Aquaporins
Aquaporin 1
Aquaporin 5
Aquaporin 5 is a water-specific channel protein that is expressed primarily in alveolar, tracheal, and upper bronchial EPITHELIUM. It plays an important role in maintaining water HOMEOSTASIS in the LUNGS and may also regulate release of SALIVA and TEARS in the SALIVARY GLANDS and the LACRIMAL GLAND.
Aquaporin 4
Water
Aquaporin 6
Aquaglyceroporins
Aquaporin 2
Mercuric Chloride
Osmosis
Plant Transpiration
Water-Electrolyte Balance
Plant Proteins
Permeability
Glycerol
Kidney Concentrating Ability
Biological Transport
Cistaceae
Plant Roots
Tulipa
Cell Membrane Permeability
Blood Group Antigens
Gene Expression Regulation, Plant
Trichomes
Calotropis
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Osmotic Pressure
Amino Acid Sequence
4-Chloromercuribenzenesulfonate
Cell Membrane
Ion Channels
Plant Leaves
Acoustic Maculae
Pulvinus
Spinacia oleracea
Exocrine Glands
Polyuria
Tephritidae
Kidney Tubules, Collecting
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Xenopus laevis
Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. (1/1459)
It has been controversial whether high water permeability in the thin descending limb of Henle (TDLH) is required for formation of a concentrated urine by the kidney. Freeze-fracture electron microscopy (FFEM) of rat TDLH has shown an exceptionally high density of intramembrane particles (IMPs), which were proposed to consist of tetramers of aquaporin-1 (AQP1) water channels. In this study, transepithelial osmotic water permeability (Pf) was measured in isolated perfused segments (0.5-1 mm) of TDLH in wild-type (+/+), AQP1 heterozygous (+/-), and AQP1 null (-/-) mice. Pf was measured at 37 degrees C using a 100 mM bath-to-lumen osmotic gradient of raffinose, and fluorescein isothiocyanate (FITC)-dextran as the luminal volume marker. Pf was (in cm/s): 0.26 +/- 0.02 ([+/+]; SE, n = 9 tubules), 0.21 +/- 0.01 ([+/-]; n = 12), and 0.031 +/- 0.007 ([-/-]; n = 6) (P < 0.02, [+/+] vs. [+/-]; P < 0.0001, [+/+] vs. [-/-]). FFEM of kidney medulla showed remarkably fewer IMPs in TDLH from (-/-) vs. (+/+) and (+/-) mice. IMP densities were (in microm-2, SD, 5-12 micrographs): 5,880 +/- 238 (+/+); 5,780 +/- 450 (+/-); and 877 +/- 420 (-/-). IMP size distribution analysis revealed mean IMP diameters of 8.4 nm ([+/+] and [+/-]) and 5.2 nm ([-/-]). These results demonstrate that AQP1 is the principal water channel in TDLH and support the view that osmotic equilibration along TDLH by water transport plays a key role in the renal countercurrent concentrating mechanism. The similar Pf and AQP1 expression in TDLH of (+/+) and (+/-) mice was an unexpected finding that probably accounts for the unimpaired urinary concentrating ability in (+/-) mice. (+info)Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. (2/1459)
The mammalian lung expresses water channel aquaporin-1 (AQP1) in microvascular endothelia and aquaporin-4 (AQP4) in airway epithelia. To test whether these water channels facilitate fluid movement between airspace, interstitial, and capillary compartments, we measured passive and active fluid transport in AQP1 and AQP4 knockout mice. Airspace-capillary osmotic water permeability (Pf) was measured in isolated perfused lungs by a pleural surface fluorescence method. Pf was remarkably reduced in AQP1 (-/-) mice (measured in cm/s x 0.001, SE, n = 5-10: 17 +/- 2 [+/+]; 6.6 +/- 0.6 AQP1 [+/-]; 1.7 +/- 0.3 AQP1 [-/-]; 12 +/- 1 AQP4 [-/-]). Microvascular endothelial water permeability, measured by a related pleural surface fluorescence method in which the airspace was filled with inert perfluorocarbon, was reduced more than 10-fold in AQP1 (-/-) vs. (+/+) mice. Hydrostatically induced lung interstitial and alveolar edema was measured by a gravimetric method and by direct measurement of extravascular lung water. Both approaches indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in response to a 5- to 10-cm H2O increase in pulmonary artery pressure for five minutes. Active, near-isosmolar alveolar fluid absorption (Jv) was measured in in situ perfused lungs using 125I-albumin as an airspace fluid volume marker. Jv (measured in percent fluid uptake at 30 min, n = 5) in (+/+) mice was 6.0 +/- 0.6 (37 degrees C), increased to 16 +/- 1 by beta-agonists, and inhibited to less than 2.0 by amiloride, ouabain, or cooling to 23 degrees C. Jv (with isoproterenol) was not affected by aquaporin deletion (18.9 +/- 2.2 [+/+]; 16.4 +/- 1.5 AQP1 [-/-]; 16.3 +/- 1.7 AQP4 [-/-]). These results indicate that osmotically driven water transport across microvessels in adult lung occurs by a transcellular route through AQP1 water channels and that the microvascular endothelium is a significant barrier for airspace-capillary osmotic water transport. AQP1 facilitates hydrostatically driven lung edema but is not required for active near-isosmolar absorption of alveolar fluid. (+info)Switch from an aquaporin to a glycerol channel by two amino acids substitution. (3/1459)
The MIP (major intrinsic protein) proteins constitute a channel family of currently 150 members that have been identified in cell membranes of organisms ranging from bacteria to man. Among these proteins, two functionally distinct subgroups are characterized: aquaporins that allow specific water transfer and glycerol channels that are involved in glycerol and small neutral solutes transport. Since the flow of small molecules across cell membranes is vital for every living organism, the study of such proteins is of particular interest. For instance, aquaporins located in kidney cell membranes are responsible for reabsorption of 150 liters of water/day in adult human. To understand the molecular mechanisms of solute transport specificity, we analyzed mutant aquaporins in which highly conserved residues have been substituted by amino acids located at the same positions in glycerol channels. Here, we show that substitution of a tyrosine and a tryptophan by a proline and a leucine, respectively, in the sixth transmembrane helix of an aquaporin leads to a switch in the selectivity of the channel, from water to glycerol. (+info)Modifications to rat lens major intrinsic protein in selenite-induced cataract. (4/1459)
PURPOSE: To identify modifications to rat lens major intrinsic protein (MIP) isolated from selenite-induced cataract and to determine whether m-calpain (EC 3.4.22.17) is responsible for cleavage of MIP during cataractogenesis. METHODS: Cataracts were induced in rats by a single injection of sodium selenite. Control and cataract lenses were harvested on day 16 and dissected into cortical and nuclear regions. Membranes were washed with urea buffer followed by NaOH. The protein was reduced/alkylated, delipidated, and cleaved with cyanogen bromide (CNBr). Cleavage products were fractionated by high-performance liquid chromatography (HPLC), and peptides were characterized by mass spectrometry and tandem mass spectrometry. MIP cleavage by m-calpain was carried out by incubation with purified enzyme, and peptides released from the membrane were analyzed by Edman sequencing. RESULTS: The intact C terminus, observed in the control nuclear and cataractous cortical membranes, was not observed in the cataractous nuclear membranes. Mass spectrometric analysis revealed heterogeneous cleavage of the C terminus of MIP in control and cataract nuclear regions. The major site of cleavage was between residues 238 and 239, corresponding to the major site of in vitro cleavage by m-calpain. However, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and mass spectrometric analysis indicated that in vivo proteolysis during cataract formation also included sites closer to the C terminus not produced by m-calpain in vitro. Evidence for heterogeneous N-terminal cleavage was also observed at low levels with no differences between control and cataractous lenses. The major site of phosphorylation was determined to be at serine 235. CONCLUSIONS: Specific sites of MIP N- and C-terminal cleavage in selenite-induced cataractous lenses were identified. The heterogeneous cleavage pattern observed suggests that m-calpain is not the sole enzyme involved in MIP C-terminal processing in rat lens nuclei. (+info)Transport of fluid by lens epithelium. (5/1459)
We report for the first time that cultured lens epithelial cell layers and rabbit lenses in vitro transport fluid. Layers of the alphaTN4 mouse cell line and bovine cell cultures were grown to confluence on permeable membrane inserts. Fluid movement across cultured layers and excised rabbit lenses was determined by volume clamp (37 degrees C). Cultured layers transported fluid from their basal to their apical sides against a pressure head of 3 cmH2O. Rates were (in microliter. h-1. cm-2) 3.3 +/- 0.3 for alphaTN4 cells (n = 27) and 4.7 +/- 1.0 for bovine layers (n = 6). Quinidine, a blocker of K+ channels, and p-chloromercuribenzenesulfonate and HgCl2, inhibitors of aquaporins, inhibited fluid transport. Rabbit lenses transported fluid from their anterior to their posterior sides against a 2.5-cmH2O pressure head at 10.3 +/- 0.62 microliter. h-1. lens-1 (n = 5) and along the same pressure head at 12.5 +/- 1.1 microliter. h-1. lens-1 (n = 6). We calculate that this flow could wash the lens extracellular space by convection about once every 2 h and therefore might contribute to lens homeostasis and transparency. (+info)Expression and localization of aquaporins in rat gastrointestinal tract. (6/1459)
A family of water-selective channels, aquaporins (AQP), has been demonstrated in various organs and tissues. However, the localization and expression of the AQP family members in the gastrointestinal tract have not been entirely elucidated. This study aimed to demonstrate the expression and distribution of several types of the AQP family and to speculate on their role in water transport in the rat gastrointestinal tract. By RNase protection assay, expression of AQP1-5 and AQP8 was examined in various portions through the gastrointestinal tract. AQP1 and AQP3 mRNAs were diffusely expressed from esophagus to colon, and their expression was relatively intense in the small intestine and colon. In contrast, AQP4 mRNA was selectively expressed in the stomach and small intestine and AQP8 mRNA in the jejunum and colon. Immunohistochemistry and in situ hybridization demonstrated cellular localization of these AQP in these portions. AQP1 was localized on endothelial cells of lymphatic vessels in the submucosa and lamina propria throughout the gastrointestinal tract. AQP3 was detected on the circumferential plasma membranes of stratified squamous epithelial cells in the esophagus and basolateral membranes of cardiac gland epithelia in the lower stomach and of surface columnar epithelia in the colon. However, AQP3 was not apparently detected in the small intestine. AQP4 was present on the basolateral membrane of the parietal cells in the lower stomach and selectively in the basolateral membranes of deep intestinal gland cells in the small intestine. AQP8 mRNA expression was demonstrated in the absorptive columnar epithelial cells of the jejunum and colon by in situ hybridization. These findings may indicate that water crosses the epithelial layer through these water channels, suggesting a possible role of the transcellular route for water intake or outlet in the gastrointestinal tract. (+info)Long-term regulation of aquaporins in the kidney. (7/1459)
The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct water permeability, in particular, has advanced very rapidly since the identification and characterization of aquaporin-2 (AQP2) in 1993. One of the more surprising findings has been the dramatic long-term changes that are seen in the abundance of this protein, as well as the recognition that these changes represent a way of modulating the acute antidiuretic effects of vasopressin. Furthermore, such changes seem to be of etiological and pathological significance in a number of clinical disorders of water balance. This review focuses on the various conditions in which AQP2 expression is altered (either increased or decreased) and on what this can tell us about the signals and mechanisms controlling these changes. Ultimately, this may be of great value in the clinical management of water balance disorders. Evidence is also now beginning to emerge that there are similar changes in the expression of other renal aquaporins, which had previously been thought to provide an essentially constitutive water permeability pathway, suggesting that they too should be considered as regulatory factors in the control of body water balance. (+info)Physiology and pathophysiology of renal aquaporins. (8/1459)
The discovery of aquaporin membrane water channels by Agre and coworkers answered a long-standing biophysical question of how water specifically crosses biologic membranes, and provided insight, at the molecular level, into the fundamental physiology of water balance and the pathophysiology of water balance disorders. Of nine aquaporin isoforms, at least six are known to be present in the kidney at distinct sites along the nephron and collecting duct. Aquaporin-1 (AQP1) is extremely abundant in the proximal tubule and descending thin limb, where it appears to provide the chief route for proximal nephron water reabsorption. AQP2 is abundant in the collecting duct principal cells and is the chief target for vasopressin to regulate collecting duct water reabsorption. Acute regulation involves vasopressin-regulated trafficking of AQP2 between an intracellular reservoir and the apical plasma membrane. In addition, AQP2 is involved in chronic/adaptational regulation of body water balance achieved through regulation of AQP2 expression. Importantly, multiple studies have now identified a critical role of AQP2 in several inherited and acquired water balance disorders. This concerns inherited forms of nephrogenic diabetes insipidus and several, much more common acquired types of nephrogenic diabetes insipidus where AQP2 expression and/or targeting are affected. Conversely, AQP2 expression and targeting appear to be increased in some conditions with water retention such as pregnancy and congestive heart failure. AQP3 and AQP4 are basolateral water channels located in the kidney collecting duct, and AQP6 and AQP7 appear to be expressed at lower abundance at several sites including the proximal tubule. This review focuses mainly on the role of AQP2 in water balance regulation and in the pathophysiology of water balance disorders. (+info)
Integrative sequence and tissue expression profiling of chicken and mammalian aquaporins | BMC Genomics | Full Text
Aquaporin water channels - From atomic structure to clinical medicine<...
Anti-PIP2-7 | plasma membrane aquaporin antibodies
Effects of exogenous 5-aminolevulinic acid on PIP1 and NIP aquaporin gene expression in seedlings of cucumber cultivars...
The zebrafish genome encodes the largest vertebrate repertoire of functional aquaporins with dual paralogy and substrate...
Aquaporins in the kidney: from molecules to medicine. - Aquaporin and water channels
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B<...
Aquaporin expression and function in human pluripotent stem cell -derived retinal pigment epithelial cells | IOVS | ARVO...
Funktionelle Charakterisierung der Arabidopsis thaliana Aquaporine AtPIP1;2 und AtPIP2;3
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TUprints
Open Access Journals
A PIP1 Aquaporin contributes to hydrostatic pressure-induced water transport in both the root and rosette of Arabidopsis -...
AQP5 - Wikipedia
The Plasma Membrane of Arabidopsis thaliana Contains a Mercury-Insensitive Aquaporin That Is a Homolog of the Tonoplast Water...
Aquaporin water channels in liver: Their significance in bile formation - Marinelli - 2003 - Hepatology - Wiley Online Library
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DIGITAL.CSIC: Molecular pathways during marine fish egg hydration: the role of aquaporins
PLOS ONE: A Small Molecule Inhibitor Partitions Two Distinct Pathways for Trafficking of Tonoplast Intrinsic Proteins in...
Aquaporins at a glance | Journal of Cell Science
High resolution AFM topographs of the Escherichia coli water channel aquaporin Z | The EMBO Journal
Aquaporin water channels in liver: their significance in bile formation. | Semantic Scholar
IJMS | Free Full-Text | Fragment Screening of Human Aquaporin 1
Cells | Free Full-Text | Insight into Salivary Gland Aquaporins
Aquaporin-8
Aquaporin membrane protein, molecular model - Stock Image C035/5236 - Science Photo Library
Aquaporins in health and disease: new molecular targets for drug discovery
- Aalborg Universitets forskningsportal
Ebook 978-3319493930 Plant Aquaporins: From Transport to Signaling (Signaling and Communication i
Mempro⢠Cell-Free Major Intrinsic Protein (MIP)/FNT Superfamily Production - Creative Biostructure
Identification of a novel aquaporin, AQP12, expressed in pancreatic acinar cells<...
Molecular Basis of pH and Ca2+ Regulation of Aquaporin Water Permeability | JGP
Molecular Basis of pH and Ca2+ Regulation of Aquaporin Water Permeability | Journal of General Physiology | Rockefeller...
Cloning, functional analysis and cell localization of a kidney proximal tubule water transporter homologous to CHIP28. | JCB
US Patent # 5,788,407. Paving method of water-permeable concrete - Patents.com
dna testing kits for paternity - Aquaporin and water channels
Aquaporins and the respiratory system: Advice for a lung investigator<...
Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated...
One protein, two channels: Scientists explain mechanism in aquaporins
Blar i Department of Biological Sciences pƄ tidsskrift Cells
RNAiDB Tree View
The role of putative phosphorylation sites in the targeting and shuttling of the aquaporin-2 water channel. - Physiomics
Recent Articles | Aquaporins And Culture | The Scientist MagazineĀ®| Page 5
Recent Articles | Aquaporins And Evolution | The Scientist MagazineĀ®| Page 6
Aquaporins in Health and Disease by Graca Soveral, Soren Nielsen, Angela Casini - Access IT Systems Books
Analysis of aquaporins from the euryhaline barnacle Balanus improvisus reveals differential expression in response to changes...
Brazil Flavored and Functional Water Market: Decline in Demand for Sugar-sweetened Carbonated Beverages to Ensure Steady Growth...
Brazil Flavored and Functional Water Market: Decline in Demand for Sugar-sweetened Carbonated Beverages to Ensure Steady Growth...
AQP4 knockout impairs proliferation, migration and neuronal differentiation of adult neural stem cells | Journal of Cell Science
Genome Wide Identification, Phylogeny, and Expression of Aquaporin Genes in Common Carp (Cyprinus carpio)
TIP5;1 is an aquaporin specifically targeted to pollen mitochondria and is probably involved in nitrogen remobilization in...
Genome-wide identification, structure characterization, and expression pattern profiling of aquaporin gene family in cucumber |...
Mitochondrial swelling assay (PTP opening): post #1
Increasing gene dosage greatly enhances recombinant expression of aquaporins in Pichia pastoris | BMC Biotechnology | Full Text
Identification of key residues involved in Si transport by the aquaglyceroporins | Journal of General Physiology | Rockefeller...
Sucrose-induced Receptor Kinase 1 is Modulated by an Interacting Kinase with Short Extracellular Domain | Molecular & Cellular...
Protein Interactions
Conditional osmotic stress in yeast: a system to study transport through aquaglyceroporins and osmostress signaling<...
Science
A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial...
Structure of a Nobel-prize winning molecule: Aquaporin
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An experimental study on water transport through the membrane of a PEFC operating in the dead-end mode<...
Topic 11.3: The Kidney and Osmoregulation - AMAZING WORLD OF SCIENCE WITH MR. GREEN
Prof R A Quinlan - Durham University
AQP4 role in renal K+ transport
Publications | Max Planck Institute for Biophysical Chemistry
Vasopressin : Quiz (The Full Wiki)
Aqp1 polyclonal antibody (ATTO 655) - (PAB28844) - Products - Abnova
Download Moderner Flughafenbau: Entwurf, Dimensionierung Und Bauausführung Von Landebahnen Und Sonstigen Verkehrsflächen 1956
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Astrogliosis
Zador, Zsolt; Stiver, Shirley; Wang, Vincent; Manley, Geoffrey T. (2009). "Role of Aquaporin-4 in Cerebral Edema and Stroke". ... In Beitz, Eric (ed.). Aquaporins. Handbook of Experimental Pharmacology. 190. pp. 159-70. doi:10.1007/978-3-540-79885-9_7. ISBN ...
Major intrinsic proteins
The MIP superfamily includes three subfamilies: aquaporins, aquaglyceroporins and S-aquaporins. The aquaporins (AQPs) are water ... Aquaporin-1 (Aqp1) from the human red blood cell has been solved by electron crystallography to 3.8 Ć
resolution (PDB: 1FQYā). ... Aquaporins generally have the NPA motif in both halves, the glycerol facilitators generally have an NPA motif in the first ... Roles of aquaporins in human cancer have been reviewed as have their folding pathways. AQPs may act as transmembrane ...
Randy Wayne (biologist)
Am J Bot 84:1522-1529 Christophe Maurel (June 1997). "AQUAPORINS AND WATER PERMEABILITY OF PLANT MEMBRANES". Annual Review of ... Wayne's work preceded the molecular identification of aquaporins in plant cells. It is generally believed that the ... Kaldenhoff, R., Bertl, A., Otto, B., Moshelion, M. and Uehlein, N. (2007). "Characterization of Plant Aquaporins". Osmosensing ... S2CID 15863712.CS1 maint: multiple names: authors list (link) Maurel, Christophe (1997). "Aquaporins and Water Permeability of ...
Tachyon (software)
"Water Permeation Through Aquaporins". Theoretical and Computational Biophysics Group, University of Illinois at Urbana- ...
Ruth Lyttle Satter
https://doi.org/10.1016/j.febslet.2007.04.002 Uehlein, N., & Kaldenhoff, R. (2007). Aquaporins and Plant Leaf Movements. Annals ...
Hydrotropism
Bellati, J; Champeyroux, C; Hem, S; Rofidal, V; Krouk, G; Maurel, C; Santoni (2016). "Novel aquaporin regulatory mechanisms ... Li, G; Santoni, V; Maurel, C (2014). "Plant aquaporins: roles in plant physiology". Biochimica et Biophysica Acta (BBA) - ... of their apt location in the cell membranes of root caps as well as their interactions and effect on a type of aquaporin water ...
Syndrome of inappropriate antidiuretic hormone secretion
... via activation of aquaporins, the site of the ADH receptors - back into the circulation. This has two consequences. First, in ... aquaporin 2), and their insertion into the cells' luminal membranes. Excessive ADH causes an inappropriate increase in the ... "Physiology and pathophysiology of renal aquaporins". Seminars in Nephrology. 21 (3): 231-8. doi:10.1053/snep.2001.21647. PMID ... where vasopressin release and response are normal but where abnormal renal expression and translocation of aquaporin 2, or both ...
Transmembrane channels
Aquaporins are dedicated channels for the movement of water across the hydrophobic interior of the cell membrane. Ion channels ... Verkman, A. (2011) Aquaporins at a Glance. Journal of Cell Science 24, 2107 - 2112. Roux, B., and Schulten, K. (2004). ...
Primary effusion lymphoma
Marlar S, Jensen HH, Login FH, Nejsum LN (October 2017). "Aquaporin-3 in Cancer". International Journal of Molecular Sciences. ... aquaporin 3, is a water channel that when overexpressed is thought to promote the progression and spread of various types of ...
Cation-chloride cotransporter
... aquaporins versus cotransporters". Biophysical Journal. 99 (11): 3647-3656. Bibcode:2010BpJ....99.3647M. doi:10.1016/j.bpj. ...
Blastulation
This movement of water is facilitated by aquaporins. A seal is created by tight junctions of the epithelial cells that line the ...
Peter Agre
Agre was recognized for his discovery of aquaporin water channels. Aquaporins are water-channel proteins that move water ... Aquaporins are "the plumbing system for cells," said Agre. Every cell is primarily water. "But the water doesn't just sit in ... Aquaporin Roderick MacKinnon Gheorghe Benga "The Nobel Prize in Chemistry 2003". www.nobelprize.org. Retrieved March 21, 2018. ... The 28 kDa protein is now known as aquaporin-1 (abbreviated AQP1), the archetypal member of a large family of water channel ...
Glymphatic system
Two types of aquaporins are expressed in the CNS: aquaporin-1, which is expressed by specialized epithelial cells of the ... Aquaporins are membrane-bound channels that play critical roles in regulating the flux of water into and out of cells. Relative ... Aquaporin-4 expression in astrocytes is highly polarized to the endfoot processes ensheathing the cerebral vasculature. Up to ... Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC (August 2006). "Three distinct roles of aquaporin-4 in brain ...
AQP5
Aquaporin-5 is a protein that in humans is encoded by the AQP5 gene. Aquaporin 5 (AQP5) is a water channel protein. Aquaporins ... "Entrez Gene: AQP5 aquaporin 5". Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): ... 2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008- ... 2007). "Stimulation of aquaporin-5 and transepithelial water permeability in human airway epithelium by hyperosmotic stress". ...
AQP9
Aquaporin-9 is a protein that in humans is encoded by the AQP9 gene. The aquaporins/major intrinsic protein are a family of ... Aquaporin 9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin 9 allows passage of a ... "Entrez Gene: AQP9 aquaporin 9". Ishibashi K, Kuwahara M, Gu Y, et al. (1998). "Cloning and functional expression of a new ... 2003). "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine". FEBS Lett. 540 (1-3): 157-62 ...
Neuromyelitis optica spectrum disorder
In 2005 they identified the aquaporin 4 protein as the target of the disease, and developed first in-house test to aid in the ... In more than 80% of cases, IgG autoantibodies against aquaporin-4 (anti-AQP4+) are the cause, and in 10-40% of the remaining ... In more than 80% of cases, NMO is caused by immunoglobulin G autoantibodies to aquaporin 4 (anti-AQP4), the most abundant water ... Some authors propose to use the name "autoimmune aquaporin-4 channelopathy" for these diseases, while others prefer a more ...
AQP7
Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin ... Aquaporin-7 is a protein that in humans is encoded by the AQP7 gene. Aquaporins/major intrinsic protein (MIP) are a family of ... "Entrez Gene: AQP7 aquaporin 7". Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated ... Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. ...
AQP8
Aquaporin-8 is a protein that in humans is encoded by the AQP8 gene. Aquaporin 8 (AQP8) is a water channel protein. Aquaporins ... "Entrez Gene: AQP8 aquaporin 8". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of ... 2007). "Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis". World J. ... Wang S, Chen J, Au KT, Ross MG (2003). "Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in ...
Semipermeable membrane
Aquaporins are protein channel pores permeable to H2O water. The diffusion of water through a selectively permeable membrane is ...
AQP6
The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family ... "Entrez Gene: Aquaporin 6, kidney specific". Retrieved 2012-04-10. Human AQP6 genome location and AQP6 gene details page in the ... Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M (Oct 2002). "Characterization of aquaporin-6 as a nitrate channel in ... Wang W, Hart PS, Piesco NP, Lu X, Gorry MC, Hart TC (Mar 2003). "Aquaporin expression in developing human teeth and selected ...
Balo concentric sclerosis
Balo-like lesions have been reported in aquaporin-4 seropositive and seronegative NMOSD, and also in children, as part of an ... Nov 2010). "Aquaporin-4 astrocytopathy in Baló's disease". Acta Neuropathologica. 120 (5): 651-660. doi:10.1007/S00401-010-0733 ... similar to the one found in aquaporin-seropositive neuromyelitis optica. Though no anti-NMO antibodies have been found, the ...
Blood-Spinal Cord Barrier
Nicaise C, Soyfoo MS, Authelet M, De Decker R, Bataveljic D, Delporte C, Pochet R (December 2008). "Aquaporinā4 Overexpression ... They release secretory compounds that influence the phenotype of endothelial cells and express aquaporin and potassium channels ...
Arabidopsis thaliana responses to salinity
Molecular and Cellular Features of Aquaporin Expression". Plant Physiology. 139 (2): 790-805. doi:10.1104/pp.105.065029. PMC ...
Vasopressin
Aquaporins allow water to move down their osmotic gradient and out of the nephron, increasing the amount of water re-absorbed ... Vasopressin, acting through cAMP, also increases transcription of the aquaporin-2 gene, thus increasing the total number of ... This occurs through increased transcription and insertion of water channels (Aquaporin-2) into the apical membrane of ... Wilson JL, Miranda CA, Knepper MA (2013). "Vasopressin and the Regulation of Aquaporin-2". Clinical and Experimental Nephrology ...
Tetrameric protein
... some aquaporins, some AMPA receptors, as well as some enzymes. Ion-exchange chromatography is useful for isolating specific ... "Heterotetrameric Composition of Aquaporin-4 Water Channels". Biochemistry. 38 (34): 11156-63. doi:10.1021/bi990941s. PMID ...
Hyponatremia
... occurs in one of two ways: either the osmoreceptor-aquaporin feedback loop is overwhelmed, or it is interrupted. ... "Physiology and pathophysiology of renal aquaporins". Seminars in nephrology. 21 (3): 231-8. doi:10.1053/snep.2001.21647. PMID ...
Ralf Kaldenhoff
Aquaporin tetramer composition modifies the function of tobacco aquaporins. Journal of Biological Chemistry, 2010. 285(41): p. ... He is known for his work on the aquaporin protein class, where he detected facilitated diffusion of CO2 in plant tissue and ... Kaldenhoff was one of the first scientists to describe plant aquaporins. He initially accomplished to analyse the function and ... For the first time, Kaldenhoff could provide evidence that an aquaporin molecule could conduct COā. Kaldenhoff also worked on ...
Abiotic stress
Another extremely important factor in dealing with drought stress and regulating the uptake and export of water is aquaporins ( ... "Aquaporins as potential drought tolerance inducing proteins: Towards instigating stress tolerance". Journal of Proteomics. 169 ...
Protein crystallization
Some proteins naturally form crystalline arrays, like aquaporin in the lens of the eye. In the process of protein ... "Aquaporins in the eye: Expression, function, and roles in ocular disease". Biochimica et Biophysica Acta (BBA) - General ...
Aphid
"A water-specific aquaporin involved in aphid osmoregulation". Insect Biochemistry and Molecular Biology. 39 (1): 1-10. doi: ...
Category:Aquaporins - Wikimedia Commons
Aquaporin transporter, Aquaporin_transptr, IPR034294 (en); Acquaporina (it); Aquaporin, ę°“åčē½, ę°“éé (zh); Canals daigua en la ... aquaporin (en); ę°“ééčē½ (zh); Aquaporin (da); Akvaporin (hu); ć¢ćÆć¢ććŖć³ (ja); Acquaporine (it); ΄ΓαĻĪæĻĪæĻĪÆĪ½ĪµĻ (el); akuaporin (id); ... Media in category "Aquaporins". The following 20 files are in this category, out of 20 total. ... Fluxes-of-Water-through-Aquaporin-9-Weaken-Membrane-Cytoskeleton-Anchorage-and-Promote-Formation-of-pone.0059901.s002.ogv 7.0 s ...
Involvement of aquaporins in colorectal carcinogenesis | Oncogene
Aquaporins (AQPs) are important in controlling water permeability. As AQP1 is known as a serum-responsive gene, we hypothesized ... Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets *Mahdieh-Sadat ... Moon, C., Soria, JC., Jang, S. et al. Involvement of aquaporins in colorectal carcinogenesis. Oncogene 22, 6699-6703 (2003). ... Aquaporins (AQPs) are important in controlling water permeability. As AQP1 is known as a serum-responsive gene, we hypothesized ...
Aquaporins in Melanocytic and Nonmelanocytic Skin Tumors
This study investigated the role of aquaporin 1 and aquaporin 3 in the pathobiology of skin cancers. Might they have potential ... Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors ... Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors. ...
Targeting Aquaporins for Conferring Salinity Tolerance in Crops | SpringerLink
Afzal Z, Howton TC, Sun Y, Mukhtar MS (2016) The roles of aquaporins in plant stress responses. J Dev Biol 4(1):9PubMedCentral ... Xu Y, Hu W, Liu J, Zhang J, Jia C, Miao H, Xu B, Jin Z (2014) A banana aquaporin gene, MaPIP1;1, is involved in tolerance to ... Maurel C, Boursiac Y, Luu DT, Santoni V, Shahzad Z, Verdoucq L (2015) Aquaporins in plants. Physiol Rev 95(4):1321-1358PubMed ... Pang Y, Li L, Ren F, Lu P, Wei P, Cai J, Xin L, Zhang J, Chen J, Wang X (2010) Overexpression of the tonoplast aquaporin AtTIP5 ...
Aquaporins in brain: distribution, physiology, and pathophysiology. - PubMed - NCBI
In rodent brain, several recent studies have demonstrated the presence of different types of aquaporins. Aquaporin 1 (AQP1) was ... Aquaporins in brain: distribution, physiology, and pathophysiology.. Badaut J1, Lasbennes F, Magistretti PJ, Regli L. ... Aquaporin 4 may also play a role in pathophysiologic conditions, as shown by the reduced edema formation observed after water ... A water channel family, the aquaporins, facilitates water flux through the plasma membrane of many cell types. ...
Aquaporin - Wikipedia
This results in aquaporin-2 containing vesicles to increase water uptake and return to circulation. Mutation of the aquaporin 2 ... The gating of an aquaporin is carried out by an interaction between a gating mechanism and the aquaporin, which causes a 3D ... It was not until 1992 that the first aquaporin, aquaporin-1 (originally known as CHIP 28), was reported by Peter Agre, of ... There have been two clear examples of diseases identified as resulting from mutations in aquaporins: Mutations in the aquaporin ...
Aquaporin 11/12 (IPR016697) | InterPro | EMBL-EBI
Aquaporin 11/12 (IPR016697). Short name: Aquaporin_11/12 Family relationships *Major intrinsic protein (IPR000425) *Aquaporin ... The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which ... AQP11 is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily [ ... Aquaporins 11 and 12 are classified as members of a new AQP subfamily: the subcellular AQPs [PMID: 17178102]. AQP 11 and 12 ...
Aquaporin 3 - Wikipedia
Aquaporin 3 is expressed more in atopic eczema. Recent studies indicate that aquaporin 3 is overexpressed in many types of ... Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family ... Aquaporin 3 is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal collecting ... 2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line". J. Membr. Biol. ...
The Role of Tight Junctions and Aquaporins in Skin Dryness | SpringerLink
Byakkokaninjinto prevents body water loss by increasing the expression of kidney aquaporin-2 and skin aquaporin-3 in KKAy mice ... Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? Biochim Biophys Acta 1758:1034 ... Verkman AS (2009) Aquaporins: translating bench research to human disease. J Exp Biol 212:1707-1715PubMedGoogle Scholar ... Cao C, Sun Y, Healey S, Bi Z, Hu G, Wan S, Kouttab N, Chu W, Wan Y (2006) EGFR-mediated expression of aquaporin-3 is involved ...
Cells | Free Full-Text | Insight into Salivary Gland Aquaporins
... in which aquaporins (AQPs) play a key role by ensuring water flow. The AQPs are transmembrane channel proteins permeable to ... Keywords: aquaporin; salivary gland; physiology; pathophysiology; regenerative medicine; xerostomia aquaporin; salivary gland; ... The main role of salivary glands (SG) is the production and secretion of saliva, in which aquaporins (AQPs) play a key role by ... The Aquaporin 3 Promoter Polymorphism ā1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in ...
Aquaporin A/S Profile
Aquaporin is dedicated to revolutionizing water purification through the use of industrial biotechn ... Aquaporin A/S is a global cleantech company located in Kongens Lyngby, Denmark. ... An essential building block in the water membrane technology of Aquaporin A/S is the aquaporin molecule. The aquaporin molecule ... The understanding of aquaporins and their role in life has opened the possibility of using aquaporins in an industrial context ...
Recent Articles | Aquaporins And Immunology | The Scientist MagazineĀ®
RS RS22555 aquaporin family protein [Ralstonia solanacearum GMI1000] - Gene - NCBI
WP_043876861.1 aquaporin family protein [Ralstonia solanacearum]. Conserved Domains (1) summary. COG0580. Location:1 ā 212. ... aquaporin family protein. Locus tag. RS_RS22555. Gene type. protein coding. Organism. Ralstonia solanacearum GMI1000 (strain: ... RS_RS22555 aquaporin family protein [ Ralstonia solanacearum GMI1000 ] Gene ID: 1223439, updated on 31-May-2017 ... GlpF; Glycerol uptake facilitator and related aquaporins (Major Intrinsic Protein Family) [Carbohydrate transport and ...
Immunohistochemical localization of aquaporins in the human inner ear
We report the immunolocalization of aquaporins (AQPs) 1, 4, and 6 in the human auditory and vestibular endorgans. A rapid ... Immunohistochemical localization of aquaporins in the human inner ear Cell Tissue Res. 2007 Jun;328(3):453-60. doi: 10.1007/ ... We report the immunolocalization of aquaporins (AQPs) 1, 4, and 6 in the human auditory and vestibular endorgans. A rapid ...
aquaporin - junctional and nonjunctional
Aquaporins | BPMP
Aquaporin, Hydraulics, Phosphorylation, Roots, Water stress, Water transport. Presentation. The Aquaporin team studies the ... Maurel Cā, Boursiac Y, Luu D-T, Santoni V, Shahzad Z, Verdoucq L (2015) Aquaporins in plants. Physiol. Rev., 95(4):1321-1358 ... Aquaporins. Group leader : Christophe Maurel. CNRS Research Director. TĆ©l : 04 99 61 20 11. Mail : [email protected] ... Bellati J, Champeyroux C, Hem S, Rofidal V, Krouk G, Maurel C, Santoni Vā (2016) Novel aquaporin regulatory mechanisms revealed ...
Urinary Excretion of Kidney Aquaporins as Possible Diagnostic Biomarker of Diabetic Nephropathy
Recent Articles | Aquaporins And Culture | The Scientist MagazineĀ®| Page 5
Frontiers | Mutual Interactions between Aquaporins and Membrane Components | Plant Science
Specific sites of protein-aquaporin interaction have been evaluated and new regulations of aquaporins described based on these ... Aquaporin isoforms heterotetramerizations are considered as novel regulatory mechanisms for plasma membrane (PIPs) and ... Aquaporin isoforms heterotetramerizations are considered as novel regulatory mechanisms for plasma membrane (PIPs) and ... The chemical composition or physical characteristics of the lipid bilayer also influences many aspects of membrane aquaporins, ...
Aquaporin 9 peptide (ab56306) | Abcam
TNF- Regulates Natriuretic Peptides and Aquaporins in Human Bronchial Epithelial Cells BEAS-2B
J. E. Towne, C. M. Krane, C. J. Bachurski, and A. G. Menon, "Tumor necrosis factor-α inhibits aquaporin 5 expression in mouse ... J. M. Carbrey and P. Agre, "Discovery of the aquaporins and development of the field," Handbook of Experimental Pharmacology, ... O. Bloch and G. T. Manley, "The role of aquaporin-4 in cerebral water transport and edema," Neurosurgical Focus, vol. 22, no. 5 ... J. E. Towne, K. S. Harrod, C. M. Krane, and A. G. Menon, "Decreased expression of aquaporin (AQP)1 and AQP5 in mouse lung after ...
IJMS | Free Full-Text | Fragment Screening of Human Aquaporin 1
... to identify effective and specific inhibitors of aquaporins. In this paper, we have screened a library of 1500 ... Aquaporins (AQPs) are membrane proteins that enable water transport across cellular plasma membranes in response to osmotic ... This article belongs to the Special Issue Aquaporin) View Full-Text , Download PDF [9881 KB, uploaded 25 March 2016] , Browse ... Aquaporins (AQPs) are membrane proteins that enable water transport across cellular plasma membranes in response to osmotic ...
Structure of a Nobel-prize winning molecule: Aquaporin
The architecture of aquaporin Z is typical of aquaporins, with a spiral of eight oxygens providing water-binding sites inside ... Aquaporins form a large, diverse family of proteins and have been found in bacteria, plants, and animals. Less than a decade ... The aquaporin Z channel protein in E. coli can accommodate a flow of water at rates six times higher than GlpF ( ... And because the two main classes of aquaporins occur in E. coli--which means theyre exposed to the same cellular environment-- ...
Novel Regulation of Aquaporins during Osmotic Stress | Plant Physiology
Novel Regulation of Aquaporins during Osmotic Stress. Rosario Vera-Estrella, Bronwyn J. Barkla, Hans J. Bohnert, Omar Pantoja ... Quigley F, Rosenberg JM, Shachar-Hill Y, Bohnert HJ (2002) From genome to function: the Arabidopsis aquaporins. Genome Biol 3: ... Knepper MA, Inoue T (1997) Regulation of aquaporin-2 water channel trafficking by vasopressin. Curr Opin Cell Biol 9: 560-564. ... Uehlein N, Lovisolo C, Siefritz F, Kaldenhoff R (2003) The tobacco aquaporin NtAQP1 is a membrane CO2 pore with physiological ...
Anti-Aquaporin 3 antibody (ab15117) | Abcam
Rabbit polyclonal Aquaporin 3 antibody. Validated in WB, ELISA, IHC and tested in Rat. Cited in 1 publication(s). Independently ... Anti-Aquaporin 3 antibody (ab15117). Rabbit polyclonal Aquaporin 3 antibody. Validated in WB, ELISA, IHC and tested in Rat. ... Primary - Rabbit Anti-Aquaporin 3 antibody (ab15117) WB, ELISA, IHC-Fr Secondary - Goat Anti-Rabbit IgG H&L (HRP) (ab205718) ... Hi, I would like to know if antibody aquaporin 3 cat#ab15117 is an extracellular antibody and can it be used for FACS? Thanks ...
Estrogen Regulation of Aquaporins in the Mouse Uterus: Potential Roles in Uterine Water Movement1
Elizabeth M. Jablonski, Nisha A. McConnell, Francis M. Hughes, and Yvette M. Huet-Hudson "Estrogen Regulation of Aquaporins in ... Estrogen Regulation of Aquaporins in the Mouse Uterus: Potential Roles in Uterine Water Movement. ... Elizabeth M. Jablonski, Nisha A. McConnell, Francis M. Hughes, Yvette M. Huet-Hudson "Estrogen Regulation of Aquaporins in the ... we have explored the expression profile and functionality of water channels termed aquaporins (AQPs) in the ovariectomized ...
aqp9b - Aquaporin 9b - Danio rerio (Zebrafish) - aqp9b gene & protein
R-DRE-432030, Transport of glycerol from adipocytes to the liver by Aquaporins. R-DRE-432047, Passive transport by Aquaporins ... R-DRE-432030, Transport of glycerol from adipocytes to the liver by Aquaporins. R-DRE-432047, Passive transport by Aquaporins ... Aquaporin 9bImported. ,p>Information which has been imported from another database using automatic procedures.,/p> ,p>,a href ... Belongs to the MIP/aquaporin (TC 1.A.8) family. [View classification]UniRule annotation. Automatic assertion according to rules ...
Auxin regulates aquaporin function to facilitate lateral root emergence
In plants, aquaporins contribute to water relations. Here, we establish a new link between aquaporin-dependent tissue ... Aquaporins are membrane channels that facilitate water movement across cell membranes. ... In plants, aquaporins contribute to water relations. Here, we establish a new link between aquaporin-dependent tissue ... Auxin regulates aquaporin function to facilitate lateral root emergence Nat Cell Biol. 2012 Oct;14(10):991-8. doi: 10.1038/ ...
Quiz & Worksheet - Aquaporins | Study.com
One way is through the use of aquaporins. Use this assessment to assess how well you understand the functions of aquaporins. ... 2. Aquaporins are protein tunnels that allow which important molecule to travel across a cell membrane?. ... For an effective review, complete the related lesson Aquaporins: Definition & Functions. Use this review to prepare for ... Information recall - access the knowledge youve gained regarding the functions of aquaporins ...
PIP1 Plasma Membrane Aquaporins in Tobacco | Plant Cell
The molecular functions of several aquaporins are well characterized (e.g., by analysis of aquaporin-expressing Xenopus oocytes ... PIP1 Plasma Membrane Aquaporins in Tobacco. Franka Siefritz, Melvin T. Tyree, Claudio Lovisolo, Andrea Schubert, Ralf ... PIP1 Plasma Membrane Aquaporins in Tobacco. Franka Siefritz, Melvin T. Tyree, Claudio Lovisolo, Andrea Schubert, Ralf ... Many organisms lacking a specific aquaporin have an unobtrusive phenotype, which suggests that aquaporins are unimportant or ...
AQPsProteinsAQP1ProteinAnti-AquaporinAQP4PermeabilityMolecularAntibodyRole of aquaporinsMoleculeRegulationGeneExpression of aquaporinAQP2MembranesRegulatesDifferent aquaporinsIsoformsPhosphorylationGenesSelectivityPathophysiologyNeuromyelitis opticaPhysiologyAQP0Glycerol and ureaAsparagine-proline-alanineKnown as CHIP 28TumorAntibodiesArabidopsisSelectivelyHomeostasisFunctionalHumanKidneyUreaSuggests that aquaporinsCellsAQP5AQP9Roles of aquaporinsIntracellularMiceFacilitateAQP3IonsPeptideMammalian aquaporinsPoreOsmotic
AQPs23
- Aquaporins (AQPs) are important in controlling water permeability. (nature.com)
- The aquaporins (AQPs) are a family of integral membrane proteins composed of two subfamilies: the orthodox aquaporins, which transport only water, and the aquaglyceroporins, which transport glycerol, urea, or other small solutes [ PMID: 16650285 ]. (ebi.ac.uk)
- Aquaporins 11 and 12 are classified as members of a new AQP subfamily: the subcellular AQPs [ PMID: 17178102 ]. (ebi.ac.uk)
- The main role of salivary glands (SG) is the production and secretion of saliva, in which aquaporins (AQPs) play a key role by ensuring water flow. (mdpi.com)
- We report the immunolocalization of aquaporins (AQPs) 1, 4, and 6 in the human auditory and vestibular endorgans. (nih.gov)
- Plants aquaporins (AQPs) are molecular proteinaceous membrane channels that finely control the passage of water through membranes. (frontiersin.org)
- Aquaporins (AQPs) are membrane proteins that enable water transport across cellular plasma membranes in response to osmotic gradients. (mdpi.com)
- To gain insight into the mechanisms underlying this estrogen-stimulated water transport, we have explored the expression profile and functionality of water channels termed aquaporins (AQPs) in the ovariectomized mouse uterus treated with ovarian steroid hormones. (bioone.org)
- Aquaporins (AQPs) are integral membrane proteins that form pores in the membrane of biological cells. (cosmeticsandtoiletries.com)
- 3Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China Introduction: Aquaporins (AQPs), also called water channels, have been shown to have functions in the migration, invasion, and proliferation of human breast tumor cells. (doaj.org)
- Aquaporins (AQPs) are an ancient family of channel proteins that transport water and neutral solutes through a pore and are found in all eukaryotes and most prokaryotes. (plantphysiol.org)
- Aquaporins (AQPs) are an ancient family of channel proteins that transport water and certain neutral metabolites across biological membranes. (plantphysiol.org)
- Recently, fluxes of water through membrane-anchored water channels, aquaporins (AQPs), have been implicated in cell motility, while they appeared to localize to lamellipodia and facilitate cell locomotion. (diva-portal.org)
- The eye contains numerous water channel proteins and the roles of AQPs (aquaporins) in the retina are blurred, especially under disease conditions. (portlandpress.com)
- AQPs (aquaporins) are hydrophobic membrane proteins and the narrowest diameter of the pore of AQPs is 2.8 Ć (1 Ć =0.1 nm) [ 16 ]. (portlandpress.com)
- Aquaporins (AQPs) are tetrameric channel proteins regulating the transmembrane flux of small uncharged solutes and in particular water in living organisms. (frontiersin.org)
- Aquaporins (AQPs) are transmembrane channel proteins that control the facilitated diffusion of water and other uncharged solutes such as glycerol, hydrogen peroxide, ammonia, small organic acids, urea, and metalloids ( Chaumont and Tyerman, 2017 ). (frontiersin.org)
- Contents Aquaporins (AQPs) are essential membrane protein channels for the transport of water across membranes. (ovid.com)
- The aquaporins (AQPs) are small integral membrane proteins that transport water and in some cases small solutes such as glycerol. (springer.com)
- Water movement within the follicular wall is predominantly transcellular via membranous water channels named aquaporins (AQPs). (unboundmedicine.com)
- Aquaporins (AQPs) are membrane proteins that form water channels, allowing rapid movement of water across cell membranes. (biologists.org)
- Transmembrane fluxes of water via specialized water channels, called aquaporins (AQPs), facilitate the changes of volume and shape, which additionally require a complex interplay between the plasma membrane and the cytoskeleton. (diva-portal.org)
- Aquaporins (AQPs) are members of major intrinsic proteins and form water conducting channels in the biological membranes. (tu-darmstadt.de)
Proteins32
- also called aquaporins) are membrane channel proteins initially discovered as water channels, but their roles in the transport of small neutral solutes, metal ions, and gasses are now well established. (springer.com)
- Aquaporins, also called water channels, are channel proteins from a larger family of major intrinsic proteins that form pores in the membrane of biological cells, mainly facilitating transport of water between cells. (wikipedia.org)
- Also known as water channels, aquaporins are integral membrane pore proteins. (wikipedia.org)
- AQP11 is functionally distinct from other proteins of the aquaporin superfamily and could represent a new aquaporin subfamily [ PMID: 16650285 ]. (ebi.ac.uk)
- Benga G (2009) Water channel proteins (later called aquaporins) and relatives: past, present, and future. (springer.com)
- The water-transporting task is accomplished by aquaporin water channel proteins (Preston et al. (environmental-expert.com)
- Aquaporins, channel proteins that facilitate the transfer of water across cell membranes, play a central role in maintaining the plant water status. (inra.fr)
- Heterotetramerizations of aquaporin isoforms are considered as novel regulatory mechanisms for plasma membrane (PIPs) and tonoplast (TIPs) proteins, influencing their intrinsic permeability and trafficking dynamics in the adaptive response to changing environmental conditions. (frontiersin.org)
- Aquaporins form a large, diverse family of proteins and have been found in bacteria, plants, and animals. (innovations-report.com)
- Many organisms lacking a specific aquaporin have an unobtrusive phenotype, which suggests that aquaporins are unimportant or can be substituted by homolog proteins or compensatory mechanisms. (plantcell.org)
- Water is 'turned on' and 'turned off' by membrane proteins that function as water conduits and are called aquaporins. (innovations-report.com)
- Aquaporins are channel producing proteins which regulate the flow of water across the cell membrane. (proteopedia.org)
- Aquaporins are proteins that facilitate transport of water across biological membranes. (sciencemag.org)
- [1] AQP4 belongs to the aquaporin family of integral membrane proteins that conduct water through the cell membrane . (wikidoc.org)
- Aquaporins are a class of proteins that form membrane channels in cell walls and allow for water movement between a cell and its surroundings. (phys.org)
- Aquaporins are integral membrane proteins that specialize in the regulation of cellular water flow across the cell membrane. (proteopedia.org)
- Because there are many other variants of aquaporins throughout the body, Lennon suggests that these proteins might play a role in poorly understood autoimmune disorders in other organ systems. (rxpgnews.com)
- Previously unidentified phosphorylation sites were found for membrane proteins essential to collecting duct physiology, including eight sites among aquaporin-2 (AQP2), aquaporin-4, and urea transporter isoforms A1 and A3. (pnas.org)
- Aquaporins form a family of water and solute channel proteins and are present in most living organisms. (mcponline.org)
- Aquaporins form a family of channel proteins that mediate the transport across membranes of water, small neutral solutes, and occasionally ions ( 1 - 3 ). (mcponline.org)
- Aquaporins are 25-35-kDa proteins that share a typical organization with six transmembrane α-helices interrupted by five connecting loops (loops A-E ) ( 7 , 8 ). (mcponline.org)
- Background: Aquaporins are a large family of transmembrane channel proteins that are present throughout all domains of life and are implicated in human disorders. (ebscohost.com)
- Additionally we are shipping Aquaporin 5 Kits (45) and Aquaporin 5 Proteins (4) and many more products for this protein. (antibodies-online.com)
- This family of integral membrane proteins includes both water selective pores (aquaporins) and transport facilitators of other small molecules such as glycerol and urea (aquaglyceroporins). (lu.se)
- Aquaporins are membrane proteins that form channels (centre) that help water molecules (red and white spheres) pass in and out of cells. (sciencephoto.com)
- The plant aquaporin family of the Nodulin26-like intrinsic proteins was named because of the high structural and functional similarity to soybean Nodulin 26. (tu-darmstadt.de)
- Water channel proteins, known as aquaporins, are transmembrane proteins that mediate osmotic water permeability. (acris-antibodies.com)
- Aquaporins are integral membrane proteins , which function as specialized water channels to facilitate the passage of water through the cell membrane . (ndif.org)
- What follows in this process is not entirely clear, but it leads to water-transporting proteins called aquaporin-2 ( AQP2 proteins ) traveling from their holding place inside the CD cell to the apical membrane of the cell . (ndif.org)
- Aquaporins are an ancient family of proteins that provide a route for water to rapidly move in and out of cells in response to the changing needs of the body. (findaphd.com)
- Aquaporins are a family of water channel proteins that facilitates water transport across the plasma membrane. (arvojournals.org)
- We propose a model of hagfish slime mucin vesicle rupture that involves Ca 2+ -activated transporters and aquaporins, and suggest that the presence of these proteins is an adaptation for increasing the speed of vesicle rupture and, consequently, the speed of the sliming response of hagfishes. (biologists.org)
AQP18
- Aquaporin 1 (AQP1) was detected on epithelial cells in the choroid plexus whereas AQP4, AQP5 and AQP9 were localized on astrocytes and ependymal cells. (nih.gov)
- In kidneys, this is made possible mainly by two aquaporins denoted AQP1 and AQP2 (11 different aquaporins are known in humans). (environmental-expert.com)
- A limited number of aquaporins are found within the central nervous system (CNS): AQP1, 3, 4, 5, 8, 9, and 11, but more exclusive representation of AQP1, 4, and 9 are found in the brain and spinal cord. (wikidoc.org)
- Aquaporin-1 (AQP1) was first discovered in human red blood cell membranes by Gheorghe Benga's research group in 1986. (proteopedia.org)
- Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. (shapeways.com)
- The Aqp1b belongs to a teleost-specific subfamily of water-selective aquaporins, similar to mammalian aquaporin-1 (AQP1) that has possibly evolved by duplication of a common ancestor and further neofunctionalization in oocytes of marine teleosts for water uptake. (csic.es)
- Mice that lack the aquaporin-1 gene ( AQP1 ) lack a functional countercurrent multiplier mechanism , fail to concentrate the inner medullary (IM) interstitium and present with a urinary concentrating defect . (ndif.org)
- Mice that do not have the aquaporin-1 ( AQP1 ) gene are unable to concentrate urine . (ndif.org)
Protein27
- Aquaporin-11: a channel protein lacking apparent transport function expressed in brain. (ebi.ac.uk)
- Aquaporin 3 is the protein product of the human AQP3 gene. (wikipedia.org)
- Specific sites of protein-aquaporin interaction have been evaluated and new forms of regulation of aquaporins described, based on these associations. (frontiersin.org)
- The aquaporin Z channel protein in E. coli can accommodate a flow of water at rates six times higher than GlpF (aquaglyceroporin glycerol facilitator, a channel protein that transports both glycerol and water in E. coli) making it the prime subject for studying the selectivity of a high-conducting water channel. (innovations-report.com)
- Aquaporin protein regulation and redistribution in response to osmotic stress was investigated. (plantphysiol.org)
- Mannitol-induced water imbalance resulted in increased protein amounts in tonoplast fractions and a shift in protein distribution to other membrane fractions, suggesting aquaporin relocalization. (plantphysiol.org)
- 2. Aquaporins are protein tunnels that allow which important molecule to travel across a cell membrane? (study.com)
- Aquaporin-4, also known as AQP4, is a water channel protein encoded by the AQP4 gene in humans. (wikidoc.org)
- Neuromyelitis optica (NMO) is an inflammatory disease affecting the optic nerve and spinal cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably play a pathogenic role. (pnas.org)
- Aquaporin-1 is an integral membrane protein that is considered to have an "open" structure. (proteopedia.org)
- Protein Kinase C (PKC) has been documented as a common signal transducer among the aquaporins. (proteopedia.org)
- Benga G. The first discovered water channel protein, later called aquaporin 1: molecular characteristics, functions and medical implications. (proteopedia.org)
- Aquaporin-0 (AQP0), a water transport channel protein, is the major intrinsic protein (MIP) of lens fiber cell plasma membranes. (uniprot.org)
- The protein, called aquaporin-4, is a channel protein that allows water to move in and out of cells. (rxpgnews.com)
- In this work, we investigated the role of phosphorylation of plasma membrane intrinsic protein (PIP) aquaporins in the Arabidopsis thaliana root by a combination of quantitative mass spectrometry and cellular biology approaches. (mcponline.org)
- To investigate a putative role of Ser 280 and Ser 283 phosphorylation in aquaporin subcellular trafficking, At PIP2;1 forms mutated at either one of the two sites were fused to the green fluorescent protein and expressed in transgenic plants. (mcponline.org)
- A synthetic peptide from the n-terminal region of human Aquaporin 7 (AQP7) conjugated to an immunogenic carrier protein was used as the immunogen. (novusbio.com)
- Aquaporins/major intrinsic protein (MIP) are a family of water-selective membrane channels. (novusbio.com)
- Aquaporin 5 (AQP5) is a water channel protein. (antibodies-online.com)
- In this study, we determined the pseudoatomic structure of full-length mammalian aquaporin-0 (AQP0, Bos taurus) in complex with CaM, using EM to elucidate how this signaling protein modulates water-channel function. (rcsb.org)
- Artwork of the plasma membrane (purple) of a cell showing an aquaporin (AQP, blue), an embedded protein that regulates the flow of water molecules into and out of the cell. (sciencephoto.com)
- Computer illustration showing the structure of a molecule of the human aquaporin 1 protein (blue, and white ribbon). (sciencephoto.com)
- Anti-Aquaporin 5, rabbit polyclonal, recognizes the ~28 kDa AQP 5 protein in epithelial tissue extracts. (emdmillipore.com)
- Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. (rupress.org)
- In Arabidopsis thaliana , mRNA levels of one of the aquaporin genes, TIP2;2 , increase during dark adaptation and decrease under far-red light illumination, but the effects of light at the protein level and on the mechanism of light regulation remain unknown. (mdpi.com)
- AQP6 is located on human 12q13 chromosome and exhibit significant homology with other aquaporin protein. (acris-antibodies.com)
- This aquaporin gene encoded a functional water-channel protein, as demonstrated by heterologous expression assays in Saccharomyces cerevisiae . (apsnet.org)
Anti-Aquaporin5
- It is now known that serum anti-aquaporin 4 (AQP4) autoantibodies can be used as a disease marker of NMO ( 1 , 2 ). (pnas.org)
- Anti-Aquaporin 11 (extracellular) antibody , (1:1000). (acris-antibodies.com)
- Anti-Aquaporin 11 (extracellular) antibody, preincubated with the control peptide antigen. (acris-antibodies.com)
- Anti-Aquaporin 6 antibody , (1:200). (acris-antibodies.com)
- AbstractPurposeAlthough many assays have been developed to detect anti-aquaporin-4 (AQP4) antibodies, most of these assays require sophisticated techniques and are thus only available at specialized laboratories. (medworm.com)
AQP412
- Aquaporin 4 may also play a role in pathophysiologic conditions, as shown by the reduced edema formation observed after water intoxication and focal cerebral ischemia in AQP4-knockout mice. (nih.gov)
- [2] In the CNS, AQP4 is the most prevalent aquaporin channel, specifically located at the perimicrovessel astrocyte foot processes, glia limitans, and ependyma. (wikidoc.org)
- [5] Similar to other aquaporin channels, the monomers of AQP4 assemble into tetramers . (wikidoc.org)
- [11] Aquaporin-4 is the predominant autoimmune target in neuromyelitis optica, or NMO, since a specific AQP4 IgG autoantibody, or NMO-IgG, binds to the extracellular surface of AQP4. (wikidoc.org)
- Neuromyelitis optica (NMO) is an autoimmune CNS disorder mediated by pathogenic aquaporin-4 (AQP4) water channel autoantibodies (AQP4-IgG). (jci.org)
- Osmotic water permeabilities of aquaporins AQP4 (show AQP4 Antibodies ), AQP5 , and GlpF from near-equilibrium simulations have been presented. (antibodies-online.com)
- In this report we show that NMO-IgG binds to the aquaporin-4 (AQP4) water channel. (rupress.org)
- Aquaporin-4 (AQP4), the main water channel of the brain, is highly expressed in animal glioma and human glioblastoma in situ. (biomedsearch.com)
- Influx of cerebrospinal fluid (CSF) depends upon the expression and perivascular localization of the astroglial water channel aquaporin-4 (AQP4). (lu.se)
- Aquaporin-4 (AQP4) is implicated in a number of physiopathological processes, particularly in the development of brain edema, and other functions such as the regulation of extracellular space volume, potassium buffering, waste clearance, and calcium signaling. (bioportfolio.com)
- Aquaporin-4 (AQP4) is the major water channel expressed at fluid-tissue barriers throughout the brain and plays a crucial role in cerebral water balance. (pubmedcentralcanada.ca)
- Aquaporin-4 (AQP4) is the major membrane water channel in the central nervous system. (pubmedcentralcanada.ca)
Permeability6
- Aquaporin-3 function is to promote glycerol permeability across cell membrane. (proteopedia.org)
- Results show that changes in the amino acid composition of the aromatic/arginine region affect the size and polarity of the selectivity filter (SF) and could help explain the difference in water permeability between aquaporins. (ebscohost.com)
- The researchers hypothesize that, as with water permeability, aquaporins may be physiologically relevant to gas exchange when cells have dense, rigid lipid bilayers or when aquaporins occupy a major fraction of the membrane. (biomedicalcomputationreview.org)
- Chou CL, Ma T, Yang B, Knepper MA, Verkman AS (1998) Fourfold reduction of water permeability in inner medullary collecting duct of aquaporin-4 knockout mice. (springer.com)
- Chou CL, Knepper MA, Hoek AN, Brown D, Yang B, Ma T, Verkman AS (1999) Reduced water permeability and altered ultrastructure in thin descending limb of Henle in aquaporin-1 null mice. (springer.com)
- In vivo analysis of aquaporin 0 function in zebrafish: permeability regulation is required for lens transparency. (semanticscholar.org)
Molecular17
- The molecular and cellular bases of this process are addressed by studying the multiple facets of aquaporin regulation. (inra.fr)
- The team combines molecular, physiological and genetic approaches and characterizes water transport at the level of cloned aquaporins, purified membranes, living cells or organs like excised roots or rosettes. (inra.fr)
- The molecular driving forces stabilizing the positions of the lipids around aquaporins could define their activity, thereby altering the conformational properties. (frontiersin.org)
- And because the two main classes of aquaporins occur in E. coli--which means they're exposed to the same cellular environment--the opportunities for comparative structural and functional analyses, combined with site-directed mutagenesis, promise to provide valuable insights into the molecular underpinnings of the selectivity of functionally different aquaporins. (innovations-report.com)
- With two structural models of aquaporins down to the atomic level in the same species, scientists can now begin to investigate the molecular mechanisms that facilitate their selectivity. (innovations-report.com)
- The molecular functions of several aquaporins are well characterized (e.g., by analysis of aquaporin-expressing Xenopus oocytes). (plantcell.org)
- This gave us an opportunity to compare open and closed aquaporins and to understand how this opening and closing works at the molecular level. (innovations-report.com)
- Agre P, Kozono D. Aquaporin water channels: molecular mechanisms for human diseases. (proteopedia.org)
- Taking advantage of the known crystal structure of aquaporin-1 and the power of molecular dynamics simulations, the researchers explored the central pore as a candidate pathway for conducting ions. (phys.org)
- Whereas the long term effect of this NaCl stress can be accounted for by an overall transcriptional down-regulation of aquaporins, the molecular mechanisms involved in the early inhibition of L p r by NaCl are not fully understood yet. (mcponline.org)
- Recent work, however, has uncovered the role of a novel molecular water channel (aquaporin), designated aquaporin-1b (Aqp1b), which facilitates water permeation and resultant swelling of the oocyte. (csic.es)
- Now molecular dynamics simulations of aquaporins have weighed in on the question. (biomedicalcomputationreview.org)
- Soveral, G, Nielsen, S & Casini, A (red) 2016, Aquaporins in health and disease: new molecular targets for drug discovery . (aau.dk)
- 3. How are aquaporins regulated in the cell and by what molecular partners? (findaphd.com)
- Molecular evolution of mammalian aquaporin-2. (uva.nl)
- Molecular evidence of two aquaporin homologues expressed in the slime glands further supports this idea. (biologists.org)
- Investigations on mercury sensitivity and molecular determinants of selectivity in two plant aquaporins. (tu-darmstadt.de)
Antibody5
- Rabbit polyclonal Aquaporin 3 antibody. (abcam.com)
- Aquaporin-7 Polyclonal antibody specifically detects Antigen in Human samples. (fishersci.com)
- There are currently no images for Aquaporin-7 Antibody (NBP1-30862). (novusbio.com)
- We have used a peptide-derived, affinity-purified polyclonal antibody to aquaporin-3 (AQP-3) to investigate its localization and regulation in the kidney. (sigmaaldrich.com)
- The following antibody was used in this experiment: Aquaporin 2 Polyclonal Antibody from Thermo Fisher Scientific, catalog # PA5-78808, RRID AB_2745924. (thermofisher.com)
Role of aquaporins3
- Agren J, Zelenin S, Hakansson M, Eklof AC, Aperia A, Nejsum LN, Nielsen S, Sedin G (2003) Transepidermal water loss in developing rats: role of aquaporins in the immature skin. (springer.com)
- Hence, the discussion about the role of aquaporins in the majority of multicellular organisms remains open ( Chrispeels and Maurel, 1994 ). (plantcell.org)
- In particular, physiological and genetics studies have provided compelling evidence for a role of aquaporins in the regulation, in response to abiotic stresses, of root water transport, i.e . root hydraulic conductivity ( L p r ) ( 10 , 11 ). (mcponline.org)
Molecule7
- However, because water is a polar molecule this process of simple diffusion is relatively slow, and the majority of water passes through aquaporin. (wikipedia.org)
- An essential building block in the water membrane technology of Aquaporin A/S is the aquaporin molecule. (environmental-expert.com)
- The aquaporin molecule is described in the following. (environmental-expert.com)
- Aquaporins contain a conduit that is so tiny that only a single water molecule at a time can pass through it. (innovations-report.com)
- Aquaporin-4 is the first specific molecule to be defined as a target for the autoimmune response in any form of MS. It is also the first example of a water channel being the target of any autoimmune disorder. (rxpgnews.com)
- Aquaporin-4 is the first specific molecule to be defined as a target for the autoimmune response in any form of MS," said author Vanda A. Lennon, MD, PhD, of the Mayo Clinic in Rochester, Minnesota. (rxpgnews.com)
- Aquaporins occur in groups of four (tetramers), with four pores that conduct water (one through each aquaporin molecule) and one central pore where the molecules meet. (biomedicalcomputationreview.org)
Regulation7
- Alexandersson E, Fraysse L, Sjƶvall-Larsen S, Gustavsson S, Fellert M, Karlsson M et al (2005) Whole gene family expression and drought stress regulation of aquaporins. (springer.com)
- [8] Other performances that aquaporin-4 is involved in are synaptic plasticity, astrocyte migration, regulation of extracellular space volume, and the homeostasis of potassium. (wikidoc.org)
- Aquaporin channels may be subject to intense short term regulation via signal transduction. (proteopedia.org)
- In plants, aquaporins play an important role in the regulation of root water transport in response to abiotic stresses. (mcponline.org)
- Chilling is another stress that leads to inhibition of L p r , and a relationship between aquaporin regulation and reactive oxygen species was established in this context ( 13 ). (mcponline.org)
- Aquaporin-3 water channel localization and regulation in rat kidney. (sigmaaldrich.com)
- Numerous studies have described the light regulation of aquaporin genes, but none have identified the regulatory mechanisms behind this regulation via specific photoreceptor signaling. (mdpi.com)
Gene6
- Abdelkader AF, El-khawas S, El-Din El-Sherif NA, Hassanein RA, Emam MA, Hassan RE (2012) Expression of aquaporin gene (OsPIP1-3) in salt-stressed rice ( Oryza sativa L.) plants pre-treated with the neurotransmitter (dopamine). (springer.com)
- Less than a decade ago, scientists discovered the aquaporin Z gene (aqpZ) in E. coli, pointing to the protein's role in regulating water transport in this prokaryote. (innovations-report.com)
- Our research group has been developing an adeno-associated virus vector based on the hypothesis that this vector is capable of safely transferring the human aquaporin-1 (hAQP1) cDNA gene to parotid glands of adult patients with IR-induced salivary hypofunction, resulting in an elevated salivary output. (clinicaltrials.gov)
- AQP9 (aquaporin 9) was first discovered in adipose tissue, and the AQP9 gene was successfully cloned. (creative-biogene.com)
- Da T, Verkman AS (2004) Aquaporin-4 gene disruption in mice protects against impaired retinal function and cell death after ischemia. (springer.com)
- We have characterized cDNAs from T. claveryi and identified a sequence related to the aquaporin gene family. (apsnet.org)
Expression of aquaporin1
- Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes). (wikipedia.org)
AQP23
- This peptide is a fragment of the human aquaporin-2 (AQP2) phosphorylated at Ser261. (anaspec.com)
- Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. (thermofisher.com)
- BACKGROUND: Arginine-vasopressin (AVP) binding to vasopressin V2 receptors promotes redistribution of the water channel aquaporin-2 (AQP2) from intracellular vesicles into the plasma membrane of renal collecting duct principal cells. (mdc-berlin.de)
Membranes7
- The cell membranes of a variety of different bacteria, fungi, animal and plant cells contain aquaporins through which water can flow more rapidly into and out of the cell than by diffusing through the phospholipid bilayer. (wikipedia.org)
- Aquaporins are membrane channels that facilitate water movement across cell membranes. (nih.gov)
- Aquaporins are membrane channels that facilitate the flow of water across biological membranes. (sciencemag.org)
- Upon transfection of salivary glands, adenovirus encoding human aquaporin-1 (AdhAQP1) directs human aquaporin-1 (hAQP1) expression in the apical and basolateral plasma membranes of salivary secretory cells, which may result in increased saliva production. (cancer.gov)
- Extensive research on the function of aquaporins have been implemented into many separate types of cell membranes. (proteopedia.org)
- Aquaporin-4 is concentrated in membranes in the precise site where spinal cord inflammation is found in NMO patients," said Lennon. (rxpgnews.com)
- Aquaporin-mediated water transport across cellular membranes is an ancient, ubiquitous mechanism within cell biology. (lu.se)
Regulates2
- Aquaporin-4 regulates water balance in the central nervous system. (proteopedia.org)
- Light regulates the expression and function of aquaporins, which are involved in water and solute transport. (mdpi.com)
Different aquaporins3
- In mammals six different aquaporins have been identified up to now, four of which ( aquaporin-1 to aquaporin-4 ) are expressed in the kidney . (ndif.org)
- Humans have 13 different aquaporins that allow water to pass at different speeds and have different selectivity behaviour (e.g. for glycerol and urea). (findaphd.com)
- 1. How do the different aquaporins have different rates of water transport? (findaphd.com)
Isoforms2
- Since then, 12 other isoforms of aquaporin-1 have been discovered and each have been classified under the family known as Aquaporins. (proteopedia.org)
- Now there are at least 12 isoforms of Aquaporins are cloned. (acris-antibodies.com)
Phosphorylation1
- Thus, the present study documents stress-induced quantitative changes in aquaporin phosphorylation and establishes for the first time a link with plant aquaporin subcellular localization. (mcponline.org)
Genes2
- Genetic defects involving aquaporin genes have been associated with several human diseases including nephrogenic diabetes insipidus and neuromyelitis optica. (wikipedia.org)
- We report that most aquaporin genes are repressed during lateral root formation and by exogenous auxin treatment. (nih.gov)
Selectivity3
- Ampah-Korsah H, Sonntag Y, Engfors A, Kirscht A, Kjellbom P, Johanson U (2017) Single amino acid substitutions in the selectivity filter render NbXIP1;1α aquaporin water permeable. (springer.com)
- This structure demonstrates that aquaporin selectivity arises in part from erecting a physical barrier: small molecules, like water, can easily pass, but larger ones simply can't fit. (innovations-report.com)
- Two conserved regions are central for selective function: the dual asparagine-proline-alanine (NPA) aquaporin signature motif and the aromatic and arginine selectivity filter (SF). (sciencemag.org)
Pathophysiology1
- Aquaporins in brain: distribution, physiology, and pathophysiology. (nih.gov)
Neuromyelitis optica1
- Aquaporin-4 is the primary autoimmune target of neuromyelitis optica. (proteopedia.org)
Physiology2
- Therefore, an integrative approach to the relevance of the membrane-aquaporin interaction to different processes related to plant cell physiology is provided. (frontiersin.org)
- Tanshinone IIA ameliorates seawater exposure-induced lung injury by inhibiting aquaporins (AQP) 1 and AQP5 expression in lung," Respiratory Physiology and Neurobiology , vol. 176, no. 1-2, pp. 39-49, 2011. (hindawi.com)
AQP02
- AQP0 aquaporin pores are mainly lined with alpha helices, which can be seen clearly using the cartoon representation. (csbsju.edu)
- Aquaporin zero (AQP0) is a water channel expressed almost exclusively in fiber cells of the lens of the eye. (semanticscholar.org)
Glycerol and urea1
- Aquaporin 7 facilitates water, glycerol and urea transport. (novusbio.com)
Asparagine-proline-alanine1
- Aquaporins are characterized by presence of highly conserved asparagine proline alanine (NPA) boxes that are important for the formation of a water-permeating pore. (acris-antibodies.com)
Known as CHIP 282
- It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of Johns Hopkins University. (wikipedia.org)
- Also known as CHIP-28, aquaporin-1 is the major water channel of the red blood cells. (ndif.org)
Tumor2
- J. E. Towne, C. M. Krane, C. J. Bachurski, and A. G. Menon, "Tumor necrosis factor- α inhibits aquaporin 5 expression in mouse lung epithelial cells," The Journal of Biological Chemistry , vol. 276, no. 22, pp. 18657-18664, 2001. (hindawi.com)
- By closing these aquaporins, tumor growth and metastases could be inhibited. (innovations-report.com)
Antibodies1
- Findings show that overexpression of aquaporin 5 (AQP5 ) activated epithelial-mesenchymal transition ( EMT (show ITK Antibodies )) in colorectal cancer ( CRC (show CALR Antibodies )) cells. (antibodies-online.com)
Arabidopsis5
- Here, we establish a new link between aquaporin-dependent tissue hydraulics and auxin-regulated root development in Arabidopsis thaliana. (nih.gov)
- Aquaporins exhibit a characteristically high multiplicity of forms with for instance 35 members in Arabidopsis ( 4 , 5 ). (mcponline.org)
- 1 The PIPs with 13 members in Arabidopsis represent the most abundant aquaporins in the plasma membrane (PM) and can be further divided into two sequence homology groups ( At PIP1 and At PIP2). (mcponline.org)
- Im Rahmen dieser Arbeit sollte das zu dieser Familie gehƶrende Arabidopsis thaliana Aquaporin AtNIP1;1 funktionell charakterisiert werden. (tu-darmstadt.de)
- The aim of the thesis was the functional characterization of the Arabidopsis thaliana NIP-aquaporin AtNIP1;1. (tu-darmstadt.de)
Selectively2
- Aquaporins selectively conduct water molecules in and out of the cell, while preventing the passage of ions and other solutes. (wikipedia.org)
- Robert Stroud and colleagues, as reported in this issue of PLoS Biology, have now solved the structure of the water channel from Escherichia coli called aquaporin Z. This channel is especially interesting in that it selectively conducts only water at high rates. (innovations-report.com)
Homeostasis6
- Taken together, these recent reports suggest that water homeostasis in the brain is maintained by regulatory processes that, by control of aquaporin expression and distribution, induce and organize water movements. (nih.gov)
- Here, I will summarize our current knowledge of the involvement of aquaporin-formed pores and tight junctions in epidermal water homeostasis - as well as in other functions - and their putative roles in skin dryness. (springer.com)
- It seems intuitively obvious that plant water channels, aquaporins (AQP), ought to play a dynamic role in maintaining cellular water homeostasis under conditions that necessitate modifications in water flux. (plantphysiol.org)
- Aquaporins are selective water/glycerol channels involved in the maintenance of volume homeostasis and ionic/osmotic balance. (acris-antibodies.com)
- Because of its importance for normal water homeostasis and its involvement in many water balance disorders , aquaporin-2 , the predominant vasopressin - regulated water channel of the renal collecting duct , is discussed in detail. (ndif.org)
- Host water homeostasis and aquaporins (AQP) are essential during pathological conditions since they interfere with the cell cytoskeleton and signaling, and hereby affect cell morphology and functions. (diva-portal.org)
Functional2
- Finally, it is described how the interactions between aquaporins and copolymer matrixes or biological compounds offer an opportunity for the functional incorporation of aquaporins into new biotechnological advances. (frontiersin.org)
- We have performed the isolation, functional characterization, and expression analysis of aquaporins in roots and leaves of Helianthemum almeriense , in order to evaluate their roles in tolerance to water deficit. (apsnet.org)
Human9
- Bellemere G, Von Stetten O, Oddos T (2008) Retinoic acid increases aquaporin 3 expression in normal human skin. (springer.com)
- Boury-Jamot M, Sougrat R, Tailhardat M, Le Varlet B, Bonte F, Dumas M, Verbavatz JM (2006) Expression and function of aquaporins in human skin: Is aquaporin-3 just a glycerol transporter? (springer.com)
- The physiological importance of the aquaporin in human is perhaps most conspicuous in the kidney, where ~150-200 litres of water need to be reabsorbed from the primary urine each day, that is, aquaporin facilitated water transport is invoked when water rapidly must be retrieved from a body fluid. (environmental-expert.com)
- In this paper, we have screened a library of 1500 "fragments", i.e. , smaller than molecules used in HTS, against human aquaporin (hAQP1) using a thermal shift assay and surface plasmon resonance. (mdpi.com)
- To J, Torres J. Fragment Screening of Human Aquaporin 1. (mdpi.com)
- Aquaporin-4 is highly expressed in the human body primarily at the end-feet of astrocytes . (wikidoc.org)
- A replication-deficient, recombinant adenovirus encoding human aquaporin-1 with potential membrane water channel activity. (cancer.gov)
- A synthetic peptide corresponding to a sequence at the C-terminus of human Aquaporin 2. (thermofisher.com)
- Here, we show that a marine teleost orthologue of human aquaporin-8, termed Aqp8b, is rapidly phosphorylated and inserted into the inner mitochondrial membrane of SW-activated spermatozoa, where it facilitates H2O2 efflux from this compartment. (uib.no)
Kidney3
- Aquaporin-2 function is to reabsorb water from urine in the kidney. (proteopedia.org)
- The aquaporins are a family of water channels expressed in several water-transporting tissues, including the kidney. (sigmaaldrich.com)
- Aquaporin 1 forms a water-specific channel that is constitutively expressed at the PLASMA MEMBRANE of ERYTHROCYTES and KIDNEY TUBULES, PROXIMAL. (curehunter.com)
Urea3
- A subgroup of aquaporins called aquaglycerporins allow the passage of small solutes such as glycerol, urea, and ammonia. (proteopedia.org)
- Aquaporins have been classified into two subfamilies: i) strict aquaporins that only allow the passage of water and ii) the less selective aquaglyceroporins that transport water and other neutral solutes, such as glycerol, CO2 or urea. (ebscohost.com)
- Unlike other aquaporins, Xenopus oocytes expressing AQP11 in the plasma membrane failed to transport water, glycerol, urea, or ions. (acris-antibodies.com)
Suggests that aquaporins1
- We demonstrate that the aquaporin inhibitor mercuric chloride reduces the rate of vesicle swelling by an order of magnitude, which suggests that aquaporins facilitate the influx of water during vesicle deployment. (biologists.org)
Cells7
- Water moves through cells in an organized way, most rapidly in tissues that have aquaporin water channels. (wikipedia.org)
- Aquaporin 9 changes in pyramidal cells before and is expressed in astrocytes after delayed neuronal death in the ischemic hippocampal CA1 region of the gerbil. (ebi.ac.uk)
- 2020. "Insight into Salivary Gland Aquaporins" Cells 9, no. 6: 1547. (mdpi.com)
- Rodrigues O , Reshetnyak G , Grondin A , Saijo Y, Leonhardt N, Maurel C , Verdoucq L ā (2017) Aquaporins facilitate hydrogen peroxide entry into guard cells to mediate ABA- and pathogen-triggered stomatal closure . (inra.fr)
- Peter Agre discovered the first aquaporin in 1992 in red blood cells and was awarded the 2003 Nobel Prize. (innovations-report.com)
- Open aquaporins are necessary for cells to be able to move and form new blood vessels, which tumors are very dependent on to grow. (innovations-report.com)
- Gluco Contains Glycerol, regular include ins fit for engaging the generation of new Aquaporins in the layers of cells. (medicinesmexico.com)
AQP52
- This may improve characterization of acute respiratory distress syndrome and ultimately facilitate individualized care.Background The aquaporin-5 (AQP5) -1364A/C promoter single-nucleotide polymorphism is associated with an alteredAQP5 expression and mortality in sepsis. (medworm.com)
- Aquaporin 5 (AQP5) may be involved in NSCLC by promoting lungācancer initiation and progression. (spandidos-publications.com)
AQP91
- Aquaporin 7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. (novusbio.com)
Roles of aquaporins1
- Afzal Z, Howton TC, Sun Y, Mukhtar MS (2016) The roles of aquaporins in plant stress responses. (springer.com)
Intracellular2
- Eukaryotic aquaporins are frequently regulated post-translationally by gating, whereby the rate of flux through the channel is controlled, or by trafficking, whereby aquaporins are shuttled from intracellular storage sites to the plasma membrane. (lu.se)
- The combination of a high intracellular colonization, together with the fine-tuned expression of aquaporins could result in a morphophysiological adaptation of this symbiosis to drought conditions. (apsnet.org)
Mice5
- Mutations in aquaporin-0 in mice cause congenital cataracts. (proteopedia.org)
- Optical dysfunction of the crystalline lens in aquaporin-0-deficient mice. (uniprot.org)
- Amiry-Moghaddam M, Williamson A, Palomba M, Eid T, de Lanerolle NC, Nagelhus EA, Adams ME, Froehner SC, Agre P, Ottersen OP (2003) Delayed K+ clearance associated with aquaporin-4 mislocalization: phenotypic defects in brains of alpha-syntrophin-null mice. (springer.com)
- Bai C, Fukuda N, Song Y, Ma T, Matthay MA, Verkman AS (1999) Lung fluid transport in aquaporin-1 and aquaporin-4 knockout mice. (springer.com)
- Binder DK, Oshio K, Ma T, Verkman AS, Manley GT (2004) Increased seizure threshold in mice lacking aquaporin-4 water channels. (springer.com)
Facilitate1
- Aquaporins facilitate rapid, highly selective water transport, thus allowing the cell to regulate its volume and internal osmotic pressure according to hydrostatic and/or osmotic pressure differences across the cell membrane. (environmental-expert.com)
AQP33
- Aquaporin 7 and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. (novusbio.com)
- Relationship of aquaporins 3 (AQP3), 7 (AQP7), and 11 (AQP11) with boar sperm resilience to withstand freeze-thawing procedures. (sigmaaldrich.com)
- In this context, the hypothesis of this study was that aquaporins AQP3, AQP7, and AQP11 could be linked to boar sperm cryotolerance. (sigmaaldrich.com)
Ions1
- Unlike ion channels, aquaporins help prevent ions and other dissolved substances carrying electrical charge from entering the cell, as they only allow lone water molecules or certain uncharged solutes to pass through. (sciencephoto.com)
Peptide2
- Synthetic peptides corresponding to AQP7 (aquaporin 7) The peptide sequence was selected from the C terminal of AQP7. (fishersci.com)
- Synthetic peptide corresponding to amino acids 198-208 of rat aquaporin 1. (genetex.com)
Mammalian aquaporins1
- AQP 11 and 12 appear to be more distantly related to the other mammalian aquaporins and aquaglyceroporins. (ebi.ac.uk)
Pore3
- Aquaporins contain two tandem repeats, each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). (ebi.ac.uk)
- Gating of the central pore is controlled by cyclic guanosine monophosphate, a signaling nucleotide inside the cell, which induces a conformational change in one of the aquaporin loops (loop D). (phys.org)
- By modifying the pore-lining residue, or altering the length of loop D that gates the pore, we can shut down the ion conductivity completely, or engineer new aquaporins that can be opened more easily or have a higher ion conduction rate once open. (phys.org)
Osmotic1
- Secretin promotes osmotic water transport in rat cholangiocytes by incresing aquaporin-1 water channels in plasma membrane. (wiley.com)