces the expression of ICAM-1 and, to a lesser extent, VCAM-1 [28]. This ... In addition, the infection of EC with a virulent strain of JUNV, but not a non-virulent isolate, markedly induced the ...
A method of inhibiting viral infection in a mammal in need of same, includes administering an effective amount of at least one ... Arenaviridae. Lymphocytic choriomeningitis. Enveloped. Complex. ss. virus. 6.. Retroviridae. HIV-1, HIV-2, HTLV-I. Enveloped. ... for administration to a human or animal experiencing a viral infection or at risk of a viral infection. Such pharmaceutical ... The infection pathway and timing of RSV is well known, and is set forth in the lower right corner. As can be seen, at any time ...
METHODS FOR TREATING ARENAVIRIDAE AND CORONAVIRIDAE VIRUS INFECTIONS. Provided are methods for treating Arenaviridae and ... Coronaviridae virus infections by administering nucleosides and prodrugs thereof, of Formula I: ... ...
encoded search term (Ebola Virus Infection) and Ebola Virus Infection What to Read Next on Medscape ... Ebola Virus Infection. Updated: Jan 14, 2021 * Author: John W King, MD; Chief Editor: Pranatharthi Haran Chandrasekar, MBBS, MD ... Among infection survivors, only males had been shown to transmit the virus, via semen, in which the virus can persist for up to ... In fatal infections, the hosts tissues and blood contain large numbers of Ebola virions, and the tissues and body fluids are ...
Hantavirus Infection - Etiology, pathophysiology, symptoms, signs, diagnosis & prognosis from the Merck Manuals - Medical ... Arboviruses, Arenaviridae, and Filoviridae Overview of Arbovirus, Arenavirus, and Filovirus Infections. Dengue ... Infection is transmitted to humans via inhalation of excreta of sigmodontine rodents (especially the deer mouse for Sin Nombre ... Serologic diagnosis in North America must be able to differentiate between Seoul and Sin Nombre virus infections due to ...
Arbovirus infections synonyms, Arbovirus infections pronunciation, Arbovirus infections translation, English dictionary ... definition of Arbovirus infections. n. Any of a large group of RNA viruses that are transmitted by arthropods, such as ... Arenaviridae - a family of arborviruses carried by arthropods. Rhabdoviridae - a family of arborviruses carried by arthropods ... Mosquito-borne viral infections in Southern Africa: a public health perspective: Of the six mosquito-borne viral infections of ...
Prophylactic ribavirin may be effective for some Bunyaviridae and Arenaviridae infections (available only as IND). Isolation ... Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa ... and hemorrhagic fever with renal syndrome due to Old World Hantavirus infection) and should be used only under an ...
Lassa Fever is caused by an infection with LASV, a member of the Arenaviridae virus family. The virus can cause severe ... The infection of 39 healthcare workers highlights the need for infection prevention and control measurements to stop the spread ... Upon infection of human cells, the MVA-driven expression of the two proteins leads to the formation of non-infectious VLPs that ... The production of VLPs in the person being vaccinated mimics virus production in a natural infection, stimulating both the ...
A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus- ... including Arenaviridae (e.g., Lassa fever virus (LFV)), Filoviridae (e.g., Ebola virus (EBOV) and Marburg virus (MBGV)); ... accounting for the disproportionate association of chronic HDV infection with terminal liver disease. Although HDV infection ... Upon infection by HBV, the incomplete partial double stranded DNA is repaired to form a 3.2-kb cccDNA, which serves as a ...
The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. ... Most infections spread among adult rodents through scratches and bites, although for certain arenaviruses, the virus passes ... Viruses in the family Arenaviridae are generally spread by rodents, with each virus associated with one, or a few, closely ... There are some arenaviruses - both New and Old World - that have been identified in host animals, but no human infection has ...
About 80% of people infected by Lassa virus have no symptoms but the virus establishes a life-long persistent infection. The ... The systematic collection will allow to corroborate the possible association between arenaviruses infection and pathogenesis of ... It is also reported person-to-person infections. ... The Arenaviridae family (Arenavirus) consists of two single ... i Scheme of arenavirus infection ways that may cause latent and persistent infection in the humans oral cavity, causing ...
2. Hantavirus infection. V. Arenaviridae. VI. Filoviridae. 1. Ebola Hemorrhagic Fever. 2. Marburg Hemorrhagic Fever. Lecture VI ... 2. Human Papillomavirus (HPV) Infections. 2.1 Venereal Warts Infection. 2.2 Mouth Cancer. III. Family Adenoviridae. Lecture IV ... 1. Herpes Simplex Virus 1 (HSV-1) Infection. 2. Herpes Simplex Virus 2 (HSV-2) Infection. Genus Varicellovirus. 3. Chickenpox ... 2. Coxsackievirus Infections. 3. Hepatitis A II. Family Flaviridae. 1. Hepatitis C. 2. Hepatitis G. 3. Yellow Fever. 4. Dengue ...
Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa ... After the first infection, macrophages display antibodies on their cell membranes specific to the dengue virus. By attaching to ... The family Arenaviridae include the viruses responsible for Lassa fever (Lassa virus), Lujo virus, Argentine (Junin virus), ... The order Bunyavirales includes the families Arenaviridae, Filoviridae, and all members of the former family Bunyaviridae, ...
"Methods for treating arenaviridae and coronaviridae virus infections", published 16 March 2017, issued 9 April 2019, assigned ... and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection ... but was then repurposed and studied as a potential treatment for Ebola virus disease and Marburg virus infections. According to ... "Methods for treating Filoviridae virus infections", published 5 May 2016, issued 8 August 2017, assigned to Gilead Sciences Inc ...
  • a genus of viruses of the family Arenaviridae that includes lymphocytic choriomeningitic (LCM) virus, Lassa virus, and viruses of the Tacaribe complex. (thefreedictionary.com)
  • Any of a family of single-stranded RNA viruses that cause chronic infections in rodents and when transmitted to humans cause various hemorrhagic diseases, including Lassa fever. (thefreedictionary.com)
  • The single genus of the family Arenaviridae, which includes Lassa virus, lymphocytic choriomeningitis virus and the Tacaribe group of haemorrhagic fever (e.g. (thefreedictionary.com)
  • Virology The single genus of the family Arenaviridae, which includes Lassa virus, lymphocytic choriomeningitis virus and hemorrhagic fever-eg Junin, Machupo-viruses Vector Rodents. (thefreedictionary.com)
  • Any of the family of Arenaviridae of viruses which includes those causing LASSA FEVER and LYMPHOCYTIC CHORIOMENINGITIS . (thefreedictionary.com)
  • Antiviral therapy with intravenous ribavirin may be useful in Bunyaviridae and Arenaviridae infections (specifically Lassa fever, Rift Valley fever, Crimean-Congo hemorrhagic fever, and hemorrhagic fever with renal syndrome due to Old World Hantavirus infection) and should be used only under an investigational new drug (IND) protocol. (nih.gov)
  • About 80% of people infected by Lassa virus have no symptoms but the virus establishes a life-long persistent infection. (springer.com)
  • The family Arenaviridae include the viruses responsible for Lassa fever (Lassa virus), Lujo virus, Argentine (Junin virus), Bolivian (Machupo virus), Brazilian (Sabiá virus), Chapare hemorrhagic fever (Chapare virus), Venezuelan (Guanarito virus) and Whitewater Arroyo virus hemorrhagic fevers. (wikipedia.org)
  • Most Lassa virus infections are a consequence of multiple, independent transmissions from the rodent reservoir. (virology.ws)
  • Furthermore, Lassa virus diversity in the rodent host is greater than in humans, likely a consequence of the longer, persistent infections that take place in the mouse. (virology.ws)
  • Compound administration significantly decreased the viral RNA load in cultured cells that were infected with viruses of the family Flaviviridae , including West Nile virus, dengue virus, and hepatitis C virus, as well as viruses of the families Filoviridae (Ebola virus), Orthomyxoviridae (influenza A virus), Arenaviridae (Lassa virus), and Paramyxoviridae (respiratory syncytial virus, Nipah virus) to suppress infectious virus production. (asm.org)
  • These molecules can prophylactically or therapeutically control infection in cell culture by pathogenic RNA viruses, including West Nile virus, dengue virus, hepatitis C virus, influenza A virus, respiratory syncytial virus, Nipah virus, Lassa virus, and Ebola virus. (asm.org)
  • Upon vaccination, these immunogens form Virus-Like Particles (VLPs) in the host which will, in turn, induce immunity against subsequent infections with the Lassa virus. (precisionvaccinations.com)
  • Lassa fever is caused by an infection with Lassa virus, a member of the Arenaviridae virus family. (precisionvaccinations.com)
  • For example, Lassa virus, Crimean-Congo hemorrhagic fever virus, and Rift Valley fever virus are now endemic to many parts of the world and have annual outbreaks with infections collectively numbering into the thousands. (nih.gov)
  • About 80% of human Lassa fever infections are mild or asymptomatic. (who.int)
  • Estimates of annual incidences of Lassa fever across this region reach as high as 300,000 infections and 5,000 deaths. (vhfc.org)
  • Lassa virus is a member of the Arenaviridae virus family. (vhfc.org)
  • No vaccine for Lassa fever is currently available for use in humans, and the only available drug, ribavirin , is only effective if administered early in infection (within the first 6 days after disease onset). (vhfc.org)
  • One of the hallmarks of Lassa virus infection is the apparent absence of functional antibodies during acute infection. (vhfc.org)
  • Lassa Fever Lassa fever virus, a member of the Arenaviridae family, causes severe and often fatal hemorrhagic illnesses in an overlapping region with Ebola. (wikipedia.org)
  • In contrast to the unpredictable epidemics of filoviruses, the Lassa virus is endemic in West Africa with an annual incidence of >300,000 infections, resulting in 5,000-10,000 deaths. (wikipedia.org)
  • Data from a recent independent study suggest that the number of annual Lassa Fever cases may be much higher, reaching three million infections and 67,000 deaths, putting as many as 200 million persons at risk. (wikipedia.org)
  • The Tacaribe serocomplex (family Arenaviridae, genus Arenavirus ) comprises 7 North American viruses ( Table 1 ) and 15 South American viruses ( 9 ). (cdc.gov)
  • Most viruses associated with hemorrhagic fevers are classified in the families Arenaviridae and Filoviridae . (merckmanuals.com)
  • Arenaviridae: the viruses and their replication. (medscape.com)
  • Viruses in the family Arenaviridae are generally spread by rodents, with each virus associated with one, or a few, closely related rodent species that serve as the virus' natural reservoir. (cdc.gov)
  • VHFs may be caused by five distinct families of RNA viruses: the families Filoviridae, Flaviviridae, Rhabdoviridae, and several member families of the Bunyavirales order such as Arenaviridae, and Hantaviridae. (wikipedia.org)
  • The Tacaribe serocomplex viruses (family Arenaviridae , genus Arenavirus ) known to occur in Venezuela are Guanarito virus (GTOV) and Pirital virus (PIRV) ( 1 , 2 ). (cdc.gov)
  • View Department of Pathology profile » My main research interest is to better understand the mechanisms that enable emerging viruses to evade host immune responses and cause disease, and to identify cellular factors that contribute to viral infection. (utmb.edu)
  • This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future. (uzh.ch)
  • Infection due to Hantavirus and other rodent-borne viruses]. (cdc.gov)
  • The Arenaviridae are a diverse and globally distributed collection of viruses that are maintained primarily by rodent reservoirs. (cdc.gov)
  • The Arenaviridae is a diverse and growing family of viruses that already includes more than 25 distinct species. (umn.edu)
  • however, apoptosis is known to play an important role in controlling infection of many viruses. (umn.edu)
  • The newly discovered viruses appear in every family or genus of RNA virus associated with vertebrate infection, including those containing human pathogens such as influenza virus, the Arenaviridae and Filoviridae families, and have branching orders that broadly reflected the phylogenetic history of their hosts. (dhushara.com)
  • A study of two viruses that bind to the same cell surface receptor protein reveals how a cellular protein can change to prevent infection without affecting its role in the cell. (virology.ws)
  • We tested a lead compound and derivatives for the ability to suppress infections caused by a broad range of RNA viruses. (asm.org)
  • This work identifies a novel class of host-directed immune modulatory molecules that activate IRF3 to promote host antiviral responses to broadly suppress infections caused by RNA viruses of distinct genera. (asm.org)
  • IMPORTANCE Incidences of emerging and reemerging RNA viruses highlight a desperate need for broad-spectrum antiviral agents that can effectively control infections caused by viruses of distinct genera. (asm.org)
  • Differential sensitivity of differentiated epithelial cells to respiratory viruses reveals different viral strategies of host infection. (naver.com)
  • Infections can lead to severe disease, death, or long-term sequalae in survivors, and treatment costs can be a substantial burden on national healthcare systems, particularly in developing nations where these viruses are now regularly circulating. (nih.gov)
  • Patients infected with high-hazard viruses: scientific basis for infection control. (canarydatabase.org)
  • Study the structure, mode of transmission and diseases associated with the Arenaviridae family of viruses. (study.com)
  • Recognition that viral infection follows nerve pathways enabled the development of viruses for neuronal circuit tracing [6] - [8] . (prolekare.cz)
  • Viral hemorrhagic fever (VHF) is an acute systemic febrile syndrome caused by a diverse group of RNA viruses from the Arenaviridae , Bunyaviridae , Filoviridae , and Flaviviridae viral families [1] - [3] . (prolekarniky.cz)
  • Prophylactic ribavirin may be effective for some Bunyaviridae and Arenaviridae infections (available only as IND). (nih.gov)
  • The order Bunyavirales includes the families Arenaviridae, Filoviridae, and all members of the former family Bunyaviridae, especially Peribunyaviridae. (wikipedia.org)
  • A family Flaviviridae along with families Togaviridae, Bunyaviridae, Reoviridae and Arenaviridae had been previously classified as Arboviridae (arthropod-borne). (edu.pl)
  • In rare cases in health care and family settings, some arenaviruses are associated with secondary person-to-person infection. (thefreedictionary.com)
  • In the rodent, arenaviruses usually establish a persistent chronic infection with few symptoms [ 1 ]. (mdpi.com)
  • Most infections spread among adult rodents through scratches and bites, although for certain arenaviruses, the virus passes from mother to offspring during pregnancy. (cdc.gov)
  • There are some arenaviruses - both New and Old World - that have been identified in host animals, but no human infection has been reported yet. (cdc.gov)
  • The systematic collection will allow to corroborate the possible association between arenaviruses infection and pathogenesis of odontogenic tumors in humans. (springer.com)
  • The new AG129 mouse TCRV infection model provides a safe and cost-effective means to conduct early-stage pre-clinical evaluations of candidate antiviral therapies that target clade B arenaviruses. (pubmedcentralcanada.ca)
  • Here we show that infection with Tacaribe virus (TCRV), which is widely considered the prototype for non-pathogenic arenaviruses, leads to stronger induction of apoptosis than does infection with its human-pathogenic relative Junı´n virus. (umn.edu)
  • The Arenaviridae family , whose prototype is lymphocytic chorio-meningitis virus (LCMV), contains more than 20 members with diverse geographical distributions [ 1 ]. (mdpi.com)
  • 10%), rarely replicate in the white pulp, and generate a robust anti-LCMV CTL response that clears the virus infection. (springer.com)
  • These data indicate that LCMV infection influences DC maturation and migration, leading to decreased T cell stimulatory capacity of DCs, events essential for the initiation of immune responses. (springer.com)
  • In the present study, we examine the role of MyD88 in the CD4(+) T-cell response following lymphocytic choriomeningitis virus (LCMV) infection. (umassmed.edu)
  • We demonstrate that wild-type (WT) mice developed a CD4(+) T-cell-mediated wasting disease after intracranial infection with LCMV. (umassmed.edu)
  • Importantly, when MyD88 KO CD4(+) T cells were reconstituted with an MyD88-expressing lentivirus, the rescued CD4(+) T cells were able to respond to LCMV infection and support IgG2a antibody production. (umassmed.edu)
  • Blockade of chronic type I interferon signaling to control persistent LCMV infection. (nih.gov)
  • A ) Splenic virus titers ± SD after acute LCMV-Arm (black) and persistent LCMV-Cl13 (red) infection (left). (nih.gov)
  • C ) Mx1, OAS , and IRF3 mRNA expression relative to HPRT in the indicated IL-10+ (GFP+, green) or IL-10− (GFP−, black) splenic DCs (top) or macrophages (bottom) 9 days after LCMV-Cl13 infection of Vert-X IL-10 reporter mice. (nih.gov)
  • A ) Representative histograms and summarized quantification of geometric mean fluorescence intensity (GMFI) show PD-L1 on splenic DCs and macrophages 9 days after LCMV-Cl13 infection in wild-type (WT, black) and Ifnar1 −/− (red) mice. (nih.gov)
  • Scatter plots show plasma IL-10 levels on day 9 after LCMV-Cl13 infection. (nih.gov)
  • Bar graphs measure IL-10 production by cultured splenocytes (in the absence of exogenous stimulation) isolated 9 days after LCMV-Cl13 infection from WT or Ifnar1 −/− mice. (nih.gov)
  • Plasma viral titers in WT or Ifnar1 −/− mice on day 9 after LCMV-Cl13 infection are shown to the far right. (nih.gov)
  • We found that an RIP-LCMV transgenic mouse line exhibiting higher levels of beta cell GP expression developed more severe diabetes after LCMV infection or transfer of high numbers of activated autoreactive T cells. (nih.gov)
  • The graphs show percent diabetic mice after LCMV infection (A) or after P14 transfer (B). (nih.gov)
  • PML −/− mice exhibited accelerated primary footpad swelling reactions to very-low-dose LCMV, higher swelling peaks upon high-dose inoculation, and higher viral loads in the early phase of systemic LCMV infection. (asm.org)
  • T-cell-mediated hepatitis and consequent mortality upon infection with a hepatotropic LCMV strain required 10- to 100-times-lower inocula despite normal cytotoxic T-lymphocyte reactivity in PML −/− mice. (asm.org)
  • Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae that was initially isolated in 1933. (news-medical.net)
  • Although LCMV is most commonly recognized as causing neurological disease, as its name implies, infection without symptoms or mild febrile illnesses are common clinical manifestations. (news-medical.net)
  • Here, we investigated whether specific antibody responses contribute to control of lymphocytic choriomeningitis virus (LCMV), a prototypic mouse model of systemic persistent infection. (ox.ac.uk)
  • It highlights the importance of infection prevention practices that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to even a small amount of LCMV can lead to a severe, life-threatening infection. (biomedcentral.com)
  • LCMV infection is usually asymptomatic or mild and self-limiting, but rarely can manifest itself as severe disease such as meningitis and encephalitis [ 1 ]. (biomedcentral.com)
  • House mice ( Mus musculus ) are the common host of LCMV, a member of the family of Arenaviridae . (biomedcentral.com)
  • A previous case report of lab-acquired LCMV infection was based on indirect evidence by serological tests, not direct detection of viral RNA by PCR [ 6 ]. (biomedcentral.com)
  • This highlights the importance of infect prevention strategies that comprise particularly well established safety precaution protocols in research laboratories handling this pathogenic virus, because exposure to LCMV can lead to a life-threatening infection. (biomedcentral.com)
  • Understanding Experimental LCMV Infection of Mice: The Role of Mathematical Models. (nih.gov)
  • In this review, we analyse the mathematical modelling approaches to LCMV infection in mice that resulted in quantification of some fundamental parameters of the CTL-mediated virus control including the rates of T cell turnover, infected target cell elimination, and precursor frequencies. (nih.gov)
  • a) Schematic view of acute and chronic LCMV infections including virus and cytotoxic T lymphocyte (CTL) dynamics. (nih.gov)
  • One of the best-studied model systems of viral infections is that of the lymphocytic choriomeningitis virus (LCMV) in mice (Figure 1) [1-3]. (nih.gov)
  • LCMV is an RNA virus of Arenaviridae that is noncytopathic in vivo. (nih.gov)
  • Another important feature of the LCMV model system is the existence of several well-characterized viral strains that differ in their replicative capacity, host range (cell tropism and mouse strain), and experimental routes of infection (intracranial versus intraperitoneal (i.p.) or intravenous (i.v.)) and thus show different infection outcomes. (nih.gov)
  • The patient was admitted to the hospital and placed in phocytic choriomeningitis virus (LCMV) infection in respiratory isolation with a diagnosis of acute meningitis, Michigan to be investigated by public health authorities and likely of viral origin, and mild pancreatitis. (cdc.gov)
  • She was given provide evidence of the focal nature of LCMV infection in supportive care with intravenous fluids, acyclovir, and domestic rodents. (cdc.gov)
  • The patient improved and was released after 7 days of gitis due to LCMV infection in a Michigan resident. (cdc.gov)
  • Viral coinfection during the Th2-dominated granulomatous phase of the schistosome infection resulted in induction of a strong LCMV-specific T cell response, with infiltration of high numbers of LCMV-specific IFN-gamma-producing CD8+ cells into the liver. (ox.ac.uk)
  • Our experimental results support earlier anecdotal reports that prior exposure of humans to heterologous flaviviruses reduces subsequent risk of fatal YFV infection. (ajtmh.org)
  • Infection is transmitted to humans via inhalation of rodent excreta. (merckmanuals.com)
  • As humans urbanize and farm larger swaths of previously wild lands, the risk of rodent-transmitted infections increases. (elifesciences.org)
  • Multidrug-resistant TB Isoniazid, rifampin, streptomycin, and (MDR TB) is an infection resistant to at ethambutol least two first-line antiTB drugs, isoniazid and rifampicin Relatively uncommon disease for humans, but when left untreated, has 95% fatality rate Chloramphenicol, doxycycline, sulfisoxazole, or cotrimoxazole. (scribd.com)
  • polymerase congenital infections in humans ( 1 , 2 ). (cdc.gov)
  • Probably an inapparent infection in naturally infected house mice, but has been isolated from humans, monkeys, dogs, field mice of Apodemus sp, hamsters and guinea pigs. (rrnursingschool.biz)
  • In humans infection may be inapparent or an influenza-like fever but lymphocytic choriomeningitis of varying severity may occur. (rrnursingschool.biz)
  • The frequent interactions of rodents with humans make them a common source of zoonotic infections. (prolekare.cz)
  • Fully revised and updated by the new author team, partI presents the fundamental principles of virology related to animal infection and disease, and partII addresses the clinical features, pathogenesis, diagnosis, epidemiology and prevention of individual diseases. (barnesandnoble.com)
  • This important role for virus-specific antibodies may be similarly underappreciated in other primarily T cell-controlled infections such as HIV and hepatitis C virus, and we suggest this contribution of antibodies be given consideration in future strategies for vaccination and immunotherapy. (ox.ac.uk)
  • In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. (uzh.ch)
  • The discovery of Bear Canyon virus is the first unequivocal evidence that the virus family Arenaviridae is naturally associated with the rodent genus Peromyscus and that a Tacaribe serocomplex virus occurs in California. (cdc.gov)
  • Rubella virus "German Measles" infection during pregnancy is one of the most serious causing congenital rubella syndrome with serious malformations of the developing fetus. (edu.au)
  • Banerjee C, Allen LJ, Salazar-Bravo J. Models for an arenavirus infection in a rodent population: consequences of horizontal, vertical and sexual transmission. (medscape.com)
  • Arenavirus infection--Connecticut, 1994. (medscape.com)
  • Presently, there are no clade B arenavirus infection models outside of newborn mice suitable for early stage antiviral drug development and proof-of-concept studies. (pubmedcentralcanada.ca)
  • CONCLUSIONS: These results show the population studied may present exposure to arenavirus infection. (bvsalud.org)
  • Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral hemorrhagic fever. (ajtmh.org)
  • Tesh, R. B. / Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus : A new animal model for arenaviral hemorrhagic fever . (utmb.edu)
  • exceptions include dengue , yellow fever , Zika virus infection , and chikungunya disease , which can be transmitted from person to person via mosquitoes. (merckmanuals.com)
  • Some infections (eg, West Nile virus infection , Colorado tick fever, dengue , Zika virus ) have been spread by blood transfusion or organ donation. (merckmanuals.com)
  • Using a recently described hamster model of severe yellow fever (YF), we examined the hypothesis that prior infection with heterologous flaviviruses protects against severe or fatal YF. (ajtmh.org)
  • Yellow fever in the Gambia, 1978-1979: epidemiologic aspects with observations on the occurrence of Orungo virus infections. (ajtmh.org)
  • Specific and/or careful symptomatic care is needed in more severe infections associated with those agents linked to hemorrhagic fever. (medscape.com)
  • Infection with FRV was not associated with clinical disease in animals but could potentially be disguised by other arbovirus infections , such as bovine ephemeral fever (49). (thefreedictionary.com)
  • As in other arbovirus infections , sandfly fever may also be associated with aseptic meningitis. (thefreedictionary.com)
  • Viral hemorrhagic fevers (VHFs) are a diverse group of animal and human illnesses in which fever and hemorrhage are caused by a viral infection. (wikipedia.org)
  • There are several guinea pig and nonhuman primate models based on infection with authentic BSL-4 arenaviral hemorrhagic fever agents, but they are not readily available to most researchers [3] . (pubmedcentralcanada.ca)
  • Furthermore this may occur either directly by the infection or indirectly by the associated maternal fever and other side-effects of the infection. (edu.au)
  • Infections caused by other donor-derived pathogens in transplant recipients are often asymptomatic or may result in nonspecific signs and symptoms, including unexplained fever or end-organ injury (4). (thefreelibrary.com)
  • Argentine haemorrhagic fever (AHF) is a systemic febrile syndrome characterized by several haematological and neurological alterations caused by Junín virus (JUNV), a member of the Arenaviridae family. (jove.com)
  • Argentine hemorrhagic fever (AHF) is an endemo-epidemic disease caused by Junín virus (JUNV), a member of the arenaviridae family. (prolekarniky.cz)
  • Most infections are asymptomatic. (bioportfolio.com)
  • Many of these infections are asymptomatic. (merckmanuals.com)
  • In contrast to control (naive) hamsters, many of which appeared clinically ill or died after YFV infection, the flavivirus-immune animals remained asymptomatic. (ajtmh.org)
  • In mild forms, infection is often asymptomatic. (merckmanuals.com)
  • Virus diseases caused by the ARENAVIRIDAE. (umassmed.edu)
  • The Danish Study Group of Infections of the Brain is a collaboration between all departments of infectious diseases in Denmark. (bioportfolio.com)
  • Members of the Institute for Human Infections & Immunity are University of Texas Medical Branch faculty actively engaged in the study of infectious diseases and immunity. (utmb.edu)
  • View DIVA Project profile » By using my experience in network visualization and analysis, I collaborate with researchers at the Institute for Human Infections and Immunity and the Galveston National Laboratory to analyze complex data related to infectious diseases, in addition to developing new methods that accelerate the translation of discoveries into effective treatments. (utmb.edu)
  • A UCLA research team has identified a new paradigm for understanding the regulation of the immune system, potentially paving the way for new approaches to treating infections and immune-related diseases such as type 1 diabetes and certain cancers. (news-medical.net)
  • HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. (meta.org)
  • Laboratory diagnosis of hantavirus infection is established by serologic tests and reverse transcriptase-polymerase chain reaction (RT-PCR). (merckmanuals.com)
  • Results of this pilot study suggest that the Pirital virus-hamster model is a very promising new small animal model for studying the pathogenesis of arenavirus infections, particularly, the mechanism of direct virus-induced hepatic injury. (ajtmh.org)
  • In contrast, MyD88 knockout (KO) mice did not develop wasting disease in response to the same infection. (umassmed.edu)
  • We demonstrated in mice that blockade of IFN-I signaling diminished chronic immune activation and immune suppression, restored lymphoid tissue architecture, and increased immune parameters associated with control of virus replication, ultimately facilitating clearance of the persistent infection. (nih.gov)
  • Here, we characterized the infection of C57BL/6J wild-type and Daf1-/- mice, which have an enhanced host response, with a virulent Leptospira interrogans strain at 14 days post-infection, its persistence in the kidney, and its link to kidney fibrosis at 90 days post-infection. (jove.com)
  • At the chronic stage, Daf1-/- mice showed greater inflammation and fibrosis than at 14 days post-infection and higher levels at all times than the wild-type counterpart. (jove.com)
  • Newborn mice are highly susceptible to JUNV and the course of infection has been associated with the viral strain used. (jove.com)
  • Mice lacking the type I interferon receptor (IFNAR −/− ) were used as an in vivo lethal model for SFTSV infection. (asm.org)
  • When a colony of laboratory mice becomes infected, disease appears in young mice infected in utero but the infection soon becomes latent. (rrnursingschool.biz)
  • This study will compare the efficacy, safety and tolerability of intravenous ertapenem versus another intravenous antibiotic in the treatment of moderate to severe diabetic foot infection. (bioportfolio.com)
  • These findings suggest that hepatocytic steatosis is an adverse microscopic feature associated with severe disease in YFV infection. (ajtmh.org)
  • In some areas of the world, arenavirus infections in people are relatively common and can cause severe disease. (cdc.gov)
  • Viral infections can range in their effects from no discernable impact through to severe impacts on development. (edu.au)
  • Because of immunosuppression and underlying co-existing conditions in transplant recipients, these infections can be severe and fatal. (thefreelibrary.com)
  • 1 in 5 infections result in severe disease, where the virus affects several organs such as the liver, spleen and kidneys. (who.int)
  • These findings reveal a novel role for antigen in maintaining virus-specific CD8 T cells during persistent infection and provide insight toward understanding T cell differentiation in chronic infection. (labome.org)
  • Here, we assess permissivity and kinetics of RSV replication in primary human placental cells, examine their potential to transfer this infection to neighboring cells, and measure the inflammatory response evoked by the virus. (edu.au)
  • Because the virus-receptor interaction is essential for viral replication, host cells with a mutation in the receptor gene that prevents virus infection survive and eventually dominate the population. (virology.ws)
  • The amount of hepatocyte turnover that occurred during resolution of transient hepadnavirus infections was lower when virus replication was inhibited with entecavir. (naver.com)
  • Virus infections represent complex biological systems governed by multiple-level regulatory processes of virus replication and host immune responses. (nih.gov)
  • The initial interaction of host and virus particles in peripheral tissue prior to nervous system infection can be complex, often involving significant productive replication and spread among a variety of cell types, including those present at mucosal surfaces as well as those of the immune and nervous systems. (prolekare.cz)
  • Tick-borne infections and co-infections in patients with non-specific symptoms in Poland: Tick-borne infections and co-infections. (bioportfolio.com)
  • The aim of the study was the evaluation of the frequency of infections and co-infections among patients hospitalized because of non-specific symptoms after a tick bite. (bioportfolio.com)
  • Since 2015, Zika outbreaks have been recorded in approximately 60 countries and territories, with symptoms similar to other arbovirus infections such as Dengue. (thefreedictionary.com)
  • These recommendations evolved from observations during the SARS epidemic that failure to implement basic source control measures with patients, visitors, and healthcare personnel with signs and symptoms of respiratory tract infection may have contributed to SARS coronavirus (SARS-CoV) transmission. (cdc.gov)
  • The signs and symptoms of donor-derived infections can be obscured by co-existing conditions in the transplant recipient, or they can appear more abruptly than in natural infection because of a higher inoculum of organisms and immunosuppression in the transplant recipient. (thefreelibrary.com)
  • Cytomegalovirus is a common infection among adults with little to no symptoms. (meta.org)
  • Thus, PML is a contributor to innate immunity, defining host susceptibility to viral infections and to immunopathology. (asm.org)
  • Thus, small molecule agonists that can promote IRF3 activation and induce innate immune gene expression could serve as antivirals to induce tissue-wide innate immunity for effective control of virus infection. (asm.org)
  • Their recent study, which was published in the renowned scientific journal Immunity, investigated the communication between inflammation and liver metabolism during chronic viral infection. (news-medical.net)
  • Exhausted T cells express multiple co-inhibitory molecules that impair their function and limit immunity to chronic viral infection. (ox.ac.uk)
  • Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses. (google.it)
  • We identified small molecule compounds that can selectively activate IRF3 for the purpose of identifying drug-like molecules that can be developed for the treatment of viral infections. (asm.org)
  • A method for diagnosing hepatitis virus infection or a hepatitis disease condition in a subject based on hepatitis virus-associated biomarkers present on exosomes in a bodily fluid sample from the subject is disclosed. (freepatentsonline.com)
  • Remdesivir was originally developed to treat hepatitis C, and was subsequently investigated for Ebola virus disease and Marburg virus infections before being studied as a post-infection treatment for COVID-19. (wikipedia.org)
  • Kaushik N, Anang S, Ganti KP, Surjit M. Zinc: A Potential Antiviral Against Hepatitis E Virus Infection? (harvard.edu)
  • Autoimmune hemolytic anemia in a young man with acute hepatitis E infection. (harvard.edu)
  • 16. The method of claim 13, wherein the persistent infection is an infection with hepatitis c virus. (patentsencyclopedia.com)
  • The incidences of common arbovirus infections in Latin America are very high: approximately 173 cases/100000 inhabitants for dengue, 8 cases/100000 inhabitants for chikungunya, and 45 cases/100000 inhabitants for Zika. (thefreedictionary.com)
  • little is known about the specific signaling pathways activated on microglia after arbovirus infections concurrent with prion disease. (thefreedictionary.com)
  • A network of research laboratories capable of prompt diagnosing of arbovirus infections should be developed worldwide wherever Aedes albopictus exists in order to control chikungunya. (thefreedictionary.com)
  • In this review we covered encephalitides and other sequelae of arbovirus infections. (edu.pl)
  • Systematic reviews of point-of-care tests for the diagnosis of urogenital Chlamydia trachomatis infections. (bioportfolio.com)
  • Serologic diagnosis in North America must be able to differentiate between Seoul and Sin Nombre virus infections due to potential cross-reactivity. (merckmanuals.com)
  • The Diagnosis of Virus Infections 6. (barnesandnoble.com)
  • WHO estimates that 131 million new cases of urogenital Chlamydia trachomatis (CT) infections occur globally every year. (bioportfolio.com)
  • Death can occur during the diuretic phase, secondary to volume depletion, electrolyte disturbances, or secondary infections. (merckmanuals.com)
  • Person-to-person infections and laboratory transmission can also occur, particularly in hospitals lacking adequate infection prevention and control measures. (who.int)
  • Mammarenavirus infections contribute significantly to the human disease burden in both Africa and the Americas, but little data exists for Asia. (elifesciences.org)
  • Here we report the presence of a novel mammarenavirus and of a genetic variant of the Wēnzhōu virus and provide evidence of mammarenavirus-associated human infection in Asia. (elifesciences.org)
  • Outbreak of lymphocytic choriomeningitis virus infections in medical center personnel. (medscape.com)
  • Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation. (springer.com)
  • In the mouse model of chronic Lymphocytic Choriomeningitis Virus infection, virus-specific CD8+ T cells contain a population of CD39high CD8+ T cells that is absent in functional memory cells elicited by acute infection. (ox.ac.uk)
  • Wherry E, Barber D, Kaech S, Blattman J, Ahmed R. Antigen-independent memory CD8 T cells do not develop during chronic viral infection. (labome.org)
  • Interfering with type I interferon: a novel approach to purge persistent viral infection. (nih.gov)
  • Cutting edge: persistent viral infection prevents tolerance induction and escapes immune control following CD28/CD40 blockade-based regimen. (labome.org)
  • 2. The method of claim 1, wherein the pathogen is a virus, and wherein the subject has a persistent viral infection. (patentsencyclopedia.com)
  • The term nosocomial infection is retained to refer only to infections acquired in hospitals. (cdc.gov)
  • The virus can also be transmitted from human to human through nosocomial infections. (precisionvaccinations.com)
  • Based on prospective studies performed in Guinea, Sierra Leone, Liberia, and Nigeria, it was estimated that 59 million people are at risk of LASV infections, with as many as 67,000 deaths per year [ 6 ]. (mdpi.com)
  • Respiratory syncytial virus exhibits differential tropism for distinct human placental cell types with Hofbauer cells acting as a permissive reservoir for infection [1] "Respiratory syncytial virus (RSV) is capable of transient viremia and extrapulmonary dissemination. (edu.au)
  • New York: John Wiley, p. 575 Salvato MS (editor) (1993) The Arenaviridae. (rrnursingschool.biz)
  • Buchmeier MJ and Zajuc AJ (1999) In Persistent Viral Infections, edited by R Ahmed and ISY Chen. (rrnursingschool.biz)
  • In contrast, outbreaks of Ebolavirus infection typically originate with a crossover from an animal reservoir, followed by human to human transmission. (virology.ws)
  • These findings raise concerns about using vaccines that may persist and also suggest that there may be limitations and challenges in designing effective immunological interventions for the treatment of chronic infections and tumors. (labome.org)
  • There are currently no medical treatments for chronic HPV infections, which can lead to the formation of cancerous tumors. (wikipedia.org)
  • Paramyxoviridae, subfamily Pneumovirinae) is the most common cause of lower respiratory tract infection in children. (powershow.com)
  • El inicio de signos clínicos en febrero de 2008, se asoció tanto con la infección por dengue como por leptospirosis. (bvsalud.org)
  • There were 12 co-infection cases of leptospirosis-dengue and one of leptospirosis-rickettsiosis-dengue. (bvsalud.org)
  • Male gender and relative humidity were considered risk factors for dengue, and the beginning of clinical signs in February of 2008 was associated with the infection of dengue and leptospirosis. (bvsalud.org)
  • Arenaviridae Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • A fixed-ratio combination of amoxicillin trihydrate (see AMOXICILLIN), an aminopenicillin, and potassium clavulanate (see CLAVULANIC ACID), a beta-lactamase inhibitor, used to treat a broad-spectrum of bacterial infections, especially resistant strains. (bioportfolio.com)
  • This study will establish whether the patient population of the Thai Red Cross Anonymous Clinic is suitable for the study of early, acute infection. (bioportfolio.com)
  • The virus family Arenaviridae comprises two serocomplexes (1) . (cdc.gov)
  • Malaria Globally, malaria causes 228 million infections and 405,000 deaths annually. (wikipedia.org)
  • This term reflects the inability to determine with certainty where the pathogen is acquired since patients may be colonized with or exposed to potential pathogens outside of the healthcare setting, before receiving health care, or may develop infections caused by those pathogens when exposed to the conditions associated with delivery of healthcare. (cdc.gov)
  • The risk for infections caused by pathogens transmitted through solid organ or tissue transplants (hereafter referred to as donor-derived or transplant-transmitted infections) has been recognized for decades and remains a worldwide public health problem (2). (thefreelibrary.com)