Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Phosphodiesterase 4 Inhibitors: Compounds that specifically inhibit PHOSPHODIESTERASE 4.CyclopropanesAminopyridines: Pyridines substituted in any position with an amino group. May be hydrogenated, but must retain at least one double bond.Pulmonary Disease, Chronic Obstructive: A disease of chronic diffuse irreversible airflow obstruction. Subcategories of COPD include CHRONIC BRONCHITIS and PULMONARY EMPHYSEMA.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Urinary Tract Infections: Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.Bronchitis, Chronic: A subcategory of CHRONIC OBSTRUCTIVE PULMONARY DISEASE. The disease is characterized by hypersecretion of mucus accompanied by a chronic (more than 3 months in 2 consecutive years) productive cough. Infectious agents are a major cause of chronic bronchitis.Bronchitis: Inflammation of the large airways in the lung including any part of the BRONCHI, from the PRIMARY BRONCHI to the TERTIARY BRONCHI.Annexin A4: Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.Coronary Vessel Anomalies: Malformations of CORONARY VESSELS, either arteries or veins. Included are anomalous origins of coronary arteries; ARTERIOVENOUS FISTULA; CORONARY ANEURYSM; MYOCARDIAL BRIDGING; and others.Morphogenesis: The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.Methyltransferases: A subclass of enzymes of the transferase class that catalyze the transfer of a methyl group from one compound to another. (Dorland, 28th ed) EC 2.1.1.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Lysine: An essential amino acid. It is often added to animal feed.Histones: Small chromosomal proteins (approx 12-20 kD) possessing an open, unfolded structure and attached to the DNA in cell nuclei by ionic linkages. Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Gynostemma: A plant genus of the family CUCURBITACEAE. It is a source of gypenosides and triterpenoid SAPONINS.RomaniaOchromonas: A genus of GOLDEN-BROWN ALGAE in the family Ochromonadaceae, found mostly in freshwater. They bear two unequal FLAGELLA and are heterotrophic.Eukaryota: One of the three domains of life (the others being BACTERIA and ARCHAEA), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including ANIMALS; PLANTS; FUNGI; and various algae and other taxa that were previously part of the old kingdom Protista.Chrysophyta: A family of microscopic freshwater EUKARYOTA, commonly known as golden algae. They share many features with the BROWN ALGAE but are planktonic rather than benthic. Though most are photosynthetic, they are not considered truly autotrophic since they can become facultatively heterotrophic in the absence of adequate light. In this state they can feed on BACTERIA or DIATOMS.Europe, EasternTick Bites: The effects, both local and systemic, caused by the bites of TICKS.BulgariaSlovakia: Created 1 January 1993 as a result of the division of Czechoslovakia into the Czech Republic and Slovakia.

Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity. (1/691)

We previously reported that the role of reactive oxygen intermediates (ROIs) in NF-kappaB activation by proinflammatory cytokines was cell specific. However, the sources for ROIs in various cell types are yet to be determined and might include 5-lipoxygenase (5-LOX) and NADPH oxidase. 5-LOX and 5-LOX activating protein (FLAP) are coexpressed in lymphoid cells but not in monocytic or epithelial cells. Stimulation of lymphoid cells with interleukin-1beta (IL-1beta) led to ROI production and NF-kappaB activation, which could both be blocked by antioxidants or FLAP inhibitors, confirming that 5-LOX was the source of ROIs and was required for NF-kappaB activation in these cells. IL-1beta stimulation of epithelial cells did not generate any ROIs and NF-kappaB induction was not influenced by 5-LOX inhibitors. However, reintroduction of a functional 5-LOX system in these cells allowed ROI production and 5-LOX-dependent NF-kappaB activation. In monocytic cells, IL-1beta treatment led to a production of ROIs which is independent of the 5-LOX enzyme but requires the NADPH oxidase activity. This pathway involves the Rac1 and Cdc42 GTPases, two enzymes which are not required for NF-kappaB activation by IL-1beta in epithelial cells. In conclusion, three different cell-specific pathways lead to NF-kappaB activation by IL-1beta: a pathway dependent on ROI production by 5-LOX in lymphoid cells, an ROI- and 5-LOX-independent pathway in epithelial cells, and a pathway requiring ROI production by NADPH oxidase in monocytic cells.  (+info)

Interaction of 5-lipoxygenase with cellular proteins. (2/691)

5-Lipoxygenase (5LO) plays a pivotal role in cellular leukotriene synthesis. To identify proteins interacting with human 5LO, we used a two-hybrid approach to screen a human lung cDNA library. From a total of 1.5 x 10(7) yeast transformants, nine independent clones representing three different proteins were isolated and found to specifically interact with 5LO. Four 1.7- to 1.8-kb clones represented a 16-kDa protein named coactosin-like protein for its significant homology with coactosin, a protein found to be associated with actin in Dictyostelium discoideum. Coactosin-like protein thus may provide a link between 5LO and the cytoskeleton. Two other yeast clones of 1.5 kb encoded transforming growth factor (TGF) type beta receptor-I-associated protein 1 partial cDNA. TGF type beta receptor-I-associated protein 1 recently has been reported to associate with the activated form of the TGF beta receptor I and may be involved in the TGF beta-induced up-regulation of 5LO expression and activity observed in HL-60 and Mono Mac 6 cells. Finally, three identical 2.1-kb clones contained the partial cDNA of a human protein with high homology to a hypothetical helicase K12H4. 8 from Caenorhabditis elegans and consequently was named DeltaK12H4. 8 homologue. Analysis of the predicted amino acid sequence revealed the presence of a RNase III motif and a double-stranded RNA binding domain, indicative of a protein of nuclear origin. The identification of these 5LO-interacting proteins provides additional approaches to studies of the cellular functions of 5LO.  (+info)

Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells. (3/691)

The mouse leukotriene B4 receptor (m-BLTR) gene was cloned. Membrane fractions of human embryonic kidney 293 cells stably expressing m-BLTR demonstrated a high affinity and specific binding for leukotriene B4 (LTB4, Kd = 0.24 +/- 0.03 nM). In competition binding experiments, LTB4 was the most potent competitor (Ki = 0.23 +/- 0.05 nM) followed by 20-hydroxy-LTB4 (Ki = 1.1 +/- 0.2 nM) and by 6-trans-12-epi-LTB4 and LTD4 (Ki > 1 microM). In stably transfected Chinese hamster ovary cells, LTB4 inhibited forskolin-activated cAMP production and induced an increase of intracellular calcium, suggesting that this receptor is coupled to Gi- and Go-like proteins. In Xenopus laevis melanophores transiently expressing m-BLTR, LTB4 induced the aggregation of pigment granules, confirming the inhibition of cAMP production induced by LTB4. BLT receptors share significant sequence homology with chemokine receptors (CCR5 and CXCR4) that act as human immunodeficiency virus (HIV) coreceptors. However, among the 16 HIV/SIV strains tested, the human BLT receptor did not act as a coreceptor for virus entry into CD4-expressing cells based on infection and cell-cell fusion assays. In 5-lipoxygenase-deficient mice, the absence of leukotriene B4 biosynthesis did not detectably alter m-BLT receptor binding in membranes obtained from glycogen-elicited neutrophils. Isolation of the m-BLTR gene will form the basis of future experiments to elucidate the selective role of LTB4, as opposed to cysteinyl-leukotrienes, in murine models of inflammation.  (+info)

Pneumococcus activation of the 5-lipoxygenase pathway and production of glycoproteins in the middle ear of rats. (4/691)

Pneumococcal otitis media is associated with the production of potent inflammatory mediators (leukotrienes), but the mechanism by which pneumococcus induces production of leukotrienes in the middle ear is poorly understood. In this study, up-regulation of 2 genes that govern the lipoxygenase pathway, cPLA2 and 5-LOX, was observed in rats following inoculation of pneumococcus into the middle ear cavity. Expression of cPLA2 was low, and 5-LOX gene expression was not detected in control animals. Up-regulation of cPLA2 and 5-LOX in middle ear epithelial cells was accompanied by an increase of high-molecular-weight glycoproteins in middle ear fluid and cells. These findings suggest that pneumococcus activates the lipoxygenase pathway by up-regulating expression of the cPLA2 and 5-LOX genes. This, in turn, may stimulate synthesis and secretion of high-molecular-weight glycoproteins that facilitate production of fluid in the middle ear cleft.  (+info)

Leukotriene A synthase activity of purified mouse skin arachidonate 8-lipoxygenase expressed in Escherichia coli. (5/691)

Mouse skin 8-lipoxygenase was expressed in COS-7 cells by transient transfection of its cDNA in pEF-BOS carrying an elongation factor-1alpha promoter. When crude extract of the transfected COS-7 cells was incubated with arachidonic acid, 8-hydroxy-5,9,11, 14-eicosatetraenoic acid was produced as assessed by reverse- and straight-phase high performance liquid chromatographies. The recombinant enzyme also reacted on alpha-linolenic and docosahexaenoic acids at almost the same rate as that with arachidonic acid. Eicosapentaenoic and gamma-linolenic acids were also oxygenated at 43% and 56% reaction rates of arachidonic acid, respectively. In contrast, linoleic acid was a poor substrate for this enzyme. The 8-lipoxygenase reaction with these fatty acids proceeded almost linearly for 40 min. The 8-lipoxygenase was also expressed in an Escherichia coli system using pQE-32 carrying six histidine residues at N-terminal of the enzyme. The expressed enzyme was purified over 380-fold giving a specific activity of approximately 0.2 micromol/45 min per mg protein by nickel-nitrilotriacetate affinity chromatography. The enzymatic properties of the purified 8-lipoxygenase were essentially the same as those of the enzyme expressed in COS-7 cells. When the purified 8-lipoxygenase was incubated with 5-hydroperoxy-6,8,11, 14-eicosatetraenoic acid, two epimers of 6-trans-leukotriene B4, degradation products of unstable leukotriene A4, were observed upon high performance liquid chromatography. Thus, the 8-lipoxygenase catalyzed synthesis of leukotriene A4 from 5-hydroperoxy fatty acid. Reaction rate of the leukotriene A synthase was approximately 7% of arachidonate 8-lipoxygenation. In contrast to the linear time course of 8-lipoxygenase reaction with arachidonic acid, leukotriene A synthase activity leveled off within 10 min, indicating suicide inactivation.  (+info)

Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone marrow-derived mast cells. (6/691)

We have used mice in which the gene for cytosolic phospholipase A2 (cPLA2) has been disrupted to demonstrate the absolute requirement for cPLA2 in both the immediate and the delayed phases of eicosanoid generation by bone marrow-derived mast cells. For the immediate phase, quantitative analysis of the products of the 5-lipoxygenase pathway showed that gene disruption of cPLA2 prevented the provision of arachidonic acid substrate for biosynthesis of proximal intermediates. By analogy, we conclude that arachidonic acid substrate was also not available to prostaglandin endoperoxide synthase 1 in the immediate phase of prostaglandin (PG) D2 generation. These defects occurred with two distinct stimuli, stem cell factor and IgE/antigen, which were, however, sufficient for signal transduction defined by exocytosis of beta-hexosaminidase. Whereas cPLA2 is essential for immediate eicosanoid generation by providing arachidonic acid, its role in delayed-phase PGD2 generation is more complex and involves the activation-dependent induction of prostaglandin endoperoxide synthase 2 and the supply of arachidonic acid for metabolism to PGD2.  (+info)

Relationship of arachidonic acid metabolizing enzyme expression in epithelial cancer cell lines to the growth effect of selective biochemical inhibitors. (7/691)

Arachidonic acid (AA) metabolizing enzymes are emerging as significant mediators of growth stimulation for epithelial cells. The relative contribution of the various family members of AA metabolizing enzymes to epithelial cancer cell growth is not known. To study this question, we first analyzed a series of epithelial cancer cells to establish the relative frequency of expression for the various enzymes. We analyzed the expression of five AA metabolizing enzymes as well as 5-lipoxygenase activating protein (FLAP) in a panel of human epithelial cancer cell lines (n = 20) using reverse transcription-PCR. From this analysis, we found that cyclooxygenase-1 (COX-1), 5-lipoxygenase (5-LOX), and FLAP were universally expressed in all cancer cell lines tested. For the remaining enzymes, the expression of COX-2, 12-LOX, and 15-LOX varied among cell lines, 60, 35, and 90%, respectively. Although the pattern of expression varied among the different cell types, all of the enzymes were expressed in all major cancer histologies. Using a panel of selective biochemical AA metabolizing enzyme inhibitors, we then evaluated the effect of these agents on cell lines with known expression status for the AA metabolizing enzymes. For the enzymes that were not universally expressed, growth inhibition by selective biochemical inhibitors did not closely correlate with the expression status of specific enzymes (P > 0.05). For the universally expressed enzymes, the LOX inhibitors were more potent growth inhibitors than the COX inhibitors. The frequent expression of the AA metabolizing enzymes suggests that AA metabolism pathway may be modulated in response to xenobiotic exposure during carcinogenesis. Although establishing a priori AA metabolizing enzyme status was not consistently informative about what AA metabolizing enzyme inhibition would be most growth inhibitory, the frequent inhibition of many epithelial cancers by these biochemical inhibitors opens a new avenue for cancer therapy and intervention in carcinogenesis.  (+info)

Gene expression of 5-lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients. (8/691)

Leukotrienes (LT) of the 5-lipoxygenase pathway constitute a class of potent biological lipid mediators of inflammation implicated in the pathogenesis of different models of experimental glomerulonephritis. The key enzyme, 5-lipoxygenase (5-LO), catalyses oxygenation of arachidonic acid to generate the primary leukotriene LTA4. This LT, in turn, serves as a substrate for either LTA4 hydrolase, to form the potent chemoattractant LTB4, or LTC4 synthase, to produce the powerful vasoconstrictor LTC4. To investigate the potential role of LT in the pathogenesis of human glomerulonephritis with nephrotic syndrome, we examined the gene expression of 5-LO and LTA4 hydrolase in renal tissue of 21 adult patients with nephrotic syndrome and 11 controls. The patients consisted of 11 cases of membranous nephropathy (MN), seven focal and segmental glomerulosclerosis (FSGS), two non-IgA mesangial glomerulonephritis and one minimal change disease. Total RNA purified from renal tissue was reverse transcribed into cDNA and amplified with specific primers in a polymerase chain reaction (RT-PCR). Eight patients' renal tissue, four MN and four FSGS, co-expressed 5-LO and LTA4 hydrolase. In situ hybridization analysis revealed 5-LO expression and distribution limited to the interstitial cells surrounding the peritubular capillaries. Comparative clinical and immunohistological data showed that these eight patients had impaired renal function and interstitial changes that significantly correlated with 5-LO expression. These findings suggest that leukotrienes may play an important role in the pathogenesis of MN and FSGS. These results are also relevant to elucidating the pathophysiologic mechanisms which underlie progression to renal failure in these diseases.  (+info)

*Arachidonate 5-lipoxygenase

... , also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... "Alox5 - arachidonate 5-lipoxygenase". WikiGenes. Fahel JS, de Souza MB, Gomes MT, Corsetti PP, Carvalho NB, Marinho FA, de ... Arachidonate 5-lipoxygenase is a member of the lipoxygenase family of enzymes. It transforms essential fatty acids (EFA) ... Arachidonate 5-Lipoxygenase at the US National Library of Medicine Medical Subject Headings (MeSH) Human ALOX5 genome location ...

*Arachidonate 5-lipoxygenase inhibitor

Lipoxygenase inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82016859. ... Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5- ... lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of ... Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a ...

*Hypericum perforatum

In humans, the active ingredient hyperforin is also an inhibitor of PTGS1, arachidonate 5-lipoxygenase, SLCO1B1 and an inducer ... It is a medicinal herb with antidepressant activity and anti-inflammatory properties as an arachidonate 5-lipoxygenase ... Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a ... 2002;325:781-5. Kumar V, Mdzinarishvili A, Kiewert C, Abbruscato T, Bickel U, van der Schyf CJ, Klein J (2006). "NMDA receptor- ...

*Antileukotriene

An antileukotriene is a drug which functions as a leukotriene-related enzyme inhibitor (arachidonate 5-lipoxygenase) or ... "Inhibition of five lipoxygenase activating protein (FLAP) by MK-886 decreases atherosclerosis in apoE/LDLR-double knockout mice ... Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a ... Examples of 5-LOX inhibitors include drugs, such as meclofenamate sodium and zileuton. Some chemicals found in trace amounts in ...

*Eicosanoid

ALOX12B (i.e. arachidonate 12-lipoxygenase, 12R type) forms R chirality products, i.e. 12R-HpETE and 12R-HETE. Similarly, ... The enzymes 15-lipoxygenase-1 (15-LO-1 or ALOX15) and 15-lipoxygenase-2 (15-LO-2, ALOX15B) metabolize arachidonic acid to the S ... Other reactions of lipoxygenases generate cellular damage; murine models implicate 15-lipoxygenase in the pathogenesis of ... The enzyme arachidonate 12-lipoxygenase (12-LO or ALOX12) metabolizes arachidonic acid to the S stereoisomer of 12- ...

*Prostate cancer

Arachidonate 5-lipoxygenase has been identified as playing a significant role in the survival of prostate cancer cells. ... In particular, arachidonate 5-lipoxygenase inhibitors produce massive, rapid programmed cell death in prostate cancer cells. ... Ghosh J, Myers CE (October 1998). "Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate ... The 5-year survival rate in the United States is 99%. Globally it is the second most common type of cancer and the fifth ...

*Leukotriene

... s are synthesized in the cell from arachidonic acid by arachidonate 5-lipoxygenase. The catalytic mechanism involves ... The lipoxygenase pathway is active in leukocytes and other immunocompetent cells, including mast cells, eosinophils, ... by the enzyme arachidonate 5-lipoxygenase. Leukotrienes use lipid signaling to convey information to either the cell producing ... 5-HETE can be further metabolized to 5-oxo-ETE and 5-oxo-15-hydroxy-ETE, all of which have pro-inflammatory actions similar but ...

*5-lipoxygenase-activating protein

Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in ... Tsai AK, Li N, Hanson NQ, Tsai MY, Tang W (December 2009). "Associations of genetic polymorphisms of arachidonate 5- ... Zintzaras E, Rodopoulou P, Sakellaridis N (March 2009). "Variants of the arachidonate 5-lipoxygenase-activating protein ( ... lipoxygenase-activating protein with risk of coronary artery disease in a European-American population". Atherosclerosis. 207 ( ...

*Oxoeicosanoid receptor 1

Hussey HJ, Tisdale MJ (1996). "Inhibition of tumour growth by lipoxygenase inhibitors". Br. J. Cancer. 74 (5): 683-687. doi: ... Ghosh J, Myers CE (1998). "Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells ... Ding XZ, Iversen P, Cluck MW, Knezetic JA, Adrian TE (1999). "Lipoxygenase inhibitors abolish proliferation of human pancreatic ... mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells". Cancer Lett. 336 (1): 185-95 ...

*Perovskia atriplicifolia

The isorinic acid derivative perovskoate may also contribute to an anti-inflammatory effect as an arachidonate 5-lipoxygenase ... They are generally 3-5 cm long (1.2-2.0-inch) and 0.8-2 cm wide (0.3-0.8-inch), although narrower in some populations. The ... 4-5. Missouri Botanical Garden (b). Missouri Botanical Garden (c). Missouri Botanical Garden (d). Hedge 1990, p. 221. Keys & ... 2, 5. Proctor 1999, p. 107. Burrell 2002, p. 53. Mani 1978, p. 113. Curtis's Botanical Magazine 1912. Tareen & Qadir 1991, p. ...

*Eoxin

The primary product of the lipoxygenase, 15-HPETE is believed to react with the enzyme further to produce the 14,15-epoxide, ... Arachidonate 5-lipoxygenase Arachidonate 15-lipoxygenase Leukotriene 15-Hydroxyicosatetraenoic acid Greene ER, Huang S, Serhan ... Claesson HE (September 2009). "On the biosynthesis and biological role of eoxins and 15-lipoxygenase-1 in airway inflammation ... Forsell PK, Brunnström A, Johannesson M, Claesson HE (2012). "Metabolism of anandamide into eoxamides by 15-lipoxygenase-1 and ...

*Gamma-Linolenic acid

When acting on GLA, Arachidonate 5-lipoxygenase produces no leukotrienes and the conversion by the enzyme of arachidonic acid ... 16 (5): 279-282. Archived from the original (PDF) on 2014-01-12. Nasaruddin, Mohd hanif; Noor, Noor Qhairul Izzreen Mohd; Mamat ... 57 (5 Suppl): 732S-736S; discussion 736S-737S. PMID 8386433. King, Michael W. "Introduction to the Eicosanoids". The Medical ... doi:10.1007/s11248-011-9543-5. PMID 21853296. Flider, Frank J (May 2005). "GLA: Uses and New Sources" (PDF). INFORM. ...

*Curcumin

... and the arachidonate 5-lipoxygenase enzyme. Factors that limit the bioactivity of curcumin or its analogs include chemical ... 59 (5): 1671-1690. doi:10.1021/acs.jmedchem.5b01009. ISSN 0022-2623. PMC 4791574 . PMID 26505758. Reuter, S.; Gupta, S. C.; ... 60 (5): 1620-1637. doi:10.1021/acs.jmedchem.6b00975. PMC 5346970 . PMID 28074653. Vogel, H.; Pelletier, J. (1815). "Curcumin - ... The first mechanism involves a chain extension reaction by cinnamic acid and 5 malonyl-CoA molecules that eventually arylized ...

*5-oxo-eicosatetraenoic acid

First, human eosinophils use Arachidonate 15-lipoxygenase-1 (or possibly Arachidonate 15-lipoxygenase-2 to metabolize 5-oxo-ETE ... Second, human platelets use 12-lipoxygenase to metabolize 5-oxo-ETE to 5-oxo-12(S)-hydroperxy-eicosatetraenoat which is rapidly ... and lipoxygenase-derived eicosanoids". Drug Metabolism and Disposition. 39 (2): 180-90. doi:10.1124/dmd.110.035121. PMC 3033693 ... oxygenation of this arachidonic acid with by activated arachidonate 5-lipoxygenase (ALOX5) to form 5(S)-hydroperoxy-6E,8Z,11Z, ...

*List of MeSH codes (D12.776)

... lipoxygenase MeSH D12.776.556.579.374.450.025 - arachidonate lipoxygenases MeSH D12.776.556.579.374.450.025.020 - arachidonate ... arachidonate 12-lipoxygenase MeSH D12.776.556.579.374.450.025.030 - arachidonate 15-lipoxygenase MeSH D12.776.556.579.374.687 ... cyclin-dependent kinase 5 MeSH D12.776.167.200.067.900 - cyclin-dependent kinase 9 MeSH D12.776.167.200.580.500 - cdc2 protein ... myogenic regulatory factor 5 MeSH D12.776.210.500.570.600 - myogenin MeSH D12.776.210.500.600.100 - myosin heavy chains MeSH ...

*5-Hydroxyeicosanoid dehydrogenase

... is an enzyme that metabolizes an eicosanoid product of arachidonate 5-lipoxygenase (5-LOX), 5(S)-hydroxy-6S,8Z,11Z,14Z- ... Since 5-oxo-ETE is 30-100-fold more potent than 5(S)-HETE in stimulating various cell types, 5-HEDH is regarded as a regulator ... 5-HEDH functions as a highly specific oxidizer of 5(S)-HETE to 5-oxo-ETE; no functional importance has yet been ascribed to its ... Although 5-HEDH has been evaluated in a wide range of intact cells and in crude microsome preparations, it has not yet been ...

*5-Hydroxyeicosatetraenoic acid

... by the arachidonate 15-Lipoxygenase-1-based or arachidonate 15-lipoxygenased-2-based metabolism of 5-oxo-ETE; and f) conversion ... 12-Lipoxygenase (i.e. ALOX12) to metabolize 5(S)-HETE to 5(S),12(S)-diHETE. The activity of this product has not yet been fully ... also termed arachidonate-5-lipoxygenase, 5-lipoxygenase, 5-LO, and 5-LOX). ALOX5 metabolizes arachidonic acid to its ... Since 5-oxo-ETE is 30- to 100-fold more potent than 5(S)-HETE, 5-HEDH main function may be to increase the biological impact of ...

*Leukotriene C4

doi:10.1016/b978-0-12-394300-2.00002-8. Haeggström, Jesper Z.; Funk, Colin D. (2011-09-22). "Lipoxygenase and Leukotriene ... Arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S), which couples ... "Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis". Proceedings of the ... a Novel Human Microsomal Glutathione S-Transferase with Leukotriene C4 Synthase Activity and Significant Sequence Identity to 5 ...

*List of MeSH codes (D08)

... arachidonate 12-lipoxygenase MeSH D08.811.682.690.416.444.050.065 --- arachidonate 15-lipoxygenase MeSH D08.811.682.690.416.444 ... arachidonate lipoxygenases MeSH D08.811.682.690.416.444.050.055 --- arachidonate 5-lipoxygenase MeSH D08.811.682.690.416.444. ... map kinase kinase 5 MeSH D08.811.913.696.620.682.700.565.600 --- map kinase kinase 6 MeSH D08.811.913.696.620.682.700.565.700 ... map kinase kinase 5 MeSH D08.811.913.696.620.682.725.200.600 --- map kinase kinase 6 MeSH D08.811.913.696.620.682.725.200.700 ...

*Chromosome 10 (human)

Arachidonate 5-Lipoxygenase (processes essential fatty acids to leukotrienes, which are important agents in the inflammatory ... 11 (5): 206. doi:10.1186/gb-2010-11-5-206. PMC 2898077 . PMID 20441615. "Statistics & Downloads for chromosome 10". HUGO Gene ... 5 (1): 69-82. doi:10.1089/109065701750168824. PMID 11336406. National Institutes of Health. "Chromosome 10". Genetics Home ... phosphatidylinositol 5 phosphate 4-kinase type-2 alpha PITRM1: pitrilysin metallopeptidase 1 PLEKHS1 encoding protein ...

*GRB2

Arachidonate 5-lipoxygenase, B-cell linker, BCAR1, BCR gene, Beta-2 adrenergic receptor, C-Met, CBLB, CD117, CD22, CD28, CDKN1B ... 270 (10): 5631-5. doi:10.1074/jbc.270.10.5631. PMID 7534299. Ong SH, Goh KC, Lim YP, Low BC, Klint P, Claesson-Welsh L, Cao X, ... 18 (5): 1147-56. doi:10.1038/sj.onc.1202411. PMID 10022120. Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap ... 19 (5): 3798-807. PMC 84217 . PMID 10207103. Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, ...

*List of EC numbers (EC 1)

... arachidonate 12-lipoxygenase EC 1.13.11.32: 2-nitropropane dioxygenase EC 1.13.11.33: arachidonate 15-lipoxygenase EC 1.13. ... linoleate 8R-lipoxygenase EC 1.13.11.61: linolenate 9R-lipoxygenase EC 1.13.11.62: linoleate 10R-lipoxygenase EC 1.13.11.63: ... arachidonate 8-lipoxygenase EC 1.13.11.41: 2,4'-dihydroxyacetophenone dioxygenase EC 1.13.11.42: deleted EC 1.13.11.43: ... lipoxygenase EC 1.13.11.13: ascorbate 2,3-dioxygenase EC 1.13.11.14: 2,3-dihydroxybenzoate 3,4-dioxygenase EC 1.13.11.15: 3,4- ...

*Anti-inflammatory

Antileukotrines are anti-inflammatory agents which function as leukotriene-related enzyme inhibitors (arachidonate 5- ... lipoxygenase) or leukotriene receptor antagonists (cysteinyl leukotriene receptors) and consequently oppose the function of ... 75 (5): 407-413. doi:10.1139/y97-077. PMID 9250374. Dery, R.E.; Mathison, R.; Davison, J.; Befus; A.D. (2001). "Inhibition of ... 42 (5): 305-14. doi:10.1081/JAS-62950. PMID 16036405. K S Broughton; Johnson, CS; Pace, BK; Liebman, M; Kleppinger, KM (1997-04 ...

*Lipoxygenase

Arachidonate 15-lipoxygenase type II (ALOX15B), also termed 15-lipoxygenase-2, 15-LOX-2, and 15-LOX-2. It metabolizes ... erythrocyte type 15-lipoxygenase (or 15-lipoxygenase, erythrocyte type), reticulocyte type 15-lipoxygenase (or 15-lipoxygenase ... Arachidonate 12-lipoxygenase (ALOX12) (EC 1.13.11.31InterPro: IPR001885), also termed 12-lipoxygenase, platelet type platelet ... There are several lipoxygenase structures known including: soybean lipoxygenase L1 and L3, coral 8-lipoxygenase, human 5- ...

*Arachidonate 8-lipoxygenase

... (EC 1.13.11.40) is an enzyme that catalyzes the chemical reaction arachidonate + O2 ⇌ {\ ... Other names in common use include 8-lipoxygenase, and 8(R)-lipoxygenase. This enzyme participates in arachidonic acid ... Bundy GL, Nidy EG, Epps DE, Mizsak SA, Wnuk RJ (1986). "Discovery of an arachidonic acid C-8 lipoxygenase in the gorgonian ... The systematic name of this enzyme class is arachidonate:oxygen 8-oxidoreductase. ...

*Mead acid

ISBN 9 78-0-19-876802-9. Phinney SD, Odin RS, Johnson SB, Holman RT (1990). "Reduced arachidonate in serum phospholipids and ... In the presence of lipoxygenase, cytochrome p450 or cyclooxygenase Mead acid can form various hydroxyeicosatetraenoic acid ( ... Wei YF, Evans RW, Morrison AR, Sprechert H, Jakschik BA (1985). "Double bond requirement for the 5-lipoxygenase pathway". ... Powell, William S.; Rokach, Joshua (2013). "The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor". Progress in Lipid ...
References for Abcams Recombinant Human 5 Lipoxygenase protein (ab114310). Please let us know if you have used this product in your publication
We mapped a gene predisposing to myocardial infarction to a locus on chromosome 13q12-13. A four-marker single-nucleotide polymorphism (SNP) haplotype in this locus spanning the gene ALOX5AP encoding 5-lipoxygenase activating protein (FLAP) is associated with a two times greater risk of myocardial infarction in Iceland. This haplotype also confers almost two times greater risk of stroke. Another ALOX5AP haplotype is associated with myocardial infarction in individuals from the UK. Stimulated neutrophils from individuals with myocardial infarction produce more leukotriene B4, a key product in the 5-lipoxygenase pathway, than do neutrophils from controls, and this difference is largely attributed to cells from males who carry the at-risk haplotype. We conclude that variants of ALOX5AP are involved in the pathogenesis of both myocardial infarction and stroke by increasing leukotriene production and inflammation in the arterial wall ...
Zileuton is an orally active inhibitor of 5-lipoxygenase, and thus inhibits leukotrienes (LTB4, LTC4, LTD4, and LTE4) formation. Zileuton is used for the maintenance treatment of asthma. Zileuton was introduced in 1996.
Leukotrienes, the biologically active metabolites of arachidonic acid, have been implicated in a variety of inflammatory responses, including asthma, arthritis and psoriasis. Recently a compound, MK-886, has been described that blocks the synthesis of leukotrienes in intact activated leukocytes, but has little or no effect on enzymes involved in leukotriene synthesis, including 5-lipoxygenase, in cell-free systems. A membrane protein with a high affinity for MK-886 and possibly representing the cellular target for MK-886 has been isolated from rat and human leukocytes. Here, we report the isolation of a complementary DNA clone encoding the MK-886-binding protein. We also demonstrate that the expression of both the MK-886-binding protein and 5-lipoxygenase is necessary for leukotriene synthesis in intact cells. Because the MK-886-binding protein seems to play a part in activating this enzyme in cells, it is termed the five-lipoxygenase activating protein (FLAP ...
This report by Pace and colleagues provides new insights into the influence of sex (and sex hormones) on leukotriene synthesis and its inhibition. While the potential of these results to be of clinical relevance is exciting, additional preclinical and clinical studies are needed to define the true clinical impact, which is likely to be complex. For example, Pace et al. focus primarily on inflammatory processes and leukocytes that predominantly generate LTB4. Although a number of inflammatory diseases, including scleroderma lung disease (13), inflammatory bowel disease (6), sickle cell disease (14), and cardiovascular disease (15), are reported to be associated with increased LTB4 levels, there are few, if any, examples in which treatment of these diseases with leukotriene synthesis inhibitors has shown benefit. The diseases in which there is the most information relevant to leukotriene biology are asthma, AERD, and allergic rhinitis, to which cysteinyl leukotrienes are known to contribute. For ...
Recently, we have demonstrated by two different methods that lipoxgenases (LOXs) and 14-3-3 proteins form interactions in barley embryos [Holtman, Roberts, Oppedijk, Testerink, van Zeijl and Wang (2000) FEBS Lett. 474, 48-52]. It was shown by both co-immunoprecipitations and surface-plasmon resonance experiments that 13-LOX, but not 9-LOX, forms interactions with 14-3-3 proteins. In the present report we show that the presence of 13-LOX and 14-3-3 proteins was established in high-molecular-mass complexes. Amounts of 13-LOX and 14-3-3 proteins in high-molecular-mass fractions increased during germination, but were reduced after dephosphorylation of protein extracts or competition with the 14-3-3-binding peptide P-Raf-259, indicating that 13-LOX and 14-3-3 proteins interact in a phosphorylation-dependent manner. Chemicals/CAS: 13-lipoxygenase, EC 1.13.11.-; 14-3-3 Proteins; Lipoxygenase, EC 1.13.11.12; Tyrosine 3-Monooxygenase, EC 1.14.16.2 ...
15 Lipoxygenase 1小鼠单克隆抗体[3G8](ab119774)可与大鼠, 狗, 人, 猴样本反应并经WB, IHC, ICC/IF实验严格验证。所有产品均提供质保服务,中国75%以上现货。
References for Abcams Recombinant Human 15 Lipoxygenase 1 protein (ab114421). Please let us know if you have used this product in your publication
Discovery of selective imidazole-based inhibitors of mammalian 15-lipoxygenase: Highly potent against human enzyme within a cellular environment ...
Zileuton is an orally active inhibitor of 5-lipoxygenase, the enzyme that catalyzes the formation of leukotrienes from arachidonic acid. It is indicated for the prophylaxis and chronic treatment of asthma in adults and children 12 years of age and older.
Complete information for ALOX15 gene (Protein Coding), Arachidonate 15-Lipoxygenase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
abbr.: diHETE; any of several products resulting from dioxygenation of arachidonate at two sites, normally resulting from lipoxygenase action on hydroxyeicosatetraenoates. (6E,8Z,10E,14Z)‐(5S,12S)‐5,12‐dihydroxyeicosa‐6,8,10,14‐tetraen‐1‐oate (abbr.: 5(S),12(S)‐diHETE) is synthesized in human leukocytes by ... ...
BioVision develops and offers a wide variety of products including assay kits, antibodies, recombinant proteins & enzymes, and other innovative research tools for studying Apoptosis, Metabolism, Cell Proliferation, Cellular Stress, Cell Damage and Repair, Diabetes, Obesity and Metabolic Syndrome, Stem Cell Biology, Gene Regulation, Signal Transduction, etc. BioVisions products are currently being sold in more than 60 countries worldwide.
TY - JOUR. T1 - Cigarette smoking stimulates lipoxygenase but not cyclooxygenase pathway in platelets. AU - Chang, Wen Chang. AU - Fukuda, Shoshi. AU - Tai, Hsin Hsiung. PY - 1983/9/15. Y1 - 1983/9/15. N2 - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of carboxyhemoglobin. Arachidonate metabolism through lipoxygenase and cyclooxygenase pathways in platelets was determined. Cigarette smoking increased 12-lipoxygenase activity significantly without affecting the cyclooxygenase pathway. In view of platelet-leukocyte interactions and potent chemotactic activity of 12-HETE for aortic smooth muscle cell migration, increased 12-lipoxygenase activity may predispose individuals to atherosclerosis, thromboembolism and emphysema commonly found in smokers.. AB - Male rats were exposed to freshly generated cigarette smoke once daily for 4 to 8 weeks. Inhalation of smoke was verified by elevated level of ...
Leukotrienes (LT) are a group of proinflammatory lipid mediators that are implicated in the pathogenesis and progression of atherosclerosis. Here we report that mRNA levels for the three key proteins in LTB4 biosynthesis, namely 5-lipoxygenase (5-LO), 5-LO-activating protein (FLAP), and LTA4 hydrolase (LTA4H), are significantly increased in human atherosclerotic plaque (n = 72) as compared with healthy controls (n = 6). Neither LTC4 synthase nor any of the LT receptors exhibits significantly increased mRNA levels. Immunohistochemical staining revealed abundant expression of 5-LO, FLAP, and LTA4H protein, colocalizing in macrophages of intimal lesions. Human lesion tissue converts arachidonic acid into significant amounts of LTB4, and a selective, tight-binding LTA4H inhibitor can block this activity. Furthermore, expression of 5-LO and LTA4H, but not FLAP, is increased in patients with recent or ongoing symptoms of plaque instability, and medication with warfarin correlates with increased levels ...
Title: Imbalance Between Leukotriene Synthesis and Catabolism Contributes to the Pathogenesis of Allergic Diseases. VOLUME: 3 ISSUE: 4. Author(s): Masafumi Zaitsu. Affiliation:Department of Pediatrics,Faculty of Medicine, Saga University, 5-1-1 Nabeshima, Saga City 849-8501, Saga, Japan.. Keywords:Dipeptidases, gamma-glutamyl leukotrienase, stem cell factor, lipopolysaccharide, 5-lipoxygenase. Abstract: Recently, there has been great progress in elucidating the biochemistry of the arachidonic acid (AA) metabolism. The abnormal production of leukotrienes (LTs), due to the unbalanced-regulation of synthesizing and catabolizing enzymes, is probably induced by many bioactive substances, including Th2 cell-derived cytokines. Imbalances in these processes may play an important role in allergic reactions and other inflammatory diseases, thus making them potentially prime therapeutic targets for these diseases. Further studies on the regulation of LT-synthesis and catabolism are therefore required to ...
FLAP antibody, Internal (arachidonate 5-lipoxygenase-activating protein) for IHC-P, WB. Anti-FLAP pAb (GTX89246) is tested in Human samples. 100% Ab-Assurance.
Lipoxygenases play a critical role in the biosynthesis of both proinflammatory and pro-resolving mediators and thus can be critical regulators of their balance. Two key enzymes, 5-LOX and 12/15-LOX, have been studied in this context. Notably, humans express three related forms of this enzyme, 12-LOX, 15-LOX type 1, and 15-LOX type 2, while mice express only one form, which is usually referred to as 12/15-LOX because it catalyzes both 12- and 15-LOX reactions (34). 5-LOX plays a role in the formation of both proinflammatory leukotrienes and pro-resolving lipoxins, and the determination of which product is generated in a given setting is dependent on 5-LOX subcellular localization (34). Nuclear 5-LOX is located near leukotriene A4 (LTA4) hydrolase, which converts the product of 5-LOX, LTA4, to LTB4. In contrast, when 5-LOX is cytoplasmic, LTA4 is converted to lipoxin A4 (LXA4) by cytoplasmic 12/15-LOX. In macrophages, the nuclear localization of 5-LOX is mediated by MAPKAPK2-mediated ...
In the paper entitled "Effect of montelukast added to inhaled budesonide on control of mild to moderate asthma" by M J Vaquerizo et al which appeared in the March issue of Thorax (2003;58:204-11), there is an error in the first sentence of the abstract which should read "Proinflammatory leukotrienes, which are not completely inhibited by inhaled corticosteroids, may contribute to asthmatic problems". The publishers apologise for this error.. ...
Plants continuously have to defend themselves against life threatening events such as drought, mechanical damage, temperature stress and potential pathogens. A main component of the plant defense mechanism is the lipoxygenase pathway. Products of this pathway are involved in wound healing, pest resistance, signaling, or ... read more have antimicrobial and antifungal activity. The first step in the lipoxygenase pathway is the reaction of linoleic or linolenic acids with molecular oxygen, catalyzed by the enzyme lipoxygenase. The formed hydroperoxy fatty acids are highly reactive and dangerous for the plant, and are therefore further metabolized by other enzymes such as allene oxide synthase, hydroperoxide lyase, peroxygenase or divinyl ether synthase. Hydroperoxide lyases are heme-containing enzymes of the cytochrome P450 class (CYP74B). They cleave the C-C bond adjacent to the hydroperoxy group in the lipoxygenase products, resulting in the formation of w-oxo acids and volatile C6- and ...
A1777 is a selective 5-lipoxygenase inhibitor that reduces leukocytes proliferation without affecting the eosinophils of mast cells.
Inflammation in the vascular wall is important for development of atherosclerosis. We have shown previously that arachidonate 15-lipoxygenase type B (ALOX15B) is more highly expressed in human atherosclerotic lesions than in healthy arteries. This en
The incubation of isolated human PMN in vitro results in the rapid accumulation of endogenous adenosine, which has profound inhibitory effects on many cell functions, including LT synthesis. In the present study, we show that when endogenous adenosine is eliminated enzymatically from PMN suspensions, or its actions blocked with receptor antagonists, human PMN respond very strongly to low micromolar concentrations of AA for the synthesis of 5-LO products. This observation contrasts with the widely held perception that resting human PMN respond poorly to exogenous AA for LTB4synthesis and that the measurable synthesis of 5-LO products in the presence of AA requires the simultaneous stimulation with another agonist. Thus, our studies establish clearly that AA can trigger, in the absence of other added PMN stimuli, an important generation of 5-LO products and that the effect of exogenous AA is highly sensitive to the inhibitory effect of adenosine A2a receptor engagement on PMN. Therefore, these ...
We investigated the interaction of human PMNs with human vascular tissue to determine the extent to which cellular activation state was involved in PMN-induced vascular responsiveness. We determined that both unactivated and activated PMNs induced a cell number-dependent vasocontraction in HUV, the nature of which was dependent on the activation state of the cells. The vasoconstrictor response observed for unactivated PMNs was endothelium-independent, was due to soluble factor(s) in the cell supernatant and was partially blocked by an inhibitor of leukotriene biosynthesis. For the activated PMNs, the response was endothelium-dependent, was not due to a soluble factor and was linearly related to their activation state.. One of the most interesting findings of this study was that both unactivated and activated PMNs contracted HUV but that their respective responses were quite different in nature. Treatment of HUV with unactivated PMNs had no significant effect on the response to serotonin, which ...
Dear all, I was hoping someone could help me locate a source for the following antibodies - they are quite urgent and any information on companies selling them would be very welcome. The antibodies are: Phospholipase A2 activating protein Ab. 5-lipoxygenase activating protein 5-lipoxygenase They are required for western blotting. Also any companies (preferably in the UK) which can make them would alos be welcome although those already approached have said it would take 20 weeks to produce these Ab. which is far to long. Thank you all in advance, Gary Morley gmorley at rpms.ac.uk ...
Looking at my sequence of animals, there are a few conclusions I can come to. One conclusion I can come to is that my protein, lipoxygenase, must be very common because a variety of animals are in the sequence you may not think of as relatives. Sense lipoxygenase is involved in the metabolism that shows…
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The invention is directed to the enhanced expression and purification of lipoxygenase enzymes. These enzymes are of wide-spread industrial importance, often produced in heterologous microbial systems. Preferably, the lipoxygenase produced by the methods of the invention is a plant-derived enzyme and expressed at high-levels in a microbial system that includes a protease-deficient host and one or more chaperone expression plasmids. The invention is also directed to amino acid and nucleic acid fragments of the lipoxygenase enzyme including fragments in expression constructs encoding all or a portion of one or more lipoxygenase genes. The invention is also directed to methods of manufacturing bread and other food and also non-food products with lipoxygenase manufactured by the methods of the invention.
N. Topley, R. Steadman, B. Spur, J.D. Williams; Independent Activation of the 5-Lipoxygenase Pathway and Respiratory Burst in Human Polymorphonuclear Leukocytes (PMN) in Response to Phagocytic Stimuli. Clin Sci (Lond) 1 January 1988; 74 (s18): 65P-66P. doi: https://doi.org/10.1042/cs074065Pc. Download citation file:. ...
Lipid bodies are cellular compartments containing triacylglycerols. They are encompassed by a phospholipid monolayer and decorated with characteristic proteins. In plants, lipid bodies are synthesized during seed formation but acquire new proteins during seed germination. In germinating cucumber (Cucumis sativus) seeds, the set of newly synthesized proteins appearing in the lipid bodies at the early stage of triacylglycerol mobilization comprises a special form of lipoxygenase. We isolated the lipid body lipoxygenase and characterized fragments prepared by limited proteolysis and cleavage with cyanogen bromide. A very early expression of lipid body lipoxygenase was found by studying the rate of de novo synthesis of lipoxygenase forms during germination. This allowed a clear distinction of this enzyme from other lipoxygenase isoforms. Hence, for determining the molecular structure of lipid body lipoxygenase we analyzed a cDNA prepared from mRNA of cotyledons at day 1 of germination. From the cDNA ...
Bermudez, AF, Coles, B, Coffey, M and ODonnell, V (2003) Protein kinase C regulates 15-lipoxygenase oxidation of membrane-bound arachidonate in human monocytes In: 10th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicne, 2003-11-20 - 2003-11-24, SEATTLE, WASHINGTON. Full text not available from this repository ...
Cancer cell metastasis is the single most threatening occurrence of tumor progression and predicts patient prognosis as well as survival. Invasion can be regulated by the Met receptor tyrosine kinase (c-Met), integrin beta4, and the lipid enzyme, 12-Lipoxygenase (12-LOX). Therefore we sought to determine if beta4, c-MET and 12-LOX comprise a signaling axis. c-Met is implicated in cancer cell dissemination through regulation of invasion in EMT where cell-cell junctions are disturbed to allow motility. Furthermore, beta4 promotes cellular adhesion to the extracellular matrix through hemidesmosomes. However, the homeostatic signaling functions of beta4s cytoplasmic tail can be hijacked by growth factor receptors during tumor growth to promote tumor cell survival and metastasis. Beta4 interacts with 12-LOX, an enzyme that metabolizes arachidonic acid to yield 12(S)-HETE, a bioactive lipid that also promotes invasion, tumor growth, and resistance to apoptosis. Our findings reveal that c-Met and beta4
Madeswaran, Arumugam, Muthuswamy Umamaheswari, Kuppuswamy Asokkumar, Thirumalaisamy Sivashanmugam, Varadharajan Subhadradevi, Puliyath Jagannath (2011) Docking studies: In silico lipoxygenase inhibitory activity of some commercially available flavonoids. [Publication] Full text not available from this repository ...
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Lipoxygenases (EC 1.13.11.-) are a family of (non-heme), iron-containing enzymes most of which catalyze the dioxygenation of polyunsaturated fatty acids in lipids containing a cis,cis-1,4- pentadiene into cell signaling agents that serve diverse roles as autocrine signals that regulate the function of their parent cells, paracrine signals that regulate the function of nearby cells, and endocrine signals that regulate the function of distant cells. The lipoxygenases are related to each other based upon their similar genetic structure and dioxygenation activity. However, one lipoxygenase, ALOXE3, while having a lipoxygenase genetic structure, possesses relatively little dioxygenation activity; rather its primary activity appears to be as an isomerase that catalyzes the conversion of hydroperoxy unsaturated fatty acids to their 1,5-epoxide, hydroxyl derivatives. Lipoxygenases are found in eukaryotes (plants, fungi, animals, protists); while the third domain of terrestrial life, the archaea, ...
It is clear that leukotrienes mediate inflammatory response; new aspects of leukotriene function have recently been described. In this study, we demonstrate that leukotrienes are key chemical mediators in the control of parasite burdens in mice infected with Strongyloides venezuelensis. High leukotriene levels were detected in the lungs and small intestines of Swiss mice. In infected Swiss mice treated with MK886, a leukotriene synthesis inhibitor, numbers of adult worms, and eggs/g/feces were greater than in infected-only animals. The MK886 treatment inhibited leukotriene B-4 production in the lungs and small intestines, albeit on different postinfection days. Similarly, parasite burdens and eggs/g/feces were greater in 5-lipoxygenase(-/-) mice than in wild-type animals. These observation were confirmed by histopathological study of the duodena. We subsequently observed significant lower numbers of eosinophils; and mononuclear cells in the blood, peritoneal cavity fluid, and bronchoalveolar ...
Cholesterol metabolism in normal adrenal cortex cells is acutely regulated by ACTH stimulation, rising appreciably within 3 minutes of treatment and peaking within 10-15 minutes (3). Defects in either PKA or G protein coupling, as seen in mutant mouse adrenal cell sub-lines, block this response by preventing cAMP formation (11). Other signaling pathways playing key roles in adrenal responses to ACTH include lipoxygenase activation (12) and, at least in adrenal fasciculata cells, stimulation mediated by receptors for IGF1, retinoids, and thyroid hormone; several cytokines, conversely, can suppress production of steroid hormones by these cells (13). For the most part, I will focus here on the mechanisms of acute adrenal fasciculata responses to cAMP and its analogs, which are generally shared with testicular and ovarian cells. It is interesting to note, however, that StAR regulation in another adrenal steroidogenic cell type, the glomerulosa cell, responds via alternative pathways involving Ca2+ ...
This work describes the structure of human 5-lipoxygenase (5-LOX) (Gilbert, Bartlett et al. 2011) and the techniques required to ascertain the structure. 5-LOX is a notoriously unstable enzyme with important biological functions. The human 5-LOX has been implicated in many disease states including asthma, atherosclerosis and cancer. Part of 5-LOX biology is the inherent instability of the enzyme, which is thought to help regulate the production of its pro-inflammatory products, the leukotrienes. Our objective was stabilizing the enzyme for in vitro studies without affecting catalytic fidelity. I was able to quantitate stabilizing and destabilizing point mutations of 5-LOX by thermal denaturation and kinetic analysis along with other biochemical techniques. Through rigorous site-directed mutagenesis experiments and multiple expression protocols, I was able to over-express an engineered form of 5-LOX that is soluble and stable for biochemical studies and most importantly amenable to crystallization. Our
Reactive oxygen species (ROS) and the redox state of a cell have been implicated in several signal transduction cascades including those that regulate cell proliferation. Specifically, signaling by several growth factors, including epidermal growth factor (EGF), produces a transient increase in ROS. One effect of increases in ROS is the inactivation of tyrosine phosphatases. Pani et al. found that the redox status of cells in culture was different in sparse and dense cultures (sparse cultures have more ROS than dense cultures) and that this difference correlated with whether the cells exhibited contact inhibition. Dense cultures had lower levels of the active [guanosine triphosphate (GTP)-bound] form of the small GTPase Rac-1. Treatment of sparse cultures with drugs to inhibit leukotriene biosynthesis decreased the levels of ROS to those measured in dense cultures, suggesting that Rac-1 may stimulate leukotriene biosynthesis as a mechanism to increase ROS in sparsely cultured cells. The authors ...
Leukotrienes (LT) C4, D4, and E4are major contributors to the pathobiology of human bronchial asthma. Therefore, it is likely that compounds that antagonize the action or inhibit the formation of...
p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.,/p> ,p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.,/p> ,p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).,/p> ,p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x,sup>64,/sup> + x,sup>4,/sup> + x,sup>3,/sup> + x + 1. The algorithm is described in the ISO 3309 standard. ,/p> ,p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.,br /> ,strong>Cyclic redundancy and other checksums,/strong>,br /> ,a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993),/a>),/p> Checksum:i ...
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Sigma-Aldrich offers abstracts and full-text articles by [Maaike Bruinsma, Sarah van Broekhoven, Erik H Poelman, Maarten A Posthumus, Martin J Müller, Joop J A van Loon, Marcel Dicke].
Gingerforce modulates the 5-lipoxygenase enzyme. Garlicforce by New Chapter Supports stomach, liver, and intestinal health. Garlicforce Supports blood platelet health and cardiovascular function and Promotes healthy inflammation response.
ethyl arachidonate 1808-26-0 NMR spectrum, ethyl arachidonate H-NMR spectral analysis, ethyl arachidonate C-NMR spectral analysis ect.
Eoxins are proposed to be a family of proinflammatory eicosanoids (signaling compounds that regulate inflammatory and immune responses). They are produced by human eosinophils (a class of white blood cells), mast cells, the L1236 Reed-Sternberg cell line derived from Hodgkins Lymphoma, and certain other tissues tissue. These cells produce the eoxins by initially metabolizing arachidonic acid, an omega-6 (ω-6) fatty acid, via any enzyme possessing 15-lipoxygenase activity. The product of this initial metabolic step, 15(S)-hydroperoxyeicosatetraenoic acid, is then converted to a series of eoxins by the same enzymes that metabolize the 5-lipoxygenase product of arachidonic acid metabolism, i.e. 5-hydroperoxy-eicosatetraenoic acid to a series of leukotrienes. That is, the eoxins are 14,15-disubstituted analogs of the 5,6-disubstituted leukotrienes. A closely related set of 15-lipoxygenase metabolites are derived from anandamide (i.e. arachidonic acid containing ethanolamine esterified to its ...
5-oxo-6-trans-leukotriene B4 is the metabolite of lipid omega-oxidation of leukotriene B4 (LTB4). LTB4 is the major metabolite in neutrophil polymorphonuclear leukocytes. Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes. Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either LTB4 (leukotriene B4) by LTA4 hydrolase or LTC4 (leukotriene C4) by LTC4 synthase. The regulation of leukotriene production occurs at various levels, including expression of 5-LO, translocation of 5-LO to the perinuclear region and phosphorylation to either enhance or inhibit the activity of 5-LO. Biologically active LTB4 is metabolized by w-oxidation carried out by specific cytochrome P450s (CYP4F) followed by beta-oxidation from the w-carboxy position and after CoA ester formation. (PMID: 7649996 , 17623009 , 2853166 , ...
Leukotrienes are chemicals that are naturally made by your body. Leukotrienes are increased in the bodies of adults and children with asthma and allergies and cause some of the symptoms of these diseases. Leukotrienes are increased in the bodies of adults who have common colds and are believed to cause some of the symptoms of the common cold. It is not known if increases in leukotrienes are related to the symptoms of the common cold in children. There are also genes that may control levels of leukotrienes and other chemicals in your body during the common cold. If you enroll your child in this study, he/she will be tested for allergies and for genes that may control the levels of leukotrienes and other chemicals.. STUDY DESIGN:. There will be 40 subjects enrolled into the study between the ages of 6 to , 14 years of age. However, approximately 80 participants may have to sign the consent form and undergo screening activities in order enroll these 40 subjects. The study will last approximately 1 ...
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins ...
Cysteinyl leukotrienes production in interactions between activated platelet and PMN leukocytes... Leukocytes contain phospholipase A3and 5-lipoxygenase. Thus they can generate LTA4.In contrast, other blood cell, such as erythrocytes and platelets or vascular endothelial cells contain LTA4hydrolase or LTC4synthase, but they lack 5-lipoxygenase and cannot generate their own LTA4. Activated platelet may receive LTA4 from PMN leukocyte ,using transcellular biosynthesis, and produce LTC4.4 LTC4and its metabolites LTD4,LTE4, are potent mediators of vasoconstriction and increase vascular permeability.. ...
A compound of the formula ##STR1## wherein n is an integer from 2 to 4; m is an integer from 3 to 5; R is OM, OR1 or NR2 R3 where M is a pharmaceutically acceptable cation; R1, R2 and R3 are the same or different and selected from the group consisting of hydrogen, C1 -C12 branched, unbranched or cyclic alkyl, aryl and aralkyl; or R2 and R3 taken together form a group of the formula ##STR2## can be used as an inhibitor of the lipoxygenase pathway of the arachidonic acid cascade in animals.
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This study was performed to determine whether using high power microscopic analysis and two putative biochemical fertility markers, 15-lipoxygenase (15-LOX) and ubiquitin (UBI), could be used to accurately evaluate boar ...
BACKGROUND: Nasal polyposis is a chronic inflammatory disease of the upper respiratory tract that affects around 2% of the population and almost 67% of patients with aspirin-intolerant asthma. Polyps are rich in mast cells and eosinophils, resulting in high levels of the proinflammatory cysteinyl leukotrienes. OBJECTIVES: To better understand the role of the proinflammatory leukotrienes in nasal polyposis, we asked the following questions: (1) How do nasal polyps produce leukotriene C(4) (LTC(4))? (2) Can LTC(4) feed back in a paracrine way to maintain mast cell activation? (3) Could a combination therapy targeting the elements of this feed-forward loop provide a novel therapy for allergic disease? METHODS: We have used immunohistochemistry, enzyme immunoassay, and cytoplasmic calcium ion (Ca(2+)) imaging to address these questions on cultured and acutely isolated human mast cells from patients with polyposis. RESULTS: Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels
Bacterial endotoxin produces sepsis associated with alterations in body temperature (fever or hypothermia). The intraperitoneal administration of bacterial endotoxin, lipopolysaccharide (LPS; 50 μg/mouse) led to a decrease in colonic temperature starting 1 hr after the injection. The hypothermic effect was accompanied by a significant increase in hypothalamic leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) levels. 5-lipoxygenase inhibitor, zileuton (200 and 400 Mg/kg. po) administered 30 min before LPS challenge significantly prevented hypothermia. However, non-selective cyclooxygenase inhibitor, indomethacin (10, 20 mg/kg, po) did not reverse the hypothermic response. Further, pretreatment of mice with zileuton prevented LPS-stimulated increase in hypothalamic LTB4 levels and caused a relatively small increase in PGEz levels. Indomethacin had no effect on LTB4 levels but it reduced PGE2 levels. These results suggest a possible involvement of leukotrienes in LPS-induced hypothermia and the ...
Variable responsiveness to zileuton, a leukotriene antagonist used to treat asthma, may be due in part to genetic variation. While individual SNPs were previously associated with zileuton-related lung function changes, specific quantitative trait loci (QTLs) and biological pathways that may contribute have not been identified. In this study, we investigated the hypothesis that genetic variation within biological pathways is associated with zileuton response. We performed an integrative QTL mapping and pathway enrichment study to investigate data from a GWAS of zileuton response, in addition to mRNA expression profiles and leukotriene production data from lymphoblastoid cell lines (LCLs) (derived from asthmatics) that were treated with zileuton or ethanol (control ...
Enzymes of wheat flour have an important role in production of various cereal products, especially bread, and therefore accurate measurement of enzymatic activity along with improvement of this characteristic is the basis of most studies in baking industry. In the present work, physical properties of three wheat varieties (Mahdavi, Kavir ...
Lovat, P.E., Oliverio, S., Ranalli, M., Corazzari, M., Rodolfo, C., Bernassola, F., Aughton, K., Maccarrone, M., Campbell-Hewson, Q., Pearson, A.D.J., Melino, G., Piacentini, M., Redfern, C.P.F ...
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ALOX15 Full-Length MS Protein Standard (NP_001131), Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine, was produced in human 293 cells (HEK293) with fully chemically defined cell culture medium to obtain incorporation efficiency at Creative-Proteomics.
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c-kit ligand (KL) activated mouse bone marrow-derived mast cells (BMMC) for the dose- and time-dependent release of arachidonic acid from cell membrane phospholipids, with generation of leukotriene (LT) C4 in preference to prostaglandin (PG)D2. KL at concentrations of 10 ng/ml elicited half-maximal eicosanoid generation and at concentrations of , 50 ng/ml elicited a maximal generation of approximately 15 ng LTC4 and 1 ng PGD2 per 10(6) cells, with 20% net beta-hexosaminidase release 10 min after stimulation. Of the other cytokines tested, none, either alone or in combination with KL, elicited or modulated the immediate phase of mediator release by BMMC, indicating strict specificity for KL. Activation of BMMC in response to KL was accompanied by transient phosphorylation of cytosolic phospholipase A2 and reversible translocation of 5-lipoxygenase to a cell membrane fraction 2-5 min after stimulation, when the rate of arachidonic acid release and LTC4 production were maximal. BMMC continuously ...
There has been a considerable increase in our understanding of the role of arachidonic acid metabolites in asthma over the last decade. Arachidonic acid provides a source for both leukotrienes and prostanoids which have a diverse range of properties that are important in regulating the airway inflammatory response. It is clear that cysteinyl leukotrienes are important pro-inflammatory mediators in asthma which act to enhance bronchoconstriction. This has led to the development of a number of agents which either target the enzymes involved in leukotriene synthesis or are antagonists at specific leukotriene receptors. The development of these agents has allowed the role of leukotrienes in different variants of asthma to be studied. The other arm of arachidonic acid metabolism is the cyclo-oxygenase pathway. Cyclo-oxygenase exists in two forms-a constitutive form, COX-1, responsible for the production of housekeeping prostaglandins, and an inducible form, COX-2, which is involved in inflammatory ...
The trial achieved its primary efficacy endpoint of demonstrating a reduction in one or more of these key biomarkers. The results showed that at all dose levels DG031 suppressed production of leukotriene B4 (LTB4), the product of the branch of the leukotriene pathway that deCODEs genetics research has linked to increased risk of heart attack. At the highest dose level, DG031 reduced levels of myeloperoxidase (MPO), higher levels of which have been linked to increased risk of heart attack. These effects were dose-dependent. The study also demonstrated that at the highest dose, DG031 lowered levels of sICAM-I, a critical molecule in the activation of inflammatory cells and cell infiltration. There were no serious drug-related adverse events reported in this study, and DG031 was found to be well tolerated.. "Our population genetics work pointed us to the role of the leukotriene pathway and LTB4 in driving the inflammatory process underlying heart attack. DG031 is designed to inhibit the FLAP, or ...
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... | Herbal Products | Silverton, Pretoria | Our Boswellia Capsules Alleviates Ulcerative Colitis And Crohnrsquo;s Disease. Reduces Inflammation By Suppressing The 5-Lipoxygenase Enzyme That Catalyzes The Endogenous Production Of The Inflammatory Elcosanoids, Lipoxins And Serie 4 Leukotrienes. Including Leukotriene B4. Stimulates The Differentiation Of Leukaemia Cells Back To Normal And Also Stimulates The Apoptosis Of Leukaemia Cells. Alleviate The Inflammation Associated With Fibrositis, Osteoarthritis Rheumatoid Arthritis And Reduce Stiffness And Tenderness Of Joints. Reduces And Improve Breathing Capacity In Asthma Patients. Alleviate The Inflammation Associated With Psoriasis. Ingredients: Boswellia.
Actual Singulair side effects submitted by users. Singulair is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body rele...
Actual Singulair side effects submitted by users. Singulair is a leukotriene (loo-koe-TRY-een) inhibitor. Leukotrienes are chemicals your body rele...
This invention is in the field of antiinflammatory pharmaceutical agents and specifically relates to compounds, compositions and methods for treating disorders mediated by cyclooxygenase-2 or 5-lipoxygenase, such as inflammation. Compounds of particular interest are defined by Formula I wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification.
Deschamps, J. D., Gautschi, J. T., Whitman, S., Johnson, T. A., Gassner, N. C., Crews, P., & Holman, T. R. (2007). Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg ...
The only disclosure restriction on the PI is that the sponsor can review results communications prior to public release and can embargo communications regarding trial results for a period that is more than 60 days but less than or equal to 180 days. The sponsor cannot require changes to the communication and cannot extend the embargo ...
LTC4, LTD4, and LTE4 are leukotrienes (cys-LTs) derived from arachidonic acid as a result of immune or inflammatory stimuli. The above mentioned…
In Vivo Experiments. All animal experiments described in this study were performed after review of the protocols and approval by the Institutional Animal Care and Use Committee.. Murine Whole-Blood Leukotriene B4, Cysteinyl Leukotriene, Lipoxin A4, and PGE2 Assays. For in vitro assays of ionophore-stimulated lipid mediator production, CD-1 mice were euthanized, and blood was collected in heparin-containing syringes by cardiac puncture. The blood was diluted 1:2 (LTB4, LXA4) or 1:15 (LTC4/D4/E4, PGE2) in RPMI 1640 medium, and 200-μl aliquots of the diluted blood were added to wells of a 96-well tissue culture plate. JNJ-26993135 or the 5-lipoxygenase inhibitor zileuton were added at different concentrations to the diluted whole blood (final DMSO concentration of 0.1%) and preincubated for 15 min at 37°C in a humidified incubator. For murine ex vivo analysis of LTB4 production, blood was obtained from BALB/c mice 4 h after oral dosing of JNJ-26993135 and was diluted 1:1 in RPMI 1640 medium, ...
Cancer Metastasis Rev. 2007 Dec;26(3-4):503-24. Research Support, N.I.H., Extramural; Research Support, Non-U.S. Govt; Research Support, U.S. Govt, Non-P.H.S.; Review
Purified human monocytes release and metabolize endogenous arachidonic acid (20:4) from phospholipid stores when challenged with particulate inflammatory stimuli or the calcium ionophore A23187. Using radiolabeled cultures, the percentage of total [3H]20:4 released was similar with each type of stimulus. However, the spectrum of 20:4 metabolites differed. With opsonized zymosan (OpZ) or Sephadex beads coated with IgG immune complexes (Ig-beads), the predominant product was thromboxane (25% of the total) together with smaller amounts of other cyclo-oxygenase products and lipoxygenase metabolites. Levels of thromboxane synthesis by monocytes were comparable to those by platelets, as measured by radioimmunoassay. In contrast, exposure to the nonspecific agent A23187 led to mainly lipoxygenase products (70% of the total). Monocytes isolated from mononuclear cell fractions of peripheral blood contain platelets specifically rosetted to their surfaces. These platelet contaminants were removed by ...
Our previous studies suggested that enhanced pulmonary artery contractions to arachidonic acid in females compared with males were mediated by an LO metabolite.6 The purpose of the current study was to systematically characterize the LO pathways in female and male pulmonary arteries. First, it was shown that the protein expression of both 15- and 5-LO was greater in females compared with males. Although pulmonary arteries from both male and females produced the corresponding LO metabolites, 15- and 5-HETE, only the synthesis of 15-HETE was enhanced in females. The increase in 15-HETE was correlated with an increased 15-HETE-mediated pulmonary artery vasoconstriction in females compared with males. These findings are significant because it is the first report that the 15-LO pathway is regulated in a sex-specific way. These results may impact what is known about the sex differences in the incidence of PAH.. The enhanced vasoconstriction in females compared with males could be because of increased ...
It is not within the scope of this Review to give a comprehensive description of all pathologies potentially involving leukotrienes. Here, I would like to mention four disease areas that are currently attracting considerable attention. Firstly, leukotrienes are strongly implicated in immunometabolic disorders ranging from obesity to type 2 diabetes. It has been demonstrated that enzymes and receptors of the 5-LOX pathway are upregulated in adipose tissue and that mouse and human adipocytes can secrete leukotrienes (97, 98). Importantly, LTB4 appears to play a critical role in adipose tissue inflammation, and a FLAP antagonist reduced 5-LOX products and macrophage accumulation in adipose tissue in mice with dietary obesity (97). In addition, pharmacological or genetic ablation of the 5-LOX pathway in WT mice on a high-fat diet resulted in a reduction of adipose tissue macrophage and insulin resistance (98). Recent data demonstrate a similar role for LTB4 in promoting liver steatosis and insulin ...
Barley plants having reduced lipoxygenase-1 enzyme activity are provided, for example, barley plants expressing mutant LOX-1 protein. The barley plants of the invention are useful in the production of plant products such as malt and brewed beverages, particularly beer, having increased stability and reduced T2N potential.
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Deregulation of the oxidative cascade of poly-unsaturated fatty acids (PUFAs) has been associated with several cancers, including chronic lymphocytic leukemia (B-CLL). Leukotriene B4 (LTB4), a metabolite of arachidonic acid (AA), is produced by B-CLL and contributes to their survival. The aim of the present study was to analyze the activity of the oxidative cascade of PUFAs in B-CLL. Purified B cells from patients and normal B CD5 positive cells were subjected to flow cytometry, Western-blot and RT-qPCR analyses. LTB4 plasma and intracellular concentrations were determined by ELISA. Our results showed that aggressive B-CLL tumor cells, i.e. cells with an annual proliferation index above 2, over-expressed calcium-dependent and calcium-independent phospholipases A2 (cPLA2-alpha and iPLA2-beta, respectively), 5-lipoxygenase (5LOX) and leukotriene A4 hydroxylase (LTA4H). Intracellular LTB4 levels were lower in the most aggressive cells than in cells with a smaller proliferation index, despite equivalent
b. Functional inhibition of cells involved in physiopathological processes, such as platelet, responsible for thrombogenic events through the formation of thromboxane A2 via the cyclo-oxygenase pathway, and leukocytes, involved in inflammatory processes, through the formation of leukotrienes via the lipoxygenase pathway. In addition phenols modulate enzymes that regulate functions: the synthesis of nitric oxide (NO), a potent vasodilatator, by macrophages, is increased, while the production of the free radical anion superoxide, by the same type of cell, is reduced. In contrast, these activities are not shown by typical lipophilic antioxidants (e.g. Vitamin E). Phenols in olive oil share, therefore, a broad spectrum of biological activities, in addition to acting simply as antioxidants. This may be attributed to the chemical characteristics of these compounds, amphiphilic molecules, i.e. partly lipophilic with the typical lipid antioxidant activity (like Vitamin E) and partly hydrophilic, with ...
Untersuchungen an 1,4-Naphthochinonen, 25. Mitt. Reaktion des Redox 5-Lipoxygenase-Inhibitors 2-(3,5-Di-tert-butyl-4-hydroxyphenyl)-3-hydroxy-1,4-naphthochinon mit O2•-- und 3O2 (1,4-Naphthoquinones. 25. Reaction of the redox 5-lipoxygenase inhibitor 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-hydroxy-1,4-naphthoquinone with O2•- and 3O2) ...
Untersuchungen an 1,4-Naphthochinonen, 25. Mitt. Reaktion des Redox 5-Lipoxygenase-Inhibitors 2-(3,5-Di-tert-butyl-4-hydroxyphenyl)-3-hydroxy-1,4-naphthochinon mit O2•-- und 3O2 (1,4-Naphthoquinones. 25. Reaction of the redox 5-lipoxygenase inhibitor 2-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-hydroxy-1,4-naphthoquinone with O2•- and 3O2) ...
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The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
Bermudez, AF, Coles, B, Coffey, M and ODonnell, V (2003) Protein kinase C regulates 15-lipoxygenase oxidation of membrane-bound arachidonate in human monocytes In: 10th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicne, 2003-11-20 - 2003-11-24, SEATTLE, WASHINGTON. ...
Bryant, R.W., Bailey, J.M., Schewqe, T. and Rapoport, S.M. (1982). „Positional specificity of a reticulocyte lipoxygenase. Conversion of arachidonic acid to 15-S-hydroperoxy-eicosatetraenoic acid". J. Biol. Chem. 257: 6050-6055. PMID 6804460 ...
Background: The 5-lipoxygenase inhibitor VIA-2291 effectively lowers production of leukotriene metabolites. This study investigates the relations between inflammation, coronary plaque characteristics and left ventricular function in response to treatment with VIA-2291 (Atreleuton) in patients after an acute coronary syndrome (ACS).. Methods: Fifty six post-ACS patients who participated in a randomized trial evaluating the effects of VIA-2291 vs. placebo and underwent cardiac computed tomography angiography were studied. Leukotriene E4 (LTE4), high-sensitivity C-reactive protein (hs-CRP), coronary plaque volume (PV) with vulnerable characteristics (Necrotic Core) and left ventricular ejection fraction (LVEF) were measured at baseline and at 6-month follow-up. The relation of changes in LTE4, hs-CRP, PV and LVEF in response to VIA-2291 was analyzed using conditional logistic regression analyses.. Results: From baseline to 6 months, after adjustment for risk factors, significant reductions in LTE4, ...
Osteoporosis is one of the worlds major medical burdens in the twenty-first century. Pharmaceutical intervention currently focusses on decelerating bone loss, but phytochemicals such as baicalein, which is a lipoxygenase inhibitor, may rescue bone loss. Studies evaluating the effect of baicalein in vivo are rare. We administered baicalein to sixty-one three-month-old female Sprague-Dawley rats. They were divided into five groups, four of which were ovariectomized (OVX) and one non-ovariectomized (NON-OVX). Eight weeks after ovariectomy, bilateral tibial osteotomy with plate osteosynthesis was performed and bone formation quantified. Baicalein was administered subcutaneously using three doses (C1: 1 mg/kg BW; C2: 10 mg/kg BW; and C3: 100 mg/kg BW) eight weeks after ovariectomy for four weeks. Finally, femora and tibiae were collected. Biomechanical tests, micro-CT, ashing, histological and gene expression analyses were performed. Biomechanical properties were unchanged in tibiae and reduced in femora.
The 5-lipoxygenase (5-LO) product 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE), which is a potent chemoattractant for myeloid cells, is known to promote the survival of prostate cancer cells. In the present study, we found that PC3 prostate cancer cells and cell lines derived from breast (MCF7) and lung (A-427) cancers contain 5-hydroxyeicosanoid dehydrogenase (5-HEDH) activity and have the ability to synthesize 5-oxo-ETE from its precursor 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) when added as an exogenous substrate. H2O2 strongly stimulated the synthesis of 5-oxo-ETE and induced dramatic increases in the levels of both glutathione disulfide and NADP+. The effects of H2O2 on 5-oxo-ETE and NADP+ were blocked by N-ethylmaleimide (NEM), indicating that this effect was mediated by the glutathione reductase-dependent generation of NADP+, the cofactor required by 5-HEDH. 5-Oxo-ETE synthesis was also stimulated by agents that have cytotoxic effects on tumor cells, including ...
B83 The purpose of this research project was to determine the efficacy of the cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors, alone or in combination, to prevent OH-BBN-induced urinary bladder cancers in female Fischer-344 rats. In this OH-BBN-induced rat model, the bladder cancers are primarily transitional cell carcinomas which are mostly papillary and slowly growing. The rats were treated for 8 weeks with OH-BBN beginning at 49 days of age, then treated with chemopreventive agents and followed for an additional 6-7 months for the appearance of urinary bladder cancers. Beginning one week following the last OH-BBN administration and continuing until the end of the study, celecoxib (a COX2 inhibitor) was administered at 500 mg/kg diet, zileuton (a LOX inhibitor) at 1200 mg/kg diet, naproxen (a nonspecific COX inhibitor) at 200 or 400 mg/kg diet, aspirin (a COX1 inhibitor) at 300 and 3000 mg/kg diet, and caffeic acid (a LOX inhibitor) at 8 and 16 grams/kg diet. At the end of the study ...
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View Notes - Eicosanoid Synthesis from BCH 4024 at University of Florida. Molecular Biochemistry II Eicosanoid Synthesis Copyright 1999-2008 by Joyce J. Diwan. All rights reserved. Prostaglandins and

Arachidonate 5-lipoxygenase - WikipediaArachidonate 5-lipoxygenase - Wikipedia

Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... "Alox5 - arachidonate 5-lipoxygenase". WikiGenes.. *^ Fahel JS, de Souza MB, Gomes MT, Corsetti PP, Carvalho NB, Marinho FA, de ... arachidonate 5-lipoxygenase activity. • dioxygenase activity. • metal ion binding. • protein binding. • oxidoreductase activity ... lipoxygenase pathway. • neutrophil degranulation. • cytokine-mediated signaling pathway. • interleukin-18-mediated signaling ...
more infohttps://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase

Arachidonate 5-lipoxygenase - WikipediaArachidonate 5-lipoxygenase - Wikipedia

Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13 ... "Alox5 - arachidonate 5-lipoxygenase". WikiGenes.. *^ Fahel JS, de Souza MB, Gomes MT, Corsetti PP, Carvalho NB, Marinho FA, de ... arachidonate 5-lipoxygenase activity. • dioxygenase activity. • metal ion binding. • protein binding. • oxidoreductase activity ... lipoxygenase pathway. • neutrophil degranulation. • cytokine-mediated signaling pathway. • interleukin-18-mediated signaling ...
more infohttps://en.m.wikipedia.org/wiki/5-Lipoxygenase

RCSB PDB - Protein Feature View 









 - Arachidonate 5-lipoxygenase - P09917 (LOX5 HUMAN)RCSB PDB - Protein Feature View - Arachidonate 5-lipoxygenase - P09917 (LOX5 HUMAN)

The PDB archive contains information about experimentally-determined structures of proteins, nucleic acids, and complex assemblies. As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
more infohttp://www.rcsb.org/pdb/protein/E5FPY8

Arachidonate 5-lipoxygenase inhibitor - WikipediaArachidonate 5-lipoxygenase inhibitor - Wikipedia

Lipoxygenase inhibitors at the US National Library of Medicine Medical Subject Headings (MeSH) MeSH list of agents 82016859. ... Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5- ... lipoxygenase or 5-LOX) enzyme, which is responsible for the production of inflammatory leukotrienes. The overproduction of ... Arachidonate 5-lipoxygenase ...Specific function: Catalyzes the first step in leukotriene biosynthesis, and thereby plays a ...
more infohttps://en.wikipedia.org/wiki/Arachidonate_5-lipoxygenase_inhibitor

OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase...OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase...

OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase ... OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase ... OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase ... OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/23643940

Arachidonate 5-lipoxygenase elisa and antibodyArachidonate 5-lipoxygenase elisa and antibody

Recombinant Protein and Arachidonate 5-lipoxygenase Antibody at MyBioSource. Custom ELISA Kit, Recombinant Protein and Antibody ... Arachidonate 5-lipoxygenase. Arachidonate 5-lipoxygenase ELISA Kit. Arachidonate 5-lipoxygenase Recombinant. Arachidonate 5- ... lipoxygenase Antibody. Also known as Arachidonate 5-lipoxygenase (5-LO) (5-lipoxygenase).. Catalyzes the first step in ... Below are the list of possible Arachidonate 5-lipoxygenase products. If you cannot find the target and/or product is not ...
more infohttps://www.mybiosource.com/protein_family.php?root=arachidonate-5-lipoxygenase

Arachidonate 5-lipoxygenase-activating proteinArachidonate 5-lipoxygenase-activating protein

THE 5-LOX interface involving the four cysteines 159, 300, 416 and 418 is important for the translocation to the nuclear ... Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein.. 26159646. 2015. Variants in the ... Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5- ... lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this ...
more infohttps://pharos.nih.gov/idg/targets/P20292

Rabbit 5-LO (Arachidonate 5-Lipoxygenase) ELISA Kit Manufacturers in DelhiRabbit 5-LO (Arachidonate 5-Lipoxygenase) ELISA Kit Manufacturers in Delhi

Arachidonate 5-Lipoxygenase) ELISA Kit OSCAR DIAGNOSTIC SERVICES PVT. LTD.is an India based Company in Delhi. ... Arachidonate 5-Lipoxygenase) ELISA Kit. Rabbit 5-LO (Arachidonate 5-Lipoxygenase) ELISA Kit. ... Arachidonate 5-Lipoxygenase) ELISA Kit » Rabbit 5-LO (Arachidonate 5-Lipoxygenase) ELISA Kit. Rabbit 5-LO (Arachidonate 5- ... Lipoxygenase) ELISA Kit. Rabbit 5-LO (Arachidonate 5-Lipoxygenase) ELISA Kit. Rabbit 5-LO (Arachidonate 5-Lipoxygenase) ELISA ...
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Arachidonate-5-Lipoxygenase (ALOX5): A Master Regulator for Prostate Cancer Cell SurvivalArachidonate-5-Lipoxygenase (ALOX5): A Master Regulator for Prostate Cancer Cell Survival

... Jagadananda Ghosh*. Departments of ... Central role of arachidonate 5-lipoxygenase in the regulation of cell growth and apoptosis in human prostate cancer cells. Adv ... Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells. Proc. Natl. Acad. Sci. USA ... Cite this article as: Ghosh J. Arachidonate-5-Lipoxygenase (ALOX5): A Master Regulator for Prostate Cancer Cell Survival. Clin ...
more infohttp://www.clinicsinoncology.com/full-text/cio-v2-id1277.php

The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related...The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related...

5):844-852. doi: 10.1093/rheumatology/kew499. Clinical Trial; Clinical Trial, Phase III; Comparative Study; Multicenter Study; ... The arachidonate 5-lipoxygenase activating protein gene polymorphism is associated with the risk of scleroderma-related ... The arachidonate 5-lipoxygenase activating protein (ALOX5AP) regulates synthesis of leukotrienes (LTs), which are important ... Kowal-Bielecka O1, Chwiesko-Minarowska S2, Bernatowicz PL2, Allanore Y3, Radstake T4,5, Matucci-Cerinic M6, Broen J5, ...
more infohttps://phgkb.cdc.gov/PHGKB/phgHome.action?action=forward&dbsource=huge&id=178781

Frontiers | Neutrophil Heterogeneity in Cancer: From Biology to Therapies | ImmunologyFrontiers | Neutrophil Heterogeneity in Cancer: From Biology to Therapies | Immunology

Arachidonate 5-Lipoxygenase (Alox5) Inhibition. Evidences showed that neutrophil-derived leukotriene support breast cancer ... Pharmacologic inhibition of arachidonate 5-lipoxyenase (Alox5) by zileuton (203) could inhibit the pro-metastatic activity of ... Zileuton: the first 5-lipoxygenase inhibitor for the treatment of asthma. Ann Pharmacother. (1996) 30:858-64. doi: 10.1177/ ... 5. Borregaard N. Neutrophils, from marrow to microbes. Immunity. (2010) 33:657-70. doi: 10.1016/j.immuni.2010.11.011 ...
more infohttps://www.frontiersin.org/articles/10.3389/fimmu.2019.02155/full

ALOX5AP Gene - GeneCards | AL5AP Protein | AL5AP AntibodyALOX5AP Gene - GeneCards | AL5AP Protein | AL5AP Antibody

Arachidonate 5-Lipoxygenase Activating Protein, including: function, proteins, disorders, pathways, orthologs, and expression. ... Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty ... arachidonate 5-lipoxygenase activating protein,expressed in cells of myeloid origin,localized in the nuclear envelop,involved ... There are six lipoxygenase isozymes; 5-LOX, 12R-LOX, 12S-LOX, 15-LOX-1, 15-LOX-2 and E-LOX. ...
more infohttps://www.genecards.org/cgi-bin/carddisp.pl?gene=ALOX5AP

Compound Report CardCompound Report Card

Arachidonate 5-lipoxygenase inhibitor Arachidonate 5-lipoxygenase PubMed PubMed PubMed Cyclooxygenase inhibitor Cyclooxygenase ... InChI=1S/C7H7NO3/c8-4-1-2-6(9)5(3-4)7(10)11/h1-3,9H,8H2,(H,1 ... Download InChI ...
more infohttps://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL704

Compound Report CardCompound Report Card

Arachidonate 5-lipoxygenase Homo sapiens 0.686 CHEMBL1945 Melatonin receptor 1A Homo sapiens 0.507 ...
more infohttps://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL154

Roflumilast - WikipediaRoflumilast - Wikipedia

InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22 ... 38 (5): 847-56. doi:10.1111/j.1365-2222.2008.02950.x. ISSN 1365-2222. PMID 18307529.. ...
more infohttps://en.wikipedia.org/wiki/Roflumilast

Gene Ontology ClassificationsGene Ontology Classifications

arachidonate 5-lipoxygenase. MGI:87999 Go Annotations as Summary Text (Tabular View) (GO Graph). Automated description from the ... Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).. Go Annotations in Tabular Form (Text View) (GO Graph) Filter ... Predicted to have arachidonate 5-lipoxygenase activity and iron ion binding activity. Involved in leukotriene biosynthetic ...
more infohttp://www.informatics.jax.org/go/marker/MGI:87999

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of...Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of...

Conversely, alternative activation resulted in the up-regulation of the M2 marker arachidonate 15-lipoxygenase and unexpectedly ... Differential regulation of arachidonate metabolism-related enzymes in human macrophage differentiation and polarization. A, ... as well as the arachidonate 5-lipoxygenase (ALOX5), and leukotriene A4 hydrolase. As expected, classical activation was ... arachidonate 5-lipoxygenase; COX, cyclooxygenase; Mo, monocyte; Mφ, macrophage. ...
more infohttps://www.jimmunol.org/content/177/10/7303?ijkey=da36007d28ed936f1f16880664e9d74353d8aaf3&keytype2=tf_ipsecsha

View the content page [c]View the content page [c]

Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
more infohttp://www.let.rug.nl/~gosse/termpedia2/termpedia.php?language=dutch_general&density=7&link_color=000000&termpedia_system=perl_db&url=http%3A%2F%2Fen.wikipedia.org%2Fwiki%2FAclidinium%2Fformoterol

Gene Expression Literature Summary - MGIGene Expression Literature Summary - MGI

arachidonate 5-lipoxygenase. MGI:87999 5 matching records from 5 references.. Summary by Age and Assay: Numbers in the table ...
more infohttp://www.informatics.jax.org/gxdlit/marker/MGI:87999

KEGG BRITE: KEGG Orthology (KO) - Falco peregrinus (peregrine falcon)KEGG BRITE: KEGG Orthology (KO) - Falco peregrinus (peregrine falcon)

101914238 ALOX5; arachidonate 5-lipoxygenase 101917252 LTA4H; leukotriene A4 hydrolase 101917253 leukotriene C4 synthase-like ... arachidonate 5-lipoxygenase [EC:1.13.11.34] K01254 LTA4H; leukotriene-A4 hydrolase [EC:3.3.2.6] K00807 LTC4S; leukotriene-C4 ... 101910798 GGT5; gamma-glutamyltransferase 5 101910629 GGT1; gamma-glutamyltransferase 1 101911072 GPX2; glutathione peroxidase ... 5; gamma-glutamyltranspeptidase / glutathione hydrolase / leukotriene-C4 hydrolase [EC:2.3.2.2 3.4.19.13 3.4.19.14] K00432 gpx ...
more infohttp://www.genome.jp/kegg-bin/get_htext?fpg00001+101919862

KEGG PATHWAY: hsa00590KEGG PATHWAY: hsa00590

ALOX12; arachidonate 12-lipoxygenase, 12S type [KO:K00458] [EC:1.13.11.31]. 242 ALOX12B; arachidonate 12-lipoxygenase, 12R type ... ALOX15B; arachidonate 15-lipoxygenase, type B [KO:K08022] [EC:1.13.11.- 1.13.11.33]. ... GPX5; glutathione peroxidase 5 [KO:K00432] [EC:1.11.1.9]. 493869 GPX8; glutathione peroxidase 8 (putative) [KO:K00432] [EC:1.11 ... GGT5; gamma-glutamyltransferase 5 [KO:K18592] [EC:3.4.19.14 3.4.19.13 2.3.2.2]. ...
more infohttps://www.genome.jp/dbget-bin/www_bget?pathway+hsa00590

Aminosalicylic Acid - DrugBankAminosalicylic Acid - DrugBank

Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some ... Sircar JC, Schwender CF, Carethers ME: Inhibition of soybean lipoxygenase by sulfasalazine and 5-aminosalicylic acid: a ... Allgayer H, Eisenburg J, Paumgartner G: Soybean lipoxygenase inhibition: studies with the sulphasalazine metabolites N- ... 2006 Dec;5(12):993-6. [PubMed:17139284] *Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug ...
more infohttps://www.drugbank.ca/drugs/DB00233

Bacteremia - Ontology Report - Rat Genome DatabaseBacteremia - Ontology Report - Rat Genome Database

arachidonate 5-lipoxygenase. 4. 148,398,004. 148,446,308. RGD:11554173. G. Apoa1. apolipoprotein A1. 8. 50,525,091. 50,526,875 ... 5. 82,587,424. 82,601,056. RGD:7241094. RGD:14697731. G. Tnf. tumor necrosis factor. 20. 5,189,382. 5,192,000. RGD:4891465. RGD ... C-C motif chemokine ligand 5. 10. 70,739,764. 70,744,303. RGD:2307171. G. Ccr1. C-C motif chemokine receptor 1. 8. 132,996,646 ... solute carrier family 38, member 5. X. 14,963,919. 14,972,675. RGD:9999227. G. Slpi. secretory leukocyte peptidase inhibitor. 3 ...
more infohttps://rgd.mcw.edu/rgdweb/ontology/annot.html?acc_id=DOID:9005036

Gene InfoGene Info

MF] arachidonate 5-lipoxygenase activity *[MF] iron ion binding *[MF] lipoxygenase activity *[MF] metal ion binding *[MF] ... BP] lipoxygenase pathway *[BP] oxidation-reduction process *[BP] positive regulation of vasoconstriction *[BP] sensory ...
more infohttps://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Mm&CID=41072&LLNO=11689

Resveratrol - DrugBankResveratrol - DrugBank

5,4-trihydroxystilbene) is a polyphenolic phytoalexin. It is a stilbenoid, a derivate of stilbene, and is produced in plants ... UArachidonate 15-lipoxygenase. Not Available. Humans. UArachidonate 5-lipoxygenase. Not Available. Humans. ... Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Involved in the constitutive ... Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some ...
more infohttps://www.drugbank.ca/drugs/DB02709
  • It was also found that the active 5-lipoxygenase metabolite, 5-oxoETE (a dehydrogenated derive of 5(S)-HETE), signals via its cognate receptor, called OXER1, which is a member of the seven-transmembrane G proteincoupled receptor (GPCR) family. (clinicsinoncology.com)
  • In (b), PKCε was first isolated from untreated LNCaP cells and then treated with 5-oxoETE or MK591 (10 μM) for 10 min in the assay buffer. (nih.gov)
  • Lipoxygenases (LOXs) are a family of non-heme iron dioxygenases that are involved in the production and metabolism of fatty acid hydroperoxidases. (genecards.org)
  • The risk or severity of adverse effects can be increased when Aminosalicylic Acid is combined with 5-androstenedione. (drugbank.ca)