A family of RNA viruses naturally infecting rodents and consisting of one genus (ARENAVIRUS) with two groups: Old World Arenaviruses (ARENAVIRUSES, OLD WORLD) and New World Arenaviruses (ARENAVIRUSES, NEW WORLD). Infection in rodents is persistent and silent. Vertical transmission is through milk-, saliva-, or urine-borne routes. Horizontal transmission to humans, monkeys, and other animals is important.
Virus diseases caused by the ARENAVIRIDAE.
One of two groups of viruses in the ARENAVIRUS genus and considered part of the New World complex. It includes JUNIN VIRUS; PICHINDE VIRUS; Amapari virus, and Machupo virus among others. They are the cause of human hemorrhagic fevers mostly in Central and South America.
The only genus in the family ARENAVIRIDAE. It contains two groups ARENAVIRUSES, OLD WORLD and ARENAVIRUSES, NEW WORLD, which are distinguished by antigenic relationships and geographic distribution.
Diseases caused by American hemorrhagic fever viruses (ARENAVIRUSES, NEW WORLD).
A group of viral diseases of diverse etiology but having many similar clinical characteristics; increased capillary permeability, leukopenia, and thrombocytopenia are common to all. Hemorrhagic fevers are characterized by sudden onset, fever, headache, generalized myalgia, backache, conjunctivitis, and severe prostration, followed by various hemorrhagic symptoms. Hemorrhagic fever with kidney involvement is HEMORRHAGIC FEVER WITH RENAL SYNDROME.
A species of ARENAVIRUS, part of the Old World Arenaviruses (ARENAVIRUSES, OLD WORLD), and the etiologic agent of LASSA FEVER. LASSA VIRUS is a common infective agent in humans in West Africa. Its natural host is the multimammate mouse Mastomys natalensis.
A species of ARENAVIRUS, part of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing Argentinian hemorrhagic fever. The disease is characterized by congestion, edema, generalized lymphadenopathy and hemorrhagic necrosis and is sometimes fatal.
A subfamily of the family MURIDAE comprised of 69 genera. New World mice and rats are included in this subfamily.
An acute febrile human disease caused by the LASSA VIRUS.
A species of ARENAVIRUS, one of the New World Arenaviruses (ARENAVIRUSES, NEW WORLD), causing a fatal infection in the cricetine rodent Oryzomys albigularis. Asymptomatic laboratory infection in humans has been reported.
Viral proteins found in either the NUCLEOCAPSID or the viral core (VIRAL CORE PROTEINS).
The relationships of groups of organisms as reflected by their genetic makeup.
A family of RNA viruses, of the order MONONEGAVIRALES, containing filamentous virions. Although they resemble RHABDOVIRIDAE in possessing helical nucleocapsids, Filoviridae differ in the length and degree of branching in their virions. There are two genera: EBOLAVIRUS and MARBURGVIRUS.
Arthropod-borne viruses. A non-taxonomic designation for viruses that can replicate in both vertebrate hosts and arthropod vectors. Included are some members of the following families: ARENAVIRIDAE; BUNYAVIRIDAE; REOVIRIDAE; TOGAVIRIDAE; and FLAVIVIRIDAE. (From Dictionary of Microbiology and Molecular Biology, 2nd ed)
Protective places of employment for disabled persons which provide training and employment on a temporary or permanent basis.
An RNA virus infection of rhesus, vervet, and squirrel monkeys transmissible to man.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A contagious disease caused by canine adenovirus (ADENOVIRUSES, CANINE) infecting the LIVER, the EYE, the KIDNEY, and other organs in dogs, other canids, and bears. Symptoms include FEVER; EDEMA; VOMITING; and DIARRHEA.
Diseases of the domestic dog (Canis familiaris). This term does not include diseases of wild dogs, WOLVES; FOXES; and other Canidae for which the heading CARNIVORA is used.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.
A severe, often fatal disease in humans caused by the Crimean-Congo hemorrhagic fever virus (HEMORRHAGIC FEVER VIRUS, CRIMEAN-CONGO).
A species of NAIROVIRUS of the family BUNYAVIRIDAE. It is primarily transmitted by ticks and causes a severe, often fatal disease in humans.
A highly fatal, acute hemorrhagic fever, clinically very similar to MARBURG VIRUS DISEASE, caused by EBOLAVIRUS, first occurring in the Sudan and adjacent northwestern (what was then) Zaire.
An acute febrile disease occurring predominately in Asia. It is characterized by fever, prostration, vomiting, hemorrhagic phenonema, shock, and renal failure. It is caused by any one of several closely related species of the genus Hantavirus. The most severe form is caused by HANTAAN VIRUS whose natural host is the rodent Apodemus agrarius. Milder forms are caused by SEOUL VIRUS and transmitted by the rodents Rattus rattus and R. norvegicus, and the PUUMALA VIRUS with transmission by Clethrionomys galreolus.
Events that overwhelm the resources of local HOSPITALS and health care providers. They are likely to impose a sustained demand for HEALTH SERVICES rather than the short, intense peak customary with smaller scale disasters.
A species of ALPHAVIRUS causing an acute dengue-like fever.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Virus diseases caused by members of the ALPHAVIRUS genus of the family TOGAVIRIDAE.
The islands of the Pacific Ocean divided into MICRONESIA; MELANESIA; and POLYNESIA (including NEW ZEALAND). The collective name Oceania includes the aforenamed islands, adding AUSTRALIA; NEW ZEALAND; and the Malay Archipelago (INDONESIA). (Webster's New Geographical Dictionary, 1988, p910, 880)
Sudden increase in the incidence of a disease. The concept includes EPIDEMICS and PANDEMICS.
A body of water covering approximately one-fifth of the total ocean area of the earth, extending amidst Africa in the west, Australia in the east, Asia in the north, and Antarctica in the south. Including the Red Sea and the Persian Gulf, it constitutes the third largest ocean after the ATLANTIC OCEAN and the PACIFIC OCEAN. (New Encyclopaedia Britannica Micropaedia, 15th ed, 1990, p289)
Exclusive legal rights or privileges applied to inventions, plants, etc.
High molecular weight polymers containing a mixture of purine and pyrimidine nucleotides chained together by ribose or deoxyribose linkages.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
The misinterpretation of a real external, sensory experience.
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.
The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.
International collective of humanitarian organizations led by volunteers and guided by its Congressional Charter and the Fundamental Principles of the International Red Cross Movement, to provide relief to victims of disaster and help people prevent, prepare for, and respond to emergencies.
The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.

Experimental infection of the cane mouse Zygodontomys brevicauda (family Muridae) with guanarito virus (Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. (1/73)

Chronic infections in specific rodents appear to be crucial to the long-term persistence of arenaviruses in nature. The cane mouse, Zygodontomys brevicauda, is a natural host of Guanarito virus (family Arenaviridae), the etiologic agent of Venezuelan hemorrhagic fever. The purpose of this study was to elucidate the natural history of Guanarito virus infection in Z. brevicauda. Thirty-nine laboratory-reared cane mice each were inoculated subcutaneously with 3.0 log10 plaque-forming units of the Guanarito virus prototype strain INH-95551. No lethality was associated with infection in any animal, regardless of age at inoculation. The 13 newborn, 14 weanling, and 8 of the 12 adult animals developed chronic viremic infections characterized by persistent shedding of infectious virus in oropharyngeal secretions and urine. These findings indicate that Guanarito virus infection in Z. brevicauda can be chronic and thus support the concept that this rodent species is the natural reservoir of Guanarito virus.  (+info)

Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-alpha gene expression. (2/73)

Cells of the mononuclear and endothelial lineages are targets for viruses which cause hemorrhagic fevers (HF) such as the filoviruses Marburg and Ebola, and the arenaviruses Lassa and Junin. A recent model of Marburg HF pathogenesis proposes that virus directly causes endothelial cell damage and macrophage release of TNF-alpha which increases the permeability of endothelial monolayers [Feldmann et al. , 1996]. We show that Lassa virus replicates in human monocytes/macrophages and endothelial cells without damaging them. Human endothelial cells (HUVEC) are highly susceptible to infection by both Lassa and Mopeia (a non-pathogenic Lassa-related arenavirus). Whereas monocytes must differentiate into macrophages before supporting even low level production of these viruses, the virus yields in the culture medium of infected HUVEC cells reach more than 7 log10 PFU/ml without cellular damage. In contrast to filovirus, Lassa virus replication in monocytes/macrophages fails to stimulate TNF-alpha gene expression and even down-regulates LPS-stimulated TNF-alpha mRNA synthesis. The expression of IL-8, a prototypic proinflammatory CXC chemokine, was also suppressed in Lassa virus infected monocytes/macrophages and HUVEC on both the protein and mRNA levels. This contrasts with Mopeia virus infection of HUVEC in which neither IL-8 mRNA nor protein are reduced. The cumulative down-regulation of TNF-alpha and IL-8 expression could explain the absence of inflammatory and effective immune responses in severe cases of Lassa HF.  (+info)

Genetic diversity among Lassa virus strains. (3/73)

The arenavirus Lassa virus causes Lassa fever, a viral hemorrhagic fever that is endemic in the countries of Nigeria, Sierra Leone, Liberia, and Guinea and perhaps elsewhere in West Africa. To determine the degree of genetic diversity among Lassa virus strains, partial nucleoprotein (NP) gene sequences were obtained from 54 strains and analyzed. Phylogenetic analyses showed that Lassa viruses comprise four lineages, three of which are found in Nigeria and the fourth in Guinea, Liberia, and Sierra Leone. Overall strain variation in the partial NP gene sequence was found to be as high as 27% at the nucleotide level and 15% at the amino acid level. Genetic distance among Lassa strains was found to correlate with geographic distance rather than time, and no evidence of a "molecular clock" was found. A method for amplifying and cloning full-length arenavirus S RNAs was developed and used to obtain the complete NP and glycoprotein gene (GP1 and GP2) sequences for two representative Nigerian strains of Lassa virus. Comparison of full-length gene sequences for four Lassa virus strains representing the four lineages showed that the NP gene (up to 23.8% nucleotide difference and 12.0% amino acid difference) is more variable than the glycoprotein genes. Although the evolutionary order of descent within Lassa virus strains was not completely resolved, the phylogenetic analyses of full-length NP, GP1, and GP2 gene sequences suggested that Nigerian strains of Lassa virus were ancestral to strains from Guinea, Liberia, and Sierra Leone. Compared to the New World arenaviruses, Lassa and the other Old World arenaviruses have either undergone a shorter period of diverisification or are evolving at a slower rate. This study represents the first large-scale examination of Lassa virus genetic variation.  (+info)

Extreme genetic diversity among Pirital virus (Arenaviridae) isolates from western Venezuela. (4/73)

Pirital-like virus isolates from rodents collected in a variety of habitats within a six-state area of central Venezuela were analyzed genetically by amplifying a portion of the nucleocapsid protein gene using RT-PCR. Comparisons of the sequences from 30 selected Pirital-like virus isolates demonstrated up to 26% divergence in nucleotide sequences and up to 16% divergence in deduced amino acid sequences. Within the Pirital monophyletic group, 14 distinct lineages or genotypes, differing by at least 6% in nucleotide sequences, were identified. Although sample sizes were small for some lineages, many of the different genotypes were sampled in only one region or locality, suggesting allopatric divergence. Complement fixation tests with representatives of the most divergent Pirital virus lineages failed to delineate multiple species or subtypes within the Pirital clade. These results indicate that the previously proposed 12% nucleocapsid protein amino acid sequence divergence cutoff value for delineating arenavirus species is not appropriate for the entire family. When individual clones were examined from PCR amplicons, a mean of 0.17% sequence diversity vs the consensus sequences was detected, suggesting diverse quasispecies populations within infected rodent hosts. Possible explanations for the extreme genetic diversity within and among Pirital virus populations in infected rodents are discussed.  (+info)

Generation of "natural killer cell-escape" variants of Pichinde virus during acute and persistent infections. (5/73)

Pichinde virus (PV) strain AN 3739 was determined to be sensitive to natural killer (NK) cells in vivo by enhanced replication in NK-cell-depleted mice. An NK-sensitive subclone (PV-NKs1) was serially passed in mice whose NK cells had previously been activated by an interferon inducer, and two plaque isolates were shown to be resistant to NK cells but not to interferon. Inoculation of severe-combined-immunodeficient mice with PV-NKs1 led to a persistent infection resulting in an NK-resistant viral population. This is the first demonstration of the isolation of viral "NK-escape" variants, as defined by the ability of the virus to replicate in vivo.  (+info)

Posttranslational modification of alpha-dystroglycan, the cellular receptor for arenaviruses, by the glycosyltransferase LARGE is critical for virus binding. (6/73)

The receptor for lymphocytic choriomeningitis virus (LCMV), the human pathogenic Lassa fever virus (LFV), and clade C New World arenaviruses is alpha-dystroglycan (alpha-DG), a cell surface receptor for proteins of the extracellular matrix (ECM). Specific posttranslational modification of alpha-DG by the glycosyltransferase LARGE is critical for its function as an ECM receptor. In the present study, we show that LARGE-dependent modification is also crucial for alpha-DG's function as a cellular receptor for arenaviruses. Virus binding involves the mucin-type domain of alpha-DG and depends on modification by LARGE. A crucial role of the LARGE-dependent glycosylation of alpha-DG for virus binding is found for several isolates of LCMV, LFV, and the arenaviruses Mobala and Oliveros. Since the posttranslational modification by LARGE is crucial for alpha-DG recognition by both arenaviruses and the host-derived ligand laminin, it also influences competition between virus and laminin for alpha-DG. Hence, LARGE-dependent glycosylation of alpha-DG has important implications for the virus-host cell interaction and the pathogenesis of LFV in humans.  (+info)

Molecular organization of Junin virus S RNA: complete nucleotide sequence, relationship with other members of the Arenaviridae and unusual secondary structures. (7/73)

In this study, overlapping cDNA clones covering the entire S RNA molecule of Junin virus, an arenavirus that causes Argentine haemorrhagic fever, were generated. The complete sequence of this 3400 nucleotide RNA was determined using the dideoxynucleotide chain termination method. The nucleocapsid protein (N) and the glycoprotein precursor (GPC) genes were identified as two non-overlapping open reading frames of opposite polarity, encoding primary translation products of 564 and 481 amino acids, respectively. Intracellular processing of the latter yields the glycoproteins found in the viral envelope. Comparison of the Junin virus N protein with the homologous proteins of other arenaviruses indicated that amino acid sequences are conserved, the identity ranging from 46 to 76%. The N-terminal half of GPC exhibits an even higher degree of conservation (54 to 82%), whereas the C-terminal half is less conserved (21 to 50%). In all comparisons the highest level of amino acid sequence identity was seen when Junin virus and Tacaribe virus sequences were aligned. The nucleotide sequence at the 5' end of Junin virus S RNA is not identical to that determined of the other sequenced arenaviruses. However, it is complementary to the 3'-terminal sequences and may form a very stable panhandle structure (delta G-242.7 kJ/mol) involving the complete non-coding regions upstream from both the N and GPC genes. In addition, a distinct secondary structure was identified in the intergenic region, downstream from the coding sequences; Junin virus S RNA shows a potential secondary structure consisting of two hairpin loops (delta G -163.2 and -239.3 kJ/mol) instead of the single hairpin loop that is usually found in other arenaviruses. The analysis of the arenavirus S RNA nucleotide sequences and their encoded products is discussed in relation to structure and function.  (+info)

Receptor use by pathogenic arenaviruses. (8/73)

The arenavirus family contains several important human pathogens including Lassa fever virus (LASV), lymphocytic choriomeningitis virus (LCMV) and the New World clade B viruses Junin (JUNV) and Machupo (MACV). Previously, alpha-dystroglycan (alpha-DG) was identified as a receptor recognized by LASV and certain strains of LCMV. However, other studies have suggested that alpha-DG is probably not used by the clade B viruses, and the receptor(s) for these pathogens is currently unknown. Using pseudotyped retroviral vectors displaying arenavirus glycoproteins (GPs), we are able to explore the role played by the GP in viral entry in the absence of other viral proteins. By examining the ability of the vectors to transduce DG knockout murine embryonic stem (ES) cells, we have confirmed that LASV has an absolute requirement for alpha-DG in these cells. However, the LCMV GP can still direct substantial entry into murine ES cells in the absence of alpha-DG, even when the GP from the clone 13 variant is used that has previously been reported to be highly dependent on alpha-DG for entry. We also found that neither LASV or LCMV pseudotyped vectors were able to transduce human or murine lymphocytes, presumably due to the glycosylation state of alpha-DG in these cells. In contrast, the JUNV and MACV GPs displayed broad tropism on human, murine and avian cell types, including lymphocytes, and showed no requirement for alpha-DG in murine ES cells. These findings highlight the importance of molecules other than alpha-DG for arenavirus entry. An alternate receptor is present on murine ES cells that can be used by LCMV but not by LASV, and which is not available on human or murine lymphocytes, while a distinct and widely expressed receptor(s) is used by the clade B viruses.  (+info)

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Semantic Scholar extracted view of Ribonucleoprotein complexes associated with virions of Pichinde virus and Pichinde virus-infected cells by P. R. G. Young et al.
Pichinde virus (PIC) is a reticuloendothelial arenavirus of the New World tropics. A guinea pig passage-adapted strain of this virus (adPIC) is uniformly lethal for inbred guinea pigs, while the related, prototype strain (PIC3739) has attenuated virulence. The abilities of adPIC and PIC3739 to induce tumor necrosis factor (TNF) in vivo and in cultured macrophages were compared. Infection with adPIC, but not PIC3739, was associated with detectable serum TNF that peaked in week 2 of infection. Tumor necrosis factor was found in the spleens of adPIC- and PIC3739-infected animals in week 1 of infection ; TNFα mRNA levels in spleens and livers of adPIC infected animals increased and remained high throughout infection, whereas PIC3739-infected organs showed down regulation of TNFα mRNA late in infection. Peritoneal macrophages explanted from adPIC-infected animals showed enhanced lipopolysaccharide-inducible TNF production. Altered regulation of TNF production may play a role in the pathogenesis of guinea
The established animal model for Lassa fever is based on the new world arenavirus Pichinde (PIC). Natural isolates of PIC virus are attenuated in guinea pigs, but serial guinea pig passage renders them extremely virulent in that host. We have compared the nucleotide sequences of the small RNA segments of two attenuated, low-passage variants of the PIC virus Munchique strain (CoAn 4763) and two virulent, high-passage derivatives. Missense mutations in the glycoprotein precursor (GPC) gene at codons GPC-119, GPC-140, and GPC-164 and the nucleoprotein gene (NP) codons NP-35 and NP-374 were most closely associated with virulence. Codon GPC-140 is predicted to represent a region of peak hydrophilicity of the glycoprotein 1 (GP1); it is conceivable that mutations at this site could influence virulence by altering B cell epitopes or virus attachment protein conformation.
We have investigated the double-layered carbon nano-onions (CNOs) C₂₀@C₆₀, C₂₀@C₈₀, C₆₀@C₁₈₀, C₆₀@C₂₄₀, C₈₀@C₂₄₀, and C₂₄₀@C₅₄₀ as well as their triple-layered analogues C₆₀@C₂₄₀@C₅₄₀ and C₈₀@C₂₄₀@C₅₄₀ with high-level electronic structure calculations. We were able to show that earlier work, which showed the free rotation of the inner fullerene in a CNO, does not extend to multilayered CNOs. We sh ...
Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean?
Two days after infecting groups of guinea pigs with a lethal dose of Lassa virus, the scientists treated the rodents daily for two weeks with either ribavirin, low doses of favipiravir, or high doses of favipiravir. They also evaluated the effect of high-dose favipiravir in the rodents that began treatment five, seven or nine days after infection. All of the animals that received high-dose favipiravir were completely protected from lethal infection; animals treated seven or nine days after infection had begun showing signs of disease, but their conditions quickly improved when treatment began. Those animals in the low-dose favipiravir group showed mild to moderate signs of disease, but those symptoms resolved after about one week of treatment. The animals treated with ribavirin appeared normal during the treatment phase but developed severe disease shortly after treatment ended. ...
Lassa fever is an acute viral haemorrhagic illness of 1-4 weeks duration that occurs in West Africa. Lassa Fever, Lassa Fever Symptoms, Lassa Fever Prevention
Lassa fever is an acute viral haemorrhagic illness of 1-4 weeks duration that occurs in West Africa. Lassa Fever, Lassa Fever Symptoms, Lassa Fever Prevention
Lassa Virus Essay, Research Paper The Lassa virus is a vulgar virus with a high mortality rate and an expensive cure. Lassa was strange to me because I have never heard of the virus before. As I was reading in my research, I began to realize the risk the virus has on people.
Virulent and highly transmissible member of the Arenaviridae whose normal host is a rodent (Mastomys natalensis ) ; first recorded from Nigeria
Researchers have uncovered structural and functional details of a key Lassa virus protein; this new information may aid the development of vaccines.
Pull over to the side of the road if you need to make a call or if you are receiving an incoming call. This will ensure that you are safe and that the other drivers on the road are safe too
Looking for Guanarito virus? Find out information about Guanarito virus. parasite with a noncellular structure composed mainly of nucleic acid nucleic acid, any of a group of organic substances found in the chromosomes of living... Explanation of Guanarito virus
According to a release issued in Monrovia, from January 1, 2019 to December 31, 2019, NPHIL, through the National Reference Laboratory, recorded 50 confirmed cases of Lassa fever. Of the 50 cases, 18 deaths were recorded, a Case Fatality Rate (CFR) of 36%. This 2019 CFR is a significant improvement compared to the 2018 CFR of 66%.. In view of the aforementioned recent Lassa fever cases, and the fact that NPHIL has responded to an average of one Lassa fever case per week in recent months, NPHIL, in collaboration with the Ministry of Health, has deemed it expedient to announce that Liberia has had a continuous Lassa fever outbreak.. The release also disclosed that although Lassa fever is not new to Liberia, it is a potentially deadly viral disease that requires urgent attention. The disease is spread by rodents or rats and through close contact with affected persons. Lassa fever is not as infectious as Ebola and rarely spread from persons to persons. However, health workers, communities, and the ...
To determine whether Lassa virus was circulating in southern Mali, we tested samples from small mammals from 3 villages, including Soromba, where in 2009 a British citizen probably contracted a lethal Lassa virus infection. We report the isolation and genetic characterization of Lassa virus from an area previously unknown for Lassa fever.
Argentine hemorrhagic fever (AHF) was recognized as a new clinical entity from the richest farming region of Argentina in the 1950s (Arribalzaga 1955). The etiologic agent of this disease, Junin virus
Los síndromes infecciosos asociados a arenavirus en América del sur son cuatro: síndrome febril de origen viral; fiebres hemorrágicas con o sin compromiso neurológico; meningitis asépticas y meningo-encefalitis. Entre los Arenavirus del nuevo mundo, está el complejo Tacaribe donde se encuentran los virus: Junín (Argentina), Guanarito (Venezuela), Machupo (Bolivia) y Sabiá (Brasil), que se caracterizan por causar fiebres hemorrágicas. En Colombia fue aislado el arenavirus Pichindé en 1965, del roedor Oryzomys albigularis, en el valle de Pichindé (Valle del Cauca). Este arenavirus produce una infección persistente en su hospedero y no es patógeno para el hombre. Hay evidencias de la circulación del virus Guanarito en roedores de Córdoba, pero no existen casos diagnosticados en humanos; en Sincelejo (Colombia) se detectó el genoma del virus coriomeningitis linfocítica en cerebros de roedores Mus musculus. El diagnóstico se basa en el conocimiento de la epidemiología local y la sospecha
The study set to assess the knowledge and attitude to Lassa fever among primary care providers. Structured questionnaires were administered to consenting primary care workers in Private and Primary health centres in Ekpoma. Data analysis was carried out using SPSS version 15. One hundred and thirty five (135) health workers participated in the study. One hundred and thirty one (97.0%) respondents had previously heard of Lassa fever. Overall knowledge of Lassa fever was poor for 51 (38.9%), and fair for 54 (41.2%) and good for 260 (19.8%). Hand gloves were stated as the most useful personal protective gear when dealing with a patient with Lassa fever. Fifty six (42.7 %) felt their level of knowledge was sufficient for them to safely and effectively handle a patient, 126 (96.4%) expressed their desire to know more about Lassa fever. The primary care health worker in a rural area is the one most likely to be the first point of call for persons seeking orthodox medicine. It is therefore essential ...
Health & Fitness · Lassa fever virus is an animal-borne or zoonotic, acute viral illness which was discovered in the year 1969. This virus killed two missionary nurses in Nigeria in 1969...
The first case of the current outbreak was reported from Bauchi in November, 2015. This was followed by cases reported by Kano State, and subsequently the other states mentioned above. Lassa fever is an acute febrile illness, with bleeding and death in severe cases, caused by the Lassa fever virus with an incubation period of 6-21 days. Lassa fever was first detected in Nigeria in 1969.The number of recorded cases peaked in 2012 when 1,723 cases with 112 fatalities were recorded. It has continued to decline since then ...
Arenaviruses are enveloped, bipartite negative single-stranded RNA viruses that can cause a wide spectrum of disease in humans and experimental animals including hemorrhagic fever. The majority of these viruses are rodent-borne and the arenavirus family can be divided into two groups: the Lassa-Lymphocytic choriomeningitis serocomplex and the Tacaribe serocomplex. Arenavirus-induced disease may include characteristic symptoms ranging from fever, malaise, body aches, petechiae, dehydration, hemorrhage, organ failure, shock, and in severe cases death. Currently, there are few prophylactic and therapeutic treatments available for arenavirus-induced symptoms. Supportive care and ribavirin remain the predominant strategies for treating most of the arenavirus-induced diseases. Therefore, efficacy testing of novel therapeutic and prophylactic strategies in relevant animal models is necessary. Because of the potential for person-to-person spread, the ability to cause lethal or debilitating disease in humans,
Junin virus buds at CD9-enriched sites. JUNV-A647 viral particles stained with either a CD9 antibody conjugated to PE (a) or Cholera Toxin B (CTB) conjugated to
BACKGROUND INFORMATION ABOUT CONVALESCENT PLASMA: Passive immunity has proven effective for cytomegalovirus (CMV), hepatitis B virus, rabies, tetanus, varicella, certain SARS variants, Argentine Hemorrhagic Fever, and various other illnesses. Convalescent plasma has been cited as a potential therapy for viral infection dating back to the 1918 Spanish influenza A (H1N1) pandemic. Since that time, convalescent plasma as passive immune therapy has been evaluated in the treatment of: Ebola, SARS coronavirus (SARS-CoV), 2009 pandemic influenza A (H1N1), Argentine Hemorrhagic Fever, CMV, Parvovirus B19, and others. Furthermore, a February 2020 WHO report states The cellular infectivity of the isolated viruses could be completely neutralized by the sera collected from convalescent patients. [Source: https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf ] ABOUT CERUS Cerus Corporation is dedicated solely to safeguarding the worlds blood supply and ...
January 7, 2016 - Lassa Fever Outbreak Kills 35 In Ibadan Oyo , Niger, Taraba, Kano, Rivers & Edo States, 76 Quarantined At least 35 people have
Funmi,. Its good to be loyal. But when lives are being lost, let us call a spade a spade. MOH has been deafeningly silent on Lassa Fever. Not the same as when Ebola was the issue. HEre is why a lot of noise is good around Lassa fever. First, it will keep the masses on the alert. Second, it will ensure dissemination of public health messages about symptoms, what to do when you have symptoms. Three, it will alert the medical community from doctors to nurses. Four, it will foster discussions at state and local levels about allocation of resources specially for this issue. Now, what is the role of the feds? The role of the federal government led by PMB and his minister for health is to initiate this communication action plan, define a coordinating strategy for collecting surveillance data (a key element in owning and subduing epidemics), set up a coordination strategy that is known to health officials, other officials and the general public, ascertain where resources are needed, and mobilize ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
Key facts Lassa fever is an acute viral hemorrhagic illness, with a duration of 1-4 weeks duration that occurs in West Africa. The Lassa virus is transmitted to humans via contact with food or household items contaminated with rodent urine or faeces. Person-to-person infections and laboratory transmission can also
Kayode Idowu, Maiduguri Twenty persons have been quarantined in Borno State as Lassa fever spread to the state. Briefing newsmen on Wednesday in ...
The death toll from a Lassa fever outbreak in northern Nigeria has risen to 41, the Nigeria Center for Disease Control announced this week.
Ebola also claimed victims in Nigeria...and the government there won plaudits for quickly containing the outbreak. Now though another virus is spreadi...
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This is the first case of Lassa fever to be imported from Mali to the United Kingdom. This paper discusses the investigations, the virological analysis, the surveillance and management of contacts undertaken following a case of Lassa fever.
Lassa virus belongs to the Arenaviridae family and causes Lassa fever, also known as Lassa haemorrhagic fever (LHF). It is a haemorrhagic illness that occurs between one and three weeks after infection.. Lassa fever is a zoonotic disease, meaning it passes from animals to humans. The natural host of Lassa virus is the rodent Mastomys natalensis, otherwise known as the Natal multimammate mouse or rat.. The virus is spread when a person comes into contact with items contaminated with the rodents urine or faeces - for example, by handling objects, eating or through open wounds. It can also be inhaled.. Lassa virus can pass from person to person via bodily fluids, and can spread in healthcare settings if suitable precautions are not taken.. ...
January 26, 2016 - Lassa Fever Virus Disease Hits Abeokuta Ogun State, 19 FUNAAB Students Isolated 19 suspected primary carriers of Lassa fever in Ogun
TY - JOUR. T1 - Attenuated replication of lassa virus vaccine candidate ML29 in STAT-1 -/- mice AU - Johnson, Dylan M.. AU - Jokinen, Jenny D.. AU - Lukashevich, Igor S.. PY - 2019/3/1. Y1 - 2019/3/1. N2 - Lassa virus (LASV), a highly prevalent mammalian arenavirus endemic in West Africa, can cause Lassa fever (LF), which is responsible for thousands of deaths annually. LASV is transmitted to humans from naturally infected rodents. At present, there is not an effective vaccine nor treatment. The genetic diversity of LASV is the greatest challenge for vaccine development. The reassortant ML29 carrying the L segment from the nonpathogenic Mopeia virus (MOPV) and the S segment from LASV is a vaccine candidate under current development. ML29 demonstrated complete protection in validated animal models against a Nigerian strain from clade II, which was responsible for the worst outbreak on record in 2018. This study demonstrated that ML29 was more attenuated than MOPV in STAT1 -/- mice, a small animal ...
Lassa fever has killed 100,000 Nigerians - Expert. Prof. Dennis Agbonlahor, a member of the National Committee on the Control of Lassa fever, says the virus had killed more than 100,000 Nigerians since the discovery of the virus in the country, calling for more funding and political will to combat the scourge.. Agbonlahor said this while presenting a paper titled Combating Lassa fever: A National Health Challenge, organised by the University of Benin on Friday in Benin.. The expert therefore, commended the Federal Government for creating moreawareness about the disease calling for sustenance of the awareness initiative.. Also, he applauded the trials of newly developed Lassa virus vaccine in the country.. He said that the vaccine developed by a combined team from the U.S. Army Medical Research Institute for Infectious Diseases and the Public Health Agencies of Canada was a promising vaccine for controlling Lassa fever.. According to him, this live and harmless vaccine, which is wrapped in a ...
Neighbor-joining phylogenetic tree of Machupo virus derived from the glycoprotein precursor gene sequence. The neighbor-joining and maximum likelihood analyses
Explanation:. Lassa fever or Lassa hemorrhagic fever (LHF) is caused by Lassa virus. This disease is mainly prevalent in West Africa countries such as Nigeria, Liberia, Sierra Leone, Guinea, and Ghana. It results in 5000 deaths every year. Its a zoonotic disease transmits to human from a species of mouse. ...
This resource examines the sites of interactions between humans and the multimammate mouse, Mastomys natalensis. It presents findings such as new arenaviruses in other African rodents and in snakes, that argue preferably toward the host-switching concept. The recent emergence in Sierra Leone, the absence of virus positive Mastomys between the two endemic zones and poor virus diversity in the Mano River area also point in the direction of a unique import of Lassa virus from Nigeria to Sierra Leone during the 19th century. This resource also discusses the hypothesis of human displacements through the Atlantic slave trade and its abolition in 1807.. Read more ...
Two persons, including a 36-year-old pregnant woman, have died at the Lagos University Teaching Hospital, LUTH, Idi-Araba, after being treated for Lassa fever.. Also, not less than 100 different hospital workers, who were exposed to the index case, including a resident doctor from the Department of Anatomic and Molecular Pathology are currently under close observation in LUTH, THISDAY investigations have shown.. The resident doctor was said to have taken part in the autopsy of the late pregnant woman. He is currently at the surveillance unit of the hospital, where he is being treated.. The Chief Medical Director, LUTH, Prof. Chris Bode, told THISDAY that the two patients died within a few days of admission as they presented late to the hospital in spite of efforts of the health workers to save their lives, adding that the late pregnant womans post-mortem examination was conducted before her Lassa fever status was eventually suspected and confirmed.. The Centre for Disease Control (CDC) in ...
FBI will investigate the Texas biolab where a deadly virus went missing, according to the Centers for Disease Control and Prevention.
According to him, we demonstrated and emphasised to the general public that all it takes to see a doctor is simply the decision to do so; we also organised a press conference on Lassa fever outbreak and in liaison with other stakeholders, ensured that Enugu State was Lassa free, while our committee on hemorrhagic fever worked closely with the state ministry of health and management of all hospitals to fight Lassa.. He also disclosed that the association was actively involved in the fight against quacks and impersonation of the medical profession by disgruntled elements, adding that the leadership during the period launched into the radio and TV waves, jingles on the best way to assess quality health care services and the need to make a qualified medical doctor the point of call on health issues.. He recalled that during their courtesy visit to the Enugu State Governor, Hon. Ifeanyi Ugwuanyi, at the Government House, the NMA handed a framework document on the road map towards effective health ...
VHFC partner, Corgenix Medical Corporation, has developed the first commercialized diagnostic test that enables rapid diagnosis of Lassa viral hemorrhagic fever.. This 15-minute test has the potential to completely change stye way Lassa fever is detected and treated, said Douglas Simpson, Corgenix President.. Read the full press release on the Corgenix website. ...
Nucleic Acid: Plasmid for expression of the LCMV S-segment with heterologous arenavirus GP - Machupo (Expression plasmid, Diagnostic reagent, Derived product, Nucleic Acid, Cloned nucleic acid)
The Ogun State Commissioner for Health, Babatunde Ipaye has confirmed the outbreak of Lassa fever saying a 20-year-old patient tested positive for the virus and has been moved to one of the isolation centres set up by the state government ...
Samuel Awoyinfa, Tobi Aworinde, Bukola Bakare and Joy Marcus There is palpable fear in Ogun State over a suspected case of Lassa fever in the stat...
Dr. Idris is a famous health specialist, There were some controversies came up on their hospital but he refused all the controversies and clearly stated that lassa fever patients will get recovered soon by the treatment of his hospital.. ReplyDelete ...
A team of British experts is being sent to Nigeria to help the country contain the biggest outbreak of Lassa fever in recent years.
Adamawa State has recorded its first case of death from Lassa Fever. The victim, a personnel of the Nigerian Security and Civil Defense Corps (NSCDC) identified as Gabriel Ambe, serving in Gembu, Taraba, is said to have died on Thursday at the Federal Medical Centre in Yola.
Ebola virus disease (EVD) is a dreaded viral disease and the first case of the virus was recorded in 1976 in Zaire which was where it g ...
For 2016, EU/EEA countries reported three cases of Lassa fever. Germany reported two cases, and Sweden reported one case. These were the first Lassa fever cases reported by EU/EEA countries since 2009 when two cases were reported by the United Kingdom. ...
Free, official coding info for 2021 ICD-10-CM A96.2 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
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Viruses from the Arenaviridae family, to which Lujo virus belongs, almost always have a rodent reservoir, with one virus in the ... Lujo is a bisegmented RNA virus-a member of the family Arenaviridae-and a known cause of viral hemorrhagic fever (VHF) in ... "Arenaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 18 December 2018. "Lujo Hemorrhagic Fever (LUHF ...
Viral Zone "Arenaviridae" Zhou, X; Ramachaundran, S; Mann, M; Popkin, DL (2012). "Role of Lymphocytic Choriomeningitis virus( ... Viral Zone "Arenaviridae". Hill, A. Edward (1948). "Benign lymphocytic meningitis". Caribbean Medical Journal. XI (1): 34-7. ... Its causative agent is lymphocytic choriomeningitis mammarenavirus (LCMV), a member of the family Arenaviridae. The name was ... Virus Pathogen Database and Analysis Resource (ViPR): Arenaviridae Palacios, Druce, Du, Tran, Birch, Briese, Conlan, Quan, Hui ...
... is a species of virus in the family Arenaviridae. The rodent species Sooretamys angouya is a host of this ...
In Arenaviridae and Bunyavirales, cap-snatching takes place in the cytoplasm. Cap-snatching occurs in three general steps: 1) ... Baloxavir marboxil (Xofluza) is effective against both influenza A and B. The family Arenaviridae and order Bunyavirales are ... The nucleoprotein structure in Lassa virus (Arenaviridae) contains a second nuclease. Researchers propose that it is involved ... Examples of viruses that engage in cap-snatching include influenza viruses (Orthomyxoviridae), Lassa virus (Arenaviridae), ...
in the family Arenaviridae change the name of genus Arenavirus to Mammarenavirus and convert the names of its constituent ... 2 July 2014). "Rename one (1) genus and twenty-five (25) species in the family Arenaviridae" (PDF). International Committee on ...
BHF was first identified in 1963 as an ambisense RNA virus of the Arenaviridae family, by a research group led by Karl Johnson ...
Lassa virus (Arenaviridae) Lymphocytic choriomeningitis virus (Arenaviridae) Hantavirus (Hantaviridae) Marburg virus ( ...
Alphasatellitidae Alphatetraviridae Alvernaviridae Amalgaviridae Amnoonviridae Ampullaviridae Anelloviridae Arenaviridae ...
Arenaviridae (Lassa fever, South American hemorrhagic fevers) and SARS CoV. He runs an active program of human and animal ...
Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
Familie Arenaviridae. *Genus Hartmanivirus, mit Species Haartman-Institut-Schlangen-Virus. *Genus Mammarenavirus (früher ...
Mononegavirales adalah ordo virus RNA yang berada dalam filum Negarnaviricota dan kelas Monjiviricetes.[1] Nama Mononegavirales berasa dari bahasa Yunani μóνος [monos] yang merujuk pada genom untai tunggal pada sebagian besar ordo ini, bahasa Latin negare yang merujuk pada sifat sense-negatif genom virus, serta akhiran -virales yang menunjukkan ordo virus.[2] Anggota ordo ini yang dikenal di antaranya virus rabies dan virus Ebola yang dapat menyebabkan penyakit, baik pada manusia maupun hewan. ...
Arenaviridae f.eks. Lassafeber. *Poxviridae f.eks. kopper. *Retroviridae f.eks. HIV ...
沙状病毒科 Arenaviridae. *本雅病毒科 Bunyaviridae ...
沙状病毒科 Arenaviridae. *本雅病毒科 Bunyaviridae ...
The Lassa virus is a member of the Arenaviridae family of viruses.[1] ...
When retroviruses have integrated their own genome into the germ line, their genome is passed on to a following generation. These endogenous retroviruses (ERVs), contrasted with exogenous ones, now make up 5-8% of the human genome.[7] Most insertions have no known function and are often referred to as "junk DNA". However, many endogenous retroviruses play important roles in host biology, such as control of gene transcription, cell fusion during placental development in the course of the germination of an embryo, and resistance to exogenous retroviral infection. Endogenous retroviruses have also received special attention in the research of immunology-related pathologies, such as autoimmune diseases like multiple sclerosis, although endogenous retroviruses have not yet been proven to play any causal role in this class of disease.[8] While transcription was classically thought to occur only from DNA to RNA, reverse transcriptase transcribes RNA into DNA. The term "retro" in retrovirus refers to ...
The hepatitis envelope proteins are composed of subunits made from the viral preS1, preS2, and S genes. The L (for "large") envelope protein contains all three subunits. The M (for "medium") protein contains only preS2 and S. The S (for "small") protein contains only S. The genome portions encoding these envelope protein subuntis share both the same frame and the same stop codon (generating nested transcripts on a single open reading frame. The pre-S1 is encoded first (closest to the 5' end), followed directly by the pre-S2 and the S. When a transcript is made from the beginning of the pre-S1 region, all three genes are included in the transcript and the L protein is produced. When the transcript starts after the pro-S1 at the beginning of the pre-S2 the final protein contains the pre-S2 and S subunits only and therefore is an M protein. The smallest envelope protein containing just the S subunit is made most because it is encoded closest to the 3' end and comes from the shortest transcript. ...
Viruses in Betanodavirus are non-enveloped, with icosahedral geometries, and T=3 symmetry. The diameter is around 30 nm. Genomes are linear and segmented, bipartite, around 21.4kb in length.[8]. The crystal structure of a betanodavirus- T=3 Grouper nervous necrosis virus (GNNV)-like particle has been determined by X-ray crystallography. The virus-like particle contains 180 subunits of the capsid protein, and each capsid protein (CP) shows three major domains: (i) the N-terminal arm, an inter-subunit extension at the inner surface; (ii) the shell domain (S-domain), a jelly-roll structure; and (iii) the protrusion domain (P-domain) formed by three-fold trimeric protrusions. [10]. ...
Nucleic acid analysis suggests a very long association of the viruses with the wasps (greater than 70 million years).. Two proposals have been advanced for how the wasp/virus association developed. The first suggests that the virus is derived from wasp genes. Many parasitoids that do not use PDVs inject proteins that provide many of the same functions, that is, a suppression of the immune response to the parasite egg. In this model, the braconid and ichneumonid wasps packaged genes for these functions into the viruses-essentially creating a gene-transfer system that results in the caterpillar producing the immune-suppressing factors. In this scenario, the PDV structural proteins (capsids) were probably "borrowed" from existing viruses.. The alternative proposal suggests that ancestral wasps developed a beneficial association with an existing virus that eventually led to the integration of the virus into the wasp's genome. Following integration, the genes responsible for virus replication and the ...
Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
Louis Pasteur was unable to find a causative agent for rabies and speculated about a pathogen too small to be detected using a microscope.[21] In 1884, the French microbiologist Charles Chamberland invented a filter (known today as the Chamberland filter or the Pasteur-Chamberland filter) with pores smaller than bacteria. Thus, he could pass a solution containing bacteria through the filter and completely remove them from the solution.[22] In 1892, the Russian biologist Dmitri Ivanovsky used this filter to study what is now known as the tobacco mosaic virus. His experiments showed that crushed leaf extracts from infected tobacco plants remain infectious after filtration. Ivanovsky suggested the infection might be caused by a toxin produced by bacteria, but did not pursue the idea.[23] At the time it was thought that all infectious agents could be retained by filters and grown on a nutrient medium - this was part of the germ theory of disease.[2] In 1898, the Dutch microbiologist Martinus ...
Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
The Herpesvirales naming system originated in 1973 and has been elaborated considerably since. All herpesviruses described since this system was adopted have been named in accordance with it. The recommended naming system specifies that each species name consists of three parts: a first word, a second word, and finally a number. The first word should be derived from the taxon (family or subfamily) to which its primary natural host belongs. The subfamily name is used for viruses from members of the family Bovidae or from primates (the virus name ending in -ine, e.g. bovine), and the host family name for other viruses (ending in -id, e.g. equid). Human herpesviruses have been treated as an exception (human rather than hominid). Following the host-derived term, species in the family Herpesviridae, which are divided into subfamilies Alphaherpesvirinae, Betaherpesvirinae, and Gammaherpesvirinae, will have the word alphaherpesvirus, betaherpesvirus, or gammaherpesvirus added, respectively. Species in ...
Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
Despite his other successes, Louis Pasteur (1822-1895) was unable to find a causative agent for rabies and speculated about a pathogen too small to be detected using a microscope.[1] In 1884, the French microbiologist Charles Chamberland (1851-1931) invented a filter - known today as the Chamberland filter - that had pores smaller than bacteria. Thus, he could pass a solution containing bacteria through the filter and completely remove them from the solution.[2] In 1876, Adolf Mayer, who directed the Agricultural Experimental Station in Wageningen was the first to show that what he called "Tobacco Mosaic Disease" was infectious, he thought that it was caused by either a toxin or a very small bacterium. Later, in 1892, the Russian biologist Dmitry Ivanovsky (1864-1920) used a Chamberland filter to study what is now known as the tobacco mosaic virus. His experiments showed that crushed leaf extracts from infected tobacco plants remain infectious after filtration. Ivanovsky suggested the infection ...
Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
Gammaherpesviruses are of primary interest due to the two human viruses, EBV and KSHV and the diseases they cause. The gammaherpesviruses replicate and persist in lymphoid cells but some are capable of undergoing lytic replication in epithelial or fibroblast cells. Gammaherpesviruses may be a cause of chronic fibrotic lung diseases in humans and in animals.[10] Murid herpesvirus 68 is an important model system for the study of gammaherpesviruses with tractable genetics. The gammaherpesviruses, including HVS, EBV, KSHV, and RRV, are capable of establishing latent infection in lymphocytes.[9] Attenuated virus mutants represent a promising approach towards gamma-herpesvirus infection control. Surprisingly, latency-deficient and, therefore, apathogenic MHV-68 mutants are found to be highly effective vaccines against these viruses.[8] Research in this area is almost exclusively performed using MHV68 as KSHV and EBV (the major human pathogens of this family) do not productively infect model organisms ...
The Birnaviridae genome encodes several proteins: Birnaviridae RNA-directed RNA polymerase (VP1), which lacks the highly conserved Gly-Asp-Asp (GDD) sequence, a component of the proposed catalytic site of this enzyme family that exists in the conserved motif VI of the palm domain of other RNA-directed RNA polymerases.[3] The large RNA segment, segment A, of birnaviruses codes for a polyprotein (N-VP2-VP4-VP3-C) [4] that is processed into the major structural proteins of the virion: VP2, VP3 (a minor structural component of the virus), and into the putative protease VP4.[4] VP4 protein is involved in generating VP2 and VP3.[4] recombinant VP3 is more immunogenic than recombinant VP2.[5] Infectious pancreatic necrosis virus (IPNV), a birnavirus, is an important pathogen in fish farms. Analyses of viral proteins showed that VP2 is the major structural and immunogenic polypeptide of the virus.[6][7] All neutralizing monoclonal antibodies are specific to VP2 and bind to continuous or discontinuous ...
The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. ... The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. ... By the 1960s, several similar viruses had been discovered and they were classified into the new family Arenaviridae. Since ...
Difference between revisions of "Arenaviridae". From MicrobeWiki, the student-edited microbiology resource ... Retrieved from "https://microbewiki.kenyon.edu/index.php?title=Arenaviridae&oldid=3355" ...
Browse by Exposure: Arenaviridae (2 articles). % of records by year: 1965 2017 ...
Browse by Outcome: Arenaviridae Infections (2 articles). % of records by year: 1965 2017 ...
Merck & Co., Inc., Kenilworth, NJ, USA is a global healthcare leader working to help the world be well. From developing new therapies that treat and prevent disease to helping people in need, we are committed to improving health and well-being around the world. The Merck Manual was first published in 1899 as a service to the community. The legacy of this great resource continues as the Merck Manual in the US and Canada and the MSD Manual outside of North America. Learn more about our commitment to Global Medical Knowledge.. ...
What is Arenaviridae infections? Meaning of Arenaviridae infections medical term. What does Arenaviridae infections mean? ... Looking for online definition of Arenaviridae infections in the Medical Dictionary? Arenaviridae infections explanation free. ... See Arenaviridae. A·re·na·vi·rus. (ă-rēnă-vīrŭs) A genus in the family Arenaviridae that is associated with lymphocytic ... redirected from Arenaviridae infections). Also found in: Dictionary, Thesaurus. arenavirus. [ah-re´nah-vi″rus] any member of a ...
"Arenaviridae Infections" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... This graph shows the total number of publications written about "Arenaviridae Infections" by people in this website by year, ... Below are the most recent publications written about "Arenaviridae Infections" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Arenaviridae Infections". ...
f Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral ...
In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently ... In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently ... This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the ... This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the ...
Viruses from the Arenaviridae family, to which Lujo virus belongs, almost always have a rodent reservoir, with one virus in the ... Lujo is a bisegmented RNA virus-a member of the family Arenaviridae-and a known cause of viral hemorrhagic fever (VHF) in ... "Arenaviridae". International Committee on Taxonomy of Viruses (ICTV). Retrieved 18 December 2018. "Lujo Hemorrhagic Fever (LUHF ...
Viral Zone "Arenaviridae" Zhou, X; Ramachaundran, S; Mann, M; Popkin, DL (2012). "Role of Lymphocytic Choriomeningitis virus( ... Viral Zone "Arenaviridae". Hill, A. Edward (1948). "Benign lymphocytic meningitis". Caribbean Medical Journal. XI (1): 34-7. ... Its causative agent is lymphocytic choriomeningitis mammarenavirus (LCMV), a member of the family Arenaviridae. The name was ... Virus Pathogen Database and Analysis Resource (ViPR): Arenaviridae Palacios, Druce, Du, Tran, Birch, Briese, Conlan, Quan, Hui ...
The continuous growth of knowledege makes it very difficult for scientists to retrieve comprehensive and accurate data on viruses. The desired information is often dispersed in a variety of books, jou
Arenaviridae. Arenaviridae are spread to humans by rodent contact and include Lassa virus in Africa and several rare South ... Lassa virus is the most clinically significant of the Arenaviridae, accounting for serious morbidity and mortality in West ... Four viral families are known to cause VHFs in humans: Arenaviridae, Bunyaviridae, Filoviridae, and Flaviviridae. General ...
Family Arenaviridae. Organ and tissue transplantation have become relatively common surgical procedures, and on rare occasions ... and identified by EM as belonging to the family Arenaviridae. IFA assay and PCR showed that the agent was lymphocytic ...
Arenaviridae. *Viral hemorrhagic fevers: Lassa fever *LASV. *Venezuelan hemorrhagic fever *GTOV. *Argentine hemorrhagic fever * ...
Arenaviridae. Lymphocytic choriomeningitis and Lassa fever viruses. Rhabdoviridae. Rabies virus. Filoviridae. Marburg and Ebola ...
The ARC houses reference quantities of reagents and reference viruses that can be distributed to research and commercial laboratories. The collection also serves as an arbovirus repository for reference strains.
Arenaviridae. (redirected from arenavirus). Also found in: Dictionary, Thesaurus, Medical, Wikipedia.. Related to arenavirus: ... Arenaviridae. [ə‚rēn·ə′vī·rə‚dē] (virology) A family of ribonucleic acid animal viruses consisting of a single genus, ...
Arenaviridae Genus. Arenavirus Information From. J.P. Digoutte Address. Institut Pasteur B.P. 304 Cayenne Guyane Francaise ...
Arenaviridae Lassa fever virus. primates. hemorrhagic fever. ds RNA. +/-. Reoviridae Rice dwarf virus. plants. stunting. ...
Arenaviridae, Rhabdoviridae, Coronaviridae, Bunyaviridae, and Retroviridae. For example, it is intended that the present ...
Tacaribe virus (Arenaviridae) Toxoplasmosis. Additional Tick/Vector Borne Diseases in Florida. Avian influenza ...
Familie Arenaviridae. *Genus Hartmanivirus, mit Species Haartman-Institut-Schlangen-Virus. *Genus Mammarenavirus (früher ...
Arenaviridae 24. Coronaviridae 25. Arteriviridae 26. Picornaviridae 27. Caliciviridae 28. Astroviridae 29. Togaviridae 30. ...
Family Arenaviridae Evolution of Minus-Strand RNA Viruses Further Reading 5. Viruses Whose Life Cycle Uses Reverse ...
Family Arenaviridae 379. Family Togaviridae 381. Family Arteriviridae 384. Family Bornaviridae 386 ...
Negative strand RNA virus families include, but are not limited to, Orthomyxoviridae, Arenaviridae, and Bunyaviridae. ... Arenaviridae or Bunyaviridae (Roberts, A. & Rose, J. K., Virology 1998, 247:1-6; Bridgen & Elliot, Proc. Natl. Acad. Sci. USA ... the arenaviridae family, coronaviridae family, poliovirus family or the rhabdovirus family. The invention advantageously ...
Arenaviridae, Rhabdoviridae, Paramyxoviridae, and Coronaviridae [19, 20] (Table 3.1). In this section we will provide key ...
Arenaviridae. Lymphocytic choriomeningitis. Enveloped. Complex. ss. virus. 6.. Retroviridae. HIV-1, HIV-2, HTLV-I. Enveloped. ...
  • The family Arenaviridae consists of a single genus ( Arenavirus ) composed of at least 24 viruses ( 2 , 3 ). (pnas.org)
  • a genus of viruses of the family Arenaviridae that includes lymphocytic choriomeningitic (LCM) virus, Lassa virus, and viruses of the Tacaribe complex. (thefreedictionary.com)
  • The single genus of the family Arenaviridae, which includes Lassa virus, lymphocytic choriomeningitis virus and the Tacaribe group of haemorrhagic fever (e.g. (thefreedictionary.com)
  • Virology The single genus of the family Arenaviridae, which includes Lassa virus, lymphocytic choriomeningitis virus and hemorrhagic fever-eg Junin, Machupo-viruses Vector Rodents. (thefreedictionary.com)
  • Any of the family of Arenaviridae of viruses which includes those causing LASSA FEVER and LYMPHOCYTIC CHORIOMENINGITIS . (thefreedictionary.com)
  • Arenaviridae are spread to humans by rodent contact and include Lassa virus in Africa and several rare South American hemorrhagic fevers such as Machupo, Junin, Guanarito, and Sabia. (medscape.com)
  • Lassa virus is the most clinically significant of the Arenaviridae, accounting for serious morbidity and mortality in West Africa. (medscape.com)
  • The virus, a member of the virus family Arenaviridae, causes Lassa fever. (allafrica.com)
  • Lassa Fever is caused by the Lassa virus belonging to the Arenaviridae family. (iamat.org)
  • By the 1960s, several similar viruses had been discovered and they were classified into the new family Arenaviridae . (cdc.gov)
  • Arenaviruses (family Arenaviridae) are primarily rodent-borne RNA viruses. (thefreelibrary.com)
  • Arenaviridae Infections" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Arenaviridae Infections" by people in this website by year, and whether "Arenaviridae Infections" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Arenaviridae Infections" by people in Profiles. (umassmed.edu)
  • In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. (uzh.ch)
  • Genus Tequatrovirus ( T4virus , T4-ähnliche Viren , en. (wikipedia.org)
  • This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future. (uzh.ch)
  • Lujo is a bisegmented RNA virus-a member of the family Arenaviridae-and a known cause of viral hemorrhagic fever (VHF) in humans. (wikipedia.org)
  • are·na·vi·rus/ ( ah-re´nah-vi″rus ) any virus of the family Arenaviridae. (thefreedictionary.com)
  • a virus in the family arenaviridae . (thefreedictionary.com)
  • Virus diseases caused by the ARENAVIRIDAE. (umassmed.edu)
  • Pirital virus (Arenaviridae) infection in the syrian golden hamster, Mesocricetus auratus: a new animal model for arenaviral hemorrhagic fever. (ajtmh.org)
  • Viruses from the Arenaviridae family, to which Lujo virus belongs, almost always have a rodent reservoir, with one virus in the family having a bat reservoir. (wikipedia.org)
  • ICTV Virus Taxonomy Profile: Arenaviridae. (nih.gov)
  • The Arenaviridae family , whose prototype is lymphocytic chorio-meningitis virus (LCMV), contains more than 20 members with diverse geographical distributions [ 1 ]. (mdpi.com)
  • En biologisk virus består af et genom af DNA eller RNA og et antal enzymer, der er indlejret i en proteinkappe (kaldet en kapsid ), eventuelt omkrandset af membrankappe . (wikipedia.org)
  • Virus kan ikke formere sig alene, men overtager i stedet for en værtscelle og underkaster værtscellens molekylære maskineri for at fremstille kopier af sig selv og således producere den næste generation. (wikipedia.org)
  • Derfor bliver virus typisk ikke betragtet som levende organismer, fordi de alene ikke kan formere sig eller lave stofskifte , men kræver en vært . (wikipedia.org)
  • Dog har nye genetiske undersøgelser ændret på denne opfattelse, da det har vist sig at virus nedstammer fra en fælles stamform med moderne celler og har været en faktor, der har præget evolutionen . (wikipedia.org)
  • Virus består af et genom og nogle gange et par enzymer , der er indlejret i en proteinkappe (kaldet en kapsid ), eventuelt omkranset af membrankappe (en lipid-membran, eng. (wikipedia.org)
  • Virus kan ikke formere sig alene, men overtager i stedet for en værtscelle, dvs. (wikipedia.org)
  • Arenaviridae comprises 23 recognized virus species with a bipartite ssRNA genome and an ambisense coding strategy. (hindawi.com)
  • Experimental infection of Neotoma albigula (Muridae) with Whitewater Arroyo virus (Arenaviridae). (thefreedictionary.com)
  • The virus is a single-stranded RNA virus belonging to the virus family Arenaviridae . (who.int)
  • Its causative agent is lymphocytic choriomeningitis mammarenavirus (LCMV), a member of the family Arenaviridae. (wikipedia.org)
  • Based on nucleotide sequence data, a better comprehension of the taxonomy and evolution of the Arenaviridae has been achieved. (hindawi.com)
  • The Arenaviridae are a family of viruses whose members are generally associated with rodent-transmitted diseases in humans. (cdc.gov)
  • Arenaviridae are RNA viruses whose particles are spherical and have an average diameter of 110-130 nanometers. (tolweb.org)
  • Members of the Arenaviridae family were subdivided into two groups based on the geographical site of isolation, serological cross-reactivity and genetic data. (hindawi.com)
  • Arenaviridae members are zoonotic, which means that in nature they are found in reservoir animal hosts. (tolweb.org)
  • Arenaviridae is a family composed of a growing number of enveloped viruses with a bipartite single stranded RNA genome. (hindawi.com)