The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)
The faculty of expressing the amusing, clever, or comical or the keen perception and cleverly apt expression of connections between ideas that awaken amusement and pleasure. (From Random House Unabridged Dictionary, 2d ed)
A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm.
A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.
Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
The pressure of the fluids in the eye.
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
The selectively permeable barrier, in the EYE, formed by the nonpigmented layer of the EPITHELIUM of the CILIARY BODY, and the ENDOTHELIUM of the BLOOD VESSELS of the IRIS. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.
Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
The front third of the eyeball that includes the structures between the front surface of the cornea and the front of the VITREOUS BODY.
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)
The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.
Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Measurement of ocular tension (INTRAOCULAR PRESSURE) with a tonometer. (Cline, et al., Dictionary of Visual Science, 4th ed)
Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of the iris, and constricted, sluggish pupil. Symptoms include radiating pain, photophobia, lacrimation, and interference with vision.
The removal of a cataractous CRYSTALLINE LENS from the eye.
The aperture in the iris through which light passes.
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
Single layer of large flattened cells covering the surface of the cornea.
A form of secondary glaucoma which develops as a consequence of another ocular disease and is attributed to the forming of new vessels in the angle of the anterior chamber.
Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.
Diseases affecting the eye.
One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.
A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.
The L-Isomer of bunolol.
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
Abnormally low intraocular pressure often related to chronic inflammation (uveitis).
A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.
A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.
An involuntary expression of merriment and pleasure; it includes the patterned motor responses as well as the inarticulate vocalization.
Any surgical procedure for treatment of glaucoma by means of puncture or reshaping of the trabecular meshwork. It includes goniotomy, trabeculectomy, and laser perforation.
Tumors or cancer of the EYE.
Introduction of substances into the body using a needle and syringe.
An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)
A colorless liquid with a fragrant odor. It is used as an intermediate, solvent and in cosmetics.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome.
The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.
Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.
Removal of an autonomic or sensory ganglion by any means.
Partial or total replacement of the CORNEA from one human or animal to another.
Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

Estimation of corneal endothelial pump function in long-term contact lens wearers. (1/1321)

PURPOSE: To study the effects of long-term contact lens wear on morphologic and physiologic properties of corneal endothelial cells. METHODS: The endothelial permeability to fluorescein and the rate of corneal deswelling from hypoxia-induced edema were measured in 20 long-term (mean, 17+/-9 years; range, 5-33 years) contact lens wearers and 20 age-matched control subjects. From these data, the relative endothelial pump rate in each subject was estimated, based on the pump-leak hypothesis of corneal hydration control. Corneal autofluorescence and the aqueous humor flow rate were determined by fluorescein fluorophotometry. Images of corneal endothelial cells were recorded by using specular microscopy, and morphologic indices (cell density, coefficient of variation of cell area, percentage of hexagonal cells, and skewness) were determined. RESULTS: No statistically significant differences were found between the contact lens and control groups in endothelial permeability, corneal deswelling, relative endothelial pump rate ([mean +/- SD] 1.07+/-0.33 relative pump units versus 1.01+/-0.25 relative pump units; contact lens versus control; P = 0.57), and endothelial cell density. Contact lens wearers had a significantly higher aqueous humor flow rate (3.57+/-1.03 microl/min versus 2.77+/-0.51 microl/min; P = 0.005), coefficient of variation of cell area (0.35+/-0.09 versus 0.28+/-0.04; P = 0.006), and corneal autofluorescence (3.1+/-0.6 ng/ml versus 2.3+/-0.3 ng/ml fluorescein equivalents; P < 0.001) than did non-contact lens wearers. CONCLUSIONS: Despite the known effects of long-term contact lens wear on corneal endothelial morphometry, no effect on endothelial function was found.  (+info)

Latrunculin-A increases outflow facility in the monkey. (2/1321)

PURPOSE: To determine the effect of Latrunculin (LAT)-A, a macrolide that binds to G-actin, which leads to the disassembly of actin filaments, on shape, junctions, and the cytoskeleton of cultured bovine aortic endothelial cells (BAECs) and on outflow facility in living monkeys. METHODS: Latrunculin-A dose-time-response relationships in BAECs were determined by immunofluorescence and phase contrast light microscopy, facility by two-level constant pressure anterior chamber perfusion. RESULTS: In BAECs, LAT-A caused dose- and incubation time- dependent destruction of actin bundles, cell separation, and cell loss. Cell-cell adhesions were more sensitive than focal contacts. Recovery was also dose- and time-dependent. In monkeys, exchange intracameral infusion and topical application of LAT-A induced dose- and time-dependent several-fold facility increases. The facility increase was completely reversed within several hours after drug removal. However, for at least 24 hours after a single topical LAT-A dose, perfusion with drug-free solution caused an accelerated increase in facility beyond that attributed to normal resistance washout. CONCLUSIONS: Pharmacological disorganization of the actin cytoskeleton in the trabecular meshwork by specific actin inhibitors like LAT-A may be a useful antiglaucoma strategy.  (+info)

Effect of staurosporine on outflow facility in monkeys. (3/1321)

PURPOSE: To determine the effect of the serine-threonine kinase inhibitor staurosporine on outflow facility in living monkeys. METHODS: Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber bilaterally before and after intracameral infusion of staurosporine or vehicle in opposite eyes. RESULTS: Intracameral staurosporine dose-dependently doubled outflow facility, with 0.1 microM, 1 microM, and 10 microM being subthreshold, effective, and maximal doses, respectively. At 50 microM, intracameral staurosporine was less effective than 10 microM on facility and induced corneal toxicity. CONCLUSIONS: The broad-spectrum protein kinase inhibitor staurosporine increases outflow facility in living monkeys, perhaps by affecting the trabecular meshwork cytoskeleton.  (+info)

Cytomegalovirus (CMV) retinitis activity is accurately reflected by the presence and level of CMV DNA in aqueous humor and vitreous. (4/1321)

To evaluate the potential of ocular and systemic specimens to provide markers of active cytomegalovirus (CMV) retinitis, we examined the relationship between virologic and clinical aspects of CMV infections in AIDS patients with CMV retinitis. CMV polymerase chain reaction (PCR) analysis of 74 aqueous humor and vitreous specimens indicated that ocular specimens can provide accurate markers to differentiate active and inactive CMV retinitis (aqueous or vitreous PCR, P<.001). Moreover, these markers were superior to extraocular measures, including plasma PCR (P=.08) and blood and urine CMV cultures (P=.05). A direct correlation was identified between the quantity of CMV DNA in aqueous humor or vitreous specimens and the corresponding surface area of active CMV retinitis (r2=.69 and.44, respectively). Thus, qualitative and quantitative PCR-based analyses of aqueous humor can provide valuable markers of CMV retinitis activity. Such assays could provide rapid and reliable tools to assist in management of patients with CMV retinitis in whom the view of the retina is obscured.  (+info)

High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice. (5/1321)

In order to investigate whether the p53 gene product plays a role in normal eye development, age matched p53-deficient mice and wild-type controls were sacrificed from day 2 to day 21 after birth. Eyes were paraffin-embedded and sectioned. Serial sections were taken at the level of the tunica vasculosa lentis and the hyaloid artery. The terminal dUTP nick-end labelling technique (TUNEL) was used to detect the number of cells displaying DNA fragmentation within these structures. Eyes were also prepared for scanning electron microscopy and resin embedded for semi-thin sections. Adult wild-type mice and p53-deficient mice were examined ophthalmoscopically in vivo. Ophthalmoscopical examination of mice completely deficient in p53 revealed them to be normal except for the persistence of the hyaloid vasculature, a structure that normally regresses during eye development. In adult animals there was also a high frequency of cataracts. Using morphological assessment and TUNEL we could show that in normal mice, regression of the primary vitreous, which includes the hyaloid artery, the vasa hyaloidea propria as well as the tunica vasculosa lentis, occurs via apoptotic cell death within 5 - 6 weeks after birth. The number of TUNEL-positive cells within these structures was significantly reduced in the p53-deficient mice in which parts of the hyaloid vasculature persisted and developed into a fibro-vascular retrolental plaque analogous to persistent hyperplastic primary vitreous (PHPV) described in humans. As in humans, PHPV in mice resulted in the development of cataracts. We have identified a role for p53-dependent apoptosis in the regression of the hyaloid vasculature and tunica vasculosa lentis. Our results provide further evidence for the importance of p53 in normal development and provide the first detailed evidence of its role in postnatal development in remodelling the developing eye.  (+info)

Electrical parameters of the isolated cornea of the dogfish, Squalus acanthias. (6/1321)

The electrical potential difference and electrical resistance of the nonswelling cornea of the dogfish, Squalus acanthias, were examined. It was found that routine procedures used in the procurement of fish invariably produce damage to the corneal epithelium which affects electrical measurements and possibly composition of the aqueous humor. We found no electrical evidence of ionic pumps in the corneal epithelium of this elasmobranch. The electrical resistance of corneas with apparently well-preserved epithelium was 300omega-cm.2 (compared to 30omega-cm.2 in corneas with damaged epithelium).  (+info)

Enthacrynic and acid effects on inner wall pores in living monkeys. (7/1321)

PURPOSE: The influence of the inner wall of Schlemm's canal on aqueous outflow facility remains poorly understood. We examined the relationship between inner wall pore characteristics and outflow facility in living primate eyes in which facility had been pharmacologically increased by ethacrynic acid (ECA) infusion and in contralateral control eyes. METHODS: Outflow facility (two-level constant pressure perfusion) was measured in eight pairs of living monkey eyes before and after administration of a bolus dose of either 0.125 mM ECA or vehicle. After exsanguination, eyes were fixed in situ under constant-pressure conditions (mean fixation pressure approximately 19 mm Hg). The density and diameter of inner wall pores and the number and area of platelet aggregates on the inner wall of Schlemm's canal were measured by scanning electron microscopy. RESULTS: In ECA-treated eyes, outflow facility increased 63% (P < 0.0001), intracellular pore density decreased 46% (P = 0.0094), intracellular pore size increased 27% (P = 0.049), platelet aggregate density increased 158% (P < 0.0001), and area covered by platelets increased 210% (P = 0.012) relative to contralateral controls. Although the average density and size of intercellular pores were essentially unaffected by ECA, an increased density of large (> or = 1.90 microm) intercellular pores was seen in ECA-treated eyes. The density of intracellular pores increased with the duration of fixative perfusion. Other than a weak negative correlation between outflow facility and intracellular pore density in ECA-treated eyes (P = 0.052), facility was not correlated with inner wall pore features. CONCLUSIONS: Our data are most consistent with a scenario in which ECA promotes formation of large intercellular pores in the inner wall of Schlemm's canal, which are then masked by platelet aggregates. Masking of intercellular pores, combined with fixation-induced alteration of inner wall pore density, greatly complicates attempts to relate facility to inner wall structure and suggests that in vivo pore density is smaller than in fixed tissue. Additionally, facility-influencing effects of ECA on the juxtacanalicular tissue cannot be excluded.  (+info)

Effect of aqueous humor on apoptosis of inflammatory cell types. (8/1321)

PURPOSE: To determine whether aqueous humor promotes cell death in cells involved in inflammatory responses. METHODS: Multiple immune cell types, most characteristically involved in inflammatory responses, were incubated for 24, 48, and 72 hours in the presence or absence of 50% aqueous humor. Promotion of cell death was assayed by staining for an early indicator of apoptosis. The percentage of cells undergoing apoptosis was measured by flow cytometry. To identify partially the apoptosis inducing factor, aqueous humor was pretreated with proteinase K to degrade protein. In other experiments, aqueous humor was fractionated by centrifugation on filters capable of separating molecules above and below 10 kDa or 30 kDa kilodaltons in size. RESULTS: Rabbit aqueous humor promoted apoptosis in a wide variety of immune cells, including lymphokine-activated natural killer cells, resting T cells, an activated T-cell line, RAW 264.7 and J774A0.1 monocyte-macrophage cell lines, and neutrophils. As previously shown, aqueous humor did not promote apoptosis of murine corneal endothelial cells. Apoptosis was also not induced in human corneal endothelium, mouse corneal epithelium, or iris/ciliary body cell lines. Instead, aqueous humor partially protected these ocular tissues from starvation-induced cell death. Pretreatment with proteinase K inhibited the apoptosis-inducing activity. Moreover, the apoptosis-inducing activity segregated with the aqueous humor fraction containing molecules less than than 10 kDa in size. CONCLUSIONS: These data show that aqueous humor contains a factor or factors that promote death of cells that participate in inflammatory processes. By contrast, ocular tissues, such as the corneal endothelium and iris/ciliary body, are impervious to aqueous humor-induced cell death. The aqueous humor- borne factor(s) may contribute to the immune privilege of the anterior chamber by purging potential inflammatory cells.  (+info)

Aqueous humour is continually produced by the ciliary processes and this rate of production must be balanced by an equal rate of aqueous humour drainage. Small variations in the production or outflow of aqueous humour will have a large influence on the intraocular pressure. The drainage route for aqueous humour flow is first through the posterior chamber, then the narrow space between the posterior iris and the anterior lens (contributes to small resistance), through the pupil to enter the anterior chamber. From there, the aqueous humour exits the eye through the trabecular meshwork into Schlemms canal (a channel at the limbus, i.e., the joining point of the cornea and sclera, which encircles the cornea[5]) It flows through 25-30 collector canals into the episcleral veins. The greatest resistance to aqueous flow is provided by the trabecular meshwork (esp. the juxtacanalicular part), and this is where most of the aqueous outflow occurs. The internal wall of the canal is very delicate and allows ...
Purine nucleotide degradation products have been determined by HPLC in aqueous humor obtained during cataract surgery and from plasma of 22 patients (12 women). Uric acid, cytosine, guanosine monophosphate, uracyl, guanine, adenosine, adenosine monophosphate, thymine, adenine, inosine, cyclic guanosine monophosphate, hypoxanthine and xanthine were evaluated. Uric acid and the last two were the only compounds detectable in measurable amounts in aqueous humor and in plasma of all patients. Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were lower than those of xanthine and than plasma oxypurine levels. In 8 patients, treated with allopurinol, oxypurinol concentrations in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor barrier.. ...
Synonyms for aqueous humor in Free Thesaurus. Antonyms for aqueous humor. 1 synonym for aqueous humor: aqueous humour. What are synonyms for aqueous humor?
TY - JOUR. T1 - Effects of ion transport and channel-blocking drugs on aqueous humor formation in bovine isolated eye. AU - Shahidullah, M.. AU - Wilson, W.S.. AU - Yap, Keng Hung Maurice. AU - To, Chi Ho. AU - Butt, C.. PY - 2002. Y1 - 2002. M3 - Journal article. VL - 43. JO - Investigative Ophthalmology. JF - Investigative Ophthalmology. SN - 0146-0404. IS - 13. M1 - 901. T2 - Association for Research in Vision and Ophthalmology (ARVO). Meeting. Y2 - 1 January 2002. ER - ...
Purpose: : Recent studies in our laboratory have demonstrated that nitric oxide plays a role in morphine-induced reduction of intraocular pressure and pupil diameter in New Zealand white (NZW) rabbits. The goal of the present study was to determine the effect of morphine on nitric oxide levels in the aqueous humor of NZW rabbits. Methods: : Normal, dark-adapted (reverse light cycle, 12/12 hr dark/light) NZW rabbit eyes were treated topically and bilaterally as follows: 1) morphine (100 µg) for 5 or 30 minutes; 2) 30 minute pretreatment with naloxone (100 µg; a nonselective opioid receptor antagonist) or L-NAME (0.5 %; a nitric oxide synthase inhibitor), followed by treatment with morphine for 5 or 30 minutes. Aqueous humor samples were obtained by paracenthesis and immediately assayed for nitric oxide (nitrites + nitrates) using a nitric oxide quantitation kit. Results: : The levels of NO in aqueous humor of rabbits treated with morphine for 5 minutes, increased from 34.22 ± 2.22 µM ...
Although the resistance to outflow, postoperatively, is probably dependent on the TDM,7 proponents of viscocanalostomy4 advocate tightly suturing the superficial flap in an attempt to avoid subconjunctival filtration. Whether tightly or loosely suturing the flap affects the overall outflow facility changes after NPGS has, to our knowledge, not been investigated before.. We report an in vitro mean preoperative outflow facility in isolated porcine eyes, in line with previously published work.11 The mean (SD) outflow facility after NPGS (1.584 (0.217) μl/min/mm Hg) is relatively lower than previously reported mean outflow facility after trabeculectomy11 (2.957 (0.602) μl/min/mm Hg), which possibly accounts for the gradual decrease in IOP after NPGS, as opposed to the sudden drop in pressure after penetration as in the case of trabeculectomy.. According to McEwen12 a single patent hole of 12 μm is by itself sufficiently large to provide a normal facility of outflow. Based on this we would have ...
Title: Aqueous Humor Pharmacokinetics of Dorzolamide Loaded PLGAChitosan Nanoparticles by Ultra Performance Liquid Chromatography. VOLUME: 7 ISSUE: 3. Author(s):Musarrat H. Warsi, Akash Chaurasiya, Gaurav K. Jain, Shadab A. Pathan, Prakash Chander, Ajeet K. Singh, Sushama Talegaonkar, Farhan J. Ahmad and Roop K. Khar. Affiliation:Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.. Keywords:Aqueous humor, Dorzolamide, Nanoparticles, Ocular pharmacokinetics, Ultra performance liquid chromatography, Ultraviolet (UV) detection, Ocular bioavailability, Limit of detection, Limit of quantification, Assay validation. Abstract: Ocular pharmacokinetic analysis of drugs is useful for evaluation of efficacy of novel ophthalmic formulations. A simple and sensitive ultra performance liquid chromatographic (UPLC) method with ultraviolet (UV) detection was developed and validated for the quantification of dorzolamide (DZA) in rabbit aqueous humor. The aqueous humor ...
Purpose: To look at the influence of aqueous humour protein content and viscosity, which may increase in anterior chamber inflammation, on equilibrium pressure under the scleral flap in trabeculectomies. The influence of suture numbers and scleral flap shapes was also investigated. Methods: Normal and uveitic aqueous humour were represented by plain BSS, BSS containing 300 mg/ 100 ml of albumin and BSS containing 3000 mg/ 100 ml of albumin. Porcine corneoscleral rims were mounted on a Barron artificial anterior chamber and chamber pressure was measured using a pressure transducer. 4 mm x 4 mm partial thickness scleral flaps and 0.75 mm diameter sclerostomies were created, followed by re-suturing of the flap with either 2 or 4 sutures, as in a trabeculectomy. Equilibrium pressure in the chamber was noted. The square scleral flaps were also compared with 4 mm x 3 mm rectangular and 4 mm x 4 mm triangular flaps. In all cases, n = 8. Statistical analysis involved the unpaired t-test and one-way ...
PURPOSE: To obtain aqueous humor and tear fluid samples during cataract surgery of the hepatitis C virus (HCV)-antibody-positive patients in order to analyze them for HCV RNA and compare these measurements with serum HCV RNA levels.. METHODS: Twenty-nine anti-HCV-positive patients were included this study. HCV RNA viral load levels were determined by commercial real-time polymerase chain reaction system. Antibodies to HCV were screened with the enzyme-linked immunosorbent assay (ELISA) using anti-HCV test kit.. RESULTS: Log10 HCV RNA levels were found to be 6.00 ± 1.06 IU/mL in serum, 2.76 ± 0.36 IU/mL in the aqueous humor, and 1.91 ± 0.93 IU/mL in tear fluid. No correlation was detected between samples for HCV RNA positivity (p = .390, κ = .102). We have observed that, viral RNA was detected in the aqueous humor, while not in serum in one case, whereas viral RNA was detected in tear fluid but not in serum in another case.. CONCLUSIONS: Although viral load detected in aqueous humor and tear ...
Looking for aqueous humour? Find out information about aqueous humour. Physiol the watery fluid within the eyeball between the cornea and the lens Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005 Explanation of aqueous humour
GALLARDO, C.; PAREDES, E. e PEREZ, J.. Histopathological study of canine liver and kidney and their relationship with blood and postmortem aqueous humour samples concentrations of urea, creatinine, proteins and enzymes activities (ALT and SAP). Arch. med. vet. [online]. 2003, vol.35, n.1, pp.61-74. ISSN 0301-732X. http://dx.doi.org/10.4067/S0301-732X2003000100006.. The goal of this study was to characterize histopathological lesions of the liver and kidney of canines, and their relationship with blood and postmortem samples of aqueous humor concentrations of urea, creatinine, proteins and ALT and SAP plasmatic activity. Thirty one animals were used in this study. They did not have clinical history of hepatic or renal diseases. Plasma samples were obtained before euthanasia. A sample of aqueous humor was obtained from the right eye of each dog just after euthanasia and a similar sample was obtained 24 hours later from the left eye. Urea, creatinine and protein concentrations and plasmatic ...
Experimental Eye Research, Vol: 127, Pages: 224-235, ISSN: 1096-0007 The bulk of aqueous humor passing through the conventional outflow pathway must cross the inner wall endothelium of Schlemms canal (SC), likely through micron-sized transendothelial pores. SC pore density is reduced in glaucoma, possibly contributing to obstructed aqueous humor outflow and elevated intraocular pressure (IOP). Little is known about the mechanisms of pore formation; however, pores are often observed near dome-like cellular outpouchings known as giant vacuoles (GVs) where significant biomechanical strain acts on SC cells. We hypothesize that biomechanical strain triggers pore formation in SC cells. To test this hypothesis, primary human SC cells were isolated from three non-glaucomatous donors (aged 34, 44 and 68), and seeded on collagen-coated elastic membranes held within a membrane stretching device. Membranes were then exposed to 0%, 10% or 20% equibiaxial strain, and the cells were aldehyde-fixed 5 min after ...
A pioneering dye-based technique that enables aqueous humour outflow to be studied has the potential to improve glaucoma angle-based procedures and surgery outcomes.
TY - JOUR. T1 - Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucoma. AU - Kim, Jaeryung. AU - Park, Dae Young. AU - Bae, Hosung. AU - Park, Do Young. AU - Kim, Dongkyu. AU - Lee, Choong Kun. AU - Song, Sukhyun. AU - Chung, Tae Young. AU - Lim, Dong Hui. AU - Kubota, Yoshiaki. AU - Hong, Young Kwon. AU - He, Yulong. AU - Augustin, Hellmut G.. AU - Oliver, Guillermo. AU - Koh, Gou Young. PY - 2017/10/2. Y1 - 2017/10/2. N2 - Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also ...
Glaucoma is a leading cause of blindness, with an estimated world-wide prevalence of 3.5% in members of the population older than 40 years of age. Elevated intraocular pressure as the result of abnormal resistance to aqueous humor drainage is a major contributing, and the only preventable, factor in glaucoma development. Schlemms canal (SC), a lymphatic-like vessel encircling the anterior portion of the eye, plays a key role in promoting aqueous humor outflow and maintenance of normal intraocular pressure. The risk of developing glaucoma increases with age; therefore, understanding mechanisms of SC maintenance and how aging affects SC function are of special importance, both for prevention and novel treatment approaches to glaucoma. Using a compelling array of genetic models, Kim et al. report in this issue of the JCI that continuous angiopoietin/TIE2 signaling is required for maintaining SC identity and integrity during adulthood and show that its age-related changes can be rescued by a TIE2 ...
Expression levels of 87 proteins were found to be different between glaucomatous and control aqueous humor. Of the 87 proteins, 34 were significantly upregulated, whereas 53 proteins were downregulated in the aqueous humor from glaucoma patients compared to controls. Differentially expressed proteins were found to be involved in cholesterol-related, inflammatory, metabolic, antioxidant as well as proteolysis-related processes.. CONCLUSION ...
In the anterior part of our eye there are two cavities filled with a watery but nutritive fluid called aqueous humor. One cavity, called the anterior chamber, lies just behind the cornea and in front of the iris. The other, called the posterior chamber, is a narrow space behind the iris and is surrounded by a mucsuloepithelial structure called the ciliary body. Aqueous humor is contiuously formed into the posterior chamber by the double layer ciliary epithelium that covers the ciliary body. Aqueous humor then sips through the hole at the center of iris, called the pupil, into the anterior chamber. Excess aqueous humor leaves the anterior chamber, by a pressure dependent way, mainly through a sieve-like structure called the trabecular meshwork located at the junction of the cornea and the sclera. Apart from supplying the nutrients and removing metabolic wastes from the avascular tissues of the eye, namely, the cornea, trabecular meshwork and the lens, the aqueous humor maintains the optimum ...
accommodation: ability of the lens to adjust its shape for vision at various distances in order to produce a clear image on the retina.. anterior chamber: space in front portion of the eye between the cornea and the iris and lens, which is filled with aqueous humor. aqueous humor: clear, watery fluid that fills the anterior chamber and the posterior chamber in the front part of the eye and provides nutrients to structures in the anterior chamber.. aqueous outflow pathway: the main exit route of aqueous humor from the eye, including the trabecular meshwork and Schlemms canal.. astigmatism: irregular curvature of the cornea or lens resulting in a distorted image because light rays are not focused on a single point on the retina.. binocular vision: coordinated use of the two eyes to see a single fused three-dimensional image.. blindspot: in testing the visual field, this is the blind area corresponding to the optic disk where the optic nerve fibers exit the eye and where there are no ...
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood. Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all hallmarks of POAG in humans. We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, ...
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood. Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all hallmarks of POAG in humans. We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, ...
Humour is often used to make light of difficult or stressful situations and to brighten up a social atmosphere in general. It is regarded by many as an enjoyable and positive experience, so it would be reasonable to assume that it might have some positive physiological effects on the body. A study designed to test the positive physiological effects of humour, the relationship between being exposed to humour and pain tolerance in particular, was conducted in 1994 by Karen Zwyer, Barbara Velker, and Willibald Ruch. To test the effects of humour on pain tolerance the test subjects were first exposed to a short humorous video clip and then exposed to the cold pressor test. To identify the aspects of humour which might contribute to an increase in pain tolerance the study separated its fifty-six female participants into three groups, cheerfulness, exhilaration and humour production. The subjects were further separated into two groups, high Trait-Cheerfulness and high Trait-Seriousness ac... ...
Relationship between the severity of macular edema and the aqueous humour concentrations of cytokines.A. IL-1β. B. IL-6. C. IL-8. D. IP-10. E. MCP-1. F. VEGF.
J Room Physiol 143:439В444 de Carvalho EF, de Castro FT, Rondinelli E, Carvalho JF (1994) Physiological aspects of Trypanosoma cruzi gene control during heat-shock. P2X4 receptors induced in spinal microglia barrier tactile allodynia after tenacity injury. 1 pct of men and 21 buy 5 mg proscar with visa prostate cancer questions. In its original 2 years, the GOG was in discus- sions with the Childrens Oncology Set (RATCHET) to col- laborate on a usage for the benefit of scrutiny inasmuch as low-risk disease and compressed BEP repayment for intermediate-risk disease. They like using toys in behalf of their intended tenacity as beyond the shadow of a doubt as for whatever invented ambition they can imagine. You pot motley this likewise cheap super cialis 80 mg free shipping erectile dysfunction medication australia. Peak aqueous humor concentrations of triamcinolone ranged from 2,151 to 7,202 ng/mL, half-life 76В635 h, and AUC0Вt 231 to 1,911 ng h/mL following celibate intravitreal ...
This study was conducted to investigate therapeutic value of a soluble tumor necrosis factor-alpha (TNF-alpha) receptor, etanercept, in a rat model of endotoxin-induced uveitis (EIU). Forty-two inbred male Lewis rats were divided into seven equal groups. 200 mug of Escherichia coli 055:1355 lipopolysaccharide, (LPS) was injected in one hind footpad of the Groups 2, 3, 4, 5, 6, and 7 rats. Group 5, 6, and 7 rats also received subcutaneous etanercept 24 hr prior to LPS injection at a dose of 0(.)4 mg kg(-1). Group 1 rats were used as controls. Eight, 24, and 48 hr after treatment clinical uvetis scores (miosis, iris hyperemia, and hypopyon) were assessed by a masked observer and the rats were euthanized. Neutrophil leukocytes, CD8 +, CD4 +, and CD45RO + cells in the anterior uveal tissue were counted either after hematoxylin-eosin or monoclonal antibody staining. TNF-alpha. levels were also measured in the aqueous humor samples by an ELISA method. Etanercept treatment significantly improved ...
Part of Leightons lecture will include teasing the humor out of the New Testament. The story in Matthew 8:28-34, in which Jesus drives demons out of two men and into a herd of pigs that immediately run off the edge of a cliff and drown, will be the conduit through which Leighton will explore the edge of humor. He said he likes using that story because humor is about exorcising our demons.. Humor can bring to light whats wrong with our society and can help us learn to laugh at ourselves, Leighton said, but it can also demean and denigrate people and kill compassion. Leighton, an ordained Presbyterian minister, said he cant make generalizations for all of Christianity.. (The lecture is) one Christians take on the challenges (of humor), Leighton said. Its Christian in the sense that Im trying to access resources within my own tradition to understand how humor works.. Leightons journey with studying interfaith humor began in 2013 when the ICJS decided to expand its educational mission ...
Glaucoma is a disease of the eye where there is an increase in the pressure within the eye, this is called the intraocular pressure. This disease can be quite painful and will often result in blindness. An increase in intraocular pressure is caused by the globe of the eye being unable to drain. Inside the eye is the ciliary body, this structure not only contains the ligaments that hold the lens in place and helps it focus it also produces aqueous humor. Aqueous humor is a fluid that provides nutrition to the eye, helps the eye maintain its shape due and provides the intraocular pressure of the eye. Aqueous humor is located in the anterior chamber of the eye which is the front most chamber between the cornea and the iris. This fluid is being constantly produced by the ciliary body, in order to maintain homeostasis in the eye it must drain at a commensurate rate. The area where drainage occurs is called the iridocorneal angle. When the eyes drainage of aqueous humor does not keep up with its ...
The most critical risk factor for optic nerve damage in cases of primary open-angle glaucoma (POAG)(31) is an increased intraocular pressure (IOP) due to alternation of tissues in the eye located around the base of the cornea(32). Actin, a critical player in many cellular functions, including cell motility and the maintenance of cell shape, etc.(33), disruption or taken over actin cytoskeleton by numerous pathogens(34), may induce a resistance to aqueous humor outflow in the trabecular meshwork (TM)(36), an area of tissue is responsible for draining the aqueous humor from the eye via the anterior chamber causes of optic nerve damage involved connective tissue growth factor (CTGF), found in higher amounts in the aqueous humor of patients with POAG(35 ...
Orientation: Using humour in diversity contexts may relieve tension temporarily, but it happens at the expense of someone and indicates a defence against an unconscious anxiety dynamic. Research purpose: The purpose of this research was to describe the manifestation of humour as a defence mechanism against diversity anxiety. Motivation for the research: In working with diversity dynamics in South African organisations, consultants and participants often do not take humour seriously, let alone interpret the accompanying dynamic aspects. Working below the surface with humour may elicit much more and typical diversity dynamics worth investigating. Research design, approach and method: The research design was qualitative and descriptive, using multiple case studies and content analysis. Main findings: Humour is used as a defence against the anxiety experienced in diversity contexts caused by fear of the unknown within the self and the projection of the fear onto another identity group. ...
Its not just what we say that matters, but how we say it when it comes to building a great, safe culture, said Kerr. Humour makes people more approachable; it helps build connections and relationships and break down walls. Humour not only helps messages stand out, relevant humour reduces the counter-argument part of the brain - that part of peoples brains where they immediately start building arguments about why they are not going to do something - so people are more accepting of a message, said Kerr.. If you deliver a message, a rule, a regulation, a safety policy with a little bit of humour, studies show people are five times more likely to go along with you if you do it in a funny way, he said.. Some ways to do this are by using a top 10 list, opening with a funny story, using humour in safety videos - just doing something to add a little bit of humour into the mix.. We need to make sure we are coming up with creative opportunities to share our messages in more fun ways so we are truly ...
WGA#One is your gateway to the World Glaucoma Association. With a WGA#One account you can access knowledge resources and join our community ...
Trabeculectomy is a surgical procedure recommended for patients with glaucoma that continues to progress despite use of medications and/or laser treatments and to relieve intraocular pressure by removing part of the eyes trabecular meshwork and adjacent structures. It is the most common glaucoma surgery performed and allows drainage of aqueous humor from within the eye to underneath the conjunctiva where it is absorbed. This provides an alternative method of aqueous humor filtration when the natural trabecular outflow pathway is blocked or poorly functioning. This outpatient procedure is performed under topical.. ...
Disclaimer: This is a medical humor and parody website meant solely for entertainment purposes, and is not intended to recommend or advise regarding the prevention, diagnosis, or treatment of any medical illness or condition. Stories and articles are meant only to provide a brief, fleeting distraction from the wretchedness of reality, and are not intended to be insensitive, callous, or offensive, or to otherwise belittle the plight of those affected with any medical disease, condition, or illness. All names and descriptions of people are fictitious except for those of well-known public figures, who are the subject of satire. Any resemblance to actual persons or events is purely coincidental. Medical Humor is just that: Medical Humor.. ...
Objectives Improve understanding of positive and negative humor. Increase knowledge of how humor affects our physical, psychological and social wellbeing. Focus on the use of humor for persons with Short Term Memory Loss, and their caregivers. Set out techniques to improve utilization of humor and exposure to humor in daily life. Laugh and tell a few illustrative jokes.
The Short Humour (Humor) Site aims to promote the reading and writing of Short Humour (Humor) both in Britain and throughout the world and also to showcase work by writers of the genre.
Synonyms for cardinal humours in Free Thesaurus. Antonyms for cardinal humours. 54 synonyms for humour: comedy, funniness, fun, amusement, funny side, jocularity, facetiousness, ludicrousness, drollery, comical aspect, mood, spirits, temper. What are synonyms for cardinal humours?
Genetic heterogeneity of primary open-angle glaucoma, and concentration changes of various inflammation and immune response mediators in the blood, aqueous humor or tissues, indicate the involvement of different genetic mechanisms and immune system activity in the pathogenesis of POAG. The aim of study was to determine the interdependent clinical, genetic and biochemical findings in POAG-HTG patients. Distribution of genetic polymorphisms for TNF-α -308 G/A and - 863 C/A in DNA samples was examined using PCR-RFLP, the concentrations of circulating TNF-α and HSP 70 in a plasma and concentration of sFas and sFasL in the aqueous humor were measured by commercial ELISA tests. Their association with quantitative clinical parameters was examined. This study included 357 subjects: 81 POAG-HTG, 35 PEXG, 77 with senile cataract and 164 healthy subjects age-sex matched. Furthermore, 35 samples of aqueous humor of POAG-HTG patients , 24 PEXG and 29 with senile cataract were treated. The results s...howed ...
Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye
Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemms canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemms canal.
The healthy eye is filled with a clear fluid called aqueous humor which circulates inside the front portion of your eye. Your eye continually produces a small amount of aqueous humor while an equal amount flows out of your eye in order to maintain a constant healthy eye pressure. Glaucoma means that the aqueous humor is not flowing out of your eye properly and that pressure in the eye is building up. This pressure can cause damage to your optic nerve over time.. Early detection is key with glaucoma. People of any age with glaucoma symptoms or glaucoma risk factors, such as diabetes, family history of glaucoma, or those of African descent, should see an ophthalmologist regularly.. ...
Thank you for visiting us at the Childrens Humor Study!. We would like to invite you and your child to consider participation in an exciting new research study to increase our understanding of the development of humor.. In this study we aim to examine the brain development and function, specifically as it relates to cognition and humor. We are currently seeking typically-developing children (ages 6-12) who are native English-speakers. For more information about our research findings related to humor in adults, please read our labs publications. If you are interested in learning more abour our current study, please read through this website.. Study Goals:. This study is directed by Drs. Allan Reiss (Stanford University) and Jessica Black (Boston College). The goals of the study are to:. ...
The aqueous humor is a clear fluid that maintains the integrity of the eye. It is produced by the ciliary body and passes through the trabecular meshwork and Schlemms canal. Intraocular pressure (IOP) is determined by the amount of aqueous humor secreted, coupled with the rate of clearance from the eye. An elevated IOP leads to optic nerve deterioration and associated irreversible functional vision loss.[1][2]
We report here the results of our experience with the use of PCR for the identification of T. gondii in blood and aqueous humor samples from patients with and without ocular toxoplasmosis. Currently, the clinical diagnosis of ocular toxoplasmosis is based on the observation of a necrotizing lesion on the fundus, response to treatment, and serologic determination. However, in cases of atypical retinitis or when the fundus is hidden by vitreal inflammation, establishment of a diagnosis by ophthalmological examination alone can be difficult. In such cases the aqueous humor analysis may be used as a diagnostic tool for confirmation of ocular toxoplasmosis. Determination of intraocular production of antitoxoplasmic antibodies has been performed previously, but the results obtained had erratic values (2, 21). PCR has mostly been used to detect T. gondii in different biological samples (4, 9, 12, 14,19). Aqueous humor samples from patients with ocular toxoplasmosis have also been used with the PCR ...
Aim: The aim of the study was to compare selenium levels in plasma and aqueous humour in subjects with and without primary open-angle glaucoma (POAG).. Methods: Forty-seven POAG cases and 54 controls in this case-control study were recruited from surgery patients at the University Physicians Ophthalmology Clinic in Tucson, Arizona, USA. Aqueous humour and plasma selenium were determined by high-performance liquid chromatography ion channel plasma mass spectrometry (HPLC ICP-MS). Potential confounders were assessed via a questionnaire. Biological samples were collected and processed at surgery and analysed for selenium content after collection was complete. Outcome measures included the odds of glaucoma in relationship to plasma selenium, aqueous humour selenium, and the ratio of levels of aqueous humour selenium to plasma selenium.. Results: Tertile of selenium and its relationship to POAG was examined. After adjustment for common glaucoma risk factors, the odds of glaucoma in the highest ...
Background: To evaluate the ability of topical ibopamine 2% to detect outflow resistance by comparing it with the tonography test in eyes with ocular hypertension (OHT). Methods: 62 eyes with OHT and 33 control eyes were included in this prospective study. Tonography was done manually as a standard outflow facility measurement. We used a C value of 0.18 mu l/min/ mm Hg or less and a P-o/C value of 100 and above as a positive tonographic test. The ibopamine test performed on the following day was considered positive if there was an intraocular pressure (IOP) change of at least 3 mm Hg. Results: The sensitivity of the tonography and ibopamine tests was 69 and 53%, respectively, in eyes with OHT. The specificity of both tests was 97%. Although the sensitivity of the tonography test is higher than that of the ibopamine test, the difference between both was not statistically significant in these eyes ( p = 0.409). Positive results in tonography were associated with higher IOP, while the results were ...
TY - JOUR. T1 - Significant variation of the elevated nitric oxide levels in aqueous humor from patients with different types of glaucoma. AU - Tsai, Der Chong. AU - Hsu, Wen-Ming. AU - Chou, Ching Kuang. AU - Chen, Shih Jen. AU - Peng, Chi Hsien. AU - Chi, N. Wen. AU - Ho, Larry L.T.. AU - Liu, Jorn Hon. AU - Chiou, Shih Hwa. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Though several studies have shown that the biochemical function of nitric oxide (NO) in the eye might play an important role in the regulation of intraocular pressure (IOP), local control of ocular blood flow and loss of retinal ganglion cells by apoptosis, it is unclear whether the role of NO is similar in the pathogenesis of different kinds of glaucoma: primary open-angle glaucoma (POAG), chronic closed-angle glaucoma (CCAG) and neovascular glaucoma (NVG). To further explore this issue, we measured the concentrations of NO in aqueous humor and plasma samples from patients with POAG (n = 31 ), CCAG (n = 76), NVG (n = 8) and cataract (n ...
Aqueous humor flows regularly from posterior chamber to anterior chamber, and this flow much involves intraocular pressure, the eye tissue nutrition and metabolism. To visualize and measure the intraocular flow regular pattern of aqueous humor. Intraocular flow in the vitro eyeball is driven to simulate the physiological aqueous humor flow, and the flow field is measured by Particle Image Velocimetry(PIV). Fluorescent particle solution of a certain concentration was infused into the root of Posterior Chamber(PC) of vitro rabbit eye to simulate the generation of aqueous and was drained out at a certain hydrostatic pressure from the angle of Anterior Chamber(AC) to represent the drainage of aqueous. PIV method was used to record and calculate the flow on the midsagittal plane of the eyeball. Velocity vector distribution in AC has been obtained, and the distribution shows symmetry feature to some extent. Fluorescent particle solution first fills the PC as it is continuously infused, then surges into AC
In our study, 2PM was used to image the trabecular drainage channels of intact enucleated rat eyes. Due to the intrinsic properties of drainage tissue, autofluorescence from collagen fibers can be used to image the microstructure of the pathway. Compared to external fluorescent label, autofluorescence can avoid tissue damage caused by fluorochrome. Meanwhile, 2PM is suited to tissue imaging under the sclera, and has been successfully used to image living skin at a depth of 350 μm by visualizing the 2PAF of the skins extracellular matrix and melanin [19]. Most importantly of all, we were able to successfully get the high resolution images under high scattering tissue of eye. Our imaging had a lateral resolution of 2 μm, and a depth resolution of 1 μm. It is found that the high resolution imaging can achieve resolution of tissue section, and can avoid tissue distortions caused by infusion of fixatives.. Aqueous humor drains into aqueous vein through TM region firstly. In this progress, TM and ...
The major risk factor for most glaucomas and focus of modeling and treatment is increased intraocular pressure. Intraocular pressure is a function of production of liquid aqueous humor by the ciliary body of the eye and its drainage through the trabecular meshwork. Aqueous humor flows from the ciliary bodies into the posterior chamber, bounded posteriorly by the lens and the zonule of Zinn and anteriorly by the iris. It then flows through the pupil of the iris into the anterior chamber, bounded posteriorly by the iris and anteriorly by the cornea. From here the trabecular meshwork drains aqueous humor via Schlemms canal into scleral plexuses and general blood circulation. In open angle glaucoma there is reduced flow through the trabecular meshwork; in angle closure glaucoma, the iris is pushed forward against the trabecular meshwork, blocking fluid from escaping ...
Interest in the linguistics of humor is widespread and dates since classical times. Several theoretical models have been proposed to describe and explain the function of humor in language. The most widely adopted one, the semantic-script theory of humor, was presented by Victor Raskin, in 1985. Its expansion, to incorporate a broader gamut of information, is known as the General Theory of Verbal Humor. Other approaches are emerging, especially in cognitive and corpus linguistics. Within applied linguistics, the predominant approach is analysis of conversation and discourse, with a focus on the disparate functions of humor in conversation. Speakers may use humor pro-socially, to build in-group solidarity, or anti-socially, to exclude and denigrate the targets of the humor. Most of the research has focused on how humor is co-constructed and used among friends, and how speakers support it. Increasingly, corpus-supported research is beginning to reshape the field, introducing quantitative concerns, as well
Our image of Roman satire has developed from that of a static, moralizing genre to a deliberately complex form, but our approach to the humour intrinsic to satire has not developed accordingly. This book offers a comprehensive new analysis of humour in the writings of Horace, Persius, and Juvenal, with an excursus to Lucilius. The main thesis is that far from being an external means of sweetening the moral lesson, humour lies at the heart of Roman satire and shapes its paradoxical essence. The book argues that while the satirist needs humour for the aesthetic merit of his work, his ideological message inevitably suffers from the ambivalence that humour carries. By analyzing object-oriented humour, humour directed at the speaker (including self-irony), and humour directed at neither object nor subject, the book shows how the Roman satirists work round this double mission of morals and merriment. As a result, they present the reader with a much more sprawling and open literary product than they promise
Glaucoma still represents the most frequent cause of irreversible blindness worldwide. The technological advances lead to innovative surgeries, which are rapidly introduced in clinical practice. New devices to lower intraocular pressure without opening the eye wall, bypassing the trabecular meshwork, or shunting the aqueous humor to the suprachoroidal space have been approved undergoing clinical assessment within clinical trials. Currently, other devices under evaluation are showing promising results. Although these methods will increase the options available for glaucoma surgeons, it is unclear if they could replace the present standard surgeries, such as trabeculectomy, deep sclerectomy, and glaucoma drainage devices. Moreover, the standard procedures are continuously modified in different ways to become safer and more effective. In this issue L. Choritz et al. investigate whether increased concentrations of endothelin-1 in the aqueous humor samples of glaucoma patients influenced wound healing and
Read Isoforms of TGF-β in the aqueous humor of patients with pseudoexfoliation syndrome and a possible association with the long-term stability of the capsular bag after cataract surgery, Graefe
Mathematical models to describe drug concentration profiles of topically administered drug in the anterior chamber aqueous humor have been proposed by several authors. The aim of this paper is to present a mathematical model to predict the drug concentration in the anterior chamber when a therapeutical contact lens with the drug is entrapped in nanoparticles is used ...
The FM-700 aqueous flare meter (also known as a Laser Flare Meter) enhances the follow up of patients by enabling the in-vivo measurement of aqueous flare in a non-contact, non-invasive and painless manner. The quantitative and reproducible measurement of aqueous flare it provides is known to be useful in cases of uveitis and following IOL implantation, and increased levels of flare have been reported with many other ocular conditions. This latest generation of the Kowa aqueous flare meter has been designed to combine the ultimate in efficiency and accuracy providing fast detection of ocular inflammation and subclinical change of inflammation levels ...
Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A device and method are provided for improved treatment of elevated intraocular pressure due to glaucoma. A trabecular shunting device is adapted for implantation within the trabecular meshwork of an eye such that aqueous humor flows controllably from the anterior chamber of the eye to Schlemms canal, bypassing the trabecular meshwork. The trabecular shunting device may utilize a quantity of pharmaceuticals effective in treating glaucoma, which are controllably released from the device into cells of the trabecular meshwork and/or Schlemms canal. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular shunting device such that aqueous flow either increases or decreases as desired. Placement of the trabecular shunting device within the eye, and release of a glaucoma medication therefrom, can arrest or slow the progression of glaucoma.
This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone
GLAUCOMA Should you be targeting collector channels with MIGS? by Liz Hillman Editorial Co-Director Targeting an area with increased pigmentation and blood reflux into Schlemms canal (red line) adjacent to a blue mark on the cornea (black line) that identified a collector channel Source: Paul Harasymowycz, MD With newer stenting devices bypassing the trabecular meshwork or
ធម្មតា ការផលិតទឹកក្នុងភ្នែករបស់យើង (Aqueous humour) ចាប់ផ្តើមចេញពីគល់ប្រស្រីភ្នែក (Ciliary body) ដែលជាកន្លែងផលិត បន្ទាប់មកវាហូរមកបន្ទប់ផ្នែកខាងក្រោយ រួចបន្តមកបន្ទប់ភ្នែកខាងមុខ ហើយត្រូវបានស្រូបចេញតាមចម្រោះ Trabecular Meshwork និងបន្តចេញមកតាម បំពង់តូច (Schlemms canal) ហើយចុងបញ្ចប់ជ្រាបតាមសរសៃវ៉ែន (Episcleral vein) ...
Looking for Humor, Vampire? Find out information about Humor, Vampire. Mel Brookss Dracula: Dead and Loving It is a prime example of vampire humor. Leslie Neilsen played the hapless Count Dracula. Legendary Dracula actor... Explanation of Humor, Vampire
A new study shows that patients with glaucoma or ocular hypertension (OHT) and recurrent anterior uveitis have a reduced tonographic outflow-lower than patients without glaucoma or OHT-but an actual aqueous flow that is not statistically any different from patients without glaucoma or OHT. Researchers from St. Thomas Hospital in London divided 92 patients into three groups. Group one had patients with recurrent anterior uveitis (three or more attacks) and were being treated for glaucoma or OHT. Group two patients had experienced previous recurrent anterior uveitis without glaucoma or OHT. The third group, the controls, had no ocular problems and IOP less than 21mm Hg. They found that the tonographic outflow facility was approximately 0.18 in group one, 0.25 in group two and 0.27 in the control group. However, the aqueous flow rate in group one was 2.47μl/min, in group two it was 2.13μl/min and 2.25μl/min in the control. The investigators say this demonstrates that the elevated IOP seen in the ...
Of all cases with positive PCR for the herpes virus family in intraocular samples taken between 2007 and 2016, only those with VZV and HSV1 or HSV2 met the criteria for ARN. None of the 12 patients with CMV, one patient with EBV and one patient positive for both viruses, exhibited signs of ARN clinically, which is in keeping with Takase et al.6 Some authors suggest EBV and CMV as possible causes.3 4 19 These viruses usually affect immunocompromised patients and typically have a different clinical picture. Lau et al as well as Hillenkamp et al reported that patients with ARN who tested EBV positive with PCR also were positive for VZV.20 21 Low levels of EBV in conjunction with high levels of VZV has also been reported in cerebrospinal fluid in viral CNS disease.15 In this material, we did not find positivity for multiple viruses in the same sample as none of patients with ARN had CMV DNA in intraocular fluids and the four samples analysed for EBV DNA were also negative. The hypothesis that ARN is ...
Contemporary research began investigating the physiology and therapeutic effects of humor and in fact some believe that humor accomplishes the same goal as physical exercise. Some humor -laughter research findings are as follows:1. Humor experience leads to arousal of the sympathetic nervous system 2.Epinephrine is a precondition for physiological arousal 3. Arousal as measured by heart rate and skin conduction increases with the intensity of the response to something humorous 4. Laughter increases respiration, oxygen exchange, muscular activity, heart rate , stimulates the cardiovascular system , the sympathetic nervous system and the production of catecholamine 5. Blood-pressure is also reduced in a state similar to that resulting from exercise. 6. Increases in systolic and a diastolic blood-pressure is related to the intensity and length of the laughter .Blood pressure levels decreased after laughter to below pre-laughter levels.7 There is greater coordination of function between the right ...
Jul 24, 2019 - Old age finds us all. It creeps up when we are not expecting it and takes us by surprise, leaving us wondering what is next. Sometimes we are able to look back and see the wisdom, and the humor, of our journey. See more ideas about humor, bones funny, senior humor.
The Kahook Dual Blade (KDB) is an single-use ophthalmic blade with a micro-engineered profile which allows for insertion into the eye through a clear cornea micro-incision. It can be done with or without cataract surgery, and when done in conjunction with cataract surgery it is done following lens removal through the same incision utilized for the cataract removal. The device is made of surgical grade stainless steel body with a long, thin shaft that allows for access across the anterior chamber to the trabecular meshwork (TM). Using a special mirrored lens, the surgeon uses the Kahook Dual blade to make parallel incisions in the trabecular meshwork (TM), un-roofing it and opening up into inner wall of the Canal of Schlemm to improve aqueous humor outflow from the eye in an effort to reduce the eye pressure. This procedure does not involve opening up the conjunctival tissues; this is a major advantage of this procedure as it makes future glaucoma surgery (if needed) a lot simpler with less risk ...
Treatment for glaucoma is directed at restoring both vision and comfort. This requires an accurate assessment of the extent and duration of the pressure elevation. In eyes which have the potential for return of functional vision (no globe enlargement, duration less than one week), immediate medical therapy is used to initially reduce the pressure. This is followed by a choice of surgical options to attempt to permanently normalize the pressure. Medical management is rarely successful long-term due to recurrent pressure elevation and drug toxicity.. The diode laser is used to treat glaucoma through photocoagulation of the ciliary body. A 1 mm probe is applied to the sclera 2-2.5 mm posterior to the limbus to deliver 2.5-3.5 joules (2.5 mwatts for 1000-1400 msec) of energy to the ciliary body over 20-30 sites. This results in localized destruction of the secretory epithelium of the ciliary body thus reducing aqueous humor production. There is also some increase in extrascleral outflow of aqueous ...
Posterior chamber is an important structure involved in production and circulation of aqueous humor. Aqueous humor produced by ... "Flow of Aqueous Humor". yale. Harpreet Gill, MD Staff Physician, Henry Ford Ophthalmology (Sep 20, 2018). "Phacomorphic ... The block in flow of aqueous from the posterior to the anterior chamber will lead to a condition known as Iris bombe. In this ... Surgical management of Glaucoma due to Iris bombe include making a small hole in the iris which allows passage of aqueous from ...
Brubaker RF (1991). "Flow of aqueous humor in humans". Invest Ophthalmol Vis Sci. 32 (13): 3145-3166. PMID 1748546. Hashemi H, ... the rate of aqueous humour formation in microliters per minute (μL/min) U {\displaystyle U} the resorption of aqueous humour ... During the night, intraocular pressure may not decrease despite the slower production of aqueous humour. In the general ... Intraocular pressure is determined by the production and drainage of aqueous humour by the ciliary body and its drainage via ...
... a part of the uveoscleral outflow pathway for aqueous humor. The uveoscleral pathway is an important pathway for aqueous ... Aqueous humor is produced in the portion of the eye known as the ciliary body. The ciliary body contains 72 protrusions known ... The trabecular outflow is one of the major outflow pathways for aqueous humor in the eye and has been the target of both ... Toris CB (2008). "Chapter 8: Aqueous Humor Dynamics II - Clinical Studies". Current Topics in Membranes. Heine L (1905). "Die ...
Add arteries and veins, aqueous humor, corneosclera. Resize tendons. Redraw ora serrata. ... Vitreous humor with 19. Hyaloid canal/(old artery), 20. Retina with 21. Macula or macula lutea, 22. Fovea and 23 Optic disc → ... 1. Lens, 2. Zonule of Zinn or Ciliary zonule, 3. Posterior chamber and 4. Anterior chamber with 5. Aqueous humour flow; 6. ...
Vitreous humor Vitreous detachment Aqueous humor Sobotta, Johannes (2011). Sobotta : atlas of human anatomy (15th ed.). München ... This chamber is filled with a thick, clear gel-like substance called the vitreous humor (also vitreous body). The humor plays a ... The vitreous chamber is the space in the eye occupied by vitreous humor. Within the vertebrate eye, there are considered to be ...
Winkler, NS; Fautsch, MP (2014). "Effects of prostaglandin analogues on aqueous humor outflow pathways". Journal of Ocular ... and subsequent studies found that this was due to increasing the outflow of aqueous humor, mainly by relaxing the ciliary ...
Metabolism of angiotensin I by guinea pig aqueous humor. Can J Physiol Pharmacol 2001;79:627-30. Igić R, Behnia R. Properties ...
Eye surgery Glaucoma surgery Brubaker, Richard F. (1991-12-01). "Flow of Aqueous Humor in Humans [The Friedenwald Lecture]". ... Foo VH, Htoon HM, Welsbie DS, Perera SA (2019). "Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma". ... are transscleral implants to channel aqueous humor into the non-dissected Tenon's space, creating a subconjunctival drainage ... due to the ongoing scarring over the conjunctival dissipation segment of the shunt may become too thick for the aqueous humor ...
Dortch-Carnes J, Russell K (2007). "Morphine-stimulated nitric oxide release in rabbit aqueous humor". Exp. Eye Res. 84 (1): ...
... aqueous humor, or sputum. Stimulating light excites an electron, raising energy to an unstable level. This instability is ...
Toris, C. B.; Tafoya, M. E.; Camras, C. B.; Yablonski, M. E. (1995). "Effects of Apraclonidine on Aqueous Humor Dynamics in ...
Scar formation at the site of excision or operation may block aqueous humor circulation, while healthy tissue regeneration will ... Certain cells within the eye's ciliary body produce aqueous humor. A ciliary destructive or cyclodestructive procedure is one ... that facilitate the escape of excess aqueous humor from the eye to lower intraocular pressure, and a few that lower IOP by ... A surgical goniotomy involves cutting the fibers of the trabecular meshwork to allow aqueous fluid to flow more freely from the ...
... is a circular lymphatic-like vessel in the eye that collects aqueous humor from the anterior chamber and ... On the inside of the canal, nearest to the aqueous humor, it is covered by the trabecular meshwork; this region makes the ... greatest contribution to outflow resistance of the aqueous humor. Conventionally, the canal has been considered a blood vessel ... delivers it into the episcleral blood vessels via aqueous veins.[1][2][3][4] It is named after Friedrich Schlemm (1795-1858), a ...
When applied to the eye it works by decreasing the amount of aqueous humor made while increasing the amount that drains from ... Toris CB, Camras CB, Yablonski ME (July 1999). "Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular ... This vasoconstriction may explain the acute reduction in aqueous humor flow. The increased uveoscleral outflow from prolonged ... This reduces cAMP and hence aqueous humour production by the ciliary body. Peripheral α2 agonist activity results in ...
"Distribution of flunixin meglumine and firocoxib into aqueous humor of horses". Journal of Veterinary Internal Medicine. 25 (5 ...
Clinic on aqueous humor pathology. L'humeur aqueuse et ses fonctions, (with Marc Amsler and Alfred Huber, 1955) - Aqueous humor ... He was the author of 74 medical papers, many of which concerned the eye's aqueous humor. He was also interested in uveitis; in ...
Additional measures include paracentesis of aqueous humor to decrease IOP acutely. An ESR should be drawn to detect possible ...
... enables the aqueous humor to circulate. When the animal is sleeping, REM provides the much-needed stir to aqueous humor. This ... he calculated that if aqueous humor was stagnant, oxygen from iris had to reach cornea by diffusion through aqueous humor, ... and that aqueous humor, the liquid between cornea and iris, was stagnant if not stirred.[105] Among the supportive evidences, ...
So ibopamine can not be found in the aqueous humor after instillation. After being hydrolysed to epinine, ibopamine is able to ... It has been shown that the half-life of ibopamine is short to about 2 minutes in the aqueous humour owing to the fast ... Due to the esterases existing in the aqueous humour and ocular tissues, ibopamine can be rapidly hydrolysed to epinine which is ... In some randomized clinical trials, the D1 dopaminergic activity of ibopamine led to an increased production of aqueous humour ...
The endothelium is a single cell layer that separates the cornea from the aqueous humor. ... There may also be signs of anterior uveitis, such as miosis (small pupil), aqueous flare (protein in the aqueous humour), and ...
The vitreous does not undergo a regular formation and drainage process like the aqueous humor. Instead, it stays permanently in ... aqueous humour) which is continuously replenished, the gel in the vitreous chamber is stagnant. Therefore, if blood, cells or ... "Encyclopædia Britannica from Encyclopædia Britannica 2006 Ultimate Reference Suite DVD 2009 The Vitreous Humor Archived April ...
It is the most common glaucoma surgery performed and allows drainage of aqueous humor from within the eye to underneath the ... Intraocular pressure may be lowered by allowing drainage of aqueous humor from within the eye to the following routes: (1) ... Various adjunctive devices have been used with trabeculectomy, to maintain drainage of aqueous humor and to maintain the ... Glaucoma medications are usually discontinued to improve aqueous humor flow to the bleb. Topical medications consist typically ...
Detection of herpes simplex virus in aqueous humor in iridocorneal endothelial (ICE) syndrome. Cornea. 1999;18(3):359-360. [6] ...
Aqueous Humor Formation/Outflow] + Episcleral Venous Pressure. This equation states that free-flowing aqueous humor should ... aqueous humor can pass more freely into collector channels and aqueous veins. The Goldmann equation states that Intraocular ... The Ttrabecular meshwork is a major site of resistance to aqueous humor outflow. As angle surgeries such as Trabectome follow ... 2016) Aqueous outflow regulation: Optical coherence tomography implicates pressure-dependent tissue motion. Exp Eye Res. https ...
... which produces the aqueous humor. The aqueous humor is produced in the non-pigmented portion of the ciliary body. The ciliary ... and these secrete aqueous humor into the posterior chamber. The aqueous humor then flows through the pupil into the anterior ... Eighty percent of aqueous humor production is carried out through active secretion mechanisms (the Na+K+ATPase enzyme creating ... Because the ciliary body produces aqueous humor, it is the main target of many medications against glaucoma. Its inhibition ...
5α-Dihydrocortisol is present in the aqueous humor of the eye, is synthesized in the lens, and might help make the aqueous ... "5 alpha-dihydrocortisol in human aqueous humor and metabolism of cortisol by human lenses in vitro". Invest. Ophthalmol. Vis. ... humor itself.[39] 5α-Dihydroaldosterone is a potent antinatriuretic agent, although different from aldosterone. Its formation ...
The buildup of protein clumps can block normal drainage of the eye fluid called the aqueous humor and can cause, in turn, a ... The eye produces a clear fluid called the aqueous humor which subsequently drains such that there is a constant level of safe ... and improve the outflows of the aqueous humor. These can be done as an outpatient procedure and take less than twenty minutes. ... and removes a tiny area of the trabecular meshwork which enables the aqueous humor to discharge. This lowers the internal ...
... on aqueous humor dynamics in rabbits". Current Eye Research. 39 (8): 813-22. doi:10.3109/02713683.2013.874444. PMID 24502505. ... drug that reduces IOP by stimulating the movement of aqueous humour from the ciliary body away from the eye. It is a selective ...
"Active transforming growth factor-beta2 is increased in the aqueous humor of keratoconus patients". Molecular Vision. 13: 1198- ...
The H+ is then exchanged for sodium (Na) which allows you to make aqueous humor. By blocking carbonic anhydrase, the Na/H ... which will decrease Na in the cell and prevent aqueous humor production. This drug, developed by Merck, was the first drug in ... It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humour. Dorzolamide was approved for ...
Medications that lower intraocular pressure work by decreasing aqueous humor production and/or increasing aqueous humor outflow ...
"Vitreous and Aqueous Humor". *↑ Ali & Klyne 1985, p. 8 *↑ "Human eye". Encyclopædia Britannica. பார்த்த நாள் 20 November 2012. ...
Detachment is occasionally caused by contracture of fine collagenous fibrils in the vitreous humor, which pull areas of the ...
Thickening agents, or thickeners, are substances which, when added to an aqueous mixture, increase its viscosity without ... The ocular Vitreous humor is subject to rheologic observations, particularly during studies of age-related vitreous ...
Veselovský J, Oláh Z, Veselá A, Gressnerová S (2001). "[The pH reaction in aqueous humor to antiglaucoma agents of various ... either through increased production or decreased outflow of aqueous humour.[6] Increased resistance to outflow of aqueous ... Wikimedia Commons has media related to Aqueous humour.. *. "Anatomy diagram: 02566.000-1". Roche Lexicon - illustrated ... From there, the aqueous humour exits the eye through the trabecular meshwork into Schlemm's canal (a channel at the limbus, i.e ...
... and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue ...
Glaucoma [16][21](As eye drops, they decrease intraocular pressure by lowering aqueous humor secretion.[22]) ...
The pneuma mixes with a preexisting aqueous humor, filling up the uvea and causing the stretches observed within the pupil. If ...
"Morphine-stimulated nitric oxide release in rabbit aqueous humor". Exp. Eye Res. 84 (1): 185-90. PMC 1766947. PMID 17094965. ...
Since the cornea has no blood vessels (it takes its nutrients from the aqueous humor) it heals much more slowly than a cut on ...
Examples of this fluid are cerebrospinal fluid, aqueous humor in the eye, serous fluid in the serous membranes lining body ...
It is the most common glaucoma surgery performed and allows drainage of aqueous humor from within the eye to underneath the ... Intraocular pressure may be lowered by allowing drainage of aqueous humor from within the eye to the following routes: (1) ... Various adjunctive devices have been used with trabeculectomy, to maintain drainage of aqueous humor and to maintain the ... Glaucoma medications are usually discontinued to improve aqueous humor flow to the bleb. Topical medications consist typically ...
If the clear aqueous humor from the eye runs through the yellow stain, the patient tests positive for corneal perforation. ... Any aqueous leakage is revealed during the Seidel test confirms corneal perforation. A fluorescence strip is wiped over the ...
In the theory of the four bodily humors, water was associated with phlegm, as being cold and moist. The classical element of ... To observe the fundamental stretching absorption spectrum of water or of an aqueous solution in the region around 3500 cm−1 ( ... In industry, near-infrared spectroscopy is used with aqueous solutions as the greater intensity of the lower overtones of water ... calcium fluoride is one material that is in common use for the cuvette windows with aqueous solutions. ...
... aqueous humor, reproductive organs, and bone; highest concentrations occur in pleural fluid, interstitial fluid, peritoneal ...
... is made up of connective tissue and bathed in lacrimal fluid and aqueous humor, which provides it nutrition, as it does not ...
... openings located on either side of the collarette that allow the stroma and deeper iris tissues to be bathed in aqueous humor. ... Just in front of the root of the iris is the region referred to as the trabecular meshwork, through which the aqueous humour ... The iris along with the anterior ciliary body provide a secondary pathway for aqueous humour to drain from the eye. ...
... and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane ...
In a healthy cornea, endothelial cells keeps the tissue from excess fluid absorption, pumping it back into the aqueous humor. ...
... which were microfilariae moving freely in the aqueous humor of the anterior chamber of the eye. Blacklock and Strong had ...
... "humor and pathos, nihilism and the hope for redemption fight to the death inside Liddiard's voice as his mates [...] carry him ... aqueous world in sprawling, dense garage-blues epics". A similar point was made by Mark Abraham of Cokemachineglow, who ...
Aqueous humor cytokine profiling in patients with wet AMD.. Liu F1, Ding X1, Yang Y1, Li J1, Tang M1, Yuan M1, Hu A1, Zhan Z1, ... Undiluted aqueous humor samples (100-200 μl) were obtained from 16 wet AMD eyes and 12 control eyes. Forty chemokines were ... Compared with the control group, the aqueous humor in wet AMD patients showed a significantly higher expression of CXCL10 (p= ... To investigate the chemokine expression profiles in the aqueous humor of wet age-related macular degeneration (wet AMD) ...
... the aqueous humor is drained.. Consistently with the laws of physics, the aqueous humor contained in the chamber with the ... aqueous humor can circulate from the concave lower part towards the convex upper part, creating two spaces of aqueous humor to ... Aqueous humor drainage device. US4750901. Mar 5, 1987. Jun 14, 1988. Molteno Anthony C B. Implant for drainage of aqueous ... Glaucoma aqueous humor drainage plate. EP0168201A1. Jun 27, 1985. Jan 15, 1986. Neil Howard Joseph. Aqueous humour drainage ...
This study finds that aqueous humor from retinoblastoma eyes contains tumor-derived DNA that can be analyzed as an alternative ... Aqueous humor biopsy may be an improvement over existing methods, as it could require less advanced technical skills and carry ... Evaluation of aqueous humor demonstrated tumor-derived, cell-free DNA and regions of chromosomal gains and losses, representing ... This study finds that aqueous humor from retinoblastoma eyes contains tumor-derived DNA that can be analyzed as an alternative ...
Detection, quantification, and signficance of basic fibroblast growth factor in the aqueous humor of man, cat, dog and pig ... Human Hepatocyte Growth Factor (HGF) in the Aqueous Humor * * ARAKI SASAKI Kaoru ... Presence of human epidermal growth factor, basic fibroblast growth factor in human aqueous 並木真理 ...
... sheds light on the importance of understanding aqueous outflow at a fundamental level and discusses aqueous humor outflow ... Huang comments on how aqueous angiography facilitates surgeons ability to place surgerie… ... sheds light on the importance of understanding aqueous outflow at a fundamental level and discusses aqueous humor outflow ... sheds light on the importance of understanding aqueous outflow at a fundamental level and discusses aqueous humor outflow ...
Proteomic analysis of aqueous humor from patients with myopia. Xiaoming Duan,1 Qingjun Lu,2 Peng Xue,3 Hongjie Zhang,3 Zhe Dong ... Protein content in aqueous humor from patients and controls. The mean total protein level in AH from patients with high myopia ... Aqueous Humor in Primary Open-Angle Glaucoma Contains an Increased Level of CD44S. Invest Ophthalmol Vis Sci. 2002; 43:133-9. [ ... Sakamoto T, Ito S, Yoshikawa H, Hata Y, Ishibashi T, Sueishi K, Inomata H. Tissue factor increases in the aqueous humor of ...
Lidocaine concentration was measured in aqueous humor samples taken before surgery. RESULTS: With 3 drops, aqueous lidocaine ... Aqueous humor lidocaine concentrations in topical and intracameral anesthesia. Behndig, Anders Umeå University, Faculty of ... PURPOSE: To assess aqueous humor lidocaine concentrations in 2 common regimens of topical anesthesia and after intracameral ...
Aqueous Humor / metabolism*. Biological Assay. Cataract / etiology, metabolism, pathology. Cells, Cultured. Ciliary Body / ... Furthermore, aqueous humor from canine eyes with cataracts also contained significantly higher levels of TGF-beta 2 than normal ... Surprisingly, aqueous humor from aphakic rabbit eyes contained significantly higher levels of TGF-beta 2 than their ... METHODS: Lens and ciliary body epithelial cell culture supernatants and aqueous humors were assayed for total TGF-beta 2 levels ...
Notrox has vast experience in handling human aqueous humor sample analysis by liquid chromatography (LC)and mass spectrometry ( ... White Papers Human Aqueous Humor Sample Analysis Notrox Research Human Aqueous Humor Sample Analysis. 19 October 2017 Share ...
Absorption of Brimonidine Ophthalmic Solution in the Aqueous Humor of Cataract Patients. The safety and scientific validity of ... Absorption of Brimonidine Ophthalmic Solution in the Aqueous Humor of Cataract Patients.. ... The aqueous humor concentration 45 minutes following dosing of 0.1% Brimonidine Purite™ (pH 7.8) is comparable with 0.15% ... The purpose of this study is to obtain and assay human aqueous samples following pre-operative dosing with 0.1% Brimonidine ...
Metabolomics of the aqueous humor in patients with primary congenital glaucoma. Xueli Chen,1 Yuhong Chen,1 Li Wang,1 Xinghuai ... Ji Y, Rao J, Rong X, Lou S, Zheng Z, Lu Y. Metabolic characterization of human aqueous humor in relation to high myopia. Exp ... Barbas-Bernardos C, Armitage EG, García A, Mérida S, Navea A, Bosch-Morell F, Barbas C. Looking into aqueous humor through ... Amino acid pattern in human aqueous humor of patients with senile cataract and primary open-angle glaucoma. Ophthalmic Res. ...
Quantitative Analyses of Cytomegalovirus Genome in Aqueous Humor of Patients with Cytomegalovirus Retinitis * * ANDO Yasutaka ... Aqueous and vitreous humor samples for the diagnosis of cytomegalovirus retinitis MITCHELL SM ... An improved technique for the diagnosis of retinitis from samples of aqueous humor and vitreous GARWEG J ... Use of polymerase chain reaction assays of aqueous humor in the differential diagnosis of retinitis in patients infected with ...
This study evaluates aqueous humor levels of ET-1 and retrobulbar hemodynamics in patients with exfoliation syndrome (XFS) and ... Aqueous humor samples obtained at the beginning of cataract surgery were analyzed with enzyme-linked immunosorbent assay. ... Conclusion: ET-1 aqueous levels in eyes with XFG were significantly higher than those of age-matched controls. Reduced blood ... Retrobulbar hemodynamics and aqueous humor levels of endothelin-1 in exfoliation syndrome and exfoliation glaucoma Stavroula C ...
Circadian Rhythms of Aqueous Humor Dynamics When Using Brimonidine in Humans With Ocular Hypertension. The safety and ...
... a time when aqueous humor production is naturally low, will require measurement of all variables of aqueous humor dynamics ... Circadian Variation of Aqueous Dynamics in Young Healthy Adults. In Vivo Assessment of Aqueous Humor Dynamics Upon Chronic ... Circadian Variation of Aqueous Humor Dynamics in Older Healthy Adults Cherie B. Nau; Mehrdad Malihi; Jay W. McLaren; David O. ... Aqueous Humor Flow Rate, μL/min Outflow Facility, μL/min/mm Hg EVP, mm Hg Uveoscleral Outflow, μL/min ...
... are present in human aqueous humor.. Methods: Undiluted aqueous humor samples were collected from 10 patients who underwent ... Poly-Unsaturated Fatty Acids in Human Aqueous Humor You will receive an email whenever this article is corrected, updated, or ... Results: The analysis of ten samples of aqueous humor demonstrated the presence of the omega-6 fatty acid linoleic acid (LA), ... Conclusions: We demonstrate the presence of omega-3 and omega-6 PUFAs in human aqueous humor. The omega-6 fatty acid, linoleic ...
... ... Methods40 consecutive cases of TRC with a positive aqueous humour (AH) tap for toxoplasmosis were retrospectively included. ...
... and TNF-β in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal ... Aqueous humor was obtained at a different time point in the FLACS and corneal paracentesis groups. This was unavoidable due to ... The aqueous humor was assayed to determine the concentrations of cytokines using the FlowCytomix human Th1/Th2 11-plex BMS810FF ... Others have shown that concentrations of IL-1β, IL-6, and PGE2 in aqueous humor increase during FLACS compared to controls.5. ...
Since the aqueous humor passes directly into the venous system, the normal drainage process for aqueous humor is restored. ... may be connected to any source of aqueous humor, including the anterior chamber ( 1 ), an aqueous collector channel, Schlemms ... within the tissues of the eye to directly connect a source of aqueous humor such as the anterior chamber ( 1 ), to an ocular ... The invention provides minimally invasive microsurgical tools and methods to form an aqueous humor shunt or bypass for the ...
For blood and aqueous humor samples, 5 ml of anticoagulated blood and a 200- to 300-μl portion of aqueous humor, respectively, ... We report here the results of our experience with the use of PCR for the identification of T. gondii in blood and aqueous humor ... 1993) Detection of Toxoplasma gondii in aqueous humor by the polymerase chain reaction. Br. J. Ophthalmol. 77:107-109. ... The PCR was positive for 8 of the 15 blood samples and 7 of the 15 aqueous humor samples from patients in group 1. No ...
... Jpn J Ophthalmol. ... out of the effects of the lens wear on the mitosis in the corneal epithelium and the lactate concentration in the aqueous humor ... The contact lens wear suppressed the mitosis and increased the concentration of aqueous lactate, the degree of changes being ...
Aqueous Humor Outflow Imaging and the Clinic. Clinically, aqueous humor outflow and its segmental nature may play a role in ... For AHO, aqueous humor is actually made up of many components [66]. Predominately, aqueous humor is composed of water ( ... Figure 2: Aqueous angiography visualizes segmental aqueous humor outflow. Aqueous angiography was performed in the postmortem ... Figure 1: The Conventional Aqueous Humor Outflow Pathway. (A) Angle and aqueous humor outflow pathways can be visualized by ...
Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility. David Soto, Jesus ... Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility. David Soto, Jesus ... Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility. David Soto, Jesus ... Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility ...
Aqueous Humor: The Eyes Trabecular Meshwork 2.0 - 3D model by INTERVOKE (@intervoke) [0db7a0c] ... and is responsible for draining the aqueous humor from the eye via the anterior chamber. This fluid flows through the narrow ... Aqueous Humor: The Eyes Trabecular Meshwork 2.0. Your model is disabled. For more details go to Edit properties ... and is responsible for draining the aqueous humor from the eye via the anterior chamber. This fluid flows through the narrow ...
All aqueous humor (AqH) samples were tested for total protein concentration, ability to suppress in vitro T-cell activation, ... Aqueous humor reflects the microenvironment of the anterior chamber, and displays attributes that correlate with the immune ... We wished to determine whether immune privilege parameters assayed in aqueous humor are relevant to the fate of penetrating ... Immune privilege parameters assayed in aqueous humor prior to and after penetrating keratoplasty to correlate with graft ...
Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ... Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ... Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ... Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ...
Aqueous humor (100-200 μl) was aspirated from each patient by means of limbic paracentesis with the use of 30 gauge needle ... The research was to evaluate cytokine profile in aqueous humor of congenital cataract with PCD to search the pathogeny of PCD. ... Yinying Zhao, pingjun chang, Zhangliang Li, Xixia Ding, Yun-e Zhao; Cytokine profile in aqueous humor of congenital cataract ... Higher preoperative levels of TGFβ2, IL-6, VEGF in aqueous humor were associated with posterior capsule defect, which indicated ...
Penetration of Topically Administered 0.5-Percent Caspofungin Eye Drops into Human Aqueous Humor. Chin Fen Neoh, Lok Leung, ... During surgery, aqueous humor (50 to 150 μl) was collected through a paracentesis site using a 30-gauge needle before ... Aqueous humor concentrations of topically administered caspofungin in rabbits. Ophthalmic Res. 41:102-105. ... Ten participants gave consent (Table 1). The aqueous humor caspofungin concentrations for Arm 1 and Arm 2 were 28.9 to 95.1 ng/ ...
Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes ... Association of varicella zoster virus load in the aqueous humor with clinical manifestations of anterior uveitis in herpes ...
Ding W, Ni W, Chen H, Yuan J, Huang X, Zhang Z, Wang Y, Yu Y, Yao K. Comparison of Drug Concentrations in Human Aqueous Humor ... Keywords: aqueous humor, levofloxacin, gatifloxacin, ophthalmic gel, ophthalmic solution This is an open access article ... Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% ... Conclusions: 0.3% gatifloxacin ophthalmic gel application produced highest aqueous humor drug concentration, maintained the ...
  • This study will compare aqueous humor dynamics in adults with primary open angle glaucoma that receive Selective Laser Trabeculoplasty (SLT). (clinicaltrials.gov)
  • Undiluted aqueous humor samples were collected from 10 patients who underwent either elective cataract surgery and/or non-elective glaucoma surgery. (arvojournals.org)
  • The invention provides minimally invasive microsurgical tools and methods to form an aqueous humor shunt or bypass for the treatment of glaucoma. (google.com)
  • Glaucoma is a disease condition of the eye in which increased intraocular pressure (IOP) is created by dysfunction in the drainage mechanism for the aqueous humor. (google.com)
  • Typically in open angle glaucoma, the pathway for aqueous humor becomes narrowed or occluded, increasing IOP and resulting in gradual nerve damage and loss of vision. (google.com)
  • Product Details for The Eye's Aqueous Humor: From Secretion to Glaucoma by Civan, Mortimer M. (textbookx.com)
  • To determine the change in aqueous humor interleukin-6 (IL-6) levels among primary open-angle glaucoma (GPAA) patients. (elsevier.es)
  • Changes to the Aqueous Humor Proteome during Glaucoma. (physiciansweekly.com)
  • To investigate the aqueous humor proteome in patients with glaucoma and a control group. (physiciansweekly.com)
  • Aqueous humor was obtained from five human donors diagnosed with primary open angle glaucoma (POAG) and five age- and sex-matched controls undergoing cataract surgery. (physiciansweekly.com)
  • Of the 87 proteins, 34 were significantly upregulated, whereas 53 proteins were downregulated in the aqueous humor from glaucoma patients compared to controls. (physiciansweekly.com)
  • Glaucoma leads to profound changes to the aqueous humor proteome consistent with an altered metabolic state, an inflammatory response and impaired antioxidant defense. (physiciansweekly.com)
  • Purpose: To analyze changes in concentrations of pro- or anti-inflammatory cytokines, chemokines, or metalloproteinases (MMP) in the aqueous humor (AH) in Fuchs uveitis syndrome (FUS) patients with (FUSwG) or without (FUSwoG) secondary glaucoma. (uni-koeln.de)
  • If the aqueous humor is not removed rapidly enough or the eye fills too rapidly, pressure builds up in the eye, which can result in glaucoma. (freethesaurus.com)
  • This study was aimed to analyze the profile of vascular and inflammatory cytokines in aqueous humor of primary open angle glaucoma (POAG) patients. (researchsquare.com)
  • The identification of key cytokines, which function by increasing the permeability properties of cellular barriers, will open up a new therapeutic approach to treat glaucoma by promoting the outflow of aqueous through the trabecular or conventional aqueous outflow pathway. (grantome.com)
  • CONCLUSIONS Monitoring decay of fluorescence provides a noninvasive index of aqueous humor dynamics in the mouse eye that facilitates study of ocular hypotensive drugs and mouse models of glaucoma. (scienceexchange.com)
  • Purpose: The study aimed to evaluate and correlate between the levels of vascular endothelial growth factor (VEGF) in serum and aqueous humor in cases of neovascular glaucoma (NVG) to stand up on if it can be used as a marker for early detection of such cases. (scirp.org)
  • Learn what aqueous humor means and how the flow of this fluid can cause glaucoma disease. (brightfocus.org)
  • Therapies for glaucoma are aimed at lowering eye pressure by increasing the outflow of aqueous humour from the eye and decreasing its production by the ciliary body. (britannica.com)
  • Problems with the aqueous fluid can lead to issues involving the eye's pressure, such as glaucoma . (verywellhealth.com)
  • Glaucoma occurs if the aqueous humor is not removed rapidly enough or if it is made too rapidly, causing pressure to build-up. (encyclopedia.com)
  • In narrow-angle glaucoma, the angle where aqueous fluid drainage occurs is narrow, and therefore may drain slowly or may be at risk of becoming closed. (encyclopedia.com)
  • Central corneal thickness (CCT) is known to be associated with onset and progression of glaucoma and can potentially influence the individual parameters of aqueous humor dynamics that maintain IOP. (nebraska.edu)
  • The results demonstrate the first lentiviral vector transduction of the nonhuman primate aqueous humor outflow pathway and support application of the system to human glaucoma gene therapy. (elsevier.com)
  • The source of aqueous fibronectin is still not clearly known and the mechanism of the higher concentration of fibronectin in glaucoma has not been clearly disclosed, however it is thought that normally present fibronectin is accumulated in the anterior chamber because it can not pass the aqueous outflow pathway, or that fibronectin production may be increased in glaucoma . (bvsalud.org)
  • Surgical management of Glaucoma due to Iris bombe include making a small hole in the iris which allows passage of aqueous from posterior chamber to anterior chamber either by YAG or Argon laser iridotomy or by manual iridectomy. (wikipedia.org)
  • The aqueous humor normally flows through a network of tissues at the interior angle of the anterior chamber, named the trabecular meshwork and subsequently into a circular drainage space named Schlemm's canal. (google.com)
  • This volume present a basic consensus of how the aqueous humor is formed and exits through the trabecular meshwork and canal of Schlemm. (textbookx.com)
  • Traditional investigation drawn to the trabecular meshwork now emphasizes the entire conventional aqueous humor outflow (AHO) pathway from the anterior chamber to the episcleral vein. (omicsonline.org)
  • The trabecular meshwork is an area of tissue in the eye located around the base of the cornea, near the ciliary body, and is responsible for draining the aqueous humor from the eye via the anterior chamber. (sketchfab.com)
  • The compound has demonstrated the ability to lower intraocular pressure by stimulating aqueous humor outflow via trabecular meshwork through an activation of adenosine A2a receptor. (freethesaurus.com)
  • Aqueous humor flows from the ciliary body into the anterior chamber, out through a spongy tissue at the front of the eye called the trabecular meshwork and into a drainage canal (dark blue region next to the trabecular meshwork). (brightfocus.org)
  • As it circulates, the aqueous fluid flows to the front part of the eye, where it is drained by the trabecular meshwork , a sponge-like filtering system located where the cornea and iris meet. (visionaware.org)
  • After draining through the trabecular meshwork, the aqueous fluid then passes through a small duct, called the canal of Schlemm , and is absorbed into the bloodstream. (visionaware.org)
  • Aqueous humour leaves the eye through the porous trabecular meshwork and flows into Schlemm's canal , a ringlike passageway around the outer angle of the anterior chamber in front of the iris. (britannica.com)
  • Physiologically, aqueous humor (AH) of the eye is secreted by the ciliary process, flows through posterior chamber and pupil, enters anterior chamber, and exits the eye via the trabecular meshwork at last. (hindawi.com)
  • Intraocular pressure is determined by the production and drainage of aqueous humour by the ciliary body and its drainage via the trabecular meshwork and uveoscleral outflow. (wikipedia.org)
  • METHODS: Lens and ciliary body epithelial cell culture supernatants and aqueous humors were assayed for total TGF-beta 2 levels by ELISA and bioassay. (biomedsearch.com)
  • Aqueous humor is produced within the eye in the ciliary body and flows within the anterior region of the eye. (google.com)
  • 3. Aqueous is secreted by ciliary processes. (steadyrun.com)
  • Intraocular pressure remains normal when some of the fluid (aqueous humor) produced by the eye's ciliary body flows out freely (follow blue arrow). (brightfocus.org)
  • Aqueous humour is formed from the blood by filtration, secretion, and diffusion through the ciliary body, a muscular structure located behind the iris that controls the curvature of the lens. (britannica.com)
  • The uveal tract includes the ciliary body, the structure in the eye that releases a clear liquid called the aqueous humor. (verywellhealth.com)
  • Aqueous humor produced by the epithelium of the ciliary body is secreted into the posterior chamber, from which it flows through the pupil to enter the anterior chamber. (wikipedia.org)
  • an inner diameter of between 0.3 mm and 0.4 mm and sufficient length to position the anterior end in the anterior chamber of the eye and the rear end having a size which fits within an area covered by a perimeter of the cover, located in the intrascleral space for drainage of the aqueous humor. (google.com)
  • Have corneal abnormalities that would interfere with the ability to obtain an adequate sample safely or have a shallow anterior chamber which would make obtaining an aqueous sample difficult at the time of surgery in the opinion of the investigator. (clinicaltrials.gov)
  • The invention enables surgical creation of a tissue tract ( 7 ) within the tissues of the eye to directly connect a source of aqueous humor such as the anterior chamber ( 1 ), to an ocular vein ( 4 ). (google.com)
  • The tissue tract ( 7 ) from the vein ( 4 ) may be connected to any source of aqueous humor, including the anterior chamber ( 1 ), an aqueous collector channel, Schlemm's canal ( 2 ), or a drainage bleb. (google.com)
  • Aqueous humor reflects the microenvironment of the anterior chamber, and displays attributes that correlate with the immune privileged nature of this site. (egms.de)
  • Purpose: To evaluate cytokine expression profile in aqueous humor and sera in patients with HLAB27 associated acute anterior uveitis (AAU) and idiopathic AAU. (eurekaselect.com)
  • Diagnostic utility of aqueocentesis and aqueous humor analysis in dogs and cats with anterior uveitis. (escholarship.org)
  • OBJECTIVE:To evaluate diagnostic utility of aqueous humor analysis in animals with anterior uveitis. (escholarship.org)
  • Although aqueous humor contained predominantly neutrophils in cats with FIP and large reactive lymphocytes and plasma cells appeared more frequent in cats with idiopathic uveitis, neither clinical nor cytologic assessment of anterior chamber contents differed significantly between cats with idiopathic or FIP-associated uveitis. (escholarship.org)
  • CONCLUSIONS:Aqueous humor cytology permitted diagnosis of neoplasia in dogs with anterior uveitis but was generally not helpful in cats. (escholarship.org)
  • It was developed in collaboration with the University of Miami's Bascom Palmer Eye Institute, and it provides a quick and simple method of shunting aqueous humor from the anterior chamber to a diffuse bleb without the need for a scleral flap. (freethesaurus.com)
  • Aqueous humour , optically clear, slightly alkaline liquid that occupies the anterior and posterior chambers of the eye (the space in front of the iris and lens and the ringlike space encircling the lens). (britannica.com)
  • Trabeculectomy diverts aqueous humour from the anterior chamber inside the eye to the space under the conjunctiva (the transparent skin that covers the white area, or sclera, of the eye). (britannica.com)
  • Aqueous humor was aspirated from human eyes with cataracts and glaucomas using a 26 gauge needle through the peripheral cornea before making the limbal incision into the anterior chamber during surgery . (bvsalud.org)
  • The block in flow of aqueous from the posterior to the anterior chamber will lead to a condition known as Iris bombe. (wikipedia.org)
  • The surgery involves removing a small piece of the white, outer shell of the eye, to create a channel through which the aqueous humor fluid can flow. (freethesaurus.com)
  • show that the production of the ABTS radical cation in the presence of human aqueous humor follows lag phase kinetics consistent with this fluid acting as a sacrificial antioxidant. (freethesaurus.com)
  • 2. Aqueous humor is a watery fluid while vitreous is a jelly-like substance. (steadyrun.com)
  • Aqueous humor is the fluid produced by the eye. (brightfocus.org)
  • These fluids are humors in name only, and are necessary to eye function: The aqueous humor is a clear fluid that brings nutrients to the lens area of your eye, so that you're not-you know-looking at blood all the time. (mentalfloss.com)
  • Aqueous humor is a clear, watery fluid, contained in two chambers behind the cornea, that helps to bring nutrients to the eye tissues. (visionaware.org)
  • The health of your eye depends upon a continuous process of production, flow, and drainage of this aqueous fluid. (visionaware.org)
  • The objective of this proposal is to develop a surrogate tumor biopsy for retinoblastoma using the aqueous humor, which is the clear fluid in a separate part of the eye from where the tumor forms. (grantome.com)
  • The aqueous humor is a clear, watery fluid located behind the cornea. (verywellhealth.com)
  • Ding W, Ni W, Chen H, Yuan J, Huang X, Zhang Z, Wang Y, Yu Y, Yao K. Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. (medsci.org)
  • Furthermore we could find noticeable correlations between clinical characteristics and immune mediator concentrations in aqueous humor. (fu-berlin.de)
  • Distinguish, differentiate, compare and explain what is the main difference between aqueous and vitreous humor. (steadyrun.com)
  • 1. Aqueous humor occurs in aqueous chamber whereas vitreous humor occurs in vitreous chamber. (steadyrun.com)
  • The vitreous humor (or vitreous body) is the gelatinous goop that fills the inside of your eyeball. (mentalfloss.com)
  • The vitreous humor, which lies against the retina, makes up a large part of the eye. (verywellhealth.com)
  • As we age, the vitreous humor becomes less firm. (verywellhealth.com)
  • If the force of the pulling becomes strong enough, the vitreous humor may actually separate from the retina. (verywellhealth.com)
  • The effect of SLT on the aqueous humor dynamics is currently unknown. (clinicaltrials.gov)
  • This study will determine the changes in aqueous humor dynamics produced by SLT that lead to its IOP lowering effect. (clinicaltrials.gov)
  • It presents a timely update to current knowledge of the molecular transport mechanisms which underlie aqueous humor dynamics. (textbookx.com)
  • Effects of exogenous prostaglandins on aqueous humor dynamics and blood-aqueous barrier function. (semanticscholar.org)
  • Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension. (pubfacts.com)
  • This study evaluates aqueous humor dynamics in rhesus monkeys from the University of Florida inbred colony with ocular normotension and naturally occurring ocular hypertension. (pubfacts.com)
  • The individual parameters of aqueous humor dynamics may influence each other to maintain intraocular pressure (IOP) homeostasis. (nebraska.edu)
  • This study investigates the correlation between parameters of aqueous humor dynamics and the influence of CCT in healthy volunteers and compares it with the correlations seen in patients with ocular hypertension. (nebraska.edu)
  • Aqueous humor dynamics (aqueous flow, outflow facility, and uveoscleral outflow), IOP, and pachymetry data from 94 healthy ocular normotensive (ONT) volunteers and 63 ocular hypertensive (OHT) patients was analyzed retrospectively. (nebraska.edu)
  • Linear correlations between individual aqueous humor dynamics parameters and pachymetry were evaluated using scatter plots and the Spearman correlation coefficient where appropriate. (nebraska.edu)
  • The interplay between parameters of aqueous humor dynamics suggests possible autoregulatory mechanisms in the eye. (nebraska.edu)
  • These findings suggest that aqueous humor can serve as a surrogate tumor biopsy for analyses of tumor-derived DNA in retinoblastoma eyes. (aao.org)
  • Use of the aqueous humor as a surrogate tumor biopsy holds tremendous potential, from directly impacting the way we manage retinoblastoma patients, to ultimately allowing for the development of personalized medicine for this blinding childhood cancer. (grantome.com)
  • MIGS offer a small wound, safe, and fast surgical approach to enhance aqueous humor outflow (AHO) drainage. (omicsonline.org)
  • Pilocarpine and latanoprost, known to enhance aqueous humor outflow in humans, accelerated the decay of fluorescence. (scienceexchange.com)
  • Lidocaine concentration was measured in aqueous humor samples taken before surgery. (diva-portal.org)
  • RESULTS: With 3 drops, aqueous lidocaine concentration was 1.4 micrograms/mL +/- 0.5 (SD) and with 6 drops, 4.3 +/- 1.5 micrograms/mL (P = .0015). (diva-portal.org)
  • The purpose of this study is to obtain and assay human aqueous samples following pre-operative dosing with 0.1% Brimonidine Purite™ (pH 7.8) or with 0.15% Brimonidine Purite® (pH 7.2) from patients undergoing routine cataract surgery in order to evaluate the aqueous concentration of the two formulations. (clinicaltrials.gov)
  • All aqueous humor (AqH) samples were tested for total protein concentration, ability to suppress in vitro T-cell activation, and total TGF-β 2 content. (egms.de)
  • 0.3% gatifloxacin ophthalmic gel application produced highest aqueous humor drug concentration, maintained the longest time, had the best penetration and bioavailability. (medsci.org)
  • Cell number and protein concentration in the aqueous humor begin to increase 6 hours after the endotoxin injection and reach a peak at 24 hours before gradually decreasing. (freethesaurus.com)
  • The concentration of TF in aqueous humor (AH) was compared with the grade of DR. The concentration of TF in AH was also compared with duration of diabetes, renal function, and blood glucose control. (elsevier.com)
  • To investigate the relationship between the concentration of aqueous humor cytokines and the severity of diabetic retinopathy . (bvsalud.org)
  • Quantitative analysis of the expressed cytokines in the aqueous humor was performed using FlowCytomix FC 500 Pro 3.0 Software (Bender MedSystems GmbH, Vienna, Austria). (healio.com)
  • Levels of various inflammation-related cytokines in the aqueous humor of using multiplex immunoassay. (arvojournals.org)
  • Aqueous humor cytokine profiling in patients with wet AMD. (nih.gov)
  • The research was to evaluate cytokine profile in aqueous humor of congenital cataract with PCD to search the pathogeny of PCD. (arvojournals.org)
  • Conclusion: Cytokine expression pattern in the aqueous humor, in contrast to that in serum, may reflect intraocular immune reactions during active inflammation in patients with AAU. (eurekaselect.com)
  • To provide clarity regarding the treatment and prognosis of idiopathic macular holes, specifically regarding the levels of cytokines in affected patients, this study examined and analyzed multiple cytokine levels in aqueous humor from patients with idiopathic macular holes. (researchsquare.com)
  • There were significant differences in aqueous humor cytokine levels between patients with idiopathic macular holes and patients in the cataract control group. (researchsquare.com)
  • Patients with idiopathic macular holes showed significant variation in aqueous humor immune response after the onset of hole formation, including the recruitment of immune cells and regulation of cytokine expression. (researchsquare.com)
  • Our findings also suggest that it is not appropriate to use patients with macular holes as the control group in studies of aqueous humor cytokine levels in ophthalmic diseases. (researchsquare.com)
  • Since the aqueous humor passes directly into the venous system, the normal drainage process for aqueous humor is restored. (google.com)
  • The aqueous humor continues its drainage path into collector channels and finally into aqueous veins to enter the venous system. (google.com)
  • It is called "open-angle" because the angle between the iris and the cornea is open, allowing drainage of the aqueous humor. (encyclopedia.com)
  • Posterior chamber is an important structure involved in production and circulation of aqueous humor. (wikipedia.org)
  • Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. (nih.gov)
  • To investigate the penetration of 0.3% gatifloxacin ophthalmic gel, 0.3% gatifloxacin ophthalmic solution and 0.5% levofloxacin ophthalmic solution into aqueous humor after topical application. (medsci.org)
  • Conclusion: Our new findings indicate that in PBK the complement system is activated-via the classical pathway-in the aqueous humor. (elsevier.com)
  • Assays of immune privilege markers in AqH reveal that mean TGF-β 2 content is abnormally low in patients coming to PK due to the high risk cases and that PK surgery results in a sustained loss of integrity of the blood-aqueous barrier. (egms.de)
  • Methods 40 consecutive cases of TRC with a positive aqueous humour (AH) tap for toxoplasmosis were retrospectively included. (ovid.com)
  • The aqueous humour resembles blood plasma in composition but contains less protein and glucose and more lactic acid and ascorbic acid . (britannica.com)
  • When the aqueous humour does not adequately drain from the eye, intraocular pressure can rise and loss of vision can result. (britannica.com)
  • During the night, intraocular pressure may not decrease despite the slower production of aqueous humour. (wikipedia.org)
  • T. gondii-specific IgM and IgG were measured in serum and aqueous humor from the cats at each sample data. (unboundmedicine.com)
  • Many studies reported that serum and aqueous VEGF increased in cases of NVG and proliferative diabetic retinopathy (PDR). (scirp.org)
  • The present study was performed to correlate between the level of VEGF in both serum and aqueous humor in cases with NVG without studying any other contributing factors in the body, in a trial for early laboratory detection of ocular new vessels formation which may be beneficial for early treatment and prevention of blindness. (scirp.org)
  • This study finds that aqueous humor from retinoblastoma eyes contains tumor-derived DNA that can be analyzed as an alternative to tissue biopsy. (aao.org)
  • Aqueous humor biopsy may be an improvement over existing methods, as it could require less advanced technical skills and carry a lower risk of causing ocular or systemic comorbidity. (aao.org)
  • 3 Since then, our lab's focus has been using the aqueous humor as an organ-specific liquid biopsy for RB. (nature.com)
  • From our initial publication, we quickly began to investigate potential prognostic biomarkers via the aqueous humor liquid biopsy. (nature.com)
  • Development of a surrogate liquid biopsy from the aqueous humor in retinoblastoma eyes. (grantome.com)
  • The lens influences aqueous humor levels of transforming growth factor-beta 2. (biomedsearch.com)
  • Selenium concentrations in serum, lens and aqueous humor of patients with senile cataract. (freethesaurus.com)
  • The region of the eye between the cornea and the lens that contains aqueous humor. (brightfocus.org)
  • Part of the eye, above the lens, that produces the aqueous humor. (brightfocus.org)
  • The iris, cornea, and lens are bathed in a liquid called the aqueous humor, which is somewhat similar to plasma. (encyclopedia.com)
  • The hypermature cataractous lens or,the intraocular lens (IOL) implanted after cataract surgery may obstruct the aqueous flow through the pupil. (wikipedia.org)
  • Previous studies have focused upon investigating changes in the sclera, retina, and choroid in high myopia, but few studies have been directed toward assessing the aqueous humor (AH) in these patients. (molvis.org)
  • We describe a patient with serologically proven visceral toxocariasis who had a granulomatous lesion in the iris, small rod-like lesions in the retina, and in whom Toxocara -specific antibodies were also demonstrated in the aqueous humor. (ajtmh.org)
  • Methods: Aqueous humor samples were collected during keratoplasty of 12 PBK patients, as well as during phacoemulsification surgery of 18 control patients. (elsevier.com)
  • To determine if factors present in the aqueous humor (AH) protect the corneal endothelium from apoptosis. (elsevier.com)
  • 11:00 AM the day of the study, 16.0 ± 1.6 versus 13.3 ± 2.9 mmHg, p = 0.05) and lower aqueous flow (2.12 ± 0.40 versus 4.54 ± 1.11 μl/min, p = 0.0001), outflow facility (0.17 ± 0.10 versus 0.33 ± 0.07 μl/min/mmHg, p = 0.01) and uveoscleral outflow (p (pubfacts.com)
  • Thicker corneas may be associated with lower aqueous production and lower uveoscleral outflow. (nebraska.edu)
  • abstract = "Introduction: Cornea is the outermost part of the eye supplied mostly by aqueous humor (AH). (nsu.ru)
  • Intraocular pressure in the sitting position changes minimally during sleep, although aqueous humor flow decreases by 50% or more at night. (arvojournals.org)
  • Aqueous humor flow rate, IOP in the sitting position, outflow facility, and EVP were measured in each eye during the middiurnal period (2:00-4:00 PM). Uveoscleral flow was calculated from the other variables by using the modified Goldmann equation. (arvojournals.org)
  • The nocturnal decrease in aqueous humor flow rate in older, healthy subjects is compensated by a small decrease in outflow facility and a large decrease in uveoscleral outflow to maintain a stable IOP. (arvojournals.org)
  • 1 - 5 This behavior is the opposite of that of aqueous humor flow, which decreases by as much as 50% during sleep. (arvojournals.org)
  • 6 - 8 Because IOP is directly related to aqueous humor flow, the dramatic decrease in flow rate must be compensated by a decrease in outflow facility, an increase in episcleral venous pressure, or a diminished nonconventional outflow during sleep. (arvojournals.org)
  • In an earlier study, outflow facility decreased somewhat at night, but the decrease was not enough to compensate entirely for the typical decrease in aqueous humor flow rate 9 and we were not able to detect this pattern in young, healthy subjects. (arvojournals.org)
  • Uveoscleral flow cannot be measured directly but must be calculated from IOP, aqueous humor flow, outflow facility, and EVP measured at approximately the same time. (arvojournals.org)
  • A system was developed to measure the instantaneous perfusate flow rate through the aqueous humor outflow network of a human eye, while under constant pressure. (tdl.org)
  • The system monitors real-time weight changes of a perfusate reservoir associated with perfusate flow through the aqueous humor outflow network. (tdl.org)
  • Assessments included central cornea thickness by ultrasound pachymetry, IOP by tonometry, aqueous flow and outflow facility by fluorophotometry, and uveoscleral outflow by mathematical calculation. (pubfacts.com)
  • These animals also have slower aqueous flow than the ONT animals which does not contribute to the higher IOP. (pubfacts.com)
  • 0.001) positive correlation was found between aqueous flow and uveoscleral outflow (R 2 = 0.15).Conclusions. (nebraska.edu)
  • The flow field of aqueous humor correlates to the stiffness of iris pigment epithelium (IPE) which acts as a wall of posterior chamber. (hindawi.com)
  • A recent publication focuses on the flow of aqueous humor in the posterior chamber [ 9 ]. (hindawi.com)
  • Compared with the control group, the aqueous humor in wet AMD patients showed a significantly higher expression of CXCL10 (p=0.004), CCL14 (p=0.002), CXCL16 (p=0.013), CXCL7 (p=0.033), and CCL22 (p=0.037), while growth-related oncogene (GRO) was significantly decreased in the wet AMD patients (p=0.001). (nih.gov)
  • Surprisingly, aqueous humor from aphakic rabbit eyes contained significantly higher levels of TGF-beta 2 than their contralateral phakic controls. (biomedsearch.com)
  • Furthermore, aqueous humor from canine eyes with cataracts also contained significantly higher levels of TGF-beta 2 than normal eyes. (biomedsearch.com)
  • When the control group was compared with the PDR and NPDR groups, aqueous levels of IL-6 were significantly higher in PDR patients than in those of both the control and NPDR groups (p = 0.016 and p = 0.003, respectively). (bvsalud.org)
  • The aqueous levels of VEGF were significantly higher in the eyes of PDR patients than in those of the control group (p = 0.003). (bvsalud.org)
  • Investigators obtained aqueous humor samples from 3 eyes with retinoblastoma, including 2 after primary enucleation. (aao.org)
  • therefore, this study aimed to identify cfDNA in the aqueous humor (AH) of retinoblastoma eyes and correlate somatic chromosomal copy-number alterations (SCNA) with clinical outcomes, specifically eye salvage. (aacrjournals.org)
  • We sample the aqueous humor found in the front of the eye to study genomic alterations in retinoblastoma. (nature.com)
  • Aim 1 is to define highly recurrent chromosomal changes in the aqueous, such as 2p gain/MYCN amplification, that are known to occur in retinoblastoma tumors. (grantome.com)
  • The objective of this proposal is to evaluate tumor-specific genetic markers in the aqueous humor, which is safe to extract even in advanced retinoblastoma eyes. (grantome.com)
  • Aqueous samples were collected at different time points after the last drop. (medsci.org)
  • A simple and sensitive ultra performance liquid chromatographic (UPLC) method with ultraviolet (UV) detection was developed and validated for the quantification of dorzolamide (DZA) in rabbit aqueous humor. (eurekaselect.com)
  • This phenomenon provides the major indication that aqueous humor secretion is regulated. (textbookx.com)
  • below, but some systems to this download The Eye\'s Aqueous Humor: From Secretion to were loved invoicing to book readers, or because the first-instance sent made from leading. (sociologiaonline.org)
  • Such a physical book The Eye\'s Aqueous Humor: From Secretion may see the power or the direction Frozen which would share a group since these appear improper genes. (lgne.org)
  • To investigate the chemokine expression profiles in the aqueous humor of wet age-related macular degeneration (wet AMD) patients and to correlate their levels with clinical findings. (nih.gov)
  • The book emphasizes the phenomenon of the diurnal rhythm of aqueous humor formation, from both the clinical and molecular points of view. (textbookx.com)
  • Growth factors in the aqueous humor and their clinical significance. (semanticscholar.org)
  • article{Tripathi1994GrowthFI, title={Growth factors in the aqueous humor and their clinical significance. (semanticscholar.org)
  • more precisely, the aqueous harbors tumor-derived genetic material which can be assayed and correlated with clinical outcomes. (grantome.com)
  • Finally, Aim 3 will evaluate RNA expression profiles to define subgroups in the aqueous, and correlate these with clinical outcomes such as tumor recurrence. (grantome.com)
  • The authors adopted next-generation sequencing (NGS) techniques to further characterize the miRNA profile in single samples of 60 to 80 μL human aqueous humor. (nih.gov)
  • The aqueous humor miRNA profile shows some overlap with published NGS-derived inventories of circulating miRNAs in blood plasma with high prevalence of human miR-451a, -21, and -16. (nih.gov)
  • Notrox has vast experience in handling human aqueous humor sample analysis by liquid chromatography (LC)and mass spectrometry (MS). The company has conducted bioequivalance studies in post cataract surgery for generic products. (pharmaceutical-technology.com)
  • The purpose of this study is to determine whether lipids derived from omega-3 and omega-6 polyunsaturated fatty acids (PUFA) are present in human aqueous humor. (arvojournals.org)
  • We demonstrate the presence of omega-3 and omega-6 PUFAs in human aqueous humor. (arvojournals.org)
  • The identification of PUFAs in human aqueous humor helps build a foundation for the development of novel therapeutic agents and diagnostic tests. (arvojournals.org)
  • However, the utility of topical caspofungin in fungal keratitis remains unknown, partly due to limited data on its penetration into human aqueous humor after topical administration. (asm.org)
  • This study aimed to investigate the ocular penetration of 0.5% caspofungin eye drops into human aqueous humor. (asm.org)
  • The organizing hypothesis of this project is that in the human eye monocytes interact with SCE cells in a paracrine manner, thus forming a cellular module that regulates the outflow of aqueous humor. (grantome.com)
  • Purpose: To determine the differential profiles of sphingomyelin, sphingoid base, sphingoid base-1-phosphate and ceramide lipid species and their quantitative differences between control and glaucomatous aqueous humor (AQH) derived from human donors. (elsevier.com)
  • Hypoxanthine and xanthine levels in human aqueous humor from cataractous eyes. (uniroma1.it)
  • Interestingly and for the first time, we could observe that recurrent OT is characterized by reduced immune mediator concentrations of IL-7 (p=0.031) and IL-9 (p=0.046) in human aqueous humor. (fu-berlin.de)
  • OHT may differ from ONT subjects in their inability to increase the uveoscleral outflow with increases in aqueous inflow. (nebraska.edu)
  • Evaluation of aqueous humor demonstrated tumor-derived, cell-free DNA and regions of chromosomal gains and losses, representing changes in the tumor. (aao.org)
  • Our preliminary data from evaluation of the aqueous revealed that tumor-derived cell-free DNA is present and whole genome sequencing demonstrates a profile of chromosomal gains and losses that corroborate changes in the tumor. (grantome.com)
  • Higher preoperative levels of TGFβ2, IL-6, VEGF in aqueous humor were associated with posterior capsule defect, which indicated the inflammation state in congenital cataract with posterior capsule defect. (arvojournals.org)
  • Among cytokines of all aqueous samples, preoperative IOP was positively associated with expression quantity of sVEGFR-1 (r = 0.647, p = 0.02) and VEGF-A (r = 0.602, p = 0.04) and negatively associated with plasminogen activator inhibitor 1 expression (r = -0.593, p = 0.04). (researchsquare.com)
  • Serum VEGF was estimated in all groups, also aqueous humor VEGF was estimated in group A and B only. (scirp.org)
  • Also aqueous VEGF level in group B was increased significantly from control group A (P (scirp.org)
  • In group B, the study reported a positive correlation between serum VEGF (S-VEGF) and aqueous humor VEGF (A-VEGF) levels (r = 0.638) with a high significant result (P (scirp.org)
  • Conclusions: VEGF is considered a good marker for the NVG either in serum or aqueous humor, laser treatment and the use of anti-VEGF are crucial treatment for such cases, and also glycemic control is a must for regulation of the vascular process in diabetic patients for prevention of such ocular neovascularization. (scirp.org)
  • Measuring of VEGF either in the serum or aqueous can be a good method in monitoring the neovascular processes in cases with ischemic retinal conditions especially diabetic ones. (scirp.org)
  • Aqueous levels of IL-6 and VEGF were higher in the eyes of PDR patients than in those of healthy controls. (bvsalud.org)