The clear, watery fluid which fills the anterior and posterior chambers of the eye. It has a refractive index lower than the crystalline lens, which it surrounds, and is involved in the metabolism of the cornea and the crystalline lens. (Cline et al., Dictionary of Visual Science, 4th ed, p319)
The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.
A system of artificial or natural drains, generally used for the disposal of liquid wastes.
Exclusive legal rights or privileges applied to inventions, plants, etc.
The space in the eye, filled with aqueous humor, bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and that part of the crystalline lens which presents through the pupil. (Cline et al., Dictionary of Visual Science, 4th ed, p109)
Hyperextension injury to the neck, often the result of being struck from behind by a fast-moving vehicle, in an automobile accident. (From Segen, The Dictionary of Modern Medicine, 1992)
Plastic tubes used for drainage of air or fluid from the pleural space. Their surgical insertion is called tube thoracostomy.
Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.
Enzymes that catalyze the first step leading to the oxidation of succinic acid by the reversible formation of succinyl-CoA from succinate and CoA with the concomitant cleavage of ATP to ADP (EC 6.2.1.5) or GTP to GDP (EC 6.2.1.4) and orthophosphate. Itaconate can act instead of succinate and ITP instead of GTP.EC 6.2.1.-.
A surgical specialty concerned with the structure and function of the eye and the medical and surgical treatment of its defects and diseases.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.
A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
Drugs that block nerve conduction when applied locally to nerve tissue in appropriate concentrations. They act on any part of the nervous system and on every type of nerve fiber. In contact with a nerve trunk, these anesthetics can cause both sensory and motor paralysis in the innervated area. Their action is completely reversible. (From Gilman AG, et. al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed) Nearly all local anesthetics act by reducing the tendency of voltage-dependent sodium channels to activate.
The removal of a cataractous CRYSTALLINE LENS from the eye.
Introduction of substances into the body using a needle and syringe.
The administration of substances into the eye with a hypodermic syringe.
Infection caused by the protozoan parasite TOXOPLASMA in which there is extensive connective tissue proliferation, the retina surrounding the lesions remains normal, and the ocular media remain clear. Chorioretinitis may be associated with all forms of toxoplasmosis, but is usually a late sequel of congenital toxoplasmosis. The severe ocular lesions in infants may lead to blindness.
A genus of protozoa parasitic to birds and mammals. T. gondii is one of the most common infectious pathogenic animal parasites of man.
The acquired form of infection by Toxoplasma gondii in animals and man.
Inflammation of the choroid in which the sensory retina becomes edematous and opaque. The inflammatory cells and exudate may burst through the sensory retina to cloud the vitreous body.
Prenatal protozoal infection with TOXOPLASMA gondii which is associated with injury to the developing fetal nervous system. The severity of this condition is related to the stage of pregnancy during which the infection occurs; first trimester infections are associated with a greater degree of neurologic dysfunction. Clinical features include HYDROCEPHALUS; MICROCEPHALY; deafness; cerebral calcifications; SEIZURES; and psychomotor retardation. Signs of a systemic infection may also be present at birth, including fever, rash, and hepatosplenomegaly. (From Adams et al., Principles of Neurology, 6th ed, p735)
Acquired infection of non-human animals by organisms of the genus TOXOPLASMA.
Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
Mechanical food dispensing machines.
The branch of pharmacology that deals directly with the effectiveness and safety of drugs in humans.
The study of the origin, nature, properties, and actions of drugs and their effects on living organisms.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.

Estimation of corneal endothelial pump function in long-term contact lens wearers. (1/1321)

PURPOSE: To study the effects of long-term contact lens wear on morphologic and physiologic properties of corneal endothelial cells. METHODS: The endothelial permeability to fluorescein and the rate of corneal deswelling from hypoxia-induced edema were measured in 20 long-term (mean, 17+/-9 years; range, 5-33 years) contact lens wearers and 20 age-matched control subjects. From these data, the relative endothelial pump rate in each subject was estimated, based on the pump-leak hypothesis of corneal hydration control. Corneal autofluorescence and the aqueous humor flow rate were determined by fluorescein fluorophotometry. Images of corneal endothelial cells were recorded by using specular microscopy, and morphologic indices (cell density, coefficient of variation of cell area, percentage of hexagonal cells, and skewness) were determined. RESULTS: No statistically significant differences were found between the contact lens and control groups in endothelial permeability, corneal deswelling, relative endothelial pump rate ([mean +/- SD] 1.07+/-0.33 relative pump units versus 1.01+/-0.25 relative pump units; contact lens versus control; P = 0.57), and endothelial cell density. Contact lens wearers had a significantly higher aqueous humor flow rate (3.57+/-1.03 microl/min versus 2.77+/-0.51 microl/min; P = 0.005), coefficient of variation of cell area (0.35+/-0.09 versus 0.28+/-0.04; P = 0.006), and corneal autofluorescence (3.1+/-0.6 ng/ml versus 2.3+/-0.3 ng/ml fluorescein equivalents; P < 0.001) than did non-contact lens wearers. CONCLUSIONS: Despite the known effects of long-term contact lens wear on corneal endothelial morphometry, no effect on endothelial function was found.  (+info)

Latrunculin-A increases outflow facility in the monkey. (2/1321)

PURPOSE: To determine the effect of Latrunculin (LAT)-A, a macrolide that binds to G-actin, which leads to the disassembly of actin filaments, on shape, junctions, and the cytoskeleton of cultured bovine aortic endothelial cells (BAECs) and on outflow facility in living monkeys. METHODS: Latrunculin-A dose-time-response relationships in BAECs were determined by immunofluorescence and phase contrast light microscopy, facility by two-level constant pressure anterior chamber perfusion. RESULTS: In BAECs, LAT-A caused dose- and incubation time- dependent destruction of actin bundles, cell separation, and cell loss. Cell-cell adhesions were more sensitive than focal contacts. Recovery was also dose- and time-dependent. In monkeys, exchange intracameral infusion and topical application of LAT-A induced dose- and time-dependent several-fold facility increases. The facility increase was completely reversed within several hours after drug removal. However, for at least 24 hours after a single topical LAT-A dose, perfusion with drug-free solution caused an accelerated increase in facility beyond that attributed to normal resistance washout. CONCLUSIONS: Pharmacological disorganization of the actin cytoskeleton in the trabecular meshwork by specific actin inhibitors like LAT-A may be a useful antiglaucoma strategy.  (+info)

Effect of staurosporine on outflow facility in monkeys. (3/1321)

PURPOSE: To determine the effect of the serine-threonine kinase inhibitor staurosporine on outflow facility in living monkeys. METHODS: Total outflow facility was determined by two-level constant pressure perfusion of the anterior chamber bilaterally before and after intracameral infusion of staurosporine or vehicle in opposite eyes. RESULTS: Intracameral staurosporine dose-dependently doubled outflow facility, with 0.1 microM, 1 microM, and 10 microM being subthreshold, effective, and maximal doses, respectively. At 50 microM, intracameral staurosporine was less effective than 10 microM on facility and induced corneal toxicity. CONCLUSIONS: The broad-spectrum protein kinase inhibitor staurosporine increases outflow facility in living monkeys, perhaps by affecting the trabecular meshwork cytoskeleton.  (+info)

Cytomegalovirus (CMV) retinitis activity is accurately reflected by the presence and level of CMV DNA in aqueous humor and vitreous. (4/1321)

To evaluate the potential of ocular and systemic specimens to provide markers of active cytomegalovirus (CMV) retinitis, we examined the relationship between virologic and clinical aspects of CMV infections in AIDS patients with CMV retinitis. CMV polymerase chain reaction (PCR) analysis of 74 aqueous humor and vitreous specimens indicated that ocular specimens can provide accurate markers to differentiate active and inactive CMV retinitis (aqueous or vitreous PCR, P<.001). Moreover, these markers were superior to extraocular measures, including plasma PCR (P=.08) and blood and urine CMV cultures (P=.05). A direct correlation was identified between the quantity of CMV DNA in aqueous humor or vitreous specimens and the corresponding surface area of active CMV retinitis (r2=.69 and.44, respectively). Thus, qualitative and quantitative PCR-based analyses of aqueous humor can provide valuable markers of CMV retinitis activity. Such assays could provide rapid and reliable tools to assist in management of patients with CMV retinitis in whom the view of the retina is obscured.  (+info)

High frequency of persistent hyperplastic primary vitreous and cataracts in p53-deficient mice. (5/1321)

In order to investigate whether the p53 gene product plays a role in normal eye development, age matched p53-deficient mice and wild-type controls were sacrificed from day 2 to day 21 after birth. Eyes were paraffin-embedded and sectioned. Serial sections were taken at the level of the tunica vasculosa lentis and the hyaloid artery. The terminal dUTP nick-end labelling technique (TUNEL) was used to detect the number of cells displaying DNA fragmentation within these structures. Eyes were also prepared for scanning electron microscopy and resin embedded for semi-thin sections. Adult wild-type mice and p53-deficient mice were examined ophthalmoscopically in vivo. Ophthalmoscopical examination of mice completely deficient in p53 revealed them to be normal except for the persistence of the hyaloid vasculature, a structure that normally regresses during eye development. In adult animals there was also a high frequency of cataracts. Using morphological assessment and TUNEL we could show that in normal mice, regression of the primary vitreous, which includes the hyaloid artery, the vasa hyaloidea propria as well as the tunica vasculosa lentis, occurs via apoptotic cell death within 5 - 6 weeks after birth. The number of TUNEL-positive cells within these structures was significantly reduced in the p53-deficient mice in which parts of the hyaloid vasculature persisted and developed into a fibro-vascular retrolental plaque analogous to persistent hyperplastic primary vitreous (PHPV) described in humans. As in humans, PHPV in mice resulted in the development of cataracts. We have identified a role for p53-dependent apoptosis in the regression of the hyaloid vasculature and tunica vasculosa lentis. Our results provide further evidence for the importance of p53 in normal development and provide the first detailed evidence of its role in postnatal development in remodelling the developing eye.  (+info)

Electrical parameters of the isolated cornea of the dogfish, Squalus acanthias. (6/1321)

The electrical potential difference and electrical resistance of the nonswelling cornea of the dogfish, Squalus acanthias, were examined. It was found that routine procedures used in the procurement of fish invariably produce damage to the corneal epithelium which affects electrical measurements and possibly composition of the aqueous humor. We found no electrical evidence of ionic pumps in the corneal epithelium of this elasmobranch. The electrical resistance of corneas with apparently well-preserved epithelium was 300omega-cm.2 (compared to 30omega-cm.2 in corneas with damaged epithelium).  (+info)

Enthacrynic and acid effects on inner wall pores in living monkeys. (7/1321)

PURPOSE: The influence of the inner wall of Schlemm's canal on aqueous outflow facility remains poorly understood. We examined the relationship between inner wall pore characteristics and outflow facility in living primate eyes in which facility had been pharmacologically increased by ethacrynic acid (ECA) infusion and in contralateral control eyes. METHODS: Outflow facility (two-level constant pressure perfusion) was measured in eight pairs of living monkey eyes before and after administration of a bolus dose of either 0.125 mM ECA or vehicle. After exsanguination, eyes were fixed in situ under constant-pressure conditions (mean fixation pressure approximately 19 mm Hg). The density and diameter of inner wall pores and the number and area of platelet aggregates on the inner wall of Schlemm's canal were measured by scanning electron microscopy. RESULTS: In ECA-treated eyes, outflow facility increased 63% (P < 0.0001), intracellular pore density decreased 46% (P = 0.0094), intracellular pore size increased 27% (P = 0.049), platelet aggregate density increased 158% (P < 0.0001), and area covered by platelets increased 210% (P = 0.012) relative to contralateral controls. Although the average density and size of intercellular pores were essentially unaffected by ECA, an increased density of large (> or = 1.90 microm) intercellular pores was seen in ECA-treated eyes. The density of intracellular pores increased with the duration of fixative perfusion. Other than a weak negative correlation between outflow facility and intracellular pore density in ECA-treated eyes (P = 0.052), facility was not correlated with inner wall pore features. CONCLUSIONS: Our data are most consistent with a scenario in which ECA promotes formation of large intercellular pores in the inner wall of Schlemm's canal, which are then masked by platelet aggregates. Masking of intercellular pores, combined with fixation-induced alteration of inner wall pore density, greatly complicates attempts to relate facility to inner wall structure and suggests that in vivo pore density is smaller than in fixed tissue. Additionally, facility-influencing effects of ECA on the juxtacanalicular tissue cannot be excluded.  (+info)

Effect of aqueous humor on apoptosis of inflammatory cell types. (8/1321)

PURPOSE: To determine whether aqueous humor promotes cell death in cells involved in inflammatory responses. METHODS: Multiple immune cell types, most characteristically involved in inflammatory responses, were incubated for 24, 48, and 72 hours in the presence or absence of 50% aqueous humor. Promotion of cell death was assayed by staining for an early indicator of apoptosis. The percentage of cells undergoing apoptosis was measured by flow cytometry. To identify partially the apoptosis inducing factor, aqueous humor was pretreated with proteinase K to degrade protein. In other experiments, aqueous humor was fractionated by centrifugation on filters capable of separating molecules above and below 10 kDa or 30 kDa kilodaltons in size. RESULTS: Rabbit aqueous humor promoted apoptosis in a wide variety of immune cells, including lymphokine-activated natural killer cells, resting T cells, an activated T-cell line, RAW 264.7 and J774A0.1 monocyte-macrophage cell lines, and neutrophils. As previously shown, aqueous humor did not promote apoptosis of murine corneal endothelial cells. Apoptosis was also not induced in human corneal endothelium, mouse corneal epithelium, or iris/ciliary body cell lines. Instead, aqueous humor partially protected these ocular tissues from starvation-induced cell death. Pretreatment with proteinase K inhibited the apoptosis-inducing activity. Moreover, the apoptosis-inducing activity segregated with the aqueous humor fraction containing molecules less than than 10 kDa in size. CONCLUSIONS: These data show that aqueous humor contains a factor or factors that promote death of cells that participate in inflammatory processes. By contrast, ocular tissues, such as the corneal endothelium and iris/ciliary body, are impervious to aqueous humor-induced cell death. The aqueous humor- borne factor(s) may contribute to the immune privilege of the anterior chamber by purging potential inflammatory cells.  (+info)

Purine nucleotide degradation products have been determined by HPLC in aqueous humor obtained during cataract surgery and from plasma of 22 patients (12 women). Uric acid, cytosine, guanosine monophosphate, uracyl, guanine, adenosine, adenosine monophosphate, thymine, adenine, inosine, cyclic guanosine monophosphate, hypoxanthine and xanthine were evaluated. Uric acid and the last two were the only compounds detectable in measurable amounts in aqueous humor and in plasma of all patients. Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were lower than those of xanthine and than plasma oxypurine levels. In 8 patients, treated with allopurinol, oxypurinol concentrations in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor barrier.. ...
Synonyms for aqueous humor in Free Thesaurus. Antonyms for aqueous humor. 1 synonym for aqueous humor: aqueous humour. What are synonyms for aqueous humor?
Purpose: : Recent studies in our laboratory have demonstrated that nitric oxide plays a role in morphine-induced reduction of intraocular pressure and pupil diameter in New Zealand white (NZW) rabbits. The goal of the present study was to determine the effect of morphine on nitric oxide levels in the aqueous humor of NZW rabbits. Methods: : Normal, dark-adapted (reverse light cycle, 12/12 hr dark/light) NZW rabbit eyes were treated topically and bilaterally as follows: 1) morphine (100 µg) for 5 or 30 minutes; 2) 30 minute pretreatment with naloxone (100 µg; a nonselective opioid receptor antagonist) or L-NAME (0.5 %; a nitric oxide synthase inhibitor), followed by treatment with morphine for 5 or 30 minutes. Aqueous humor samples were obtained by paracenthesis and immediately assayed for nitric oxide (nitrites + nitrates) using a nitric oxide quantitation kit. Results: : The levels of NO in aqueous humor of rabbits treated with morphine for 5 minutes, increased from 34.22 ± 2.22 µM ...
Although the resistance to outflow, postoperatively, is probably dependent on the TDM,7 proponents of viscocanalostomy4 advocate tightly suturing the superficial flap in an attempt to avoid subconjunctival filtration. Whether tightly or loosely suturing the flap affects the overall outflow facility changes after NPGS has, to our knowledge, not been investigated before.. We report an in vitro mean preoperative outflow facility in isolated porcine eyes, in line with previously published work.11 The mean (SD) outflow facility after NPGS (1.584 (0.217) μl/min/mm Hg) is relatively lower than previously reported mean outflow facility after trabeculectomy11 (2.957 (0.602) μl/min/mm Hg), which possibly accounts for the gradual decrease in IOP after NPGS, as opposed to the sudden drop in pressure after penetration as in the case of trabeculectomy.. According to McEwen12 a single patent hole of 12 μm is by itself sufficiently large to provide a normal facility of outflow. Based on this we would have ...
Purpose: To look at the influence of aqueous humour protein content and viscosity, which may increase in anterior chamber inflammation, on equilibrium pressure under the scleral flap in trabeculectomies. The influence of suture numbers and scleral flap shapes was also investigated. Methods: Normal and uveitic aqueous humour were represented by plain BSS, BSS containing 300 mg/ 100 ml of albumin and BSS containing 3000 mg/ 100 ml of albumin. Porcine corneoscleral rims were mounted on a Barron artificial anterior chamber and chamber pressure was measured using a pressure transducer. 4 mm x 4 mm partial thickness scleral flaps and 0.75 mm diameter sclerostomies were created, followed by re-suturing of the flap with either 2 or 4 sutures, as in a trabeculectomy. Equilibrium pressure in the chamber was noted. The square scleral flaps were also compared with 4 mm x 3 mm rectangular and 4 mm x 4 mm triangular flaps. In all cases, n = 8. Statistical analysis involved the unpaired t-test and one-way ...
PURPOSE: To obtain aqueous humor and tear fluid samples during cataract surgery of the hepatitis C virus (HCV)-antibody-positive patients in order to analyze them for HCV RNA and compare these measurements with serum HCV RNA levels.. METHODS: Twenty-nine anti-HCV-positive patients were included this study. HCV RNA viral load levels were determined by commercial real-time polymerase chain reaction system. Antibodies to HCV were screened with the enzyme-linked immunosorbent assay (ELISA) using anti-HCV test kit.. RESULTS: Log10 HCV RNA levels were found to be 6.00 ± 1.06 IU/mL in serum, 2.76 ± 0.36 IU/mL in the aqueous humor, and 1.91 ± 0.93 IU/mL in tear fluid. No correlation was detected between samples for HCV RNA positivity (p = .390, κ = .102). We have observed that, viral RNA was detected in the aqueous humor, while not in serum in one case, whereas viral RNA was detected in tear fluid but not in serum in another case.. CONCLUSIONS: Although viral load detected in aqueous humor and tear ...
GALLARDO, C.; PAREDES, E. e PEREZ, J.. Histopathological study of canine liver and kidney and their relationship with blood and postmortem aqueous humour samples concentrations of urea, creatinine, proteins and enzymes activities (ALT and SAP). Arch. med. vet. [online]. 2003, vol.35, n.1, pp.61-74. ISSN 0301-732X. http://dx.doi.org/10.4067/S0301-732X2003000100006.. The goal of this study was to characterize histopathological lesions of the liver and kidney of canines, and their relationship with blood and postmortem samples of aqueous humor concentrations of urea, creatinine, proteins and ALT and SAP plasmatic activity. Thirty one animals were used in this study. They did not have clinical history of hepatic or renal diseases. Plasma samples were obtained before euthanasia. A sample of aqueous humor was obtained from the right eye of each dog just after euthanasia and a similar sample was obtained 24 hours later from the left eye. Urea, creatinine and protein concentrations and plasmatic ...
Experimental Eye Research, Vol: 127, Pages: 224-235, ISSN: 1096-0007 The bulk of aqueous humor passing through the conventional outflow pathway must cross the inner wall endothelium of Schlemms canal (SC), likely through micron-sized transendothelial pores. SC pore density is reduced in glaucoma, possibly contributing to obstructed aqueous humor outflow and elevated intraocular pressure (IOP). Little is known about the mechanisms of pore formation; however, pores are often observed near dome-like cellular outpouchings known as giant vacuoles (GVs) where significant biomechanical strain acts on SC cells. We hypothesize that biomechanical strain triggers pore formation in SC cells. To test this hypothesis, primary human SC cells were isolated from three non-glaucomatous donors (aged 34, 44 and 68), and seeded on collagen-coated elastic membranes held within a membrane stretching device. Membranes were then exposed to 0%, 10% or 20% equibiaxial strain, and the cells were aldehyde-fixed 5 min after ...
A pioneering dye-based technique that enables aqueous humour outflow to be studied has the potential to improve glaucoma angle-based procedures and surgery outcomes.
TY - JOUR. T1 - Impaired angiopoietin/Tie2 signaling compromises Schlemms canal integrity and induces glaucoma. AU - Kim, Jaeryung. AU - Park, Dae Young. AU - Bae, Hosung. AU - Park, Do Young. AU - Kim, Dongkyu. AU - Lee, Choong Kun. AU - Song, Sukhyun. AU - Chung, Tae Young. AU - Lim, Dong Hui. AU - Kubota, Yoshiaki. AU - Hong, Young Kwon. AU - He, Yulong. AU - Augustin, Hellmut G.. AU - Oliver, Guillermo. AU - Koh, Gou Young. PY - 2017/10/2. Y1 - 2017/10/2. N2 - Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also ...
Glaucoma is a leading cause of blindness, with an estimated world-wide prevalence of 3.5% in members of the population older than 40 years of age. Elevated intraocular pressure as the result of abnormal resistance to aqueous humor drainage is a major contributing, and the only preventable, factor in glaucoma development. Schlemms canal (SC), a lymphatic-like vessel encircling the anterior portion of the eye, plays a key role in promoting aqueous humor outflow and maintenance of normal intraocular pressure. The risk of developing glaucoma increases with age; therefore, understanding mechanisms of SC maintenance and how aging affects SC function are of special importance, both for prevention and novel treatment approaches to glaucoma. Using a compelling array of genetic models, Kim et al. report in this issue of the JCI that continuous angiopoietin/TIE2 signaling is required for maintaining SC identity and integrity during adulthood and show that its age-related changes can be rescued by a TIE2 ...
Expression levels of 87 proteins were found to be different between glaucomatous and control aqueous humor. Of the 87 proteins, 34 were significantly upregulated, whereas 53 proteins were downregulated in the aqueous humor from glaucoma patients compared to controls. Differentially expressed proteins were found to be involved in cholesterol-related, inflammatory, metabolic, antioxidant as well as proteolysis-related processes.. CONCLUSION ...
In the anterior part of our eye there are two cavities filled with a watery but nutritive fluid called aqueous humor. One cavity, called the anterior chamber, lies just behind the cornea and in front of the iris. The other, called the posterior chamber, is a narrow space behind the iris and is surrounded by a mucsuloepithelial structure called the ciliary body. Aqueous humor is contiuously formed into the posterior chamber by the double layer ciliary epithelium that covers the ciliary body. Aqueous humor then sips through the hole at the center of iris, called the pupil, into the anterior chamber. Excess aqueous humor leaves the anterior chamber, by a pressure dependent way, mainly through a sieve-like structure called the trabecular meshwork located at the junction of the cornea and the sclera. Apart from supplying the nutrients and removing metabolic wastes from the avascular tissues of the eye, namely, the cornea, trabecular meshwork and the lens, the aqueous humor maintains the optimum ...
accommodation: ability of the lens to adjust its shape for vision at various distances in order to produce a clear image on the retina.. anterior chamber: space in front portion of the eye between the cornea and the iris and lens, which is filled with aqueous humor. aqueous humor: clear, watery fluid that fills the anterior chamber and the posterior chamber in the front part of the eye and provides nutrients to structures in the anterior chamber.. aqueous outflow pathway: the main exit route of aqueous humor from the eye, including the trabecular meshwork and Schlemms canal.. astigmatism: irregular curvature of the cornea or lens resulting in a distorted image because light rays are not focused on a single point on the retina.. binocular vision: coordinated use of the two eyes to see a single fused three-dimensional image.. blindspot: in testing the visual field, this is the blind area corresponding to the optic disk where the optic nerve fibers exit the eye and where there are no ...
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood. Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all hallmarks of POAG in humans. We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, ...
Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). Aqueous humor flows through Schlemms canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. However, the mechanisms underlying increased AHO resistance are poorly understood. Here, we demonstrate that signaling between angiopoietin (Angpt) and the Angpt receptor Tie2, which is critical for SC formation, is also indispensable for maintaining SC integrity during adulthood. Deletion of Angpt1/Angpt2 or Tie2 in adult mice severely impaired SC integrity and transcytosis, leading to elevated IOP, retinal neuron damage, and impairment of retinal ganglion cell function, all hallmarks of POAG in humans. We found that SC integrity is maintained by interconnected and coordinated functions of Angpt-Tie2 signaling, AHO, and Prox1 activity. These functions diminish in the SC during aging, ...
Relationship between the severity of macular edema and the aqueous humour concentrations of cytokines.A. IL-1β. B. IL-6. C. IL-8. D. IP-10. E. MCP-1. F. VEGF.
J Room Physiol 143:439В444 de Carvalho EF, de Castro FT, Rondinelli E, Carvalho JF (1994) Physiological aspects of Trypanosoma cruzi gene control during heat-shock. P2X4 receptors induced in spinal microglia barrier tactile allodynia after tenacity injury. 1 pct of men and 21 buy 5 mg proscar with visa prostate cancer questions. In its original 2 years, the GOG was in discus- sions with the Childrens Oncology Set (RATCHET) to col- laborate on a usage for the benefit of scrutiny inasmuch as low-risk disease and compressed BEP repayment for intermediate-risk disease. They like using toys in behalf of their intended tenacity as beyond the shadow of a doubt as for whatever invented ambition they can imagine. You pot motley this likewise cheap super cialis 80 mg free shipping erectile dysfunction medication australia. Peak aqueous humor concentrations of triamcinolone ranged from 2,151 to 7,202 ng/mL, half-life 76В635 h, and AUC0Вt 231 to 1,911 ng h/mL following celibate intravitreal ...
This study was conducted to investigate therapeutic value of a soluble tumor necrosis factor-alpha (TNF-alpha) receptor, etanercept, in a rat model of endotoxin-induced uveitis (EIU). Forty-two inbred male Lewis rats were divided into seven equal groups. 200 mug of Escherichia coli 055:1355 lipopolysaccharide, (LPS) was injected in one hind footpad of the Groups 2, 3, 4, 5, 6, and 7 rats. Group 5, 6, and 7 rats also received subcutaneous etanercept 24 hr prior to LPS injection at a dose of 0(.)4 mg kg(-1). Group 1 rats were used as controls. Eight, 24, and 48 hr after treatment clinical uvetis scores (miosis, iris hyperemia, and hypopyon) were assessed by a masked observer and the rats were euthanized. Neutrophil leukocytes, CD8 +, CD4 +, and CD45RO + cells in the anterior uveal tissue were counted either after hematoxylin-eosin or monoclonal antibody staining. TNF-alpha. levels were also measured in the aqueous humor samples by an ELISA method. Etanercept treatment significantly improved ...
Glaucoma is a disease of the eye where there is an increase in the pressure within the eye, this is called the intraocular pressure. This disease can be quite painful and will often result in blindness. An increase in intraocular pressure is caused by the globe of the eye being unable to drain. Inside the eye is the ciliary body, this structure not only contains the ligaments that hold the lens in place and helps it focus it also produces aqueous humor. Aqueous humor is a fluid that provides nutrition to the eye, helps the eye maintain its shape due and provides the intraocular pressure of the eye. Aqueous humor is located in the anterior chamber of the eye which is the front most chamber between the cornea and the iris. This fluid is being constantly produced by the ciliary body, in order to maintain homeostasis in the eye it must drain at a commensurate rate. The area where drainage occurs is called the iridocorneal angle. When the eyes drainage of aqueous humor does not keep up with its ...
The most critical risk factor for optic nerve damage in cases of primary open-angle glaucoma (POAG)(31) is an increased intraocular pressure (IOP) due to alternation of tissues in the eye located around the base of the cornea(32). Actin, a critical player in many cellular functions, including cell motility and the maintenance of cell shape, etc.(33), disruption or taken over actin cytoskeleton by numerous pathogens(34), may induce a resistance to aqueous humor outflow in the trabecular meshwork (TM)(36), an area of tissue is responsible for draining the aqueous humor from the eye via the anterior chamber causes of optic nerve damage involved connective tissue growth factor (CTGF), found in higher amounts in the aqueous humor of patients with POAG(35 ...
Orientation: Using humour in diversity contexts may relieve tension temporarily, but it happens at the expense of someone and indicates a defence against an unconscious anxiety dynamic. Research purpose: The purpose of this research was to describe the manifestation of humour as a defence mechanism against diversity anxiety. Motivation for the research: In working with diversity dynamics in South African organisations, consultants and participants often do not take humour seriously, let alone interpret the accompanying dynamic aspects. Working below the surface with humour may elicit much more and typical diversity dynamics worth investigating. Research design, approach and method: The research design was qualitative and descriptive, using multiple case studies and content analysis. Main findings: Humour is used as a defence against the anxiety experienced in diversity contexts caused by fear of the unknown within the self and the projection of the fear onto another identity group. ...
Its not just what we say that matters, but how we say it when it comes to building a great, safe culture, said Kerr. Humour makes people more approachable; it helps build connections and relationships and break down walls. Humour not only helps messages stand out, relevant humour reduces the counter-argument part of the brain - that part of peoples brains where they immediately start building arguments about why they are not going to do something - so people are more accepting of a message, said Kerr.. If you deliver a message, a rule, a regulation, a safety policy with a little bit of humour, studies show people are five times more likely to go along with you if you do it in a funny way, he said.. Some ways to do this are by using a top 10 list, opening with a funny story, using humour in safety videos - just doing something to add a little bit of humour into the mix.. We need to make sure we are coming up with creative opportunities to share our messages in more fun ways so we are truly ...
Disclaimer: This is a medical humor and parody website meant solely for entertainment purposes, and is not intended to recommend or advise regarding the prevention, diagnosis, or treatment of any medical illness or condition. Stories and articles are meant only to provide a brief, fleeting distraction from the wretchedness of reality, and are not intended to be insensitive, callous, or offensive, or to otherwise belittle the plight of those affected with any medical disease, condition, or illness. All names and descriptions of people are fictitious except for those of well-known public figures, who are the subject of satire. Any resemblance to actual persons or events is purely coincidental. Medical Humor is just that: Medical Humor.. ...
Objectives Improve understanding of positive and negative humor. Increase knowledge of how humor affects our physical, psychological and social wellbeing. Focus on the use of humor for persons with Short Term Memory Loss, and their caregivers. Set out techniques to improve utilization of humor and exposure to humor in daily life. Laugh and tell a few illustrative jokes.
The Short Humour (Humor) Site aims to promote the reading and writing of Short Humour (Humor) both in Britain and throughout the world and also to showcase work by writers of the genre.
Synonyms for cardinal humours in Free Thesaurus. Antonyms for cardinal humours. 54 synonyms for humour: comedy, funniness, fun, amusement, funny side, jocularity, facetiousness, ludicrousness, drollery, comical aspect, mood, spirits, temper. What are synonyms for cardinal humours?
Genetic heterogeneity of primary open-angle glaucoma, and concentration changes of various inflammation and immune response mediators in the blood, aqueous humor or tissues, indicate the involvement of different genetic mechanisms and immune system activity in the pathogenesis of POAG. The aim of study was to determine the interdependent clinical, genetic and biochemical findings in POAG-HTG patients. Distribution of genetic polymorphisms for TNF-α -308 G/A and - 863 C/A in DNA samples was examined using PCR-RFLP, the concentrations of circulating TNF-α and HSP 70 in a plasma and concentration of sFas and sFasL in the aqueous humor were measured by commercial ELISA tests. Their association with quantitative clinical parameters was examined. This study included 357 subjects: 81 POAG-HTG, 35 PEXG, 77 with senile cataract and 164 healthy subjects age-sex matched. Furthermore, 35 samples of aqueous humor of POAG-HTG patients , 24 PEXG and 29 with senile cataract were treated. The results s...howed ...
Methods of treating ocular disorders are disclosed, such as a method that includes inserting an implant in eye tissue, using a delivery instrument, such that an inlet portion of the implant is in an anterior chamber of an eye and an outlet portion of the implant is in a physiological outflow pathway; removing the delivery instrument from the eye without removing the implant; and conducting fluid comprising a therapeutic substance through the implant and into the physiological outflow pathway. Another method includes inserting an instrument into a physiologic outflow pathway through which aqueous humor drains from an anterior chamber of an eye; separating first and second walls of tissues which comprise the physiologic outflow pathway by injecting a fluid comprising a drug from the instrument while the instrument remains in the physiologic outflow pathway; and withdrawing the instrument following the injection with said fluid remaining within the eye such that the drug has a therapeutic effect on the eye
Shunt devices and a method for continuously decompressing elevated intraocular pressure in eyes affected by glaucoma by diverting excess aqueous humor from the anterior chamber of the eye into Schlemms canal where post-operative patency can be maintained with an indwelling shunt device which surgically connects the canal with the anterior chamber. The shunt devices provide uni- or bi-directional flow of aqueous humor into Schlemms canal.
The healthy eye is filled with a clear fluid called aqueous humor which circulates inside the front portion of your eye. Your eye continually produces a small amount of aqueous humor while an equal amount flows out of your eye in order to maintain a constant healthy eye pressure. Glaucoma means that the aqueous humor is not flowing out of your eye properly and that pressure in the eye is building up. This pressure can cause damage to your optic nerve over time.. Early detection is key with glaucoma. People of any age with glaucoma symptoms or glaucoma risk factors, such as diabetes, family history of glaucoma, or those of African descent, should see an ophthalmologist regularly.. ...
Thank you for visiting us at the Childrens Humor Study!. We would like to invite you and your child to consider participation in an exciting new research study to increase our understanding of the development of humor.. In this study we aim to examine the brain development and function, specifically as it relates to cognition and humor. We are currently seeking typically-developing children (ages 6-12) who are native English-speakers. For more information about our research findings related to humor in adults, please read our labs publications. If you are interested in learning more abour our current study, please read through this website.. Study Goals:. This study is directed by Drs. Allan Reiss (Stanford University) and Jessica Black (Boston College). The goals of the study are to:. ...
The aqueous humor is a clear fluid that maintains the integrity of the eye. It is produced by the ciliary body and passes through the trabecular meshwork and Schlemms canal. Intraocular pressure (IOP) is determined by the amount of aqueous humor secreted, coupled with the rate of clearance from the eye. An elevated IOP leads to optic nerve deterioration and associated irreversible functional vision loss.[1][2]
Anterior chamber. The space inside the eye between the corneal endothelium (innermost layer of the cornea) and the iris. This space is filled with fluid called the aqueous humor.. Aqueous (A-kwee-us), aqueous humor. Clear watery substance filling the space between the cornea and the vitreous. The fluid contains nutrients that nourishes certain structures of the eye. It also plays a role in maintaining the intra ocular pressure (IOP), and in the normal state maintains a fine balance between its production and its drainage.. Conjunctiva (kohn-junk-TI-vah). Transparent mucous membrane covering the outer surface of the eyeball. It is continuous with the inner part of the upper and lower eyelid (fornices).. Cornea (KOR-nee-ah). This is the transparent structure at the front of the globe. It provides a pathway for light to enter the front part of the eye in order to reach the retina, playing an integral part of the refractive power of the eye.. Crystalline lens. The eyes natural lens is usually a ...
Monocytes have been shown to normally circulate through the trabecular meshwork (TM) and to be recruited in increased numbers to the TM following the applicatio...
Clear liquid called aqueous humor circulates inside the front portion of the eye. To maintain a healthy level of pressure within the eye, a small amount of this fluid is produced constantly while an equal amount flows out of the eye through a microscopic drainage system. (This liquid is not part of the tears on the out surface of the eye.). Because the eye is a closed structure, if the drainage area for aqueous humor - called the drainage angle - is blocked, the excess fluid cannot flow out of the eye. Fluid pressure within the eye increases, pushing against the optic nerve and causing damage.. Who is at risk for glaucoma? ...
A device is made up of one piece, or two independent pieces, that can be linked with each other to make a unit. The anterior end of a drainage tube is introduced 2 mm into the anterior chamber of the eye while the rear end of the tube is placed in the scleral lake. A cover is a plane body slight in height and oval or oblong in format that is provided with four parallel cuts that create two girths. The said girths are used to retain the drainage tube below the cover, thus creating a curvature in it to form a concave inner surface and a convex outer surface.
A method and apparatus for measuring an apparent depth of a section of an animal body are disclosed. Light is focused concurrently to an extended focal region comprising a plurality or continuum of measurement locations. Light reflected by a refractive index interface coincident with one of the plurality of measurement locations is detected. Detected light signals are generated from light reflected from first and second interfaces respectively defining the section under investigation, so that the apparent positions of the interfaces may be derived. A confocal arrangement and an axicon element may be employed. Preferably, the section is the aqueous humor of an eye. From changes in its refractive index corresponding changes in glucose concentration in the aqueous humor and, in turn, in the bloodstream of a patient may be derived, offering a non-invasive monitoring means for diabetic patients. Other compounds and structures of the body may alternatively be investigated.
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सामान्यतः यह रोग 40 वर्ष से अधिक आयु के बीच पाया जाता है। फिर भी कुछ मामलों में यह नवजात शिशुओं, मधुमेह, आनुवांशिकता, उच्च रक्तचाप व हृदय रोग इस रोग के प्रमुख कारणों में है।. आंखों में स्थित कार्निया के पीछे आंखों को सही आकार और पोषण देने वाला तरल पदार्थ (Aqueous Humour) होता है। सीलियरी उत्तक इस तरल पदार्थ को लगातार बनाते रहते हैं। ग्लूकोमा में आंखों की बहाव नलिकाओं का मार्ग रुक जाता है, लेकिन ...
Aqueous angiography facilitates increased understanding of aqueous humor outflow that can provide individualized treatment for IOP control.
We report here the results of our experience with the use of PCR for the identification of T. gondii in blood and aqueous humor samples from patients with and without ocular toxoplasmosis. Currently, the clinical diagnosis of ocular toxoplasmosis is based on the observation of a necrotizing lesion on the fundus, response to treatment, and serologic determination. However, in cases of atypical retinitis or when the fundus is hidden by vitreal inflammation, establishment of a diagnosis by ophthalmological examination alone can be difficult. In such cases the aqueous humor analysis may be used as a diagnostic tool for confirmation of ocular toxoplasmosis. Determination of intraocular production of antitoxoplasmic antibodies has been performed previously, but the results obtained had erratic values (2, 21). PCR has mostly been used to detect T. gondii in different biological samples (4, 9, 12, 14,19). Aqueous humor samples from patients with ocular toxoplasmosis have also been used with the PCR ...
Background: To evaluate the ability of topical ibopamine 2% to detect outflow resistance by comparing it with the tonography test in eyes with ocular hypertension (OHT). Methods: 62 eyes with OHT and 33 control eyes were included in this prospective study. Tonography was done manually as a standard outflow facility measurement. We used a C value of 0.18 mu l/min/ mm Hg or less and a P-o/C value of 100 and above as a positive tonographic test. The ibopamine test performed on the following day was considered positive if there was an intraocular pressure (IOP) change of at least 3 mm Hg. Results: The sensitivity of the tonography and ibopamine tests was 69 and 53%, respectively, in eyes with OHT. The specificity of both tests was 97%. Although the sensitivity of the tonography test is higher than that of the ibopamine test, the difference between both was not statistically significant in these eyes ( p = 0.409). Positive results in tonography were associated with higher IOP, while the results were ...
TY - JOUR. T1 - Significant variation of the elevated nitric oxide levels in aqueous humor from patients with different types of glaucoma. AU - Tsai, Der Chong. AU - Hsu, Wen-Ming. AU - Chou, Ching Kuang. AU - Chen, Shih Jen. AU - Peng, Chi Hsien. AU - Chi, N. Wen. AU - Ho, Larry L.T.. AU - Liu, Jorn Hon. AU - Chiou, Shih Hwa. PY - 2002/12/1. Y1 - 2002/12/1. N2 - Though several studies have shown that the biochemical function of nitric oxide (NO) in the eye might play an important role in the regulation of intraocular pressure (IOP), local control of ocular blood flow and loss of retinal ganglion cells by apoptosis, it is unclear whether the role of NO is similar in the pathogenesis of different kinds of glaucoma: primary open-angle glaucoma (POAG), chronic closed-angle glaucoma (CCAG) and neovascular glaucoma (NVG). To further explore this issue, we measured the concentrations of NO in aqueous humor and plasma samples from patients with POAG (n = 31 ), CCAG (n = 76), NVG (n = 8) and cataract (n ...
In our study, 2PM was used to image the trabecular drainage channels of intact enucleated rat eyes. Due to the intrinsic properties of drainage tissue, autofluorescence from collagen fibers can be used to image the microstructure of the pathway. Compared to external fluorescent label, autofluorescence can avoid tissue damage caused by fluorochrome. Meanwhile, 2PM is suited to tissue imaging under the sclera, and has been successfully used to image living skin at a depth of 350 μm by visualizing the 2PAF of the skins extracellular matrix and melanin [19]. Most importantly of all, we were able to successfully get the high resolution images under high scattering tissue of eye. Our imaging had a lateral resolution of 2 μm, and a depth resolution of 1 μm. It is found that the high resolution imaging can achieve resolution of tissue section, and can avoid tissue distortions caused by infusion of fixatives.. Aqueous humor drains into aqueous vein through TM region firstly. In this progress, TM and ...
The major risk factor for most glaucomas and focus of modeling and treatment is increased intraocular pressure. Intraocular pressure is a function of production of liquid aqueous humor by the ciliary body of the eye and its drainage through the trabecular meshwork. Aqueous humor flows from the ciliary bodies into the posterior chamber, bounded posteriorly by the lens and the zonule of Zinn and anteriorly by the iris. It then flows through the pupil of the iris into the anterior chamber, bounded posteriorly by the iris and anteriorly by the cornea. From here the trabecular meshwork drains aqueous humor via Schlemms canal into scleral plexuses and general blood circulation. In open angle glaucoma there is reduced flow through the trabecular meshwork; in angle closure glaucoma, the iris is pushed forward against the trabecular meshwork, blocking fluid from escaping ...
Interest in the linguistics of humor is widespread and dates since classical times. Several theoretical models have been proposed to describe and explain the function of humor in language. The most widely adopted one, the semantic-script theory of humor, was presented by Victor Raskin, in 1985. Its expansion, to incorporate a broader gamut of information, is known as the General Theory of Verbal Humor. Other approaches are emerging, especially in cognitive and corpus linguistics. Within applied linguistics, the predominant approach is analysis of conversation and discourse, with a focus on the disparate functions of humor in conversation. Speakers may use humor pro-socially, to build in-group solidarity, or anti-socially, to exclude and denigrate the targets of the humor. Most of the research has focused on how humor is co-constructed and used among friends, and how speakers support it. Increasingly, corpus-supported research is beginning to reshape the field, introducing quantitative concerns, as well
Our image of Roman satire has developed from that of a static, moralizing genre to a deliberately complex form, but our approach to the humour intrinsic to satire has not developed accordingly. This book offers a comprehensive new analysis of humour in the writings of Horace, Persius, and Juvenal, with an excursus to Lucilius. The main thesis is that far from being an external means of sweetening the moral lesson, humour lies at the heart of Roman satire and shapes its paradoxical essence. The book argues that while the satirist needs humour for the aesthetic merit of his work, his ideological message inevitably suffers from the ambivalence that humour carries. By analyzing object-oriented humour, humour directed at the speaker (including self-irony), and humour directed at neither object nor subject, the book shows how the Roman satirists work round this double mission of morals and merriment. As a result, they present the reader with a much more sprawling and open literary product than they promise
Aim: To measure the genomic DNA of human herpes viruses (HHV) in the ocular fluids and to analyze the clinical relevance of HHV in uveitis. Methods: After informed consent was obtained, a total of 111 ocular fluid samples (68 aqueous humor and 43 vitreous fluid samples) were collected from 100 patients with uveitis. The samples were assayed for HHV-DNA (HHV1-8) by using two different polymerase chain reaction (PCR) assays, qualitative PCR (multiplex PCR) and quantitative PCR (real-time PCR). Results: In all of the patients with acute retinal necrosis (n=16) that were tested, either the HSV1 (n=2), HSV2 (n=3), or VZV (n=11) genome was detected. In all patients, high copy numbers of the viral DNA were also noted, indicating the presence of viral replication. In another 10 patients with anterior uveitis with iris atrophy, the VZV genome was detected. When using multiplex PCR, EBV-DNA was detected in 19 of 111 samples (17%). However real-time PCR analysis of EBV-DNA indicated that there were only 6 ...
Read Isoforms of TGF-β in the aqueous humor of patients with pseudoexfoliation syndrome and a possible association with the long-term stability of the capsular bag after cataract surgery, Graefe
The FM-700 aqueous flare meter (also known as a Laser Flare Meter) enhances the follow up of patients by enabling the in-vivo measurement of aqueous flare in a non-contact, non-invasive and painless manner. The quantitative and reproducible measurement of aqueous flare it provides is known to be useful in cases of uveitis and following IOL implantation, and increased levels of flare have been reported with many other ocular conditions. This latest generation of the Kowa aqueous flare meter has been designed to combine the ultimate in efficiency and accuracy providing fast detection of ocular inflammation and subclinical change of inflammation levels ...
Levels of Aqueous Humor Trace Elements in Patients with Non-Exsudative Age-related Macular Degeneration: A Case-control Study. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
A device and method are provided for improved treatment of elevated intraocular pressure due to glaucoma. A trabecular shunting device is adapted for implantation within the trabecular meshwork of an eye such that aqueous humor flows controllably from the anterior chamber of the eye to Schlemms canal, bypassing the trabecular meshwork. The trabecular shunting device may utilize a quantity of pharmaceuticals effective in treating glaucoma, which are controllably released from the device into cells of the trabecular meshwork and/or Schlemms canal. Depending upon the specific treatment contemplated, pharmaceuticals may be utilized in conjunction with the trabecular shunting device such that aqueous flow either increases or decreases as desired. Placement of the trabecular shunting device within the eye, and release of a glaucoma medication therefrom, can arrest or slow the progression of glaucoma.
This study has outlined the rate and duration of penetration of tritiated prednisolone into the aqueous humor following a single clinical dose. The prednisolone
GLAUCOMA Should you be targeting collector channels with MIGS? by Liz Hillman Editorial Co-Director Targeting an area with increased pigmentation and blood reflux into Schlemms canal (red line) adjacent to a blue mark on the cornea (black line) that identified a collector channel Source: Paul Harasymowycz, MD With newer stenting devices bypassing the trabecular meshwork or
ធម្មតា ការផលិតទឹកក្នុងភ្នែករបស់យើង (Aqueous humour) ចាប់ផ្តើមចេញពីគល់ប្រស្រីភ្នែក (Ciliary body) ដែលជាកន្លែងផលិត បន្ទាប់មកវាហូរមកបន្ទប់ផ្នែកខាងក្រោយ រួចបន្តមកបន្ទប់ភ្នែកខាងមុខ ហើយត្រូវបានស្រូបចេញតាមចម្រោះ Trabecular Meshwork និងបន្តចេញមកតាម បំពង់តូច (Schlemms canal) ហើយចុងបញ្ចប់ជ្រាបតាមសរសៃវ៉ែន (Episcleral vein) ...
Looking for Humor, Vampire? Find out information about Humor, Vampire. Mel Brookss Dracula: Dead and Loving It is a prime example of vampire humor. Leslie Neilsen played the hapless Count Dracula. Legendary Dracula actor... Explanation of Humor, Vampire
A new study shows that patients with glaucoma or ocular hypertension (OHT) and recurrent anterior uveitis have a reduced tonographic outflow-lower than patients without glaucoma or OHT-but an actual aqueous flow that is not statistically any different from patients without glaucoma or OHT. Researchers from St. Thomas Hospital in London divided 92 patients into three groups. Group one had patients with recurrent anterior uveitis (three or more attacks) and were being treated for glaucoma or OHT. Group two patients had experienced previous recurrent anterior uveitis without glaucoma or OHT. The third group, the controls, had no ocular problems and IOP less than 21mm Hg. They found that the tonographic outflow facility was approximately 0.18 in group one, 0.25 in group two and 0.27 in the control group. However, the aqueous flow rate in group one was 2.47μl/min, in group two it was 2.13μl/min and 2.25μl/min in the control. The investigators say this demonstrates that the elevated IOP seen in the ...
Of all cases with positive PCR for the herpes virus family in intraocular samples taken between 2007 and 2016, only those with VZV and HSV1 or HSV2 met the criteria for ARN. None of the 12 patients with CMV, one patient with EBV and one patient positive for both viruses, exhibited signs of ARN clinically, which is in keeping with Takase et al.6 Some authors suggest EBV and CMV as possible causes.3 4 19 These viruses usually affect immunocompromised patients and typically have a different clinical picture. Lau et al as well as Hillenkamp et al reported that patients with ARN who tested EBV positive with PCR also were positive for VZV.20 21 Low levels of EBV in conjunction with high levels of VZV has also been reported in cerebrospinal fluid in viral CNS disease.15 In this material, we did not find positivity for multiple viruses in the same sample as none of patients with ARN had CMV DNA in intraocular fluids and the four samples analysed for EBV DNA were also negative. The hypothesis that ARN is ...
Contemporary research began investigating the physiology and therapeutic effects of humor and in fact some believe that humor accomplishes the same goal as physical exercise. Some humor -laughter research findings are as follows:1. Humor experience leads to arousal of the sympathetic nervous system 2.Epinephrine is a precondition for physiological arousal 3. Arousal as measured by heart rate and skin conduction increases with the intensity of the response to something humorous 4. Laughter increases respiration, oxygen exchange, muscular activity, heart rate , stimulates the cardiovascular system , the sympathetic nervous system and the production of catecholamine 5. Blood-pressure is also reduced in a state similar to that resulting from exercise. 6. Increases in systolic and a diastolic blood-pressure is related to the intensity and length of the laughter .Blood pressure levels decreased after laughter to below pre-laughter levels.7 There is greater coordination of function between the right ...
The Kahook Dual Blade (KDB) is an single-use ophthalmic blade with a micro-engineered profile which allows for insertion into the eye through a clear cornea micro-incision. It can be done with or without cataract surgery, and when done in conjunction with cataract surgery it is done following lens removal through the same incision utilized for the cataract removal. The device is made of surgical grade stainless steel body with a long, thin shaft that allows for access across the anterior chamber to the trabecular meshwork (TM). Using a special mirrored lens, the surgeon uses the Kahook Dual blade to make parallel incisions in the trabecular meshwork (TM), un-roofing it and opening up into inner wall of the Canal of Schlemm to improve aqueous humor outflow from the eye in an effort to reduce the eye pressure. This procedure does not involve opening up the conjunctival tissues; this is a major advantage of this procedure as it makes future glaucoma surgery (if needed) a lot simpler with less risk ...
Treatment for glaucoma is directed at restoring both vision and comfort. This requires an accurate assessment of the extent and duration of the pressure elevation. In eyes which have the potential for return of functional vision (no globe enlargement, duration less than one week), immediate medical therapy is used to initially reduce the pressure. This is followed by a choice of surgical options to attempt to permanently normalize the pressure. Medical management is rarely successful long-term due to recurrent pressure elevation and drug toxicity.. The diode laser is used to treat glaucoma through photocoagulation of the ciliary body. A 1 mm probe is applied to the sclera 2-2.5 mm posterior to the limbus to deliver 2.5-3.5 joules (2.5 mwatts for 1000-1400 msec) of energy to the ciliary body over 20-30 sites. This results in localized destruction of the secretory epithelium of the ciliary body thus reducing aqueous humor production. There is also some increase in extrascleral outflow of aqueous ...
Heres another Observational Humor monologue presented at the end of a meeting. Remember that the purpose of developing a monologue isnt to become a stand-up comic. The skill of creating in-the-moment jokes enables you to be totally present when you give an important speech. You develop the capability to create just one or two strong, fresh jokes to open your planned talk, giving an appearance of spontaneity to your prepared speech. The jokes provided in this monologue are not intended to make you laugh. To really appreciate the humor you had to be there. And you werent. They are provided as examples of how to create Observational Humor lines, which is a valuable skill to have.. THE SET-UP (What was said and what happened during the meeting before the monologue was presented.). 1. Professional Speaker Melanie said that she charges $1000 for the first fifteen minutes.. 2. Melanie said she spends so much time at home practing her speeches that her dog has started to move his lips when shes ...
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Whats funny? A definition of humor and humor theories - Irina Wamsler - Akademische Arbeit - Amerikanistik - Linguistik - Publizieren Sie Ihre Hausarbeiten, Referate, Essays, Bachelorarbeit oder Masterarbeit
First, we found that the level of soluble HS is positively correlated with age in vitreous samples from idiopathic maculopathies. We then showed that soluble HS levels in aqueous humor were lower in younger diabetic subjects with retinal NVs than in older diabetic subjects without retinal NVs or in nondiabetic subjects with cataract; the difference was no longer significant after controlling for the ages in these groups. The lack of correlation between severity of retinopathy and HS levels suggests that reduced HS levels in the aqueous humor in younger PDR patients could be explained at least in part by age and not by the severity of retinopathy. While the observation appears to contradict the reported correlation between reduced HS levels in the kidney and the diabetes mellitus [16-18], our study does not exclude the possibility of a less significant contribution of diabetes mellitus to ocular levels of HS. Analysis of the intraocular fluid from nondiabetic controls age-matched for PDR and a ...
Press Release Nicox and pSivida Enter Strategic Collaboration Agreement to Develop Sustained Release Drug to Lower Intraocular Pressure in Patients with Glaucoma Focus will be on Combining Nicox's New
History and purpose: Trabecular meshwork (TM) can be an ocular cells mixed up in rules of aqueous humour outflow and intraocular pressure (IOP). and mobilization of intracellular Ca2+ shops. A PTX-sensitive upsurge in extracellular signal-regulated kinase (ERK1/2) phosphorylation was also seen in response to WIN55 212 indicative of the Gi/o signalling pathway. CB1-Gq/11 coupling to activate PLC-dependent raises in Ca2+ were particular to WIN55 212 and werent observed with additional.. Read More. ...
Posterior chamber is an important structure involved in production and circulation of aqueous humor. Aqueous humor produced by ... "Flow of Aqueous Humor". yale. Harpreet Gill, MD Staff Physician, Henry Ford Ophthalmology (Sep 20, 2018). "Phacomorphic ... The block in flow of aqueous from the posterior to the anterior chamber will lead to a condition known as Iris bombe. In this ... Surgical management of Glaucoma due to Iris bombe include making a small hole in the iris which allows passage of aqueous from ...
Brubaker RF (1991). "Flow of aqueous humor in humans". Invest Ophthalmol Vis Sci. 32 (13): 3145-3166. PMID 1748546. Hashemi H, ... the rate of aqueous humour formation in microliters per minute (μL/min) U {\displaystyle U} the resorption of aqueous humour ... During the night, intraocular pressure may not decrease despite the slower production of aqueous humour. In the general ... Intraocular pressure is determined by the production and drainage of aqueous humour by the ciliary body and its drainage via ...
Eye surgery Glaucoma surgery Brubaker, Richard F. (1991-12-01). "Flow of Aqueous Humor in Humans [The Friedenwald Lecture]". ... Foo VH, Htoon HM, Welsbie DS, Perera SA (2019). "Aqueous shunts with mitomycin C versus aqueous shunts alone for glaucoma". ... are transscleral implants to channel aqueous humor into the non-dissected Tenon's space, creating a subconjunctival drainage ... due to the ongoing scarring over the conjunctival dissipation segment of the shunt may become too thick for the aqueous humor ...
So ibopamine can not be found in the aqueous humor after instillation. After being hydrolysed to epinine, ibopamine is able to ... It has been shown that the half-life of ibopamine is short to about 2 minutes in the aqueous humour owing to the fast ... Due to the esterases existing in the aqueous humour and ocular tissues, ibopamine can be rapidly hydrolysed to epinine which is ... In some randomized clinical trials, the D1 dopaminergic activity of ibopamine led to an increased production of aqueous humour ...
... which produces the aqueous humor. The aqueous humor is produced in the non-pigmented portion of the ciliary body. The ciliary ... and these secrete aqueous humor into the posterior chamber. The aqueous humor then flows through the pupil into the anterior ... Eighty percent of aqueous humor production is carried out through active secretion mechanisms (the Na+K+ATPase enzyme creating ... Because the ciliary body produces aqueous humor, it is the main target of many medications against glaucoma. Its inhibition ...
The buildup of protein clumps can block normal drainage of the eye fluid called the aqueous humor and can cause, in turn, a ... The eye produces a clear fluid called the aqueous humor which subsequently drains such that there is a constant level of safe ... and improve the outflows of the aqueous humor. These can be done as an outpatient procedure and take less than twenty minutes. ... and removes a tiny area of the trabecular meshwork which enables the aqueous humor to discharge. This lowers the internal ...
Aqueous humor fills these spaces within the anterior segment and provides nutrients to the surrounding structures. Some ... On the other side of the lens is the second humour, the aqueous humour, which is bounded on all sides by the lens, the ciliary ... the vitreous humor, retina, choroid, and optic nerve. The radii of the anterior and posterior sections are 8 mm and 12 mm, ...
The aqueous and vitreous humors both have a refractive index of 1.336-1.339, whereas the cornea has a refractive index of 1.376 ... The cornea takes in fluid from the aqueous humor and the small blood vessels of the limbus, but a pump ejects the fluid ... The corneal endothelium is bathed by aqueous humor, not by blood or lymph, and has a very different origin, function, and ... Because the change in refractive index between cornea and aqueous humor is relatively small compared to the change at the air- ...
In a healthy cornea, endothelial cells keeps the tissue from excess fluid absorption, pumping it back into the aqueous humor. ...
In posterior synechia, the iris adheres to the lens, blocking the flow of aqueous humor from the posterior chamber to the ... Anterior synechia causes closed angle glaucoma, which means that the iris closes the drainage way of aqueous humour which in ...
Add arteries and veins, aqueous humor, corneosclera. Resize tendons. Redraw ora serrata. ... Vitreous humor with 19. Hyaloid canal/(old artery), 20. Retina with 21. Macula or macula lutea, 22. Fovea and 23 Optic disc → ... 1. Lens, 2. Zonule of Zinn or Ciliary zonule, 3. Posterior chamber and 4. Anterior chamber with 5. Aqueous humour flow; 6. ...
... aqueous humor, or sputum. Stimulating light excites an electron, raising energy to an unstable level. This instability is ...
... is a circular lymphatic-like vessel in the eye that collects aqueous humor from the anterior chamber and ... On the inside of the canal, nearest to the aqueous humor, it is covered by the trabecular meshwork; this region makes the ... greatest contribution to outflow resistance of the aqueous humor. Conventionally, the canal has been considered a blood vessel ... delivers it into the episcleral blood vessels via aqueous veins.[1][2][3][4] It is named after Friedrich Schlemm (1795-1858), a ...
... enables the aqueous humor to circulate. When the animal is sleeping, REM provides the much-needed stir to aqueous humor. This ... he calculated that if aqueous humor was stagnant, oxygen from iris had to reach cornea by diffusion through aqueous humor, ... and that aqueous humor, the liquid between cornea and iris, was stagnant if not stirred.[105] Among the supportive evidences, ...
The endothelium is a single cell layer that separates the cornea from the aqueous humor. ... There may also be signs of anterior uveitis, such as miosis (small pupil), aqueous flare (protein in the aqueous humour), and ...
The vitreous does not undergo a regular formation and drainage process like the aqueous humor. Instead, it stays permanently in ... aqueous humour) which is continuously replenished, the gel in the vitreous chamber is stagnant. Therefore, if blood, cells or ... "Encyclopædia Britannica from Encyclopædia Britannica 2006 Ultimate Reference Suite DVD 2009 The Vitreous Humor Archived April ...
5α-Dihydrocortisol is present in the aqueous humor of the eye, is synthesized in the lens, and might help make the aqueous ... "5 alpha-dihydrocortisol in human aqueous humor and metabolism of cortisol by human lenses in vitro". Invest. Ophthalmol. Vis. ... humor itself.[39] 5α-Dihydroaldosterone is a potent antinatriuretic agent, although different from aldosterone. Its formation ...
... which were microfilariae moving freely in the aqueous humor of the anterior chamber of the eye. Blacklock and Strong had ...
... tears and aqueous humor). It could also minimize adverse drug effect to other body tissues via the systemic circulation, which ... Aqueous chlorhexidine is used instead in case of adverse effects to povidone-iodine. Next, an eyelid speculum is placed to ... The medication will be directly applied into the vitreous humor. It is used to treat various eye diseases, such as age-related ... which contains a mixture of vitreous humor and the drug administered) Floaters (black/grey spots, small shapes or string in ...
The reflex relies on the transparency of optical media (tear film, cornea, aqueous humor, crystalline lens, vitreous humor) and ...
... which facilitates flow of aqueous humor from the posterior to the anterior chamber of the eye. Surgical iridectomy is commonly ...
Lens Chambers of eyeball Aqueous humor Vitreous humor Accessory visual structures Extra-ocular muscles Orbitalis Superior ...
Decreased aqueous humor fluid production from the ciliary body The α subunit of an inhibitory G protein - Gi dissociates from ...
Research suggests that the exploitation of anterior chamber-associated immune deviation (ACAID), aqueous humor and its anti- ...
... aqueous humor MeSH A09.371.060.067.318 - endothelium, corneal MeSH A09.371.060.217 - cornea MeSH A09.371.060.217.113 - bowman ... blood-aqueous barrier MeSH A09.371.894.223 - choroid MeSH A09.371.894.223.250 - bruch membrane MeSH A09.371.894.280 - ciliary ...
... is made up of connective tissue and bathed in lacrimal fluid and aqueous humor, which provides it nutrition, as it does not ...
... aqueous humor, and vitreous humor) are replaced by an ideal air/water interface surface that is located 20 mm from a model ...
If the clear aqueous humor from the eye runs through the yellow stain, the patient tests positive for corneal perforation. ... Any aqueous leakage is revealed during the Seidel test confirms corneal perforation. A fluorescence strip is wiped over the ...
"Morphine-stimulated nitric oxide release in rabbit aqueous humor". Exp. Eye Res. 84 (1): 185-90. PMC 1766947. PMID 17094965. ...
Medications that lower intraocular pressure work by decreasing aqueous humor production and/or increasing aqueous humor outflow ...
Detachment is occasionally caused by contracture of fine collagenous fibrils in the vitreous humor, which pull areas of the ...
Thickening agents, or thickeners, are substances which, when added to an aqueous mixture, increase its viscosity without ... The ocular Vitreous humor is subject to rheologic observations, particularly during studies of age-related vitreous ...
... and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue ...
Glaucoma [16][21](As eye drops, they decrease intraocular pressure by lowering aqueous humor secretion.[22]) ...
Since the cornea has no blood vessels (it takes its nutrients from the aqueous humor) it heals much more slowly than a cut on ...
In the theory of the four bodily humors, water was associated with phlegm, as being cold and moist. The classical element of ... To observe the fundamental stretching absorption spectrum of water or of an aqueous solution in the region around 3500 cm−1 ( ... In industry, near-infrared spectroscopy is used with aqueous solutions as the greater intensity of the lower overtones of water ... calcium fluoride is one material that is in common use for the cuvette windows with aqueous solutions. ...
... aqueous humor, reproductive organs, and bone; highest concentrations occur in pleural fluid, interstitial fluid, peritoneal ...
... and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane ...
... the aqueous humor is drained.. Consistently with the laws of physics, the aqueous humor contained in the chamber with the ... aqueous humor can circulate from the concave lower part towards the convex upper part, creating two spaces of aqueous humor to ... Aqueous humor drainage device. US4750901. Mar 5, 1987. Jun 14, 1988. Molteno Anthony C B. Implant for drainage of aqueous ... Glaucoma aqueous humor drainage plate. EP0168201A1. Jun 27, 1985. Jan 15, 1986. Neil Howard Joseph. Aqueous humour drainage ...
Aqueous humor was obtained from five human donors diagnosed with primary open angle glaucoma (POAG) and five age- and sex- ... Changes to the Aqueous Humor Proteome during Glaucoma. by Logan Thomison , Oct 30, 2016 , 0 comments ... To investigate the aqueous humor proteome in patients with glaucoma and a control group. ... Expression levels of 87 proteins were found to be different between glaucomatous and control aqueous humor. Of the 87 proteins ...
Antonyms for aqueous humor. 1 synonym for aqueous humor: aqueous humour. What are synonyms for aqueous humor? ... Aqueous humor synonyms, aqueous humor antonyms - FreeThesaurus.com https://www.freethesaurus.com/aqueous+humor ... aqueous humor. Also found in: Dictionary, Medical, Legal, Encyclopedia.. Related to aqueous humor: choroid coat #vtZoom,.vt- ... Synonyms for aqueous humor. the limpid fluid within the eyeball between the cornea and the lens. Synonyms. *aqueous humour ...
Mechanisms of Aqueous Humor Homeostasis -- Role of Monocytes Alvarado, Jorge A. University of California San Francisco, San ... Mechanisms of Aqueous Humor Homeostasis -- Role of Monocytes. Alvarado, Jorge A. / University of California San Francisco. ... Mechanisms of Aqueous Humor Homeostasis -- Role of Monocytes. Alvarado, Jorge A. / University of California San Francisco. $ ... Mechanisms of Aqueous Humor Homeostasis -- Role of Monocytes. Alvarado, Jorge A. / University of California San Francisco. $ ...
Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were ... Aqueous humor xanthine levels were not significantly different from plasma; aqueous humor hypoxanthine concentrations were ... in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor ... in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor ...
RESULTS: Log10 HCV RNA levels were found to be 6.00 ± 1.06 IU/mL in serum, 2.76 ± 0.36 IU/mL in the aqueous humor, and 1.91 ± ... The Investigation of HCV RNA in Tear Fluid and Aqueous Humor in Patients with Anti-HCV Antibody Positive Who Underwent Cataract ... PURPOSE: To obtain aqueous humor and tear fluid samples during cataract surgery of the hepatitis C virus (HCV)-antibody- ... CONCLUSIONS: Although viral load detected in aqueous humor and tear fluid samples was considerably lower compared to the serum ...
Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor ... Topical glucocorticoid therapy directly induces up-regulation of functional CXCR4 on primed T lymphocytes in the aqueous humor ...
Aqueous Humor related anatomy. *Aqueous Humor. *Clear fluid that fills anterior and posterior chamber ... Aqueous Humor, Aqueous Outflow Angle. ... Eye Anatomy, Limbus Corneae, Iris, Conjunctiva, Aqueous Humor, ...
The bulk of aqueous humor passing through the conventional outflow pathway must cross the inner wall endothelium of Schlemms ... SC pore density is reduced in glaucoma, possibly contributing to obstructed aqueous humor outflow and elevated intraocular ...
Intraocular pressure (IOP) is determined by the amount of aqueous humor secreted, coupled with the rate of clearance from the ... The aqueous humor is a clear fluid that maintains the integrity of the eye. It is produced by the ciliary body and passes ... The aqueous humor is a clear fluid that maintains the integrity of the eye. It is produced by the ciliary body and passes ... The ultimate result is a reduction in aqueous humor and a lowering of IOP. This is achieved by several mechanisms that ...
Aqueous humor cytokine profiling in patients with wet AMD.. Liu F1, Ding X1, Yang Y1, Li J1, Tang M1, Yuan M1, Hu A1, Zhan Z1, ... Undiluted aqueous humor samples (100-200 μl) were obtained from 16 wet AMD eyes and 12 control eyes. Forty chemokines were ... Compared with the control group, the aqueous humor in wet AMD patients showed a significantly higher expression of CXCL10 (p= ... To investigate the chemokine expression profiles in the aqueous humor of wet age-related macular degeneration (wet AMD) ...
This study finds that aqueous humor from retinoblastoma eyes contains tumor-derived DNA that can be analyzed as an alternative ... Aqueous humor biopsy may be an improvement over existing methods, as it could require less advanced technical skills and carry ... Evaluation of aqueous humor demonstrated tumor-derived, cell-free DNA and regions of chromosomal gains and losses, representing ... This study finds that aqueous humor from retinoblastoma eyes contains tumor-derived DNA that can be analyzed as an alternative ...
... J Ocul Pharmacol Ther. 2002 Oct;18(5):445- ... Analysis of aqueous humor samples obtained during surgery showed a 2.4-fold greater concentration of ofloxacin over ...
Effects of Selective Laser Trabeculoplasty on Aqueous Humor Dynamics. The safety and scientific validity of this study is the ... This study will determine the changes in aqueous humor dynamics produced by SLT that lead to its IOP lowering effect. SLT is a ... The effect of SLT on the aqueous humor dynamics is currently unknown. Given the lack of demonstrable thermal damage on ... This study will compare aqueous humor dynamics in adults with primary open angle glaucoma that receive Selective Laser ...
Detection, quantification, and signficance of basic fibroblast growth factor in the aqueous humor of man, cat, dog and pig ... Human Hepatocyte Growth Factor (HGF) in the Aqueous Humor * * ARAKI SASAKI Kaoru ... Presence of human epidermal growth factor, basic fibroblast growth factor in human aqueous 並木真理 ...
... sheds light on the importance of understanding aqueous outflow at a fundamental level and discusses aqueous humor outflow ... Huang comments on how aqueous angiography facilitates surgeons ability to place surgerie… ... sheds light on the importance of understanding aqueous outflow at a fundamental level and discusses aqueous humor outflow ... sheds light on the importance of understanding aqueous outflow at a fundamental level and discusses aqueous humor outflow ...
Intraocular cells as well as blood plasma contribute to the extracellular aqueous humor miRNome. The data suggest possible ... Our data illustrate the feasibility of miRNA analysis by NGS in small individual aqueous humor samples. ... MicroRNA Profiling in Aqueous Humor of Individual Human Eyes by Next-Generation Sequencing Invest Ophthalmol Vis Sci. 2016 Apr; ... The aqueous humor miRNA profile shows some overlap with published NGS-derived inventories of circulating miRNAs in blood plasma ...
Lidocaine concentration was measured in aqueous humor samples taken before surgery. RESULTS: With 3 drops, aqueous lidocaine ... Aqueous humor lidocaine concentrations in topical and intracameral anesthesia. Behndig, Anders Umeå University, Faculty of ... PURPOSE: To assess aqueous humor lidocaine concentrations in 2 common regimens of topical anesthesia and after intracameral ...
Aqueous Humor / metabolism*. Biological Assay. Cataract / etiology, metabolism, pathology. Cells, Cultured. Ciliary Body / ... Furthermore, aqueous humor from canine eyes with cataracts also contained significantly higher levels of TGF-beta 2 than normal ... Surprisingly, aqueous humor from aphakic rabbit eyes contained significantly higher levels of TGF-beta 2 than their ... METHODS: Lens and ciliary body epithelial cell culture supernatants and aqueous humors were assayed for total TGF-beta 2 levels ...
Notrox has vast experience in handling human aqueous humor sample analysis by liquid chromatography (LC)and mass spectrometry ( ... White Papers Human Aqueous Humor Sample Analysis Notrox Research Human Aqueous Humor Sample Analysis. 19 October 2017 Share ...
Absorption of Brimonidine Ophthalmic Solution in the Aqueous Humor of Cataract Patients. The safety and scientific validity of ... Absorption of Brimonidine Ophthalmic Solution in the Aqueous Humor of Cataract Patients.. ... The aqueous humor concentration 45 minutes following dosing of 0.1% Brimonidine Purite™ (pH 7.8) is comparable with 0.15% ... The purpose of this study is to obtain and assay human aqueous samples following pre-operative dosing with 0.1% Brimonidine ...
Metabolomics of the aqueous humor in patients with primary congenital glaucoma. Xueli Chen,1 Yuhong Chen,1 Li Wang,1 Xinghuai ... Ji Y, Rao J, Rong X, Lou S, Zheng Z, Lu Y. Metabolic characterization of human aqueous humor in relation to high myopia. Exp ... Barbas-Bernardos C, Armitage EG, García A, Mérida S, Navea A, Bosch-Morell F, Barbas C. Looking into aqueous humor through ... Amino acid pattern in human aqueous humor of patients with senile cataract and primary open-angle glaucoma. Ophthalmic Res. ...
Quantitative Analyses of Cytomegalovirus Genome in Aqueous Humor of Patients with Cytomegalovirus Retinitis * * ANDO Yasutaka ... Aqueous and vitreous humor samples for the diagnosis of cytomegalovirus retinitis MITCHELL SM ... An improved technique for the diagnosis of retinitis from samples of aqueous humor and vitreous GARWEG J ... Use of polymerase chain reaction assays of aqueous humor in the differential diagnosis of retinitis in patients infected with ...
Circadian Rhythms of Aqueous Humor Dynamics When Using Brimonidine in Humans With Ocular Hypertension. The safety and ...
... and the chemokine IL-8 comparing immune mediator concentrations in aqueous humor of patients with pOT (. ) and rOT (. ) and the ...
... a time when aqueous humor production is naturally low, will require measurement of all variables of aqueous humor dynamics ... Circadian Variation of Aqueous Dynamics in Young Healthy Adults. In Vivo Assessment of Aqueous Humor Dynamics Upon Chronic ... Circadian Variation of Aqueous Humor Dynamics in Older Healthy Adults Cherie B. Nau; Mehrdad Malihi; Jay W. McLaren; David O. ... Aqueous Humor Flow Rate, μL/min Outflow Facility, μL/min/mm Hg EVP, mm Hg Uveoscleral Outflow, μL/min ...
PubMed journal article Polymerase chain reaction for the detection of Toxoplasma gondii within aqueous humor of experimentally- ... Elevated interleukin 6 activity in aqueous humor of cats with uveitis.. *Toxoplasma gondii-specific antibodies in the aqueous ... Administration, OralAnimalsAntibodies, ProtozoanAqueous HumorBlotting, SouthernCat DiseasesCatsChorioretinitisDNA, Protozoan ... Serum and aqueous humor were collected from five SPF cats prior to oral inoculation with T. gondii and days 7, 14, 21, 28, 42, ...
... are present in human aqueous humor.. Methods: Undiluted aqueous humor samples were collected from 10 patients who underwent ... Poly-Unsaturated Fatty Acids in Human Aqueous Humor You will receive an email whenever this article is corrected, updated, or ... Results: The analysis of ten samples of aqueous humor demonstrated the presence of the omega-6 fatty acid linoleic acid (LA), ... Conclusions: We demonstrate the presence of omega-3 and omega-6 PUFAs in human aqueous humor. The omega-6 fatty acid, linoleic ...
... ... Methods40 consecutive cases of TRC with a positive aqueous humour (AH) tap for toxoplasmosis were retrospectively included. ...
... and TNF-β in the aqueous humor of patients undergoing femtosecond laser-assisted cataract surgery (FLACS) and corneal ... Aqueous humor was obtained at a different time point in the FLACS and corneal paracentesis groups. This was unavoidable due to ... The aqueous humor was assayed to determine the concentrations of cytokines using the FlowCytomix human Th1/Th2 11-plex BMS810FF ... Others have shown that concentrations of IL-1β, IL-6, and PGE2 in aqueous humor increase during FLACS compared to controls.5. ...
Since the aqueous humor passes directly into the venous system, the normal drainage process for aqueous humor is restored. ... may be connected to any source of aqueous humor, including the anterior chamber ( 1 ), an aqueous collector channel, Schlemms ... within the tissues of the eye to directly connect a source of aqueous humor such as the anterior chamber ( 1 ), to an ocular ... The invention provides minimally invasive microsurgical tools and methods to form an aqueous humor shunt or bypass for the ...
Buy The Eyes Aqueous Humor: From Secretion to Glaucoma by Civan, Mortimer M. at TextbookX.com. ISBN/UPC: 9780121746759. Save ... Description: This volume present a basic consensus of how the aqueous humor is formed and exits through the trabecular meshwork ... The Eyes Aqueous Humor: from Secretion to Glaucoma. by Civan, Mortimer M.. ... The Eyes Aqueous Humor: from Secretion to Glaucoma. by Civan, Mortimer M.. ...
... and in whom Toxocara-specific antibodies were also demonstrated in the aqueous humor. Two older siblings of this patients also ... Toxocara-Specific Antibody in the Serum and Aqueous Humor of a Patient with Presumed Ocular and Visceral Toxocariasis * * ... and in whom Toxocara-specific antibodies were also demonstrated in the aqueous humor. Two older siblings of this patients also ...
For blood and aqueous humor samples, 5 ml of anticoagulated blood and a 200- to 300-μl portion of aqueous humor, respectively, ... We report here the results of our experience with the use of PCR for the identification of T. gondii in blood and aqueous humor ... 1993) Detection of Toxoplasma gondii in aqueous humor by the polymerase chain reaction. Br. J. Ophthalmol. 77:107-109. ... The PCR was positive for 8 of the 15 blood samples and 7 of the 15 aqueous humor samples from patients in group 1. No ...
Aqueous Humor Outflow Imaging and the Clinic. Clinically, aqueous humor outflow and its segmental nature may play a role in ... For AHO, aqueous humor is actually made up of many components [66]. Predominately, aqueous humor is composed of water ( ... Figure 2: Aqueous angiography visualizes segmental aqueous humor outflow. Aqueous angiography was performed in the postmortem ... Figure 1: The Conventional Aqueous Humor Outflow Pathway. (A) Angle and aqueous humor outflow pathways can be visualized by ...
Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility. David Soto, Jesus ... Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility. David Soto, Jesus ... Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility. David Soto, Jesus ... Effects of dinucleoside polyphosphates on trabecular meshwork cells and aqueous humor outflow facility ...
The aqueous humor levels of PEDF in the high myopia and control groups were 4.01±2.21 and 3.08±1.89 pg/ml, respectively. PEDF ... The aqueous humor levels of VEGF in the high myopia and control groups were 26.12±13.74 and 59.46±24.64 pg/ml, respectively. ... Results: Aqueous humor levels of VEGF were significantly lower in the high myopia group compared to that in the control group ( ... Conclusions: Aqueous humor levels of VEGF in the high myopia group were significantly lower than those in the control group. ...
All aqueous humor (AqH) samples were tested for total protein concentration, ability to suppress in vitro T-cell activation, ... Aqueous humor reflects the microenvironment of the anterior chamber, and displays attributes that correlate with the immune ... We wished to determine whether immune privilege parameters assayed in aqueous humor are relevant to the fate of penetrating ... Immune privilege parameters assayed in aqueous humor prior to and after penetrating keratoplasty to correlate with graft ...
Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ... Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ... Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ... Pathological processes in aqueous humor due to iris atrophy predispose to early corneal graft failure in humans and mice ...
  • Changes to the Aqueous Humor Proteome during Glaucoma. (physiciansweekly.com)
  • To investigate the aqueous humor proteome in patients with glaucoma and a control group. (physiciansweekly.com)
  • Aqueous humor was obtained from five human donors diagnosed with primary open angle glaucoma (POAG) and five age- and sex-matched controls undergoing cataract surgery. (physiciansweekly.com)
  • Of the 87 proteins, 34 were significantly upregulated, whereas 53 proteins were downregulated in the aqueous humor from glaucoma patients compared to controls. (physiciansweekly.com)
  • Glaucoma leads to profound changes to the aqueous humor proteome consistent with an altered metabolic state, an inflammatory response and impaired antioxidant defense. (physiciansweekly.com)
  • Primary open-angle glaucoma (POAG) is often caused by elevated intraocular pressure (IOP), which arises due to increased resistance to aqueous humor outflow (AHO). (northwestern.edu)
  • An imbalance between the production of aqueous humor by the ciliary epithelium and its outflow through the trabecular meshwork can cause abnormally high intraocular pressure (above 20 mmHg), a painful condition called glaucoma. (arizona.edu)
  • Genetic heterogeneity of primary open-angle glaucoma, and concentration changes of various inflammation and immune response mediators in the blood, aqueous humor or tissues, indicate the involvement of different genetic mechanisms and immune system activity in the pathogenesis of POAG. (gov.rs)
  • Glaucoma means that the aqueous humor is not flowing out of your eye properly and that pressure in the eye is building up. (southern-eye.com)
  • Elevated intraocular pressure as the result of abnormal resistance to aqueous humor drainage is a major contributing, and the only preventable, factor in glaucoma development. (jci.org)
  • When the eye's drainage of aqueous humor does not keep up with its production, intraocular pressure is increased and glaucoma is the result. (mtnwestvet.com)
  • Intraocular pressure (IOP) is determined by the amount of aqueous humor secreted, coupled with the rate of clearance from the eye. (aao.org)
  • Apart from supplying the nutrients and removing metabolic wastes from the avascular tissues of the eye, namely, the cornea, trabecular meshwork and the lens, the aqueous humor maintains the optimum intraocular pressure of~15 mmHg that are extremely important to maintain perfect geometry of the ocular structures necessary for optimum light transmission and good vision. (arizona.edu)
  • Intraocular pressure can be kept under control by either reducing the production of aqueous humoror by increasing its outflow. (arizona.edu)
  • Schlemm's canal (SC), a lymphatic-like vessel encircling the anterior portion of the eye, plays a key role in promoting aqueous humor outflow and maintenance of normal intraocular pressure. (jci.org)
  • Aqueous humor is a fluid that provides nutrition to the eye, helps the eye maintain its shape due and provides the intraocular pressure of the eye. (mtnwestvet.com)
  • This is achieved by several mechanisms that facilitate clearance of aqueous humor: inducing contraction of the ciliary body, widening Schlemm's canal, and promoting kinase metaloproteinkinse P42/44 function, which enhances the architecture of the trabecular meshwork. (aao.org)
  • the main exit route of aqueous humor from the eye, including the trabecular meshwork and Schlemm's canal. (zeitereye.com)
  • Excess aqueous humor leaves the anterior chamber, by a pressure dependent way, mainly through a sieve-like structure called the trabecular meshwork located at the junction of the cornea and the sclera. (arizona.edu)
  • In the anterior part of our eye there are two cavities filled with a watery but nutritive fluid called aqueous humor. (arizona.edu)
  • Aqueous humor then sips through the hole at the center of iris, called the pupil, into the anterior chamber. (arizona.edu)
  • My research in the anterior segment of the eye is directed towards reducing the secretion/production of aqueous humor by the ciliary epithelium. (arizona.edu)
  • Aqueous humor is located in the anterior chamber of the eye which is the front most chamber between the cornea and the iris. (mtnwestvet.com)
  • Aqueous humor flows through Schlemm's canal (SC), a lymphatic-like vessel encircling the cornea, and via intercellular spaces of ciliary muscle cells. (northwestern.edu)
  • Your eye continually produces a small amount of aqueous humor while an equal amount flows out of your eye in order to maintain a constant healthy eye pressure. (southern-eye.com)
  • Furthermore, 35 samples of aqueous humor of POAG-HTG patients , 24 PEXG and 29 with senile cataract were treated. (gov.rs)
  • The goal of this study was to characterize histopathological lesions of the liver and kidney of canines, and their relationship with blood and postmortem samples of aqueous humor concentrations of urea, creatinine, proteins and ALT and SAP plasmatic activity. (conicyt.cl)
  • Aqueous humor is contiuously formed into the posterior chamber by the double layer ciliary epithelium that covers the ciliary body. (arizona.edu)
  • Currently the mechanisms and the molecular entities, i.e, the transporter proteins, channels and enzymes associated with the ciliary epithelium and that are responsible for shifting solutes and water from the blood to the posterior chamber in order to produce aqueous humor are not fully understood. (arizona.edu)
  • Aqueous humor (AH) produced by ciliary body epithelium is drained primarily via TM and SC situated at the iridocorneal angle of the eye. (jci.org)
  • Inside the eye is the ciliary body, this structure not only contains the ligaments that hold the lens in place and helps it focus it also produces aqueous humor. (mtnwestvet.com)
  • [2] Moreover, cannabinoids not only act through the CB1 pathway, but also activate COX-2, which in turn increases the presence of prostaglandin E2 (PE2) and melloproteinases-1, -3, and -9, enhancing the outflow of aqueous humor and reducing IOP. (aao.org)
  • Purine nucleotide degradation products have been determined by HPLC in aqueous humor obtained during cataract surgery and from plasma of 22 patients (12 women). (uniroma1.it)
  • To obtain aqueous humor and tear fluid samples during cataract surgery of the hepatitis C virus (HCV)-antibody-positive patients in order to analyze them for HCV RNA and compare these measurements with serum HCV RNA levels. (qxmd.com)
  • aqueous humor hypoxanthine concentrations were lower than those of xanthine and than plasma oxypurine levels. (uniroma1.it)
  • In 8 patients, treated with allopurinol, oxypurinol concentrations in aqueous humor and in plasma were comparable suggesting that oxypurines are transported through the blood-aqueous humor barrier. (uniroma1.it)
  • Determination of uric acid concentrations in human tear fluid, aqueous humour and serum. (qxmd.com)
  • Distribution of genetic polymorphisms for TNF-α -308 G/A and - 863 C/A in DNA samples was examined using PCR-RFLP, the concentrations of circulating TNF-α and HSP 70 in a plasma and concentration of sFas and sFasL in the aqueous humor were measured by commercial ELISA tests. (gov.rs)
  • PAREDES, E. e PEREZ, J. . Histopathological study of canine liver and kidney and their relationship with blood and postmortem aqueous humour samples concentrations of urea, creatinine, proteins and enzymes activities (ALT and SAP). (conicyt.cl)
  • Eye pressure results from a delicate balance between fluid - called the aqueous humor -- entering into and draining out of it. (clayeyecenter.com)
  • a ring of tissue between the iris and the choroid consisting of muscles and blood vessels that changes the shape of the lens and manufactures aqueous humor. (zeitereye.com)
  • The values of urea, creatinine and proteins concentration and ALT and SAP activity were higher in plasma than in aqueous humour, but there was not a correlation between them, with exception of urea (c = 0.99). (conicyt.cl)
  • aqueous humour. (conicyt.cl)
  • Uric acid and the last two were the only compounds detectable in measurable amounts in aqueous humor and in plasma of all patients. (uniroma1.it)
  • Our laboratory is dedicated: (1) in identifying the transport molecules and enzymes required for aqueous humor secretion, (2) in characterizing these molecules functionally and (3) in identifying and characterizing the signal transduction mechanisms that regulate the functions of these molecules and (4) in pharmacological regulation of these molecules and /or the associated signal transduction mechanisms. (arizona.edu)
  • Log10 HCV RNA levels were found to be 6.00 ± 1.06 IU/mL in serum, 2.76 ± 0.36 IU/mL in the aqueous humor, and 1.91 ± 0.93 IU/mL in tear fluid. (qxmd.com)
  • We have observed that, viral RNA was detected in the aqueous humor, while not in serum in one case, whereas viral RNA was detected in tear fluid but not in serum in another case. (qxmd.com)
  • Although viral load detected in aqueous humor and tear fluid samples was considerably lower compared to the serum samples, it can still be important in terms of infectivity. (qxmd.com)
  • The aqueous humor is a clear fluid that maintains the integrity of the eye. (aao.org)
  • levels were also measured in the aqueous humor samples by an ELISA method. (ktu.edu.tr)
  • Hypoxanthine and xanthine levels in human aqueous humor from cataractous eyes. (uniroma1.it)
  • Moxifloxacin Concentration and Proteomic Analysis of Aqueous Humor in " by David M. Hinkle, Nicole A. Kruh-Garcia et al. (umassmed.edu)
  • Distinguish, differentiate, compare and explain what is the main difference between aqueous and vitreous humor. (steadyrun.com)
  • 1. Aqueous humor occurs in aqueous chamber whereas vitreous humor occurs in vitreous chamber. (steadyrun.com)
  • The vitreous humor (or vitreous body) is the gelatinous goop that fills the inside of your eyeball. (mentalfloss.com)
  • The vitreous humor, which lies against the retina, makes up a large part of the eye. (verywellhealth.com)
  • As we age, the vitreous humor becomes less firm. (verywellhealth.com)
  • If the force of the pulling becomes strong enough, the vitreous humor may actually separate from the retina. (verywellhealth.com)
  • The vitreous chamber is the space in the eye occupied by vitreous humor. (wikipedia.org)
  • This chamber is filled with a thick, clear gel-like substance called the vitreous humor (also vitreous body). (wikipedia.org)
  • The objective of this proposal is to develop a surrogate tumor biopsy for retinoblastoma using the aqueous humor, which is the clear fluid in a separate part of the eye from where the tumor forms. (grantome.com)
  • In the present study, LGR5 was compared in human aqueous humor (AH) between normal control and patients with PDR to confirm the relationship between LGR5 and PDR. (hanyang.ac.kr)
  • Furthermore we could find noticeable correlations between clinical characteristics and immune mediator concentrations in aqueous humor. (fu-berlin.de)
  • These findings suggest that aqueous humor can serve as a surrogate tumor biopsy for analyses of tumor-derived DNA in retinoblastoma eyes. (aao.org)
  • Use of the aqueous humor as a surrogate tumor biopsy holds tremendous potential, from directly impacting the way we manage retinoblastoma patients, to ultimately allowing for the development of personalized medicine for this blinding childhood cancer. (grantome.com)
  • This study will compare aqueous humor dynamics in adults with primary open angle glaucoma that receive Selective Laser Trabeculoplasty (SLT). (clinicaltrials.gov)
  • The effect of SLT on the aqueous humor dynamics is currently unknown. (clinicaltrials.gov)
  • This study will determine the changes in aqueous humor dynamics produced by SLT that lead to its IOP lowering effect. (clinicaltrials.gov)
  • It presents a timely update to current knowledge of the molecular transport mechanisms which underlie aqueous humor dynamics. (textbookx.com)
  • Effects of exogenous prostaglandins on aqueous humor dynamics and blood-aqueous barrier function. (semanticscholar.org)
  • Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension. (pubfacts.com)
  • This study evaluates aqueous humor dynamics in rhesus monkeys from the University of Florida inbred colony with ocular normotension and naturally occurring ocular hypertension. (pubfacts.com)
  • We have shown previously that transplantation of induced pluripotent stem cell (iPSC) derived TM cells restores aqueous humor dynamics in young transgenic mice expressing a pathogenic form of human myocilin (Tg-MYOCY437H). (tuckerlaboratory.org)
  • The iris, cornea, and lens are bathed in a liquid called the aqueous humor, which is somewhat similar to plasma. (encyclopedia.com)
  • an inner diameter of between 0.3 mm and 0.4 mm and sufficient length to position the anterior end in the anterior chamber of the eye and the rear end having a size which fits within an area covered by a perimeter of the cover, located in the intrascleral space for drainage of the aqueous humor. (google.com)
  • It is called "open-angle" because the angle between the iris and the cornea is open, allowing drainage of the aqueous humor. (encyclopedia.com)
  • The purpose of this study is to evaluate the 5-HT and 5-HIAA (5-hydroxiindolacetic acid) levels in the aqueous humor of patients with primary open-angle glaucoma (POAG). (molvis.org)
  • Aqueous humor was obtained from five human donors diagnosed with primary open angle glaucoma (POAG) and five age- and sex-matched controls undergoing cataract surgery. (physiciansweekly.com)
  • The identification of key cytokines, which function by increasing the permeability properties of cellular barriers, will open up a new therapeutic approach to treat glaucoma by promoting the outflow of aqueous through the trabecular or conventional aqueous outflow pathway. (grantome.com)
  • Aqueous humor biopsy may be an improvement over existing methods, as it could require less advanced technical skills and carry a lower risk of causing ocular or systemic comorbidity. (aao.org)
  • Alex Huang, MD, sheds light on the importance of understanding aqueous outflow at a fundamental level and discusses aqueous humor outflow imaging methods. (eyetube.net)
  • Methods 40 consecutive cases of TRC with a positive aqueous humour (AH) tap for toxoplasmosis were retrospectively included. (ovid.com)
  • The invention provides minimally invasive microsurgical tools and methods to form an aqueous humor shunt or bypass for the treatment of glaucoma. (google.com)
  • Methods: Aqueous humor samples were collected during keratoplasty of 12 PBK patients, as well as during phacoemulsification surgery of 18 control patients. (elsevier.com)
  • METHODS: Multiple reactions monitoring mass spectrometry quantified the aqueous concentration of moxifloxacin in the affected individual. (umassmed.edu)
  • The surgery involves removing a small piece of the white, outer shell of the eye, to create a channel through which the aqueous humor fluid can flow. (freethesaurus.com)
  • show that the production of the ABTS radical cation in the presence of human aqueous humor follows lag phase kinetics consistent with this fluid acting as a sacrificial antioxidant. (freethesaurus.com)
  • 2. Aqueous humor is a watery fluid while vitreous is a jelly-like substance. (steadyrun.com)
  • These fluids are humors in name only, and are necessary to eye function: The aqueous humor is a clear fluid that brings nutrients to the lens area of your eye, so that you're not-you know-looking at blood all the time. (mentalfloss.com)
  • Aqueous humor is a clear, watery fluid, contained in two chambers behind the cornea, that helps to bring nutrients to the eye tissues. (visionaware.org)
  • As it circulates, the aqueous fluid flows to the front part of the eye, where it is drained by the trabecular meshwork , a sponge-like filtering system located where the cornea and iris meet. (visionaware.org)
  • After draining through the trabecular meshwork, the aqueous fluid then passes through a small duct, called the canal of Schlemm , and is absorbed into the bloodstream. (visionaware.org)
  • The health of your eye depends upon a continuous process of production, flow, and drainage of this aqueous fluid. (visionaware.org)
  • Learn what aqueous humor means and how the flow of this fluid can cause glaucoma disease. (brightfocus.org)
  • The aqueous humor is a clear, watery fluid located behind the cornea. (verywellhealth.com)
  • Problems with the aqueous fluid can lead to issues involving the eye's pressure, such as glaucoma . (verywellhealth.com)
  • In narrow-angle glaucoma, the angle where aqueous fluid drainage occurs is narrow, and therefore may drain slowly or may be at risk of becoming closed. (encyclopedia.com)
  • Lidocaine concentration was measured in aqueous humor samples taken before surgery. (diva-portal.org)
  • RESULTS: With 3 drops, aqueous lidocaine concentration was 1.4 micrograms/mL +/- 0.5 (SD) and with 6 drops, 4.3 +/- 1.5 micrograms/mL (P = .0015). (diva-portal.org)
  • The purpose of this study is to obtain and assay human aqueous samples following pre-operative dosing with 0.1% Brimonidine Purite™ (pH 7.8) or with 0.15% Brimonidine Purite® (pH 7.2) from patients undergoing routine cataract surgery in order to evaluate the aqueous concentration of the two formulations. (clinicaltrials.gov)
  • All aqueous humor (AqH) samples were tested for total protein concentration, ability to suppress in vitro T-cell activation, and total TGF-β 2 content. (egms.de)
  • 0.3% gatifloxacin ophthalmic gel application produced highest aqueous humor drug concentration, maintained the longest time, had the best penetration and bioavailability. (medsci.org)
  • Cell number and protein concentration in the aqueous humor begin to increase 6 hours after the endotoxin injection and reach a peak at 24 hours before gradually decreasing. (freethesaurus.com)
  • The concentration of TF in aqueous humor (AH) was compared with the grade of DR. The concentration of TF in AH was also compared with duration of diabetes, renal function, and blood glucose control. (elsevier.com)
  • PURPOSE: The aim was to report the aqueous humor moxifloxacin concentration and proteome profile of an individual with bilateral uveitis-like syndrome with pigment dispersion. (umassmed.edu)
  • A recent publication focuses on the flow of aqueous humor in the posterior chamber [ 9 ]. (hindawi.com)
  • The levels of 48 cytokines in aqueous humor were detected by multiplex analysis with antibody-coupled magnetic beads. (researchsquare.com)
  • Aqueous humor cytokine profiling in patients with wet AMD. (nih.gov)
  • The research was to evaluate cytokine profile in aqueous humor of congenital cataract with PCD to search the pathogeny of PCD. (arvojournals.org)
  • Conclusion: Cytokine expression pattern in the aqueous humor, in contrast to that in serum, may reflect intraocular immune reactions during active inflammation in patients with AAU. (eurekaselect.com)
  • To provide clarity regarding the treatment and prognosis of idiopathic macular holes, specifically regarding the levels of cytokines in affected patients, this study examined and analyzed multiple cytokine levels in aqueous humor from patients with idiopathic macular holes. (researchsquare.com)
  • There were significant differences in aqueous humor cytokine levels between patients with idiopathic macular holes and patients in the cataract control group. (researchsquare.com)
  • Patients with idiopathic macular holes showed significant variation in aqueous humor immune response after the onset of hole formation, including the recruitment of immune cells and regulation of cytokine expression. (researchsquare.com)
  • Our findings also suggest that it is not appropriate to use patients with macular holes as the control group in studies of aqueous humor cytokine levels in ophthalmic diseases. (researchsquare.com)
  • To investigate the penetration of 0.3% gatifloxacin ophthalmic gel, 0.3% gatifloxacin ophthalmic solution and 0.5% levofloxacin ophthalmic solution into aqueous humor after topical application. (medsci.org)
  • Assays of immune privilege markers in AqH reveal that mean TGF-β 2 content is abnormally low in patients coming to PK due to the high risk cases and that PK surgery results in a sustained loss of integrity of the blood-aqueous barrier. (egms.de)
  • Dr. Huang comments on how aqueous angiography facilitates surgeons' ability to place surgeries in customized locations for better intraocular pressure-lowering results. (eyetube.net)
  • Intraocular pressure in the sitting position changes minimally during sleep, although aqueous humor flow decreases by 50% or more at night. (arvojournals.org)
  • Glaucoma is a disease condition of the eye in which increased intraocular pressure (IOP) is created by dysfunction in the drainage mechanism for the aqueous humor. (google.com)
  • The compound has demonstrated the ability to lower intraocular pressure by stimulating aqueous humor outflow via trabecular meshwork through an activation of adenosine A2a receptor. (freethesaurus.com)
  • When the aqueous humour does not adequately drain from the eye, intraocular pressure can rise and loss of vision can result. (britannica.com)
  • During the night, intraocular pressure may not decrease despite the slower production of aqueous humour. (wikipedia.org)
  • We describe a patient with serologically proven visceral toxocariasis who had a granulomatous lesion in the iris, small rod-like lesions in the retina, and in whom Toxocara -specific antibodies were also demonstrated in the aqueous humor. (ajtmh.org)
  • Product Details for The Eye's Aqueous Humor: From Secretion to Glaucoma by Civan, Mortimer M. (textbookx.com)
  • This study finds that aqueous humor from retinoblastoma eyes contains tumor-derived DNA that can be analyzed as an alternative to tissue biopsy. (aao.org)
  • therefore, this study aimed to identify cfDNA in the aqueous humor (AH) of retinoblastoma eyes and correlate somatic chromosomal copy-number alterations (SCNA) with clinical outcomes, specifically eye salvage. (aacrjournals.org)
  • Development of a surrogate liquid biopsy from the aqueous humor in retinoblastoma eyes. (grantome.com)
  • The objective of this proposal is to evaluate tumor-specific genetic markers in the aqueous humor, which is safe to extract even in advanced retinoblastoma eyes. (grantome.com)
  • MIGS offer a small wound, safe, and fast surgical approach to enhance aqueous humor outflow (AHO) drainage. (omicsonline.org)
  • In addition, monocytes have been shown to enhance aqueous outflow in an animal model in vivo and also to increase the permeability of cultured Schlemm's canal endothelial (SCE) cells in vitro. (grantome.com)
  • Notrox has vast experience in handling human aqueous humor sample analysis by liquid chromatography (LC)and mass spectrometry (MS). The company has conducted bioequivalance studies in post cataract surgery for generic products. (pharmaceutical-technology.com)
  • Lipids were extracted from aqueous humor by solid phase exaction, and analyzed via liquid chromatography tandem mass spectrometry (LC-MS/MS, Thermo Scientific) in negative-ion mode. (arvojournals.org)
  • Quantitative proteome analysis of the aqueous humor by hyper reaction monitoring mass spectrometry (HRM-MS) based on SWATH technology was performed. (physiciansweekly.com)
  • Changes to the Aqueous Humor Proteome during Glaucoma. (physiciansweekly.com)
  • To investigate the aqueous humor proteome in patients with glaucoma and a control group. (physiciansweekly.com)
  • Glaucoma leads to profound changes to the aqueous humor proteome consistent with an altered metabolic state, an inflammatory response and impaired antioxidant defense. (physiciansweekly.com)
  • One-third of the proteins were identified by significantly lower spectral counts in the aqueous of the individual with moxifloxacin associated uveitis compared to the unaffected control. (umassmed.edu)
  • Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma. (tuckerlaboratory.org)
  • Undiluted aqueous humor samples were collected from 10 patients who underwent either elective cataract surgery and/or non-elective glaucoma surgery. (arvojournals.org)
  • Aqueous samples were collected at different time points after the last drop. (medsci.org)
  • To investigate aqueous humor nitric oxide (NO) levels in patients with branch retinal vein occlusion (BRVO) and central retinal vein occlusion (CRVO) and to compare these with age-matched controls. (irjo.org)
  • To investigate the aqueous humor levels of soluble Fas (sFas) and Fas-Ligand (sFasL) in glaucomatous patients. (ac.ir)
  • Evaluation of aqueous humor demonstrated tumor-derived, cell-free DNA and regions of chromosomal gains and losses, representing changes in the tumor. (aao.org)
  • Our preliminary data from evaluation of the aqueous revealed that tumor-derived cell-free DNA is present and whole genome sequencing demonstrates a profile of chromosomal gains and losses that corroborate changes in the tumor. (grantome.com)
  • The lens influences aqueous humor levels of transforming growth factor-beta 2. (biomedsearch.com)
  • The humor plays a crucial role in supporting the posterior side of the lens. (wikipedia.org)
  • Aqueous humor specimens were obtained within 21 days of diagnosis. (irjo.org)
  • The levels of IL-17a in aqueous humor correlated significantly with disease activity in patients with idiopathic AAU, while the level of IFN-γ in aqueous humor correlated significantly with disease activity in patients with HLA-B27 associated AAU. (eurekaselect.com)
  • Of the 87 proteins, 34 were significantly upregulated, whereas 53 proteins were downregulated in the aqueous humor from glaucoma patients compared to controls. (physiciansweekly.com)
  • Functional assessment focuses on visualizing AHO itself through a variety of non-real-time and real-time techniques such as aqueous angiography. (omicsonline.org)
  • To determine if factors present in the aqueous humor (AH) protect the corneal endothelium from apoptosis. (elsevier.com)
  • Elevated levels of inflammation-related chemokines, including CXCL10, CCL14, CXCL16, CXCL7, and CCL22, in the aqueous humor of AMD patients may suggest a pathogenic role for inflammation. (nih.gov)
  • Surprisingly, aqueous humor from aphakic rabbit eyes contained significantly higher levels of TGF-beta 2 than their contralateral phakic controls. (biomedsearch.com)
  • Furthermore, aqueous humor from canine eyes with cataracts also contained significantly higher levels of TGF-beta 2 than normal eyes. (biomedsearch.com)
  • Levels of various inflammation-related cytokines in the aqueous humor of using multiplex immunoassay. (arvojournals.org)
  • Higher preoperative levels of TGFβ2, IL-6, VEGF in aqueous humor were associated with posterior capsule defect, which indicated the inflammation state in congenital cataract with posterior capsule defect. (arvojournals.org)
  • Expression levels of 87 proteins were found to be different between glaucomatous and control aqueous humor. (physiciansweekly.com)
  • Foscarnet induction treatment is highly effective in suppressing or reducing DNA levels in both blood leukocytes and aqueous humor. (asm.org)
  • Measurement of physiologic glucose levels using Raman spectroscopy in a rabbit aqueous humor model. (freethesaurus.com)
  • RESULTS: Moxifloxacin was present at higher than expected levels in aqueous humor 18 days following oral administration. (umassmed.edu)
  • Aqueous humor glucose levels ranged from 37 to 323 mg/dL. (sae.org)
  • Mohamed Awad , Ocular penetration of cortisone derivatives into the aqueous humor after subconjunctival injection, Bull. (who.int)
  • Extracellular microRNAs (miRNAs) in aqueous humor were suggested to have a role in transcellular signaling and may serve as disease biomarkers. (nih.gov)
  • Compared with the control group, the aqueous humor in wet AMD patients showed a significantly higher expression of CXCL10 (p=0.004), CCL14 (p=0.002), CXCL16 (p=0.013), CXCL7 (p=0.033), and CCL22 (p=0.037), while growth-related oncogene (GRO) was significantly decreased in the wet AMD patients (p=0.001). (nih.gov)
  • Polymerase chain reaction for the detection of Toxoplasma gondii within aqueous humor of experimentally-inoculated cats. (unboundmedicine.com)
  • TY - JOUR T1 - Polymerase chain reaction for the detection of Toxoplasma gondii within aqueous humor of experimentally-inoculated cats. (unboundmedicine.com)
  • Ocular infection with Toxoplasma gondii (T. gondii) leads to the production of antibodies, cytokines and chemokines as part of the immune response in the affected person's aqueous humor. (fu-berlin.de)
  • Aim 2 is to identify the specific RB1 mutation(s) that underlie tumorigenesis from the aqueous humor. (grantome.com)