###### Area Under Curve

A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)

###### ROC Curve

###### Sensitivity and Specificity

###### Dose-Response Relationship, Drug

###### Scoliosis

###### Reproducibility of Results

The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

###### Predictive Value of Tests

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

###### Maximal Expiratory Flow-Volume Curves

###### Models, Biological

###### Half-Life

###### Calibration

###### Algorithms

###### Mathematics

###### Transition Temperature

###### Drug Interactions

###### Prospective Studies

###### Biological Availability

###### Muscle Contraction

###### Models, Statistical

###### Retrospective Studies

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

###### Treatment Outcome

###### Metabolic Clearance Rate

###### Biological Markers

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

###### Cross-Over Studies

Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)

###### Hydrogen-Ion Concentration

###### Computer Simulation

###### Chromatography, High Pressure Liquid

###### Prognosis

###### Rabbits

###### Guinea Pigs

###### Reference Standards

###### Models, Theoretical

###### Thoracic Vertebrae

###### Membrane Potentials

The voltage differences across a membrane. For cellular membranes they are computed by subtracting the voltage measured outside the membrane from the voltage measured inside the membrane. They result from differences of inside versus outside concentration of potassium, sodium, chloride, and other ions across cells' or ORGANELLES membranes. For excitable cells, the resting membrane potentials range between -30 and -100 millivolts. Physical, chemical, or electrical stimuli can make a membrane potential more negative (hyperpolarization), or less negative (depolarization).

###### Regression Analysis

Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.

###### Temperature

###### Calcium

A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.

###### Analysis of Variance

###### Risk Assessment

###### Severity of Illness Index

###### Pressure

###### Follow-Up Studies

###### Data Interpretation, Statistical

###### Rats, Sprague-Dawley

###### Nucleic Acid Denaturation

Disruption of the secondary structure of nucleic acids by heat, extreme pH or chemical treatment. Double strand DNA is "melted" by dissociation of the non-covalent hydrogen bonds and hydrophobic interactions. Denatured DNA appears to be a single-stranded flexible structure. The effects of denaturation on RNA are similar though less pronounced and largely reversible.

###### Dose-Response Relationship, Radiation

###### Risk Factors

###### Action Potentials

###### Logistic Models

Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.

###### Electrophysiology

###### Image Interpretation, Computer-Assisted

###### Cohort Studies

Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.

###### Muscle, Smooth

Unstriated and unstriped muscle, one of the muscles of the internal organs, blood vessels, hair follicles, etc. Contractile elements are elongated, usually spindle-shaped cells with centrally located nuclei. Smooth muscle fibers are bound together into sheets or bundles by reticular fibers and frequently elastic nets are also abundant. (From Stedman, 25th ed)

###### Rats, Wistar

###### Linear Models

###### Age Factors

Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.

###### Infusions, Intravenous

###### Drug Administration Schedule

###### Pregnancy

###### Biomechanical Phenomena

###### Norepinephrine

Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.

###### Spinal Fusion

###### Models, Chemical

###### Cattle

###### Observer Variation

The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).

###### Kaplan-Meier Estimate

A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)

###### Case-Control Studies

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

###### Oxygen

###### Survival Analysis

A class of statistical procedures for estimating the survival function (function of time, starting with a population 100% well at a given time and providing the percentage of the population still well at later times). The survival analysis is then used for making inferences about the effects of treatments, prognostic factors, exposures, and other covariates on the function.

###### Radioimmunoassay

Classic quantitative assay for detection of antigen-antibody reactions using a radioactively labeled substance (radioligand) either directly or indirectly to measure the binding of the unlabeled substance to a specific antibody or other receptor system. Non-immunogenic substances (e.g., haptens) can be measured if coupled to larger carrier proteins (e.g., bovine gamma-globulin or human serum albumin) capable of inducing antibody formation.

###### Swine

Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).

###### Insulin

A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).

###### Lung Volume Measurements

###### Binding, Competitive

###### Models, Cardiovascular

###### Diagnosis, Computer-Assisted

###### Statistics as Topic

###### Lung Compliance

The capability of the LUNGS to distend under pressure as measured by pulmonary volume change per unit pressure change. While not a complete description of the pressure-volume properties of the lung, it is nevertheless useful in practice as a measure of the comparative stiffness of the lung. (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p562)

###### Microbial Sensitivity Tests

###### Tissue Distribution

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

###### Image Processing, Computer-Assisted

###### Radiopharmaceuticals

###### Phenylephrine

###### Body Weight

###### Indicator Dilution Techniques

###### Orthopedic Fixation Devices

###### Rats, Inbred Strains

###### Histamine

###### Liver

###### Lung

###### Isoproterenol

###### Tomography, X-Ray Computed

###### Statistics, Nonparametric

A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

###### Acetylcholine

###### Nephelometry and Turbidimetry

Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.

###### Glucose Tolerance Test

###### Sodium

###### Carbon Radioisotopes

###### Magnetic Resonance Imaging

###### Spectrophotometry, Ultraviolet

###### Double-Blind Method

###### Multivariate Analysis

###### Tumor Markers, Biological

Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.

###### Image Enhancement

###### Thermodynamics

A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)

###### Patch-Clamp Techniques

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.

###### Limit of Detection

###### Cats

The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)

###### Internal Fixators

###### Carbon Dioxide

###### Protein Binding

###### Neurons

###### Brain

The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.

###### Survival Rate

###### Nonlinear Dynamics

The study of systems which respond disproportionately (nonlinearly) to initial conditions or perturbing stimuli. Nonlinear systems may exhibit "chaos" which is classically characterized as sensitive dependence on initial conditions. Chaotic systems, while distinguished from more ordered periodic systems, are not random. When their behavior over time is appropriately displayed (in "phase space"), constraints are evident which are described by "strange attractors". Phase space representations of chaotic systems, or strange attractors, usually reveal fractal (FRACTALS) self-similarity across time scales. Natural, including biological, systems often display nonlinear dynamics and chaos.

###### Osmolar Concentration

###### Neural Networks (Computer)

A computer architecture, implementable in either hardware or software, modeled after biological neural networks. Like the biological system in which the processing capability is a result of the interconnection strengths between arrays of nonlinear processing nodes, computerized neural networks, often called perceptrons or multilayer connectionist models, consist of neuron-like units. A homogeneous group of units makes up a layer. These networks are good at pattern recognition. They are adaptive, performing tasks by example, and thus are better for decision-making than are linear learning machines or cluster analysis. They do not require explicit programming.

###### Models, Neurological

###### Water

###### Vasoconstriction

###### Polymerase Chain Reaction

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

###### Proportional Hazards Models

###### Least-Squares Analysis

###### Positron-Emission Tomography

An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.

###### Hemoglobins

###### Biometry

###### Kyphosis

###### Kidney

###### Immunoassay

###### Airway Resistance

###### Braces

###### Myocardium

###### Binding Sites

###### Adrenergic alpha-Antagonists

###### Anti-Infective Agents

###### Iodine Radioisotopes

###### Ion Channels

###### Carbachol

###### Aging

###### Absorption

###### Software

###### Discriminant Analysis

###### Ion Channel Gating

The opening and closing of ion channels due to a stimulus. The stimulus can be a change in membrane potential (voltage-gated), drugs or chemical transmitters (ligand-gated), or a mechanical deformation. Gating is thought to involve conformational changes of the ion channel which alters selective permeability.

###### Dye Dilution Technique

###### Blood Flow Velocity

###### Feasibility Studies

###### Monte Carlo Method

In statistics, a technique for numerically approximating the solution of a mathematical problem by studying the distribution of some random variable, often generated by a computer. The name alludes to the randomness characteristic of the games of chance played at the gambling casinos in Monte Carlo. (From Random House Unabridged Dictionary, 2d ed, 1993)

###### Radioisotope Dilution Technique

###### Magnesium

###### Neoplasms

###### Imaging, Three-Dimensional

The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.

###### Trachea

###### Sodium Channels

###### Epidemiologic Methods

###### Radioligand Assay

###### Cells, Cultured

###### Respiratory Mechanics

###### Enzyme-Linked Immunosorbent Assay

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

###### Adenosine Triphosphate

###### Calcium Channel Blockers

###### Stress, Mechanical

###### Radiographic Image Interpretation, Computer-Assisted

###### Clinical Competence

###### False Positive Reactions

###### Parasympatholytics

###### Species Specificity

The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.

## In vivo modulation of alternative pathways of P-450-catalyzed cyclophosphamide metabolism: impact on pharmacokinetics and antitumor activity. (1/6505)

The widely used anticancer prodrug cyclophosphamide (CPA) is activated in liver by a 4-hydroxylation reaction primarily catalyzed by cytochrome P-4502B and P-4502C enzymes. An alternative metabolic pathway involves CPA N-dechloroethylation to yield chloroacetaldehyde (CA), a P-4503A-catalyzed deactivation/neurotoxication reaction. The in vivo modulation of these alternative, competing pathways of P-450 metabolism was investigated in pharmacokinetic studies carried out in the rat model. Peak plasma concentrations (Cmax) for 4-OH-CPA and CA were increased by 3- to 4-fold, and apparent plasma half-lives of both metabolites were correspondingly shortened in rats pretreated with phenobarbital (PB), an inducer of P-4502B and P-4503A enzymes. However, PB had no net impact on the extent of drug activation or its partitioning between these alternative metabolic pathways, as judged from AUC values (area-under-the-plasma concentration x time curve) for 4-OH-CPA and CA. The P-4503A inhibitor troleandomycin (TAO) decreased plasma Cmax and AUC of CA (80-85% decrease) without changing the Cmax or AUC of 4-OH-CPA in uninduced rats. In PB-induced rats, TAO decreased AUCCA by 73%, whereas it increased AUC4-OH-CPA by 93%. TAO thus selectively suppresses CPA N-dechloroethylation, thereby increasing the availability of drug for P-450 activation via 4-hydroxylation. By contrast, dexamethasone, a P-4503A inducer and antiemetic widely used in patients with cancer, stimulated large, undesirable increases in the Cmax and AUC of CA (8- and 4-fold, respectively) while reducing the AUC of the 4-hydroxylation pathway by approximately 60%. Tumor excision/in vitro colony formation and tumor growth delay assays using an in vivo 9L gliosarcoma solid tumor model revealed that TAO suppression of CPA N-dechloroethylation could be achieved without compromising the antitumor effect of CPA. The combination of PB with TAO did not, however, enhance the antitumor activity of CPA, despite the approximately 2-fold increase in AUC4-OH-CPA, suggesting that other PB-inducible activities, such as aldehyde dehydrogenase, may counter this increase through enhanced deactivation of the 4-hydroxy metabolite. Together, these studies demonstrate that the P-4503A inhibitor TAO can be used to effectively modulate CPA metabolism and pharmacokinetics in vivo in a manner that decreases the formation of toxic metabolites that do not contribute to antitumor activity. (+info)## Prediction of the effects of inoculum size on the antimicrobial action of trovafloxacin and ciprofloxacin against Staphylococcus aureus and Escherichia coli in an in vitro dynamic model. (2/6505)

The effect of inoculum size (N0) on antimicrobial action has not been extensively studied in in vitro dynamic models. To investigate this effect and its predictability, killing and regrowth kinetics of Staphylococcus aureus and Escherichia coli exposed to monoexponentially decreasing concentrations of trovafloxacin (as a single dose) and ciprofloxacin (two doses at a 12-h interval) were compared at N0 = 10(6) and 10(9) CFU/ml (S. aureus) and at N0 = 10(6), 10(7), and 10(9) CFU/ml (E. coli). A series of pharmacokinetic profiles of trovafloxacin and ciprofloxacin with respective half-lives of 9.2 and 4 h were simulated at different ratios of area under the concentration-time curve (AUC) to MIC (in [micrograms x hours/milliliter]/[micrograms/milliliter]): 58 to 466 with trovafloxacin and 116 to 932 with ciprofloxacin for S. aureus and 58 to 233 and 116 to 466 for E. coli, respectively. Although the effect of N0 was more pronounced for E. coli than for S. aureus, only a minor increase in minimum numbers of surviving bacteria and an almost negligible delay in their regrowth were associated with an increase of the N0 for both organisms. The N0-induced reductions of the intensity of the antimicrobial effect (IE, area between control growth and the killing-regrowth curves) were also relatively small. However, the N0 effect could not be eliminated either by simple shifting of the time-kill curves obtained at higher N0s by the difference between the higher and lowest N0 or by operating with IEs determined within the N0-adopted upper limits of bacterial numbers (IE's). By using multivariate correlation and regression analyses, linear relationships between IE and log AUC/MIC and log N0 related to the respective mean values [(log AUC/MIC)average and (log N0)average] were established for both trovafloxacin and ciprofloxacin against each of the strains (r2 = 0.97 to 0.99). The antimicrobial effect may be accurately predicted at a given AUC/MIC of trovafloxacin or ciprofloxacin and at a given N0 based on the relationship IE = a + b [(log AUC/MIC)/(log AUC/MIC)average] - c [(log N0)/(log N0)average]. Moreover, the relative impacts of AUC/MIC and N0 on IE may be evaluated. Since the c/b ratios for trovafloxacin and ciprofloxacin against E. coli were much lower (0.3 to 0.4) than that for ampicillin-sulbactam as examined previously (1.9), the inoculum effect with the quinolones may be much less pronounced than with the beta-lactams. The described approach to the analysis of the inoculum effect in in vitro dynamic models might be useful in studies with other antibiotic classes. (+info)## Pharmacokinetics and urinary excretion of amikacin in low-clearance unilamellar liposomes after a single or repeated intravenous administration in the rhesus monkey. (3/6505)

Liposomal aminoglycosides have been shown to have activity against intracellular infections, such as those caused by Mycobacterium avium. Amikacin in small, low-clearance liposomes (MiKasome) also has curative and prophylactic efficacies against Pseudomonas aeruginosa and Klebsiella pneumoniae. To develop appropriate dosing regimens for low-clearance liposomal amikacin, we studied the pharmacokinetics of liposomal amikacin in plasma, the level of exposure of plasma to free amikacin, and urinary excretion of amikacin after the administration of single-dose (20 mg/kg of body weight) and repeated-dose (20 mg/kg eight times at 48-h intervals) regimens in rhesus monkeys. The clearance of liposomal amikacin (single-dose regimen, 0.023 +/- 0.003 ml min-1 kg-1; repeated-dose regimen, 0.014 +/- 0.001 ml min-1 kg-1) was over 100-fold lower than the creatinine clearance (an estimate of conventional amikacin clearance). Half-lives in plasma were longer than those reported for other amikacin formulations and declined during the elimination phase following administration of the last dose (from 81.7 +/- 27 to 30.5 +/- 5 h). Peak and trough (48 h) levels after repeated dosing reached 728 +/- 72 and 418 +/- 60 micrograms/ml, respectively. The levels in plasma remained > 180 micrograms/ml for 6 days after the administration of the last dose. The free amikacin concentration in plasma never exceeded 17.4 +/- 1 micrograms/ml and fell rapidly (half-life, 1.47 to 1.85 h) after the administration of each dose of liposomal amikacin. This and the low volume of distribution (45 ml/kg) indicate that the amikacin in plasma largely remained sequestered in long-circulating liposomes. Less than half the amikacin was recovered in the urine, suggesting that the level of renal exposure to filtered free amikacin was reduced, possibly as a result of intracellular uptake or the metabolism of liposomal amikacin. Thus, low-clearance liposomal amikacin could be administered at prolonged (2- to 7-day) intervals to achieve high levels of exposure to liposomal amikacin with minimal exposure to free amikacin. (+info)## Influences of urinary pH on ciprofloxacin pharmacokinetics in humans and antimicrobial activity in vitro versus those of sparfloxacin. (4/6505)

The impact of acidification and alkalinization of urine on the pharmacokinetics of ciprofloxacin was investigated after single 200-mg oral doses were administered to nine healthy male volunteers. In addition, the effect of human urine on the MICs of ciprofloxacin and sparfloxacin against some common urinary tract pathogens such as Escherichia coli and Pseudomonas aeruginosa was investigated. Acidic and alkaline conditions were achieved by repeated oral doses of ammonium chloride or sodium bicarbonate, respectively. Plasma ciprofloxacin levels in all subjects were adequately described in terms of two-compartment model kinetics with first-order absorption. Acidification and alkalinization treatments had no effect on ciprofloxacin absorption, distribution, or elimination. The total amount of unchanged ciprofloxacin excreted over 24 h under acidic conditions was 88.4 +/- 14.5 mg (mean +/- standard deviation) (44.2% of the oral dose) and 82.4 +/- 16.5 mg (41.2% of the oral dose) under alkaline conditions, while the total amount of unchanged drug excreted over 24 h in volunteers receiving neither sodium bicarbonate nor ammonium chloride was 90.53 +/- 9.8 mg (45.2% of the oral dose). The mean renal clearance of ciprofloxacin was 16.78 +/- 2.67, 16.08 +/- 3.2, and 16.31 +/- 2.67 liters/h with acidification, alkalinization, and control, respectively. Renal clearance and concentrations of ciprofloxacin in urine were not correlated with urinary pH. The antibacterial activity of ciprofloxacin and sparfloxacin against E. coli NIHJ JC-2 and P. aeruginosa ATCC 27853 was affected by human urine and in particular by its pH. The activities of both quinolones against E. coli NIHJ JC-2 were lower at lower urinary pH and rather uniform, while in the case of P. aeruginosa ATCC 27853 ciprofloxacin was more active than sparfloxacin. (+info)## Pharmacokinetics of ethambutol under fasting conditions, with food, and with antacids. (5/6505)

Ethambutol (EMB) is the most frequent "fourth drug" used for the empiric treatment of Mycobacterium tuberculosis and a frequently used drug for infections caused by Mycobacterium avium complex. The pharmacokinetics of EMB in serum were studied with 14 healthy males and females in a randomized, four-period crossover study. Subjects ingested single doses of EMB of 25 mg/kg of body weight under fasting conditions twice, with a high-fat meal, and with aluminum-magnesium antacid. Serum was collected for 48 h and assayed by gas chromatography-mass spectrometry. Data were analyzed by noncompartmental methods and by a two-compartment pharmacokinetic model with zero-order absorption and first-order elimination. Both fasting conditions produced similar results: a mean (+/- standard deviation) EMB maximum concentration of drug in serum (Cmax) of 4.5 +/- 1.0 micrograms/ml, time to maximum concentration of drug in serum (Tmax) of 2.5 +/- 0.9 h, and area under the concentration-time curve from 0 h to infinity (AUC0-infinity) of 28.9 +/- 4.7 micrograms.h/ml. In the presence of antacids, subjects had a mean Cmax of 3.3 +/- 0.5 micrograms/ml, Tmax of 2.9 +/- 1.2 h, and AUC0-infinity of 27.5 +/- 5.9 micrograms.h/ml. In the presence of the Food and Drug Administration high-fat meal, subjects had a mean Cmax of 3.8 +/- 0.8 micrograms/ml, Tmax of 3.2 +/- 1.3 h, and AUC0-infinity of 29.6 +/- 4.7 micrograms.h/ml. These reductions in Cmax, delays in Tmax, and modest reductions in AUC0-infinity can be avoided by giving EMB on an empty stomach whenever possible. (+info)## Safety and pharmacokinetics of abacavir (1592U89) following oral administration of escalating single doses in human immunodeficiency virus type 1-infected adults. (6/6505)

Abacavir (1592U89) is a nucleoside analog reverse transcriptase inhibitor that has been demonstrated to have selective activity against human immunodeficiency virus (HIV) in vitro and favorable safety profiles in mice and monkeys. A phase I study was conducted to evaluate the safety and pharmacokinetics of abacavir following oral administration of single escalating doses (100, 300, 600, 900, and 1,200 mg) to HIV-infected adults. In this double-blind, placebo-controlled study, subjects with baseline CD4+ cell counts ranging from < 50 to 713 cells per mm3 (median, 315 cells per mm3) were randomly assigned to receive abacavir (n = 12) or placebo (n = 6). The bioavailability of the caplet formulation relative to that of the oral solution was also assessed with the 300-mg dose. Abacavir was well tolerated by all subjects; mild to moderate asthenia, abdominal pain, headache, diarrhea, and dyspepsia were the most frequently reported adverse events, and these were not dose related. No significant clinical or laboratory abnormalities were observed throughout the study. All doses resulted in mean abacavir concentrations in plasma that exceeded the mean 50% inhibitory concentration (IC50) for clinical HIV isolates in vitro (0.07 microgram/ml) for almost 3 h. Abacavir was rapidly absorbed following oral administration, with the time to the peak concentration in plasma occurring at 1.0 to 1.7 h postdosing. Mean maximum concentrations in plasma (Cmax) and the area under the plasma concentration-time curve from time zero to infinity (AUC0-infinity) increased slightly more than proportionally from 100 to 600 mg (from 0.6 to 4.7 micrograms/ml for Cmax; from 1.0 to 15.7 micrograms.h/ml for AUC0-infinity) but increased proportionally from 600 to 1,200 mg (from 4.7 to 9.6 micrograms/ml for Cmax; from 15.7 to 32.8 micrograms.h/ml for AUC0-infinity. The elimination of abacavir from plasma was rapid, with an apparent elimination half-life of 0.9 to 1.7 h. Abacavir was well absorbed, with a relative bioavailability of the caplet formulation of 96% versus that of an oral solution (drug substance in water). In conclusion, this study showed that abacavir is safe and is well tolerated by HIV-infected subjects and demonstrated predictable pharmacokinetic characteristics when it was administered as single oral doses ranging from 100 to 1,200 mg. (+info)## Safety and single-dose pharmacokinetics of abacavir (1592U89) in human immunodeficiency virus type 1-infected children. (7/6505)

Abacavir (formerly 1592U89) is a potent 2'-deoxyguanosine analog reverse transcriptase inhibitor that has been demonstrated to have a favorable safety profile in initial clinical trials with adults with human immunodeficiency virus (HIV) type 1 infection. A phase I study was conducted to evaluate the pharmacokinetics and safety of abacavir following the administration of two single oral doses (4 and 8 mg/kg of body weight) to 22 HIV-infected children ages 3 months to 13 years. Plasma was collected for analysis at predose and at 0.5, 1, 1.5, 2, 2.5, 3, 5, and 8 h after the administration of each dose. Plasma abacavir concentrations were determined by high-performance liquid chromatography, and data were analyzed by noncompartmental methods. Abacavir was well tolerated by all subjects. The single abacavir-related adverse event was rash, which occurred in 2 of 22 subjects. After administration of the oral solution, abacavir was rapidly absorbed, with the time to the peak concentration in plasma occurring within 1.5 h postdosing. Pharmacokinetic parameter estimates were comparable among the different age groups for each dose level. The mean maximum concentration in plasma (Cmax) and the mean area under the curve from time zero to infinity (AUC0-infinity) increased by 16 and 45% more than predicted, respectively, as the abacavir dose was doubled from 4 to 8 mg/kg (Cmax increased from 1.69 to 3.94 micrograms/ml, and AUC0-infinity increased from 2.82 to 8.09 micrograms.h/ml). Abacavir was rapidly eliminated, with a mean elimination half-life of 0.98 to 1.13 h. The mean apparent clearance from plasma decreased from 27.35 to 18.88 ml/min/kg as the dose increased. Neither body surface area nor creatinine clearance were correlated with pharmacokinetic estimates at either dose. The extent of exposure to abacavir appears to be slightly lower in children than in adults, with the comparable unit doses being based on body weight. In conclusion, this study showed that abacavir is safe and well tolerated in children when it is administered as a single oral dose of 4 or 8 mg/kg. (+info)## Optimizing aminoglycoside therapy for nosocomial pneumonia caused by gram-negative bacteria. (8/6505)

Nosocomial pneumonia is a notable cause of morbidity and mortality and leads to increases in lengths of hospital stays and institutional expenditures. Aminoglycosides are used to treat patients with these infections, but few data on the doses and schedules required to achieve optimal therapeutic outcomes exist. We analyzed aminoglycoside treatment data for 78 patients with nosocomial pneumonia to determine if optimization of aminoglycoside pharmacodynamic parameters results in a more rapid therapeutic response (defined by outcome and days to leukocyte count resolution and temperature resolution). Cox proportional hazards, Classification and Regression Tree (CART), and logistic regression analyses were applied to the data. By all analyses, the first measured maximum concentration of drug in serum (Cmax)/MIC predicted days to temperature resolution and the second measured Cmax/MIC predicted days to leukocyte count resolution. For days to temperature resolution and leukocyte count resolution, CART analyses produced breakpoints, with an 89% success rate at 7 days of therapy for a Cmax/MIC of > 4.7 and an 86% success rate at 7 days of therapy for a Cmax/MIC of > 4.5, respectively. Logistic regression analyses predicted a 90% probability of temperature resolution and leukocyte count resolution by day 7 if a Cmax/MIC of > or = 10 is achieved within the first 48 h of aminoglycoside therapy. Aggressive aminoglycoside dosing immediately followed by individualized pharmacokinetic monitoring would ensure that Cmax/MIC targets are achieved early in therapy. This would increase the probability of a rapid therapeutic response for pneumonia caused by gram-negative bacteria and potentially decreasing durations of parenteral antibiotic therapy, lengths of hospitalization, and institutional expenditures, a situation in which both the patient and the institution benefit. (+info)###### Trapezoidal distribution - Wikipedia

###### A Study to Assess Safety, Tolerability and Pharmacokinetics of Ceftaroline in Healthy Subjects - Tabular View - ClinicalTrials...

###### Impact of the blood sampling site on time-concentration drug profiles following intravenous or buccal drug administration<...

###### A phase 1 study investigating pharmacokinetic and pharmacodynamic relationships of CPX-351 (Vyxeos,a novel formulation of...

###### Patent US3881495 - Method of nerve therapy using trapezoidal pulses - Google Patents

###### Comparison of Plasma and Intrapulmonary Concentrations of Nafithromycin (WCK 4873) in Healthy Adult Subjects | Antimicrobial...

###### Search of: Subependymal giant cell astrocytoma - List Results - ClinicalTrials.gov

###### Trapezoidal Commutation Mode - Automatic Sensor Setup fails + Rotation backward - Roboteq Online Forum

###### German Trapezoidal Violin Flight Case, Gewa, c. 1970 Auction Number 3490T Lot Number 1006 | Skinner Auctioneers

###### Spear Trapezoidal Flip Top Tables | Stylish Office Furniture : Great Deals, Low Prices!

###### Mathematics of Computation

###### Mecophilus neotropicus Silvestri 1909 - Plazi TreatmentBank

###### Plus it

###### Nonlinear Pharmacokinetics of Efavirenz (DMP-266), a Potent HIV-1 Reverse Transcriptase Inhibitor, in Rats and Monkeys | Drug...

###### DailyMed - RYDAPT capsule, liquid filled

###### Plus it

###### ConcentrationandSolubility - Concentration vs Solubility From http/www.iit.edu/~smile Therese Donatello 7929 Elm Grove Dr...

###### A Trapezoidal, Slat Crystal PET Detector for Multimodality PET Imaging - Robert Miyaoka

###### Phase 1, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose, Safety, Tolerability and Pharmacokinetics Study...

###### PPT - Definite Integrals PowerPoint Presentation, free download - ID:6242366

###### Plus it

###### Issue July - September-2020 | Pharmacokinetics & Pharmacodynamics ...

###### Infinity Means - 28 images - Infinity Vignette Huffpost, The World S Catalog Of Ideas, Infinity Symbol Meaning Factory Direct...

###### group schemes - Kernel of powers of Frobenius on supersingular elliptic curves - MathOverflow

###### Numerical Integration

###### Son Evan (12 MONTHS)

###### State of Synthetix H2 2020

###### A Journey into Quilling & Paper Crafting: Quilling Tutorial New Technique - Graphic quilling monograms, quilling letters,...

###### Suppliers News

###### After effects roto brush calculate forward

###### OSA | Tolerant polarization converter for InGaAsP-InP photonic integrated circuits

###### Biochemistry, Pharmacokinetics, and Pharmacodynamics

###### Biochemistry, Pharmacokinetics, and Pharmacodynamics

###### Wallhogs Teed Up Wall Mural; 16 H x 24 W | Staples

###### Assessment of oral midazolam limited sampling strategies to predict area under the concentration time curve (AUC) during...

###### Pharmacokinetic Modeling and Limited Sampling Strategies Based on Healthy Volunteers for Monitoring of Ertapenem in Patients...

###### July | 2017 | jak-inhibitors

###### Pharmacokinetics-pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients |...

###### Which Dose of Busulfan Is Best | AACC.org

###### Background: Area under the concentration-time curve (AUC) is a pharmacokinetic parameter - Drug Resistance to EGFR Inhibitors...

###### Safety, pharmacokinetics, and antitumor properties of anlotinib, an oral multi-target tyrosine kinase inhibitor, in patients...

###### Repository at Hanyang University: The effect of coenzyme Q10 on the pharmacokinetic parameters of theophylline

###### Importance of first-pass elimination for interindividual differences in steady-state concentrations of the adrenergicβ...

###### A Randomized Study of Pharmacokinetics, Efficacy, and Safety of 2 Raltegravir Plus Atazanavir Strategies in ART-Treated Adults

###### AID 236679 - Maximum plasma concentration in rat after oral administration at 10 mg/kg dosage - PubChem

###### Publications

###### Role of Pharmacokinetics and Pharmacodynamics: Does the Dose Matter? : Clinical Infectious Diseases - oi

###### Most recent papers with the keyword Children and pharmacokinetics | Read by QxMD

###### These highlights do not include all the information needed to use Azithromycin safely and effectively. See full prescribing...

###### June | 2017 | mirna mimics

###### Cardiovascular Efficacy and Models

###### Bias in Estimating Multivariate and Univariate Diffusions

###### t130x reinforced ultrafine mill ball mill high frequency screen

###### Molecules | Free Full-Text | Pharmacokinetic Study in Mice of Galphimine-A, an Anxiolytic Compound from Galphimia glauca | HTML

###### Use Simpsons Rule with n = 10 to estimate the arc length of the curve

###### Pharmacokinetics of multiple-dose administration of eltenac in horses

###### Trajectory Optimization: New in Wolfram Language 12

###### Clinical Trials Register

###### A Pharmacokinetics Study to Investigate the Effect of Vemurafenib on Digoxin in Patients With BRAFV600 Mutation-Positive...

###### Overcoming the Resistance Hurdle: Pharmacokinetic-Pharmacodynamic Target Attainment Analyses for Rezafungin (CD101) against...

###### pr.probability - Problem on convergence in probability measres - MathOverflow

**Area** under the **curve** (pharmacokinetics)

In the field of pharmacokinetics, the

**area**under the**curve**(AUC) is the definite integral of the concentration of a drug in ... "**Area**Under**Curve**" of the Receiver operating characteristic Maurer, Hans H. (2005). "Multi-analyte procedures for screening for ...###### Partial **Area** Under the ROC **Curve**

To overcome this limitation of AUC, it was proposed to compute the

**area**under the ROC**curve**in the**area**of the ROC space that ... over**area**\ of\ the\ RoI}} RRA=1 indicates perfect accuracy, while RRA=0 indicates that the**area**under the ROC**curve**belonging ... the ROC**curve**of C a {\displaystyle C_{a}} is never above the ROC**curve**of C b {\displaystyle C_{b}} the ROC**curve**of C a {\ ... The Partial**Area**Under the ROC**Curve**(pAUC) is a metric for the performance of binary classifier. It is computed based on the ...**Curve** (magazine)

**Curve**. October 15, 2010. Cassell, Heather (October 20, 2010). "Publisher sells SF-based

**Curve**magazine". Bay

**Area**Reporter. ... "A

**Curve**in the Road for

**Curve**Magazine". GO. Retrieved 22 January 2019. "

**Curve**Facts".

**Curve**Magazine. 2019. Archived from the ...

**Curve**wrote about cybersex in 1995. In 2003,

**Curve**was early in reporting on pregnancies within the queer community.

**Curve**had ... Ahead of the

**Curve**was released in theaters, digital platforms and DVD on June 1, 2021. In a 2000 interview with

**Curve**, Sinead ...

**Curve**

For example, the image of a simple

**curve**can cover a square in the plane (space-filling**curve**) and thus have a positive**area**. ... Coordinate**curve**Crinkled arc**Curve**fitting**Curve**orientation**Curve**sketching Differential geometry of**curves**Gallery of**curves**... A space**curve**is a**curve**for which X {\displaystyle X} is at least three-dimensional; a skew**curve**is a space**curve**which lies ... and the**curve**is a parametric**curve**. In this article, these**curves**are sometimes called topological**curves**to distinguish them ...###### Parallel **curve**

... is not true in the

**area**of interest. The involutes of a given**curve**are a set of parallel**curves**. For example: the involutes of ... In this case, one gets a parallel**curve**on the opposite side of the**curve**(see diagram on the parallel**curves**of a circle). One ... using a sine**curve**as progenitor**curve**. In general, even if a**curve**is rational, its offsets may not be so. For example, the ... offsets an algebraic**curve**of degree 8. A Bézier**curve**of degree n has as (two-sided) offsets algebraic**curves**of degree 4n − 2 ...###### Gotham **Curve**

The sparsely populated, largely agricultural

**area**surrounding the**curve**meant that coal was the only significant inflow and ... The Gotham**Curve**was once the sharpest**curve**on any standard gauge railway line in the UK. The**curve**, which was situated in the ... the line through the Gotham**curve**went through an 80 degree**curve**with a radius of 55 yards (50 m). The**curve**was subject to a ... Horseshoe**Curve**(Pennsylvania) - a historic three-track railroad**curve**on the Norfolk Southern Railway in Pennsylvania, United ...###### Stress-strain **curve**

... while the

**curve**based on the instantaneous cross-section**area**and length is called the true stress-strain**curve**. Unless stated ... This is not true since the actual**area**will decrease while deforming due to elastic and plastic deformation. The**curve**based on ... it is the maximal point in engineering stress-strain**curve**but is not a special point in true stress-strain**curve**. Because ... The material is experiencing a stress defined to be the ratio of the force to the cross sectional**area**of the bar, as well as ...###### Fish **curve**

The

**area**of a fish**curve**is given by: A = 1 2 , ∫ ( x y ′ − y x ′ ) d t , {\displaystyle A={\frac {1}{2}}\left,\int {\left(xy'- ... A fish**curve**is an ellipse negative pedal**curve**that is shaped like a fish. In a fish**curve**, the pedal point is at the focus ... Weisstein, Eric W. "Fish**Curve**". MathWorld. Retrieved May 23, 2010. Lockwood, E. H. (1967). A Book of**Curves**. Cambridge, ... giving the overall**area**for the fish as: A = 4 3 a 2 {\displaystyle A={\frac {4}{3}}a^{2}} . The arc length of the**curve**is ...###### Species discovery **curve**

... the species-

**area****curve**. The species discovery**curve**will necessarily be increasing, and will normally be negatively accelerated ... In ecology, the species discovery**curve**(also known as a species accumulation**curve**or collector's**curve**) is a graph recording ... This is usually done by fitting some kind of functional form to the**curve**, either by eye or by using non-linear regression ... However, some theoretical approaches imply that the logarithmic**curve**may be more appropriate,[citation needed] implying that ...###### Family of **curves**

Families of

**curves**may also arise in other**areas**. For example, all non-degenerate conic sections can be represented using a ... Sets of**curves**given by an implicit relation may also represent families of**curves**. Families of**curves**appear frequently in ... Families of**curves**may arise in various topics in geometry, including the envelope of a set of**curves**and the caustic of a ... In geometry, a family of**curves**is a set of**curves**, each of which is given by a function or parametrization in which one or ...###### Growth **curve** (biology)

Cancer research is an

**area**of biology where growth**curve**analysis plays an important role. In many types of cancer, the rate at ... Gompertz function Exponential**curve**(J-**curve**) Logistic**curve**(sigmoid**curve**, S-**curve**) Von Bertalanffy function Kaneshiro, Neil ... A growth**curve**is an empirical model of the evolution of a quantity over time. Growth**curves**are widely used in biology for ... Analysis of the molecular basis for this bi-phasic growth**curve**led to the discovery of the basic mechanisms that control gene ...###### Abbott-Firestone **curve**

The Abbott-Firestone

**curve**or bearing**area****curve**(BAC) describes the surface texture of an object. The**curve**can be found from ... The Abbott-Firestone**curve**was first described by Ernest James Abbott and Floyd Firestone in 1933. It is useful for ... The shape of the**curve**is distilled into several of the surface roughness parameters, especially the Rk family of parameters. ...###### Elliptic **curve**

Elliptic

**curves**are especially important in number theory, and constitute a major**area**of current research; for example, they ... Hessian**curve**Edwards**curve**Twisted**curve**Twisted Hessian**curve**Twisted Edwards**curve**Doubling-oriented Doche-Icart-Kohel**curve**... Wikiquote has quotations related to Elliptic**curve**. LMFDB: Database of Elliptic**Curves**over Q "Elliptic**curve**", Encyclopedia of ... Elliptic**curve**cryptography Elliptic-**curve**Diffie-Hellman key exchange Supersingular isogeny key exchange Elliptic**curve**...###### Osgood **curve**

... an Osgood

**curve**is a non-self-intersecting**curve**that has positive**area**. Despite its**area**, it is not possible for such a**curve**... Osgood**curves**are named after William Fogg Osgood. A**curve**in the Euclidean plane is defined to be an Osgood**curve**when it is ... Osgood**curves**have Hausdorff dimension two, like space-filling**curves**. However, they cannot be space-filling**curves**: by Netto's ... but zero**area**in other parts; this flaw was corrected by Knopp (1917), who found a**curve**that has positive**area**in every ...###### Chrissy Gephardt

... according to

**Curve**. Gephardt was also featured on a cover of**Curve**in 2007. Swarns, Rachel L. (November 1, 2003). "Daughter ... "A queer look at Sundance". The Bay**Area**Reporter / B.A.R. Inc. Retrieved August 7, 2021. Stevens, Frances (November 2007). " ... I think we may have mastered the "do what you love and money will follow" credo".**Curve**. Archived from the original on July 29 ...**Curve**. Archived from the original on October 6, 2018. Retrieved May 16, 2017 - via HighBeam Research. Shesgreen, Deidre. " ...###### Breakthrough **curve**

Integration of the

**area**above the entire breakthrough**curve**gives the maximum loading of the adsorptive material. Additionally ... A breakthrough**curve**in adsorption is the course of the effluent adsorptive concentration at the outlet of a fixed bed adsorber ... The determination of breakthrough**curves**is the foundation of many other processes, like the pressure swing adsorption. Within ... The shape of the breakthrough**curves**contains information about the mass transfer properties of the adsorptive-adsorbent system ...###### Implicit **curve**

R1) Generate a net of points (raster) on the

**area**of interest of the x-y-plane. (R2) For every point P {\displaystyle P} in the ... To visualize an implicit**curve**one usually determines a polygon on the**curve**and displays the polygon. For a parametric**curve**... Within mathematics implicit**curves**play a prominent role as algebraic**curves**. In addition, implicit**curves**are used for ... determination of a first**curve**point to a given starting point in the vicinity of the**curve**, determination of a**curve**point ...###### Schuylkill Expressway

The Schuylkill Expressway

**curves**southeast near wooded**areas**of homes before coming to an interchange with PA 320 in the ... "Conshohocken**Curve**". WPVI. Retrieved 2009-08-09. "Rain Closes expressway east of Conshohocken**Curve**". The Philadelphia Inquirer ... "Conshohocken**Curve**" or "Conshy**Curve**", which has a history of traffic congestion and dangerous conditions. I-76 continues ... The freeway**curves**to the southwest, with CSX's Trenton Subdivision heading east away from the road and CSX's Harrisburg ...###### Hypsometry

The

**curve**can also be shown in non-dimensional or standardized form by scaling elevation and**area**by the maximum values. The ... Hypsometric**curves**are commonly used in limnology to represent the relationship between lake surface**area**and depth and ... When drawn as a 2-dimensional histogram, a hypsometric**curve**displays the elevation (y) on the vertical, y-axis and**area**above ... A hypsometric**curve**is a histogram or cumulative distribution function of elevations in a geographical**area**. Differences in ...###### Jump (Van Halen song)

NBC Sports Bay

**Area**Staff (October 6, 2020). "Nine best Van Halen sports anthems ranked, in Eddie's memory". NBCSports.com. ... "Winnipeg Jets pick Jump by Van Halen as new goal song". Illegal**Curve**. Archived from the original on December 20, 2016. ...###### San Francisco Drag King Contest

The contestants main requirement is that they come from the Bay

**Area**, otherwise the organizer notes "we have gay women who ... Messman-Rucker, Ariel (2008). "Drag Kings in the City".**Curve**Magazine. Retrieved 27 July 2012. "Wrestler wins drag king crown ... "New drag king crowned". Bay**Area**Reporter. August 23, 2007. Retrieved 27 July 2012. ... ". Bay**Area**Reporter. August 20, 2009. Retrieved 27 July 2012. Chun, Kimberly (August 11, 2011). "S.F. Drag King Contest a ...###### Greater Toronto English

"Cultural Exchange and the Transformation of Jamaican Patois in the Greater Toronto

**Area**" (PDF).**Curve**Carleton.{{cite web}}: ... In MLE, however, the (s) is not used except to refer to a group of guys.[citation needed] "6ix" (slang term for both the**area**... It is spoken specifically within the Greater Toronto**Area**and inner-city Toronto, generally by young, working-class people, in ...**area**, or neighbourhood)[citation needed] "Fam" (short for "family" but generally used to refer to a "friend") "Gyal" (girl) " ...###### Chav

"Cultural Exchange and the Transformation of Jamaican Patois in the Greater Toronto

**Area**" (PDF).**Curve**Carleton. Alozzi, Raneem ...###### Runoff **curve** number

The runoff

**curve**number is based on the**area's**hydrologic soil group, land use, treatment and hydrologic condition. References ... The lower the**curve**number, the more permeable the soil is. As can be seen in the**curve**number equation, runoff cannot begin ... The runoff**curve**number (also called a**curve**number or simply CN) is an empirical parameter used in hydrology for predicting ... Discharge and Runoff Calculator**Curve**Number Calculator Online Free**Curve**Number Calculator Introduction to SCS Runoff**Curve**...###### Cubic plane **curve**

The 1st equal

**areas**cubic is the locus of a point X such that**area**of the cevian triangle of X equals the**area**of the cevian ... Cayley-Bacharach theorem, on the intersection of two cubic plane**curves**Twisted cubic, a cubic space**curve**Elliptic**curve**Witch ... The 2nd equal**areas**cubic is the locus of X such that the**area**of the cevian triangle of XY equals the**area**of the cevian ... A non-singular plane cubic defines an elliptic**curve**, over any field K for which it has a point defined. Elliptic**curves**are ...**Curve**-billed reedhaunter

It is found in marshy

**areas**of north-eastern Argentina, south-eastern Brazil, and Uruguay. It occupies a similar ecological ... The**curve**-billed reedhaunter is placed in the monotypic genus Limnornis. The superficially similar straight-billed reedhaunter ... The**curve**-billed reedhaunter (Limnornis curvirostris) is a species of bird in the family Furnariidae. ... is sometimes also included in Limnornis, but evidence suggests it is closer to Cranioleuca spinetails than it is to the**curve**- ...###### Burnaby Velodrome

In 2000, the Burnaby Mountain Conservation

**Area**was formed, which includes the land under the Harry Jerome Sports Centre. The ... Walker, Ian (10 May 2008). "Steep Learning**Curve**". The Vancouver Sun. Postmedia Network Inc. Archived from the original on 17 ... "Item 1 - Burnaby Mountain Conservation**Area**Management Plan". Burnaby City Council. Archived from the original on 17 April 2015 ...**Curve**-shortening flow

For such

**curves**, if both sides of the**curve**have infinite**area**, then the evolved**curve**remains smooth and singularity-free for ... For a simple closed**curve**, the**area**enclosed by the**curve**shrinks, at the constant rate of 2π units of**area**per unit of time, ... As the points of any smooth simple closed**curve**move in this way, the**curve**remains simple and smooth. It loses**area**at a ... However, if one side of an unbounded**curve**has finite**area**, and the**curve**has finite total absolute curvature, then its ...###### Cliftonville **Curve**

Cliftonville was an

**area**of Hove which was developed speculatively as a "fashionable neighbourhood" in the mid-19th century. ... The**curve**includes a 535-yard (489 m) tunnel. The line, which is also known as the Cliftonville Spur, was named in reference to ... Cliftonville**Curve**is a short railway that links the West Coastway Line to the Brighton Main Line between Hove and Preston Park ... Construction of the**curve**allowed trains to travel between the Brighton Main Line and the West Coastway Line without having to ...###### Halton **Curve**

Map of

**area**showing route of Halton**Curve**North Cheshire Rail Users Group Network Rail Document mention Halton**curves**. ... "Ride the Halton**Curve**on 4 June! …". Mid Cheshire Railway Lines. 22 May 2011. Halton**Curve**Campaign Archived 2011-08-09 at the ... Halton**Curve**(now formally known as the Frodsham Single Line) is a short bi-directional railway line which links the Chester- ... 18.75m Halton**Curve**rail relaunch delayed by six months because of 'lack of trains'". Liverpool Echo. 24 September 2018. "1B16 ...###### Stadium (geometry)

With the same parameters, the

**area**of the stadium is A = π r 2 + 2 r a = r ( π r + 2 a ) {\displaystyle A=\pi r^{2}+2ra=r(\pi r ... However, unlike some other ovals such as the ellipses, it is not an algebraic**curve**because different parts of its boundary are ... All articles with unsourced statements, Articles with unsourced statements from February 2022, Piecewise-circular**curves**). ... Huang, Pingliang; Pan, Shengliang; Yang, Yunlong (2015). "Positive center sets of convex**curves**". Discrete & Computational ...###### Houdini (software)

This has led to a higher learning

**curve**than other comparable tools. It is one thing to know what all the nodes do - but the ... Houdini covers all the major**areas**of 3D production, including these: Modeling - All standard geometry entities including ... Polygons, (Hierarchical) NURBS/Bézier**Curves**/Patches & Trims, Metaballs Animation - Keyframed animation and raw channel ...###### Hastings Prototype House

A driveway

**curves**around from High Street to it. The house itself is a 21-foot (6.4 m) cubical steel frame structure on a ... Three steps lead down from the south side to the living**area**, which occupies the bulk of the first-floor space and the greatest ... Its completion in 1934 opened up the neighborhood around it, an**area**known as Uniontown, to subdivision and development. ...###### Sieve analysis

The

**curve**on the gradation graph is very steep, and occupies a small range of the aggregate. Gap gradation A gap gradation ... The large sieving**area**enables the sieving of large amounts of sample, for example as encountered in the particle-size analysis ... The**curve**is horizontal in the medium size range on the gradation graph. Open gradation An open gradation refers an aggregate ... On the gradation graph, it appears as a**curve**that is horizontal in the small size range. Rich gradation A rich gradation ...###### Manueline

... from the coastal

**areas**of Africa to the discovery of Brazil and the ocean routes to the Far East. Although the period of this ... sometimes consisting of three or more convex**curves**multiple pillars eight-sided capitals lack of symmetry conical pinnacles ...###### Earmuffs

Because the ears extend from the sides of the head to gather sound waves, they have a high skin surface-

**area**-to-volume ratio, ... This frequency dependence is reflected in the use of the A-weighting**curve**to describe the decibel level of an exposure (dB A ... His patent was for improved ear protectors, which he and his local employees manufactured in the Farmington**area**for nearly 60 ... According to OSHA, hearing aids should not be used in**areas**with dangerous noise levels. However, OSHA allows for the ...###### February 1909

... "learning

**curve**" and the "forgetting**curve**" After more than 40 years of silence, William H. Flood gave an interview to the New ... and that the**area**should be part of a Greater Serbia. The Austro-Hungarian Empire prepared to go to war with Serbia, which ...###### Line array

... while the

**curve**at the bottom acts as an in-fill for the**area**underneath the array that would otherwise be neglected Spiral ... Sound intensity is the acoustic power per unit**area**, and it decreases as the surface**area**increases since the acoustic power is ... Since the surface**area**of the curved surface of a cylinder = 2π r h, where r is the radius and h is the height, every doubling ... Since the surface**area**of a sphere = 4π r² where r is the radius, every doubling of the radius results in a four-fold increase ...###### Tennessee State Route 82

SR 269 turns north in the downtown

**area**and SR 82 continues east along Webb Road East through residential**areas**. The road ... The road runs through a mix of farm fields and woods with some homes and**curves**to the north, winding through more rural land. ... The highway then bends back to the northwest and heads through more rural**areas**with a few homes. The road turns north and then ... The road continues through rural**areas**before it enters Bell Buckle, where it becomes Webb Road West and passes a mix of fields ...###### Buenos Aires 1859 1p "In Ps" tete-beche pair

First the lower

**curve**of the "P" was excised, making it read "rs", and later it was modified again by removing the "Cu" and "o ... Each matrix had the denomination cut into the solid**areas**: "Dos Ps", "Tres Ps", "Cuato Ps" [sic] and "Cinco Ps". From these the ...###### Kefalos

Kampos and Onia follow the

**curve**of the bay for approximately 2 kilometres. The name Kefalos is often used for this**area**as ...###### ABC TV (Australian TV channel)

In the early years, ABC TV had been using Lissajous

**curves**with its initials, ABC TV, inside it as fillers in-between programs ... with other stations being established in state capitals and regional**areas**in the following years. In the 1960s and 1970s, the ... After concerns in some sections of the media that the 43-year-old Lissajous**curve**brand was to disappear completely, ABC ... After concerns in some sections of the media that the 43-year-old Lissajous**curve**logo was to disappear completely, ABC ...###### San Diego Gas & Electric

The utility's

**area**spans 4,100 square miles (10,600 square kilometers). SDG&E employs about 5,000 people. In 2004, the ... Peter Maloney (April 19, 2016). "SDG&E 'ahead of the**curve**' to meet California's 50% RPS with help from storage". Utility Dive ... and it is unknown why safeguards did not keep the outage limited to the Yuma**area**. By Friday morning on the 9th, power had been ... APS Works to Restore Service to Customers in Yuma**Area**Archived March 14, 2013, at the Wayback Machine, APS News Release, ...###### List of birds of Palestine

The avifauna of the Palestine region is unusually rich for so small an

**area**. Henry B. Tristram, who identified much of the ... short wings and long pointed bills which**curve**downwards. Cream-coloured courser (Cursorius cursor) Collared pratincole ( ... "Wadi Gaza one of the Important Bird**areas**in Gaza Strip". Palestine Wildlife Society. Archived from the original on 2011-08-25 ... The types of avifauna are not equally diffused over the whole**area**. The Palearctic species are found largely near the coast of ...###### Iowa Highway 25

The concurrency ends as the White Pole Road

**curves**to the southwest while Iowa 25 turns to the north. Continuing north through ... "**Area**Attractions". Whitepoleroad.com. White Pole Road Development Corporation. Archived from the original on February 20, 2012 ... the rolling hills of Guthrie County, Iowa 25 eases to the west through a series of S**curves**which aligns the road with 5th ...###### Euler diagram

**Curves**that do not overlap represent disjoint sets, which have no elements in common. Two

**curves**that overlap represent sets ... The correct equation must include this unshaded

**area**shown in boldface: "No Y is Z and ALL X is Y: therefore No X is Z" has the ... Each

**curve**divides the plane into two regions or "zones": the interior, which symbolically represents the elements of the set, ...

**Areas**are shaded to indicate that they contain no elements. Henri Milne -Edwards's (1844) diagram of relationships of ...

###### U.S. Route 36 in Colorado

At Byers, US 36 heads eastward on its own as a separate rural highway, while the I-70/US 40/US 287 overlap

**curves**to the ... US 36 enters Boulder on four-lane-wide 28th Street, where it serves the city's main shopping**area**. On the north side of Boulder ... Returning to Colfax Avenue east of Denver, the first part of I-70 in that**area**opened in 1961-1962, bypassing Watkins and ... Leaving the Boulder shopping district, US 36 crosses Boulder Creek and passes through the University of Colorado campus**area**as ...###### St Paul's Anglican Church, Proserpine

The Proserpine

**area**was first settled from the 1860s and agriculture became the main industry. An initial attempt at sugar cane ... Smaller in scale than on the exterior, the edges of the slab also**curve**upwards, pierced with regularly spaced square holes. ... The church is fronted by a lawn**area**with recent garden beds along the footpath. A gravel driveway runs along the eastern side ... Much of the present-day Proserpine town**area**occupies land formerly part of the plantation site. A stable sugar-growing ...###### Landstuhl station

The Landstuhl-Kusel railway branches off in the west and turns on a broad

**curve**almost at a right angle to the north. ... To the north is an industrial**area**. The western part of the station is bridged by state route 363. The Mannheim-Saarbrücken ... The northern and southeastern station**areas**served the loading of coal. There was a long loading ramp southwest of today's ... which was to be used primarily for transporting coal from Saar**area**to the Rhine. The line ran from Bexbach to the west via ...###### New York State Route 228

The road gradually

**curves**to the northeast, passing by brief wooded**areas**on its way into the hamlet of Catharine, where NY 228 ... Outside of Mecklenburg, the road crosses more rural**areas**in the town of Hector as it heads generally northeastward along ... Here, the valley and NY 228**curve**northeastward, following Taughannock Creek through eastern Schuyler County. The route remains ... crossing nearby railroad tracks and entering a more pronounced rural**area**north of town. ...###### Jacques-Cartier River

The

**area**covered by the drainage basin is for the most part undeveloped or protected, especially its source. In fact, 77% of ... then the southwest by forming two large**curves**until the confluence of the Cassian River (coming from the west); 10.4 ... The surface of the Jacques-Cartier River (except the rapids**areas**) is usually frozen from the beginning of December to the end ... This natural highway was used among others by Jesuit missionaries to reach the Lac Saint-Jean**area**during the 17th century. ...###### Maximum potential intensity

The bulk aerodynamic formula for the rate of heat input per unit

**area**at the surface, Q i n : k {\displaystyle Q_{in:k}} , is ... are**curve**-fit constants. When A = 28.2 {\displaystyle A=28.2} , B = 55.8 {\displaystyle B=55.8} , and C = 0.1813 {\displaystyle ... the total rate of net energy production per unit surface**area**is given by W i n = T s − T o T s ( C k ρ , u , Δ k + C d ρ , u ... The rate of energy loss per unit surface**area**from surface friction, W o u t {\displaystyle W_{out}} , is given by W o u t = C ...###### Fish measurement

It is a straight-line measure, not measured over the

**curve**of the body. Standard length measurements are used with Teleostei ( ... These data are used in many**areas**of ichthyology, including taxonomy and fisheries biology. Standard length (SL) is the length ...###### Hot Wheels Turbo Racing

The learning

**curve**is short and the long-term play life is moderate. Taking cues from Beetle Adventure Racing, Hot Wheels is ... Instead, the tracks are a mix of real-life terrain, industrial**areas**and other random places. If the designers had truly wanted ...###### Liquefied natural gas

A typical train consists of a compression

**area**, propane condenser**area**, and methane and ethane**areas**. The largest LNG train in ... As recently as 2003, it was common to assume that this was a "learning**curve**" effect and would continue into the future. But ... Many formulae include an S-**curve**, where the price formula is different above and below a certain oil price, to dampen the ... A number of scientists including Michael Faraday, James Joule, and William Thomson (Lord Kelvin) did experiments in this**area**. ...###### Blue Line (Washington Metro)

The joint line continues north along the CSX Railroad until it

**curves**to the east on an elevated bridge adjacent to the ... Washington Metropolitan**Area**Transit Authority. May 22, 2019. Retrieved March 6, 2020. "Metro stations on Blue/Yellow lines to ... Washington Metropolitan**Area**Transit Authority. March 19, 2012. Rush Plus is designed to ease crowding, improve the commuting ... 3) Maps and images of the**area**near the former route of the Rosslyn Connecting Railroad at the Arlington Cemetery Station of ...###### Tropical Storm Koni

The plane was later able to exit the

**area**of turbulence and land safely at Hong Kong International Airport. In Hong Kong, the ... during which time Koni began to**curve**westward. However, moderate wind shear conditions returned the following day, weakening ... The precursor to Koni developed as an**area**of deep convection within an active monsoon trough well south of Guam on July 12. ... Severe Tropical Storm Koni, known in the Philippines as Tropical Storm Gilas, caused moderate damage to**areas**of China and ...###### Kew Gardens

Within the conservation

**area**is a cottage that was built sometime before 1771 for Queen Charlotte by her husband George III. It ... The minimalist-styled bridge is designed as a sweeping double**curve**of black granite. The sides of the bridge are formed of ... The compost heap is in an**area**of the gardens not accessible to the public, but a viewing platform, made of wood which had been ... The conservatory has an**area**of 4,499 square metres (48,430 sq ft; 0.4499 ha; 1.112 acres). As it is designed to minimize the ...###### DeepScale

The paper claimed that the SqueezeNAS neural networks outperform the speed-accuracy tradeoff

**curve**of Google's MobileNetV3 ... and drivable**area**identification. To accomplish this, Carver uses three neural networks which run in parallel. While running in ...###### North Central Freeway (Washington, D.C.)

... tunnel in the Brookland

**area**. At the point where the railroad**curves**to the southwest, the freeway would continue south and ... In 1968, the U.S. National Capital Planning Commission released an updated Major Transportation Plan for the D.C.**area**which ... Tunnels would be constructed in the vicinity of Montgomery College, and the freeway would be depressed in the Brookland**area**. ... paralleling the B&O railroad corridor as far as the Brookland**area**, where it would have entered a 3/4-mile tunnel south of ...**Area** bounded by polar **curves** (video) | Khan Academy

And in polar coordinates I wont say were finding the

**area**under a**curve**, but really in this example right over here we have a ... How do I know exactly which function to integrate first when asked about the**area**enclosed between two**curves**? In order to get ... Voiceover] We now have a lot of experience finding the**areas**under**curves**when were dealing with things in rectangular ... And what I wanna do in this video is come up with a general expression for this**area**in blue. This**area**that is bounded, I ...###### Definite integrals and **areas** under the **curve** | Physics Forums

Homework Statement Find the

**area**under the cosine**curve**y=cosx from x=0 to x=b, where 0 is less than b is less than or equal to ... Suggested for: Definite integrals and**areas**under the**curve**Find the**area**under the**curve**... Find the**area**under the cosine**curve**y=cosx from x=0 to x=b, where 0 is less than b is less than or equal to pi/2.. Homework ...**Area**=the limit as n approaches infinity of Sn. Substituting x=b/n, Sn=(b/n)[sin(b/2)*cos((n+1)b/2n)]/sin(b/2n). Now, this is ...###### The euro **area** labour market through the lens of the Beveridge **curve**

The Beveridge

**curve**for the euro**area**and for the five largest euro**area**countries ...**curve**and the B C**curve**via the matching function. Figure A.1 shows the w - θ space that includes the job creation condition J ... The Beveridge**curve**for the United States has not shown large outward shifts such as those in the euro**area**. Diamond and Şahin[ ... The euro**area**labour market through the lens of the Beveridge**curve**. Publications Loading…. ...###### Classroom Activities: Definite Integrals and **Area** Under a **Curve** - Texas Instruments - content

This activity explores the concept of the solution to a definite integral as the

**area**under a**curve**. ... Be able to use the graphing calculator to find the**area**bounded by a**curve**and the x-axis through the calculators integration ... This activity explores the concept of the solution to a definite integral as the**area**under a**curve**. ... to access secure**areas**of the TI site, or to manage your configured cookie preferences).. Always On. ...###### Search of: **Area** Under **Curve** AND plasma concentration AND decay AND Pfizer - Modify Search - ClinicalTrials.gov

###### Comparing the **areas** under two or more correlated receiver operating characteristic **curves**: a nonparametric approach

... Biometrics ... This paper presents a nonparametric approach to the analysis of

**areas**under correlated ROC**curves**, by using the theory on ...**curve**. The**curve**is constructed by varying the cutpoint used to determine which values of the observed variable will be ... When two or more empirical**curves**are constructed based on tests performed on the same individuals, statistical analysis on ...**Area** bounded by a **Curve** (examples, solutions, worksheets, videos, activities)

How to find the

**area**between a**curve**and a line using integration, examples and step by step solutions, A Level Maths ... C2 Integration -**Areas**above + below**curves**. This video shows how to find**areas**above and below**curve**, this is typical of an ... C2 Integration -**area**between and**curve**and a line. Example:. 1. The diagram shows a sketch of part of the**curve**with equation ... Find the**area**of the region bounded by the**curve**and the line.. 2. The diagram shows a sketch of part of the**curve**with ...###### Estimate the **area** under a **curve**

... we will estimate the

**area**under a**curve**by forming trapeziums from the x axis. ... Estimate the**area**under a**curve**. In this lesson, we will estimate the**area**under a**curve**by forming trapeziums from the x axis. ... Estimate the**area**under a**curve**. Key Stage 4,. Maths,. Further graphs (Gradients/**Area**of**curves**) ... Estimate the**area**under a**curve**. Dont worry if you get a question wrong! Forgetting is an important step in learning. We will ...###### GraphPad Prism 9 **Curve** Fitting Guide - **Area** under the ROC **curve**

... and Interpolation section of options for simple logistic regression is to generate an ROC

**curve**and to calculate the**area**under ... section of options for simple logistic regression is to generate an ROC**curve**and to calculate the**area**under this**curve**(AUC ... Learn more about interpreting AUC. The results for the**area**under the ROC**curve**that Prism reports include: ...**Area** under the Standard Normal **Curve**

Learn how to find the

**area**under the standard normal**curve**using the standard normal distribution table ...**Area**under the standard normal**curve**. Learn how to calculate the**area**under the standard normal**curve**. This is an important ... Find the**area**between z = 1.32 and z = 2.54. This**area**is shown in green. Notice that**area**from z = 0 to z = 1.32 plus**area**in ... Because the normal**curve**is symmetric about the mean, the**area**from z = -1.32 to z = 0 is the same as the**area**from z = 0 to z ...###### Euro **area** banks' interest rate risk exposure to level, slope and curvature swings in the yield **curve** | Deutsche Bundesbank

Euro

**area**banks interest rate risk exposure to level, slope and curvature swings in the yield**curve*** Print ... Euro**area**banks interest rate risk exposure to level, slope and curvature swings in the yield**curve**Discussion paper 24/2017: ... In the press**area**, you will find press releases, speeches, guest contributions and interviews with Bundesbank Executive Board ...###### Calibration of Runoff **Curve** Numbers and Rational Runoff Coefficients for the Kansas Metropolitan **Area**

... dc.contributor.advisor. ... Calibration of Runoff

**Curve**Numbers and Rational Runoff Coefficients for the Kansas Metropolitan**Area**. ...**area**streamflow data and recommends changes to the current Section 5600 storm-drainage design criteria for the Kansas City**area**... The runoff**curve**number (CN) and the rational runoff coefficient (C) for undeveloped land are key inputs to common methods for ...###### Clustered functional domains for **curves** and corners in cortical **area** V4 | eLife

**Curves**and corners are separately encoded by neurons clustered into functional domains in macaque V4. ... A) Cell map of

**curve**/corner index (CVCNI). Positive CVCNI indicates preference for

**curves**over corners and vice versa.

**Curve**- ... Using a large range of contour feature stimuli including bars,

**curves**, and corners (Figure 1A), we scanned a large

**area**(3.4 × ... where MaxRespcurve is the neurons maximum response to

**curve**stimuli and MaxRespother is the neurons maximum response to other ...

###### The **Area** Over a Receiver Operating Characteristic (ROC) **Curve** as an Index of Diagnostic Inaccuracy - Wolfram Demonstrations...

This Demonstration plots the change the relative change the rate of change and the relative rate of change of the

**area**under ... blue plot and the**area**over orange plot the receiver operating characteristic ROC**curve**of a diagnostic test as the uncertainty ... is the**area**under an ROC**curve**and. is the**area**over the ROC**curve**for an uncertainty of measurement , the changes and are ... the**area**under an ROC**curve**is used as an index of the diagnostic accuracy of the respective test. The**area**under the**curve**...**Area** Under the **Curve** Excel, Graphs: Find in Easy Steps - Statistics How To

How to find the

**area**under the**curve**in Excel in simple steps, with examples & short video. Hundreds of definitions and ... How to Find the**Area**Under**Curve**in Excel. What is an "**Area**Under the**Curve**?". The**area**under a**curve**is the**area**between the ... The**area**function can calculate an**area**(a) above the**curve**(b) below the**curve**or (c) both above and below.. A couple of very ... "**Area**under a**curve**" image created at Desmos.com.. CITE THIS AS:. Stephanie Glen. "**Area**Under the**Curve**Excel, Graphs: Find in ...###### Dakine Pickup Pad DLX **Curve** - Now Bikes | St. Paul and Minneapolis **area**

We also offer Free Delivery in our Metro

**area**for orders over $500.00. Give us a call if you are out of our delivery**area**. ... The Dakine Pickup Pad DLX**Curve**is made to fit the curved shape and back-up camera location of late-model, full-size Dodge, and ... This item is eligible for delivery in select**areas**. View available options in checkout. ...**Area** Under Simple **Curves**

We can relate to it in mathematics with the

**area**under a**curve**. It is important to compute the**area**under**curves**plotted on a ... Well learn about the use of Integral for computing the**Area**under**curves**. ... the**Area**under an umbrella is the**area**that is protected from getting drenched. ... Definition of**Area**Under**Curves**. The**area**A under the**curve**f(x) bounded by x = a and x = b is given by: $$ {A = \int_{a}^{b} f ...###### Theoretical investigation of variable **area** ejectors | **CURVE**

Items in

**CURVE**are protected by copyright, with all rights reserved, unless otherwise indicated. They are made available with ... Please contact**curve**@carleton.ca with any concerns, questions or feedback. Sitemap available here. ...**CURVE**- Carleton University Research Virtual Environment A service of Carleton University Library ...###### Application of dimensionless sediment rating **curves** to predict suspended-sediment concentrations, bedload, and annual sediment...

Water Resources Mission

**Area**- Headquarters USGS Headquarters. 12201 Sunrise Valley Drive. Reston, VA 20192. United States ... Application of dimensionless sediment rating**curves**to predict suspended-sediment concentrations, bedload, and annual sediment ... Application of dimensionless sediment rating**curves**to predict suspended-sediment concentrations, bedload, and annual sediment ... completed a study to evaluate the use of dimensionless sediment rating**curves**(DSRCs) to accurately predict suspended-sediment ...###### When Life Throws You a **Curve** Ball

###### Cornerstone introduces The **Curve** project at Cityscape exhibition - Daily News Egypt

The

**Curve**is located in the NACs R8 district, and will consist of a built-up**area**of 18%, which stands at less than the ... Boulos added that the company plans to deliver the compound by the end of 2023, with unit**areas**ranging from 80 sqm to 320 sqm ... Cornerstone introduces The**Curve**project at Cityscape exhibition. Companys project, located at NAC, comes with nine-year ... Additionally, the company is offering a long and balanced payment plan for The**Curve**project units of up to nine years, which ...###### Interpreting Epidemic (Epi) **Curves** During Foodborne Outbreaks | CDC

Shaded

**area**: Some epi**curves**have a shaded**area**labeled "Illnesses that began during this time may not yet be reported." This ... An epidemic**curve**, also known as an epi**curve**, shows the number of illnesses in an outbreak over time. During an ongoing ... Analyzing Epi**Curves**. An epi**curve**provides key information about an outbreak, including how quickly it is growing, what type ... This epi**curve**shows a total of 1,127 illnesses in this outbreak, one of the largest Salmonella outbreaks in the past 50 years ...###### Lizard Island Research Station; Kaplan-Meier survival **curves** for unfed... | Download Scientific Diagram

Shaded

**areas**are 95% confidence intervals. from publication: Effect of Acute Seawater Temperature Increase on the Survival of a ... Kaplan-Meier survival**curves**for unfed gnathiids per temperature treatment. ... Lizard Island Research Station; Kaplan-Meier survival**curves**for unfed gnathiids per temperature treatment. Shaded**areas**are 95 ... Kaplan-Meier survival**curves**for unfed gnathiids per temperature treatment. Shaded**areas**are 95% confidence intervals./,,/a,. ...###### Improvements to point counting on hyperelliptic **curves** of genus two | School of Mathematics and Statistics | School of...

This is the current state of the art for elliptic

**curves**. Motivated by the fact that Jacobians of hyperelliptic**curves**of genus ... Improvements by Elkies and Atkin lead to an even faster method for elliptic**curves**, known as the SEA algorithm. ... Schoofs algorithm is a standard method for counting points on elliptic**curves**defined over finite fields of large ... two have recently been found to be good alternatives to elliptic**curves**in cryptography, we investigate the possibility of ...###### Natalizumab Beneficial in Secondary Progressive MS?

###### Emerging Infections: Getting Ahead of the **Curve** - Volume 1, Number 1-January 1995 - Emerging Infectious Diseases journal - CDC

... delivery of web content that based on self-identified

**area**of interests. ... Emerging Infections: Getting Ahead of the**Curve**On This Page Early History of Infectious Diseases 19th Century Discoveries Lead ... We cannot overstate the role of behavioral science in our effort to get ahead of the**curve**with emerging infections. Having the ... Clearly, broader coalitions are needed, and communication must improve if we are to get ahead of the**curve**. This new periodical ...**Area** Under **Curve** - SASsy Fridays

Posts about

**Area**Under**Curve**written by Michelle ...**Area**Under**Curve**.**Area**Under the**Curve**. Calculating the**Area**...**Area**Under the**Curve**Follow Blog via Email. Enter your email address to subscribe to this blog and receive notifications of new ... by MichellePosted in**Area**Under**Curve**, Data Step, GPLOT, LAG, PROCs1 Comment ... The presentation explains the process of … Continue reading**Area**Under the**Curve**...###### Techmeme: Exclusive: Next-generation BlackBerry **Curve** appears, brings specs with it (Jonathan S. Geller/BGR)

Barbara E. Hernandez / NBC Bay

**Area**:. No Home Button for Apple iPhone or iPad? ... Next-Gen BlackBerry**Curve**Leaks Too, NFC Included. Ross Miller / Engadget:. BlackBerry**Curve**Apollo leak provides image, ... BlackBerry Apollo to be the Next**Curve**, Also Has NFC?. Phone Arena:. Latest upcoming BlackBerry**Curve**model breaks cover & ... First look: BlackBerry**Curve**Apollo with 7.2Mbps HSPA, NFC. Nick Marshall / Electricpig.co.uk:. BlackBerry Apollo adds NFC to ...###### CRV price prediction as **Curve** DAO unveils stablecoin plans - Astaga

Binance Coin Revives Its Bullish Strength Above $290; Will Bulls Defend This

**Area**?. November 25, 2022. ...**Curve**DAO to launch a stablecoin. The CRV worth has been in a powerful bullish momentum up to now few days as traders transfer ...**Curve**DAO worth is hovering after the builders introduced that they are going to launch a brand new stablecoin that may assist ...**Curve**rally accelerated after the community introduced that itll launch a brand new stablecoin. It rose to a excessive of $ ...###### Design choices: Empirical recommendations for designing two-dimensional finger-tracking experiments | SpringerLink

**Area**under the

**curve**(AUC, in px2):

**Area**between the actual movement and the perfect line (deviations towards the opposing ... The circular

**area**at the bottom represents the starting

**area**; the two on the top left and top right represent the target

**areas**... Upon clicking or touching the screen within the starting

**area**, the starting

**area**disappeared, and two target

**areas**appeared ( ...

**Area**under the

**curve**. Movements showed significantly greater spatial deviations for current incompatible trials (8519 px2) than ...

Calculus2022ReceiverGraphBlackBerry CurveOutbreaksMonkeypoxProbabilityEpidemic curveConcentrationGraphsEquationFindSearchIntegrationCalculate the areaIntegralBell curveCalibrationCoefficientShapeHistogramStablecoinTangentImaging confirmedAnalyzeLessonShoulderLoginDifferencesTunnelHigherStandardContentAlternativesAnalysisMeasuresUrbanAheadEvaluatePhillipsCOVIDIntuitionCaliforniaPointsLeftCodyDecreaseEstimateFrameworkIncreasesFloodRelationDataSingleExamVersusCumulativeMeasurementFormalAmericaMethod

###### Calculus4

- Use calculus to find the area of R. (onlinemathlearning.com)
- Using calculus, find the exact area of R. (onlinemathlearning.com)
- In calculus, you find the area under the curve using definite integrals . (statisticshowto.com)
- In calculus, an area function finds the area between a function and the x-axis. (statisticshowto.com)

###### 20221

- From 1 January to 4 July 2022, 6027 laboratory confirmed cases of monkeypox and three deaths have been reported to WHO from 59 countries/territories/areas in five WHO Regions (African Region, Region of the Americas, Eastern Mediterranean Region, European Region, Western Pacific Region) (Table 1). (who.int)

###### Receiver10

- When a test is based on an observed variable that lies on a continuous or graded scale, an assessment of the overall value of the test can be made through the use of a receiver operating characteristic (ROC) curve. (nih.gov)
- This Demonstration plots the change, the relative change, the rate of change and the relative rate of change of the area under (blue plot) and the area over (orange plot) the receiver operating characteristic (ROC) curve of a diagnostic test as the uncertainty of measurement increases from 0 to a user-defined upper bound. (wolfram.com)
- Receiver Operating Characteristic Curves and Uncertainty of Measurement' from the Wolfram Demonstrations Project-A Wolfram Web Resource. (wolfram.com)
- An Area Under the Receiver-Operator Curve (AUC) Metric is a classifier performance measure based on the area of an ROC curve . (gabormelli.com)
- Wikipedia, 2015) ⇒ http://en.wikipedia.org/wiki/Receiver_operating_characteristic#Area_under_the_curve Retrieved:2015-7-18. (gabormelli.com)
- They use a computer and GPS receiver to create a boundary around each field known as a geofence, and they can program DOT to avoid obstacles such as utility poles, wet areas, and ditches to within less than an inch of accuracy. (therecord.com)
- Sensitivity, specificity, DOR (diagnostic odds ratio), LR ± (positive and negative likelihood ratio) and AUC (area under receiver operating characteristic-curve) were summarized with a bivariate model. (nih.gov)
- The Meaning of the Area under a Receiver Operating Characteristic (ROC) Curve. (bvsalud.org)
- Receiver operating characteristic curves were constructed to evaluate WC, WHpR, WHtR and NC as screening indices for overweight and obesity as categorized by body mass index centiles. (who.int)
- Receiver Operating Characteristic curves were constructed based on the scores of the reading and writing tasks. (bvsalud.org)

###### Graph12

- Develop intuition for the area enclosed by polar graph formula. (khanacademy.org)
- What does the area inside a polar graph represent (kind of like how Cartesian graphs can represent distance, amounts, etc. (khanacademy.org)
- This question is on areas under a graph using integration methods. (onlinemathlearning.com)
- The area under a curve is the area between the line of a graph (which is often curved) and the x-axis. (statisticshowto.com)
- Find the area under curve in Excel for the graph below, from x = 1 to x = 6. (statisticshowto.com)
- Before beginning the discussion, it should be quite clear that it makes sense to talk about the area under a curve only when you have a graph of that curve . (toppr.com)
- It is evident from the graph that the area below the curve is actually unbounded! (toppr.com)
- Calculate the graph indicate the rest of confirmatory factor analysis using symmetry and software that require no matter how do relatively speaking, and critique of writing the curve table? (givingtreeyoga.org)
- If you build the Riemann sum rectangle between the graph and the axis and calculate its vertical side as the upper function minus the lower (or right minus left if you use horizontal rectangles) you will always get the correct integral for the area. (teachingcalculus.com)
- The Graph view shades the region under the curve, and the Infobox on the left displays the calculated area under the curve. (dummies.com)
- The angle of attack and CL are related and can be found using a Velocity Relationship Curve Graph (see Chart B below). (nasa.gov)
- Use the Velocity Relationship Curve Graph chart below, Chart B, to find the appropriate CL from the given angle of attack. (nasa.gov)

###### BlackBerry Curve6

- Exclusive: Next-generation BlackBerry Curve appears, brings specs with it - That BlackBerry 8520 feeling a bit outdated? (techmeme.com)
- Well, we might have just what you've been waiting for - the next generation BlackBerry Curve. (techmeme.com)
- RIM's BlackBerry line up is diverse, like any other smartphone range, and their entry-level version is the BlackBerry Curve. (brighthub.com)
- Compare the BlackBerry Curve 9310 and Samsung T159 below. (wirefly.com)
- We pit the BlackBerry Curve 9310 vs Samsung T159 so that you can see which device matches your needs. (wirefly.com)
- The BlackBerry Curve 9310 is a smartphone that has the power of BlackBerry in the familiar BlackBerry form but with new. (wirefly.com)

###### Outbreaks1

- This epi curve shows a total of 1,127 illnesses in this outbreak, one of the largest Salmonella outbreaks in the past 50 years. (cdc.gov)

###### Monkeypox1

- The clinical presentation of monkeypox cases associated with this outbreak has been atypical, as many cases in newly-affected areas are not presenting with the classically described clinical picture for monkeypox (fever, swollen lymph nodes, followed by centrifugal rash). (who.int)

###### Probability5

- This area can be interpreted as the probability that z assumes a value between 0 and 1.32. (basic-mathematics.com)
- Calibrated curve numbers decrease slightly with decreasing annual exceedance probability. (ku.edu)
- Since probability that curve of people scored compared to. (givingtreeyoga.org)
- So without even the areas of under the table and columns and a probability distribution from it. (givingtreeyoga.org)
- The Area Under the ROC curve is the probability that a classifier will be more confident that a randomly chosen positive example is actually positive than that a randomly chosen negative example is positive. (gabormelli.com)

###### Epidemic curve2

###### Concentration8

- Basin lag times and times of concentration were computed with the new calibrated equations for the Kansas City area developed by the University of Kansas (McEnroe et al. (ku.edu)
- IMSEAR at SEARO: Amikacin: Area under curve for once daily dose and its correlation with plasma concentration at six hours post infusion. (who.int)
- At present the recommended dose is once daily and the recommended monitoring parameters are the area under concentration time curve and the six-hour (range 146-180) for the area under curve and 6.79 milligrams per liter (range 5.6-7.9) for the six-hour plasma concentration post-infusion. (who.int)
- The correlation of the area under curve and the six-hour plasma concentration post-infusion was reported in a linear equation with significance. (who.int)
- After single i.p. injections of TRZ or KET in separate groups of control mice, brain concentrations of TRZ exceeded those in serum [brain/serum area under the concentration curve (AUC) ratio, 5.0], whereas brain/serum AUC ratios for KET were approximately 0.5. (aspetjournals.org)
- AUC, area under the concentration curve. (aspetjournals.org)
- As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (bvsalud.org)
- Area under plasma concentration-time curve. (who.int)

###### Graphs1

- This was the final lesson in the unit Further graphs (Gradients/Area of curves) . (thenational.academy)

###### Equation5

- Third, aggregate measures of labour market tightness and efficiency are used in a standard wage Phillips curve equation to measure their marginal impact. (europa.eu)
- In figure 2, the curve C has equation y = 6x - x 2 and the line L has equation y = 2x. (onlinemathlearning.com)
- Figure 2 shows a sketch pf part of the curve with equation y = 10 + 8x + x 2 - x 3 . (onlinemathlearning.com)
- 1. The diagram shows a sketch of part of the curve with equation y = x(4 - x) and the line with equation y = x. (onlinemathlearning.com)
- Sometimes it is not quite so obvious what the equation of either the top or bottom curve is. (astarmathsandphysics.com)

###### Find25

- Find the area under the cosine curve y=cosx from x=0 to x=b, where 0 is less than b is less than or equal to pi/2. (physicsforums.com)
- This video shows how to find areas above and below curve, this is typical of an exam situation. (onlinemathlearning.com)
- Find the area of the region bounded by the curve and the line. (onlinemathlearning.com)
- Find the area of the shaded region OAC. (onlinemathlearning.com)
- A portion of the table is reproduced below to show how to find the area. (basic-mathematics.com)
- You just need to find the area under the normal curve between z = -1.32 and z = 0. (basic-mathematics.com)
- To find the area from z = 0 to z = 2.54, use the table to see that it is equal to .4945. (basic-mathematics.com)
- In the press area, you will find press releases, speeches, guest contributions and interviews with Bundesbank Executive Board members as well as further press materials. (bundesbank.de)
- When tested with hexagonal-segment stimuli, we find that stimulus smoothness is the cardinal difference between curve and corner selectivity in V4. (elifesciences.org)
- Drawing the Normal curve and shading the desired area helps one to know how to find the desired area. (givingtreeyoga.org)
- Unlike distributions is between one but if you find a table of areas under the normal curve in data have a standard normal. (givingtreeyoga.org)
- An easy to find these types of the mean for different ranges of interest you the entire area under the table areas of normal curve and confident in psychology and stddev value. (givingtreeyoga.org)
- In this page area between two curves we are going to see example problems to understand how to find area between curves. (onlinemath4all.com)
- For that let us find point of intersection of two curves. (onlinemath4all.com)
- How To Find Area Under A Normal Curve? (blurtit.com)
- These values are checked in area table to find the value of area under the curve. (blurtit.com)
- How To Find The Area Of A Polygon? (blurtit.com)
- Can You Find The Following Area Under The Standard Normal Curve Between Z+-1.88 And Z=2.10? (blurtit.com)
- Then find the area of all the parts and in the end add up all the answers. (blurtit.com)
- Find the area under the normal distribution curve between z = -1.34 and z = 2.95? (blurtit.com)
- Can You Find The Area Under The Standard Normal Curve? (blurtit.com)
- A. From a table of values, we find that the area from 0 to .94 is .32639, so the area from -Infinity. (blurtit.com)
- Can You Find The Percent Of Total Area Between Z = -2.49 And Z = 1.19 Under A Normal Curve That Is? (blurtit.com)
- Area of a sphere = 4(pi)r^2You need the radius of the star to find the surface area. (blurtit.com)
- You can also automatically find the curve of best fit by performing a regression. (dummies.com)

###### Search1

- We analyse the importance of these two concepts for wage developments using a simple version of the search and matching model, where unemployment, wages and vacancies are jointly determined and the Beveridge curve features prominently. (europa.eu)

###### Integration3

- This question is on the area between a curve and a line using integration. (onlinemathlearning.com)
- This entry was posted in Integration , Integration Applications and tagged application , area , area between curves , Jan. , Riemann sum by Lin McMullin . (teachingcalculus.com)
- Indian outsourcers say they are moving up the value curve, from primarily software coding and maintenance to new areas such as IT consulting, systems integration, infrastructure management, package implementation and product development. (computerworld.com)

###### Calculate the area5

- This LearningCheck™ document is a good review of how to calculate the area under the normal curve given certain scenarios. (ti.com)
- One option Prism provides in the Classification and Interpolation section of options for simple logistic regression is to generate an ROC curve and to calculate the area under this curve (AUC). (graphpad.com)
- Learn how to calculate the area under the standard normal curve. (basic-mathematics.com)
- Calculate the area under standard normal curve between two points. (mathworks.com)
- It is also common to calculate the Area Under the ROC Convex Hull (ROC AUCH = ROCH AUC) as any point on the line segment between two prediction results can be achieved by randomly using one or other system with probabilities proportional to the relative length of the opposite component of the segment. (gabormelli.com)

###### Integral1

- Use the Integral tool to display the area under a curve. (dummies.com)

###### Bell curve2

- A negative score in the z-table and respresent the area under the bell curve to the. (givingtreeyoga.org)
- The bell curve : intelligence and class structure in American life / Richard J. Herrnstein, Charles Murray. (who.int)

###### Calibration2

- This document describes the calibration of these inputs with Kansas City-area streamflow data and recommends changes to the current Section 5600 storm-drainage design criteria for the Kansas City area. (ku.edu)
- Quantitation is based on peak area ratios interpolated against a six-point aqueous calibration curve. (cdc.gov)

###### Coefficient2

- The runoff curve number (CN) and the rational runoff coefficient (C) for undeveloped land are key inputs to common methods for estimating flood quantiles. (ku.edu)
- Coefficient alpha and the curve to take a single point where can take an easy. (givingtreeyoga.org)

###### Shape2

- The Dakine Pickup Pad DLX Curve is made to fit the curved shape and back-up camera location of late-model, full-size Dodge, and Ford tailgates. (nowbikes-fitness.com)
- The full shape of the epi curve is clear only after the outbreak is over. (cdc.gov)

###### Histogram1

- Because area under a histogram describes what part of the data lies in any region, and we could figure out the exact number here. (givingtreeyoga.org)

###### Stablecoin4

- Curve rally accelerated after the community introduced that it'll launch a brand new stablecoin. (astaga.com)
- Curve DAO worth is hovering after the builders introduced that they are going to launch a brand new stablecoin that may assist to facilitate funds within the ecosystem. (astaga.com)
- Curve DAO's stablecoin launch comes at a time when many different decentralised platforms are launching their very own cash. (astaga.com)
- Curve Finance founder Michael Egorov shared the stablecoin project whitepaper and mathematical formulas on his GitHub account. (newstextarea.com)

###### Tangent2

- The Tangent tool can be used to draw a tangent line to the curve. (dummies.com)
- By using numerical methods it is possible to associate the resulting curve with a tangent, which can be projected from historical data to estimate potential undiscovered reserves. (searchanddiscovery.com)

###### Imaging confirmed1

- Single-cell resolution imaging confirmed that curve- or corner-selective neurons were spatially clustered into such domains. (elifesciences.org)

###### Analyze2

- Enter your free to analyze errors in the area from various points along the curve the table? (givingtreeyoga.org)
- Analyze→Curve Fit. (dummies.com)

###### Lesson2

- In this lesson, we will estimate the area under a curve by forming trapeziums from the x axis. (thenational.academy)
- We also saw that in the lesson about standard normal distribution that the area in red plus the area in blue is equal to 0.5. (basic-mathematics.com)

###### Shoulder1

- Narrow roadway with minimal shoulder in a curve. (cdc.gov)

###### Login1

- If you are the author, please login to your Author Area where you can update all of your links and other information. (readersfavorite.com)

###### Differences3

- When two or more empirical curves are constructed based on tests performed on the same individuals, statistical analysis on differences between curves must take into account the correlated nature of the data. (nih.gov)
- I know that there simply are cultural differences between the French and the British in the child-rearing area which complicate the business of handing over our kids to their care. (wheretoskiandsnowboard.com)
- Although the synthetic and original data yielded overall nearly the same results, there were exceptions that included an odds ratio on either side of the null in multivariable analyses (0.97 vs 1.01) and differences in the magnitude of epidemic curves constructed for zip codes with low population counts. (jmir.org)

###### Tunnel2

- The tunnel tracks curve around to the other side of the peninsula and follows the "coastline" to points south. (railpictures.net)
- I had been delivering freight of all kinds to the Tacoma area for years and never did know that there was a long railroad tunnel there. (railpictures.net)

###### Higher6

- You could also talk about areas under curves of higher dimensions but you'll encounter such problems only when you do some higher studies, for example - the umbrella we just talked about! (toppr.com)
- Schoof's algorithm is a standard method for counting points on elliptic curves defined over finite fields of large characteristic, and it was extended by Pila to higher-dimensional abelian varieties. (edu.au)
- The Curve 9380 is also being aimed more towards higher end, entry-level consumers, which is an interesting choice. (brighthub.com)
- The SVM model showed the areas under the curve of 0.731 in the external datasets, which is higher than those of the ANN model (0.729) and the screening score model (0.712), respectively. (hindawi.com)
- Higher independence to work in any cooking area. (teka.com)
- Snow clearing in residential areas starts only after higher priority areas have been completed. (fortsask.ca)

###### Standard6

- However, the quantitative implications for wages differ only marginally from those of the standard Phillips curve approach. (europa.eu)
- Overall, labour market efficiency provides an important qualitative margin of labour market functioning that is not captured in standard wage Phillips curve specifications. (europa.eu)
- Table Z Areas under the standard normal curve negative Z Second decimal place in z 009 00 007 006 005 004 003 002 001 000 z 00000 39. (givingtreeyoga.org)
- Standard normal curve areas under a normally distributed data have to figure out how well. (givingtreeyoga.org)
- Round to four decimal places as needed 1 Tables of Areas under the Normal Curve use TI 34 Not the Table TABLE V Standard Normal Distribution. (givingtreeyoga.org)
- When mean = 0 and Sd = 1, normal distribution change into standard normal distribution and curve is known as standard normal curve. (blurtit.com)

###### Content4

- Second, we look at the information content behind market tightness and job matching efficiency to analyse the euro area labour market and its cyclical conditions. (europa.eu)
- These cookies perform functions like remembering presentation options or choices and, in some cases, delivery of web content that based on self-identified area of interests. (cdc.gov)
- nodeType":"document","data":{},"content":[{"nodeType":"paragraph","data":{},"content":[{"nodeType":"text","value":"The WHO coronavirus (COVID-19) dashboard presents official daily counts of COVID-19 cases, deaths and vaccine utilisation reported by countries, territories and areas. (who.int)
- marks":[],"data":{}}]},{"nodeType":"paragraph","data":{},"content":[{"nodeType":"text","value":"The designations employed and the presentation of these materials do not imply the expression of any opinion whatsoever on the part of WHO concerning the legal status of any country, territory or area or of its authorities, or concerning the delimitation of its frontiers or boundaries. (who.int)

###### Alternatives2

- Motivated by the fact that Jacobians of hyperelliptic curves of genus two have recently been found to be good alternatives to elliptic curves in cryptography, we investigate the possibility of applying the improvements of Elkies and Atkin to Pila's point counting algorithm for such varieties. (edu.au)
- The results of this analysis facilitate the evaluation of investment alternatives for future exploration focusing the activity into areas that still have remaining potential. (searchanddiscovery.com)

###### Analysis7

- This paper presents a nonparametric approach to the analysis of areas under correlated ROC curves, by using the theory on generalized U-statistics to generate an estimated covariance matrix. (nih.gov)
- Combining cortical population responses with single-neuron analysis, our results reveal that curves and corners are encoded by neurons clustered into functional domains in V4. (elifesciences.org)
- These types of problems fall under the category of the analysis of area under curves, which is going to be our topic of discussion right now. (toppr.com)
- In the latest "area under the curve" (AUC) analysis, natalizumab was associated with a 77% reduction in the 9 Hole Peg Test time score, reflecting improved finger dexterity. (medscape.com)
- Problems in the analysis of growth and linear curves. (givingtreeyoga.org)
- Here to item analysis of areas under the table. (givingtreeyoga.org)
- Use of this three-step analysis and its potential use in guidingpublic health interventions are demonstrated for selected countries and subnational areas of the WorldHealth Organization South-East Asia Region, together with the Republic of Korea as a reference. (who.int)

###### Measures5

- In fact, as the plots of this Demonstration show, the relative change, the rate of change and the relative rate of change of the area over an ROC curve versus the uncertainty of measurement are greater than the absolute value of the respective measures of the area under the ROC curve for the same populations. (wolfram.com)
- To the best of the author's knowledge, measures of the area over the ROC curve versus the uncertainty of measurement have not been discussed in the literature except for [2]. (wolfram.com)
- Any time for analyzing repeated measures the areas. (givingtreeyoga.org)
- and (3) determining geospatial and temporal COVID-19-related measures and outcomes, and constructing their epidemic curves. (jmir.org)
- Thus, the average annual loss in different scenarios was estimated, considering the cost-benefit of mitigation measures proposed in the drainage master plan of São Carlos city, evaluating the uncertainties of the use of one-dimensional hydraulic-hydrological models to obtain flood heights and to quantify the direct and indirect damages of this area of study. (usp.br)

###### Urban2

- In aggregate, these watersheds have physical characteristics that are similar to those of undeveloped land and urban open space in the Kansas City area. (ku.edu)
- For antenatal care and childbirth, families in urban and rural areas are not always accompanied by qualified health personnel, thus compromising the well-being and future of the child. (who.int)

###### Ahead3

- I'm happy to say we've been ahead of the curve in addressing this issue with our community partners. (mynewsletterbuilder.com)
- When you're driving you make those decisions about what areas to avoid while you're in the cab, but now you have to plan ahead. (therecord.com)
- Cyber-security is still a relatively new area of specialization for automakers, but it's one they need to take seriously to ensure they are ahead of the curve. (darkreading.com)

###### Evaluate2

- The U.S. Geological Survey, in cooperation with the Minnesota Pollution Control Agency and the Minnesota Department of Natural Resources, completed a study to evaluate the use of dimensionless sediment rating curves (DSRCs) to accurately predict suspended-sediment concentrations (SSCs), bedload, and annual sediment loads for selected rivers and streams in Minnesota based on data collected during 2007 through 2013. (usgs.gov)
- A contract to evaluate LiDAR sensing technology to estimate dispersion distances of float coal dust and assess adequacies of rock dust coverage over large areas. (cdc.gov)

###### Phillips2

- Mankiw and Reis (2001a) have proposed a "sticky-information"-based Phillips curve (SIPC) to address some of the concerns with the "sticky-price"-based new Keynesian Phillips curve. (bankofcanada.ca)
- Recent research on the new Phillips curve (NPC) (e.g. (bankofcanada.ca)

###### COVID1

- Due to COVID and geographical challenges, GPS Trackit partnered with Learning Curve Consultants to determine the best way to deploy platform enhancements to over 4,000 customers. (lc-consultants.com)

###### Intuition1

- The underlying intuition behind the negatively sloped curve is that as vacancies (vacant job positions) increase, the number of people unemployed decreases. (europa.eu)

###### California1

- Governor Gavin Newsom reported that California is both stretching and flattening the curve, and the increases in case numbers are moderate rather than severe due to social distancing practices. (combatcovid.org)

###### Points2

- Choose a few data points on the x-axis under the curve (use a formula, if you have one) and list these values in Column A in sequence, starting from Row 1. (statisticshowto.com)
- Ensure that the first and last data points chosen on the curve are its starting and ending points respectively. (statisticshowto.com)

###### Left1

- If it begins to snow again while crews are working on residential streets, they go back to clearing the priority areas before picking back up where they left off in the residential area. (fortsask.ca)

###### Cody1

- Santa Clara County Health Officer Dr. Sara Cody claims that the Bay Area has averted a crisis, and although the disruption may last for a long time, everyone who needs care is receiving it. (combatcovid.org)

###### Decrease1

- along the curve, which reflects a decrease in market tightness. (europa.eu)

###### Estimate1

- What part a normally distributed random variable is some variability in tables to estimate of areas under a in both of where can use to vary by an accumulation starting from st. (givingtreeyoga.org)

###### Framework1

- In this article we look at the euro area labour market using the framework underlying the Beveridge curve, which captures the negative relationship between the unemployment rate and the job vacancy rate. (europa.eu)

###### Increases1

- The area under the curve decreases as the uncertainty of measurement of the diagnostic test increases [1]. (wolfram.com)

###### Flood2

###### Relation1

- The efficiency of the matching process, and thus the position of the Beveridge curve in relation to the origin, depends on a number of factors. (europa.eu)

###### Data9

- Simple and dependable data collection and estimation techniques are needed to generate hydraulic and water-quality information for areas where data are unavailable or difficult to collect. (usgs.gov)
- This is a very interesting topic, but it is still a method of data collection that is not much used in some areas. (researchgate.net)
- The data speeds were decent, but there are no 4G capabilities on the latest Curve. (brighthub.com)
- It's no suprise that the call quality, data and battery performance were decent as RIM seems to have that area well covered. (brighthub.com)
- Machine learning is an area of artificial intelligence research, which uses statistical methods for data classification. (hindawi.com)
- Use the Model tool to manually determine the curve of best fit for the data. (dummies.com)
- Using public historical data (IHS: 1907-2013) and applying the Creaming Curve method, it is possible to describe hydrocarbon potential in the Colombian productive basins. (searchanddiscovery.com)
- and with posterior data, with the use of data in loco in the study area. (usp.br)
- Another important area of focus is machine learning and data science. (feedburner.com)

###### Single1

- The Downtown San Diego Partnership, a downtown business group, counted a record 1,706 homeless residents staying downtown and areas just outside it on a single night last month. (voiceofsandiego.org)

###### Exam1

- By the cre exam called as a linux distribution of areas the table, x is certainly possible to another useful and whatnot in. (givingtreeyoga.org)

###### Versus2

- An ROC curve is a plot of the sensitivity of a test versus 1-specificity. (wolfram.com)
- The difference in the severity of the impacts between cities like New York and the Bay Area underscores the importance of enacting a proactive, versus a reactive, response. (combatcovid.org)

###### Cumulative2

###### Measurement1

- Uncertainty of Measurement and Areas Over and Under the ROC Curves' from the Wolfram Demonstrations Project-A Wolfram Web Resource. (wolfram.com)

###### Formal1

- Now we are ready to discuss the formal definition for the area under curves. (toppr.com)

###### America1

- Psychiatric disorders in America : the epidemiologic catchment area study / edited by Lee N. Robins and Darrell A. Regier. (who.int)

###### Method3

- Runoff curve numbers were calibrated for use in the Baseline Unit Hydrograph Method in Section 5600. (ku.edu)
- Improvements by Elkies and Atkin lead to an even faster method for elliptic curves, known as the SEA algorithm. (edu.au)
- Through the implementation of the Creaming Curve method, it is found that the potential of remaining reserves for Colombia are more than 1,624 MBbls and 457 wells are required to be drilled to achieve this potential. (searchanddiscovery.com)