AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHumanitiesPublication Characteristics
Aqueous HumorWit and Humor as TopicTrabecular MeshworkCiliary BodyFluorophotometryIntraocular PressureIrisAnterior ChamberVitreous BodyUveitisBlood-Aqueous BarrierUveitis, AnteriorAnterior Eye SegmentEye ProteinsAdministration, TopicalCataractRabbitsTimololScleraGlaucomaExfoliation SyndromeUveaEyeToxoplasmosis, OcularGlaucoma, Open-AngleCorneaOphthalmic SolutionsTonometry, OcularIridocyclitisCataract ExtractionPupilTransforming Growth Factor beta2Lens, CrystallineEndothelium, CornealGlaucoma, NeovascularEye InfectionsEye DiseasesTropicamideCarbonic Anhydrase InhibitorsProstaglandins F, SyntheticLevobunololFluoresceinHumorOcular HypotensionMacaca fascicularisMethazolamideAscorbic AcidEndophthalmitisLaughterTrabeculectomyEye NeoplasmsInjectionsMoxisylyteHeptanolEnzyme-Linked Immunosorbent AssayEye Infections, ViralOcular HypertensionPilocarpineFluoresceinsRetinal Necrosis Syndrome, AcuteVenous PressureHydrophthalmosGanglionectomyCorneal TransplantationMiotics
Aqueous Humor
The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)
Wit and Humor as Topic
The faculty of expressing the amusing, clever, or comical or the keen perception and cleverly apt expression of connections between ideas that awaken amusement and pleasure. (From Random House Unabridged Dictionary, 2d ed)
Trabecular Meshwork
A porelike structure surrounding the entire circumference of the anterior chamber through which aqueous humor circulates to the canal of Schlemm.
Ciliary Body
A ring of tissue extending from the scleral spur to the ora serrata of the RETINA. It consists of the uveal portion and the epithelial portion. The ciliary muscle is in the uveal portion and the ciliary processes are in the epithelial portion.
Fluorophotometry
Measurement of light given off by fluorescein in order to assess the integrity of various ocular barriers. The method is used to investigate the blood-aqueous barrier, blood-retinal barrier, aqueous flow measurements, corneal endothelial permeability, and tear flow dynamics.
Intraocular Pressure
The pressure of the fluids in the eye.
Iris
The most anterior portion of the uveal layer, separating the anterior chamber from the posterior. It consists of two layers - the stroma and the pigmented epithelium. Color of the iris depends on the amount of melanin in the stroma on reflection from the pigmented epithelium.
Anterior Chamber
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
Vitreous Body
The transparent, semigelatinous substance that fills the cavity behind the CRYSTALLINE LENS of the EYE and in front of the RETINA. It is contained in a thin hyaloid membrane and forms about four fifths of the optic globe.
Uveitis
Inflammation of part or all of the uvea, the middle (vascular) tunic of the eye, and commonly involving the other tunics (sclera and cornea, and the retina). (Dorland, 27th ed)
Blood-Aqueous Barrier
The selectively permeable barrier, in the EYE, formed by the nonpigmented layer of the EPITHELIUM of the CILIARY BODY, and the ENDOTHELIUM of the BLOOD VESSELS of the IRIS. TIGHT JUNCTIONS joining adjacent cells keep the barrier between cells continuous.
Uveitis, Anterior
Inflammation of the anterior uvea comprising the iris, angle structures, and the ciliary body. Manifestations of this disorder include ciliary injection, exudation into the anterior chamber, iris changes, and adhesions between the iris and lens (posterior synechiae). Intraocular pressure may be increased or reduced.
Anterior Eye Segment
The front third of the eyeball that includes the structures between the front surface of the cornea and the front of the VITREOUS BODY.
Eye Proteins
Administration, Topical
The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.
Cataract
Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
Rabbits
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Timolol
A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
Sclera
The white, opaque, fibrous, outer tunic of the eyeball, covering it entirely excepting the segment covered anteriorly by the cornea. It is essentially avascular but contains apertures for vessels, lymphatics, and nerves. It receives the tendons of insertion of the extraocular muscles and at the corneoscleral junction contains the canal of Schlemm. (From Cline et al., Dictionary of Visual Science, 4th ed)
Glaucoma
An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)
Exfoliation Syndrome
The deposition of flaky, translucent fibrillar material most conspicuous on the anterior lens capsule and pupillary margin but also in both surfaces of the iris, the zonules, trabecular meshwork, ciliary body, corneal endothelium, and orbital blood vessels. It sometimes forms a membrane on the anterior iris surface. Exfoliation refers to the shedding of pigment by the iris. (Newell, Ophthalmology, 7th ed, p380)
Uvea
The pigmented vascular coat of the eyeball, consisting of the CHOROID; CILIARY BODY; and IRIS, which are continuous with each other. (Cline et al., Dictionary of Visual Science, 4th ed)
Eye
The organ of sight constituting a pair of globular organs made up of a three-layered roughly spherical structure specialized for receiving and responding to light.
Toxoplasmosis, Ocular
Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.
Glaucoma, Open-Angle
Glaucoma in which the angle of the anterior chamber is open and the trabecular meshwork does not encroach on the base of the iris.
Cornea
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Ophthalmic Solutions
Sterile solutions that are intended for instillation into the eye. It does not include solutions for cleaning eyeglasses or CONTACT LENS SOLUTIONS.
Tonometry, Ocular
Measurement of ocular tension (INTRAOCULAR PRESSURE) with a tonometer. (Cline, et al., Dictionary of Visual Science, 4th ed)
Iridocyclitis
Acute or chronic inflammation of the iris and ciliary body characterized by exudates into the anterior chamber, discoloration of the iris, and constricted, sluggish pupil. Symptoms include radiating pain, photophobia, lacrimation, and interference with vision.
Cataract Extraction
The removal of a cataractous CRYSTALLINE LENS from the eye.
Pupil
The aperture in the iris through which light passes.
Transforming Growth Factor beta2
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
Lens, Crystalline
A transparent, biconvex structure of the EYE, enclosed in a capsule and situated behind the IRIS and in front of the vitreous humor (VITREOUS BODY). It is slightly overlapped at its margin by the ciliary processes. Adaptation by the CILIARY BODY is crucial for OCULAR ACCOMMODATION.
Endothelium, Corneal
Single layer of large flattened cells covering the surface of the cornea.
Glaucoma, Neovascular
A form of secondary glaucoma which develops as a consequence of another ocular disease and is attributed to the forming of new vessels in the angle of the anterior chamber.
Eye Infections
Infection, moderate to severe, caused by bacteria, fungi, or viruses, which occurs either on the external surface of the eye or intraocularly with probable inflammation, visual impairment, or blindness.
Eye Diseases
Diseases affecting the eye.
Tropicamide
One of the MUSCARINIC ANTAGONISTS with pharmacologic action similar to ATROPINE and used mainly as an ophthalmic parasympatholytic or mydriatic.
Carbonic Anhydrase Inhibitors
A class of compounds that reduces the secretion of H+ ions by the proximal kidney tubule through inhibition of CARBONIC ANHYDRASES.
Prostaglandins F, Synthetic
Analogs or derivatives of prostaglandins F that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGF.
Levobunolol
The L-Isomer of bunolol.
Fluorescein
A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.
Humor
Ocular Hypotension
Abnormally low intraocular pressure often related to chronic inflammation (uveitis).
Macaca fascicularis
A species of the genus MACACA which typically lives near the coast in tidal creeks and mangrove swamps primarily on the islands of the Malay peninsula.
Methazolamide
A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.
Ascorbic Acid
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
Endophthalmitis
Suppurative inflammation of the tissues of the internal structures of the eye frequently associated with an infection.
Laughter
An involuntary expression of merriment and pleasure; it includes the patterned motor responses as well as the inarticulate vocalization.
Trabeculectomy
Any surgical procedure for treatment of glaucoma by means of puncture or reshaping of the trabecular meshwork. It includes goniotomy, trabeculectomy, and laser perforation.
Eye Neoplasms
Tumors or cancer of the EYE.
Injections
Introduction of substances into the body using a needle and syringe.
Moxisylyte
An alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)
Heptanol
A colorless liquid with a fragrant odor. It is used as an intermediate, solvent and in cosmetics.
Enzyme-Linked Immunosorbent Assay
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Eye Infections, Viral
Infections of the eye caused by minute intracellular agents. These infections may lead to severe inflammation in various parts of the eye - conjunctiva, iris, eyelids, etc. Several viruses have been identified as the causative agents. Among these are Herpesvirus, Adenovirus, Poxvirus, and Myxovirus.
Ocular Hypertension
A condition in which the intraocular pressure is elevated above normal and which may lead to glaucoma.
Pilocarpine
A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
Fluoresceins
A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
Retinal Necrosis Syndrome, Acute
Mild to fulminant necrotizing vaso-occlusive retinitis associated with a high incidence of retinal detachment and poor vision outcome.
Venous Pressure
The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE.
Hydrophthalmos
Congenital open-angle glaucoma that results from dysgenesis of the angle structures accompanied by increased intraocular pressure and enlargement of the eye. Treatment is both medical and surgical.
Ganglionectomy
Removal of an autonomic or sensory ganglion by any means.
Corneal Transplantation
Partial or total replacement of the CORNEA from one human or animal to another.
Miotics
Agents causing contraction of the pupil of the eye. Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here.

Estimation of corneal endothelial pump function in long-term contact lens wearers. (1/1321)

PURPOSE: To study the effects of long-term contact lens wear on morphologic and physiologic properties of corneal endothelial cells. METHODS: The endothelial permeability to fluorescein and the rate of corneal deswelling from hypoxia-induced edema were measured in 20 long-term (mean, 17+/-9 years; range, 5-33 years) contact lens wearers and 20 age-matched control subjects. From these data, the relative endothelial pump rate in each subject was estimated, based on the pump-leak hypothesis of corneal hydration control. Corneal autofluorescence and the aqueous humor flow rate were determined by fluorescein fluorophotometry. Images of corneal endothelial cells were recorded by using specular microscopy, and morphologic indices (cell density, coefficient of variation of cell area, percentage of hexagonal cells, and skewness) were determined. RESULTS: No statistically significant differences were found between the contact lens and control groups in endothelial permeability, corneal deswelling, relative endothelial pump rate ([mean +/- SD] 1.07+/-0.33 relative pump units versus 1.01+/-0.25 relative pump units; contact lens versus control; P = 0.57), and endothelial cell density. Contact lens wearers had a significantly higher aqueous humor flow rate (3.57+/-1.03 microl/min versus 2.77+/-0.51 microl/min; P = 0.005), coefficient of variation of cell area (0.35+/-0.09 versus 0.28+/-0.04; P = 0.006), and corneal autofluorescence (3.1+/-0.6 ng/ml versus 2.3+/-0.3 ng/ml fluorescein equivalents; P < 0.001) than did non-contact lens wearers. CONCLUSIONS: Despite the known effects of long-term contact lens wear on corneal endothelial morphometry, no effect on endothelial function was found.  (+info)

Latrunculin-A increases outflow facility in the monkey. (2/1321)

PURPOSE: To determine the effect of Latrunculin (LAT)-A, a macrolide that binds to G-actin, which leads to the disassembly of actin filaments, on shape, junctions, and the cytoskeleton of cultured bovine aortic endothelial cells (BAECs) and on outflow facility in living monkeys. METHODS: Latrunculin-A dose-time-response relationships in BAECs were determined by immunofluorescence and phase contrast light microscopy, facility by two-level constant pressure anterior chamber perfusion. RESULTS: In BAECs, LAT-A caused dose- and incubation time- dependent destruction of actin bundles, cell separation, and cell loss. Cell-cell adhesions were more sensitive than focal contacts. Recovery was also dose- and time-dependent. In monkeys, exchange intracameral infusion and topical application of LAT-A induced dose- and time-dependent several-fold facility increases. The facility increase was completely reversed within several hours after drug removal. However, for at least 24 hours after a single topical LAT-A dose, perfusion with drug-free solution caused an accelerated increase in facility beyond that attributed to normal resistance washout. CONCLUSIONS: Pharmacological disorganization of the actin cytoskeleton in the trabecular meshwork by specific actin inhibitors like LAT-A may be a useful antiglaucoma strategy.  (+info)

Effect of staurosporine on outflow facility in monkeys. (3/1321)

PURPOSE: To determine the effect of the serine-threonine kinase inhibitor staurosporine on outflow facility in living monkeys. METHODS: Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber bilaterally before and after intracameral infusion of staurosporine or vehicle in opposite eyes. RESULTS: Intracameral staurosporine dose-dependently doubled outflow facility, with 0.1 microM, 1 microM, and 10 microM being subthreshold, effective, and maximal doses, respectively. At 50 microM, intracameral staurosporine was less effective than 10 microM on facility and induced corneal toxicity. CONCLUSIONS: The broad-spectrum protein kinase inhibitor staurosporine increases outflow facility in living monkeys, perhaps by affecting the trabecular meshwork cytoskeleton.  (+info)

Cytomegalovirus (CMV) retinitis activity is accurately reflected by the presence and level of CMV DNA in aqueous humor and vitreous. (4/1321)

To evaluate the potential of ocular and systemic specimens to provide markers of active cytomegalovirus (CMV) retinitis, we examined the relationship between virologic and clinical aspects of CMV infections in AIDS patients with CMV retinitis. CMV polymerase chain reaction (PCR) analysis of 74 aqueous humor and vitreous specimens indicated that ocular specimens can provide accurate markers to differentiate active and inactive CMV retinitis (aqueous or vitreous PCR, P<.001). Moreover, these markers were superior to extraocular measures, including plasma PCR (P=.08) and blood and urine CMV cultures (P=.05). A direct correlation was identified between the quantity of CMV DNA in aqueous humor or vitreous specimens and the corresponding surface area of active CMV retinitis (r2=.69 and.44, respectively). Thus, qualitative and quantitative PCR-based analyses of aqueous humor can provide valuable markers of CMV retinitis activity. Such assays could provide rapid and reliable tools to assist in management of patients with CMV retinitis in whom the view of the retina is obscured.  (+info)

High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice. (5/1321)

In order to investigate whether the p53 gene product plays a role in normal eye development, age matched p53-deficient mice and wild-type controls were sacrificed from day 2 to day 21 after birth. Eyes were paraffin-embedded and sectioned. Serial sections were taken at the level of the tunica vasculosa lentis and the hyaloid artery. The terminal dUTP nick-end labelling technique (TUNEL) was used to detect the number of cells displaying DNA fragmentation within these structures. Eyes were also prepared for scanning electron microscopy and resin embedded for semi-thin sections. Adult wild-type mice and p53-deficient mice were examined ophthalmoscopically in vivo. Ophthalmoscopical examination of mice completely deficient in p53 revealed them to be normal except for the persistence of the hyaloid vasculature, a structure that normally regresses during eye development. In adult animals there was also a high frequency of cataracts. Using morphological assessment and TUNEL we could show that in normal mice, regression of the primary vitreous, which includes the hyaloid artery, the vasa hyaloidea propria as well as the tunica vasculosa lentis, occurs via apoptotic cell death within 5 - 6 weeks after birth. The number of TUNEL-positive cells within these structures was significantly reduced in the p53-deficient mice in which parts of the hyaloid vasculature persisted and developed into a fibro-vascular retrolental plaque analogous to persistent hyperplastic primary vitreous (PHPV) described in humans. As in humans, PHPV in mice resulted in the development of cataracts. We have identified a role for p53-dependent apoptosis in the regression of the hyaloid vasculature and tunica vasculosa lentis. Our results provide further evidence for the importance of p53 in normal development and provide the first detailed evidence of its role in postnatal development in remodelling the developing eye.  (+info)

Electrical parameters of the isolated cornea of the dogfish, Squalus acanthias. (6/1321)

The electrical potential difference and electrical resistance of the nonswelling cornea of the dogfish, Squalus acanthias, were examined. It was found that routine procedures used in the procurement of fish invariably produce damage to the corneal epithelium which affects electrical measurements and possibly composition of the aqueous humor. We found no electrical evidence of ionic pumps in the corneal epithelium of this elasmobranch. The electrical resistance of corneas with apparently well-preserved epithelium was 300omega-cm.2 (compared to 30omega-cm.2 in corneas with damaged epithelium).  (+info)

Enthacrynic and acid effects on inner wall pores in living monkeys. (7/1321)

PURPOSE: The influence of the inner wall of Schlemm's canal on aqueous outflow facility remains poorly understood. We examined the relationship between inner wall pore characteristics and outflow facility in living primate eyes in which facility had been pharmacologically increased by ethacrynic acid (ECA) infusion and in contralateral control eyes. METHODS: Outflow facility (two-level constant pressure perfusion) was measured in eight pairs of living monkey eyes before and after administration of a bolus dose of either 0.125 mM ECA or vehicle. After exsanguination, eyes were fixed in situ under constant-pressure conditions (mean fixation pressure approximately 19 mm Hg). The density and diameter of inner wall pores and the number and area of platelet aggregates on the inner wall of Schlemm's canal were measured by scanning electron microscopy. RESULTS: In ECA-treated eyes, outflow facility increased 63% (P < 0.0001), intracellular pore density decreased 46% (P = 0.0094), intracellular pore size increased 27% (P = 0.049), platelet aggregate density increased 158% (P < 0.0001), and area covered by platelets increased 210% (P = 0.012) relative to contralateral controls. Although the average density and size of intercellular pores were essentially unaffected by ECA, an increased density of large (> or = 1.90 microm) intercellular pores was seen in ECA-treated eyes. The density of intracellular pores increased with the duration of fixative perfusion. Other than a weak negative correlation between outflow facility and intracellular pore density in ECA-treated eyes (P = 0.052), facility was not correlated with inner wall pore features. CONCLUSIONS: Our data are most consistent with a scenario in which ECA promotes formation of large intercellular pores in the inner wall of Schlemm's canal, which are then masked by platelet aggregates. Masking of intercellular pores, combined with fixation-induced alteration of inner wall pore density, greatly complicates attempts to relate facility to inner wall structure and suggests that in vivo pore density is smaller than in fixed tissue. Additionally, facility-influencing effects of ECA on the juxtacanalicular tissue cannot be excluded.  (+info)

Effect of aqueous humor on apoptosis of inflammatory cell types. (8/1321)

PURPOSE: To determine whether aqueous humor promotes cell death in cells involved in inflammatory responses. METHODS: Multiple immune cell types, most characteristically involved in inflammatory responses, were incubated for 24, 48, and 72 hours in the presence or absence of 50% aqueous humor. Promotion of cell death was assayed by staining for an early indicator of apoptosis. The percentage of cells undergoing apoptosis was measured by flow cytometry. To identify partially the apoptosis inducing factor, aqueous humor was pretreated with proteinase K to degrade protein. In other experiments, aqueous humor was fractionated by centrifugation on filters capable of separating molecules above and below 10 kDa or 30 kDa kilodaltons in size. RESULTS: Rabbit aqueous humor promoted apoptosis in a wide variety of immune cells, including lymphokine-activated natural killer cells, resting T cells, an activated T-cell line, RAW 264.7 and J774A0.1 monocyte-macrophage cell lines, and neutrophils. As previously shown, aqueous humor did not promote apoptosis of murine corneal endothelial cells. Apoptosis was also not induced in human corneal endothelium, mouse corneal epithelium, or iris/ciliary body cell lines. Instead, aqueous humor partially protected these ocular tissues from starvation-induced cell death. Pretreatment with proteinase K inhibited the apoptosis-inducing activity. Moreover, the apoptosis-inducing activity segregated with the aqueous humor fraction containing molecules less than than 10 kDa in size. CONCLUSIONS: These data show that aqueous humor contains a factor or factors that promote death of cells that participate in inflammatory processes. By contrast, ocular tissues, such as the corneal endothelium and iris/ciliary body, are impervious to aqueous humor-induced cell death. The aqueous humor- borne factor(s) may contribute to the immune privilege of the anterior chamber by purging potential inflammatory cells.  (+info)

Aqueous humour - WikipediaAqueous humour - Wikipedia
Aqueous humour is continually produced by the ciliary processes and this rate of production must be balanced by an equal rate of aqueous humour drainage. Small variations in the production or outflow of aqueous humour will have a large influence on the intraocular pressure. The drainage route for aqueous humour flow is first through the posterior chamber, then the narrow space between the posterior iris and the anterior lens (contributes to small resistance), through the pupil to enter the anterior chamber. From there, the aqueous humour exits the eye through the trabecular meshwork into Schlemms canal (a channel at the limbus, i.e., the joining point of the cornea and sclera, which encircles the cornea[5]) It flows through 25-30 collector canals into the episcleral veins. The greatest resistance to aqueous flow is provided by the trabecular meshwork (esp. the juxtacanalicular part), and this is where most of the aqueous outflow occurs. The internal wall of the canal is very delicate and allows ...
https://en.m.wikipedia.org/wiki/Aqueous_humor
Hypoxanthine and xanthine levels in human aqueous humor from cataractous eyes. | IRIS Uniroma1Hypoxanthine and xanthine levels in human aqueous humor from cataractous eyes. | IRIS Uniroma1
Purine nucleotide degradation products have been determined by HPLC in aqueous humor obtained during cataract surgery and from plasma of 22 patients (12 women). Uric acid, cytosine, guanosine monophosphate, uracyl, guanine, adenosine, adenosine monophosphate, thymine, adenine, inosine, cyclic guanosine monophosphate, hypoxanthine and xanthine were evaluated. Uric acid and the last two were the only compounds detectable in measurable amounts in aqueous humor and in plasma of all patients. Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were lower than those of xanthine and than plasma oxypurine levels. In 8 patients, treated with allopurinol, oxypurinol concentrations in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor barrier.. ...
https://iris.uniroma1.it/handle/11573/24626
Aqueous humor synonyms, aqueous humor antonyms - FreeThesaurus.comAqueous humor synonyms, aqueous humor antonyms - FreeThesaurus.com
Synonyms for aqueous humor in Free Thesaurus. Antonyms for aqueous humor. 1 synonym for aqueous humor: aqueous humour. What are synonyms for aqueous humor?
http://www.freethesaurus.com/aqueous+humor
Effects of ion transport and channel-blocking drugs on aqueous humor formation in bovine isolated eye<...Effects of ion transport and channel-blocking drugs on aqueous humor formation in bovine isolated eye<...
TY - JOUR. T1 - Effects of ion transport and channel-blocking drugs on aqueous humor formation in bovine isolated eye. AU - Shahidullah, M.. AU - Wilson, W.S.. AU - Yap, Keng Hung Maurice. AU - To, Chi Ho. AU - Butt, C.. PY - 2002. Y1 - 2002. M3 - Journal article. VL - 43. JO - Investigative Ophthalmology. JF - Investigative Ophthalmology. SN - 0146-0404. IS - 13. M1 - 901. T2 - Association for Research in Vision and Ophthalmology (ARVO). Meeting. Y2 - 1 January 2002. ER - ...
https://research.polyu.edu.hk/en/publications/effects-of-ion-transport-and-channel-blocking-drugs-on-aqueous-hu
Morphine-Stimulated Nitric Oxide Production in Rabbit Aqueous Humor | IOVS | ARVO JournalsMorphine-Stimulated Nitric Oxide Production in Rabbit Aqueous Humor | IOVS | ARVO Journals
Purpose: : Recent studies in our laboratory have demonstrated that nitric oxide plays a role in morphine-induced reduction of intraocular pressure and pupil diameter in New Zealand white (NZW) rabbits. The goal of the present study was to determine the effect of morphine on nitric oxide levels in the aqueous humor of NZW rabbits. Methods: : Normal, dark-adapted (reverse light cycle, 12/12 hr dark/light) NZW rabbit eyes were treated topically and bilaterally as follows: 1) morphine (100 µg) for 5 or 30 minutes; 2) 30 minute pretreatment with naloxone (100 µg; a nonselective opioid receptor antagonist) or L-NAME (0.5 %; a nitric oxide synthase inhibitor), followed by treatment with morphine for 5 or 30 minutes. Aqueous humor samples were obtained by paracenthesis and immediately assayed for nitric oxide (nitrites + nitrates) using a nitric oxide quantitation kit. Results: : The levels of NO in aqueous humor of rabbits treated with morphine for 5 minutes, increased from 34.22 ± 2.22 µM ...
http://iovs.arvojournals.org/article.aspx?articleid=2390027
Influence of non-penetrating glaucoma surgery on aqueous outflow facility in isolated porcine eyes | British Journal of...Influence of non-penetrating glaucoma surgery on aqueous outflow facility in isolated porcine eyes | British Journal of...
Although the resistance to outflow, postoperatively, is probably dependent on the TDM,7 proponents of viscocanalostomy4 advocate tightly suturing the superficial flap in an attempt to avoid subconjunctival filtration. Whether tightly or loosely suturing the flap affects the overall outflow facility changes after NPGS has, to our knowledge, not been investigated before.. We report an in vitro mean preoperative outflow facility in isolated porcine eyes, in line with previously published work.11 The mean (SD) outflow facility after NPGS (1.584 (0.217) μl/min/mm Hg) is relatively lower than previously reported mean outflow facility after trabeculectomy11 (2.957 (0.602) μl/min/mm Hg), which possibly accounts for the gradual decrease in IOP after NPGS, as opposed to the sudden drop in pressure after penetration as in the case of trabeculectomy.. According to McEwen12 a single patent hole of 12 μm is by itself sufficiently large to provide a normal facility of outflow. Based on this we would have ...
http://bjo.bmj.com/content/88/7/950
Aqueous Humor Pharmacokinetics of Dorzolamide Loaded PLGAChitosan Nanoparticles by Ultra Performance Liquid Chromatography |...Aqueous Humor Pharmacokinetics of Dorzolamide Loaded PLGAChitosan Nanoparticles by Ultra Performance Liquid Chromatography |...
Title: Aqueous Humor Pharmacokinetics of Dorzolamide Loaded PLGAChitosan Nanoparticles by Ultra Performance Liquid Chromatography. VOLUME: 7 ISSUE: 3. Author(s):Musarrat H. Warsi, Akash Chaurasiya, Gaurav K. Jain, Shadab A. Pathan, Prakash Chander, Ajeet K. Singh, Sushama Talegaonkar, Farhan J. Ahmad and Roop K. Khar. Affiliation:Department of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110062, India.. Keywords:Aqueous humor, Dorzolamide, Nanoparticles, Ocular pharmacokinetics, Ultra performance liquid chromatography, Ultraviolet (UV) detection, Ocular bioavailability, Limit of detection, Limit of quantification, Assay validation. Abstract: Ocular pharmacokinetic analysis of drugs is useful for evaluation of efficacy of novel ophthalmic formulations. A simple and sensitive ultra performance liquid chromatographic (UPLC) method with ultraviolet (UV) detection was developed and validated for the quantification of dorzolamide (DZA) in rabbit aqueous humor. The aqueous humor ...
https://www.eurekaselect.com/74600/article/aqueous-humor-pharmacokinetics-dorzolamide-loaded-plgachitosan-nanoparticles-ultra
The effect of aqueous humour protein content and viscosity on equilibrium pressure under the scleral flap in trabeculectomies |...The effect of aqueous humour protein content and viscosity on equilibrium pressure under the scleral flap in trabeculectomies |...
Purpose: To look at the influence of aqueous humour protein content and viscosity, which may increase in anterior chamber inflammation, on equilibrium pressure under the scleral flap in trabeculectomies. The influence of suture numbers and scleral flap shapes was also investigated. Methods: Normal and uveitic aqueous humour were represented by plain BSS, BSS containing 300 mg/ 100 ml of albumin and BSS containing 3000 mg/ 100 ml of albumin. Porcine corneoscleral rims were mounted on a Barron artificial anterior chamber and chamber pressure was measured using a pressure transducer. 4 mm x 4 mm partial thickness scleral flaps and 0.75 mm diameter sclerostomies were created, followed by re-suturing of the flap with either 2 or 4 sutures, as in a trabeculectomy. Equilibrium pressure in the chamber was noted. The square scleral flaps were also compared with 4 mm x 3 mm rectangular and 4 mm x 4 mm triangular flaps. In all cases, n = 8. Statistical analysis involved the unpaired t-test and one-way ...
http://iovs.arvojournals.org/article.aspx?articleid=2149646
The Investigation of HCV RNA in Tear Fluid and Aqueous Humor in Patients with Anti-HCV Antibody Positive Who Underwent Cataract...The Investigation of HCV RNA in Tear Fluid and Aqueous Humor in Patients with Anti-HCV Antibody Positive Who Underwent Cataract...
PURPOSE: To obtain aqueous humor and tear fluid samples during cataract surgery of the hepatitis C virus (HCV)-antibody-positive patients in order to analyze them for HCV RNA and compare these measurements with serum HCV RNA levels.. METHODS: Twenty-nine anti-HCV-positive patients were included this study. HCV RNA viral load levels were determined by commercial real-time polymerase chain reaction system. Antibodies to HCV were screened with the enzyme-linked immunosorbent assay (ELISA) using anti-HCV test kit.. RESULTS: Log10 HCV RNA levels were found to be 6.00 ± 1.06 IU/mL in serum, 2.76 ± 0.36 IU/mL in the aqueous humor, and 1.91 ± 0.93 IU/mL in tear fluid. No correlation was detected between samples for HCV RNA positivity (p = .390, κ = .102). We have observed that, viral RNA was detected in the aqueous humor, while not in serum in one case, whereas viral RNA was detected in tear fluid but not in serum in another case.. CONCLUSIONS: Although viral load detected in aqueous humor and tear ...
https://read.qxmd.com/read/25495483/the-investigation-of-hcv-rna-in-tear-fluid-and-aqueous-humor-in-patients-with-anti-hcv-antibody-positive-who-underwent-cataract-surgery
Aqueous humour | Article about aqueous humour by The Free DictionaryAqueous humour | Article about aqueous humour by The Free Dictionary
Looking for aqueous humour? Find out information about aqueous humour. Physiol the watery fluid within the eyeball between the cornea and the lens Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005 Explanation of aqueous humour
https://encyclopedia2.thefreedictionary.com/aqueous+humour
Estudio histopatológico de hígado y riñón de caninos y su relación con las concentraciones de urea, creatinina, proteínas,...Estudio histopatológico de hígado y riñón de caninos y su relación con las concentraciones de urea, creatinina, proteínas,...
GALLARDO, C.; PAREDES, E. e PEREZ, J.. Histopathological study of canine liver and kidney and their relationship with blood and postmortem aqueous humour samples concentrations of urea, creatinine, proteins and enzymes activities (ALT and SAP). Arch. med. vet. [online]. 2003, vol.35, n.1, pp.61-74. ISSN 0301-732X. http://dx.doi.org/10.4067/S0301-732X2003000100006.. The goal of this study was to characterize histopathological lesions of the liver and kidney of canines, and their relationship with blood and postmortem samples of aqueous humor concentrations of urea, creatinine, proteins and ALT and SAP plasmatic activity. Thirty one animals were used in this study. They did not have clinical history of hepatic or renal diseases. Plasma samples were obtained before euthanasia. A sample of aqueous humor was obtained from the right eye of each dog just after euthanasia and a similar sample was obtained 24 hours later from the left eye. Urea, creatinine and protein concentrations and plasmatic ...
https://scielo.conicyt.cl/scielo.php?script=sci_abstract&pid=S0301-732X2003000100006&lng=pt&nrm=iso&tlng=en
Publications | Research groups | Imperial College LondonPublications | Research groups | Imperial College London
Experimental Eye Research, Vol: 127, Pages: 224-235, ISSN: 1096-0007 The bulk of aqueous humor passing through the conventional outflow pathway must cross the inner wall endothelium of Schlemms canal (SC), likely through micron-sized transendothelial pores. SC pore density is reduced in glaucoma, possibly contributing to obstructed aqueous humor outflow and elevated intraocular pressure (IOP). Little is known about the mechanisms of pore formation; however, pores are often observed near dome-like cellular outpouchings known as giant vacuoles (GVs) where significant biomechanical strain acts on SC cells. We hypothesize that biomechanical strain triggers pore formation in SC cells. To test this hypothesis, primary human SC cells were isolated from three non-glaucomatous donors (aged 34, 44 and 68), and seeded on collagen-coated elastic membranes held within a membrane stretching device. Membranes were then exposed to 0%, 10% or 20% equibiaxial strain, and the cells were aldehyde-fixed 5 min after ...
http://www.imperial.ac.uk/ocular-biomechanics/publications/
Studying aqueous humour outflow with aqueous angiography | OphthalmologyTimesStudying aqueous humour outflow with aqueous angiography | OphthalmologyTimes
A pioneering dye-based technique that enables aqueous humour outflow to be studied has the potential to improve glaucoma angle-based procedures and surgery outcomes.
http://ophthalmologytimes.modernmedicine.com/ophthalmologytimes/news/studying-aqueous-humour-outflow-aqueous-angiography?page=1,3
Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucoma<...
TY - JOUR. T1 - Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucoma. AU - Kim, Jaeryung. AU - Park, Dae Young. AU - Bae, Hosung. AU - Park, Do Young. AU - Kim, Dongkyu. AU - Lee, Choong Kun. AU - Song, Sukhyun. AU - Chung, Tae Young. AU - Lim, Dong Hui. AU - Kubota, Yoshiaki. AU - Hong, Young Kwon. AU - He, Yulong. AU - Augustin, Hellmut G.. AU - Oliver, Guillermo. AU - Koh, Gou Young. PY - 2017/10/2. Y1 - 2017/10/2. N2 - Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also ...
https://www.scholars.northwestern.edu/en/publications/impaired-angiopoietintie2-signaling-compromises-schlemms-canal-in
JCI - All TIEd up: mechanisms of Schlemms canal maintenanceJCI - All TIEd up: mechanisms of Schlemms canal maintenance
Glaucoma is a leading cause of blindness, with an estimated world-wide prevalence of 3.5% in members of the population older than 40 years of age. Elevated intraocular pressure as the result of abnormal resistance to aqueous humor drainage is a major contributing, and the only preventable, factor in glaucoma development. Schlemms canal (SC), a lymphatic-like vessel encircling the anterior portion of the eye, plays a key role in promoting aqueous humor outflow and maintenance of normal intraocular pressure. The risk of developing glaucoma increases with age; therefore, understanding mechanisms of SC maintenance and how aging affects SC function are of special importance, both for prevention and novel treatment approaches to glaucoma. Using a compelling array of genetic models, Kim et al. report in this issue of the JCI that continuous angiopoietin/TIE2 signaling is required for maintaining SC identity and integrity during adulthood and show that its age-related changes can be rescued by a TIE2 ...
https://j8k9.com.www.mobile.jci.org/articles/view/96840/figure/1
Changes to the Aqueous Humor Proteome during Glaucoma. | Physicians Weekly for Medical News, Journals & ArticlesChanges to the Aqueous Humor Proteome during Glaucoma. | Physicians Weekly for Medical News, Journals & Articles
Expression levels of 87 proteins were found to be different between glaucomatous and control aqueous humor. Of the 87 proteins, 34 were significantly upregulated, whereas 53 proteins were downregulated in the aqueous humor from glaucoma patients compared to controls. Differentially expressed proteins were found to be involved in cholesterol-related, inflammatory, metabolic, antioxidant as well as proteolysis-related processes.. CONCLUSION ...
https://www.physiciansweekly.com/changes-to-the-aqueous-humor-proteome-during-glaucoma/
Mohammad Shahidullah, DVM, PhD | physiology.ahsc.arizona.eduMohammad Shahidullah, DVM, PhD | physiology.ahsc.arizona.edu
In the anterior part of our eye there are two cavities filled with a watery but nutritive fluid called aqueous humor. One cavity, called the anterior chamber, lies just behind the cornea and in front of the iris. The other, called the posterior chamber, is a narrow space behind the iris and is surrounded by a mucsuloepithelial structure called the ciliary body. Aqueous humor is contiuously formed into the posterior chamber by the double layer ciliary epithelium that covers the ciliary body. Aqueous humor then sips through the hole at the center of iris, called the pupil, into the anterior chamber. Excess aqueous humor leaves the anterior chamber, by a pressure dependent way, mainly through a sieve-like structure called the trabecular meshwork located at the junction of the cornea and the sclera. Apart from supplying the nutrients and removing metabolic wastes from the avascular tissues of the eye, namely, the cornea, trabecular meshwork and the lens, the aqueous humor maintains the optimum ...
https://physiology.arizona.edu/person/mohammad-shahidullah-dvm-phd
Glossary of the EyeGlossary of the Eye
accommodation: ability of the lens to adjust its shape for vision at various distances in order to produce a clear image on the retina.. anterior chamber: space in front portion of the eye between the cornea and the iris and lens, which is filled with aqueous humor. aqueous humor: clear, watery fluid that fills the anterior chamber and the posterior chamber in the front part of the eye and provides nutrients to structures in the anterior chamber.. aqueous outflow pathway: the main exit route of aqueous humor from the eye, including the trabecular meshwork and Schlemms canal.. astigmatism: irregular curvature of the cornea or lens resulting in a distorted image because light rays are not focused on a single point on the retina.. binocular vision: coordinated use of the two eyes to see a single fused three-dimensional image.. blindspot: in testing the visual field, this is the blind area corresponding to the optic disk where the optic nerve fibers exit the eye and where there are no ...
https://www.zeitereye.com/resources/glossary-of-the-eye/
JCI - Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucomaJCI - Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucoma
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood. Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all hallmarks of POAG in humans. We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, ...
https://j8k9.com.www.mobile.jci.org/articles/view/94668/figure/1
JCI - Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucomaJCI - Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucoma
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood. Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all hallmarks of POAG in humans. We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, ...
https://www.jci.org/articles/view/94668/figure/11
shock humour wikipedia shqip - Yahoo Search Resultsshock humour wikipedia shqip - Yahoo Search Results
Humour is often used to make light of difficult or stressful situations and to brighten up a social atmosphere in general. It is regarded by many as an enjoyable and positive experience, so it would be reasonable to assume that it might have some positive physiological effects on the body. A study designed to test the positive physiological effects of humour, the relationship between being exposed to humour and pain tolerance in particular, was conducted in 1994 by Karen Zwyer, Barbara Velker, and Willibald Ruch. To test the effects of humour on pain tolerance the test subjects were first exposed to a short humorous video clip and then exposed to the cold pressor test. To identify the aspects of humour which might contribute to an increase in pain tolerance the study separated its fifty-six female participants into three groups, cheerfulness, exhilaration and humour production. The subjects were further separated into two groups, high Trait-Cheerfulness and high Trait-Seriousness ac... ...
https://search.yahoo.com/mobile/s?p=shock+humour+wikipedia+shqip&ei=UTF-8&_tsrc=apple&age=1m&fr2=p%3As%2Cv%3Aw%2Cm%3Ars-bottom
Relationship between the severity of macular edema and | Open-iRelationship between the severity of macular edema and | Open-i
Relationship between the severity of macular edema and the aqueous humour concentrations of cytokines.A. IL-1β. B. IL-6. C. IL-8. D. IP-10. E. MCP-1. F. VEGF.
https://openi.nlm.nih.gov/detailedresult.php?img=PMC4414516_pone.0125329.g002&req=4
х ф Величайший шоумен o d q (Page 1) - Art Atau Seni - Forum Judi
J Room Physiol 143:439В444 de Carvalho EF, de Castro FT, Rondinelli E, Carvalho JF (1994) Physiological aspects of Trypanosoma cruzi gene control during heat-shock. P2X4 receptors induced in spinal microglia barrier tactile allodynia after tenacity injury. 1 pct of men and 21 buy 5 mg proscar with visa prostate cancer questions. In its original 2 years, the GOG was in discus- sions with the Childrens Oncology Set (RATCHET) to col- laborate on a usage for the benefit of scrutiny inasmuch as low-risk disease and compressed BEP repayment for intermediate-risk disease. They like using toys in behalf of their intended tenacity as beyond the shadow of a doubt as for whatever invented ambition they can imagine. You pot motley this likewise cheap super cialis 80 mg free shipping erectile dysfunction medication australia. Peak aqueous humor concentrations of triamcinolone ranged from 2,151 to 7,202 ng/mL, half-life 76В635 h, and AUC0Вt 231 to 1,911 ng h/mL following celibate intravitreal ...
http://forumjudi.site/viewtopic.php?pid=136871
Etanercept treatment in the endotoxin-induced uveitis of rats | AVESİSEtanercept treatment in the endotoxin-induced uveitis of rats | AVESİS
This study was conducted to investigate therapeutic value of a soluble tumor necrosis factor-alpha (TNF-alpha) receptor, etanercept, in a rat model of endotoxin-induced uveitis (EIU). Forty-two inbred male Lewis rats were divided into seven equal groups. 200 mug of Escherichia coli 055:1355 lipopolysaccharide, (LPS) was injected in one hind footpad of the Groups 2, 3, 4, 5, 6, and 7 rats. Group 5, 6, and 7 rats also received subcutaneous etanercept 24 hr prior to LPS injection at a dose of 0(.)4 mg kg(-1). Group 1 rats were used as controls. Eight, 24, and 48 hr after treatment clinical uvetis scores (miosis, iris hyperemia, and hypopyon) were assessed by a masked observer and the rats were euthanized. Neutrophil leukocytes, CD8 +, CD4 +, and CD45RO + cells in the anterior uveal tissue were counted either after hematoxylin-eosin or monoclonal antibody staining. TNF-alpha. levels were also measured in the aqueous humor samples by an ELISA method. Etanercept treatment significantly improved ...
https://avesis.ktu.edu.tr/yayin/177b308d-f9e3-4e02-8935-e0da82f13f57/etanercept-treatment-in-the-endotoxin-induced-uveitis-of-rats
Rev. Christopher Leighton to begin Week Six with discussion of humors challenges - The Chautauquan DailyRev. Christopher Leighton to begin Week Six with discussion of humors challenges - The Chautauquan Daily
Part of Leightons lecture will include teasing the humor out of the New Testament. The story in Matthew 8:28-34, in which Jesus drives demons out of two men and into a herd of pigs that immediately run off the edge of a cliff and drown, will be the conduit through which Leighton will explore the edge of humor. He said he likes using that story because humor is about exorcising our demons.. Humor can bring to light whats wrong with our society and can help us learn to laugh at ourselves, Leighton said, but it can also demean and denigrate people and kill compassion. Leighton, an ordained Presbyterian minister, said he cant make generalizations for all of Christianity.. (The lecture is) one Christians take on the challenges (of humor), Leighton said. Its Christian in the sense that Im trying to access resources within my own tradition to understand how humor works.. Leightons journey with studying interfaith humor began in 2013 when the ICJS decided to expand its educational mission ...
https://chqdaily.com/2017/07/rev-christopher-leighton-begin-week-six-discussion-humors-challenges/
Glaucoma - 24/7 Emergency and Specialty Veterinary HospitalGlaucoma - 24/7 Emergency and Specialty Veterinary Hospital
Glaucoma is a disease of the eye where there is an increase in the pressure within the eye, this is called the intraocular pressure. This disease can be quite painful and will often result in blindness. An increase in intraocular pressure is caused by the globe of the eye being unable to drain. Inside the eye is the ciliary body, this structure not only contains the ligaments that hold the lens in place and helps it focus it also produces aqueous humor. Aqueous humor is a fluid that provides nutrition to the eye, helps the eye maintain its shape due and provides the intraocular pressure of the eye. Aqueous humor is located in the anterior chamber of the eye which is the front most chamber between the cornea and the iris. This fluid is being constantly produced by the ciliary body, in order to maintain homeostasis in the eye it must drain at a commensurate rate. The area where drainage occurs is called the iridocorneal angle. When the eyes drainage of aqueous humor does not keep up with its ...
https://www.mtnwestvet.com/index.php/glaucoma/
Medical Advisor Journals, Kyle J. Norton Site, Health Tips for Better Living and Living Health: (Preview) Most Common Diseases...
The most critical risk factor for optic nerve damage in cases of primary open-angle glaucoma (POAG)(31) is an increased intraocular pressure (IOP) due to alternation of tissues in the eye located around the base of the cornea(32). Actin, a critical player in many cellular functions, including cell motility and the maintenance of cell shape, etc.(33), disruption or taken over actin cytoskeleton by numerous pathogens(34), may induce a resistance to aqueous humor outflow in the trabecular meshwork (TM)(36), an area of tissue is responsible for draining the aqueous humor from the eye via the anterior chamber causes of optic nerve damage involved connective tissue growth factor (CTGF), found in higher amounts in the aqueous humor of patients with POAG(35 ...
https://kylejnorton.blogspot.com/2015/01/preview-most-common-diseases-of-ages-of_11.html
Humour as defence against the anxiety manifesting in diversity experiencesHumour as defence against the anxiety manifesting in diversity experiences
Orientation: Using humour in diversity contexts may relieve tension temporarily, but it happens at the expense of someone and indicates a defence against an unconscious anxiety dynamic. Research purpose: The purpose of this research was to describe the manifestation of humour as a defence mechanism against diversity anxiety. Motivation for the research: In working with diversity dynamics in South African organisations, consultants and participants often do not take humour seriously, let alone interpret the accompanying dynamic aspects. Working below the surface with humour may elicit much more and typical diversity dynamics worth investigating. Research design, approach and method: The research design was qualitative and descriptive, using multiple case studies and content analysis. Main findings: Humour is used as a defence against the anxiety experienced in diversity contexts caused by fear of the unknown within the self and the projection of the fear onto another identity group. ...
http://uir.unisa.ac.za/handle/10500/12782
Injecting humour into safety messages can increase effectiveness | Canadian Occupational SafetyInjecting humour into safety messages can increase effectiveness | Canadian Occupational Safety
Its not just what we say that matters, but how we say it when it comes to building a great, safe culture, said Kerr. Humour makes people more approachable; it helps build connections and relationships and break down walls. Humour not only helps messages stand out, relevant humour reduces the counter-argument part of the brain - that part of peoples brains where they immediately start building arguments about why they are not going to do something - so people are more accepting of a message, said Kerr.. If you deliver a message, a rule, a regulation, a safety policy with a little bit of humour, studies show people are five times more likely to go along with you if you do it in a funny way, he said.. Some ways to do this are by using a top 10 list, opening with a funny story, using humour in safety videos - just doing something to add a little bit of humour into the mix.. We need to make sure we are coming up with creative opportunities to share our messages in more fun ways so we are truly ...
http://www.cos-mag.com/safety-leadership-culture/31497-injecting-humour-into-safety-messages-can-increase-effectiveness/
World Glaucoma Association » Advances in aqueous humor dynamicsWorld Glaucoma Association » Advances in aqueous humor dynamics
WGA#One is your gateway to the World Glaucoma Association. With a WGA#One account you can access knowledge resources and join our community ...
https://wga.one/wga-video/advances-in-aqueous-humor-dynamics/
Glaucoma Surgery - namelasikGlaucoma Surgery - namelasik
Trabeculectomy is a surgical procedure recommended for patients with glaucoma that continues to progress despite use of medications and/or laser treatments and to relieve intraocular pressure by removing part of the eyes trabecular meshwork and adjacent structures. It is the most common glaucoma surgery performed and allows drainage of aqueous humor from within the eye to underneath the conjunctiva where it is absorbed. This provides an alternative method of aqueous humor filtration when the natural trabecular outflow pathway is blocked or poorly functioning. This outpatient procedure is performed under topical.. ...
https://namericanlasik.ae/glaucoma-surgery/
Both Hands Gram-Positive :: Q Fever! - MEDICAL HUMOR, medical satire, medical news, healthcare humor, doctor humor, nursing...
Disclaimer: This is a medical humor and parody website meant solely for entertainment purposes, and is not intended to recommend or advise regarding the prevention, diagnosis, or treatment of any medical illness or condition. Stories and articles are meant only to provide a brief, fleeting distraction from the wretchedness of reality, and are not intended to be insensitive, callous, or offensive, or to otherwise belittle the plight of those affected with any medical disease, condition, or illness. All names and descriptions of people are fictitious except for those of well-known public figures, who are the subject of satire. Any resemblance to actual persons or events is purely coincidental. Medical Humor is just that: Medical Humor.. ...
http://www.qfever.com/2001/08/01/both-hands-gram-positive/
Humor for good health or Coping with Grace and Smile Presented by: Michael Brodie, MBA, NHA. - ppt downloadHumor for good health or Coping with Grace and Smile Presented by: Michael Brodie, MBA, NHA. - ppt download
Objectives Improve understanding of positive and negative humor. Increase knowledge of how humor affects our physical, psychological and social wellbeing. Focus on the use of humor for persons with Short Term Memory Loss, and their caregivers. Set out techniques to improve utilization of humor and exposure to humor in daily life. Laugh and tell a few illustrative jokes.
http://slideplayer.com/slide/4059044/
The Short Humour (Humor) Site - Mortality by Doug HawleyThe Short Humour (Humor) Site - Mortality by Doug Hawley
The Short Humour (Humor) Site aims to promote the reading and writing of Short Humour (Humor) both in Britain and throughout the world and also to showcase work by writers of the genre.
http://www.short-humour.org.uk/8writersshowcase/mortality.htm
Cardinal humours synonyms, cardinal humours antonyms - FreeThesaurus.comCardinal humours synonyms, cardinal humours antonyms - FreeThesaurus.com
Synonyms for cardinal humours in Free Thesaurus. Antonyms for cardinal humours. 54 synonyms for humour: comedy, funniness, fun, amusement, funny side, jocularity, facetiousness, ludicrousness, drollery, comical aspect, mood, spirits, temper. What are synonyms for cardinal humours?
https://www.freethesaurus.com/cardinal+humours
Komparativna analiza genske varijabilnosti i nivoa cirkulišućih faktora nekroze tumora, HSP 70 i Fas/FasL u primarnom glaukomu...Komparativna analiza genske varijabilnosti i nivoa cirkulišućih faktora nekroze tumora, HSP 70 i Fas/FasL u primarnom glaukomu...
Genetic heterogeneity of primary open-angle glaucoma, and concentration changes of various inflammation and immune response mediators in the blood, aqueous humor or tissues, indicate the involvement of different genetic mechanisms and immune system activity in the pathogenesis of POAG. The aim of study was to determine the interdependent clinical, genetic and biochemical findings in POAG-HTG patients. Distribution of genetic polymorphisms for TNF-α -308 G/A and - 863 C/A in DNA samples was examined using PCR-RFLP, the concentrations of circulating TNF-α and HSP 70 in a plasma and concentration of sFas and sFasL in the aqueous humor were measured by commercial ELISA tests. Their association with quantitative clinical parameters was examined. This study included 357 subjects: 81 POAG-HTG, 35 PEXG, 77 with senile cataract and 164 healthy subjects age-sex matched. Furthermore, 35 samples of aqueous humor of POAG-HTG patients , 24 PEXG and 29 with senile cataract were treated. The results s...howed ...
https://nardus.mpn.gov.rs/handle/123456789/7212
Patent US8617094 - Fluid infusion methods for glaucoma treatment - Google PatentPatent US8617094 - Fluid infusion methods for glaucoma treatment - Google Patent
Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye
http://www.google.se/patents/US8617094
Patent US6827699 - Shunt device and method for treating glaucoma - Google PatentsPatent US6827699 - Shunt device and method for treating glaucoma - Google Patents
Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemms canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemms canal.
http://www.google.com/patents/US6827699?dq=6981235
Glaucoma | Southern Eye AssociatesGlaucoma | Southern Eye Associates
The healthy eye is filled with a clear fluid called aqueous humor which circulates inside the front portion of your eye. Your eye continually produces a small amount of aqueous humor while an equal amount flows out of your eye in order to maintain a constant healthy eye pressure. Glaucoma means that the aqueous humor is not flowing out of your eye properly and that pressure in the eye is building up. This pressure can cause damage to your optic nerve over time.. Early detection is key with glaucoma. People of any age with glaucoma symptoms or glaucoma risk factors, such as diabetes, family history of glaucoma, or those of African descent, should see an ophthalmologist regularly.. ...
https://southern-eye.com/service/glaucoma/
Humor in Counseling: Maximizing a Therapeutic ToolHumor in Counseling: Maximizing a Therapeutic Tool
Humor is a way of helping clients if used properly and with care. This session will look at various forms of humor and how they may be employed in therapeutic ways with clients to enhance their mental health and help them gain new perspectives on life. Different ways that humor may be introduced...
https://aca.digitellinc.com/aca/sessions/4470/view
CHILDRENS HUMOR STUDY | Center for Interdisciplinary Brain Sciences Research | Stanford MedicineCHILDRENS HUMOR STUDY | Center for Interdisciplinary Brain Sciences Research | Stanford Medicine
Thank you for visiting us at the Childrens Humor Study!. We would like to invite you and your child to consider participation in an exciting new research study to increase our understanding of the development of humor.. In this study we aim to examine the brain development and function, specifically as it relates to cognition and humor. We are currently seeking typically-developing children (ages 6-12) who are native English-speakers. For more information about our research findings related to humor in adults, please read our labs publications. If you are interested in learning more abour our current study, please read through this website.. Study Goals:. This study is directed by Drs. Allan Reiss (Stanford University) and Jessica Black (Boston College). The goals of the study are to:. ...
http://cibsr.stanford.edu/research/previous-studies/humor.html
Value of PCR for Detection of Toxoplasma gondii in Aqueous Humor and Blood Samples from Immunocompetent Patients with Ocular...Value of PCR for Detection of Toxoplasma gondii in Aqueous Humor and Blood Samples from Immunocompetent Patients with Ocular...
We report here the results of our experience with the use of PCR for the identification of T. gondii in blood and aqueous humor samples from patients with and without ocular toxoplasmosis. Currently, the clinical diagnosis of ocular toxoplasmosis is based on the observation of a necrotizing lesion on the fundus, response to treatment, and serologic determination. However, in cases of atypical retinitis or when the fundus is hidden by vitreal inflammation, establishment of a diagnosis by ophthalmological examination alone can be difficult. In such cases the aqueous humor analysis may be used as a diagnostic tool for confirmation of ocular toxoplasmosis. Determination of intraocular production of antitoxoplasmic antibodies has been performed previously, but the results obtained had erratic values (2, 21). PCR has mostly been used to detect T. gondii in different biological samples (4, 9, 12, 14,19). Aqueous humor samples from patients with ocular toxoplasmosis have also been used with the PCR ...
https://jcm.asm.org/content/37/11/3465
Relationship between glaucoma and selenium levels in plasma and aqueous humour | British Journal of OphthalmologyRelationship between glaucoma and selenium levels in plasma and aqueous humour | British Journal of Ophthalmology
Aim: The aim of the study was to compare selenium levels in plasma and aqueous humour in subjects with and without primary open-angle glaucoma (POAG).. Methods: Forty-seven POAG cases and 54 controls in this case-control study were recruited from surgery patients at the University Physicians Ophthalmology Clinic in Tucson, Arizona, USA. Aqueous humour and plasma selenium were determined by high-performance liquid chromatography ion channel plasma mass spectrometry (HPLC ICP-MS). Potential confounders were assessed via a questionnaire. Biological samples were collected and processed at surgery and analysed for selenium content after collection was complete. Outcome measures included the odds of glaucoma in relationship to plasma selenium, aqueous humour selenium, and the ratio of levels of aqueous humour selenium to plasma selenium.. Results: Tertile of selenium and its relationship to POAG was examined. After adjustment for common glaucoma risk factors, the odds of glaucoma in the highest ...
https://bjo.bmj.com/content/93/9/1155
The comparison of topical ibopamine 2% with tonography to identify the outflow resistance in eyes with ocular hypertension |...
Background: To evaluate the ability of topical ibopamine 2% to detect outflow resistance by comparing it with the tonography test in eyes with ocular hypertension (OHT). Methods: 62 eyes with OHT and 33 control eyes were included in this prospective study. Tonography was done manually as a standard outflow facility measurement. We used a C value of 0.18 mu l/min/ mm Hg or less and a P-o/C value of 100 and above as a positive tonographic test. The ibopamine test performed on the following day was considered positive if there was an intraocular pressure (IOP) change of at least 3 mm Hg. Results: The sensitivity of the tonography and ibopamine tests was 69 and 53%, respectively, in eyes with OHT. The specificity of both tests was 97%. Although the sensitivity of the tonography test is higher than that of the ibopamine test, the difference between both was not statistically significant in these eyes ( p = 0.409). Positive results in tonography were associated with higher IOP, while the results were ...
https://avesis.inonu.edu.tr/yayin/39bf8e1d-2c0f-4843-ad4c-b0396d89875a/the-comparison-of-topical-ibopamine-2-with-tonography-to-identify-the-outflow-resistance-in-eyes-with-ocular-hypertension
Significant variation of the elevated nitric oxide levels in aqueous humor from patients with different types of glaucoma<...
TY - JOUR. T1 - Significant variation of the elevated nitric oxide levels in aqueous humor from patients with different types of glaucoma. AU - Tsai, Der Chong. AU - Hsu, Wen-Ming. AU - Chou, Ching Kuang. AU - Chen, Shih Jen. AU - Peng, Chi Hsien. AU - Chi, N. Wen. AU - Ho, Larry L.T.. AU - Liu, Jorn Hon. AU - Chiou, Shih Hwa. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Though several studies have shown that the biochemical function of nitric oxide (NO) in the eye might play an important role in the regulation of intraocular pressure (IOP), local control of ocular blood flow and loss of retinal ganglion cells by apoptosis, it is unclear whether the role of NO is similar in the pathogenesis of different kinds of glaucoma: primary open-angle glaucoma (POAG), chronic closed-angle glaucoma (CCAG) and neovascular glaucoma (NVG). To further explore this issue, we measured the concentrations of NO in aqueous humor and plasma samples from patients with POAG (n = 31 ), CCAG (n = 76), NVG (n = 8) and cataract (n ...
https://tmu.pure.elsevier.com/en/publications/significant-variation-of-the-elevated-nitric-oxide-levels-in-aque
Experimental research on intraocular aqueous flow by PIV method | BioMedical Engineering OnLine | Full TextExperimental research on intraocular aqueous flow by PIV method | BioMedical Engineering OnLine | Full Text
Aqueous humor flows regularly from posterior chamber to anterior chamber, and this flow much involves intraocular pressure, the eye tissue nutrition and metabolism. To visualize and measure the intraocular flow regular pattern of aqueous humor. Intraocular flow in the vitro eyeball is driven to simulate the physiological aqueous humor flow, and the flow field is measured by Particle Image Velocimetry(PIV). Fluorescent particle solution of a certain concentration was infused into the root of Posterior Chamber(PC) of vitro rabbit eye to simulate the generation of aqueous and was drained out at a certain hydrostatic pressure from the angle of Anterior Chamber(AC) to represent the drainage of aqueous. PIV method was used to record and calculate the flow on the midsagittal plane of the eyeball. Velocity vector distribution in AC has been obtained, and the distribution shows symmetry feature to some extent. Fluorescent particle solution first fills the PC as it is continuously infused, then surges into AC
https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/1475-925X-12-108
2014 Healthy Humor Honors Award - Jill Knox - Invisible Disabilities® Association2014 Healthy Humor Honors Award - Jill Knox - Invisible Disabilities® Association
Jill Knox has been selected to be the 2014 recipient of the Invisible Disabilities Associations Healthy Humor Award. Jill has been chosen for her leadership as President of the Association for Applied and Therapeutic Humor (AATH). Thank you for serving a community of professionals who help practice and promote healthy humor and laughter oftentimes in the midst of illness, pain and tragedy.. The Association for Applied and Therapeutic Humor is an international non-profit organization of humor and laughter enthusiasts whose mission is to serve as a community of professionals dedicated to the study, practice, and promotion of healthy humor and laughter. The theme of Jills presidency is Humor for Peace, knowing that humor and laughter are gateways to a more peaceful world.. As an educator, Jills use of humor in the classroom led her to a career as a speaker and founder of The Sunnyside, providing workshops and keynotes which emphasize the power of humor in the workplace and in daily living. She ...
https://invisibledisabilities.org/award-recipients/2014-ida-honor-awards-recipients/2014-healthy-humor-honors-award-jill-knox-association-of-applied-and-therapeutic-humor-aath/
Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork |...Microstructure visualization of conventional outflow pathway and finite element modeling analysis of trabecular meshwork |...
In our study, 2PM was used to image the trabecular drainage channels of intact enucleated rat eyes. Due to the intrinsic properties of drainage tissue, autofluorescence from collagen fibers can be used to image the microstructure of the pathway. Compared to external fluorescent label, autofluorescence can avoid tissue damage caused by fluorochrome. Meanwhile, 2PM is suited to tissue imaging under the sclera, and has been successfully used to image living skin at a depth of 350 μm by visualizing the 2PAF of the skins extracellular matrix and melanin [19]. Most importantly of all, we were able to successfully get the high resolution images under high scattering tissue of eye. Our imaging had a lateral resolution of 2 μm, and a depth resolution of 1 μm. It is found that the high resolution imaging can achieve resolution of tissue section, and can avoid tissue distortions caused by infusion of fixatives.. Aqueous humor drains into aqueous vein through TM region firstly. In this progress, TM and ...
https://biomedical-engineering-online.biomedcentral.com/articles/10.1186/s12938-016-0254-2
Glaucoma - BioSolutionsGlaucoma - BioSolutions
The major risk factor for most glaucomas and focus of modeling and treatment is increased intraocular pressure. Intraocular pressure is a function of production of liquid aqueous humor by the ciliary body of the eye and its drainage through the trabecular meshwork. Aqueous humor flows from the ciliary bodies into the posterior chamber, bounded posteriorly by the lens and the zonule of Zinn and anteriorly by the iris. It then flows through the pupil of the iris into the anterior chamber, bounded posteriorly by the iris and anteriorly by the cornea. From here the trabecular meshwork drains aqueous humor via Schlemms canal into scleral plexuses and general blood circulation. In open angle glaucoma there is reduced flow through the trabecular meshwork; in angle closure glaucoma, the iris is pushed forward against the trabecular meshwork, blocking fluid from escaping ...
https://bioisolutions.blogspot.com/2008/11/glaucoma.html
Humor in Language - Oxford Research Encyclopedia of LinguisticsHumor in Language - Oxford Research Encyclopedia of Linguistics
Interest in the linguistics of humor is widespread and dates since classical times. Several theoretical models have been proposed to describe and explain the function of humor in language. The most widely adopted one, the semantic-script theory of humor, was presented by Victor Raskin, in 1985. Its expansion, to incorporate a broader gamut of information, is known as the General Theory of Verbal Humor. Other approaches are emerging, especially in cognitive and corpus linguistics. Within applied linguistics, the predominant approach is analysis of conversation and discourse, with a focus on the disparate functions of humor in conversation. Speakers may use humor pro-socially, to build in-group solidarity, or anti-socially, to exclude and denigrate the targets of the humor. Most of the research has focused on how humor is co-constructed and used among friends, and how speakers support it. Increasingly, corpus-supported research is beginning to reshape the field, introducing quantitative concerns, as well
http://linguistics.oxfordre.com/view/10.1093/acrefore/9780199384655.001.0001/acrefore-9780199384655-e-342?rskey=h74vVR&result=3
Function of Humour in Roman Verse Satire: Laughing and Lying - Oxford ScholarshipFunction of Humour in Roman Verse Satire: Laughing and Lying - Oxford Scholarship
Our image of Roman satire has developed from that of a static, moralizing genre to a deliberately complex form, but our approach to the humour intrinsic to satire has not developed accordingly. This book offers a comprehensive new analysis of humour in the writings of Horace, Persius, and Juvenal, with an excursus to Lucilius. The main thesis is that far from being an external means of sweetening the moral lesson, humour lies at the heart of Roman satire and shapes its paradoxical essence. The book argues that while the satirist needs humour for the aesthetic merit of his work, his ideological message inevitably suffers from the ambivalence that humour carries. By analyzing object-oriented humour, humour directed at the speaker (including self-irony), and humour directed at neither object nor subject, the book shows how the Roman satirists work round this double mission of morals and merriment. As a result, they present the reader with a much more sprawling and open literary product than they promise
http://www.oxfordscholarship.com/view/10.1093/acprof:oso/9780199281114.001.0001/acprof-9780199281114
Innovations in Glaucoma Surgery: Improving the Results - Universidad de Zaragoza RepositoryInnovations in Glaucoma Surgery: Improving the Results - Universidad de Zaragoza Repository
Glaucoma still represents the most frequent cause of irreversible blindness worldwide. The technological advances lead to innovative surgeries, which are rapidly introduced in clinical practice. New devices to lower intraocular pressure without opening the eye wall, bypassing the trabecular meshwork, or shunting the aqueous humor to the suprachoroidal space have been approved undergoing clinical assessment within clinical trials. Currently, other devices under evaluation are showing promising results. Although these methods will increase the options available for glaucoma surgeons, it is unclear if they could replace the present standard surgeries, such as trabeculectomy, deep sclerectomy, and glaucoma drainage devices. Moreover, the standard procedures are continuously modified in different ways to become safer and more effective. In this issue L. Choritz et al. investigate whether increased concentrations of endothelin-1 in the aqueous humor samples of glaucoma patients influenced wound healing and
https://zaguan.unizar.es/record/70676/files/?ln=en
Isoforms of TGF-β in the aqueous humor of patients with pseudoexfoliation syndrome and a possible association with the long...Isoforms of TGF-β in the aqueous humor of patients with pseudoexfoliation syndrome and a possible association with the long...
Read Isoforms of TGF-β in the aqueous humor of patients with pseudoexfoliation syndrome and a possible association with the long-term stability of the capsular bag after cataract surgery, Graefe
https://www.deepdyve.com/lp/springer_journal/isoforms-of-tgf-in-the-aqueous-humor-of-patients-with-U5FLuwvHQc
Drug delivery: from a contact lens to the anterior chamber | Estudo GeralDrug delivery: from a contact lens to the anterior chamber | Estudo Geral
Mathematical models to describe drug concentration profiles of topically administered drug in the anterior chamber aqueous humor have been proposed by several authors. The aim of this paper is to present a mathematical model to predict the drug concentration in the anterior chamber when a therapeutical contact lens with the drug is entrapped in nanoparticles is used ...
https://estudogeral.uc.pt/handle/10316/13704
FM-700FM-700
The FM-700 aqueous flare meter (also known as a Laser Flare Meter) enhances the follow up of patients by enabling the in-vivo measurement of aqueous flare in a non-contact, non-invasive and painless manner. The quantitative and reproducible measurement of aqueous flare it provides is known to be useful in cases of uveitis and following IOL implantation, and increased levels of flare have been reported with many other ocular conditions. This latest generation of the Kowa aqueous flare meter has been designed to combine the ultimate in efficiency and accuracy providing fast detection of ocular inflammation and subclinical change of inflammation levels ...
http://www.aftaservice.com/Kowa/FM-700.html
Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study -...
Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
http://libros.duhnnae.com/2017/jun8/149821249645-Levels-of-Aqueous-Humor-Trace-Elements-in-Patients-with-Non-Exsudative-Age-related-Macular-Degeneration-A-Case-control-Study.php
Patente EP1310222A3 - Drug-releasing trabecular implant for glaucoma treatment - Google PatentesPatente EP1310222A3 - Drug-releasing trabecular implant for glaucoma treatment - Google Patentes
A device and method are provided for improved treatment of elevated intraocular pressure due to glaucoma. A trabecular shunting device is adapted for implantation within the trabecular meshwork of an eye such that aqueous humor flows controllably from the anterior chamber of the eye to Schlemms canal, bypassing the trabecular meshwork. The trabecular shunting device may utilize a quantity of pharmaceuticals effective in treating glaucoma, which are controllably released from the device into cells of the trabecular meshwork and/or Schlemms canal. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular shunting device such that aqueous flow either increases or decreases as desired. Placement of the trabecular shunting device within the eye, and release of a glaucoma medication therefrom, can arrest or slow the progression of glaucoma.
http://www.google.es/patents/EP1310222A3?cl=en
Ocular Penetration Studies | JAMA Ophthalmology | The JAMA NetworkOcular Penetration Studies | JAMA Ophthalmology | The JAMA Network
This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone
https://jamanetwork.com/journals/jamaophthalmology/article-abstract/628592?redirect=true
EyeWorld | Should you be targeting collector channels with MIGS?
GLAUCOMA Should you be targeting collector channels with MIGS? by Liz Hillman Editorial Co-Director Targeting an area with increased pigmentation and blood reflux into Schlemms canal (red line) adjacent to a blue mark on the cornea (black line) that identified a collector channel Source: Paul Harasymowycz, MD With newer stenting devices bypassing the trabecular meshwork or
https://www.eyeworld.org/should-you-be-targeting-collector-channels-migs
ជំងឺទឹកដក់ក្នុងភ្នែក និង ការថែទាំជំងឺទឹកដក់ក្នុងភ្នែក និង ការថែទាំ
ធម្មតា ការផលិតទឹកក្នុងភ្នែករបស់យើង (Aqueous humour) ចាប់ផ្តើមចេញពីគល់ប្រស្រីភ្នែក (Ciliary body) ដែលជាកន្លែងផលិត បន្ទាប់មកវាហូរមកបន្ទប់ផ្នែកខាងក្រោយ រួចបន្តមកបន្ទប់ភ្នែកខាងមុខ ហើយត្រូវបានស្រូបចេញតាមចម្រោះ Trabecular Meshwork និងបន្តចេញមកតាម បំពង់តូច (Schlemms canal) ហើយចុងបញ្ចប់ជ្រាបតាមសរសៃវ៉ែន (Episcleral vein) ...
http://healthtime.tips/c/1196
Humor, Vampire | Article about Humor, Vampire by The Free DictionaryHumor, Vampire | Article about Humor, Vampire by The Free Dictionary
Looking for Humor, Vampire? Find out information about Humor, Vampire. Mel Brookss Dracula: Dead and Loving It is a prime example of vampire humor. Leslie Neilsen played the hapless Count Dracula. Legendary Dracula actor... Explanation of Humor, Vampire
https://encyclopedia2.thefreedictionary.com/Humor%2C+Vampire
Reduced Outflow Governs Uveitic GlaucomaReduced Outflow Governs Uveitic Glaucoma
A new study shows that patients with glaucoma or ocular hypertension (OHT) and recurrent anterior uveitis have a reduced tonographic outflow-lower than patients without glaucoma or OHT-but an actual aqueous flow that is not statistically any different from patients without glaucoma or OHT. Researchers from St. Thomas Hospital in London divided 92 patients into three groups. Group one had patients with recurrent anterior uveitis (three or more attacks) and were being treated for glaucoma or OHT. Group two patients had experienced previous recurrent anterior uveitis without glaucoma or OHT. The third group, the controls, had no ocular problems and IOP less than 21mm Hg. They found that the tonographic outflow facility was approximately 0.18 in group one, 0.25 in group two and 0.27 in the control group. However, the aqueous flow rate in group one was 2.47μl/min, in group two it was 2.13μl/min and 2.25μl/min in the control. The investigators say this demonstrates that the elevated IOP seen in the ...
https://www.reviewofoptometry.com/news/article/reduced-outflow-governs-uveitic-glaucoma
Alpha herpes virus type and viral load in intraocular fluids in patients with acute retinal necrosis | BMJ Open OphthalmologyAlpha herpes virus type and viral load in intraocular fluids in patients with acute retinal necrosis | BMJ Open Ophthalmology
Of all cases with positive PCR for the herpes virus family in intraocular samples taken between 2007 and 2016, only those with VZV and HSV1 or HSV2 met the criteria for ARN. None of the 12 patients with CMV, one patient with EBV and one patient positive for both viruses, exhibited signs of ARN clinically, which is in keeping with Takase et al.6 Some authors suggest EBV and CMV as possible causes.3 4 19 These viruses usually affect immunocompromised patients and typically have a different clinical picture. Lau et al as well as Hillenkamp et al reported that patients with ARN who tested EBV positive with PCR also were positive for VZV.20 21 Low levels of EBV in conjunction with high levels of VZV has also been reported in cerebrospinal fluid in viral CNS disease.15 In this material, we did not find positivity for multiple viruses in the same sample as none of patients with ARN had CMV DNA in intraocular fluids and the four samples analysed for EBV DNA were also negative. The hypothesis that ARN is ...
https://bmjophth.bmj.com/content/4/1/e000247
It Has Nothing to Do with Age: We Humans Require Humor and Laughter-Part 2It Has Nothing to Do with Age: We Humans Require Humor and Laughter-Part 2
Contemporary research began investigating the physiology and therapeutic effects of humor and in fact some believe that humor accomplishes the same goal as physical exercise. Some humor -laughter research findings are as follows:1. Humor experience leads to arousal of the sympathetic nervous system 2.Epinephrine is a precondition for physiological arousal 3. Arousal as measured by heart rate and skin conduction increases with the intensity of the response to something humorous 4. Laughter increases respiration, oxygen exchange, muscular activity, heart rate , stimulates the cardiovascular system , the sympathetic nervous system and the production of catecholamine 5. Blood-pressure is also reduced in a state similar to that resulting from exercise. 6. Increases in systolic and a diastolic blood-pressure is related to the intensity and length of the laughter .Blood pressure levels decreased after laughter to below pre-laughter levels.7 There is greater coordination of function between the right ...
http://ithasnothingtodowithage.blogspot.com/2013/03/we-humans-require-humor-and-laughter.html
The Satire Project: Why political humour is good for democracy | rabble.caThe Satire Project: Why political humour is good for democracy | rabble.ca
Political humour has always been an important part of the democratic process. For centuries, political cartoons have channeled dissent, lampooned politicians, and even educated readers. Satire can broach uncomfortable topics, shake up rigid beliefs, and make us more receptive to alternatives.. As Ian Ellis writes, Political humour, in the hands of our finest satirists, involves delving and questioning, thereby unveiling truths and alternative perspectives the political establishment would prefer kept hidden and unspoken.. In recent years, the U.S. has seen a major resurgence in political humour with The Daily Show, The Colbert Report, and to a lesser extent Saturday Night Live serving up savage satire to a huge fan base. These political humour shows are producing more than just chuckles. Academics in the US have found that watching these shows actually improves political engagement among audience members. Viewers are more likely to closely follow the events lampooned by the programs, to attend ...
https://rabble.ca/news/2012/10/satire-project-why-political-humour-good-democracy
240 Old Age ideas | humor, bones funny, senior humor240 Old Age ideas | humor, bones funny, senior humor
Jul 24, 2019 - Old age finds us all. It creeps up when we are not expecting it and takes us by surprise, leaving us wondering what is next. Sometimes we are able to look back and see the wisdom, and the humor, of our journey. See more ideas about humor, bones funny, senior humor.
https://hu.pinterest.com/coyotevic/old-age/
Posterior chamber of eyeballPosterior chamber of eyeball
Posterior chamber is an important structure involved in production and circulation of aqueous humor. Aqueous humor produced by ... "Flow of Aqueous Humor". yale. Harpreet Gill, MD Staff Physician, Henry Ford Ophthalmology (Sep 20, 2018). "Phacomorphic ... The block in flow of aqueous from the posterior to the anterior chamber will lead to a condition known as Iris bombe. In this ... Surgical management of Glaucoma due to Iris bombe include making a small hole in the iris which allows passage of aqueous from ...
https://en.wikipedia.org/wiki/Posterior_chamber_of_eyeball
Intraocular pressureIntraocular pressure
Brubaker RF (1991). "Flow of aqueous humor in humans". Invest Ophthalmol Vis Sci. 32 (13): 3145-3166. PMID 1748546. Liu JH, ... the rate of aqueous humour formation in microliters per minute (μL/min) U {\displaystyle U} the resorption of aqueous humour ... During the night, intraocular pressure may not decrease despite the slower production of aqueous humour. Glaucoma patients' 24- ... Intraocular pressure is determined by the production and drainage of aqueous humour by the ciliary body and its drainage via ...
https://en.wikipedia.org/wiki/Intraocular_pressure
Jean MéryJean Méry
Mark, Harry H. (2010). "Aqueous Humor Dynamics in Historical Perspective". Survey of Ophthalmology. 55 (1): 89-100. doi:10.1016 ... he inferred that the aqueous humor was generated behind the lens and suggested that glands he noticed were involved in their ...
https://en.wikipedia.org/wiki/Jean_Méry
Minimally invasive glaucoma surgeryMinimally invasive glaucoma surgery
... a part of the uveoscleral outflow pathway for aqueous humor. The uveoscleral pathway is an important pathway for aqueous ... Aqueous humor is produced in the portion of the eye known as the ciliary body. The ciliary body contains 72 protrusions known ... The trabecular outflow is one of the major outflow pathways for aqueous humor in the eye and has been the target of both ... Toris CB (2008). "Chapter 8: Aqueous Humor Dynamics II - Clinical Studies". Current Topics in Membranes. Heine L (1905). "Die ...
https://en.wikipedia.org/wiki/Minimally_invasive_glaucoma_surgery
Schlemms canalSchlemm's canal
... collects aqueous humor from the anterior chamber. It delivers it into the episcleral blood vessels via aqueous ... It collects aqueous humor from the anterior chamber and delivers it into the episcleral blood vessels. Canaloplasty may be used ... On the inside of the canal, nearest to the aqueous humor, it is covered and held open by the trabecular meshwork. This creates ... Glaucoma may be related to drainage of aqueous humor from the eye. This is mostly related to resistance on the internal surface ...
https://en.wikipedia.org/wiki/Schlemm's_canal
Vitreous chamberVitreous chamber
Vitreous humor Vitreous detachment Aqueous humor Sobotta, Johannes (2011). Sobotta : atlas of human anatomy (15th ed.). München ... This chamber is filled with a thick, clear gel-like substance called the vitreous humor (also vitreous body). The humor plays a ... The vitreous chamber is the space in the eye occupied by vitreous humor. Within the vertebrate eye, there are considered to be ...
https://en.wikipedia.org/wiki/Vitreous_chamber
Prostaglandin analogueProstaglandin analogue
Winkler, NS; Fautsch, MP (2014). "Effects of prostaglandin analogues on aqueous humor outflow pathways". Journal of Ocular ... and subsequent studies found that this was due to increasing the outflow of aqueous humor, mainly by relaxing the ciliary ...
https://en.wikipedia.org/wiki/Prostaglandin_analogue
Rajko IgićRajko Igić
Metabolism of angiotensin I by guinea pig aqueous humor. Can J Physiol Pharmacol 2001;79:627-30. Igić R, Behnia R. Properties ...
https://en.wikipedia.org/wiki/Rajko_Igić
Glaucoma valveGlaucoma valve
Eye surgery Glaucoma surgery Brubaker, Richard F. (1991-12-01). "Flow of Aqueous Humor in Humans [The Friedenwald Lecture]". ... Foo VH, Htoon HM, Welsbie DS, Perera SA (2019). "Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma". ... are transscleral implants to channel aqueous humor into the non-dissected Tenon's space, creating a subconjunctival drainage ... due to the ongoing scarring over the conjunctival dissipation segment of the shunt may become too thick for the aqueous humor ...
https://en.wikipedia.org/wiki/Glaucoma_valve
Μ-opioid receptorΜ-opioid receptor
Dortch-Carnes J, Russell K (January 2007). "Morphine-stimulated nitric oxide release in rabbit aqueous humor". Experimental Eye ...
https://en.wikipedia.org/wiki/Μ-opioid_receptor
ApraclonidineApraclonidine
Toris, C. B.; Tafoya, M. E.; Camras, C. B.; Yablonski, M. E. (1995). "Effects of Apraclonidine on Aqueous Humor Dynamics in ...
https://en.wikipedia.org/wiki/Apraclonidine
Glaucoma surgeryGlaucoma surgery
Scar formation at the site of excision or operation may block aqueous humor circulation, while healthy tissue regeneration will ... Certain cells within the eye's ciliary body produce aqueous humor. A ciliary destructive or cyclodestructive procedure is one ... that facilitate the escape of excess aqueous humor from the eye to lower intraocular pressure, and a few that lower IOP by ... A surgical goniotomy involves cutting the fibers of the trabecular meshwork to allow aqueous fluid to flow more freely from the ...
https://en.wikipedia.org/wiki/Glaucoma_surgery
Optic nerveOptic nerve
The trabecular meshwork assists the drainage of aqueous humor fluid. The presence of excess aqueous humor, increases IOP, ...
https://en.wikipedia.org/wiki/Optic_nerve
BrimonidineBrimonidine
When applied to the eye it works by decreasing the amount of aqueous humor made while increasing the amount that drains from ... Toris CB, Camras CB, Yablonski ME (July 1999). "Acute versus chronic effects of brimonidine on aqueous humor dynamics in ocular ... This vasoconstriction may explain the acute reduction in aqueous humor flow. The increased uveoscleral outflow from prolonged ... This reduces cAMP and hence aqueous humour production by the ciliary body. Peripheral α2 agonist activity results in ...
https://en.wikipedia.org/wiki/Brimonidine
FlunixinFlunixin
"Distribution of flunixin meglumine and firocoxib into aqueous humor of horses". Journal of Veterinary Internal Medicine. 25 (5 ...
https://en.wikipedia.org/wiki/Flunixin
Florian VerreyFlorian Verrey
Clinic on aqueous humor pathology. L'humeur aqueuse et ses fonctions, (with Marc Amsler and Alfred Huber, 1955) - Aqueous humor ... He was the author of 74 medical papers, many of which concerned the eye's aqueous humor. He was also interested in uveitis; in ...
https://en.wikipedia.org/wiki/Florian_Verrey
Ocular ischemic syndromeOcular ischemic syndrome
Additional measures include paracentesis of aqueous humor to decrease IOP acutely. An ESR should be drawn to detect possible ...
https://en.wikipedia.org/wiki/Ocular_ischemic_syndrome
IbopamineIbopamine
So ibopamine can not be found in the aqueous humor after instillation. After being hydrolysed to epinine, ibopamine is able to ... It has been shown that the half-life of ibopamine is short to about 2 minutes in the aqueous humour owing to the fast ... Due to the esterases existing in the aqueous humour and ocular tissues, ibopamine can be rapidly hydrolysed to epinine which is ... In some randomized clinical trials, the D1 dopaminergic activity of ibopamine led to an increased production of aqueous humour ...
https://en.wikipedia.org/wiki/Ibopamine
Posner-Schlossman syndromePosner-Schlossman syndrome
IOP and aqueous humor outflow return to normal in the remission periods. Exact etiology of PSS is unknown. Since it was first ... aqueous cells and flare may also be noted. Blurring of vision, eye pain and discomfort are the main symptoms. Colored halos may ...
https://en.wikipedia.org/wiki/Posner–Schlossman_syndrome
GlaucomaGlaucoma
... whose original function is to absorb the aqueous humor. Loss of aqueous humor absorption leads to increased resistance and thus ... Aqueous humor flows from the ciliary processes into the posterior chamber, bounded posteriorly by the lens and the zonules of ... This accumulation of aqueous humor causes an acute increase in pressure and pain. Degeneration of axons of the retinal ganglion ... The mechanism of open-angle glaucoma is believed to be the slow exit of aqueous humor through the trabecular meshwork, while in ...
https://en.wikipedia.org/wiki/Glaucoma
Iridocorneal endothelial syndromeIridocorneal endothelial syndrome
Groh, M. J.; Seitz, B.; Schumacher, S.; Naumann, G. O. (1999). "Detection of herpes simplex virus in aqueous humor in ...
https://en.wikipedia.org/wiki/Iridocorneal_endothelial_syndrome
TrabectomeTrabectome
Aqueous Humor Formation/Outflow] + Episcleral Venous Pressure. This equation states that free-flowing aqueous humor should ... aqueous humor can pass more freely into collector channels and aqueous veins. The Goldmann equation states that Intraocular ... The Trabecular meshwork is a major site of resistance to aqueous humor outflow. As angle surgeries such as Trabectome follow ... 2016) Aqueous outflow regulation: Optical coherence tomography implicates pressure-dependent tissue motion. Exp Eye Res. https ...
https://en.wikipedia.org/wiki/Trabectome
Ciliary bodyCiliary body
... which produces the aqueous humor. The aqueous humor is produced in the non-pigmented portion of the ciliary body. The ciliary ... and these secrete aqueous humor into the posterior chamber. The aqueous humor then flows through the pupil into the anterior ... Eighty percent of aqueous humor production is carried out through active secretion mechanisms (the Na+K+ATPase enzyme creating ... Because the ciliary body produces aqueous humor, it is the main target of many medications against glaucoma. Its inhibition ...
https://en.wikipedia.org/wiki/Ciliary_body
Pseudoexfoliation syndromePseudoexfoliation syndrome
The buildup of protein clumps can block normal drainage of the eye fluid called the aqueous humor and can cause, in turn, a ... The eye produces a clear fluid called the aqueous humor which subsequently drains such that there is a constant level of safe ... and improve the outflows of the aqueous humor. These can be done as an outpatient procedure and take less than twenty minutes. ... and removes a tiny area of the trabecular meshwork which enables the aqueous humor to discharge. This lowers the internal ...
https://en.wikipedia.org/wiki/Pseudoexfoliation_syndrome
RipasudilRipasudil
... on aqueous humor dynamics in rabbits". Current Eye Research. 39 (8): 813-22. doi:10.3109/02713683.2013.874444. PMID 24502505. ... drug that reduces IOP by stimulating the movement of aqueous humour from the ciliary body away from the eye. It is a selective ...
https://en.wikipedia.org/wiki/Ripasudil
Ghost cell glaucomaGhost cell glaucoma
Myriad small cells may be seen in the aqueous humor during slit lamp examination. Intraocular pressure rises up to 30 to 70 mm ... If IOP is not so high, medical therapy with aqueous suppressants is preferred. Surgery is advised if the intraocular pressure ...
https://en.wikipedia.org/wiki/Ghost_cell_glaucoma
Transforming growth factor betaTransforming growth factor beta
"Active transforming growth factor-beta2 is increased in the aqueous humor of keratoconus patients". Molecular Vision. 13: 1198- ...
https://en.wikipedia.org/wiki/Transforming_growth_factor_beta
Rapid eye movement sleepRapid eye movement sleep
... enables the aqueous humor to circulate. When the organism is sleeping, REM provides the much needed stir to aqueous humor. This ... he calculated that if aqueous humor was stagnant, oxygen from the iris had to reach the cornea by diffusion through aqueous ... and that aqueous humor, the liquid between cornea and iris, was stagnant if not stirred. Among the supportive evidence, ... humor, which was not sufficient. According to the theory, when the organism is awake, eye movement (or cool environmental ...
https://en.wikipedia.org/wiki/Rapid_eye_movement_sleep
TrabeculectomyTrabeculectomy
It is the most common glaucoma surgery performed and allows drainage of aqueous humor from within the eye to underneath the ... Various adjunctive devices have been used with trabeculectomy, to maintain drainage of aqueous humor and to maintain the ... Intraocular pressure may be lowered by allowing drainage of aqueous humor from within the eye to the following routes: (1) ... Glaucoma medications are usually discontinued to improve aqueous humor flow to the bleb. Topical medications consist typically ...
https://en.wikipedia.org/wiki/Trabeculectomy
Aqueous humourAqueous humour
... may be involved in production of aqueous humour. Aqueous humor is continually produced by the ciliary processes and this rate ... From there, the aqueous humor exits the eye through the trabecular meshwork into Schlemm's canal (a channel at the limbus, i.e ... Small variations in the production or outflow of aqueous humor will have a large influence on the intraocular pressure. The ... Veselovský J, Oláh Z, Veselá A, Gressnerová S (2001). "[The pH reaction in aqueous humor to antiglaucoma agents of various ...
https://en.wikipedia.org/wiki/Aqueous_humour
Bullous keratopathyBullous keratopathy
In a healthy cornea, endothelial cells keeps the tissue from excess fluid absorption, pumping it back into the aqueous humor. ...
https://en.wikipedia.org/wiki/Bullous_keratopathy
OnchocerciasisOnchocerciasis
... which were microfilariae moving freely in the aqueous humor of the anterior chamber of the eye. Blacklock and Strong had ...
https://en.wikipedia.org/wiki/Onchocerciasis
Topical prednisoloneTopical prednisolone
Endophthalmitis, which is an infection of the eye involving the aqueous humor, Graves' Ophthalmopathy, Herpes Zoster ocular ...
https://en.wikipedia.org/wiki/Topical_prednisolone
CA11CA11
... and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue ...
https://en.wikipedia.org/wiki/CA11
Wait Long by the River and the Bodies of Your Enemies Will Float ByWait Long by the River and the Bodies of Your Enemies Will Float By
... "humor and pathos, nihilism and the hope for redemption fight to the death inside Liddiard's voice as his mates [...] carry him ... aqueous world in sprawling, dense garage-blues epics". A similar point was made by Mark Abraham of Cokemachineglow, who ...
https://en.wikipedia.org/wiki/Wait_Long_by_the_River_and_the_Bodies_of_Your_Enemies_Will_Float_By
NeovascularizationNeovascularization
These blood vessels grow in abnormal ways and can invade into the vitreous humor, where they can hemorrhage or cause retinal ... bulk blocks the constant outflow of aqueous humour from inside the eye. Cardiovascular disease is the leading cause of death in ...
https://en.wikipedia.org/wiki/Neovascularization
List of Indian inventions and discoveriesList of Indian inventions and discoveries
SCS involves an exothermic redox chemical reaction between an oxidizer like metal nitrate and a fuel in an aqueous medium. ... ISBN 978-1-869928-43-8. Scharf, Hartmut (1999). "The Doctrine of the Three Humors in Traditional Indian Medicine and the ...
https://en.wikipedia.org/wiki/List_of_Indian_inventions_and_discoveries
Western African Ebola virus epidemicWestern African Ebola virus epidemic
His eye condition worsened and a specimen of aqueous humor obtained from his eye tested positive for Ebola. The authors of the ...
https://en.wikipedia.org/wiki/Western_African_Ebola_virus_epidemic
Index of anatomy articlesIndex of anatomy articles
... aorta aortic body aponeurosis apophysis appendage appendicular skeleton appendix aprosody aqueductal stenosis aqueous humor ... visceromotor nuclei viscus Visible Human Project visual cortex visual fields visual radiation vitreous body vitreous humor ...
https://en.wikipedia.org/wiki/Index_of_anatomy_articles
Injection (medicine)Injection (medicine)
Medications may also be administered by injecting them directly into the vitreous humor of the eye. This is termed an ... Depot injections are usually either oil-based or an aqueous suspension. Depot injections may be available as certain salt forms ... An intravitreal injection is performed by injecting a medication through the pupil into the vitreous humor core of the eye ...
https://en.wikipedia.org/wiki/Injection_(medicine)
FaturanandaFaturananda
I made up my mind then and there not to ever include romance in my humor and satire. I have followed this principle ever since ... Alonzo Simpson McDaniel (1990). The Absorption of Hydrocarbon Gases by Non-aqueous Liquids. University of Wisconsin--Madison. ... After seeing the same situation in all these published stories, I said - can't there be any humor without these college boys ...
https://en.wikipedia.org/wiki/Faturananda
PSMD1PSMD1
"Increased 26S proteasome non-ATPase regulatory subunit 1 in the aqueous humor of patients with age-related macular degeneration ...
https://en.wikipedia.org/wiki/PSMD1
RheologyRheology
The ocular Vitreous humor is subject to rheologic observations, particularly during studies of age-related vitreous ... Thickening agents, or thickeners, are substances which, when added to an aqueous mixture, increase its viscosity without ...
https://en.wikipedia.org/wiki/Rheology
SantoninSantonin
... it is owing to its direct action upon the aqueous humor, where it is carried by absorption, that objects present this color. ...
https://en.wikipedia.org/wiki/Santonin
PhysostigminePhysostigmine
... also increases outflow of the aqueous humor in the eye, making it useful in the treatment of glaucoma. An ...
https://en.wikipedia.org/wiki/Physostigmine
Canine glaucomaCanine glaucoma
This is achieved by reducing aqueous humor production, or by improving drainage of aqueous humor from the eye. Laser surgery is ... Secondary glaucomas occur when other eye diseases alter the flow of aqueous humor either into or out of the eye. Veterinarians ... The ongoing scarring over the conjunctival dissipation segment of the shunt may become too thick for the aqueous humor to ... is inserted into the anterior chamber of the eye and the plate is implanted underneath the conjunctiva to allow flow of aqueous ...
https://en.wikipedia.org/wiki/Canine_glaucoma
Hypotony maculopathyHypotony maculopathy
Maculopathy occurs either due to increased outflow of aqueous humor through angle of anterior chamber or less commonly, due to ... Maculopathy occurs either due to increased outflow of aqueous humor through angle of anterior chamber or less commonly, due to ... Increased outflow or aqueous loss may occur following a glaucoma surgery, trauma, post-surgical wound leak from the eye, ... decreased aqueous humor secretion by ciliary body. Hypotony maculopathy is maculopathy due to ocular hypotony. Fundus ...
https://en.wikipedia.org/wiki/Hypotony_maculopathy
Frank Fremont-SmithFrank Fremont-Smith
Cerebrospinal Fluid and Aqueous Humor of Certain Elasmobranchs," with Mary Elizabeth Dailey. Biological Bulletin, vol. 62, no. ...
https://en.wikipedia.org/wiki/Frank_Fremont-Smith
Carbonic anhydrase 4Carbonic anhydrase 4
... and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue ...
https://en.wikipedia.org/wiki/Carbonic_anhydrase_4
DorzolamideDorzolamide
The H+ is then exchanged for sodium (Na+) ions, which facilitates the production of aqueous humor[citation needed]. By blocking ... which leads to a decrease in Na+ in the cell and prevents aqueous humor production[citation needed]. This drug, developed by ... It is a carbonic anhydrase inhibitor and works by decreasing the production of aqueous humour. Dorzolamide was approved for ...
https://en.wikipedia.org/wiki/Dorzolamide
Adenosine 5-tetraphosphateAdenosine 5'-tetraphosphate
ATPP is a constituent of aqueous humor in rabbits, where it was found to reduce the intraocular pressure. ATPP has been ...
https://en.wikipedia.org/wiki/Adenosine_5'-tetraphosphate
Douglas Argyll RobertsonDouglas Argyll Robertson
Creating a small hole in the sclera (anterior sclerotomy) to drain the aqueous humor, would, he reasoned, lower intraocular ...
https://en.wikipedia.org/wiki/Douglas_Argyll_Robertson
David M. MauriceDavid M. Maurice
He introduced fluorescein for the investigation of aqueous humor flow, now an important technique in ocular research. In 1968 ... aqueous humor dynamics, and other topics in the physiology of the eye. ...
https://en.wikipedia.org/wiki/David_M._Maurice
Aqueous Humor Dynamics and Hypertensive Uveitis - Full Text View - ClinicalTrials.govAqueous Humor Dynamics and Hypertensive Uveitis - Full Text View - ClinicalTrials.gov
Aqueous Humor Dynamics and Hypertensive Uveitis. The safety and scientific validity of this study is the responsibility of the ... Ft is the rate of aqueous humor formation, C is the tonographic facility of outflow, IOP is the intraocular pressure, Pv is the ... The aqueous turnover protocol will be used to calculate the aqueous flow rate. Duplicate or triplicate scans will be collected ... The aqueous turnover protocol will be used to calculate the aqueous flow rate. Duplicate or triplicate scans will be collected ...
https://www.clinicaltrials.gov/show/NCT02765308
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies | Nature...Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies | Nature...
... comprising the conventional aqueous humor outflow pathway of the eye. Recently, heterozygous loss of function variants in TEK ... Thomson, B.R., Liu, P., Onay, T. et al. Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets ... Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma ... None of these proteins have been linked to elevated IOP, although Tenascin-C expression is regulated by aqueous humor outflow41 ...
https://www.nature.com/articles/s41467-021-26346-0?error=cookies_not_supported&code=92916630-da01-481b-befb-28e0dceb8648
Aqueous Humor Liquid Biopsy Laboratory | Childrens Hospital Los AngelesAqueous Humor Liquid Biopsy Laboratory | Children's Hospital Los Angeles
A liquid biopsy laboratory focused on the development of a multi-omics platform using the aqueous humor for diagnosis and ... We are the first laboratory in the world to develop this pioneering approach to using the aqueous humor as a liquid biopsy for ... Aqueous Humor Liquid Biopsy Laboratory Retinoblastoma (RB) is the most common childhood eye cancer forming in one or both ... Berrys team demonstrated-for the first time-that the aqueous humor (AH), a clear fluid accessible from the front of the eye, ...
https://www.chla.org/aqueous-humor-liquid-biopsy-laboratory
Application of aqueous humor polymerase chain reaction for virus in Posner-Schlossman syndrome | Research SquareApplication of aqueous humor polymerase chain reaction for virus in Posner-Schlossman syndrome | Research Square
Background To study the effectiveness and safety of aqueous humor PCR viral detection in the diagnosis of PSS.Methods 20 ... has been widely used in the diagnosis of infectious etiology in aqueous humor [11]. In this study, aqueous humor PCR was used ... RNA extraction of aqueous humor was done by the use of TRI reagent (Sigma, St. Louis, USA). This step must be performed ... Viral detection of aqueous humor by PCR identified the etiology of PSS of 30% patients and it was found that this technique was ...
https://www.researchsquare.com/article/rs-27004/v1
A Metabolomic Profile of Aqueous Humor in a 24-Hour Period After Death: An Animal Model for Postmortem Interval (PMI)...A Metabolomic Profile of Aqueous Humor in a 24-Hour Period After Death: An Animal Model for Postmortem Interval (PMI)...
A Metabolomic Profile of Aqueous Humor in a 24-Hour Period After Death: An Animal Model for Postmortem Interval (PMI) ...
https://www.aafs.org/research/metabolomic-profile-aqueous-humor-24-hour-period-after-death-animal-model-postmortem
Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence...Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence...
... model of circumferential aqueous humor outflow (AHO) in a living human eye with an automated detection algorithm for Schlemms ... The purpose was to create a three-dimensional (3-D) model of circumferential aqueous humor outflow (AHO) in a living human eye ... Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence ...
https://escholarship.org/uc/item/60t365jn
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. | Scholars@DukeCellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. | [email protected]
Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. ... Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. Journal Article ... comprising the conventional aqueous humor outflow pathway of the eye. Recently, heterozygous loss of function variants in TEK ...
https://scholars.duke.edu/display/pub1499823
MeSH | Aqueous Humor (D001082)MeSH | Aqueous Humor (D001082)
Anatomy [A] » Sense Organs [A09] » Eye » Anterior Eye Segment » Anterior Chamber » Aqueous Humor ... Anatomy [A] » Fluids and Secretions [A12] » Body Fluids » Extracellular Fluid » Aqueous Humor ...
https://www.cdek.liu.edu/mesh/D001082/
ST001278 - POAG and Control Aqueous Humor IROA Metabolites from Veterans Affairs Patients - OmicsDI
Aqueous humor was collected from the surgical and control eyes at 1, 2, and 5 months postoperation. Aqueous humor samples ... Proteome analysis of human aqueous humor.. Project description:Human aqueous humor (hAH) provides nutrition and immunity within ... METHODS:Aqueous humor samples were collected from patients with or without dry AMD, who underwent cataract surgery. The aqueous ... Pseudoexfoliation Aqueous Humor Metabolites from Veterans Affairs Patients. Project description:We performed high-performance ...
https://www.omicsdi.org/dataset/metabolomics_workbench/ST001278
Angiogenin, FGF-α, and IL-36β have higher expression levels in aqueous humor of nAMD patients in comparison to cataract...Angiogenin, FGF-α, and IL-36β have higher expression levels in aqueous humor of nAMD patients in comparison to cataract...
Aqueous humor samples were collected before the first (baseline), second (1 month later), and third (2 months later) injections ... Three cytokines in aqueous humor, including angiogenin, interleukin-36β (IL-36β), and fibroblast growth factor-acidic (FGF-α) ... The present study aimed to investigate the aqueous humor cytokine expression profile in nAMD patients before and after ... The aqueous concentrations of 28 cytokines were measured using a multiplex bead assay. Central macular thickness (CMT) and ...
https://bmcophthalmol.biomedcentral.com/articles/10.1186/s12886-020-01684-7
Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury<...
Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury. In: Prostaglandins and Other Lipid ... Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury. Akira Tokumura, Satoshi Taira, ... Lysophospholipids and lysophospholipase D in rabbit aqueous humor following corneal injury. Prostaglandins and Other Lipid ... keywords = "Aqueous humor, Autotoxin, Corneal injury, Lysophosphatidic acid, Lysophosphatidylcholine, Lysophospholipase D",. ...
https://augusta.pure.elsevier.com/en/publications/lysophospholipids-and-lysophospholipase-d-in-rabbit-aqueous-humor
Guidance for Management of Survivors of Ebola Disease in U.S. Healthcare Settings | Evaluating Patients | Clinicians | Ebola...Guidance for Management of Survivors of Ebola Disease in U.S. Healthcare Settings | Evaluating Patients | Clinicians | Ebola...
Aqueous humor. 14 weeks after illness onset by RT-PCR16. 14 weeks after illness onset by virus isolation16. ...
http://www.cdc.gov/vhf/ebola/healthcare-us/evaluating-patients/guidance-for-management-of-survivors-ebola.html
The Dynamics of Aqueous Humor Outflow-A Major Review | touchOPHTHALMOLOGYThe Dynamics of Aqueous Humor Outflow-A Major Review | touchOPHTHALMOLOGY
The maintenance of IOP in a steady state is largely a function of aqueous humor (AH) dynamics. This is dependent on a delicate ... Some aspects of aqueous humor drainage, Eye, 1993;7:14-9. *Gabelt BT, Gottanka J, Lutjen-Drecoll E, et al., Aqueous humor ... The Dynamics of Aqueous Humor Outflow-A Major Review. Published Online: September 22nd 2014 US Ophthalmic Review, 2014;7(2):137 ... The Role of Lymphatics in Aqueous Humor Outflow. The anterior segment of the eye is drained by lymphatics. According to Singh, ...
https://www.touchophthalmology.com/glaucoma/journal-articles/the-dynamics-of-aqueous-humor-outflow-a-major-review/
LymeNet Flash: Has anyone had their aqueous humor sampled/tested?LymeNet Flash: Has anyone had their aqueous humor sampled/tested?
Topic: Has anyone had their aqueous humor sampled/tested? cjnelson LymeNet Contributor Member # 12928 posted 12-26-2008 06:06 ... LymeNet Flash » Questions and Discussion » Medical Questions » Has anyone had their aqueous humor sampled/tested? ... The aqueous humor is the fluid in the eye that is constantly being replenished. I am curious if anyone has ever had theirs ... You can google testing on aqueous humor and you will find that it is a viable testing option for viruses and bacteria.. ...
https://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/75756?
The effects of cannabidiol on aqueous humor outflow and trabecular mes by Alyssa S. Aebersold and Zhao-Hui Song"The effects of cannabidiol on aqueous humor outflow and trabecular mes" by Alyssa S. Aebersold and Zhao-Hui Song
The goal of this study was to measure the effect of non-psychotropic cannabidiol (CBD) on aqueous humor outflow through TM and ... Perfused porcine eye anterior segment explants were used to investigate the effects of CBD on aqueous humor outflow. Cultured ... In the anterior segment perfusion experiments, aqueous humor outflow was increased significantly within 1 h after adding 1 µM ... CBD can enhance aqueous humor outflow and modify TM cell signaling ...
https://ir.library.louisville.edu/faculty/848/
Glaucoma: Too Much Aqueous Humor Is Nothing To Laugh At - ENCORE Research GroupGlaucoma: Too Much Aqueous Humor Is Nothing To Laugh At - ENCORE Research Group
The fluid that fills this area is called the aqueous humor. The aqueous humor is critically important for cleaning and bringing ... Another key job the aqueous humor performs is maintaining eye pressure.. The pressure in the eye needs to be maintained within ... Aqueous humor continuously flows through the front of the eye at a very slow rate (like blood, but slower). When the flow rate ...
https://encoredocs.com/2022/05/01/glaucoma-too-much-aqueous-humor-is-nothing-to-laugh-at/
Michigan MedicineMichigan Medicine
Aqueous humor. The shape of the front part of the eye is maintained by a fluid called aqueous humor. Aqueous humor is made by ... Aqueous humor flows into the front of the eye through the pupil. Aqueous humor drains out of the eye... ...
https://www.uofmhealth.org/health-library/topic/all?page=26
Aqueous Humor - Production, Circulation & Drainage part 1/2 - Dr. Najeeb Lectures - Medical Lectures VideosAqueous Humor - Production, Circulation & Drainage part 1/2 - Dr. Najeeb Lectures - Medical Lectures Videos
... - If you found this ... Home All Medical Lectures Videos Aqueous Humor - Production, Circulation & Drainage part 1/2 - Dr. Najeeb... ... Aqueous Humor - Production, Circulation & Drainage part 1/2 - Dr. Najeeb Lectures - Medical Lectures Videos. By ... Aqueous Humor. Production, Circulation & Drainage part 1/2. Dr. Najeeb Lectures - Medical Lectures Videos. ...
https://arslanlibrary.com/aqueous-humor-production-circulation-drainage-part-1/
Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma...Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma...
Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma ... The main determinant of IOP is the equilibrium between production and drainage of aqueous humor, with compromised drainage ... Humor Acuoso/metabolismo Modelos Animales de Enfermedad Ojo/metabolismo Glaucoma/patología Presión Intraocular Malla Trabecular ...
https://pesquisa.bvsalud.org/perinatal/resource/es/mdl-32341164
AACR19: Genomic cfDNA analysis of aqueous humor in retinoblastoma (RB) predicts eye salvage - CSI-CANCERAACR19: Genomic cfDNA analysis of aqueous humor in retinoblastoma (RB) predicts eye salvage - CSI-CANCER
Jesse Berry in 2017, to explore the using of aqueous humor from retinoblastoma (RB) eyes as liquid biopsy for the disease. RB ... AACR19: Genomic cfDNA analysis of aqueous humor in retinoblastoma (RB) predicts eye salvage. Presenter: ... we demonstrated that tumor-derived cell-free DNA can be extracted from the aqueous humor (AH) of RB eyes, which is safe to ... gap by harnessing the power of next-generation sequencing to assay rare tumor-derived nucleic acid fragments in the aqueous ...
https://kuhn.usc.edu/aacr19-genomic-cfdna-analysis-of-aqueous-humor-in-retinoblastoma-rb-predicts-eye-salvage/
Neovascular Glaucoma Medication: Cycloplegic drugs, Steroidal anti-inflammatory, Alpha2-adrenergic agonists, Carbonic anhydrase...Neovascular Glaucoma Medication: Cycloplegic drugs, Steroidal anti-inflammatory, Alpha2-adrenergic agonists, Carbonic anhydrase...
The exact mechanism of ocular antihypertensive action is not established, but it appears to be a reduction of aqueous humor ... Exact mechanism of action unknown but believed to reduce IOP by increasing outflow of aqueous humor through trabecular meshwork ... Inhibits enzyme carbonic anhydrase, reducing rate of aqueous humor formation, which, in turn, reduces IOP. Used for adjunctive ... Increased level of vascular endothelial growth factor in aqueous humor of patients with neovascular glaucoma. Ophthalmology. ...
https://www.medscape.com/answers/1205736-198354/which-medications-in-the-drug-class-prostaglandins-are-used-in-the-treatment-of-neovascular-glaucoma
Eye anatomy | Hoya VisionEye anatomy | Hoya Vision
Aqueous humor. A clear fluid in the space between the iris and the cornea. This maintains eye pressure and gives the front of ... Vitreous humor. A jelly-like substance that fills the middle of your eye, giving it form and shape. ...
https://www.hoyavision.com/en-ca/what-i-need/for-spectacle-wearers/understanding-vision/eye-anatomy/
Buy Alphagan P Eye Drops Online: Discount Generic & Prescription Drugs
Reduce Ocular Pressure by Restricting the Inflow of Aqueous Humor The pressure that builds up in your eye is caused when the ... this is the structure that releases the aqueous humor in your eye. ... your blood vessels to narrow which restricts the amount of fluid that filters out from the blood vessels to form aqueous humor ...
https://www.northwestpharmacy.com/product/alphagan-p-eye-drops
Fuchs Heterochromic Iridocyclitis (Fuchs Heterochromic Uveitis) Treatment & Management: Medical Care, Surgical Care, Further...Fuchs Heterochromic Iridocyclitis (Fuchs Heterochromic Uveitis) Treatment & Management: Medical Care, Surgical Care, Further...
Aqueous humor interleukin-6 levels in uveitis. Invest Ophthalmol Vis Sci. 1990 May. 31(5):917-20. [QxMD MEDLINE Link]. ... Highly focused clonal composition of CD8(+) CD28(neg) T cells in aqueous humor of fuchs heterochromic cyclitis. Exp Eye Res. ... Quentin CD, Reiber H. Fuchs heterochromic cyclitis: rubella virus antibodies and genome in aqueous humor. Am J Ophthalmol. 2004 ... eliminate cells from the anterior chamber as part of the cells and flare is contributed by the breakdown of the blood-aqueous ...
https://emedicine.medscape.com/article/1208706-treatment
Novel Retinal Lesion in Ebola Survivors, Sierra Leone, 2016 - Volume 23, Number 7-July 2017 - Emerging Infectious Diseases...
... only 1 aqueous humor sample had been obtained in an EVD survivor (9), enabling the detection of viable EBOV in aqueous humor ... J.R. performed aqueous humor laboratory analysis. P.J.S. and N.A.V.B. drafted the manuscript. P.J.S. and M.G.S. drafted the ... P.J.S. and F.M. undertook aqueous humor collection. P.J.S., F.M., A.D.F., and P.K. were responsible for data collection and ... The aqueous humor of 2 EVD survivors with white cataract and no anterior chamber inflammation was negative for EBOV RNA on qRT- ...
https://wwwnc.cdc.gov/eid/article/23/7/16-1608_article
Issue: Molecular TherapyIssue: Molecular Therapy
TET-dependent GDF7 hypomethylation impairs aqueous humor outflow and serves as a potential therapeutic target in glaucoma. * ...
https://www.cell.com/molecular-therapy-family/molecular-therapy/issue?pii=S1525-0016
Time dependent effects of sympathetic denervation on aqueous humor dynamics and choroidal blood flow in rabbits<...
keywords = "Aqueous humor dynamics, Blood flow, Ganglionectomy, Intraocular pressure, Rabbit",. author = "Zhan, {Gui Lin} and ... Time dependent effects of sympathetic denervation on aqueous humor dynamics and choroidal blood flow in rabbits. In: Current ... Time dependent effects of sympathetic denervation on aqueous humor dynamics and choroidal blood flow in rabbits. Current Eye ... Time dependent effects of sympathetic denervation on aqueous humor dynamics and choroidal blood flow in rabbits. / Zhan, Gui ...
https://scholars.mssm.edu/en/publications/time-dependent-effects-of-sympathetic-denervation-on-aqueous-humo-2
The changes of aqueous humor vascular endothelial growth factor and pigment epithelium-derived factor levels before and after...The changes of aqueous humor vascular endothelial growth factor and pigment epithelium-derived factor levels before and after...
Angiogenic factor/aqueous humor; Angiostatic proteins/aqueous humor; Diabetic retinopathy; Neovascularization; Vascular ... The changes of aqueous humor vascular endothelial growth factor and pigment epithelium-derived factor levels before and after ... Free VEGF and PEDF levels in aqueous humor appear to be significantly decreased after intravitreal injection of ranibizumab, ... in aqueous humor of PDR eyes before and after intravitreal injection of ranibizumab. ...
https://cjeo-journal.org/the-changes-of-aqueous-humor-vascular-endothelial-growth-factor-and-pigment-epithelium-derived-factor-levels-before-and-after-intravitreal-injection-of-ranibizumab-in-proliferative-diabetic-retinopath/
DailyMed - FORTAZ- ceftazidime injection, powder, for solutionDailyMed - FORTAZ- ceftazidime injection, powder, for solution
GlaucomaCorneaBreakdown of the blood-aqueous barrierVitreous humorReducing aqueous humor productionTrabecular meshwork and uveoscleral routesRate of aqueous humorLevels in aqueous humorOutflow of aqueous humorAltered aqueous productionChange in aqueousDrainageEnzyme carbonic anhydraseFlowsDecreasesPathwaysLensDynamicsFlareTimololUveoscleral outflowEtiologySignificantlyDorzolamideFluorophotometryLiquid biopsyDrainsCornealFluid in the eyeTissueProductionCataract surgeryPersistenceConcentrationsClear fluidVEGFConventional pathwayInflammatoryAnterior segmentReducesPatientsSuppressionInjectionsParacentesisReductionFills
Glaucoma13
  • Primary congenital glaucoma (PCG) is a severe disease characterized by developmental defects in the trabecular meshwork (TM) and Schlemm's canal (SC), comprising the conventional aqueous humor outflow pathway of the eye. (nature.com)
  • Differentiation of soluble aqueous humor metabolites in primary open angle glaucoma and controls. (omicsdi.org)
  • We report an analysis of the aqueous humor (AH) metabolome of primary open angle glaucoma (POAG) in comparison to normal controls. (omicsdi.org)
  • An abnormality of this pathway contributes significantly to disordered aqueous humor dynamics and consequent rise in intraocular pressure seen in primary open angle glaucoma and ocular hypertension. (touchophthalmology.com)
  • Cell atlas of aqueous humor outflow pathways in eyes of humans and four model species provides insight into glaucoma pathogenesis. (bvsalud.org)
  • May reduce elevated and normal IOP, with or without glaucoma, by reducing production of aqueous humor. (medscape.com)
  • OBJECTIVE: To determine the additive effect on aqueous humor flow of short-term dorzolamide treatment in patients with glaucoma receiving long-term treatment with timolol. (arctichealth.org)
  • Caucasians may be less predisposed to developing glaucoma due to slower aqueous flow and faster uveoscleral outflow rates compared with their Asian (particularly Chinese) counterparts, a study in the British Journal of Ophthalmology reports. (reviewofoptometry.com)
  • Additionally, slower aqueous flow rates coupled with faster uveoscleral outflow rates may factor into Caucasians' lower IOP and overall risk of glaucoma, the investigators concluded. (reviewofoptometry.com)
  • Malignant glaucoma (also known as ciliary block glaucoma, aqueous misdirection, or vitreous block ) has been described as a ciliolenticular block induced by anterior movement of the lens-iris interface, poor vitreous fluid conductivity (increased resistance to fluid movement through the vitreous), and choroidal expansion. (aao.org)
  • IMSEAR at SEARO: Fibrinolytic activity in blood and aqueous humour in glaucoma. (who.int)
  • Due to the blockage of this grid-like structure, the fluid (aqueous humor) gathers, thus increasing the pressure on your cornea and resulting in glaucoma. (apollospectra.com)
  • Acetazolamide has been used principally in veterinary medicine for its diuretic action and itseffects on aqueous humor production in the treatment of glaucoma and metabolic alkalosis. (entirelypetspharmacy.com)
Cornea7
  • Behind the cornea is a watery fluid called the aqueous humor. (kidshealth.org)
  • The cornea and aqueous humor form an outer lens that refracts (bends) light on its way into the eye. (kidshealth.org)
  • Light that has been focused through the cornea and aqueous humor hits the lens, which then focuses it further, sending the light rays through the vitreous humor and onto the retina. (kidshealth.org)
  • The aqueous humor is located in the anterior chamber of the eye and is a clear fluid that provides nutrients to the cornea and lens. (aapc.com)
  • Anterior chamber The area directly behind the cornea and in front of the iris -- contains the aqueous humor. (skidmore.edu)
  • The most important structure to examine is the anterior chamber, which is bound by the cornea and the iris and is filled with aqueous humor. (medscape.com)
  • For the proper working of your eyes, a fluid called aqueous humor usually flows out of your eyes from a grid-like structure behind the cornea. (apollospectra.com)
Breakdown of the blood-aqueous barrier2
  • Unlike other uveitides, topical steroids should not be used to eliminate cells from the anterior chamber as part of the cells and flare is contributed by the breakdown of the blood-aqueous barrier and leakage of inflammatory infiltrate. (medscape.com)
  • They also may increase inflammation by enhancing breakdown of the blood-aqueous barrier. (medscape.com)
Vitreous humor2
  • The eye also contains vitreous humor and aqueous humor. (aapc.com)
  • The vitreous humor is in the back of the eye and is more gel-like. (aapc.com)
Reducing aqueous humor production2
  • Decrease IOP by reducing aqueous humor production. (medscape.com)
  • Nonselective beta-adrenergic blocking agent that lowers IOP by reducing aqueous humor production. (medscape.com)
Trabecular meshwork and uveoscleral routes1
  • Exact mechanism of action unknown but believed to reduce IOP by increasing outflow of aqueous humor through trabecular meshwork and uveoscleral routes. (medscape.com)
Rate of aqueous humor1
  • The total positive rate of aqueous humor viral detection was 30% (6/20) in case group ,and was found none in control group (0/20) ( P = 0.027). (researchsquare.com)
Levels in aqueous humor1
  • Free VEGF and PEDF levels in aqueous humor appear to be significantly decreased after intravitreal injection of ranibizumab, and ocular neovascularization disappears at same time, which avoids intraoperative bleeding during vitrectomy. (cjeo-journal.org)
Outflow of aqueous humor3
  • It may facilitate outflow of aqueous humor and decrease vascular permeability. (medscape.com)
  • Flurbiprofen facilitates outflow of aqueous humor by inhibiting prostaglandin synthesis, causing a subsequent decrease in vascular permeability. (medscape.com)
  • Decreases IOP by increasing outflow of aqueous humor. (medscape.com)
Altered aqueous production1
  • The investigators propose to undertake a cross-sectional observational study of patients with recurrent idiopathic acute anterior uveitis, to determine the relative contributions of altered aqueous production and drainage to the development of raised IOP in these patients. (clinicaltrials.gov)
Change in aqueous2
  • The reduction in IOP at 24 hours after SCGx was not due to any change in aqueous flow or uveoscleral outflow (current study) but rather to an increase in outflow facility (previous studies). (mssm.edu)
  • Primary outcome measure was change in aqueous humor flare 3 weeks after surgery compared with baseline. (springer.com)
Drainage4
  • IOP homeostasis is regulated by the rates of aqueous humor secretion from the ciliary body and drainage through outflow pathways in the iridocorneal angle. (nature.com)
  • Intraocular pressure (IOP) is regulated primarily through aqueous humor production by ciliary body and drainage through uveoscleral and trabecular meshwork (TM) tissues. (louisville.edu)
  • The main determinant of IOP is the equilibrium between production and drainage of aqueous humor , with compromised drainage generally viewed as the primary contributor to dangerous IOP elevations. (bvsalud.org)
  • Usually, fluid (aqueous humor) in the eye flows freely through the anterior chamber and exits through the drainage system (trabecular meshwork). (mayoclinic.org)
Enzyme carbonic anhydrase1
  • Reduces aqueous humor formation by inhibiting enzyme carbonic anhydrase, which results in decreased IOP. (medscape.com)
Flows2
  • Aqueous humor continuously flows through the front of the eye at a very slow rate (like blood, but slower). (encoredocs.com)
  • Aqueous humor flows into the front of the eye through the pupil. (uofmhealth.org)
Decreases3
  • This effect decreases aqueous humor secretion, reducing IOP. (medscape.com)
  • Both act by inhibition of carbonic anhydrase in the ciliary processes that decreases aqueous humor formation. (medscape.com)
  • Separation and disruption of the overlying ciliary epithelium decreases its production of aqueous humor with consequent ocular hypotension. (medscape.com)
Pathways2
  • Automated circumferential construction of first-order aqueous humor outflow pathways using spectral-domain optical coherence tomography. (escholarship.org)
  • The goal of this study was to measure the effect of non-psychotropic cannabidiol (CBD) on aqueous humor outflow through TM and assess the effect of CBD on the TM cell signaling pathways that are important for regulating outflow. (louisville.edu)
Lens2
  • The aqueous humor is critically important for cleaning and bringing nutrients to the lens. (encoredocs.com)
  • it produces aqueous humor, facilitates trabecular outflow, intervenes in alteration of the shape of the crystalline lens during accommodation, and secretes hyaluronic acid into the vitreous. (medscape.com)
Dynamics8
  • The investigators therefore propose a study to examine the contribution of altered aqueous dynamics to the development of raised IOP in uveitis. (clinicaltrials.gov)
  • This review shall describe the various pathophysiologic mechanisms involved in aqueous humor dynamics. (touchophthalmology.com)
  • The maintenance of IOP in a steady state is largely a function of aqueous humor (AH) dynamics. (touchophthalmology.com)
  • This study investigates the time-dependent effects of superior cervical ganglionectomy (SCGx) on aqueous humor dynamics and ocular blood flow in rabbits. (mssm.edu)
  • Study cited differences in ocular and aqueous humor dynamics as contributors. (reviewofoptometry.com)
  • Investigators evaluated the parameters of aqueous humor dynamics and ocular biometrics and compared the groups. (reviewofoptometry.com)
  • Differences in aqueous humor dynamics and biometrics between Caucasian and Chinese adults include larger anterior chamber volume, which may contribute to the wider angles reported in Caucasians, researchers noted. (reviewofoptometry.com)
  • Differences in ocular biometrics and aqueous humour dynamics between Chinese and Caucasian adults. (reviewofoptometry.com)
Flare1
  • In uveitis, however, an increase in the protein content of the aqueous causes an effect upon examination known as flare, which is similar to that produced by a moving projector beam in a dark smoky room. (medscape.com)
Timolol2
  • Additive effect of dorzolamide on aqueous humor flow in patients receiving long-term treatment with timolol. (arctichealth.org)
  • CONCLUSIONS: Dorzolamide, a carbonic anhydrase inhibitor, has additive effects as an ocular hypotensive agent with timolol, a beta-adrenergic antagonist, even though both drugs are suppressors of aqueous humor flow. (arctichealth.org)
Uveoscleral outflow2
  • Looking at race only, Caucasians had slower aqueous flow rate (−0.22µL/min), thinner corneas (−0.52µm), lower IOP (−2.11mm Hg,), higher anterior chamber volume (30.39µL) and faster uveoscleral outflow rate (0.63 µL/min). (reviewofoptometry.com)
  • Selective alpha2-receptor that reduces aqueous humor formation and possibly increases uveoscleral outflow. (medscape.com)
Etiology1
  • Recurrences up to 13 months after EVD discharge have been reported, but confirmation of Ebola etiology through aqueous humor analysis was not conducted ( 7 ). (cdc.gov)
Significantly3
  • Three cytokines in aqueous humor, including angiogenin, interleukin-36β (IL-36β), and fibroblast growth factor-acidic (FGF-α) were significantly higher in nAMD patients in comparison to cataract patients, both before and after two consecutive monthly ranibizumab injections. (biomedcentral.com)
  • In the anterior segment perfusion experiments, aqueous humor outflow was increased significantly within 1 h after adding 1 µM CBD and the effect was sustained over the 5 h of measurement. (louisville.edu)
  • Aqueous humor flow was not significantly altered by SCGx at any time. (mssm.edu)
Dorzolamide1
  • RESULTS: Dorzolamide reduced aqueous humor flow by 24% +/- 11% (mean +/- SD). (arctichealth.org)
Fluorophotometry2
  • Intraocular pressure (IOP) was measured by pneumatonometry, aqueous flow by fluorophotometry and outflow facility by tonography. (mssm.edu)
  • Aqueous flow was measured with fluorophotometry and intraocular pressure with tonometry. (arctichealth.org)
Liquid biopsy2
  • We are the first laboratory in the world to develop this pioneering approach to using the aqueous humor as a liquid biopsy for children with retinoblastoma. (chla.org)
  • As a postdoctoral research associate in USC Michaelson CSI center, I started collaborating with Dr. Jesse Berry in 2017, to explore the using of aqueous humor from retinoblastoma (RB) eyes as liquid biopsy for the disease. (usc.edu)
Drains1
Corneal1
  • We previously found that lysophosphatidic acid (LPA)-like activity eliciting Cl - currents in Xenopus oocytes is increased in rabbit aqueous humor (AH) following corneal freeze wounds. (elsevier.com)
Fluid in the eye2
  • The aqueous humor is the fluid in the eye that is constantly being replenished. (lymenet.org)
  • The ciliary body produces the fluid in the eye called aqueous humor. (medlineplus.gov)
Tissue1
  • The potential advantages for this angle surgery are the removal of the area of greatest resistance to aqueous outflow and tissue debris which may reduce the inflammatory stimuli and consequently potential scarring. (hindawi.com)
Production4
  • Reversibly inhibits carbonic anhydrase, reducing hydrogen ion secretion at renal tubule and increasing renal excretion of sodium, potassium bicarbonate, and water to decrease production of aqueous humor. (medscape.com)
  • The exact mechanism of ocular antihypertensive action is not established, but it appears to be a reduction of aqueous humor production. (medscape.com)
  • Lower IOP by decreasing the production of aqueous humor. (medscape.com)
  • Lower IOP by a combination of decreasing production of aqueous and increasing aqueous outflow. (medscape.com)
Cataract surgery2
  • Aqueous humor from 2 EVD survivors with cataract but no anterior chamber inflammation were PCR-negative for Zaire Ebola virus, permitting cataract surgery. (cdc.gov)
  • Because of the unknown prevalence and duration of EBOV persistence in aqueous humor, survivors' access to cataract surgery is still restricted. (cdc.gov)
Persistence1
  • The duration of EBOV ocular persistence remains unknown, although repeated aqueous humor testing in the same survivor was negative for EBOV by quantitative reverse transcription PCR (qRT-PCR) 1 year later ( 10 ). (cdc.gov)
Concentrations3
  • The aqueous concentrations of 28 cytokines were measured using a multiplex bead assay. (biomedcentral.com)
  • Compared with the nAMD patients' basal levels, two consecutive monthly ranibizumab injections effectively reduced the aqueous concentrations of VEGF-A and placental growth factor (PlGF), as well as the values of CMT, MRT-3 mm, and GLD. (biomedcentral.com)
  • Previous research has reported that in the aqueous humor of eyes with nAMD, many cytokines are found at higher concentrations than in the eyes of cataract patients. (biomedcentral.com)
Clear fluid1
  • In 2017, this paradigm changed when Dr. Berry's team demonstrated-for the first time-that the aqueous humor (AH), a clear fluid accessible from the front of the eye, contains DNA from the tumor and could be used for diagnosis and prognosis for saving the eye. (chla.org)
VEGF1
  • This study was to determine the levels of vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) in aqueous humor of PDR eyes before and after intravitreal injection of ranibizumab. (cjeo-journal.org)
Conventional pathway2
  • With aging, the latter becomes less active so that the conventional pathway remains the primary mechanism of aqueous humor outflow. (touchophthalmology.com)
  • 4 The outflow rate through this route tends to decrease with age so that the conventional pathway has to take up more function of aqueous outflow. (touchophthalmology.com)
Inflammatory1
  • Intraocular inflammatory condition of nAMD could be reflected by aqueous humor and vitreous fluid more directly and accurately than serum. (biomedcentral.com)
Anterior segment3
  • The purpose was to create a three-dimensional (3-D) model of circumferential aqueous humor outflow (AHO) in a living human eye with an automated detection algorithm for Schlemm's canal (SC) and first-order collector channels (CC) applied to spectral-domain optical coherence tomography (SD-OCT). Anterior segment SD-OCT scans from a subject were acquired circumferentially around the limbus. (escholarship.org)
  • The elucidation of the aqueous proteome will establish a foundation for protein function analysis and identification of differentially expressed markers associated with diseases of the anterior segment. (omicsdi.org)
  • Perfused porcine eye anterior segment explants were used to investigate the effects of CBD on aqueous humor outflow. (louisville.edu)
Reduces1
  • Selective alpha2-receptor that reduces aqueous humor formation. (medscape.com)
Patients6
  • The detection of virus in aqueous humor by PCR is effective and safe for diagnosis of PSS, and helpful for targeted treatment on virus-positive patients. (researchsquare.com)
  • We performed high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) Isotopic Ratio Outlier Analysis of aqueous humor samples from patients from patients with pseudoefoliation syndrome (PEX). (omicsdi.org)
  • Proteomic analysis of Exosomes derived from the Aqueous Humor of Myopia Patients. (omicsdi.org)
  • The present study aimed to investigate the aqueous humor cytokine expression profile in nAMD patients before and after ranibizumab treatments in comparison to cataract patients. (biomedcentral.com)
  • Studying aqueous cytokines in nAMD patients is feasible and necessary to understand the pathogenesis of nAMD, and could provide ideas to develop new antibody drugs. (biomedcentral.com)
  • Spirochetes have now been found in aqueous humor, cerebrospinal fluid, liver, and lymph nodes in several patients with late seronegative syphilis. (lymenet.org)
Suppression2
  • Medical treatment consists of cycloplegia and aqueous suppression, as well as hyperosmotic agents (eg, oral glycerin or intravenous mannitol). (aao.org)
  • In the cat model, haloperidol increased aqueous humor (AH) outflow initially, followed by a long-lasting suppression of AH formation. (jamanetwork.com)
Injections1
  • Aqueous humor samples were collected before the first (baseline), second (1 month later), and third (2 months later) injections. (biomedcentral.com)
Paracentesis1
  • Marked IOP elevation in the early postoperative period may be temporarily managed by applying gentle pressure on the posterior lip of a preexisting paracentesis incision to release a small amount of aqueous humor. (aao.org)
Reduction1
  • Topical and/or systemic pressure-lowering agents should also be administered, as IOP reduction after aqueous release is short-lived, with the IOP likely to rise again within 1-2 hours of decompression. (aao.org)
Fills1
  • The fluid that fills this area is called the aqueous humor. (encoredocs.com)
Aqueous Humor Dynamics and Hypertensive Uveitis - Full Text View - ClinicalTrials.gov
Aqueous Humor Dynamics and Hypertensive Uveitis - Full Text View - ClinicalTrials.gov (clinicaltrials.gov)
Neovascular Glaucoma Medication: Cycloplegic drugs, Steroidal anti-inflammatory, Alpha2-adrenergic agonists, Carbonic anhydrase...
Neovascular Glaucoma Medication: Cycloplegic drugs, Steroidal anti-inflammatory, Alpha2-adrenergic agonists, Carbonic anhydrase... (medscape.com)
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Iris Melanoma: Overview, Pathophysiology and Etiology, Epidemiology (medscape.com)
Iritis and Uveitis Clinical Presentation: History, Physical, Causes
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Iritis and Uveitis: Practice Essentials, Background, Pathophysiology
Iritis and Uveitis: Practice Essentials, Background, Pathophysiology (medscape.com)
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Primary Open-Angle Glaucoma (POAG) Clinical Presentation: History, Physical, Causes (medscape.com)
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Ciliary body: MedlinePlus Medical Encyclopedia
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DailyMed - FORTAZ- ceftazidime injection, powder, for solution
DailyMed - FORTAZ- ceftazidime injection, powder, for solution (dailymed.nlm.nih.gov)
Perilymphatic Fistula Treatment & Management: Medical Therapy, Preoperative Details, Intraoperative Details
Perilymphatic Fistula Treatment & Management: Medical Therapy, Preoperative Details, Intraoperative Details (emedicine.medscape.com)
Use of Ebola Vaccine: Recommendations of the Advisory Committee on Immunization Practices, United States, 2020 | MMWR
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Retinoblastoma Workup: Laboratory Studies, Imaging Studies, Other Tests (emedicine.medscape.com)
(emedicine.medscape.com)