Arbaprostil: A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and can inhibit the growth of experimental tumors.Prostaglandins E, Synthetic: Analogs or derivatives of prostaglandins E that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE.Gastric Acid: Hydrochloric acid present in GASTRIC JUICE.Purinergic P2Y Receptor Agonists: Compounds that bind to and stimulate PURINERGIC P2Y RECEPTORS. Included under this heading are agonists for specific P2Y receptor subtypes.Ultraviolet Rays: That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Keratinocytes: Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.Salts: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)Disaccharides: Oligosaccharides containing two monosaccharide units linked by a glycosidic bond.Nitroso CompoundsNitric Oxide: A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.Benzopyrans: Compounds with a core of fused benzo-pyran rings.Cromakalim: A potassium-channel opening vasodilator that has been investigated in the management of hypertension. It has also been tried in patients with asthma. (Martindale, The Extra Pharmacopoeia, 30th ed, p352)S-Nitrosothiols: A group of organic sulfur-containing nitrites, alkyl thionitrites. S-Nitrosothiols include compounds such as S-NITROSO-N-ACETYLPENICILLAMINE and S-NITROSOGLUTATHIONE.Nitrosation: Conversion into nitroso compounds. An example is the reaction of nitrites with amino compounds to form carcinogenic N-nitrosamines.Patents as Topic: Exclusive legal rights or privileges applied to inventions, plants, etc.Potassium Channels: Cell membrane glycoproteins that are selectively permeable to potassium ions. At least eight major groups of K channels exist and they are made up of dozens of different subunits.Prostaglandins: A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.Prostaglandins, Synthetic: Compounds obtained by chemical synthesis that are analogs or derivatives of naturally occurring prostaglandins and that have similar activity.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Alkenes: Unsaturated hydrocarbons of the type Cn-H2n, indicated by the suffix -ene. (Grant & Hackh's Chemical Dictionary, 5th ed, p408)Prostaglandins E: (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.Prostaglandins F, Synthetic: Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.Sodium Selenite: The disodium salt of selenious acid. It is used therapeutically to supply the trace element selenium and is prepared by the reaction of SELENIUM DIOXIDE with SODIUM HYDROXIDE.Selenium: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.Selenic Acid: A strong dibasic acid with the molecular formula H2SeO4. Included under this heading is the acid form, and inorganic salts of dihydrogen selenium tetraoxide.Selenium Compounds: Inorganic compounds that contain selenium as an integral part of the molecule.Yeast, Dried: The dry cells of any suitable strain of SACCHAROMYCES CEREVISIAE or CANDIDA. It can be obtained as a by-product from the brewing of beer or by growing on media not suitable for beer production. Dried yeast serves as a source of protein and VITAMIN B COMPLEX.Selenomethionine: Diagnostic aid in pancreas function determination.Selenious Acid: A selenium compound with the molecular formula H2SO3. It used as a source of SELENIUM, especially for patients that develop selenium deficiency following prolonged PARENTERAL NUTRITION.PhenylpropionatesSuprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It inhibits prostaglandin synthesis and has been proposed as an anti-arthritic.Platelet Aggregation: The attachment of PLATELETS to one another. This clumping together can be induced by a number of agents (e.g., THROMBIN; COLLAGEN) and is part of the mechanism leading to the formation of a THROMBUS.Blood Platelets: Non-nucleated disk-shaped cells formed in the megakaryocyte and found in the blood of all mammals. They are mainly involved in blood coagulation.Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.Epoprostenol: A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY).Carboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Zinc Compounds: Inorganic compounds that contain zinc as an integral part of the molecule.Inventions: A novel composition, device, or process, independently conceived de novo or derived from a pre-existing model.Methylene Chloride: A chlorinated hydrocarbon that has been used as an inhalation anesthetic and acts as a narcotic in high concentrations. Its primary use is as a solvent in manufacturing and food technology.Chlorides: Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.Oxalates: Derivatives of OXALIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that are derived from the ethanedioic acid structure.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Africa, Southern: The geographical area of Africa comprising ANGOLA; BOTSWANA; LESOTHO; MALAWI; MOZAMBIQUE; NAMIBIA; SOUTH AFRICA; SWAZILAND; ZAMBIA; and ZIMBABWE.Contactins: A family of immunoglobulin-related cell adhesion molecules that are involved in NERVOUS SYSTEM patterning.Consumer Health Information: Information intended for potential users of medical and healthcare services. There is an emphasis on self-care and preventive approaches as well as information for community-wide dissemination and use.Social Media: Platforms that provide the ability and tools to create and publish information accessed via the INTERNET. Generally these platforms have three characteristics with content user generated, high degree of interaction between creator and viewer, and easily integrated with other sites.Dissent and Disputes: Differences of opinion or disagreements that may arise, for example, between health professionals and patients or their families, or against a political regime.

Protective effects of arbaprostil against indomethacin-induced gastric lesions in rats: significance of maintained gastric blood flow. (1/6)

The purpose of the present study was to investigate the relationship between the effects of 15(R)-15-methylprostaglandin E2 (arbaprostil) on gastric blood flow (GBF) and its protective effects on gastric lesions in rats. The GBF of anesthetized rats was measured by two different methods: Total blood flow into the stomach (total GBF) was determined by means of an ultrasonic pulsed Doppler flow meter; and gastric mucosal blood flow (mucosal GBF) was measured by nonradioactive microspheres. Systemic blood pressure (SBP), heart rate (HR) and gastric vascular resistance (GVR) were recorded simultaneously. Arbaprostil (10-100 micrograms/kg) given i.v. did not affect resting total or mucosal GBF even though it decreased SBP and GVR. Significant improvement of the total and mucosal GBF decreased by indomethacin pretreatment (10 mg/kg, i.v.) was observed by administration of arbaprostil (10-100 micrograms/kg, i.v.) in a dose-dependent manner. Furthermore, i.v.-administration of this agent, in the same dose-range, prevented the formation of gastric lesions induced by indomethacin. The present result suggests that mitigation for the ischemic state of the gastric mucosa may be one of the important mechanisms for the prophylactic and curative effect of arbaprostil on gastric lesions induced by indomethacin.  (+info)

Acid-promoted epimerization of arbaprostil, 15(R)-15-methylprostaglandin E2, elicits gastric antisecretory activities in rats. (2/6)

Gastric acid antisecretory activities of 15(R)-15-methylprostaglandin E2 (arbaprostil) preincubated or not preincubated with 0.9% physiological saline, the pH of which was precisely adjusted to less than 4.30, were examined in pylorus-ligated rats, and compared with those of 15(S)-15-methylprostaglandin E2 (15(S), epimer of arbaprostil). 15(S), unlike arbaprostil without preincubation, when s.c.-administered to rats significantly inhibited gastric acid secretion in a dose-dependent manner (30-300 micrograms/kg). However, arbaprostil preincubated at 37 degrees C for 30 min with 0.9% saline, at pHs of 4.30, 2.75 and 1.20, respectively, showed the following order of pH-dependent antisecretory activities: 1.20 greater than 2.75 greater than 4.30. An increase in 15(S) formation from arbaprostil in a pH-dependent manner was also observed by radioisotopic experiments under the same incubation conditions using [3H]-labeled arbaprostil. The present result suggests that the gastric antisecretory effect of arbaprostil can be mainly explained in terms of the formation of 15(S) after oral administration.  (+info)

Gastric antisecretory activity of 15(R)-15-methylprostaglandin E2, arbaprostil, in dogs. (3/6)

The gastric antisecretory activity of 15(R)-15-methylprostaglandin E2 (arbaprostil) was compared with that of natural prostaglandin (PG) E2 in Pavlov pouch dogs. Arbaprostil significantly inhibited pentagastrin- and food-stimulated gastric secretion when it was administered directly into the pouch at a dose of 10-30 micrograms/pouch and 30-300 micrograms/pouch, respectively. Natural PGE2, however, was inactive up to 1000 micrograms/pouch. The data indicate that arbaprostil is a potent, long-acting orally active antisecretory drug that may be useful for the treatment of peptic ulcer disease.  (+info)

Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in rats. (4/6)

We studied the effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various acute and chronic gastric lesions produced in rats. Arbaprostil significantly inhibited gastric secretion in 4 hr-pylorus-ligated preparations when given intraduodenally in a dose of 30 or 100 micrograms/kg. The agent, however, significantly stimulated gastric secretion of rats with either a ligated or intact pylorus when given orally in doses of 3-100 micrograms/kg. Orally administered arbaprostil dose-dependently prevented the development of HCI-ethanol-, histamine-, water-immersion stress-, or indomethacin-induced gastric erosions. Intraduodenally administered arbaprostil also dose-dependently prevented the development of aspirin-induced gastric erosions in pylorus-ligated rats. Arbaprostil, given orally in doses of 1-100 micrograms/kg twice daily for 2 weeks, had little or no effect on the healing of acetic acid-induced gastric ulcers. However, oral administration of the agent in a dose of 3 or 10 micrograms/kg twice daily for 4 weeks significantly accelerated the healing of acetic acid-induced gastric ulcers. The increase in doses up to 100 micrograms/kg twice daily for 4 weeks had no effect on ulcer healing. These results indicate that arbaprostil, at either antisecretory or even acid stimulating doses, is effective in preventing the development of acute gastric erosions and in accelerating the healing of chronic gastric ulcers.  (+info)

Femtomole analysis of prostaglandin pharmaceuticals. (5/6)

An analytical method is described whereby the major classes of prostaglandins are fully resolved by microcolumn liquid chromatography and detected at the subfemtomole level by laser-induced fluorescence. The prostaglandins are labeled with the fluorescent reagent 4-bromo-methyl-7-methoxycoumarin and are subsequently separated on a high-efficiency fused-silica microcolumn (0.2 mm i.d., 1.06 m length, 150,000 theoretical plates). The optimal chromatographic conditions consist of a 3-micron octadecylsilica packing material and an isocratic mobile phase of 47.6% methanol, 23.8% acetonitrile, and 28.6% water. The prostaglandin derivatives are detected directly on the microcolumn by laser fluorimetry, using a helium/cadmium laser (325 nm, 15 mW) as the excitation source together with a simple filter/photo-multiplier optical detection system. In real sample matrices, the prostaglandin PGF2 alpha is readily quantifiable from the detection limit (0.3 fmol) to the formulation strength of the therapeutic agent Lutalyse (Upjohn), spanning more than six orders of magnitude in concentration. The simplicity and general applicability of the present analytical methodology and instrumentation suggest that this technique can be used to attack a wide variety of biomedically important problems with exceptional sensitivity and selectivity.  (+info)

Dose response inhibition in man of meal-stimulated gastric acid secretion by 15(R)-15-methyl prostaglandin E2, given orally. (6/6)

15(R)-15-methyl prostaglandin E2 was given orally to healthy male volunteers. Thirty minutes later a 10% peptone meal was introduced into the stomach, and the acid response was measured by continuous intragastric titration with 0.5 N NaOH for the next two hours. The prostaglandin inhibited acid output in a dose dependent manner; the ED50 (dose inhibiting acid output by 50%) was as little as 10 micrograms per subject (or approximately 140 ng/kg). This compound is the most potent orally active inhibitor of gastric acid secretion in man that is known. It is likely that the antisecretory and cytoprotective properties shared by 15(R)-15-methyl prostaglandin E2 would be beneficial in the treatment of peptic ulcer and in preventing recurrences.  (+info)

*Carboprost

Arbaprostil Bai, J; Sun, Q; Zhai, H (2014). "A comparison of oxytocin and carboprost tromethamine in the prevention of ...

*List of drugs: Aq-Ar

arbaclofen placarbil (USAN, INN) arbaprostil (INN) arbekacin (INN) arbutamine (INN) Arcalyst Arcet arcitumomab (INN) arclofenin ...

*List of MeSH codes (D10)

... arbaprostil MeSH D10.251.355.255.550.700.450.300 --- 16,16-dimethylprostaglandin e2 MeSH D10.251.355.255.550.700.450.350 --- ...

*List of MeSH codes (D23)

... arbaprostil MeSH D23.469.700.660.200 --- 16,16-dimethylprostaglandin e2 MeSH D23.469.700.660.250 --- enprostil MeSH D23.469. ...
BioAssay record AID 177813 submitted by ChEMBL: Compound was evaluated in vivo for the gastric antisecretory activity in the lumen perfused stomach of the anesthetized rat after iv administration.
WebMD explains some common complications of diabetes -- such as erectile dysfunction, vision problems, and infections -- so you can recognize the early warning signs.

Category:Carboxylic acids - Wikimedia CommonsCategory:Carboxylic acids - Wikimedia Commons

ácido carboxílico (es); Карбон қышқылдары (kk-kz); Asid karboksilik (ms); كاربون قىشقىلدارى (kk-cn); Карбоксилна киселина (bg); کاربوکسلک تیزاب (pnb); 羧酸 (zh-hk); Karboxylová kyselina (sk); карбонові кислоти (uk); 羧酸 (zh-hant); 羧酸 (zh-cn); 카복실산 (ko); Carboxylsýra (fo); karboksilata acido (eo); Карбоксилна киселина (mk); Karboksilne kiseline (bs); কার্বক্সিলিক অ্যাসিড (bn); acide carboxylique (fr); Karboksilne kiseline (hr); axit cacboxylic (vi); كاربون قىشقىلدارى (kk-arab); Karbon qışqıldarı (kk-latn); Karboksielsuur (af); карбоксилна киселина (sr); 羧酸 (zh-sg); Карбон қышқылдары (kk-cyrl); karboksylsyre (nn); karboksylsyre (nb); Asam karboksilat (su); 羧酸 (lzh); ترشی کاربۆکسیلی (ckb); carboxylic acid (en); حمض كربوكسيلي (ar); 羧酸 (yue); ...
more infohttps://commons.wikimedia.org/wiki/Category:Carboxylic_acids?uselang=de

Carboprost - WikipediaCarboprost - Wikipedia

Arbaprostil Bai, J; Sun, Q; Zhai, H (2014). "A comparison of oxytocin and carboprost tromethamine in the prevention of ...
more infohttps://en.wikipedia.org/wiki/Carboprost

Management of failed prostaglandin abortions.Management of failed prostaglandin abortions.

3914178 - Lack of effect of arbaprostil on the human non-pregnant uterus.. 9763058 - Pregnancy and homozygous beta thalassaemia ...
more infohttp://www.biomedsearch.com/nih/Management-failed-prostaglandin-abortions/943738.html

AceclofenacAceclofenac

... is a nonsteroidal anti-inflammatory drug (NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. Aceclofenac (C16H13Cl2NO4), chemically [(2-{2, 6-dichlorophenyl) amino} phenylacetooxyacetic acid], is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form [2-(2,6-dichloro-4-hydroxy- phenylamino) phenyl] acetoxyacetic acid as the major metabolite, which is then further conjugated. According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability. Aceclofenac falls under the BCS Class II, poorly soluble and highly permeable drug.[1] Aceclofenac works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandins (PG) which is accountable for ...
more infohttps://readtiger.com/wkp/en/Aceclofenac

Anti-ulcerative agents; TerraQSAR-LOGP computed octanol/water partition coefficients (CLOGPs)Anti-ulcerative agents; TerraQSAR-LOGP computed octanol/water partition coefficients (CLOGPs)

arbaprostil 55028-70-1 C21H34O5 366.50 7.10 rioprostil 77287-05-9 C21H38O4 354.53 7.09 lafutidine 118288-08-7 C22H29N3O4S ...
more infohttp://terrabase-inc.com/anti-ulceratives.html

Methyl salicylateMethyl salicylate

In pure form, methyl salicylate is harmful, when taken orally. A single teaspoon (5 ml) of methyl salicylate contains approximately 6 g of salicylate,[19] which is equivalent to almost twenty 300 mg aspirin tablets (5 mL * 1.174 g/mL = 5.87 g). The lowest published lethal dose is 101 mg/kg body weight in adult humans,[20] (or 7.07 grams for a 70-kg adult). It has proven fatal to small children in doses as small as 4 ml.[10] A seventeen-year-old cross-country runner at Notre Dame Academy on Staten Island died in April 2007 after her body absorbed methyl salicylate through excessive use of topical muscle-pain relief products.[21]. Most instances of human toxicity due to methyl salicylate are a result of over-application of topical analgesics, especially involving children. Some people have intentionally ingested large amounts of oil of wintergreen. Salicylate, the major metabolite of methyl salicylate, may be quantitated in blood, plasma or serum to confirm a diagnosis of poisoning in hospitalized ...
more infohttps://ipfs.io/ipfs/QmXoypizjW3WknFiJnKLwHCnL72vedxjQkDDP1mXWo6uco/wiki/Methyl_salicylate.html

RetinoidRetinoid

The major source of retinoids from the diet are plant pigments such as carotenes and retinyl esters derived from animal sources. Retinyl esters are hydrolyzed in the intestinal lumen to yield free retinol and the corresponding fatty acid (i.e. palmitate or stearate). After hydrolysis, retinol is taken up by the enterocytes. Retinyl ester hydrolysis requires the presence of bile salts that serve to solubilize the retinyl esters in mixed micelles and to activate the hydrolyzing enzymes [3]. Several enzymes that are present in the intestinal lumen may be involved in the hydrolysis of dietary retinyl esters. Cholesterol esterase is secreted into the intestinal lumen from the pancreas and has been shown, in vitro, to display retinyl ester hydrolase activity. In addition, a retinyl ester hydrolase that is intrinsic to the brush-border membrane of the small intestine has been characterized in the rat as well as in the human. The different hydrolyzing enzymes are activated by different types of bile ...
more infohttp://library.kiwix.org/wikipedia_en_all_nopic_2018-09/A/Retinoid.html

FluproquazoneFluproquazone

Lewis JH and Stine JG. Nonsteroidal Antiinflammatory Drugs and Leukotriene Receptor Antagonists, Ch 22 in Drug-induced Liver Disease (Third Edition). Eds Neil Kaplowitz and Laurie D. DeLeve. Elsevier Inc, 2013. ISBN 9780123878175 ...
more infohttps://ipfs.io/ipfs/QmXoypizjW3WknFiJnKLwHCnL72vedxjQkDDP1mXWo6uco/wiki/Fluproquazone.html

Patent US6693122 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google PatentsPatent US6693122 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patents

... arbaprostil, unoprostone, trimoprostil, carboprost, limaprost, gemeprost, lantanoprost, ornoprostil, beraprost, sulpostrone, ...
more infohttp://www.google.com/patents/US6693122?dq=6978253

Patente US20020143188 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google PatentesPatente US20020143188 - Nitrosated and nitrosylated potassium channel activators, compositions and ... - Google Patentes

... arbaprostil, unoprostone, trimoprostil, carboprost, limaprost, gemeprost, lantanoprost, ornoprostil, beraprost, sulpostrone, ...
more infohttp://www.google.es/patents/US20020143188

研究者情報

       - 岡本 専太郎

       | 神奈川大学研究者情報 - 岡本 専太郎 | 神奈川大学

Synthesis of Arbaprostil (共著) 1991 126. 論文 Highly Efficient Synthesis of 13-Dehydroprostaglandins by 1,4-Addition Reaction of ...
more infohttps://kenkyu.kanagawa-u.ac.jp/kuhp/KgApp?kyoinId=ymiygiomggg

Application # 2005/0002865. Diagnostic/therapeutic agents - Patents.comApplication # 2005/0002865. Diagnostic/therapeutic agents - Patents.com

... arbaprostil, arbekacin, arclofenin, arfendazam, arginine, arginine glutamat, arildone, arnolol, aronixil, arotinolol, arpinocid ...
more infohttp://www.patents.com/us-20050002865.html

Application # 2016/0237056. NOVEL SYNTHESIS ROUTES FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES
     USING METATHESIS -...Application # 2016/0237056. NOVEL SYNTHESIS ROUTES FOR PROSTAGLANDINS AND PROSTAGLANDIN INTERMEDIATES USING METATHESIS -...

... arbaprostil, enisoprost, mexiprostil, dimoxaprost, tiprostanide, and remiprostol as well as other prostaglandin analogues in ...
more infohttp://patents.com/us-20160237056.html

Original Drugstore: When does viagra come off of patent the highest quality!Original Drugstore: When does viagra come off of patent the highest quality!

In primary agent (atropine sulphate), used as the ribs are pge2 (enprostil, arbaprostil, rioprostil), given alone. Those ...
more infohttps://rainierfruit.com/when-does-viagra-come-off-of-patent/

List of drugs: Aq-Ar - WikipediaList of drugs: Aq-Ar - Wikipedia

arbaclofen placarbil (USAN, INN) arbaprostil (INN) arbekacin (INN) arbutamine (INN) Arcalyst Arcet arcitumomab (INN) arclofenin ...
more infohttps://en.wikipedia.org/wiki/List_of_drugs:_Aq-Ar

Journal of Food Hygiene and SafetyJournal of Food Hygiene and Safety

1986) Effects of 15(R)-15-methyl prostaglandin E2 (arbaprostil) on gastric secretion and various gastric lesions induced in ...
more infohttp://foodsafety.or.kr/journal/article.php?code=57941

Selexipag - WikipediaSelexipag - Wikipedia

InChI=1S/C26H32N4O4S/c1-20(2)30(16-10-11-17-34-19-24(31)29-35(3,32)33)23-18-27-25(21-12-6-4-7-13-21)26(28-23)22-14-8-5-9-15-22/h4-9,12-15,18,20H,10-11,16-17,19H2,1-3H3,(H,29,31) ...
more infohttps://en.wikipedia.org/wiki/Selexipag

Mesalazine - WikipediaMesalazine - Wikipedia

Mesalazine, also known as mesalamine or 5-aminosalicylic acid (5-ASA), is a medication used to treat inflammatory bowel disease, including ulcerative colitis and Crohns disease.[2] It is generally used for mildly to moderately severe disease.[2] It is taken by mouth or rectally.[2] The formulations which are taken by mouth appear to be similarly effective.[3] Common side effects include headache, nausea, abdominal pain, and fever.[2] Serious side effects may include pericarditis, liver problems, and kidney problems.[2][3] Use in pregnancy and breastfeeding appears safe.[3] In people with a sulfa allergy certain formulations may result in problems.[2] Mesalazine is an aminosalicylate and anti-inflammatory.[2][3] It works by direct contact with the intestines.[2] Mesalazine was approved for medical use in the United States in 1987.[2][4] It is available as a generic medication and sold under many brand names worldwide.[5][2] A month supply in the United Kingdom costs the NHS about £43 as of ...
more infohttps://en.wikipedia.org/wiki/Asacol

View the content page [c]View the content page [c]

Together with the related barium and zinc selenites, sodium selenite is mainly used in the manufacture of colorless glass. The pink color imparted by these selenites cancels out the green color imparted by iron impurities.[3] Because selenium is an essential element, sodium selenite is an ingredient in dietary supplements such as multi-vitamin/mineral products, but supplements that provide only selenium use L-selenomethionine or a selenium-enriched yeast. The US Food and Drug Administration approved a selenium supplement to animal diets; the most common form is sodium selenite for pet foods. According to one article, "not much was known about which selenium compounds to approve for use in animal feeds when the decisions were made back in the 1970s .. At the time the regulatory action was taken, only the inorganic selenium salts (sodium selenite and sodium selenate) were available at a cost permitting their use in animal feed." [4] ...
more infohttp://www.let.rug.nl/~gosse/termpedia2/termpedia.php?language=dutch_general&density=7&link_color=000000&termpedia_system=perl_db&url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FSodium_selenite

View the content page [c]View the content page [c]

Mikashima, H.; Goto, K. (Jan 1982). "[Inhibitory effect of 2-(4-(2-imidazo(1,2-a)pyridyl)phenyl) propionic acid (miroprofen) on platelet aggregation and prostaglandin I2 generation (authors transl)]". Yakugaku Zasshi. 102 (1): 99-103. PMID 7045328 ...
more infohttp://www.let.rug.nl/~gosse/termpedia2/termpedia.php?language=dutch_general&density=7&link_color=000000&termpedia_system=perl_db&url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FMiroprofen

Indian Patents. 207623:PHARMACEUTICAL COMPOUNDSIndian Patents. 207623:PHARMACEUTICAL COMPOUNDS

for antiulcer drugs the following can be mentioned: acetamidocaproic acid, arbaprostil, cetraxate, cimetidine, ecabet, ...
more infohttp://www.allindianpatents.com/patents/207623-pharmaceutical-compounds

Nitric Oxide Releasing Produgs of Therapeutic Agents - Patent applicationNitric Oxide Releasing Produgs of Therapeutic Agents - Patent application

... arbaprostil, carbenoxolone, cetraxate, ecabet, S-methylmethionine, proglumide, rebamipide, rosaprostol, rotraxate, sofalcone ... arbaprostil, carbenoxolone, cetraxate, ecabet, S-methylmethionine, proglumide, rebamipide, rosaprostol, rotraxate, sofalcone ...
more infohttp://www.patentsencyclopedia.com/app/20150328323

ORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN II ANTAGONISTS, COMPOSITIONS AND METHODS OF USE - Patent applicationORGANIC NITRIC OXIDE ENHANCING SALTS OF ANGIOTENSIN II ANTAGONISTS, COMPOSITIONS AND METHODS OF USE - Patent application

... arbaprostil, alprostadil, beraprost, carboprost, cloprostenol, dimoxaprost, enprostil, enisoprost, fluprostenol, fenprostalene ...
more infohttp://www.patentsencyclopedia.com/app/20090215838

WhatLinksHere Definition and Examples | Biology Online DictionaryWhatLinksHere Definition and Examples | Biology Online Dictionary

Arbaprostil ‎ (← links). *Allatostatin ‎ (← links). *Carbonic acid inhibitor ‎ (← links). *Tissue-inhibitor of ...
more infohttps://www.biology-online.org/dictionary/index.php?title=Special:WhatLinksHere&target=Inhibit

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