Cerebral Cortex: The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.Cerebral Arteries: The arterial blood vessels supplying the CEREBRUM.Prefrontal Cortex: The rostral part of the frontal lobe, bounded by the inferior precentral fissure in humans, which receives projection fibers from the MEDIODORSAL NUCLEUS OF THE THALAMUS. The prefrontal cortex receives afferent fibers from numerous structures of the DIENCEPHALON; MESENCEPHALON; and LIMBIC SYSTEM as well as cortical afferents of visual, auditory, and somatic origin.Visual Cortex: Area of the OCCIPITAL LOBE concerned with the processing of visual information relayed via VISUAL PATHWAYS.Brain: The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).Motor Cortex: Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.Cerebrovascular Circulation: The circulation of blood through the BLOOD VESSELS of the BRAIN.Somatosensory Cortex: Area of the parietal lobe concerned with receiving sensations such as movement, pain, pressure, position, temperature, touch, and vibration. It lies posterior to the central sulcus.Auditory Cortex: The region of the cerebral cortex that receives the auditory radiation from the MEDIAL GENICULATE BODY.Cerebral Palsy: A heterogeneous group of nonprogressive motor disorders caused by chronic brain injuries that originate in the prenatal period, perinatal period, or first few years of life. The four major subtypes are spastic, athetoid, ataxic, and mixed cerebral palsy, with spastic forms being the most common. The motor disorder may range from difficulties with fine motor control to severe spasticity (see MUSCLE SPASTICITY) in all limbs. Spastic diplegia (Little disease) is the most common subtype, and is characterized by spasticity that is more prominent in the legs than in the arms. Pathologically, this condition may be associated with LEUKOMALACIA, PERIVENTRICULAR. (From Dev Med Child Neurol 1998 Aug;40(8):520-7)Neurons: The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.Middle Cerebral Artery: The largest of the cerebral arteries. It trifurcates into temporal, frontal, and parietal branches supplying blood to most of the parenchyma of these lobes in the CEREBRAL CORTEX. These are the areas involved in motor, sensory, and speech activities.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Infarction, Middle Cerebral Artery: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.Brain Mapping: Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Malaria, Cerebral: A condition characterized by somnolence or coma in the presence of an acute infection with PLASMODIUM FALCIPARUM (and rarely other Plasmodium species). Initial clinical manifestations include HEADACHES; SEIZURES; and alterations of mentation followed by a rapid progression to COMA. Pathologic features include cerebral capillaries filled with parasitized erythrocytes and multiple small foci of cortical and subcortical necrosis. (From Adams et al., Principles of Neurology, 6th ed, p136)Entorhinal Cortex: Cerebral cortex region on the medial aspect of the PARAHIPPOCAMPAL GYRUS, immediately caudal to the OLFACTORY CORTEX of the uncus. The entorhinal cortex is the origin of the major neural fiber system afferent to the HIPPOCAMPAL FORMATION, the so-called PERFORANT PATHWAY.Cerebral Veins: Veins draining the cerebrum.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Neural Pathways: Neural tracts connecting one part of the nervous system with another.Cerebral Hemorrhage: Bleeding into one or both CEREBRAL HEMISPHERES including the BASAL GANGLIA and the CEREBRAL CORTEX. It is often associated with HYPERTENSION and CRANIOCEREBRAL TRAUMA.Cerebellar Cortex: The superficial GRAY MATTER of the CEREBELLUM. It consists of two main layers, the stratum moleculare and the stratum granulosum.Kidney Cortex: The outer zone of the KIDNEY, beneath the capsule, consisting of KIDNEY GLOMERULUS; KIDNEY TUBULES, DISTAL; and KIDNEY TUBULES, PROXIMAL.Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Cats: The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Functional Laterality: Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.Frontal Lobe: The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Cerebellum: The part of brain that lies behind the BRAIN STEM in the posterior base of skull (CRANIAL FOSSA, POSTERIOR). It is also known as the "little brain" with convolutions similar to those of CEREBRAL CORTEX, inner white matter, and deep cerebellar nuclei. Its function is to coordinate voluntary movements, maintain balance, and learn motor skills.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)Cerebral Ventricles: Four CSF-filled (see CEREBROSPINAL FLUID) cavities within the cerebral hemispheres (LATERAL VENTRICLES), in the midline (THIRD VENTRICLE) and within the PONS and MEDULLA OBLONGATA (FOURTH VENTRICLE).Animals, Newborn: Refers to animals in the period of time just after birth.Electroencephalography: Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.Hippocampus: A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.Dominance, Cerebral: Dominance of one cerebral hemisphere over the other in cerebral functions.Nerve Tissue ProteinsTelencephalon: The anterior subdivision of the embryonic PROSENCEPHALON or the corresponding part of the adult prosencephalon that includes the cerebrum and associated structures.Parietal Lobe: Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.Photic Stimulation: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Nerve Net: A meshlike structure composed of interconnecting nerve cells that are separated at the synaptic junction or joined to one another by cytoplasmic processes. In invertebrates, for example, the nerve net allows nerve impulses to spread over a wide area of the net because synapses can pass information in any direction.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Neocortex: The largest portion of the CEREBRAL CORTEX in which the NEURONS are arranged in six layers in the mammalian brain: molecular, external granular, external pyramidal, internal granular, internal pyramidal and multiform layers.Adrenal Cortex: The outer layer of the adrenal gland. It is derived from MESODERM and comprised of three zones (outer ZONA GLOMERULOSA, middle ZONA FASCICULATA, and inner ZONA RETICULARIS) with each producing various steroids preferentially, such as ALDOSTERONE; HYDROCORTISONE; DEHYDROEPIANDROSTERONE; and ANDROSTENEDIONE. Adrenal cortex function is regulated by pituitary ADRENOCORTICOTROPIN.Hypoxia, Brain: A reduction in brain oxygen supply due to ANOXEMIA (a reduced amount of oxygen being carried in the blood by HEMOGLOBIN), or to a restriction of the blood supply to the brain, or both. Severe hypoxia is referred to as anoxia, and is a relatively common cause of injury to the central nervous system. Prolonged brain anoxia may lead to BRAIN DEATH or a PERSISTENT VEGETATIVE STATE. Histologically, this condition is characterized by neuronal loss which is most prominent in the HIPPOCAMPUS; GLOBUS PALLIDUS; CEREBELLUM; and inferior olives.Neuroglia: The non-neuronal cells of the nervous system. They not only provide physical support, but also respond to injury, regulate the ionic and chemical composition of the extracellular milieu, participate in the BLOOD-BRAIN BARRIER and BLOOD-RETINAL BARRIER, form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons. Neuroglia have high-affinity transmitter uptake systems, voltage-dependent and transmitter-gated ion channels, and can release transmitters, but their role in signaling (as in many other functions) is unclear.Autoradiography: The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)Brain Edema: Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)Oxygen: An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.Models, Neurological: Theoretical representations that simulate the behavior or activity of the neurological system, processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Synaptosomes: Pinched-off nerve endings and their contents of vesicles and cytoplasm together with the attached subsynaptic area of the membrane of the post-synaptic cell. They are largely artificial structures produced by fractionation after selective centrifugation of nervous tissue homogenates.gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system.Reaction Time: The time from the onset of a stimulus until a response is observed.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Cerebrum: Derived from TELENCEPHALON, cerebrum is composed of a right and a left hemisphere. Each contains an outer cerebral cortex and a subcortical basal ganglia. The cerebrum includes all parts within the skull except the MEDULLA OBLONGATA, the PONS, and the CEREBELLUM. Cerebral functions include sensorimotor, emotional, and intellectual activities.Electric Stimulation: Use of electric potential or currents to elicit biological responses.Prosencephalon: The anterior of the three primitive cerebral vesicles of the embryonic brain arising from the NEURAL TUBE. It subdivides to form DIENCEPHALON and TELENCEPHALON. (Stedmans Medical Dictionary, 27th ed)Analysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Thalamus: Paired bodies containing mostly GRAY MATTER and forming part of the lateral wall of the THIRD VENTRICLE of the brain.Neuronal Plasticity: The capacity of the NERVOUS SYSTEM to change its reactivity as the result of successive activations.Gyrus Cinguli: One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.Temporal Lobe: Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.Macaca: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of 16 species inhabiting forests of Africa, Asia, and the islands of Borneo, Philippines, and Celebes.Vibrissae: Stiff hairs projecting from the face around the nose of most mammals, acting as touch receptors.Anterior Cerebral Artery: Artery formed by the bifurcation of the internal carotid artery (CAROTID ARTERY, INTERNAL). Branches of the anterior cerebral artery supply the CAUDATE NUCLEUS; INTERNAL CAPSULE; PUTAMEN; SEPTAL NUCLEI; GYRUS CINGULI; and surfaces of the FRONTAL LOBE and PARIETAL LOBE.Tomography, Emission-Computed: Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.Cerebral Amyloid Angiopathy: A heterogeneous group of sporadic or familial disorders characterized by AMYLOID deposits in the walls of small and medium sized blood vessels of CEREBRAL CORTEX and MENINGES. Clinical features include multiple, small lobar CEREBRAL HEMORRHAGE; cerebral ischemia (BRAIN ISCHEMIA); and CEREBRAL INFARCTION. Cerebral amyloid angiopathy is unrelated to generalized AMYLOIDOSIS. Amyloidogenic peptides in this condition are nearly always the same ones found in ALZHEIMER DISEASE. (from Kumar: Robbins and Cotran: Pathologic Basis of Disease, 7th ed., 2005)Subarachnoid Hemorrhage: Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status.Neuroprotective Agents: Drugs intended to prevent damage to the brain or spinal cord from ischemia, stroke, convulsions, or trauma. Some must be administered before the event, but others may be effective for some time after. They act by a variety of mechanisms, but often directly or indirectly minimize the damage produced by endogenous excitatory amino acids.Posterior Cerebral Artery: Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.Psychomotor Performance: The coordination of a sensory or ideational (cognitive) process and a motor activity.Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.Blood Flow Velocity: A value equal to the total volume flow divided by the cross-sectional area of the vascular bed.Pyramidal Cells: Projection neurons in the CEREBRAL CORTEX and the HIPPOCAMPUS. Pyramidal cells have a pyramid-shaped soma with the apex and an apical dendrite pointed toward the pial surface and other dendrites and an axon emerging from the base. The axons may have local collaterals but also project outside their cortical region.Basal Ganglia: Large subcortical nuclear masses derived from the telencephalon and located in the basal regions of the cerebral hemispheres.Cerebrovascular Disorders: A spectrum of pathological conditions of impaired blood flow in the brain. They can involve vessels (ARTERIES or VEINS) in the CEREBRUM, the CEREBELLUM, and the BRAIN STEM. Major categories include INTRACRANIAL ARTERIOVENOUS MALFORMATIONS; BRAIN ISCHEMIA; CEREBRAL HEMORRHAGE; and others.Pia Mater: The innermost layer of the three meninges covering the brain and spinal cord. It is the fine vascular membrane that lies under the ARACHNOID and the DURA MATER.Occipital Lobe: Posterior portion of the CEREBRAL HEMISPHERES responsible for processing visual sensory information. It is located posterior to the parieto-occipital sulcus and extends to the preoccipital notch.Astrocytes: A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.Mice, Inbred C57BLVisual Pathways: Set of cell bodies and nerve fibers conducting impulses from the eyes to the cerebral cortex. It includes the RETINA; OPTIC NERVE; optic tract; and geniculocalcarine tract.Intracranial Embolism and Thrombosis: Embolism or thrombosis involving blood vessels which supply intracranial structures. Emboli may originate from extracranial or intracranial sources. Thrombosis may occur in arterial or venous structures.Action Potentials: Abrupt changes in the membrane potential that sweep along the CELL MEMBRANE of excitable cells in response to excitation stimuli.Macaca fascicularis: A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.Blood-Brain Barrier: Specialized non-fenestrated tightly-joined ENDOTHELIAL CELLS with TIGHT JUNCTIONS that form a transport barrier for certain substances between the cerebral capillaries and the BRAIN tissue.Corpus Striatum: Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.Acoustic Stimulation: Use of sound to elicit a response in the nervous system.Visual Perception: The selecting and organizing of visual stimuli based on the individual's past experience.Axons: Nerve fibers that are capable of rapidly conducting impulses away from the neuron cell body.Rats, Long-Evans: An outbred strain of rats developed in 1915 by crossing several Wistar Institute white females with a wild gray male. Inbred strains have been derived from this original outbred strain, including Long-Evans cinnamon rats (RATS, INBRED LEC) and Otsuka-Long-Evans-Tokushima Fatty rats (RATS, INBRED OLETF), which are models for Wilson's disease and non-insulin dependent diabetes mellitus, respectively.Synapses: Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions.Tissue Distribution: Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.Nervous System Malformations: Structural abnormalities of the central or peripheral nervous system resulting primarily from defects of embryogenesis.Evoked Potentials: Electrical responses recorded from nerve, muscle, SENSORY RECEPTOR, or area of the CENTRAL NERVOUS SYSTEM following stimulation. They range from less than a microvolt to several microvolts. The evoked potential can be auditory (EVOKED POTENTIALS, AUDITORY), somatosensory (EVOKED POTENTIALS, SOMATOSENSORY), visual (EVOKED POTENTIALS, VISUAL), or motor (EVOKED POTENTIALS, MOTOR), or other modalities that have been reported.Alzheimer Disease: A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)Interneurons: Most generally any NEURONS which are not motor or sensory. Interneurons may also refer to neurons whose AXONS remain within a particular brain region in contrast to projection neurons, which have axons projecting to other brain regions.Neurogenesis: Formation of NEURONS which involves the differentiation and division of STEM CELLS in which one or both of the daughter cells become neurons.Parvalbumins: Low molecular weight, calcium binding muscle proteins. Their physiological function is possibly related to the contractile process.Reperfusion: Restoration of blood supply to tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. It is primarily a procedure for treating infarction or other ischemia, by enabling viable ischemic tissue to recover, thus limiting further necrosis. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing REPERFUSION INJURY.Gerbillinae: A subfamily of the Muridae consisting of several genera including Gerbillus, Rhombomys, Tatera, Meriones, and Psammomys.Neural Inhibition: The function of opposing or restraining the excitation of neurons or their target excitable cells.Corpus Callosum: Broad plate of dense myelinated fibers that reciprocally interconnect regions of the cortex in all lobes with corresponding regions of the opposite hemisphere. The corpus callosum is located deep in the longitudinal fissure.Cortical Spreading Depression: The decrease in neuronal activity (related to a decrease in metabolic demand) extending from the site of cortical stimulation. It is believed to be responsible for the decrease in cerebral blood flow that accompanies the aura of MIGRAINE WITH AURA. (Campbell's Psychiatric Dictionary, 8th ed.)Intracranial Pressure: Pressure within the cranial cavity. It is influenced by brain mass, the circulatory system, CSF dynamics, and skull rigidity.Spectroscopy, Near-Infrared: A noninvasive technique that uses the differential absorption properties of hemoglobin and myoglobin to evaluate tissue oxygenation and indirectly can measure regional hemodynamics and blood flow. Near-infrared light (NIR) can propagate through tissues and at particular wavelengths is differentially absorbed by oxygenated vs. deoxygenated forms of hemoglobin and myoglobin. Illumination of intact tissue with NIR allows qualitative assessment of changes in the tissue concentration of these molecules. The analysis is also used to determine body composition.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Carbon Dioxide: A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.Radioligand Assay: Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Memory: Complex mental function having four distinct phases: (1) memorizing or learning, (2) retention, (3) recall, and (4) recognition. Clinically, it is usually subdivided into immediate, recent, and remote memory.Limbic System: A set of forebrain structures common to all mammals that is defined functionally and anatomically. It is implicated in the higher integration of visceral, olfactory, and somatic information as well as homeostatic responses including fundamental survival behaviors (feeding, mating, emotion). For most authors, it includes the AMYGDALA; EPITHALAMUS; GYRUS CINGULI; hippocampal formation (see HIPPOCAMPUS); HYPOTHALAMUS; PARAHIPPOCAMPAL GYRUS; SEPTAL NUCLEI; anterior nuclear group of thalamus, and portions of the basal ganglia. (Parent, Carpenter's Human Neuroanatomy, 9th ed, p744; NeuroNames, http://rprcsgi.rprc.washington.edu/neuronames/index.html (September 2, 1998)).In Situ Hybridization: A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.Brain Stem: The part of the brain that connects the CEREBRAL HEMISPHERES with the SPINAL CORD. It consists of the MESENCEPHALON; PONS; and MEDULLA OBLONGATA.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Cerebral Revascularization: Microsurgical revascularization to improve intracranial circulation. It usually involves joining the extracranial circulation to the intracranial circulation but may include extracranial revascularization (e.g., subclavian-vertebral artery bypass, subclavian-external carotid artery bypass). It is performed by joining two arteries (direct anastomosis or use of graft) or by free autologous transplantation of highly vascularized tissue to the surface of the brain.Afferent Pathways: Nerve structures through which impulses are conducted from a peripheral part toward a nerve center.Synaptic Membranes: Cell membranes associated with synapses. Both presynaptic and postsynaptic membranes are included along with their integral or tightly associated specializations for the release or reception of transmitters.Stroke: A group of pathological conditions characterized by sudden, non-convulsive loss of neurological function due to BRAIN ISCHEMIA or INTRACRANIAL HEMORRHAGES. Stroke is classified by the type of tissue NECROSIS, such as the anatomic location, vasculature involved, etiology, age of the affected individual, and hemorrhagic vs. non-hemorrhagic nature. (From Adams et al., Principles of Neurology, 6th ed, pp777-810)Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Vasospasm, Intracranial: Constriction of arteries in the SKULL due to sudden, sharp, and often persistent smooth muscle contraction in blood vessels. Intracranial vasospasm results in reduced vessel lumen caliber, restricted blood flow to the brain, and BRAIN ISCHEMIA that may lead to hypoxic-ischemic brain injury (HYPOXIA-ISCHEMIA, BRAIN).Physical Stimulation: Act of eliciting a response from a person or organism through physical contact.Regional Blood Flow: The flow of BLOOD through or around an organ or region of the body.Dendrites: Extensions of the nerve cell body. They are short and branched and receive stimuli from other NEURONS.Technetium Tc 99m Exametazime: A gamma-emitting RADIONUCLIDE IMAGING agent used in the evaluation of regional cerebral blood flow and in non-invasive dynamic biodistribution studies and MYOCARDIAL PERFUSION IMAGING. It has also been used to label leukocytes in the investigation of INFLAMMATORY BOWEL DISEASES.Evoked Potentials, Somatosensory: The electric response evoked in the CEREBRAL CORTEX by stimulation along AFFERENT PATHWAYS from PERIPHERAL NERVES to CEREBRUM.Cell Count: The number of CELLS of a specific kind, usually measured per unit volume or area of sample.Serotonin: A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or "seizure disorder."Ferrets: Semidomesticated variety of European polecat much used for hunting RODENTS and/or RABBITS and as a laboratory animal. It is in the subfamily Mustelinae, family MUSTELIDAE.Oximes: Compounds that contain the radical R2C=N.OH derived from condensation of ALDEHYDES or KETONES with HYDROXYLAMINE. Members of this group are CHOLINESTERASE REACTIVATORS.Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Movement: The act, process, or result of passing from one place or position to another. It differs from LOCOMOTION in that locomotion is restricted to the passing of the whole body from one place to another, while movement encompasses both locomotion but also a change of the position of the whole body or any of its parts. Movement may be used with reference to humans, vertebrate and invertebrate animals, and microorganisms. Differentiate also from MOTOR ACTIVITY, movement associated with behavior.Transcranial Magnetic Stimulation: A technique that involves the use of electrical coils on the head to generate a brief magnetic field which reaches the CEREBRAL CORTEX. It is coupled with ELECTROMYOGRAPHY response detection to assess cortical excitability by the threshold required to induce MOTOR EVOKED POTENTIALS. This method is also used for BRAIN MAPPING, to study NEUROPHYSIOLOGY, and as a substitute for ELECTROCONVULSIVE THERAPY for treating DEPRESSION. Induction of SEIZURES limits its clinical usage.Caudate Nucleus: Elongated gray mass of the neostriatum located adjacent to the lateral ventricle of the brain.Thalamic Nuclei: Several groups of nuclei in the thalamus that serve as the major relay centers for sensory impulses in the brain.Neuropsychological Tests: Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.Receptors, GABA-A: Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Electrodes, Implanted: Surgically placed electric conductors through which ELECTRIC STIMULATION is delivered to or electrical activity is recorded from a specific point inside the body.Haplorhini: A suborder of PRIMATES consisting of six families: CEBIDAE (some New World monkeys), ATELIDAE (some New World monkeys), CERCOPITHECIDAE (Old World monkeys), HYLOBATIDAE (gibbons and siamangs), CALLITRICHINAE (marmosets and tamarins), and HOMINIDAE (humans and great apes).Pyramidal Tracts: Fibers that arise from cells within the cerebral cortex, pass through the medullary pyramid, and descend in the spinal cord. Many authorities say the pyramidal tracts include both the corticospinal and corticobulbar tracts.Cognition: Intellectual or mental process whereby an organism obtains knowledge.Atrophy: Decrease in the size of a cell, tissue, organ, or multiple organs, associated with a variety of pathological conditions such as abnormal cellular changes, ischemia, malnutrition, or hormonal changes.Glial Fibrillary Acidic Protein: An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.Muscimol: A neurotoxic isoxazole isolated from species of AMANITA. It is obtained by decarboxylation of IBOTENIC ACID. Muscimol is a potent agonist of GABA-A RECEPTORS and is used mainly as an experimental tool in animal and tissue studies.Electrophysiology: The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.Mice, Neurologic Mutants: Mice which carry mutant genes for neurologic defects or abnormalities.Stereotaxic Techniques: Techniques used mostly during brain surgery which use a system of three-dimensional coordinates to locate the site to be operated on.Brain Infarction: Tissue NECROSIS in any area of the brain, including the CEREBRAL HEMISPHERES, the CEREBELLUM, and the BRAIN STEM. Brain infarction is the result of a cascade of events initiated by inadequate blood flow through the brain that is followed by HYPOXIA and HYPOGLYCEMIA in brain tissue. Damage may be temporary, permanent, selective or pan-necrosis.Synaptic Transmission: The communication from a NEURON to a target (neuron, muscle, or secretory cell) across a SYNAPSE. In chemical synaptic transmission, the presynaptic neuron releases a NEUROTRANSMITTER that diffuses across the synaptic cleft and binds to specific synaptic receptors, activating them. The activated receptors modulate specific ion channels and/or second-messenger systems in the postsynaptic cell. In electrical synaptic transmission, electrical signals are communicated as an ionic current flow across ELECTRICAL SYNAPSES.Choline O-Acetyltransferase: An enzyme that catalyzes the formation of acetylcholine from acetyl-CoA and choline. EC 2.3.1.6.Xenon Radioisotopes: Unstable isotopes of xenon that decay or disintegrate emitting radiation. Xe atoms with atomic weights 121-123, 125, 127, 133, 135, 137-145 are radioactive xenon isotopes.Acetylcholine: A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system.Substantia Innominata: Tissue in the BASAL FOREBRAIN inferior to the anterior perforated substance, and anterior to the GLOBUS PALLIDUS and ansa lenticularis. It contains the BASAL NUCLEUS OF MEYNERT.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Tomography, Emission-Computed, Single-Photon: A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.Embryo, Mammalian: The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Cell Movement: The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.Iofetamine: An amphetamine analog that is rapidly taken up by the lungs and from there redistributed primarily to the brain and liver. It is used in brain radionuclide scanning with I-123.Evoked Potentials, Visual: The electric response evoked in the cerebral cortex by visual stimulation or stimulation of the visual pathways.Pentobarbital: A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)Touch: Sensation of making physical contact with objects, animate or inanimate. Tactile stimuli are detected by MECHANORECEPTORS in the skin and mucous membranes.Evoked Potentials, Motor: The electrical response evoked in a muscle or motor nerve by electrical or magnetic stimulation. Common methods of stimulation are by transcranial electrical and TRANSCRANIAL MAGNETIC STIMULATION. It is often used for monitoring during neurosurgery.Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Auditory Perception: The process whereby auditory stimuli are selected, organized, and interpreted by the organism.Microcirculation: The circulation of the BLOOD through the MICROVASCULAR NETWORK.Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)Papio: A genus of the subfamily CERCOPITHECINAE, family CERCOPITHECIDAE, consisting of five named species: PAPIO URSINUS (chacma baboon), PAPIO CYNOCEPHALUS (yellow baboon), PAPIO PAPIO (western baboon), PAPIO ANUBIS (or olive baboon), and PAPIO HAMADRYAS (hamadryas baboon). Members of the Papio genus inhabit open woodland, savannahs, grassland, and rocky hill country. Some authors consider MANDRILLUS a subgenus of Papio.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Basilar Artery: The artery formed by the union of the right and left vertebral arteries; it runs from the lower to the upper border of the pons, where it bifurcates into the two posterior cerebral arteries.Dizocilpine Maleate: A potent noncompetitive antagonist of the NMDA receptor (RECEPTORS, N-METHYL-D-ASPARTATE) used mainly as a research tool. The drug has been considered for the wide variety of neurodegenerative conditions or disorders in which NMDA receptors may play an important role. Its use has been primarily limited to animal and tissue experiments because of its psychotropic effects.Stem Cells: Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.Neuroanatomy: Study of the anatomy of the nervous system as a specialty or discipline.Fetus: The unborn young of a viviparous mammal, in the postembryonic period, after the major structures have been outlined. In humans, the unborn young from the end of the eighth week after CONCEPTION until BIRTH, as distinguished from the earlier EMBRYO, MAMMALIAN.Microdialysis: A technique for measuring extracellular concentrations of substances in tissues, usually in vivo, by means of a small probe equipped with a semipermeable membrane. Substances may also be introduced into the extracellular space through the membrane.Attention: Focusing on certain aspects of current experience to the exclusion of others. It is the act of heeding or taking notice or concentrating.Wakefulness: A state in which there is an enhanced potential for sensitivity and an efficient responsiveness to external stimuli.Brain Damage, Chronic: A condition characterized by long-standing brain dysfunction or damage, usually of three months duration or longer. Potential etiologies include BRAIN INFARCTION; certain NEURODEGENERATIVE DISORDERS; CRANIOCEREBRAL TRAUMA; ANOXIA, BRAIN; ENCEPHALITIS; certain NEUROTOXICITY SYNDROMES; metabolic disorders (see BRAIN DISEASES, METABOLIC); and other conditions.Evoked Potentials, Auditory: The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Amygdala: Almond-shaped group of basal nuclei anterior to the INFERIOR HORN OF THE LATERAL VENTRICLE of the TEMPORAL LOBE. The amygdala is part of the limbic system.Microelectrodes: Electrodes with an extremely small tip, used in a voltage clamp or other apparatus to stimulate or record bioelectric potentials of single cells intracellularly or extracellularly. (Dorland, 28th ed)Forelimb: A front limb of a quadruped. (The Random House College Dictionary, 1980)Guinea Pigs: A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.Xenon: A noble gas with the atomic symbol Xe, atomic number 54, and atomic weight 131.30. It is found in the earth's atmosphere and has been used as an anesthetic.Blood Volume: Volume of circulating BLOOD. It is the sum of the PLASMA VOLUME and ERYTHROCYTE VOLUME.
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Computational analysis of functional connectivity between areas of primate cerebral cortex
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Area and Layer Patterning in the Developing Cerebral Cortex
Area identity shifts in the early cerebral cortex of Emx2-/- mutant mice
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Identification of a population of sleep-active cerebral cortex neurons | PNAS
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Regarding the association areas of the cerebral cortex which of the following statements is most accurate | Gotmyhomework
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PosteriorAmyloid angiopathyNeuronsHemispheresDeveloping Cerebral CortexFunctional AreasOccipitalMammalian cerebralParietalDevelopment of the cerebral cortexLobesStructure of the cerebral cortexSensory cortexInfluence the adrenal medullaMedial entorhinal cortexConnectivityAnatomicalDerived from theThicknessInputsPrimatesNeuronTemporalPhysiologyHuman visual cortexStriateDistinctPlasticityCircuitsDevelopmentalSurface of the cerebralAuditoryRegionsPrimaryBrain'sVisualGyriResearchersMotorClinicalSubdivisionLocalizationLocalisation
Posterior1
- Cerebral microinfarct and white matter disease in CAA have been more often observed in the posterior circulation territory, however the restricted lateralization reported in our case has not been seen. (heighpubs.org)
Amyloid angiopathy4
- Li Y, Al-Salaimeh A, DeGrush E, Moonis M. Lateralized Cerebral Amyloid Angiopathy presenting with recurrent Lacunar Ischemic Stroke. (heighpubs.org)
- Interestingly, the SWAN sequences showed lateralized rather than global multiple microhemorrhages over the right MCA and PCA territory, and the sulcal hyperintensity on FLAIR was also seen with no associated susceptibility effect and minimal enhancement, indicating probable cerebral amyloid angiopathy (CAA) based on Boston Criteria. (heighpubs.org)
- Magnetic Resonance Imaging of lateralized cerebral amyloid angiopathy presented as recurrent ischemic stroke. (heighpubs.org)
- Cerebral amyloid angiopathy (CAA) is characterized by the deposition of fibrillar protein with beta-pleated sheet configuration in the media and adventitia of small cortical and leptomeningeal arteries and capillaries . (heighpubs.org)
Neurons41
- We are only beginning to define the mechanisms that determine the area identity of neurons in the cortex. (bio-medicine.org)
- Emx2 is the gold standard for genes that impart area identity to cortical neurons, says OLeary. (bio-medicine.org)
- So OLeary and his team collaborated with Italian researchers, led by Dr. Michele Studer, who is co-senior author with OLeary of the study, to develop mice in which COUP-TF1 can be selectively removed from progenitor cells in the cortex just before they start generating cortical neurons. (bio-medicine.org)
- While Emx2 works in a positive manner to specify the area identity of visual neurons, the presence of COUP-TF1 prevents progenitor cells from taking on a motor area identity. (bio-medicine.org)
- The total number of neurons to be seen in delimited vertical areas of cortex is remarkably constant in different regions. (brainkart.com)
- The cortex of the visual area is an exception and has a much greater density of neurons than other parts of the cortex. (brainkart.com)
- This applies even to such widely different functions as sensation and motion, for in the cortex the neurons of these are so intimately associated that an insensible transition from one to the other is effected. (humannervoussystem.info)
- Although sleep-active neurons have been identified in other brain areas, neurons that are specifically activated during slow-wave sleep have not previously been described in the cerebral cortex. (pnas.org)
- In the course of these studies, we observed that a population of cerebral cortex neurons which express nNOS showed greatly elevated Fos expression during RS after a period of SD. (pnas.org)
- Neurons in the early zones are thought to play important roles in the formation of the cortex: the Cajal-Retzius cells of the marginal zone are instrumental in neuronal migration and laminar formation, and cells of the subplate are involved in the formation of cortical connections. (jneurosci.org)
- These neurons follow a tangential migratory route to their positions in the developing cortex. (jneurosci.org)
- The hippocampal area Cornu Ammonis (CA) CA2 is important for social interaction and is innervated by Substance P (SP)-expressing supramammillary (SuM) nucleus neurons. (pnas.org)
- The hippocampus consists of Cornu Ammonis (CA) areas CA1, CA2, and CA3, containing pyramidal neurons and the dentate gyrus, containing granule cells. (pnas.org)
- The cerebral cortex of the human brain is a sheet of about 10 billion neurons divided into discrete subdivisions or areas that process particular aspects of sensation, movement, and cognition. (sciencemag.org)
- The new evidence indicates that the development of cortical areas involves a rich array of signals, with considerable interplay between mechanisms intrinsic to cortical progenitors and neurons and mechanisms extrinsic to the cortex, including those requiring neural activity. (sciencemag.org)
- Early development of the cortex is highly integrated with development of other parts of the brain, including midline patterning centers, the basal ganglia primordia that produce many of the cortical local circuit neurons, and axonal inputs from the thalamus and brain stem. (sciencemag.org)
- In the mammalian cerebral cortex neurons are arranged in specific layers and form connections both within the cortex and with other brain regions, thus forming a complex mesh of specialized synaptic connections comprising distinct circuits. (nih.gov)
- In particular, the study of stellate cells (SCs) in medial entorhinal has resulted in discovery of correlations between physiological properties of these neurons and properties of the unique spatial representation that is demonstrated through unit recordings of neurons in medial entorhinal cortex (mEC) from awake-behaving animals. (frontiersin.org)
- The second section focuses upon cholinergic modulation of subthreshold electrophysiological properties of neurons in medial entorhinal cortex (mEC). (frontiersin.org)
- At the cellular and circuit level, the cerebral cortex is characterized by two primary organizational features: across its surface it is divided into functional areas that serve various sensory, motor, and cognitive functions, and it is subdivided into several layers that organize the input and output connectivity of resident neurons. (wikipedia.org)
- After the work of Korbinian Brodmann (1909) the neurons of the cerebral cortex are grouped into six main layers, from outside (pial surface) to inside (white matter): Layer I, the molecular layer, contains few scattered neurons and consists mainly of extensions of apical dendritic tufts of pyramidal neurons and horizontally oriented axons, as well as glial cells. (wikipedia.org)
- Layer V, the internal pyramidal layer, contains large pyramidal neurons which give rise to axons leaving the cortex and running down to subcortical structures (such as the basal ganglia). (wikipedia.org)
- Grey matter is formed by neurons and their unmyelinated fibers, whereas the white matter below the grey matter of the cortex is formed predominantly by myelinated axons interconnecting different regions of the central nervous system . (bionity.com)
- The phylogenetically more ancient part of the cerebral cortex, the hippocampus , is differentiated in five layers of neurons , whereas the more recent neo-cortex is differentiated in six basic layers. (bionity.com)
- In fact, a columnar distribution of neurons displaying similar functional properties throughout the cerebral cortex has been observed by many researchers. (frontiersin.org)
- The columnar organization of the cerebral cortex is a broadly documented principle of design preserved throughout mammalian evolution ( Mountcastle, 1997 ), which has been proposed to be important to allow a large number of neurons to be connected without a significant increase in cortical volume. (frontiersin.org)
- The cerebral cortex resembles a six layer sheet of neurons that in many animals, including humans, is folded to fit into the confines of the skull. (els.net)
- The cerebral cortex is composed of different neuronal subtypes that are organised into networks that connect neurons within and between distinct functional areas. (els.net)
- Neurons with similar properties are arranged in a columnar manner suggesting that single columns containing canonical circuits may be the basic unit of processing in the cerebral cortex. (els.net)
- Functional specialization refers to groups of neurons in areas of the brain that operate together to carry out a specific function. (forbes.com)
- Cortical areas on the lateral surface and the medial wall of the hemisphere are the source of neurons that influence the adrenal medulla. (kurzweilai.net)
- In the case of the brain, the connections are made by neurons that link the sensory inputs and motor outputs with centers in the various lobes of the cerebral cortex. (howstuffworks.com)
- Here, we tested the idea that M1, despite lacking a cytoarchitecturally visible L4, nevertheless possesses its equivalent in the form of excitatory neurons with input-output circuits like those of the L4 neurons in sensory areas. (elifesciences.org)
- Consistent with this idea, we found that neurons located in a thin laminar zone at the L3/5A border in the forelimb area of mouse M1 have multiple L4-like synaptic connections: excitatory input from thalamus, largely unidirectional excitatory outputs to L2/3 pyramidal neurons, and relatively weak long-range corticocortical inputs and outputs. (elifesciences.org)
- Our findings therefore identify pyramidal neurons in M1 with the expected prototypical circuit properties of excitatory L4 neurons, and question the traditional assumption that motor cortex lacks this layer. (elifesciences.org)
- After staining neurons with a dye and studying the structures of the cells and how they were organized, he realized that he could divide the cortex into 43 numbered regions. (elifesciences.org)
- Neurons in the different layers form distinct sets of connections, and the relative thickness of the layers has implications for the function carried out by that area. (elifesciences.org)
- Neurons at the border between layer 3 and layer 5A in the motor cortex possess many of the same properties as the neurons in layer 4 in sensory cortex. (elifesciences.org)
- go on to characterize some of the properties of the neurons in the putative layer 4 of the motor cortex, finding that they do not look like the specialized 'stellate' cells that are found in some other areas of the cortex. (elifesciences.org)
- The brain can be studied on various scales, said researcher David Alexander, Ph.D., of Belgium's University of Leuven: "You have the neurons, the circuits between the neurons, the Brodmann areas - brain areas that correspond to a certain function - and the entire cortex. (psychcentral.com)
- The gray matter of the brain refers to a core area with many cell bodies ( soma ) of neurons, while white matter is made up of bundles of axons running up and down the cord, colored white because most axons are covered with a myelin sheath. (newworldencyclopedia.org)
Hemispheres10
- Human Cerebral Cortex The human cerebrum is divided into two mirror image cerebral hemispheres by. (picsearch.com)
- Primary visual cortex (V1) was clearly identifiable along the calcarine sulcus in all hemispheres. (scirp.org)
- These reach various parts of the cerebral cortex in both hemispheres. (brainkart.com)
- It is also divided into left and right cerebral hemispheres by the longitudinal fissure, but the two hemispheres are joined at the midline by the corpus callosum. (wikipedia.org)
- Major tract of axons that functionally interconnects right and left cerebral hemispheres. (slideshare.net)
- The most-frontal part of the neural tube, the telencephalon , gives rise to the cerebral hemispheres and the neocortex . (bionity.com)
- The cerebral cortex is a telencephalic structure present in some vertebrate species located at the surface of the cerebral hemispheres. (els.net)
- Although structurally similar, the two hemispheres of the cortex are not functionally equivalent. (els.net)
- In a subgroup of 17 boys with autism who have enlarged brains, however, the researchers found increased folding in five areas of the cortex that sit along a line dividing the hemispheres. (scientificamerican.com)
- The two hemispheres of the cerebral cortex are part of the forebrain, which is the largest part of the brain. (mindmeister.com)
Developing Cerebral Cortex1
- Does cell lineage in the developing cerebral cortex contribute to its columnar organization? (frontiersin.org)
Functional Areas5
- Researchers uncover novel mechanism that balances the sizes of functional areas in. (bio-medicine.org)
- Mice without COUP-TF1 have many defects and die a few days after birth before functional areas can be defined, explains co-first author Shen-Ju Chou, a postdoctoral researcher in the OLeary lab. (bio-medicine.org)
- Conical Functional Areas And Vascular Territories Of Cerebral Arteries On The T ransverse Images Of Brain Spect. (cnki.com.cn)
- In this study, we performed diffusion tensor imaging and tractography, together with histological analyses to investigate the emergence of functional areas in the cerebral cortex and their connections in BTBR mice and age-matched C57Bl/6 control mice. (biomedcentral.com)
- The human cerebral cortex is made up of distinct functional areas. (els.net)
Occipital6
- Each cerebral cortex hemisphere is made of four anatomically distinct lobes: frontal, parietal, occipital and temporal. (els.net)
- They have less folding in one spot on the occipital cortex, the brain's visual hub. (scientificamerican.com)
- Visual information is processed in the occipital lobe which is an area of the cerebral cortex in the lower rear of the brain behind the base of the skull. (forbes.com)
- One approach divides the occipital lobe into the striate and extrastriate cortices. (forbes.com)
- Occipital lobe -- The occipital lobe receives and processes visual information directly from the eyes and relates this information to the parietal lobe (Wernicke's area) and motor cortex (frontal lobe). (howstuffworks.com)
- Clear differences are apparent such that MEC is connected preferentially with visual-spatial occipital, parietal and postrhinal/parahippocampal cortices and the pre-parasubiculum, whereas LEC is strongly connected with olfactory, insular, frontal, and perirhinal cortices. (scholarpedia.org)
Mammalian cerebral3
- These results are largely compatible with corresponding analyses of structural data of mammalian cerebral cortex, and deliver the first functional evidence for 'small-world' architecture of primate cerebral cortex. (isi.edu)
- Recent findings implicate embryonic signaling centers in patterning the mammalian cerebral cortex. (biologists.org)
- Normal functioning of the mammalian cerebral cortex depends on the partition of the cortical sheet into different types of cortex, and further subdivision into specialized areas ( Nauta and Feirtag, 1986 ). (biologists.org)
Parietal4
- These disease‐specific differences are initially greatest in temporal and parietal association areas, and spread to engulf the rest of the cortex. (els.net)
- The rear of the parietal lobe (next to the temporal lobe) has a section called Wernicke's area , which is important for understanding the sensory (auditory and visual) information associated with language. (howstuffworks.com)
- Temporal lobe -- The temporal lobe processes auditory information from the ears and relates it to Wernicke's area of the parietal lobe and the motor cortex of the frontal lobe. (howstuffworks.com)
- The somatosensory cortex is in an area of the parietal lobe associated with the interpretation of sensory imput from the body. (prezi.com)
Development of the cerebral cortex1
- Layer I, which plays an important role in the development of the cerebral cortex, expands in size and diversity in primates. (jneurosci.org)
Lobes2
- Within these lobes, different cortical functions are carried out by functionally and anatomically distinct cortical areas. (els.net)
- Letters represent the lobes (areas) of the cerebral cortex, i.e. (redbubble.com)
Structure of the cerebral cortex1
- His wife Cécile and he provided important findings on the structure of the cerebral cortex - and also labored under a misconception or two. (mpg.de)
Sensory cortex2
- Both the sensory cortex and the motor cortex have been mapped out according to what part of the body it controls. (medicalartlibrary.com)
- Body regions with highest densities of receptors are represented by largest areas of sensory cortex. (slideshare.net)
Influence the adrenal medulla1
- This observation," said Dr. Strick, "raises the possibility that activity in these cortical areas when you re-imagine an error, or beat yourself up over a mistake, or think about a traumatic event, results in descending signals that influence the adrenal medulla in just the same way as the actual event. (kurzweilai.net)
Medial entorhinal cortex1
- E . Schematic representation of entorhinal cortex (taken from C) summarizing its main connections with emphasis on the differences between the lateral and medial entorhinal cortex, LEC and MEC respectively, and between the zones that are differently positioned in relation to the rhinal sulcus. (scholarpedia.org)
Connectivity8
- We report here on (1) a summary of the layout of cortical areas associated with vision and with other modalities, (2) a computerized database for storing and representing large amounts of information on connectivity patterns, and (3) the application of these data to the analysis of hierarchical organization of the cerebral cortex. (psu.edu)
- Mature cortical areas differ by their location within the cortex, molecular properties, histological organization, patterns of connectivity, and function. (sciencemag.org)
- These different cortical areas have a precise connectivity, particularly with nuclei within the dorsal thalamus, which provides some of the principal inputs to the cerebral cortex ( Fig. 1 ). (sciencemag.org)
- Each area has its own unique structural-functional criteria and connectivity. (i4u.com)
- We demonstrate that interhemispheric connectivity and cortical area formation are altered in an age- and region-specific manner in BTBR mice, which may contribute to the behavioural deficits previously observed in this strain. (biomedcentral.com)
- Here we targeted high-level category-selective visual areas and tested this prediction by comparing BOLD functional connectivity patterns formed during rest to patterns formed in response to naturalistic stimuli, as well as to more artificial category-selective, dynamic stimuli. (weizmann.ac.il)
- Connectivity relationships between areas is just what it sounds like. (forbes.com)
- Figure 1: Schematic representation of the entorhinal cortex and its main connectivity illustrating its pivotal position to mediate the communication between the hippocampal formation and neocortex. (scholarpedia.org)
Anatomical2
- Here we have attempted to determine a graded parameter describing the anatomical relationship of interconnected areas. (psu.edu)
- In fact, the anatomical observation of discontinuous architectural features of cerebral cortex uncovered very early by Ramón y Cajal and Lorente de Nó was followed by the realization that a functional architecture was also present probably as an emerging property of the underlying anatomical architecture. (frontiersin.org)
Derived from the1
- To test this hypothesis, cells derived from the hypothalamus-preoptic area (HPOA) and cerebral cortex (CTX) of lamb fetuses were grown in primary culture to examine the direct morphological effects of testosterone on these cellular components. (oregonstate.edu)
Thickness9
- Joint Analysis of Cortical Area and Thickness as a Replacement for the Analysis of the Volume of the Cerebral Cortex. (ox.ac.uk)
- In addition, focusing on the joint analysis of thickness and area, we compare an improved, analytic method for measuring cortical volume to a permutation-based nonparametric combination (NPC) method. (ox.ac.uk)
- We use the methods to analyze area, thickness and volume in young adults born preterm with very low birth weight, and show that NPC analysis is a more sensitive option for studying joint effects on area and thickness, giving equal weight to variation in both of these 2 morphological features. (ox.ac.uk)
- Recently, it was found that the thickness of the cortex in the FFA predicts the ability to recognize faces as well as vehicles. (wikipedia.org)
- We also found that both the primary visual and somatosensory cortical areas are shifted medially in BTBR mice compared to controls and that cortical thickness is differentially altered in BTBR mice between cortical areas and throughout development. (biomedcentral.com)
- The postnatal Brca1 -ablated cerebral cortex was substantially reduced in size with regard to both cortical thickness and surface area. (biologists.org)
- Microstructural architecture such as the thickness of the cortex or the amount of myelin in an area. (forbes.com)
- Unfortunately, a closer look shows that they assumed that the cortical thickness scales with cerebral size by a power law, which is not the case ( 5 ). (sciencemag.org)
- 1) with the exposed cortical surface area, the total cortical surface area, and cortical thickness T . Let us call the dimensionless constant k the "fractal constant. (sciencemag.org)
Inputs5
- Our analysis concentrates on the visual system, which includes 25 neocortical areas that are predominantly or exclusively visual in function, plus an additional 7 areas that we regard as visual-association areas on the basis of their extensive visual inputs. (psu.edu)
- In addition to the striate cortex additional areas of cortex responding to visual inputs are described. (brainkart.com)
- Inputs to the apical tufts are thought to be crucial for the ''feedback interactions in the cerebral cortex involved in associative learning and attention. (wikipedia.org)
- Sensory cortices (visual, auditory and somatosensory) process information received from peripheral sense organs, motor areas plan and instruct motor output and association areas integrate cortical inputs to create meaningful motor outputs and cognitive and emotional constructs. (els.net)
- In contrast to the dogma that all visual areas in the cerebral cortex get their inputs from primary visual cortex (V1), the new study shows that postrhinal cortex (POR) gets information about moving objects via a parallel visual pathway from an evolutionarily ancient brainstem area called superior colliculus. (ucsf.edu)
Primates3
- Organization of the cerebral cortex in the marmoset, one of the smallest simian primates. (picsearch.com)
- Kaas JH, Nelson RJ, Sur M, Lin CS and Merzenich MM (1979) Multiple representations of the body within the primary somatosensory cortex of primates. (els.net)
- Circuits for multisensory integration and attentional modulation through the prefrontal cortex and the thalamic reticular nucleus in primates. (bu.edu)
Neuron1
- Instead, they resemble the 'pyramidal' type of neuron that is found in all layers and areas of the cortex. (elifesciences.org)
Temporal3
- e) Fifth visual area (V5) at the posterior end of the superior temporal gyrus. (brainkart.com)
- They found pronounced folding in temporal and frontal areas close to those in their original sample. (scientificamerican.com)
- The entorhinal cortex is part of the medial temporal lobe or hippocampal memory system and constitutes the major gateway between the hippocampal formation and the neocortex. (scholarpedia.org)
Physiology2
- There is strong evidence to support the claim that acetylcholine modulates the physiology and the function of the entorhinal cortex (EC). (frontiersin.org)
- It's as if we've discovered a second primary visual cortex," said study senior author Massimo Scanziani , PhD, a professor of physiology at UCSF and a Howard Hughes Medical Institute investigator. (ucsf.edu)
Human visual cortex4
- We have used positron emission tomography (PET), which measures regional cerebral blood flow (rCBF), to demonstrate directly the specialization of function in the normal human visual cortex. (psu.edu)
- Dumoulin, S.O. and Wandell, B.A. (2008) Population receptive field estimates in human visual cortex. (scirp.org)
- 2003) Visual field representations and locations of visual areas V1/2/3 in human visual cortex. (scirp.org)
- Brewer, A.A. and Barton, B. (2012) Visual field map organization in human visual cortex. (scirp.org)
Striate3
- 1996) Mapping striate and extrastriate visual areas in human cerebral cortex. (scirp.org)
- It is also called the striate cortex. (brainkart.com)
- The striate cortex is also know as the primary visual cortex, Broadman area 17 and area V1. (forbes.com)
Distinct3
- First, neocortex is divided into anatomically distinct and functionally specialized areas that form a species-specific map. (nih.gov)
- They are expressed in distinct, but often interconnected, areas of the developing nervous system and in some non-neural tissues. (wikipedia.org)
- The motor cortex (M1) is classically considered an agranular area, lacking a distinct layer 4 (L4). (elifesciences.org)
Plasticity1
- de Villers‐Sedani E and Merzenich MM (2011) Lifelong plasticity in the rat auditory cortex: basic mechanisms and the role of sensory experience. (els.net)
Circuits1
- Together with his JMU undergraduate mentees, Dr. Vidal's lab uses cutting-edge neuroscience techniques to understand the roles of autism genetic risk factors as cerebral cortical circuits wire up. (jmu.edu)
Developmental3
- Timeline (grey) of key developmental processes in the rodent cortex from embryonic stages to the end of the first month of life, from neurogenesis, to astrogenesis to synapse formation, maturation and stabilization. (nih.gov)
- c Development of synapses in the mouse visual cortex visualized by electron microscopy at the different developmental ages as labeled. (nih.gov)
- Early developmental disruptions in these areas may magnify the folding over time, she says. (scientificamerican.com)
Surface of the cerebral2
- By the use of these various methods, singly or in combination, it is possible to map out on the surface of the cerebral cortex certain areas with well-defined functions - thus, motor areas, sensory areas, and association areas are described. (humannervoussystem.info)
- The surface of the cerebral cortex is folded in large mammals, wherein more than two-thirds of the cortical surface is buried in the grooves, called "sulci. (bionity.com)
Auditory2
- The auditory area receives auditory information. (medicalartlibrary.com)
- The auditory association area is where sound is interpreted as noise, music or speech. (medicalartlibrary.com)
Regions3
- While it had been known for some time that the types of cells and their arrangement in layers were not exactly alike in all the regions of the cortex, yet it is only within the last few years that careful systematic observations have been inade to determine whether these differences had any definite relation to cortical localisation. (humannervoussystem.info)
- Body regions with the greatest number of motor innervation are represented by largest areas of motor cortex. (slideshare.net)
- Certain regions of the brain's outer layer, the cerebral cortex, are more intricately folded in school-age children and adolescents with autism than they are in controls, according to one of the studies. (scientificamerican.com)
Primary13
- On each lobe , primary sensory areas receive a specific type of sensory. (picsearch.com)
- In normally aging subjects, primary visual cortex has been shown to have reduced responses to visual stimulation . (scirp.org)
- It is not known, however, to what extent aging affects visual field repre-sentations and population receptive sizes in human primary visual cortex. (scirp.org)
- Here we use func-tional MRI (fMRI) and population receptive field (pRF) modeling to measure angular and ec-centric retinotopic representations and population receptive fields in primary visual cortex in healthy aging subjects ages 57 - 70 and in healthy young volunteers ages 24 - 36 (n = 9). (scirp.org)
- Understanding the extent of changes that occur in primary visual cortex during normal aging is essential both for understanding the normal aging process and for comparisons of healthy, aging subjects with aging patients suffering from age-related visual and cortical disorders. (scirp.org)
- The central sulcus divides the primary sensory and motor areas. (medicalartlibrary.com)
- The presence of large-amplitude, slow waves in the EEG is a primary characteristic that distinguishes cerebral activity during sleep from that which occurs during wakefulness. (pnas.org)
- One of the clearest examples of cortical layering is the line of Gennari in the primary visual cortex. (wikipedia.org)
- Primary area responsible for perception of somatesthetic sensation. (slideshare.net)
- Primary area responsible for vision and coordination of eye movements. (slideshare.net)
- Brewer, A. and Barton, B. (2012) Effects of healthy aging on human primary visual cortex. (scirp.org)
- 2008) The effect of age and fixation instability on retinotopic mapping of primary visual cortex. (scirp.org)
- One of these areas is a portion of the primary motor cortex that is concerned with the control of axial body movement and posture. (kurzweilai.net)
Brain's1
- For example, that the brain's speech area is activated when we speak. (psychcentral.com)
Visual19
- The assemblies suggest a principal division of the cortex into visual, somatomotor and orbito-temporo-insular systems, while motor and somatosensory areas are inseparably interrelated. (isi.edu)
- When we increased the amount of Emx2, the visual area expanded at the expense of the frontal and somatosensory areas and vice versa. (bio-medicine.org)
- A novel technique, statistical parametric mapping, was used to detect foci of significant change in cerebral blood flow within the prestriate cortex, in order to localize those parts involved in the perception of color and visual motion. (psu.edu)
- The classical visual area has been described before. (brainkart.com)
- and area 19 ( parastriate area ) is the third visual area. (brainkart.com)
- A modified nomenclature recognising five visual areas has been described as follows. (brainkart.com)
- b) Second visual area (V2) occupying the greater part of area 18, but not the whole of it. (brainkart.com)
- c) Third visual area (V3) occupying a narrow strip over the anterior part of area 18. (brainkart.com)
- The visual areas give off efferent fibres also. (brainkart.com)
- Like other 'sensory' areas the visual areas are, therefore, to be regarded as partly motor in function. (brainkart.com)
- Efferents from the visual areas also reach the superior colliculus, the pretectal region, and the nuclei of cranial nerves supplying muscles that move the eyeballs. (brainkart.com)
- The visual area receives visual stimuli and the visual association area helps to interpret those stimuli. (medicalartlibrary.com)
- spindular/spindle-shaped face area) is a part of the human visual system that is specialized for facial recognition . (wikipedia.org)
- Hubel DH and Wiesel TN (1962) Receptive fields, binocular interaction and functional architecture in the cat's visual cortex. (els.net)
- b P7 mouse visual cortex labeled with DAPI (white) to mark cell nuclei. (nih.gov)
- Astrocytes are present in all cortical layers in the visual cortex. (nih.gov)
- The extrastriate cortex is sometimes called the peristriate cortex and includes areas that are sometimes called Broadman areas 18 and 19, or visual areas V2, V3, V4 and V5. (forbes.com)
- The new study - published online Jan. 4, 2019, in Science - shows for the first time that one of these supposedly higher-order visual areas, which is involved in the perception of moving objects, does not depend on information from V1 at all. (ucsf.edu)
- This undermines the whole concept of the visual system in mammalian cortex as a perfect hierarchy with V1 as the gatekeeper and raises a multitude of questions, including how these two parallel visual systems evolved and how they cooperate to produce a unified visual experience. (ucsf.edu)
Gyri2
Researchers5
- In this weeks advance online edition of Nature Neuroscience, an international collaboration between researchers at the Salk Institute for Biological Studies and the Telethon Institute of Genetics and Medicine in Italy reports the discovery of a novel function for a factor that negotiates the borders between areas and balances their sizes and positions relative to each other. (bio-medicine.org)
- Although the mice lacking COUP-TF1 in their cortex do not have any obvious sensory or motor problems, the researchers believe that a closer look will reveal substantial deficits. (bio-medicine.org)
- Recently, an international team of researchers used several different types of MRI ( Magnetic Resonance Imaging) data to build a new and surprising map of the cerebral cortex. (forbes.com)
- In the new study, researchers took a different approach as they examined the activity in the cerebral cortex as a whole. (psychcentral.com)
- Researchers believe that each activity wave in the cerebral cortex is unique. (psychcentral.com)
Motor22
- Many areas of the cerebral cortex process sensory information or coordinate motor output necessary. (picsearch.com)
- The cerebral cortex has premotor and motor areas that control speech and writing. (picsearch.com)
- Nerve fibers from the motor areas join fibers leading to&from other areas of the cortex (the corona. (picsearch.com)
- The back of the cortex is predominantly specialized to process vision, whereas the front of the cortex handles motor functions and controls voluntary movement, as well as having a central role in higher cognitive functions. (bio-medicine.org)
- The cerebral cortex is divided into sensory, motor and association areas. (medicalartlibrary.com)
- Sensory areas receive sensory input, motor areas control movement of muscles. (medicalartlibrary.com)
- Broca's area , the motor speech area, is involved in translating thoughts into speech. (medicalartlibrary.com)
- By this method a region was demarcated, stimulation of portions of which evoked definite muscular movements, and the presence of a motor area was thus established. (humannervoussystem.info)
- in a crude manner motor and sensory areas may be thus delimited. (humannervoussystem.info)
- These cortical areas are involved in all aspects of skeletomotor control from response selection to motor preparation and movement execution. (scicombinator.com)
- JUST IN front of the motor area of the cerebral cortex of man there is a supplementary representation of movements. (jamanetwork.com)
- However, little is known about the development or ultimate organisation of cortical areas devoted to specific sensory and motor functions in these mice that may also contribute to their behavioural phenotype. (biomedcentral.com)
- We conducted two-photon calcium imaging of mouse layer 2/3 motor cortex during a self-initiated lever-pull task. (nii.ac.jp)
- Next, we conducted two-photon calcium imaging in the motor cortex during 14 training sessions of the self-initiated lever-pull task. (nii.ac.jp)
- The cerebral cortex is involved in many higher‐level functions such as sensory perception, cognition, language, memory, decision making, motor planning and control. (els.net)
- The remainder of the cortex is devoted to motor planning and control, as well as integration of multiple sensory cues and cognitive processing. (els.net)
- A homunculus is a little person represented in the motor (a) and somatosensory (b) cortex delineating the amount and location of cortical space devoted to sensing or moving the appropriate body part. (els.net)
- The representation is distorted such that areas that require fine motor control or that provide a lot of information about the sensory world (such as fingers) occupy a relatively larger cortical space. (els.net)
- Another surprising result of the research was that motor areas in the cerebral cortex, which are involved in the planning and performance of movement, provide a substantial input to the adrenal medulla. (kurzweilai.net)
- Damage to this area results in motor aphasia , in which patients can understand language but cannot produce meaningful or appropriate sounds. (howstuffworks.com)
- It is thought, for example, that the motor cortex does not have a layer 4, which suggests that the neural circuitry that controls movement differs from that in charge of vision, hearing, and other functions. (elifesciences.org)
- now challenge this view by providing multiple lines of evidence for the existence of layer 4 in the motor cortex in mice. (elifesciences.org)
Clinical1
- The Cerebral Cortex in Neurodegenerative and Neuropsychiatric Disorders: Experimental Approaches to Clinical Issues focuses on how pre-clinical investigations are addressing the clinical issues surrounding the involvement of the cerebral cortex in selected conditions of the nervous system, including Alzheimer's Disease, Parkinson's, addiction, and cardiovascular dysregulation. (elsevier.com)
Subdivision2
- ASSOCIATION AREAS OF THE CEREBRAL CORTEX The subdivision of the cerebral cortex into the. (picsearch.com)
- Names of connected areas are printed in the color of the subdivision it is connected to (dark green for LEC and light green for MEC) and the arrows indicate efferent/afferent connections with either the entire subdivision (same color) or preferentially with any of the different lateral-to-medial bands (arrows printed in the corresponding colors pink versus blue for lateral versus medial bands). (scholarpedia.org)
Localization2
- Thompson, Paul M, and Toga, Arthur W(Jul 2003) Cerebral Cortex Diseases and Cortical Localization. (els.net)
- Such systems do not exist physically, but they do serve as excellent mental grid-like tools (viewpoints) during localization and areas in which and from which relationships can be described. (chiro.org)
Localisation1
- Translated as: Localisation in the Cerebral Cortex, London: Smith‐Gordon, new edition 1999. (els.net)