Arenaviridae: A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). Infection in rodents is persistent and silent. Vertical transmission is through milk-, saliva-, or urine-borne routes. Horizontal transmission to humans, monkeys, and other animals is important.Arenaviridae Infections: Virus diseases caused by the ARENAVIRIDAE.Arenaviruses, New World: One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. It includes JUNIN VIRUS; PICHINDE VIRUS; Amapari virus, and Machupo virus among others. They are the cause of human hemorrhagic fevers mostly in Central and South America.Arenavirus: The only genus in the family ARENAVIRIDAE. It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution.Hemorrhagic Fever, American: Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).Hemorrhagic Fevers, Viral: A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.Lassa virus: A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.Junin virus: A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. The disease is characterized by congestion, edema, generalized lymphadenopathy and hemorrhagic necrosis and is sometimes fatal.VenezuelaSigmodontinae: A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.Lassa Fever: An acute febrile human disease caused by the LASSA VIRUS.Pichinde virus: A species of ARENAVIRUS, one of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing a fatal infection in the cricetine rodent Oryzomys albigularis. Asymptomatic laboratory infection in humans has been reported.Nucleocapsid Proteins: Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Filoviridae: A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.Arboviruses: Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)Sheltered Workshops: Protective places of employment for disabled persons which provide training and employment on a temporary or permanent basis.Marburg Virus Disease: An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.Dictionaries, MedicalDictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Hemorrhagic Fever, Crimean: A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).Hemorrhagic Fever Virus, Crimean-Congo: A species of NAIROVIRUS of the family BUNYAVIRIDAE. It is primarily transmitted by ticks and causes a severe, often fatal disease in humans.Hemorrhagic Fever, Ebola: A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.Hemorrhagic Fever with Renal Syndrome: An acute febrile disease occurring predominately in Asia. It is characterized by fever, prostration, vomiting, hemorrhagic phenonema, shock, and renal failure. It is caused by any one of several closely related species of the genus Hantavirus. The most severe form is caused by HANTAAN VIRUS whose natural host is the rodent Apodemus agrarius. Milder forms are caused by SEOUL VIRUS and transmitted by the rodents Rattus rattus and R. norvegicus, and the PUUMALA VIRUS with transmission by Clethrionomys galreolus.Mass Casualty Incidents: Events that overwhelm the resources of local HOSPITALS and health care providers. They are likely to impose a sustained demand for HEALTH SERVICES rather than the short, intense peak customary with smaller scale disasters.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Nucleic Acids: High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Illusions: The misinterpretation of a real external, sensory experience.DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Oligonucleotide Probes: Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.Tropical Medicine: The branch of medicine concerned with diseases, mainly of parasitic origin, common in tropical and subtropical regions.Enterotoxigenic Escherichia coli: Strains of ESCHERICHIA COLI that produce or contain at least one member of either heat-labile or heat-stable ENTEROTOXINS. The organisms colonize the mucosal surface of the small intestine and elaborate their enterotoxins causing DIARRHEA. They are mainly associated with tropical and developing countries and affect susceptible travelers to those places.Fimbriae Proteins: Proteins that are structural components of bacterial fimbriae (FIMBRIAE, BACTERIAL) or sex pili (PILI, SEX).Indonesia: A republic stretching from the Indian Ocean east to New Guinea, comprising six main islands: Java, Sumatra, Bali, Kalimantan (the Indonesian portion of the island of Borneo), Sulawesi (formerly known as the Celebes) and Irian Jaya (the western part of New Guinea). Its capital is Djakarta. The ethnic groups living there are largely Chinese, Arab, Eurasian, Indian, and Pakistani; 85% of the peoples are of the Islamic faith.Enterotoxins: Substances that are toxic to the intestinal tract causing vomiting, diarrhea, etc.; most common enterotoxins are produced by bacteria.Diarrhea: An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.Escherichia coli Infections: Infections with bacteria of the species ESCHERICHIA COLI.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.GermanyRed Cross: International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.Classification: The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Lentivirus: A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.Genetic Vectors: DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.Transduction, Genetic: The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.Cell Cycle: The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.Transgenes: Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.Gene Transfer Techniques: The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.Genetic Therapy: Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

Experimental infection of the cane mouse Zygodontomys brevicauda (family Muridae) with guanarito virus (Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. (1/73)

Chronic infections in specific rodents appear to be crucial to the long-term persistence of arenaviruses in nature. The cane mouse, Zygodontomys brevicauda, is a natural host of Guanarito virus (family Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. The purpose of this study was to elucidate the natural history of Guanarito virus infection in Z. brevicauda. Thirty-nine laboratory-reared cane mice each were inoculated subcutaneously with 3.0 log10 plaque-forming units of the Guanarito virus prototype strain INH-95551. No lethality was associated with infection in any animal, regardless of age at inoculation. The 13 newborn, 14 weanling, and 8 of the 12 adult animals developed chronic viremic infections characterized by persistent shedding of infectious virus in oropharyngeal secretions and urine. These findings indicate that Guanarito virus infection in Z. brevicauda can be chronic and thus support the concept that this rodent species is the natural reservoir of Guanarito virus.  (+info)

Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-alpha gene expression. (2/73)

Cells of the mononuclear and endothelial lineages are targets for viruses which cause hemorrhagic fevers (HF) such as the filoviruses Marburg and Ebola, and the arenaviruses Lassa and Junin. A recent model of Marburg HF pathogenesis proposes that virus directly causes endothelial cell damage and macrophage release of TNF-alpha which increases the permeability of endothelial monolayers [Feldmann et al. , 1996]. We show that Lassa virus replicates in human monocytes/macrophages and endothelial cells without damaging them. Human endothelial cells (HUVEC) are highly susceptible to infection by both Lassa and Mopeia (a non-pathogenic Lassa-related arenavirus). Whereas monocytes must differentiate into macrophages before supporting even low level production of these viruses, the virus yields in the culture medium of infected HUVEC cells reach more than 7 log10 PFU/ml without cellular damage. In contrast to filovirus, Lassa virus replication in monocytes/macrophages fails to stimulate TNF-alpha gene expression and even down-regulates LPS-stimulated TNF-alpha mRNA synthesis. The expression of IL-8, a prototypic proinflammatory CXC chemokine, was also suppressed in Lassa virus infected monocytes/macrophages and HUVEC on both the protein and mRNA levels. This contrasts with Mopeia virus infection of HUVEC in which neither IL-8 mRNA nor protein are reduced. The cumulative down-regulation of TNF-alpha and IL-8 expression could explain the absence of inflammatory and effective immune responses in severe cases of Lassa HF.  (+info)

Genetic diversity among Lassa virus strains. (3/73)

The arenavirus Lassa virus causes Lassa fever, a viral hemorrhagic fever that is endemic in the countries of Nigeria, Sierra Leone, Liberia, and Guinea and perhaps elsewhere in West Africa. To determine the degree of genetic diversity among Lassa virus strains, partial nucleoprotein (NP) gene sequences were obtained from 54 strains and analyzed. Phylogenetic analyses showed that Lassa viruses comprise four lineages, three of which are found in Nigeria and the fourth in Guinea, Liberia, and Sierra Leone. Overall strain variation in the partial NP gene sequence was found to be as high as 27% at the nucleotide level and 15% at the amino acid level. Genetic distance among Lassa strains was found to correlate with geographic distance rather than time, and no evidence of a "molecular clock" was found. A method for amplifying and cloning full-length arenavirus S RNAs was developed and used to obtain the complete NP and glycoprotein gene (GP1 and GP2) sequences for two representative Nigerian strains of Lassa virus. Comparison of full-length gene sequences for four Lassa virus strains representing the four lineages showed that the NP gene (up to 23.8% nucleotide difference and 12.0% amino acid difference) is more variable than the glycoprotein genes. Although the evolutionary order of descent within Lassa virus strains was not completely resolved, the phylogenetic analyses of full-length NP, GP1, and GP2 gene sequences suggested that Nigerian strains of Lassa virus were ancestral to strains from Guinea, Liberia, and Sierra Leone. Compared to the New World arenaviruses, Lassa and the other Old World arenaviruses have either undergone a shorter period of diverisification or are evolving at a slower rate. This study represents the first large-scale examination of Lassa virus genetic variation.  (+info)

Extreme genetic diversity among Pirital virus (Arenaviridae) isolates from western Venezuela. (4/73)

Pirital-like virus isolates from rodents collected in a variety of habitats within a six-state area of central Venezuela were analyzed genetically by amplifying a portion of the nucleocapsid protein gene using RT-PCR. Comparisons of the sequences from 30 selected Pirital-like virus isolates demonstrated up to 26% divergence in nucleotide sequences and up to 16% divergence in deduced amino acid sequences. Within the Pirital monophyletic group, 14 distinct lineages or genotypes, differing by at least 6% in nucleotide sequences, were identified. Although sample sizes were small for some lineages, many of the different genotypes were sampled in only one region or locality, suggesting allopatric divergence. Complement fixation tests with representatives of the most divergent Pirital virus lineages failed to delineate multiple species or subtypes within the Pirital clade. These results indicate that the previously proposed 12% nucleocapsid protein amino acid sequence divergence cutoff value for delineating arenavirus species is not appropriate for the entire family. When individual clones were examined from PCR amplicons, a mean of 0.17% sequence diversity vs the consensus sequences was detected, suggesting diverse quasispecies populations within infected rodent hosts. Possible explanations for the extreme genetic diversity within and among Pirital virus populations in infected rodents are discussed.  (+info)

Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections. (5/73)

Pichinde virus (PV) strain AN 3739 was determined to be sensitive to natural killer (NK) cells in vivo by enhanced replication in NK-cell-depleted mice. An NK-sensitive subclone (PV-NKs1) was serially passed in mice whose NK cells had previously been activated by an interferon inducer, and two plaque isolates were shown to be resistant to NK cells but not to interferon. Inoculation of severe-combined-immunodeficient mice with PV-NKs1 led to a persistent infection resulting in an NK-resistant viral population. This is the first demonstration of the isolation of viral "NK-escape" variants, as defined by the ability of the virus to replicate in vivo.  (+info)

Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. (6/73)

The receptor for lymphocytic choriomeningitis virus (LCMV), the human pathogenic Lassa fever virus (LFV), and clade C New World arenaviruses is alpha-dystroglycan (alpha-DG), a cell surface receptor for proteins of the extracellular matrix (ECM). Specific posttranslational modification of alpha-DG by the glycosyltransferase LARGE is critical for its function as an ECM receptor. In the present study, we show that LARGE-dependent modification is also crucial for alpha-DG's function as a cellular receptor for arenaviruses. Virus binding involves the mucin-type domain of alpha-DG and depends on modification by LARGE. A crucial role of the LARGE-dependent glycosylation of alpha-DG for virus binding is found for several isolates of LCMV, LFV, and the arenaviruses Mobala and Oliveros. Since the posttranslational modification by LARGE is crucial for alpha-DG recognition by both arenaviruses and the host-derived ligand laminin, it also influences competition between virus and laminin for alpha-DG. Hence, LARGE-dependent glycosylation of alpha-DG has important implications for the virus-host cell interaction and the pathogenesis of LFV in humans.  (+info)

Molecular organization of Junin virus S RNA: complete nucleotide sequence, relationship with other members of the Arenaviridae and unusual secondary structures. (7/73)

In this study, overlapping cDNA clones covering the entire S RNA molecule of Junin virus, an arenavirus that causes Argentine haemorrhagic fever, were generated. The complete sequence of this 3400 nucleotide RNA was determined using the dideoxynucleotide chain termination method. The nucleocapsid protein (N) and the glycoprotein precursor (GPC) genes were identified as two non-overlapping open reading frames of opposite polarity, encoding primary translation products of 564 and 481 amino acids, respectively. Intracellular processing of the latter yields the glycoproteins found in the viral envelope. Comparison of the Junin virus N protein with the homologous proteins of other arenaviruses indicated that amino acid sequences are conserved, the identity ranging from 46 to 76%. The N-terminal half of GPC exhibits an even higher degree of conservation (54 to 82%), whereas the C-terminal half is less conserved (21 to 50%). In all comparisons the highest level of amino acid sequence identity was seen when Junin virus and Tacaribe virus sequences were aligned. The nucleotide sequence at the 5' end of Junin virus S RNA is not identical to that determined of the other sequenced arenaviruses. However, it is complementary to the 3'-terminal sequences and may form a very stable panhandle structure (delta G-242.7 kJ/mol) involving the complete non-coding regions upstream from both the N and GPC genes. In addition, a distinct secondary structure was identified in the intergenic region, downstream from the coding sequences; Junin virus S RNA shows a potential secondary structure consisting of two hairpin loops (delta G -163.2 and -239.3 kJ/mol) instead of the single hairpin loop that is usually found in other arenaviruses. The analysis of the arenavirus S RNA nucleotide sequences and their encoded products is discussed in relation to structure and function.  (+info)

Receptor use by pathogenic arenaviruses. (8/73)

The arenavirus family contains several important human pathogens including Lassa fever virus (LASV), lymphocytic choriomeningitis virus (LCMV) and the New World clade B viruses Junin (JUNV) and Machupo (MACV). Previously, alpha-dystroglycan (alpha-DG) was identified as a receptor recognized by LASV and certain strains of LCMV. However, other studies have suggested that alpha-DG is probably not used by the clade B viruses, and the receptor(s) for these pathogens is currently unknown. Using pseudotyped retroviral vectors displaying arenavirus glycoproteins (GPs), we are able to explore the role played by the GP in viral entry in the absence of other viral proteins. By examining the ability of the vectors to transduce DG knockout murine embryonic stem (ES) cells, we have confirmed that LASV has an absolute requirement for alpha-DG in these cells. However, the LCMV GP can still direct substantial entry into murine ES cells in the absence of alpha-DG, even when the GP from the clone 13 variant is used that has previously been reported to be highly dependent on alpha-DG for entry. We also found that neither LASV or LCMV pseudotyped vectors were able to transduce human or murine lymphocytes, presumably due to the glycosylation state of alpha-DG in these cells. In contrast, the JUNV and MACV GPs displayed broad tropism on human, murine and avian cell types, including lymphocytes, and showed no requirement for alpha-DG in murine ES cells. These findings highlight the importance of molecules other than alpha-DG for arenavirus entry. An alternate receptor is present on murine ES cells that can be used by LCMV but not by LASV, and which is not available on human or murine lymphocytes, while a distinct and widely expressed receptor(s) is used by the clade B viruses.  (+info)

*Viral disease

"Arenaviridae". ViralZone. SIB Swiss Institute of Bioinformatics. Retrieved 2015-10-03. "Bunyaviridae". ViralZone. SIB Swiss ... Four families have segmented genomes: Bunyaviridae, Orthomyxoviridae, Arenaviridae and Reoviridae (acronym BOAR). All are RNA ... There are six negative single-stranded RNA families: Arenaviridae, Bunyaviridae, Filoviridae, Orthomyxoviridae, Paramyxoviridae ...

*Lymphocytic choriomeningitis

Viral Zone "Arenaviridae" Zhou, X; Ramachaundran, S; Mann, M; Popkin, DL (2012). "Role of Lymphocytic Choriomeningitis virus( ... Viral Zone "Arenaviridae". Hill, A. Edward (1948). "Benign lymphocytic meningitis". Caribbean Medical Journal. XI (1): 34-7. ... Its causative agent is the lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae. The name was coined ... Virus Pathogen Database and Analysis Resource (ViPR): Arenaviridae. ...

*Arenavirus

Viralzone: Arenavirus Detailed genomic and bioinformatic information about Arenaviridae at NIH-funded database. Arenaviridae ... Within the family Arenaviridae, arenaviruses were formerly all placed in the genus Arenavirus, but were recently (2014) ... An arenavirus is a virus which is a member of the family Arenaviridae. These viruses infect rodents and occasionally humans; ... Virus Pathogen Database and Analysis Resource (ViPR): Arenaviridae Arenaviruses "Arenavirus". NCBI Taxonomy Browser. 11618. ...

*Lassa fever

The Lassa virus is a member of the Arenaviridae virus family. There is no vaccine. Prevention requires isolating those who are ...

*Robovirus

Lassa virus from the Arenaviridae family causes Lassa Hemorrhagic fever and is also a robovirus transmitted by the rodent genus ... Roboviruses mainly belong to the Arenaviridae and Hantaviridae family of viruses. Like arbovirus (arthropod borne) and ...

*10924 virus

The 10924 virus is a strain of Latino virus, of family Arenaviridae. Mahy, Brian W J (2001). A dictionary of virology (3. ed ...

*12056 virus

The 12056 virus is a strain of Paraná virus, of family Arenaviridae. It is also referred to as Tobacco necrosis virus (type D ...

*Whitewater Arroyo virus

Family: Arenaviridae Genus: Mammarenavirus Species: Whitewater Arroyo mammarenavirus WWAV is an emerging virus; previously, it ...

*Negative-sense single-stranded RNA virus

Lassa virus (Arenaviridae) Lymphocytic choriomeningitis virus (Arenaviridae) Hantavirus (Bunyaviridae) Marburg Virus ( ... Arenaviridae- contain genomes of six to eight, three, or two negative-sense RNA segments, respectively. Many highly prevalent ... Family Arenaviridae - includes Lassa virus Family Ophioviridae Family Orthomyxoviridae - includes Influenza viruses Unassigned ... genera: Genus Deltavirus - includes Hepatitis D virus Unassigned species: Taastrup virus Viruses of the families Arenaviridae, ...

*Flexal mammarenavirus

It is a member of Clade A of the Tacaribe (or "New World") serocomplex of the family Arenaviridae. Laboratory workers infected ...

*Baltimore classification

Examples in this class include the families Arenaviridae, Orthomyxoviridae, Paramyxoviridae, Bunyaviridae, Filoviridae, and ...

*Lujo virus

Viruses from the Arenaviridae family, to which Lujo virus belongs, almost always have a rodent reservoir, with one virus in the ... Lujo is a bisegmented RNA virus-a member of the family Arenaviridae-and a known cause of viral hemorrhagic fever (VHF) in ...

*Bolivian hemorrhagic fever

BHF was first identified in 1963 as an ambisense RNA virus of the Arenaviridae family, by a research group led by Karl Johnson ...

*Virus Pathogen Database and Analysis Resource

The ViPR database includes genomes from these viral families: Arenaviridae, Bunyaviridae, Caliciviridae, Coronaviridae, ...

*Quaranjavirus

I. Evidence suggesting the placement of viruses in families Arenaviridae, Paramyxoviridae, or Poxviridae" (PDF), Archives of ... 2006), "Index of Viruses - Arenaviridae", ICTVdB - The Universal Virus Database, version 4, Columbia University, retrieved 16 ...

*Taxonomic list of viruses

Arenaviridae Genus: Mammarenavirus Allpahuayo mammarenavirus Amaparí mammarenavirus Bear Canyon mammarenavirus Chapare ...

*Viral Bioinformatics Resource Center

The VBRC covers the following viruses under its NIAID mandate:[citation needed] Arenaviridae Bunyaviridae Filoviridae ...

*List of MeSH codes (B04)

... arenaviridae MeSH B04.909.777.080.070 --- arenavirus MeSH B04.909.777.080.070.100 --- arenaviruses, old world MeSH B04.909. ...

*RNA virus

Arenaviridae) Lymphocytic choriomeningitis virus (Arenaviridae) Hantavirus (Bunyaviridae) Marburg Virus (Filoviridae) Ebola ... Family Arenaviridae - includes Lassa virus Family Ophioviridae Family Orthomyxoviridae - includes Influenza viruses Unassigned ...

*List of virus families and subfamilies

Alphaflexiviridae Alphaherpesvirinae Alphatetraviridae Alvernaviridae Amalgaviridae Ampullaviridae Anelloviridae Arenaviridae ...

*C. J. Peters

Arenaviridae (Lassa fever, South American hemorrhagic fevers) and SARS CoV. He runs an active program of human and animal ...
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Pichinde virus (PIC) is a reticuloendothelial arenavirus of the New World tropics. A guinea pig passage-adapted strain of this virus (adPIC) is uniformly lethal for inbred guinea pigs, while the related, prototype strain (PIC3739) has attenuated virulence. The abilities of adPIC and PIC3739 to induce tumor necrosis factor (TNF) in vivo and in cultured macrophages were compared. Infection with adPIC, but not PIC3739, was associated with detectable serum TNF that peaked in week 2 of infection. Tumor necrosis factor was found in the spleens of adPIC- and PIC3739-infected animals in week 1 of infection ; TNFα mRNA levels in spleens and livers of adPIC infected animals increased and remained high throughout infection, whereas PIC3739-infected organs showed down regulation of TNFα mRNA late in infection. Peritoneal macrophages explanted from adPIC-infected animals showed enhanced lipopolysaccharide-inducible TNF production. Altered regulation of TNF production may play a role in the pathogenesis of guinea
The established animal model for Lassa fever is based on the new world arenavirus Pichinde (PIC). Natural isolates of PIC virus are attenuated in guinea pigs, but serial guinea pig passage renders them extremely virulent in that host. We have compared the nucleotide sequences of the small RNA segments of two attenuated, low-passage variants of the PIC virus Munchique strain (CoAn 4763) and two virulent, high-passage derivatives. Missense mutations in the glycoprotein precursor (GPC) gene at codons GPC-119, GPC-140, and GPC-164 and the nucleoprotein gene (NP) codons NP-35 and NP-374 were most closely associated with virulence. Codon GPC-140 is predicted to represent a region of peak hydrophilicity of the glycoprotein 1 (GP1); it is conceivable that mutations at this site could influence virulence by altering B cell epitopes or virus attachment protein conformation.
We have investigated the double-layered carbon nano-onions (CNOs) C₂₀@C₆₀, C₂₀@C₈₀, C₆₀@C₁₈₀, C₆₀@C₂₄₀, C₈₀@C₂₄₀, and C₂₄₀@C₅₄₀ as well as their triple-layered analogues C₆₀@C₂₄₀@C₅₄₀ and C₈₀@C₂₄₀@C₅₄₀ with high-level electronic structure calculations. We were able to show that earlier work, which showed the free rotation of the inner fullerene in a CNO, does not extend to multilayered CNOs. We sh ...
Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean?
Two days after infecting groups of guinea pigs with a lethal dose of Lassa virus, the scientists treated the rodents daily for two weeks with either ribavirin, low doses of favipiravir, or high doses of favipiravir. They also evaluated the effect of high-dose favipiravir in the rodents that began treatment five, seven or nine days after infection. All of the animals that received high-dose favipiravir were completely protected from lethal infection; animals treated seven or nine days after infection had begun showing signs of disease, but their conditions quickly improved when treatment began. Those animals in the low-dose favipiravir group showed mild to moderate signs of disease, but those symptoms resolved after about one week of treatment. The animals treated with ribavirin appeared normal during the treatment phase but developed severe disease shortly after treatment ended. ...
Lassa fever is an acute viral haemorrhagic illness of 1-4 weeks duration that occurs in West Africa. Lassa Fever, Lassa Fever Symptoms, Lassa Fever Prevention
Lassa fever is an acute viral haemorrhagic illness of 1-4 weeks duration that occurs in West Africa. Lassa Fever, Lassa Fever Symptoms, Lassa Fever Prevention
Lassa Virus Essay, Research Paper The Lassa virus is a vulgar virus with a high mortality rate and an expensive cure. Lassa was strange to me because I have never heard of the virus before. As I was reading in my research, I began to realize the risk the virus has on people.
Virulent and highly transmissible member of the Arenaviridae whose normal host is a rodent (Mastomys natalensis ) ; first recorded from Nigeria
Researchers have uncovered structural and functional details of a key Lassa virus protein; this new information may aid the development of vaccines.
Looking for Guanarito virus? Find out information about Guanarito virus. parasite with a noncellular structure composed mainly of nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living... Explanation of Guanarito virus
According to a release issued in Monrovia, from January 1, 2019 to December 31, 2019, NPHIL, through the National Reference Laboratory, recorded 50 confirmed cases of Lassa fever. Of the 50 cases, 18 deaths were recorded, a Case Fatality Rate (CFR) of 36%. This 2019 CFR is a significant improvement compared to the 2018 CFR of 66%.. In view of the aforementioned recent Lassa fever cases, and the fact that NPHIL has responded to an average of one Lassa fever case per week in recent months, NPHIL, in collaboration with the Ministry of Health, has deemed it expedient to announce that Liberia has had a continuous Lassa fever outbreak.. The release also disclosed that although Lassa fever is not new to Liberia, it is a potentially deadly viral disease that requires urgent attention. The disease is spread by rodents or rats and through close contact with affected persons. Lassa fever is not as infectious as Ebola and rarely spread from persons to persons. However, health workers, communities, and the ...
To determine whether Lassa virus was circulating in southern Mali, we tested samples from small mammals from 3 villages, including Soromba, where in 2009 a British citizen probably contracted a lethal Lassa virus infection. We report the isolation and genetic characterization of Lassa virus from an area previously unknown for Lassa fever.
Argentine hemorrhagic fever (AHF) was recognized as a new clinical entity from the richest farming region of Argentina in the 1950s (Arribalzaga 1955). The etiologic agent of this disease, Junin virus
Los síndromes infecciosos asociados a arenavirus en América del sur son cuatro: síndrome febril de origen viral; fiebres hemorrágicas con o sin compromiso neurológico; meningitis asépticas y meningo-encefalitis. Entre los Arenavirus del nuevo mundo, está el complejo Tacaribe donde se encuentran los virus: Junín (Argentina), Guanarito (Venezuela), Machupo (Bolivia) y Sabiá (Brasil), que se caracterizan por causar fiebres hemorrágicas. En Colombia fue aislado el arenavirus Pichindé en 1965, del roedor Oryzomys albigularis, en el valle de Pichindé (Valle del Cauca). Este arenavirus produce una infección persistente en su hospedero y no es patógeno para el hombre. Hay evidencias de la circulación del virus Guanarito en roedores de Córdoba, pero no existen casos diagnosticados en humanos; en Sincelejo (Colombia) se detectó el genoma del virus coriomeningitis linfocítica en cerebros de roedores Mus musculus. El diagnóstico se basa en el conocimiento de la epidemiología local y la sospecha
The study set to assess the knowledge and attitude to Lassa fever among primary care providers. Structured questionnaires were administered to consenting primary care workers in Private and Primary health centres in Ekpoma. Data analysis was carried out using SPSS version 15. One hundred and thirty five (135) health workers participated in the study. One hundred and thirty one (97.0%) respondents had previously heard of Lassa fever. Overall knowledge of Lassa fever was poor for 51 (38.9%), and fair for 54 (41.2%) and good for 260 (19.8%). Hand gloves were stated as the most useful personal protective gear when dealing with a patient with Lassa fever. Fifty six (42.7 %) felt their level of knowledge was sufficient for them to safely and effectively handle a patient, 126 (96.4%) expressed their desire to know more about Lassa fever. The primary care health worker in a rural area is the one most likely to be the first point of call for persons seeking orthodox medicine. It is therefore essential ...
The first case of the current outbreak was reported from Bauchi in November, 2015. This was followed by cases reported by Kano State, and subsequently the other states mentioned above. "Lassa fever is an acute febrile illness, with bleeding and death in severe cases, caused by the Lassa fever virus with an incubation period of 6-21 days. Lassa fever was first detected in Nigeria in 1969.The number of recorded cases peaked in 2012 when 1,723 cases with 112 fatalities were recorded. It has continued to decline since then ...
Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. The majority of these viruses are rodent-borne and the arenavirus family can be divided into two groups: the Lassa-Lymphocytic choriomeningitis serocomplex and the Tacaribe serocomplex. Arenavirus-induced disease may include characteristic symptoms ranging from fever, malaise, body aches, petechiae, dehydration, hemorrhage, organ failure, shock, and in severe cases death. Currently, there are few prophylactic and therapeutic treatments available for arenavirus-induced symptoms. Supportive care and ribavirin remain the predominant strategies for treating most of the arenavirus-induced diseases. Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. Because of the potential for person-to-person spread, the ability to cause lethal or debilitating disease in humans,
Junin virus buds at CD9-enriched sites. JUNV-A647 viral particles stained with either a CD9 antibody conjugated to PE (a) or Cholera Toxin B (CTB) conjugated to
BACKGROUND INFORMATION ABOUT CONVALESCENT PLASMA: Passive immunity has proven effective for cytomegalovirus (CMV), hepatitis B virus, rabies, tetanus, varicella, certain SARS variants, Argentine Hemorrhagic Fever, and various other illnesses. Convalescent plasma has been cited as a potential therapy for viral infection dating back to the 1918 Spanish influenza A (H1N1) pandemic. Since that time, convalescent plasma as passive immune therapy has been evaluated in the treatment of: Ebola, SARS coronavirus (SARS-CoV), 2009 pandemic influenza A (H1N1), Argentine Hemorrhagic Fever, CMV, Parvovirus B19, and others. Furthermore, a February 2020 WHO report states "The cellular infectivity of the isolated viruses could be completely neutralized by the sera collected from convalescent patients." [Source: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf ] ABOUT CERUS Cerus Corporation is dedicated solely to safeguarding the worlds blood supply and ...
Funmi,. Its good to be loyal. But when lives are being lost, let us call a spade a spade. MOH has been deafeningly silent on Lassa Fever. Not the same as when Ebola was the issue. HEre is why a lot of noise is good around Lassa fever. First, it will keep the masses on the alert. Second, it will ensure dissemination of public health messages about symptoms, what to do when you have symptoms. Three, it will alert the medical community from doctors to nurses. Four, it will foster discussions at state and local levels about allocation of resources specially for this issue. Now, what is the role of the feds? The role of the federal government led by PMB and his minister for health is to initiate this communication action plan, define a coordinating strategy for collecting surveillance data (a key element in owning and subduing epidemics), set up a coordination strategy that is known to health officials, other officials and the general public, ascertain where resources are needed, and mobilize ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
Key facts Lassa fever is an acute viral hemorrhagic illness, with a duration of 1-4 weeks duration that occurs in West Africa. The Lassa virus is transmitted to humans via contact with food or household items contaminated with rodent urine or faeces. Person-to-person infections and laboratory transmission can also
Kayode Idowu, Maiduguri Twenty persons have been quarantined in Borno State as Lassa fever spread to the state. Briefing newsmen on Wednesday in ...
The death toll from a Lassa fever outbreak in northern Nigeria has risen to 41, the Nigeria Center for Disease Control announced this week.
Ebola also claimed victims in Nigeria...and the government there won plaudits for quickly containing the outbreak. Now though another virus is spreadi...
This is the first case of Lassa fever to be imported from Mali to the United Kingdom. This paper discusses the investigations, the virological analysis, the surveillance and management of contacts undertaken following a case of Lassa fever.
Lassa virus belongs to the Arenaviridae family and causes Lassa fever, also known as Lassa haemorrhagic fever (LHF). It is a haemorrhagic illness that occurs between one and three weeks after infection.. Lassa fever is a zoonotic disease, meaning it passes from animals to humans. The natural host of Lassa virus is the rodent Mastomys natalensis, otherwise known as the Natal multimammate mouse or rat.. The virus is spread when a person comes into contact with items contaminated with the rodents urine or faeces - for example, by handling objects, eating or through open wounds. It can also be inhaled.. Lassa virus can pass from person to person via bodily fluids, and can spread in healthcare settings if suitable precautions are not taken.. ...
Lassa fever has killed 100,000 Nigerians - Expert. Prof. Dennis Agbonlahor, a member of the National Committee on the Control of Lassa fever, says the virus had killed more than 100,000 Nigerians since the discovery of the virus in the country, calling for more funding and political will to combat the scourge.. Agbonlahor said this while presenting a paper titled "Combating Lassa fever: A National Health Challenge", organised by the University of Benin on Friday in Benin.. The expert therefore, commended the Federal Government for creating moreawareness about the disease calling for sustenance of the awareness initiative.. Also, he applauded the trials of newly developed Lassa virus vaccine in the country.. He said that the vaccine developed by a combined team from the U.S. Army Medical Research Institute for Infectious Diseases and the Public Health Agencies of Canada was a promising vaccine for controlling Lassa fever.. According to him, "this live and harmless vaccine, which is wrapped in a ...
Neighbor-joining phylogenetic tree of Machupo virus derived from the glycoprotein precursor gene sequence. The neighbor-joining and maximum likelihood analyses
Explanation:. Lassa fever or Lassa hemorrhagic fever (LHF) is caused by Lassa virus. This disease is mainly prevalent in West Africa countries such as Nigeria, Liberia, Sierra Leone, Guinea, and Ghana. It results in 5000 deaths every year. Its a zoonotic disease transmits to human from a species of mouse. ...
Two persons, including a 36-year-old pregnant woman, have died at the Lagos University Teaching Hospital, LUTH, Idi-Araba, after being treated for Lassa fever.. Also, not less than 100 different hospital workers, who were exposed to the index case, including a resident doctor from the Department of Anatomic and Molecular Pathology are currently under close observation in LUTH, THISDAY investigations have shown.. The resident doctor was said to have taken part in the autopsy of the late pregnant woman. He is currently at the surveillance unit of the hospital, where he is being treated.. The Chief Medical Director, LUTH, Prof. Chris Bode, told THISDAY that the two patients died within a few days of admission as they presented late to the hospital in spite of efforts of the health workers to save their lives, adding that the late pregnant womans post-mortem examination was conducted before her Lassa fever status was eventually suspected and confirmed.. "The Centre for Disease Control (CDC) in ...
FBI will investigate the Texas biolab where a deadly virus went missing, according to the Centers for Disease Control and Prevention.
According to him, "we demonstrated and emphasised to the general public that all it takes to see a doctor is simply the decision to do so; we also organised a press conference on Lassa fever outbreak and in liaison with other stakeholders, ensured that Enugu State was Lassa free, while our committee on hemorrhagic fever worked closely with the state ministry of health and management of all hospitals to fight Lassa.". He also disclosed that the association was actively involved in the fight against quacks and impersonation of the medical profession by disgruntled elements, adding that the leadership during the period launched into the radio and TV waves, jingles on the best way to assess quality health care services and the need to make a qualified medical doctor the point of call on health issues.. He recalled that during their courtesy visit to the Enugu State Governor, Hon. Ifeanyi Ugwuanyi, at the Government House, the NMA handed a framework document on the road map towards effective health ...
VHFC partner, Corgenix Medical Corporation, has developed the first commercialized diagnostic test that enables rapid diagnosis of Lassa viral hemorrhagic fever.. "This 15-minute test has the potential to completely change stye way Lassa fever is detected and treated," said Douglas Simpson, Corgenix President.. Read the full press release on the Corgenix website. ...
The Ogun State Commissioner for Health, Babatunde Ipaye has confirmed the outbreak of Lassa fever saying a 20-year-old patient tested positive for the virus and has been moved to one of the isolation centres set up by the state government ...
Samuel Awoyinfa, Tobi Aworinde, Bukola Bakare and Joy Marcus There is palpable fear in Ogun State over a suspected case of Lassa fever in the stat...
Adamawa State has recorded its first case of death from Lassa Fever. The victim, a personnel of the Nigerian Security and Civil Defense Corps (NSCDC) identified as Gabriel Ambe, serving in Gembu, Taraba, is said to have died on Thursday at the Federal Medical Centre in Yola.
A team of British experts is being sent to Nigeria to help the country contain the biggest outbreak of Lassa fever in recent years.
Dr. Idris is a famous health specialist, There were some controversies came up on their hospital but he refused all the controversies and clearly stated that lassa fever patients will get recovered soon by the treatment of his hospital.. ReplyDelete ...
Ebola virus disease (EVD) is a dreaded viral disease and the first case of the virus was recorded in 1976 in Zaire which was where it g ...
For 2016, EU/EEA countries reported three cases of Lassa fever. Germany reported two cases, and Sweden reported one case. These were the first Lassa fever cases reported by EU/EEA countries since 2009 when two cases were reported by the United Kingdom. ...
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Lassa fever is a severe and often fatal hemorrhagic illness caused by Lassa virus. Since its original discovery in 1969 in the village of Lassa in Borno State, Nigeria, there have been countless outbreaks of various magnitude and severity across West Africa. Estimates of annual incidences of Lassa fever across this region reach as high as 300,000 infections and 5,000 deaths. However due to scarce resources to diagnose the illness as well as inadequate surveillance, many cases remain unaccounted.. Lassa virus is a member of the Arenaviridae virus family. Humans contract the virus primarily through contact with the contaminated excreta of Mastomys natalensis rodents (commonly known as the Multimammate rat), which is the natural reservoir for the virus. Little is known regarding the transmission of the virus from the rodent reservoir to the human host, although there is compelling evidence that Arenaviruses are stable and infectious by the aerosol route in nonhuman primates. The rodents live in ...
All You Need To Know About Lassa Fever (Transmission, Signs And Symptoms, Prevention Treatment). Lassa fever is an acute viral illness caused by the Lassa virus; it was first discovered in 1969 in the town of Lassa, in Borno State, Nigeria, when two missionary nurses died. The virus, a member of the virus family Arenaviridae, is a single stranded RNA virus and is zoonotic, or animal borne.. The endemic disease which has in the past days killed more than 40 people in Nigeria has a broadened geographic ambit in West Africa as it is recognized in Guinea, Liberia and Sierra Leone, due to the nature of the rodent species, inhabiting these regions.. While divulging the death toll, It should be noted that Nigerias Health Minister Isaac Adewole on Friday Januray 8, 2016 said that seven of the affected states are in the north - Bauchi, Nasarawa, Niger, Taraba, Kano, Plateau and Gombe - while the remaining three are in the south - Rivers, Edo and Oyo.. The host of Lassa virus is a rodent known as the ...
The federal government yesterday called on Nigerians to desist from self-medication especially fever related ailments to check the spread of Lassa fever.. Coordinator, Nigeria Centre for Disease Control (NCDC), Dr Chikwe Ihekweazu stated this yesterday at a workshop on Management and control of Lassa fever and other viral hemorrhagic fevers organised by the Irrua Specialist Teaching Hospital (ISTH), Irrua in Edo State, where he called on Nigerians to always see the need to get a diagnosis and desist from self medication to prevent serious illnesses.. He also commended ISTH in their efforts in engaging and supporting the communities affected with lassa fever, describing them as a leader in the diagnosis, care and management of patients with the fever.. The Chief Medical Director of ISTH, Dr. Sylvanus Okogbenin stated that the ISTH has built substantial capacity and gathered enormous experience in the management and control of lassa fever, noting that since the establishment of the molecular ...
It will be recalled that in May, 2016, the World Health Organisation, WHO, put the total cases of Lassa fever in Nigeria at 273 including 149 deaths between August 2015 and May 17, 2016.. With the recent outbreak in parts of the country, a breakdown shows that since August 2015, 12 health care workers have been infected with the Lassa fever virus, of which four have died.. Nigeria currently has two national laboratories supporting the laboratory confirmation preocedure of Lassa fever cases using the polymerase chain reaction (PCR) tests. All samples were also tested for Ebola, Dengue, and Yellow fevers and so far have been negative. The two laboratories currently operational are the Virology laboratory, Lagos University Teaching Hospital, LUTH.". In a statement, the Chief Executive Officer, Nigeria Centre for Disease Control, NCDC, Dr. Chikwe Ihekweazu said early detection and reporting of cases significantly improves the likelihood of survival for the cases and also reduces the risk of further ...
The structure reveals how the virus evades its hosts immune system, and how it hijacks infected cells vital machinery in a process scientists call "cap-stealing". Details of the structure could guide future efforts to develop an effective anti-viral drug and vaccine.. The findings are published in this weeks issue of Nature.. Lassa virus represents a family of viruses - arenaviruses - whose natural hosts are rodents and which cause hemorrhagic fevers in Africa and South America. New varieties of arenavirus continue to emerge, such as the deadly "Lujo" virus identified recently in Zambia and South Africa.. Lassa virus infects between 100,000 and 300,000 people every year in West Africa, with an estimated 5,000 deaths according to the Centres for Disease Control and Prevention. Most people infected experience a mild illness, but about 20 per cent suffer a severe multisystem disease with internal bleeding and immune suppression. Around one per cent of all infections are fatal. A common ...
As Lassa fever outbreak resurfaced in Lagos State, the state chapter of the Nigerian Medical Association has called for more public enlightenment and personal hygiene to prevent the spread of the disease.. A factional Chairman of NMA, Dr. Olubunmi Omojowolo, made the call in an interview with theNews Agency of Nigeria on Wednesday in Lagos.. Omojowolo was reacting to the death of two Lassa fever patients on Tuesday at the Lagos University Teaching Hospital, Idi-Araba, Lagos, while a resident doctor at the hospital has tested positive to the infectious disease.. The Chief Medical Director of LUTH, Prof. Chris Bode, confirming the reports on Tuesday, said no fewer than 100 health workers exposed to the index cases were currently being monitored.. Each of the two patients presented very late and died in spite of efforts to salvage them.. "The first was a 39-year old pregnant lady with bleeding disorder who died after a stillbirth.". "A post-mortem examination had been conducted before her Lassa ...
Davies J, Lokuge K, Glass K. Vaccine 37(26):3451-3456, 2019; 10.1016/j.vaccine.2019.05.010. Lassa fever is an acute viral illness caused by Lassa virus (LASV), a rodent-borne pathogen. LASV is endemic to much of Sub-Saharan West Africa, where seasonal outbreaks cause significant morbidity and mortality. Increased global awareness of LASV has led to development of improved diagnostic tests, treatments and vaccines. As vaccine candidates are trialled, it is essential to assess the potential outcomes of introducing a LASV vaccination program in endemic regions. This study investigates the potential outcomes of routine and pulse vaccination strategies using a deterministic mathematical model that captures seasonal LASV transmission between rodents and humans. For plausible parameter values, we find that immunization of 40% of infants at 70% vaccine effectiveness achieves a population-level reduction in infectious case numbers of 30%, while coverage of 60% at 90% vaccine effectiveness achieves a 56% ...
The Kastina state Commissioner of Health, Mariyatu Bala Usman has disclosed that a middle-aged man (name withheld), brother of a man who died from Lassa fever and seven others who participated in the burial rites have tested positive to Lassa fever in Kastina State, Northwest Nigeria.. They are now being quarantined at the National Obstetric Fistula Centre at Babbar Ruga.. The Director of Public Health, Dr. Shamsudden Yahaya said that about 18 primary contacts of the diseased had been quarantined just as over 100 secondary contacts were closely being monitored and are on drugs.. ...
Im finding out so much. The vaccine for Argentine Hemorrhagic Fever was created by Julio Barrera Oro in 1985. This virus kills about 30 % of the people that contract it and is spread by contact with the droppings of a small mouse. When the virus was isolated, almost simultaneously by two opposing institutions in Buenos Aires, the competition for who found it first was so severe that Julio Barrera Oro inoculated himself with this potentially lethal virus to show his team really had found it. A few days later he developed the fever. Luckily he survived ...
These Pathogen Safety Data Sheets, regulated under Workplace Hazardous Materials Information System (WHMIS) legislation, are produced for personnel working in the life sciences as quick safety reference material relating to infectious micro-organisms.
Supplementary Materials1: Notice: Supplementary information is usually available on the Nature Medicine website. guinea pigs recovered. They gained excess weight and within weekly lacked physical signals of disease, and had been healthy on time 135 once the tests had been terminated (Fig. 2a). This is actually the first report of the healing effective against advanced Pichinde disease infections. 14 d after illness, disease loads decreased in blood, spleen, lung, liver, kidney and heart from bavituximab-treated guinea pigs compared to control Ig-treated animals (Fig. 2b). Decreases in disease load were not seen before day time 14 (Supplementary Fig. 2 on-line). By day time 135, the bavituximab-treated survivors experienced completely cleared disease from their cells (not demonstrated). Combining bavituximab and ribavirin (the drug of choice for treating Lassa fever) experienced additive activity, as expected for medicines with nonoverlapping mechanisms of action. With the combined treatment, 63% ...
Lymphocytic Choriomeningitis (LCM) Lymphocytic choriomeningitis, or LCM, is a rodent-borne viral infectious disease caused by lymphocytic choriomeningitis virus (LCMV), a member of the family Arenaviridae that was initially isolated in 1933. The primary host of LCMV is the common house mouse, Mus musculus. Infection in house mouse populations may vary by geographic location, though it is estimated that 5% of house mice throughout the United States carry LCMV and are able to transmit virus for the duration of their lives without showing any sign of illness. Other types of rodents, such as hamsters, are not the natural reservoirs but can become infected with LCMV from wild mice at the breeder, in the pet store, or home environment. Humans are more likely to contract LCMV from house mice, but infections from pet rodents have also been reported.. LCMV infections have been reported in Europe, the Americas, Australia, and Japan, and may occur wherever infected rodent hosts of the virus are found. The ...
Standardization of an ELISA test using a recombinant nucleoprotein from the Junin virus as the antigen and serological screening for arenavirus among the population of Nova Xavantina, State of Mato Grosso ...
A major extension in the collaborative effort between Corgenix Medical Corporation and Tulane University has been announced to combat viral hemorrhagic fever.
TIRED OF READING NEWS ONLINE? GET THE APP HERE A university lecturer, Prof. Christian Happi, has claimed that Yoruba people, by the make-up of their genes, are immune to Lassa virus that causes Lassa fever. The researcher, who is Dean, College of Postgraduate Studies, Department of Biological Sciences, Redeemers University, Ede, Osun State, said research […]. ...
Image courtesy of Sreejithk2000, a Wikimedia Commons user The hemorrhagic fever viruses are a genetically diverse group and include Ebola, Marburg, Lassa, Hantavirus and others. They all have the same gross, even horrifying, symptoms - most notably, blood vessel damage leading to bleeding in internal organs and, in some cases, out of orifices. An article recently published in the journal Molecular & Cellular Proteomics reports molecular events throughout the course of infection in a model of hemorrhagic fever virus infection in hamsters. Understanding how cell-signaling networks change over the course of infection in this rodent virus, says Jason Kindrachuk, a staff scientist at the National Institutes of Health and corresponding author of the study, says could be a vital first step in the development of therapies for related viruses.. But, you might be wondering, what do hamsters have to do with Ebola and other hemorrhagic fever viruses? Pichinde virus is endemic to Colombian rice rats and ...
GERMANTOWN, MD - 17 Jul, 2017 - Zalgen Labs, LLC (Zalgen), a biotechnology and diagnostics company focused on high-impact, neglected infectious diseases including Lassa Fever (LF) and Ebola Viral Disease (EVD), today announced that Tulane University has been awarded two five-year awards to address Lassa Fever (LF). The grants totaling $12 million to Tulane, Zalgen, The Scripps Research Institute, the University of Texas Medical Branch at Galveston, and the Sanford Burnham Prebys Medical Discovery Institute, were awarded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIAID/NIH).. The immunotherapeutic grant will be used to complete the preclinical testing of Arevirumab-3, a proprietary immunotherapeutic cocktail developed by Zalgen to combat Lassa Fever. Arevirumab has already demonstrated 100 percent efficacy in treating infected animals using two relevant model systems. Following completion of the preclinical studies, the therapeutic is ...
GERMANTOWN, MD - 17 Jul, 2017 - Zalgen Labs, LLC (Zalgen), a biotechnology and diagnostics company focused on high-impact, neglected infectious diseases including Lassa Fever (LF) and Ebola Viral Disease (EVD), today announced that Tulane University has been awarded two five-year awards to address Lassa Fever (LF). The grants totaling $12 million to Tulane, Zalgen, The Scripps Research Institute, the University of Texas Medical Branch at Galveston, and the Sanford Burnham Prebys Medical Discovery Institute, were awarded by the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (NIAID/NIH).. The immunotherapeutic grant will be used to complete the preclinical testing of Arevirumab-3, a proprietary immunotherapeutic cocktail developed by Zalgen to combat Lassa Fever. Arevirumab has already demonstrated 100 percent efficacy in treating infected animals using two relevant model systems. Following completion of the preclinical studies, the therapeutic is ...
Definition of arenavirus - any of a group of RNA viruses (including that causing Lassa fever) that appear under an electron microscope to contain granules th
Via the Daily Trust: Ondo Lassa fever confined to single LG. Outbreak of Lassa fever has been confined to a single local government area, Ose, according to local health workers. Since January at least nine cases, including a police officer,...
Junín virus, the etiological agent of Argentine hemorrhagic fever, causes significant morbidity and mortality. The virus is spread through the aerosolization of host rodent excreta and endemic to the humid pampas of Argentina. Recently, significant progress has been achieved with the development of new technologies (e.g. reverse genetics) that have expanded knowledge about the pathogenesis and viral replication of Junín virus. We will review the pathogenesis of Junín virus in various animal models and the role of innate and adaptive immunity during infection. We will highlight current research regarding the role of molecular biology of Junín virus in elucidating virus attenuation. We will also summarize current knowledge on Junín virus pathogenesis focusing on the recent development of vaccines and potential therapeutics.
Ebonyi state commissioner for Health, Dr. Daniel Umezuike, says that 76 persons have died of Lassa fever and cholera in 38 communities in 11 local government areas of Ebonyi state.. He said that the diseases usually re-occur on a regular basis in the dry season.. He also announced that the state government has mandated the ministry to upgrade 171 primary Health centres, starting with 65 in five per Local Government Areas and to ensure the construction of the state drug distribution centers.. ...
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In January 2009, the eleventh case of Lassa fever imported to the United Kingdom was diagnosed in London. Risk assessment of 328 healthcare contacts with potential direct exposure to Lassa virus - through contact with the case or exposure to bodily fluids - was undertaken. No contacts were assessed to be at high risk of infection and no secondary clinical cases identified.
RN [1] RM PMID:20862324 RT The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription. RA Morin B, Coutard B, Lelke M, Ferron F, Kerber R, Jamal S, Frangeul A, Baronti C, Charrel R, de Lamballerie X, Vonrhein C, Lescar J, Bricogne G, Gunther S, Canard B RL PLoS Pathog. 2010 Sep 16;6(9):e1001038 ...
An acute viral illness of the arenavirus family. A disease native to West Africa, Lassa Fever is endemic in Guinea, Liberia, Sierra Leone and Nigeria. L...
Plays a crucial role in virion assembly and budding. Expressed late in the virus life cycle, it acts as an inhibitor of viral transcription and RNA synthesis by interacting with the viral polymerase L (By similarity). Presumably recruits the NP encapsidated genome to cellular membranes at budding sites via direct interaction with NP. Plays critical roles in the final steps of viral release by interacting with host TSG101, a member of the vacuolar protein-sorting pathway and using other cellular host proteins involved in vesicle formation pathway. The budding of the virus progeny occurs after association of protein Z with the viral glycoprotein complex SSP-GP1-GP2 at the cell periphery, step that requires myristoylation of protein Z. Also selectively represses protein production by associating with host eIF4E.
Boid inclusion body disease (BIBD) is a viral disease of boid snakes believed to be caused by reptarenavirus belonging to the family Arenaviridae. Unlike most mammalian arenaviruses, the reservoir host for reptarenavirus is still unknown. In this study, the pathological responses were evaluated in a mouse model for a period of 28 days. Blood and tissue samples (lung, liver, spleen, heart, kidney and brain) were collected for evaluation of hematology, biochemistry, histopathology and oxidative enzyme levels at six time points (1, 3, 7, 14, 21 and 28 days), after viral infection (2 ...
A group of 10 American healthcare workers who may have been exposed to the Ebola virus in Sierra Leone are being flown back to United States for monitoring, CDC officials said.
Viral hemorrhagic fevers (VHF) are acute zoonotic diseases that, early on, seem to cause platelet destruction or dysfunction. Here we present the four major ways viruses affect platelet development and function and new evidence of molecular factors that are preferentially induced by the more pathogenic members of the families Flaviviridae, Bunyaviridae, Arenaviridae, and Filoviridae. A systematic search was performed through the main medical electronic databases using as parameters all current findings concerning platelets in VHF. Additionally, the review contains information from conference proceedings ...
From 1 January through 9 February 2020, 472 laboratory confirmed cases including 70 deaths (case fatality ratio= 14.8%) have been reported in 26 out of 36 Nigerian states and the Federal Capital Territory....
The temperature wouldnt go down, nothing seemed to be working for it. The stooling persisted too. We had to used an underlay for her and passed a urinary catheter, Then the unexpected happened. A line of blood flowed out of a nostril. A nurse was around her at the time. The nurse cleaned the nose and waited to be sure it was blood. Few seconds later, the nostril bled again, this time it was more, the other nostril followed. She quickly called for a doctor who at first thought it was hemorrhage that was coming from the brain or somewhere else. He called for a neurologist who changed the line of management (fluids, drugs and all). ...
THE CHALLENGE: People sick with mystery fevers in the remote Thirthahalli Hospital in India often had to either wait weeks for test results or travel long distances to access more advanced labs. As a result, nearly none of the patients at the hospital received a confirmed diagnosis.
Schlie K, Maisa A, Lennartz F, Stroher U, Garten W, Strecker T. Characterization of Lassa virus glycoprotein oligomerization and influence of cholesterol on virus replication. J Virol. 84(2):983-92. Epub 2009 Nov 4. (2009). [PubMed - 19889753] ...
Several viruses in the Arenaviridae family infect humans and cause severe hemorrhagic fevers which lead to high case fatality rates. Due to their pathogenicity and geographic tropisms, these viruses remain very understudied. As a result, an effective vaccine or therapy is urgently needed. Here, we describe efforts to produce cross-reactive monoclonal antibodies that bind to both New and Old World arenaviruses. All of our MAbs seem to be nonneutralizing and nonprotective and target subunit 2 of the glycoprotein. Due to the lack of reagents such as recombinant glycoproteins and antibodies for rapid detection assays, our MAbs could be beneficial as analytic and diagnostic tools.
The federal health agency explains the EbolaResponse modeling tool in the latest Morbidity and Mortality Weekly Report (MMWR).. Some of the numbers produced by the EbolaResponse tool include:. If trends continue without scale-up of effective interventions, by September 30, 2014, Sierra Leone and Liberia will have a total of approximately 8,000 Ebola cases.. A potential underreporting correction factor of 2.5 also was calculated. Using this correction factor, the model estimates that approximately 21,000 total cases will have occurred in Liberia and Sierra Leone by September 30, 2014.. Extrapolating trends to January 20, 2015, without additional interventions or changes in community behavior (e.g., notable reductions in unsafe burial practices), the model also estimates that Liberia and Sierra Leone will have approximately 550,000 Ebola cases (1.4 million when corrected for underreporting).. The authors do point out five limitations to the findings:. First, extrapolating current trends in ...
Lassa Fever (Lassa Hemorrhagic Fever) - Pipeline Review, H1 2017 is a market research report available at US $2000 for a Single User PDF License from RnR Market Research Reports Library.
FREETOWN (AFP) - A woman in Sierra Leone has died from the Ebola virus, a health ministry official announced on Wednesday, the second person in the west African country to succumb to the haemorrhagic fever.. Read more at straitstimes.com.
Bethany Morse (Class of 1999) works at Kamakwie Wesleyan Hospital in Sierre Leone, Africa. Here is a recent update from Bethany:. Ebola in Sierra Leone. "There are currently NO cases of Ebola in Kamakiwe. Very few cases are in Bombaili district where the hospital resides and the cases seen in the district are near and around Makeni, which is a bigger town about 55 miles away from Kamakwie.. According to the Health and Sanatation website in Sierra Leone as of February 10th, there have been 8,152 confirmed cases of Ebola Virus Disease in Sierra Leone, with 2,985 of those resulting in death and 2,218 survivors. The confirmed cases have been in all districts and areas of Sierra Leone. The new confirmed cases have been decreasing. The numbers are as low as 3 confirmed cases in a day to as many as 12 confirmed cases in a day for the whole country for the last few weeks.. Thank you for praying for this outbreak of Ebola and we are thankful that the staff at the hospital have been and continue to be ...
Via MSF: The Race To Control Ebola in Sierra Leone. Excerpt: The Ebola outbreak currently sweeping through West Africa is reaching an unprecedented scale in terms of its geographical spread, the number of cases, and the number of victims. According...
Explore the mysteries of West Africa on this extensive journey from Ghana to Sierra Leone, taking in Kumasi, Grand Bassam, Korhog and Kabala along the way.
On July 15, the WHO reported a total of 964 cases including 603 deaths in Guinea, Sierra Leone, and Liberia. Guinea still has the greatest number of... ...
The Argentine FA on Thursday announced its financial numbers from the second half of 16 and the first half of 17, including a surplus of 99.8M Argentine pesos ($5.7M), according to CLARÍN. The AFA was able to erase a deficit that stood at more than 200M Argentine pesos after the...
The Kulp laboratory focuses on rational vaccine and therapeutic antibody design for a variety of priority infectious diseases (e.g. Lassa Virus, HIV, Influenza) and cancer targets.
The Argentine British Community Council, is a Non-profit Welfare organisation that brings the Community together to raise funds and care for those who are in need.
13 new suspected cases were reported from four states during the last week of July, namely: Plateau (5), Ondo (5) Bauchi (2), and Ogun (1), including two deaths.. Since the resurgence of the current Lassa fever outbreak in December 2016, 681 suspected cases including 112 deaths (overall case fatality rate 16.4%) have been reported.. Nigeria is one of several West African countries in which Lassa fever is endemic, with seasonal outbreaks occurring annually between December and June. In 2016, Nigeria reported 273 suspected cases and 149 deaths (case fatality rate 55%) from 23 states. In 2017, Benin, Burkina Faso, Sierra Leone, and Togo experienced outbreaks that have since been controlled.. The current outbreak of Lassa fever in Nigeria, however, is continuing beyond the normal season.. This persistent Lassa fever outbreak comes against the background of a protracted humanitarian crisis in the northern part of the country, as well as outbreaks of cholera and hepatitis E.. Visit myLABBox.com for ...
Toké on sea coast of Sierra Leone by Rev W H Maude. Return to W T Balmer". Distant view of village. William Maude served in Sierra Leone from 1867 to 1910, and in the Gold Coast district from 1915 to 1920.; Methodist Missionary work in West Africa had begun in 1811 with Cokes mission to Sierra Leone. A second station was opened on the River Gambia in 1821, and on the Gold Coast in 1834. Rev. Balmer served in the Sierra Leone and Gambia district from 1901 to 1909 whn he transferred to the Gold Coast briefly until 1911. He resumed his work in Sierra Leone from 1914 to 1921 ...
Three patients who received visceral-organ transplants from a single donor on the same day died of a febrile illness 4 to 6 weeks after transplantation. Culture, polymerase-chain-reaction (PCR) and serologic assays, and oligonucleotide microarray analysis for a wide range of infectious agents were not informative.,We evaluated RNA obtained from the liver and kidney transplant recipients. Unbiased high-throughput sequencing was used to identify microbial sequences not found by means of other methods. The specificity of sequences for a new candidate pathogen was confirmed by means of culture and by means of PCR, immunohistochemical, and serologic analyses.,High-throughput sequencing yielded 103,632 sequences, of which 14 represented an Old World arenavirus. Additional sequence analysis showed that this new arenavirus was related to lymphocytic choriomeningitis viruses. Specific PCR assays based on a unique sequence confirmed the presence of the virus in the kidneys, liver, blood, and cerebrospinal ...
FREETOWN, Sierra Leone - Shoppers in Sierra Leone rushed to stock up on food Thursday ahead of a three-day nationwide shutdown, during which the countrys 6 million people will be confined to their ho...
Ebola Virus Disease, Fever, Lassa Fever Symptom Checker: Possible causes include Marburg Virus Disease, Viral Hemorrhagic Fever, Crimean Hemorrhagic Fever. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.
The U.S. government will not renew funding for a major research project into Lassa fever, a decision that will, in turn, cut resources for a facility in Sierra Leone that is at the forefront of the current battle against the Ebola virus.
Arenaviruses are feared as agents that cause viral hemorrhagic fevers. We report the identification, isolation, and genetic characterization of 2 novel arenaviruses from Namaqua rock mice in Namibia. These findings extend knowledge of the distribution and diversity of arenaviruses in Africa.

Arenaviridae  | Viral Hemorrhagic Fevers (VHFs) | CDCArenaviridae | Viral Hemorrhagic Fevers (VHFs) | CDC

The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. ... The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. ... By the 1960s, several similar viruses had been discovered and they were classified into the new family Arenaviridae. Since ...
more infohttps://www.cdc.gov/vhf/virus-families/arenaviridae.html

Canary Database: Browse by Exposure: ArenaviridaeCanary Database: Browse by Exposure: Arenaviridae

Browse by Exposure: Arenaviridae (2 articles). % of records by year: 1965 2017 ...
more infohttp://canarydatabase.org/browse/exposure/3755

Canary Database: Browse by Outcome: Arenaviridae InfectionsCanary Database: Browse by Outcome: Arenaviridae Infections

Browse by Outcome: Arenaviridae Infections (2 articles). % of records by year: 1965 2017 ...
more infohttp://canarydatabase.org/browse/outcome/3756

Arenaviridae Infections | Profiles RNSArenaviridae Infections | Profiles RNS

"Arenaviridae Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Arenaviridae Infections" by people in this website by year, ... Below are the most recent publications written about "Arenaviridae Infections" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Arenaviridae Infections". ...
more infohttps://profiles.umassmed.edu/display/118243

Arboviruses, Arenaviridae, and Filoviridae - Merck Manuals Professional EditionArboviruses, Arenaviridae, and Filoviridae - Merck Manuals Professional Edition

Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
more infohttp://www.merckmanuals.com/professional/infectious-diseases/arboviruses,-arenaviridae,-and-filoviridae

Arenaviridae infections | definition of Arenaviridae infections by Medical dictionaryArenaviridae infections | definition of Arenaviridae infections by Medical dictionary

What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean? ... Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. ... See Arenaviridae. A·re·na·vi·rus. (ă-rēnă-vīrŭs) A genus in the family Arenaviridae that is associated with lymphocytic ... redirected from Arenaviridae infections). Also found in: Dictionary, Thesaurus. arenavirus. [ah-re´nah-vi″rus] any member of a ...
more infohttp://medical-dictionary.thefreedictionary.com/Arenaviridae+infections

Canary Database: Browse by Exposure: ArenaviridaeCanary Database: Browse by Exposure: Arenaviridae

Browse by Exposure: Arenaviridae (2 articles). % of records by year: 1965 2017 ...
more infohttp://podcast.canarydatabase.org/browse/exposure/3755

WHO | New virus from Arenaviridae family in South Africa and Zambia - UpdateWHO | New virus from Arenaviridae family in South Africa and Zambia - Update

New virus from Arenaviridae family in South Africa and Zambia - Update. 13 October 2008 - The results of tests conducted at the ... is a virus from the Arenaviridae family. ...
more infohttp://origin.who.int/entity/csr/don/2008_10_13/en/

Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018.  - PubMed - NCBITaxonomy of the family Arenaviridae and the order Bunyavirales: update 2018. - PubMed - NCBI

Taxonomy of the family Arenaviridae and the order Bunyavirales: update 2018.. Maes P1, Alkhovsky SV2, Bào Y3, Beer M4, Birkhead ... In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently ... This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=cdcpub&id=4279

CBRNE - Viral Hemorrhagic Fevers: Background, Pathophysiology, EpidemiologyCBRNE - Viral Hemorrhagic Fevers: Background, Pathophysiology, Epidemiology

Arenaviridae. Arenaviridae are spread to humans by rodent contact and include Lassa virus in Africa and several rare South ... Lassa virus is the most clinically significant of the Arenaviridae, accounting for serious morbidity and mortality in West ... Four viral families are known to cause VHFs in humans: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. General ...
more infohttps://emedicine.medscape.com/article/830594-overview

Cell Culture and Electron Microscopy for Identifying Viruses in Diseases of Unknown Cause - Volume 19, Number 6-June 2013 -...Cell Culture and Electron Microscopy for Identifying Viruses in Diseases of Unknown Cause - Volume 19, Number 6-June 2013 -...

Family Arenaviridae. Organ and tissue transplantation have become relatively common surgical procedures, and on rare occasions ... and identified by EM as belonging to the family Arenaviridae. IFA assay and PCR showed that the agent was lymphocytic ...
more infohttps://wwwnc.cdc.gov/eid/article/19/6/13-0173

Arenavirus | Article about arenavirus by The Free DictionaryArenavirus | Article about arenavirus by The Free Dictionary

Arenaviridae. (redirected from arenavirus). Also found in: Dictionary, Thesaurus, Medical, Wikipedia.. Related to arenavirus: ... Arenaviridae. [ə‚rēn·ə′vī·rə‚dē] (virology) A family of ribonucleic acid animal viruses consisting of a single genus, ...
more infohttp://encyclopedia2.thefreedictionary.com/arenavirus

Chikungunya - WikipediaChikungunya - Wikipedia

Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
more infohttps://en.wikipedia.org/wiki/Chikungunya_vaccine

Lassa virus - WikipediaLassa virus - Wikipedia

Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
more infohttps://en.wikipedia.org/wiki/Lassa_virus

Virology by Christian - IssuuVirology by Christian - Issuu

Arenaviridae. Lymphocytic choriomeningitis and Lassa fever viruses. Rhabdoviridae. Rabies virus. Filoviridae. Marburg and Ebola ...
more infohttps://issuu.com/christianmugabo/docs/virology

Whats in the Collection | Division of Vector-Borne Diseases | NCEZID | CDCWhat's in the Collection | Division of Vector-Borne Diseases | NCEZID | CDC

The ARC houses reference quantities of reagents and reference viruses that can be distributed to research and commercial laboratories. The collection also serves as an arbovirus repository for reference strains.
more infohttps://www.cdc.gov/ncezid/dvbd/specimensub/arc/whats-in-the-collection.html

ArboCat Virus: Ippy (IPPYV)ArboCat Virus: Ippy (IPPYV)

Arenaviridae Genus. Arenavirus Information From. J.P. Digoutte Address. Institut Pasteur B.P. 304 Cayenne Guyane Francaise ...
more infohttps://wwwn.cdc.gov/Arbocat/VirusDetails.aspx?ID=194

ArboCat Virus: Ippy (IPPYV)ArboCat Virus: Ippy (IPPYV)

Arenaviridae Genus. Arenavirus Information From. J.P. Digoutte Address. Institut Pasteur B.P. 304 Cayenne Guyane Francaise ...
more infohttps://wwwn.cdc.gov/Arbocat/VirusDetails.aspx?ID=194&SID=1

Virus | Encyclopedia.comVirus | Encyclopedia.com

Arenaviridae Lassa fever virus. primates. hemorrhagic fever. ds RNA. +/-. Reoviridae Rice dwarf virus. plants. stunting. ...
more infohttps://www.encyclopedia.com/plants-and-animals/microbes-algae-and-fungi/moneran-and-protistan/virus

Patent US20030152942 - Nucleic acid detection in pooled samples - Google PatentsPatent US20030152942 - Nucleic acid detection in pooled samples - Google Patents

Arenaviridae, Rhabdoviridae, Coronaviridae, Bunyaviridae, and Retroviridae. For example, it is intended that the present ...
more infohttp://www.google.com/patents/US20030152942?dq=6101531

Volume 65, Issue 2 | The American Journal of Tropical Medicine and HygieneVolume 65, Issue 2 | The American Journal of Tropical Medicine and Hygiene

Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae). C F Fulhorst, M L Milazzo, R ...
more infohttp://www.ajtmh.org/content/journals/14761645/65/2

Virus-Taxonomie - WikipediaVirus-Taxonomie - Wikipedia

Familie Arenaviridae. *Genus Hartmanivirus, mit Species Haartman-Institut-Schlangen-Virus. *Genus Mammarenavirus (früher ...
more infohttps://de.wikipedia.org/wiki/Virus-Taxonomie

Fenners Veterinary Virology by N. James Maclachlan BVSc,  MS,  PhD |, Paperback | Barnes & Noble®Fenner's Veterinary Virology by N. James Maclachlan BVSc, MS, PhD |, Paperback | Barnes & Noble®

Arenaviridae 24. Coronaviridae 25. Arteriviridae 26. Picornaviridae 27. Caliciviridae 28. Astroviridae 29. Togaviridae 30. ...
more infohttps://www.barnesandnoble.com/w/fenners-veterinary-virology-n-james-maclachlan/1122732102
  • By the 1960s, several similar viruses had been discovered and they were classified into the new family Arenaviridae . (cdc.gov)
  • The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. (cdc.gov)
  • This collaborative effort allows each laboratory to contribute their strengths in analytical techniques towards the identification, characterization, and validation of antibodies against the Filoviridae and Arenaviridae families. (vhfc.org)