Aquaporin 1
Aquaporin 5
Aquaporin 5 is a water-specific channel protein that is expressed primarily in alveolar, tracheal, and upper bronchial EPITHELIUM. It plays an important role in maintaining water HOMEOSTASIS in the LUNGS and may also regulate release of SALIVA and TEARS in the SALIVARY GLANDS and the LACRIMAL GLAND.
Aquaporin 3
Aquaporin 4
Aquaporins
Aquaporin 2
Aquaporin 6
Water
Mercuric Chloride
Osmosis
Aquaglyceroporins
Blood Group Antigens
Water-Electrolyte Balance
Glycerol
Permeability
Cell Membrane Permeability
Plant Transpiration
Kidney Tubules, Collecting
Kidney Concentrating Ability
Diabetes Insipidus, Nephrogenic
A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
Plant Proteins
Ion Channels
Neuromyelitis Optica
Polyuria
Biological Transport
Xenopus laevis
Osmotic Pressure
Oocytes
Antidiuretic Agents
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tulipa
Vapor Pressure
Amino Acid Sequence
Cistaceae
Plant Roots
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Cell Membrane
Membrane Proteins
Lens, Crystalline
Gene Expression Regulation, Plant
Renal Agents
Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.
Osmolar Concentration
Vasopressins
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Immunohistochemistry
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Glomeromycota
Microscopy, Electron, Scanning Transmission
A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.
Salivary Glands
Deamino Arginine Vasopressin
Propylene Glycol
Mesophyll Cells
Mesembryanthemum
Kidney Medulla
Kidney
Submandibular Gland
One of two salivary glands in the neck, located in the space bound by the two bellies of the digastric muscle and the angle of the mandible. It discharges through the submandibular duct. The secretory units are predominantly serous although a few mucous alveoli, some with serous demilunes, occur. (Stedman, 25th ed)
Receptors, Vasopressin
Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.
Droughts
Astrocytes
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Reverse Transcriptase Polymerase Chain Reaction
Xenopus
Mercury
A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
Gene Expression
Rats, Sprague-Dawley
Spinacia oleracea
Glycerol Kinase
An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyacetone and L-glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. EC 2.7.1.30.
Protein Transport
Pichia
Rats, Brattleboro
Plant Stomata
Proteolipids
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Blotting, Western
Saline Solution, Hypertonic
Antimony Potassium Tartrate
Plant Leaves
Base Sequence
Malpighian Tubules
Glial Fibrillary Acidic Protein
Sequence Homology, Amino Acid
RNA, Complementary
Immunoblotting
Microscopy, Immunoelectron
Models, Molecular
Solute Carrier Family 12, Member 1
4-Chloromercuribenzenesulfonate
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
DNA Primers
Urea
Hypertonic Solutions
Arabidopsis
Gene Expression Regulation
Morula
Sodium-Potassium-Chloride Symporters
DNA, Complementary
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Quercus
Cloning, Molecular
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Zea mays
Molecular Dynamics Simulation
Hydroxyethyl Starch Derivatives
Long-term regulation of aquaporins in the kidney. (1/216)
The discovery of the aquaporin family of water channels has greatly improved our understanding of how water crosses epithelial cells, particularly in the kidney. The study of the mechanisms involved in the regulation of collecting duct water permeability, in particular, has advanced very rapidly since the identification and characterization of aquaporin-2 (AQP2) in 1993. One of the more surprising findings has been the dramatic long-term changes that are seen in the abundance of this protein, as well as the recognition that these changes represent a way of modulating the acute antidiuretic effects of vasopressin. Furthermore, such changes seem to be of etiological and pathological significance in a number of clinical disorders of water balance. This review focuses on the various conditions in which AQP2 expression is altered (either increased or decreased) and on what this can tell us about the signals and mechanisms controlling these changes. Ultimately, this may be of great value in the clinical management of water balance disorders. Evidence is also now beginning to emerge that there are similar changes in the expression of other renal aquaporins, which had previously been thought to provide an essentially constitutive water permeability pathway, suggesting that they too should be considered as regulatory factors in the control of body water balance. (+info)Vasopressin regulates apical targeting of aquaporin-2 but not of UT1 urea transporter in renal collecting duct. (2/216)
In the renal inner medullary collecting duct (IMCD), vasopressin regulates two key transporters, namely aquaporin-2 (AQP2) and the vasopressin-regulated urea transporter (VRUT). Both are present in intracellular vesicles as well as the apical plasma membrane. Short-term regulation of AQP2 has been demonstrated to occur by vasopressin-induced trafficking of AQP2-containing vesicles to the apical plasma membrane. Here, we have carried out studies to determine whether short-term regulation of VRUT occurs by a similar process. Cell surface labeling with NHS-LC-biotin in rat IMCD suspensions revealed that vasopressin causes a dose-dependent increase in the amount of AQP2 labeled at the cell surface, whereas VRUT labeled at the cell surface did not increase in response to vasopressin. Immunoperoxidase labeling of inner medullary thin sections from Brattleboro rats treated with 1-desamino-8-D-arginine vasopressin (DDAVP) for 20 min revealed dramatic translocation of AQP2 to the apical region of the cell, with no change in the cellular distribution of VRUT. In addition, differential centrifugation of inner medullary homogenates from Brattleboro rats treated with DDAVP for 60 min revealed a marked depletion of AQP2 from the low-density membrane fraction (enriched in intracellular vesicles) but did not alter the quantity of VRUT in this fraction. Finally, AQP2-containing vesicles immunoisolated from a low-density membrane fraction from renal inner medulla did not contain immunoreactive VRUT. Thus vasopressin-mediated regulation of AQP2, but not of VRUT, depends on regulated vesicular trafficking to the plasma membrane. (+info)An impaired routing of wild-type aquaporin-2 after tetramerization with an aquaporin-2 mutant explains dominant nephrogenic diabetes insipidus. (3/216)
Autosomal recessive and dominant nephrogenic diabetes insipidus (NDI), a disease in which the kidney is unable to concentrate urine in response to vasopressin, are caused by mutations in the aquaporin-2 (AQP2) gene. Missense AQP2 proteins in recessive NDI have been shown to be retarded in the endoplasmic reticulum, whereas AQP2-E258K, an AQP2 mutant in dominant NDI, was retained in the Golgi complex. In this study, we identified the molecular mechanisms underlying recessive and dominant NDI. Sucrose gradient centrifugation of rat and human kidney proteins and subsequent immunoblotting revealed that AQP2 forms homotetramers. When expressed in oocytes, wild-type AQP2 and AQP2-E258K also formed homotetramers, whereas AQP2-R187C, a mutant in recessive NDI, was expressed as a monomer. Upon co-injection, AQP2-E258K, but not AQP2-R187C, was able to heterotetramerize with wild-type AQP2. Since an AQP monomer is the functional unit and AQP2-E258K is a functional but misrouted water channel, heterotetramerization of AQP2-E258K with wild-type AQP2 and inhibition of further routing of this complex to the plasma membrane is the cause of dominant NDI. This case of NDI is the first example of a dominant disease in which the 'loss-of-function' phenotype is caused by an impaired routing rather than impaired function of the wild-type protein. (+info)Aquaporin-6: An intracellular vesicle water channel protein in renal epithelia. (4/216)
All characterized mammalian aquaporins (AQPs) are localized to plasma membranes where they function chiefly to mediate water transport across cells. Here we show that AQP6 is localized exclusively in intracellular membranes in renal epithelia. By using a polyclonal antibody to the C terminus of AQP6, immunoblots revealed a major 30-kDa band in membranes from rat renal cortex and medulla. Endoglycosidase treatment demonstrated presence of an intracellular high mannose glycan on each subunit. Sequential ultracentrifugation of rat kidney homogenates confirmed that AQP6 resides predominantly in vesicular fractions, and immunohistochemical and immunoelectron microscopic studies confirmed that >98% of AQP6 is located in intracellular membrane vesicles. In glomeruli, AQP6 is present in membrane vesicles within podocyte cell bodies and foot processes. In proximal tubules, AQP6 is also abundant in membrane vesicles within the subapical compartment of segment 2 and segment 3 cells, but was not detected in the brush border or basolateral membranes. In collecting duct, AQP6 resides in intracellular membrane vesicles in apical, mid, and basolateral cytoplasm of type A intercalated cells, but was not observed in the plasma membrane. Unlike other members of the AQP family, the unique distribution in intracellular membrane vesicles in multiple types of renal epithelia indicates that AQP6 is not simply involved in transcellular fluid absorption. Moreover, our studies predict that AQP6 participates in distinct physiological functions such as glomerular filtration, tubular endocytosis, and acid-base metabolism. (+info)The Cre/loxP system and gene targeting in the kidney. (5/216)
The Cre/loxP and Flp/FRT systems mediate site-specific DNA recombination and are being increasingly utilized to study gene function in vivo. These systems allow targeted gene disruption in a single cell type in vivo, thereby permitting study of the physiological and pathophysiological impact of a given gene product derived from a particular cell type. In the kidney, the Cre/loxP system has been employed to achieve gene deletion selectively within principal cells of the collecting duct. Disruption of target genes in the collecting duct, such as endothelin-1 or polycystic kidney disease-1 (PKD1), could lead to important insights into the biological roles of these gene products. With selection of the appropriate renal cell-specific promoters, these recombination systems could be used to target gene disruption to virtually any renal cell type. Although transgenic studies utilizing these recombination systems are promising, they are in their relative infancy and can be time consuming and expensive and yield unanticipated results. It is anticipated that continued experience with these systems will produce an important tool for analyzing gene function in renal health and disease. (+info)Urinary excretion of aquaporin-2 in rat is mediated by a vasopressin-dependent apical pathway. (6/216)
Clinical studies have shown that aquaporin-2 (AQP2), the vasopressin-regulated water channel, is excreted in the urine, and that the excretion increases in response to vasopressin. However, the cellular mechanisms involved in AQP2 excretion are unknown, and it is unknown whether the excretion correlates with AQP2 levels in kidney or levels in the apical plasma membrane. The present study was undertaken to clarify these issues. Immunoblotting of rat urine samples revealed significant excretion of AQP2, whereas AQP3, being a basolateral aquaporin in the same cells, was undetectable. Thus, there was a nonproportional excretion of AQP2 and AQP3 (compared with kidney levels), indicating that AQP2 is excreted predominantly via a selective apical pathway and not by whole cell shedding. Urinary AQP2 was associated with small vesicles, membrane fragments, and multivesicular bodies as determined by immunoelectron microscopy and negative staining techniques. In rats with normal water supply, daily urinary excretion of AQP2 was 3.9+/-0.9% (n = 6) of total kidney expression. Treatment with desmopressin acetate subcutaneously caused a fourfold increase in urinary excretion of AQP2 during 8 h. Forty-eight hours of thirsting, known to increase endogenous vasopressin secretion, resulted in a three-fold increase in kidney AQP2 levels but urinary excretion increased ninefold to 15+/-3% (n = 6) of AQP2 in kidney of thirsted rats. Moreover, rats that were thirsted for 48 h and subsequently allowed free access to water for 24 h produced a decrease in urinary AQP2 excretion to 38+/-15% (n = 6) of that during thirsting. In Brattleboro rats or lithium-treated normal rats completely lacking vasopressin action, and hence having extremely low levels of AQP2 in the apical plasma membrane, AQP2 was undetectable in urine. Thus, conditions with known altered vasopressin levels and altered levels of AQP2 in the apical plasma membrane were associated with corresponding major changes in AQP2 urine excretion. In contrast, in such conditions, kidney AQP2 levels and urinary AQP2 excretion did not show a proportional relationship. (+info)Effects of missense mutations on rat aquaporin-2 in LLC-PK1 porcine kidney cells. (7/216)
BACKGROUND: Mutations in the aquaporin-2 (AQP2) gene have been found in families with nephrogenic diabetes insipidus (NDI), but the pathophysiological mechanisms of how mutant AQP2 causes the disease are still not clear. METHODS: Wild-type (WT) AQP2 and four mutants-T126M, A147T, R187C, and S216P-were transiently expressed in LLC-PK1 cells. The osmotic water permeability of LLC-PK1 cells expressing AQP2 mutants was determined by stopped-flow light-scattering microphotometry. Cell surface expression, subcellular localization, and effects of vasopressin stimulation were examined by surface biotin labeling and confocal immunohistochemistry. RESULTS: The osmotic water permeability (Pf) of cells expressing WT increased significantly after vasopressin treatment, whereas the Pf of cells expressing T126M A147T, R187C, and S216P was not significantly different from that of the control even after vasopressin stimulation. Confocal immunohistochemistry demonstrated distribution of WT and A147T in early/recycling endosomal compartments and vasopressin-responsive translocation and surface expression. In contrast, stainings of T126M, R187C, and S216P were similar to that of Grp78, indicating that these mutants were misassembled and retarded in the endoplasmic reticulum. CONCLUSION: Our results indicated that the intracellular distribution and vasopressin-regulated trafficking of A147T is intact, in contrast to the other three mutants, of which both were impaired. Thus, it is conceivable that the disruption of the AQP2 channel function accounts for the pathogenesis of A147T NDI, whereas trafficking defects account for that of the other types, suggesting that the pathophysiology of AQP2-related NDI is heterogeneous. (+info)Lack of vasopressin-independent upregulation of AQP-2 gene expression in homozygous Brattleboro rats. (8/216)
Arginine vasopressin (AVP) plays an important role in the expression of aquaporin (AQP-2) in the collecting duct. The present study was undertaken to determine whether there is an AVP-independent regulation of AQP-2 gene expression in homozygous Brattleboro rats in which endogenous AVP is absent. Exogenous administration of 1-deamino-8-D-AVP produced an antidiuresis and expressed AQP-2 mRNA and AQP-2 protein in the renal medulla of the homozygous Brattleboro rats. Twelve hours of water deprivation produced severe dehydration in the homozygous Brattleboro rats, such that urinary osmolality increased from 200 to 649 mosmol/kgH(2)O. However, no increase in AQP-2 mRNA expression was observed after this dehydration, and the medullary tissue content and urinary excretion of AQP-2 also remained unchanged. Increases in AQP-2 mRNA expression and AQP-2 protein were evident in Long-Evans rats after 64 h of water deprivation, with a severity of dehydration almost equal to the 12-h dehydrated, homozygous Brattleboro rats. These results indicate the lack of an AVP-independent mechanism for upregulating AQP-2 mRNA expression in renal collecting duct cells. (+info)
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KEGG PATHWAY: Vasopressin-regulated water reabsorption - Mus musculus (mouse)
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Nephrogenic Diabetes Insipidus - Genitourinary Disorders - Merck Manuals Professional Edition
What does kidney medulla mean?
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EGFR-mediated expression of aquaporin-3 is involved in human s...
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Revas h 50/12.5mg tablet 15s
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Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) drinking water channels - Role of adrenergic...
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dna testing kits for paternity - Aquaporin and water channels
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Mankhwala 7 Opambana Othandiza Khansa Yammapapo-Yavomerezedwa ndi FDA
Major intrinsic proteins
The MIP superfamily includes three subfamilies: aquaporins, aquaglyceroporins and S-aquaporins. The aquaporins (AQPs) are water ... Aquaporin-1 (Aqp1) from the human red blood cell has been solved by electron crystallography to 3.8 Å resolution (PDB: 1FQY). ... Aquaporins generally have the NPA motif in both halves, the glycerol facilitators generally have an NPA motif in the first ... Roles of aquaporins in human cancer have been reviewed as have their folding pathways. AQPs may act as transmembrane ...
FAM177A1
IntAct reports physical interactions between FAM117A1 and these other human proteins: Aquaporin-6 Caspase 6 DPM3 ELOVL4 FATE1 ...
List of MeSH codes (D12.776.157)
... aquaporin 1 MeSH D12.776.157.530.400.500.040.437 - aquaporin 2 MeSH D12.776.157.530.400.500.040.468 - aquaporin 4 MeSH D12.776. ... aquaporins MeSH D12.776.157.530.400.500.040.249 - aquaglyceroporins MeSH D12.776.157.530.400.500.040.249.500 - aquaporin 3 MeSH ... 157.530.400.500.040.484 - aquaporin 5 MeSH D12.776.157.530.400.500.520 - voltage-dependent anion channels MeSH D12.776.157.530. ... D12.776.157.530.400.500.040.249.750 - aquaporin 6 MeSH D12.776.157.530.400.500.040.374 - ...
List of MeSH codes (D12.776.543)
... aquaporin 1 MeSH D12.776.543.550.425.730.040.437 - aquaporin 2 MeSH D12.776.543.550.425.730.040.468 - aquaporin 4 MeSH D12.776. ... aquaporin 1 MeSH D12.776.543.585.400.730.040.530 - aquaporin 2 MeSH D12.776.543.585.400.730.040.577 - aquaporin 4 MeSH D12.776. ... aquaporins MeSH D12.776.543.550.425.730.040.249 - aquaglyceroporins MeSH D12.776.543.550.425.730.040.249.500 - aquaporin 3 MeSH ... aquaporins MeSH D12.776.543.585.400.730.040.249 - aquaglyceroporins MeSH D12.776.543.585.400.730.040.249.500 - aquaporin 3 MeSH ...
Vasopressin
Aquaporins allow water to move down their osmotic gradient and out of the nephron, increasing the amount of water re-absorbed ... Vasopressin, acting through cAMP, also increases transcription of the aquaporin-2 gene, thus increasing the total number of ... This occurs through increased transcription and insertion of water channels (Aquaporin-2) into the apical membrane of ... Wilson JL, Miranda CA, Knepper MA (2013). "Vasopressin and the Regulation of Aquaporin-2". Clinical and Experimental Nephrology ...
Neuromyelitis optica spectrum disorder
In 2005 they identified the aquaporin 4 protein as the target of the disease, and developed the first in-house test to aid in ... In more than 80% of cases, IgG autoantibodies against aquaporin-4 (anti-AQP4+) are the cause, and in 10-40% of the remaining ... In more than 80% of cases, NMO is caused by immunoglobulin G autoantibodies to aquaporin 4 (anti-AQP4), the most abundant water ... Some authors propose to use the name "autoimmune aquaporin-4 channelopathy" for these diseases, while others prefer a more ...
Anti-AQP4 disease
... s, are a group of diseases characterized by auto-antibodies against aquaporin 4. After the discovery of anti- ... Pittock SJ, Lucchinetti CF (February 2016). "Neuromyelitis optica and the evolving spectrum of autoimmune aquaporin-4 ... "autoimmune aquaporin-4 channelopathy" for these diseases, while others prefer a more generic term "AQP4-astrocytopathy" that ... "Clinical Relevance of Serum Aquaporin-4 Antibody Levels in Neuromyelitis Optica". Neurochemical Research. 38 (5): 997-1001. doi ...
Aquaporin
This results in aquaporin-2 containing vesicles to increase water uptake and return to circulation. Mutation of the aquaporin 2 ... The gating of an aquaporin is carried out by an interaction between a gating mechanism and the aquaporin, which causes a 3D ... It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of ... There have been two clear examples of diseases identified as resulting from mutations in aquaporins: Mutations in the aquaporin ...
Satralizumab
NMOSD can be associated with antibodies that bind to a protein called aquaporin-4 (AQP4). Binding of the anti-AQP4 antibody ... people who are anti-aquaporin-4 or AQP4 antibody-positive. NMOSD is a rare autoimmune disease of the central nervous system ... of 116 participants with NMOSD who were anti-aquaporin-4 (AQP4) antibody positive. The trials were conducted at 62 sites in the ... including the formation of pathological autoantibodies against aquaporin-4 (AQP4), and the permeability of the blood-brain ...
Aquaporin-3
Aquaporin 3 is expressed more in atopic eczema. Recent studies indicate that aquaporin 3 is overexpressed in many types of ... Sasaki S, Ishibashi K, Marumo F (1998). "Aquaporin-2 and -3: representatives of two subgroups of the aquaporin family ... Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal ... 2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line". J. Membr. Biol. ...
Aquaporin-7
... and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin ... Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene. Aquaporins/major intrinsic proteins (MIP) are a ... "Entrez Gene: AQP7 aquaporin 7". Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated ... Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. ...
Aquaporin-9
... (AQP-9) is a protein that in humans is encoded by the AQP9 gene. The aquaporins/major intrinsic protein are a ... Aquaporin-9 has greater sequence similarity with AQP3 and AQP7 and they may be a subfamily. Aquaporin-9 allows passage of a ... "Entrez Gene: AQP9 aquaporin 9". Ishibashi K, Kuwahara M, Gu Y, et al. (1998). "Cloning and functional expression of a new ... 2003). "Aquaporin-9 is expressed in a mucus-secreting goblet cell subset in the small intestine". FEBS Lett. 540 (1-3): 157-62 ...
Aquaporin-1
Aquaporin+1 at the US National Library of Medicine Medical Subject Headings (MeSH) Gallery of Aquaporin Simulations Human AQP1 ... "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)". Knepper MA (July 1994). "The aquaporin family of molecular water channels ... The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Aquaporin ... Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene. AQP-1 is a widely expressed water channel, whose ...
Aquaporin-6
The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family ... Aquaporin-6, (AQP-6) also known as kidney-specific aquaporin is a protein in humans that is encoded by the AQP6 gene. ... "Entrez Gene: Aquaporin 6, kidney specific". Retrieved 2012-04-10. Human AQP6 genome location and AQP6 gene details page in the ... Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M (Oct 2002). "Characterization of aquaporin-6 as a nitrate channel in ...
Aquaporin-5
... (AQP-5) is a protein that in humans is encoded by the AQP5 gene. Aquaporin-5 (AQP-5) is a water channel protein. ... Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 ... "Entrez Gene: AQP5 aquaporin 5". Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): ... 2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008- ...
Aquaporin-4
The expression of aquaporin 4 is reliant on the disease stage of TBI. In an acute stage of TBI, the lack of aquaporin 4 causes ... Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. AQP-4 belongs to the aquaporin ... Aquaporin-4 is the most common aquaporin in the brain, spinal cord, and optic nerve. It is highly expressed in the human body ... Aquaporin-4 is essential in the formation of memory as well as synaptic plasticity. Other performances that aquaporin-4 is ...
Aquaporin-2
It is the only aquaporin regulated by vasopressin. The basic job of aquaporin 2 is to reabsorb water from the urine while its ... This aquaporin is also regulated by food intake. Fasting reduces expression of this aquaporin independently of vasopressin. ... so the aquaporin 2 can be used by the cell. This aquaporin is regulated in two ways by the peptide hormone vasopressin: short- ... Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular ...
Acidocalcisome
... including aquaporins, ATPases and Ca2+/H+ and Na+/H+ antiporters. They may be the only cellular organelle that has been ... Their membranes are 6 nm thick and contain a number of protein pumps and antiporters, ...
SKIP
"The inositol Inpp5k 5-phosphatase affects osmoregulation through the vasopressin-aquaporin 2 pathway in the collecting system ... 462 (6): 871-83. doi:10.1007/s00424-011-1028-0. PMID 21938401. S2CID 27923688. Drayer AL, Pesesse X, De Smedt F, Communi D, ...
Primary polydipsia
June 1999). "Urinary excretion of aquaporin-2 water channel differentiates psychogenic polydipsia from central diabetes ... PPD occurs in between 6% and 20% of psychiatric inpatients. It may also be found in people with developmental disorders, such ... 84 (6): 2235-2237. doi:10.1210/jcem.84.6.5715. PMID 10372737. "Psychogenic polydipsia - Symptoms, diagnosis and treatment , BMJ ... 35 (6): 408-419. doi:10.1016/0006-3223(94)90008-6. PMID 8018788. S2CID 21962668. Hutcheon, Donald. "Psychogenic Polydipsia ( ...
PLD2
Zheng X, Bollinger Bollag W (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane ... 276 (52): 48840-6. doi:10.1074/jbc.M104276200. PMID 11687572. Lee S, Kim JH, Lee CS, Kim JH, Kim Y, Heo K, et al. (February ... 121 (6): 1487-95. doi:10.1111/j.1523-1747.2003.12614.x. PMID 14675200. Czarny M, Fiucci G, Lavie Y, Banno Y, Nozawa Y, ...
Caveolin 1
Zheng X, Bollinger Bollag W (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane ... 121 (6): 1487-95. doi:10.1111/j.1523-1747.2003.12614.x. PMID 14675200. Czarny M, Fiucci G, Lavie Y, Banno Y, Nozawa Y, ... 56 (3): 355-6. doi:10.1006/geno.1998.5723. PMID 10087206. "Entrez Gene: CAV1 caveolin 1, caveolae protein, 22kDa". Li S, ... 63 (6): 1578-87. doi:10.1086/302172. PMC 1377628. PMID 9837809. Razani B, Schlegel A, Liu J, Lisanti MP (August 2001). " ...
Neurohypophysial hormone
"Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2". Nephrol. Dial. Transplant. 19 ( ... 10): 2480-6. doi:10.1093/ndt/gfh413. PMID 15280526. Michel G, Acher R, Chauvet J, Ouedraogo Y, Chou J, Chait BT (1995). "A new ...
Vasopressin receptor 2
Robben JH, Knoers NV, Deen PM (Aug 2006). "Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water ... Ishikawa SE (Feb 2002). "[Nephrogenic diabetes insipidus associated with mutations of vasopressin V2 receptors and aquaporin-2 ... 2 (2): 103-6. doi:10.1038/ng1092-103. PMID 1303257. S2CID 26492862. van den Ouweland AM, Dreesen JC, Verdijk M, Knoers NV, ... 3 (9): 1685-6. doi:10.1093/hmg/3.9.1685. PMID 7833930. Birnbaumer M, Gilbert S, Rosenthal W (Jul 1994). "An extracellular ...
GATA6
... also indicated in proper lung development by controlling the late differentiation stages of alveolar epithelium and aquaporin-5 ... Transcription factor GATA-6, also known as GATA-binding factor 6 (GATA6), is protein that in humans is encoded by the GATA6 ... 54 (4): 542-6. doi:10.1203/01.PDR.0000081295.56529.E9. PMID 12867597. Liu C, Ikegami M, Stahlman MT, Dey CR, Whitsett JA (2003 ... Furthermore, GATA-6 has been linked to the production of LIF, a cytokine that encourages proliferation of endodermal embryonic ...
Luca Regli
Badaut, J.; Regli, L. (2004-01-01). "Distribution and possible roles of aquaporin 9 in the brain". Neuroscience. Brain Water ... "Distribution of Aquaporin 9 in the adult rat brain: Preferential expression in catecholaminergic neurons and in glial cells". ... "Astrocyte-specific expression of aquaporin-9 in mouse brain is increased after transient focal cerebral ischemia". Journal of ... 10 (6): 1871-1874. doi:10.1158/1078-0432.CCR-03-0384. ISSN 1078-0432. PMID 15041700. S2CID 12027992. "Trends in Neurovascular ...
Urea transporter
Yang B, Verkman AS (September 2002). "Analysis of double knockout mice lacking aquaporin-1 and urea transporter UT-B. Evidence ... 277 (39): 36782-6. doi:10.1074/jbc.M206948200. PMID 12133842. Collins D, Winter DC, Hogan AM, Schirmer L, Baird AW, Stewart GS ...
Blood-Spinal Cord Barrier
Nicaise C, Soyfoo MS, Authelet M, De Decker R, Bataveljic D, Delporte C, Pochet R (December 2008). "Aquaporin‐4 Overexpression ... They release secretory compounds that influence the phenotype of endothelial cells and express aquaporin and potassium channels ... 13(6):3163-3166. doi: 10.3892/etm.2017.4410. Epub 2017 Apr 28. PMID 28588671; PMCID: PMC5450788. Uchida Y, Sumiya T, Tachikawa ... Frontiers in neuroengineering, 6, 7. https://doi.org/10.3389/fneng.2013.00007 Bouhassira D, Attal N. (2018) "Emerging therapies ...
Daf-2
... elegans by downregulating DAF-16/FOXO activity and aquaporin gene expression". Cell Metabolism. 10 (5): 379-91. doi:10.1016/j. ... 15 (6): 672-86. doi:10.1101/gad.867301. PMC 312654. PMID 11274053. Lee SJ, Murphy CT, Kenyon C (November 2009). "Glucose ... 277 (5328): 942-6. doi:10.1126/science.277.5328.942. PMID 9252323. Kenyon C (February 2005). "The plasticity of aging: insights ...
Randy Wayne (biologist)
Am J Bot 84:1522-1529 Christophe Maurel (June 1997). "AQUAPORINS AND WATER PERMEABILITY OF PLANT MEMBRANES". Annual Review of ... Wayne's work preceded the molecular identification of aquaporins in plant cells. It is generally believed that the ... Kaldenhoff, R., Bertl, A., Otto, B., Moshelion, M. and Uehlein, N. (2007). "Characterization of Plant Aquaporins". Osmosensing ... S2CID 15863712.{{cite journal}}: CS1 maint: multiple names: authors list (link) Maurel, Christophe (1997). "Aquaporins and ...
TRPV
aquaporin 5, calmodulin, pacsin 3 2 TRPV5 calcium-selective TRP channel intestine, kidney, placenta 100:1 TRPV6 annexin II / ... doi:10.1124/pr.57.4.6. PMID 16382100. S2CID 17936350.. *^ Venkatachalam K, Montell C (2007). "TRP channels". Annual Review of ... 978-94-007-0264-6. .. *^ Vennekens R, Owsianik G, Nilius B (2008). "Vanilloid transient receptor potential cation channels: an ... How TRP subunits recognize and interact with each other is still poorly understood.[6][7] ...
Calmodulin
It does this by binding various targets in the cell including a large number of enzymes, ion channels, aquaporins and other ... 6: 809. doi:10.3389/fpls.2015.00809. ISSN 1664-462X. PMC 4604306. PMID 26528296.. ... Binding of Ca2+ by the EF-hands causes an opening of the N- and C-domains, which exposes hydrophobic target-binding surfaces.[6 ... 6] but remains largely disordered in solution.[9] The C-domain has a higher binding affinity for Ca2+ than the N-domain.[10][11 ...
Ligand-gated ion channel
279 (19): 19383-6. doi:10.1074/jbc.R300035200. PMID 15023997.. *^ a b c Langlhofer G, Villmann C (2016-01-01). "The ... P2X6. P2X7 Clinical relevance[edit]. Ligand-gated ion channels are likely to be the major site at which anaesthetic agents and ... doi:10.1186/gb-2004-6-1-r4. PMC 549065. PMID 15642096.. *^ Jaiteh M, Taly A, Hénin J (2016). "Evolution of Pentameric Ligand- ... GLUK6, GluR6, GluR-6, EAA4. GLUK7, GluR7, GluR-7, EAA5. GLUK1, KA1, KA-1, EAA1. GLUK2, KA2, KA-2, EAA2 ...
Nephron
Aquaporins are membrane proteins that selectively conduct water molecules while preventing the passage of ions and other ... ADH affects the function of aquaporins, resulting in the reabsorption of water molecules as it passes through the collecting ... Retrieved March 6, 2007. Hook JB, Goldstein RS (1993). Toxicology of the Kidney. Raven Press. p. 8. ISBN 0-88167-885-6. Nosek ... ISBN 978-0-07-184268-6. "The Kidney Tubule I: Urine Production". Ecology & Evolutionary Biology - University of Colorado at ...
Biometal (biology)
Potassium absorption has a positive correlation with aquaporins and the uptake of water in plant cells via cell membrane ... ISBN 978-0-7303-9202-6. OCLC 1268517745. Wilck N, Balogh A, Markó L, Bartolomaeus H, Müller DN (September 2019). "The role of ...
Syntrophin, alpha 1
... has been shown to interact with Dystrophin, Nav1.1 and Nav1.5, and Aquaporin 4. GRCh38: Ensembl release 89 ... "In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4". J. Cell Biol ... "Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein". Proc. Natl. Acad. Sci. U.S.A. 98 (24): ... "Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein". Proc. Natl. Acad. Sci. U.S.A. 98 (24): ...
Jane Osbourn
Shanahan, CM (1999). "Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across ... 1999 Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes ... 6 March 2017. Vaughan, Tristan J.; Williams, Andrew J.; Pritchard, Kevin; Osbourn, Jane K.; Pope, Anthony R.; Earnshaw, John C ... 35 (6): 948-949. doi:10.1016/j.ccell.2019.05.010. PMID 31185215. Chodorge, M (3 December 2018). "Engineering of a GLP-1 ...
Mir-708 microRNA precursor family
"Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive ... 192 (6): 919-27. doi:10.1083/jcb.201010055. PMC 3063143. PMID 21402790. Robin TP, Smith A, McKinsey E, Reaves L, Jedlicka P, ... 6 (4): e18501. doi:10.1371/journal.pone.0018501. PMC 3075242. PMID 21532750. Oliveira JC, Brassesco MS, Morales AG, Pezuk JA, ...
Primary effusion lymphoma
Marlar S, Jensen HH, Login FH, Nejsum LN (October 2017). "Aquaporin-3 in Cancer". International Journal of Molecular Sciences. ... aquaporin 3, is a water channel that when overexpressed is thought to promote the progression and spread of various types of ... 35 (1): 94-6. doi:10.1093/ageing/afj009. PMID 16364944. Kubota T, Sasaki Y, Shiozawa E, Takimoto M, Hishima T, Chong JM ( ... IL-6 which, while not often expressed, induces these cells to produce VEGF, a cytokine that feeds back on these cells to ...
Kangaroo rat
To help conserve water they produce very concentrated urine, via a process apparently associated with expression of aquaporin 1 ... 302 (6): R720-R726. doi:10.1152/ajpregu.00549.2011. PMC 3774486. PMID 22237592. Morgan, K. R.; Price, M. V. (1992-12-01). " ... 73 (6): 2260-2272. doi:10.2307/1941473. JSTOR 1941473. Jenkins, S. H.; Rothstein, A.; Green, W. C. H. (December 1995). "Food ... Offspring remain in the mound for 1-6 more months in the maternal caches. Family Heteromyidae Subfamily Dipodomyinae Dipodomys ...
VAMP2
... possible role in aquaporin-2 trafficking". The Journal of Clinical Investigation. 98 (4): 906-13. doi:10.1172/JCI118873. PMC ... 272 (4): 2520-6. doi:10.1074/jbc.272.4.2520. PMID 8999968. Hao JC, Salem N, Peng XR, Kelly RB, Bennett MK (Mar 1997). "Effect ... 254 (1): 21-6. doi:10.1006/bbrc.1998.9876. PMID 9920726. Valdez AC, Cabaniols JP, Brown MJ, Roche PA (Mar 1999). "Syntaxin 11 ... 112 (6): 845-54. doi:10.1242/jcs.112.6.845. PMID 10036234. Margittai M, Otto H, Jahn R (Mar 1999). "A stable interaction ...
Ralf Kaldenhoff
Aquaporin tetramer composition modifies the function of tobacco aquaporins. Journal of Biological Chemistry, 2010. 285(41): p. ... He is known for his work on the aquaporin protein class, where he detected facilitated diffusion of CO2 in plant tissue and ... Kaldenhoff was one of the first scientists to describe plant aquaporins. He initially accomplished to analyse the function and ... For the first time, Kaldenhoff could provide evidence that an aquaporin molecule could conduct CO₂. Kaldenhoff also worked on ...
Vasopressin receptor antagonist
Congenital nephrogenic diabetes insipidus (NDI) may result from V2R or aquaporin-2 (AQP2) mutations. Exogenously administered ... doi:10.1016/S0079-6123(02)39017-4. ISBN 978-0-444-50982-6. PMID 12436936. Lemmens-Gruber, R; Kamyar, M (2006). "Vasopressin ... ISBN 978-0-08-092046-7. L. Kovács; B. Lichardus (6 December 2012). Vasopressin: Disturbed Secretion and Its Effects. Springer ...
Epithelial sodium channel
... aquaporins or Na/K-ATPase. In sweat glands, CFTR is responsible for the reabsorption of chloride in the sweat duct. Sodium ions ... 147 (6): 733-748. doi:10.1007/s00418-016-1535-3. PMID 28130590. S2CID 8504408. Enuka Y, Hanukoglu I, Edelheit O, Vaknine H, ... 23 (4 Pt 1): 763-6. doi:10.1016/0190-9622(90)70285-p. PMID 2229513. Hanukoglu I (February 2017). "ASIC and ENaC type sodium ...
Myelin oligodendrocyte glycoprotein
The presence of anti-MOG autoantibodies has been associated with the following conditions Most cases of aquaporin-4- ... 63 (6): 2353-6. doi:10.1046/j.1471-4159.1994.63062353.x. PMID 7964757. S2CID 2788720. Pham-Dinh D, Mattei MG, Nussbaum JL, ... 102 (6): 1853-62. doi:10.1111/j.1471-4159.2007.04687.x. PMC 2156149. PMID 17573820. Breithaupt C, Schubart A, Zander H, Skerra ... The dssp secondary structure of the protein is 6% helical and 43% beta sheet: there are three short helical segments and ten ...
SNAP23
... colocalization with aquaporin-2 in collecting duct vesicles". The American Journal of Physiology. 275 (5 Pt 2): F752-60. doi: ... 9 (6): 1437-48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185. Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H ... 9 (6): 1437-48. doi:10.1091/mbc.9.6.1437. PMC 25366. PMID 9614185. Foster LJ, Yeung B, Mohtashami M, Ross K, Trimble WS, Klip A ... 112 (6): 845-54. doi:10.1242/jcs.112.6.845. PMID 10036234. Imai A, Nashida T, Yoshie S, Shimomura H (Aug 2003). "Intracellular ...
List of autoimmune diseases
"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel". Journal of Experimental Medicine. 202 (4 ... "Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression". Archives of Neurology. 63 (7): 964-968. ... 1 (8634): 363-6. doi:10.1016/S0140-6736(89)91733-9. PMID 2563515. S2CID 30147670. Singal A, Janiga JJ, Bossenbroek NM, Lim HW ( ... 6 (2): 59-83. doi:10.1016/S1525-1578(10)60493-X. PMC 1867474. PMID 15096561. Hyland KV, Engman DM (2006). "Further thoughts on ...
Congenital cataract
... or Aquaporin, cytoskeletal structural proteins, paired-like homeodomain transcription factor 3 (PITX3), avian ... with an estimated prevalence of 1 to 6 cases per 10,000 live births. Basic and clinical science course (2011-2012). Pediatric ... a visually significant unilateral congenital cataract should be detected and removed before age 6 weeks, and visually ...
Aphid
"A water-specific aquaporin involved in aphid osmoregulation". Insect Biochemistry and Molecular Biology. 39 (1): 1-10. doi: ... 8 (6): 596-603. doi:10.1111/j.1461-0248.2005.00754.x. ISSN 1461-023X. Ryabov, E. V.; Keane, G.; Naish, N.; Evered, C.; ... Retrieved 6 February 2018. Gibson, R. W.; Pickett, J. A. (1983). "Wild potato repels aphids by release of aphid alarm pheromone ... Retrieved 6 February 2018. Evans, D. A.; Medler, J. T. (1966-12-01). "Improved Method of Using Yellow-Pan Aphid Traps1". ...
Arsenic biochemistry
... enters the cells though aquaporins 7 and 9, which is a type of aquaglyceroporin. Arsenic (V) compounds use phosphate ... 14 (6): 651-656. doi:10.1021/tx000264z. PMID 11409934. Lin, Lin S.; Thomas, D. J.; Cullen, W. R.; Wang, C.; Styblo, M.; Del ... 6 (10): 1421-1426. doi:10.1093/carcin/6.10.1421. PMID 3840060. Kessel, M; Liu, S.X (2002). "Arsenic induces oxidative DNA ... Westheimer, F.H. (6 June 1987). "Why nature chose phosphates". Science. 235 (4793): 1173-1178 (see pp. 1175-1176). Bibcode: ...
Cerebrospinal fluid
This creates osmotic pressure and draws water into CSF, facilitated by aquaporins. Chloride, with a negative charge, moves with ... and specific antibodies such as aquaporin-4 may be tested for to assist in the diagnosis of autoimmune conditions. A lumbar ... 128 (6): 309-16. doi:10.1016/j.anorl.2011.03.002. PMID 22100360. Orešković D, Klarica M (2014). "A new look at cerebrospinal ... 68 (6): 1103-8. PMID 14524396. Archived from the original on 2008-05-15. Retrieved 2009-03-05. Hocking G, Wildsmith JA (October ...
Bone marrow
Only mature blood cells contain the membrane proteins, such as aquaporin and glycophorin, that are required to attach to and ... 36 (6): 1911-1930. doi:10.1148/rg.2016160056. ISSN 0271-5333. PMID 27726743. Poulton, T B; Murphy, W D; Duerk, J L; Chapek, C C ... 161 (6): 1217-21. doi:10.2214/ajr.161.6.8249729. PMID 8249729. Shah, LM; Hanrahan, CJ (December 2011). "MRI of spinal bone ... 197 (6): 1298-308. doi:10.2214/ajr.11.7005. PMID 22109283. S2CID 20115888. Vande Berg, BC; Lecouvet, FE; Galant, C; Maldague, ...
Inflammatory demyelinating diseases of the central nervous system
July 2009). "Aquaporin-4 autoimmune syndrome and anti-aquaporin-4 antibody-negative opticospinal multiple sclerosis in Japanese ... The presence of anti-MOG autoantibodies has been associated with the following conditions Some cases of aquaporin-4- ... Vojdani A, Mukherjee PS, Berookhim J, Kharrazian D (2015). "Detection of Antibodies against Human and Plant Aquaporins in ... Tzartos JS, Stergiou C, Kilidireas K, Zisimopoulou P, Thomaidis T, Tzartos SJ (2013). "Anti-aquaporin-1 autoantibodies in ...
Diabetes insipidus
... it acts on proteins called aquaporins and more specifically aquaporin 2 in the following cascade. When released, ADH binds to ... Nephrogenic DI results from lack of aquaporin channels in the distal collecting duct (decreased surface expression and ... stimulating translocation of the aquaporin 2 channel stored in the cytoplasm of the distal convoluted tubules and collecting ... 25 (6): 777-779. doi:10.1007/s11102-022-01276-2. ISSN 1573-7403. Rubin AL (2011). Diabetes For Dummies (3 ed.). John Wiley & ...
Aquaporin-6 - Wikipedia
The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. Aquaporins are a family ... Aquaporin-6, (AQP-6) also known as kidney-specific aquaporin is a protein in humans that is encoded by the AQP6 gene. ... "Entrez Gene: Aquaporin 6, kidney specific". Retrieved 2012-04-10. Human AQP6 genome location and AQP6 gene details page in the ... Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M (Oct 2002). "Characterization of aquaporin-6 as a nitrate channel in ...
Aquaporin 6 Antibody | R31204 NSJ Bioreagents
This highly specific Aquaporin 6 antibody is suitable for use in WB, IHC-P and is guaranteed to work as stated on the product ... Aquaporin 6 is a protein in humans that is encoded by the AQP6 gene. The aquaporins (AQPs) are a family of water-transporting ... After reconstitution, the Aquaporin 6 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at - ... Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. Single-channel analyses have ...
Aquaporins in Melanocytic and Nonmelanocytic Skin Tumors
This study investigated the role of aquaporin 1 and aquaporin 3 in the pathobiology of skin cancers. Might they have potential ... Objectives: Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the ... Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors. ... Aquaporin (AQP) expression has been identified in various skin structures.[1] Specifically, AQP1 has been found in the ...
Structural mechanism of plant aquaporin gating | Nature
Living cells regulate the movement of water via pores in the cell membrane called aquaporins. In a study of plant aquaporin, ... Here we report the X-ray structure of the spinach plasma membrane aquaporin SoPIP2;1 in its closed conformation at 2.1 Å ... These results reveal a molecular gating mechanism which appears conserved throughout all plant plasma membrane aquaporins. ... Plants counteract fluctuations in water supply by regulating all aquaporins in the cell plasma membrane. Channel closure ...
Aquaporin water channels - From atomic structure to clinical medicine<...
At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ... At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ... At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ... At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ...
Analysis from the Phase 3 N-MOmentum Study Demonstrates the Effectiveness of UPLIZNA® (inebilizumab-cdon) Among Neuromyelitis...
Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum. Ann Neurol. 2016;79(5):775-783. ... Neuromyelitis optica spectrum disorders with and without aquaporin 4 antibody: Characterization, differential diagnosis, and ... in adult patients who are anti-aquaporin-4 (AQP4) antibody positive. ... 2019;6(4):e580. * Kimbrough DJ, et al. Treatment of neuromyelitis optica: review and recommendations. Mult Scler Relat Disord. ...
AQP2 gene: MedlinePlus Genetics
The AQP2 gene provides instructions for making a protein called aquaporin 2. Learn about this gene and related health ... If aquaporin 2 water channels are not inserted into the membrane of collecting duct cells, the kidneys are unable to respond to ... The aquaporin 2 water channel plays an essential role in maintaining the bodys water balance. The placement of these channels ... Most of the known AQP2 gene mutations cause the aquaporin 2 protein to be misfolded into an incorrect 3-dimensional shape. The ...
Minisymposia - ASCB | ASCB
Aquaporin-7 Is a Metabolic Sensor That Regulates Response to Cellular Stress in Breast Cancer. C. Dai, V. Charlestin, M. Wang, ... N. Willy1, J. Ferguson1, S. Silahli1, C. Cakez2, F. Hasan1, H. Chang3, A. Travesset4, R. Zandi5, S. Li5, D. Li6, E. Betzig7, E ... 6:05 pm M17 A New Hi-C Method Reveals the Conformation of Sister Chromatids. M. Mitter1, C. Gasser2, Z. Takacs1, R. Stocsits3, ... 6:05 pm M7 An Integrated Undergraduate Steam Course: The Art and Science of Cell Death. S. Walsh1, A. Stewart2, J. Almond2, S. ...
Search
Aquaporins/metabolism (2). Amino Acid Substitution (1)Aquaporins/genetics (1)Ion Channels/chemistry (1)Ion Channels/genetics (1 ... Heterotetrameric composition of aquaporin-4 water channels. Agre, Peter; Nielsen, S; Christensen, B. M.; Neely, JD (American ... Conversion of aquaporin 6 from an anion channel to a water-selective channel by a single amino acid substitution Yasui, Masato ... Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. Single-channel analyses have ...
Piezo channels in the urinary system | Experimental & Molecular Medicine
... facilitating aquaporin-2 lipid membrane targeting to accelerate water reabsorption74. However, this hypothesis still needs to ... 2b). THU1-6 cells at the end of the blades are highly curved; consequently, the presence of the lever-like apparatus is also ... 6,7,8,9,10, resulting in a wide range of biological effects. Given the crucial physiological and pathological roles of MSCs in ... on the medullary principal cells of the kidney might increase cAMP production by improving the activity of adenylyl cyclase-6, ...
LOINC LG50124-3 - Aquaporin 4 water channel Ab.IgG|PrThr|Pt|CSF
LOINC Code LG50124-3 Aquaporin 4 water channel Ab.IgG,PrThr,Pt,CSF ... LG50124-3Aquaporin 4 water channel Ab.IgG,. PrThr,. Pt,. CSFActive. Basic Attributes. Version First Released. Pending promotion ... Aquaporin 4 water channel IgG Ab [Presence] in Cerebral spinal fluid by Cell binding immunofluorescent assay. ... Aquaporin 4 water channel IgG Ab [Presence] in Cerebral spinal fluid Archetype. ...
Aquaporins
The Georges Morel 2018 prize was awarded to Christophe Maurel, deputy director of BPMP and head of the Aquaporin team. This ... 2017) Aquaporins facilitate hydrogen peroxide entry into guard cells to mediate ABA- and pathogen-triggered stomatal closure. ... 2019) Oscillating aquaporin phosphorylations and 14-3-3 proteins mediate the circadian regulation of leaf hydraulics. Plant ... 2016) Novel aquaporin regulatory mechanisms revealed by interactomics. Mol. Cell. Proteomics, 15(11):3473-3487 ...
Code System Concept
Characterizing pediatric-onset neuromyelitis optica spectrum disorder in British Columbia | British Columbia Medical Journal
... aquaporin-4 immunoglobulin or AQP4-IgG (also known as NMO-IgG). Differentiating NMOSD from multiple sclerosis has important ... and often involves the autoantibody aquaporin-4 immunoglobulin or AQP4-IgG (also known as NMO-IgG).[6,7] This serum ... 6. Lim BC, Hwang H, Kim KJ, et al. Relapsing demyelinating CNS disease in a Korean pediatric population: Multiple sclerosis ... autoantibody targets the aquaporin-4 water channel and induces a series of biological events that result in tissue inflammation ...
LOINC LG17408-2 - Aquaporin 4 water channel Ab.IgG|PrThr|Pt|ANYBldSerPl
LOINC Code LG17408-2 Aquaporin 4 water channel Ab.IgG,PrThr,Pt,ANYBldSerPl ... LG17408-2Aquaporin 4 water channel Ab.IgG,. PrThr,. Pt,. ANYBldSerPlActive. Basic Attributes. Version First Released. Pending ... Aquaporin 4 water channel IgG Ab [Presence] in Serum or Plasma by Immune stain. ... Aquaporin 4 water channel IgG Ab [Presence] in Serum by Cell binding immunofluorescent assay. ...
Expression of aquaporin-4 water channels in rat cholangiocytes<...
Expression of aquaporin-4 water channels in rat cholangiocytes. Raúl A. Marinelli, Linh D. Pham, Pamela S. Tietz, Nicholas F. ... Expression of aquaporin-4 water channels in rat cholangiocytes. / Marinelli, Raúl A.; Pham, Linh D.; Tietz, Pamela S. et al. ... Expression of aquaporin-4 water channels in rat cholangiocytes. In: Hepatology. 2000 ; Vol. 31, No. 6. pp. 1313-1317. ... Marinelli, R. A., Pham, L. D., Tietz, P. S., & LaRusso, N. F. (2000). Expression of aquaporin-4 water channels in rat ...
Appendix 8: Expression of Genes Encoding for Aquaporins, Connexins and Intermediate Filaments - DocsBay
Expression of genes encoding for aquaporins, connexins and intermediate filaments. Genes were ranked based on the RPKM (Reads ... Aquaporins / Aqp7 / Aquaporin 7 / 0.17 / 0.01 / 8.89 / 0.17 / 53.69 / 0.041499125. Aqp1 / Aquaporin 1 / 0.10 / 27.66 / 7.54 / ... Aqp3 / Aquaporin 3 / 1.29 / 0.00 / 40.61 / 0.00 / Inf / 1.03E-10. Aqp8 / Aquaporin 8 / 0.53 / 6.35 / 18.88 / 91.13 / -4.83 / ... Aqp2 / Aquaporin 2 / 0.07 / 0.00 / 2.72 / 0.00 / Inf / 0.524607013. Aqp6 / Aquaporin 6 / 0.02 / 0.00 / 1.03 / 0.00 / Inf / ...
A versatile 3D culture model facilitates monitoring of astrocytes undergoing reactive gliosis - Open Research Online
SCOP 1.67: Class f: Membrane and cell surface proteins and peptides
f.19: Aquaporin-like [81339] (1 superfamily). core: 8 helices, 2 short helices are surrounded by 6 long transmembrane helices. ... f.6: Leukocidin-like [56958] (1 superfamily). subunit fold contains beta-sandwich of Ig-like (grerk-key) topology and a beta- ... membrane all-alpha fold; 6-helical "barrel" with internal binding cavity. *. f.43: Chlorophyll a-b binding protein [103510] (1 ... core: multihelical; consists of three transmembrane regions of 2, 2 and 6 helices, separated by cytoplasmic domains. ...
Hepatorenal Syndrome: Background, Pathophysiology, Etiology
Aquaporin-1 and aquaporin-2 urinary excretion in cirrhosis: Relationship with ascites and hepatorenal syndrome. Hepatology. ... 18] Type 2 HRS has a median survival of 3-6 months. A retrospective cohort study in the United States found a 36.9% mortality ... These patients are often diuretic-resistant, with a median survival of 3-6 months. Although this is markedly longer than HRS- ...
Colonic gene expression in conventional and germ-free mice with a focus on the butyrate receptor GPR109A and the butyrate...
UMLS. CSP-HL7-ICD9CM-NCI-NDFRT-RXNORM - Terms starting with 'Q' - MEDINDEX.AM
Aquaporins in Melanocytic and Nonmelanocytic Skin Tumors
This study investigated the role of aquaporin 1 and aquaporin 3 in the pathobiology of skin cancers. Might they have potential ... Objectives: Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the ... Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors. ... Aquaporin (AQP) expression has been identified in various skin structures.[1] Specifically, AQP1 has been found in the ...
Inebilizumab-cdon reduces neuromyelitis optica spectrum disorder attack severity
Epidemiology of aquaporin-4 autoimmunity and neuromyelitis optica spectrum. Ann Neurol. 2016;79(5):775-783. ... Neuromyelitis optica spectrum disorders with and without aquaporin 4 antibody: Characterization, differential diagnosis, and ... in adult patients who are anti-aquaporin-4 (AQP4) antibody positive. ... is the first and only B-cell-depleting agent approved by the FDA for the treatment of NMOSD in adults who are anti-aquaporin-4 ...
Peter Spégel | Lund University Diabetes Centre
GSE9006 HEALTHY VS TYPE 1 DIABETES PBMC 4MONTH POST DX DN
Plant Aquaporins
Yaneff A, Vitali V, Amodeo G (2015) PIP1 aquaporins: intrinsec water channels or PIP2 aquaporin modulators? FEBS Letters 589: ... Verkman AS (2013) Aquaporins. Curr Biol. 23(2): R52-R55. doi: 10.1016/j.cub.2012.11.025. 10.1016/j.cub.2012.11.025. 3590904. ... Ding L, Uehlein N, Kaldenhoff R, Guo S, Zhu Y, Kai L (2019) Aquaporin PIP2;1 affects water transport and root growth in rice ( ... 3. Agre P, Sasaki S, Chrispeels MJ (1993) Aquaporins: a family of water channel proteins. Am J Physiol. 265 (3 Pt 2):F461. doi: ...
ProteinsAQP1ProteinAQP620212016AQP2NMOSD20022019AQP4-IgGSerumAqp5GenesAQP3MembranesExpression2022Aqp9Glycerol2017Neuromyelitis optica spectrum disorderTumorAntibodiesBritish Journal of DermatologyPermeabilityLocalizationAQPsNephrogenic diabetesAutoantibodyCharacterizationBiochem Soc TAstrocyticKidneyPatientsTransmembraneELISAMultiple sclerosisDiseasesMutationsMechanismsPhysiologyAmino acid seqUreaYEASTRenal waterAcinar cellsPhosphorylationMetabolismSecretionCellsInterleukin
Proteins14
- Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). (wikipedia.org)
- The aquaporins (AQPs) are a family of water-transporting proteins that facilitate osmotically driven water movement across cell plasma membranes. (nsjbio.com)
- Johansson, I., Larsson, C., Ek, B. & Kjellbom, P. The major integral proteins of spinach leaf plasma membranes are putative aquaporins and are phosphorylated in response to Ca 2+ and apoplastic water potential. (nature.com)
- The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) water channel protein. (elsevier.com)
- Aquaporin (AQP) water channel proteins are tetrameric assemblies of individually active approximately 30 kDa subunits. (jhu.edu)
- Functional analysis of naturally occurring mutations in the vasopressin type-2 receptor and aquaporin-2 have increased the insight into the structure and function of both proteins and have led to substantial progress in understanding the cellular mechanisms underlying the concentrating ability of the kidney. (rug.nl)
- These processes are linked to the regulation of aquaporins, membrane channel proteins that facilitate the transport of water across cell membranes. (inra.fr)
- 3. Agre P, Sasaki S, Chrispeels MJ (1993) Aquaporins: a family of water channel proteins. (sciendo.com)
- 5. Benga G (2012) On the definition, nomenclature and classification of water channel proteins (aquaporins and relatives). (sciendo.com)
- Aquaporins (AQP's) are six-pass transmembrane proteins that form channels in membranes. (reactome.org)
- Basco D, Nicchia GP, D'Alessandro A, Zolla L, Svelto M, Frigeri A. Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling. (ucdenver.edu)
- Aquaporin-5 (AQP5) is one of a large family of proteins on cell membranes. (reviewofoptometry.com)
- The family of proteins to which aquaporins belong sometimes goes by the name integral membrane proteins (IMP) or major intrinsic proteins (MIP). (reviewofoptometry.com)
- Aquaporins (AQPs) are proteins that transport water across cell membranes. (healthcarentsickcare.com)
AQP14
- Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. (medscape.com)
- We recently reported that secretin induces the exocytic insertion of functional aquaporin-1 water channels (AQP1) into the apical membrane of cholangiocytes and proposed that this was a key process in ductal bile secretion. (elsevier.com)
- Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). (reactome.org)
- Therefore, the goal of our study was to determine the level of expression of the water channel aquaporin 1 (AQP1) during cardiac development and in the anaemic fetal sheep heart. (elsevier.com)
Protein12
- Aquaporin-6, (AQP-6) also known as kidney-specific aquaporin is a protein in humans that is encoded by the AQP6 gene. (wikipedia.org)
- The protein encoded by this gene is an aquaporin protein, which functions as a water channel in cells. (wikipedia.org)
- Aquaporin 6 is a protein in humans that is encoded by the AQP6 gene. (nsjbio.com)
- The AQP2 gene provides instructions for making a protein called aquaporin 2. (medlineplus.gov)
- Most of the known AQP2 gene mutations cause the aquaporin 2 protein to be misfolded into an incorrect 3-dimensional shape. (medlineplus.gov)
- The protein is called aquaporin and it sits within cell membranes. (blogspot.com)
- Aquaporin-9 protein is the primary route of hepatocyte glycerol uptake for glycerol gluconeogenesis in mice. (mpg.de)
- Bien CG, Schänzer A, Dargvainiene J, Dogan-Onugoren M, Woermann F, Strickler A. Co-occurrence of antibodies against dipeptidyl-peptidase-like protein-6 and aquaporin-4 during a case of paraneoplastic encephalitis. (laborkrone.de)
- Linkage analysis showed that the Cat Tohm mutation is located on mouse chromosome 10, close to the gene for aquaporin-0 (Aqp0), which encodes a membrane protein that is expressed specifically in lens fiber cells. (elsevier.com)
- The remainder include heat shock transcription factor-4 ( HSF4 ), aquaporin-0, v-maf musculoaponeurotic fibrosarcoma oncogene homolog, paired-like homeodomain 3, beaded filament structural protein-2, chromatin modifying protein and lens intrinsic membrane protein 2 ( 4 ). (spandidos-publications.com)
- In addition to the aquaporins, you will find additional protein family members whose users display regionally unique patterns of manifestation along the renal tubule and may, therefore, be involved in regulating functionally important cellular activities inside a segment-specific manner. (chinamicrospine.com)
- Aquaporin 4 may be connected to the dystrophin-associated protein complex. (wikimili.com)
AQP61
- Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. (nsjbio.com)
20211
- Biomedical journal 2021 12 44 (6 Suppl 1): S93-S100. (cdc.gov)
20163
- 2016 Dec ;12(6):3863-3872. (greenmedinfo.com)
- Sci Rep . 2016;6:31413. (ualg.pt)
- 2016 Aug 6;22:970-89. (ucdavis.edu)
AQP23
- Vasopressin regulates renal water homeostasis via Aquaporins by regulating the permeability of the epithelium through activation of a signaling cascade leading to the phosphorylation of AQP2 and its translocation from intracellular vesicles to the apical membrane of collecting duct cells. (reactome.org)
- The results demonstrated positive selection acting on angiotensin converting enzyme (ACE), angiotensinogen (AGT), SLC14A2, and aquaporin 2 (AQP2). (biomedcentral.com)
- ADM significantly decreased aquaporin-2 (AQP2) phosphorylation at Serine 256 (pS256) and increased it at Serine 261 (pS261). (emory.edu)
NMOSD15
- UPLIZNA is indicated for the treatment of neuromyelitis optica spectrum disorder (NMOSD) in adult patients who are anti-aquaporin-4 (AQP4) antibody positive. (businesswire.com)
- Neuromyelitis optica spectrum disorder (NMOSD) has emerged as a disorder distinct from multiple sclerosis, largely due to the discovery in 2004 of a novel disease marker, aquaporin-4 immunoglobulin or AQP4-IgG (also known as NMO-IgG). (bcmj.org)
- NMOSD affects more females than males,[ 5,6 ] is seen in mixed ethnic populations, and often involves the autoantibody aquaporin-4 immunoglobulin or AQP4-IgG (also known as NMO-IgG). (bcmj.org)
- According to the company, inebilizumab-cdon is the first and only B-cell-depleting agent approved by the FDA for the treatment of NMOSD in adults who are anti-aquaporin-4 (AQP4) antibody positive. (modernretina.com)
- The objectives of this phase Ib study are to evaluate the efficacy, safety, pharmacokinetics, pharmacodynamics and immunogenic profiles of B001 in subjects with aquaporin-4 antibody (AQP4-IgG) positive NMOSD. (medifind.com)
- Recognizing the predictors of disease relapses in patients with anti-aquaporin-4 antibody (AQP4-ab)-positive neuromyelitis optica spectrum disorder (NMOSD) is essential for individualized treatment strategy. (figshare.com)
- [6] NMOSD produces significant axonal loss associated with perivascular lymphocytic infiltration and vascular proliferation. (eyewiki.org)
- [6] Necrosis in NMOSD usually involves both gray and white matter, which is distinct from multiple sclerosis. (eyewiki.org)
- [6] The pathophysiology of NMOSD mainly involves the humoral immune system. (eyewiki.org)
- Eculizumab, a monoclonal antibody that targets C5, is the first drug specifically approved by the US Food and Drug Administration (FDA) for adults with neuromyelitis optica spectrum disorder (NMOSD) who are seropositive for anti-aquaporin-4 (AQP4) antibody. (medscape.com)
- A first drug for the therapy of anti-aquaporin-4 (AQP4) antibody seropositive NMOSD patients has been approved in 2019: the C5 complement inhibitor eculizumab. (mdc-berlin.de)
- METHODS: An international cohort of women with aquaporin-4 antibody-positive NMOSD and ≥1 pregnancy was studied retrospectively. (ox.ac.uk)
- Detection of IgG anti-Aquaporin-4 (AQP4) in serum of individuals with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). transmission made reliable detection impossible. (welbourneprimary.com)
- Abstract Purpose To emphasize physio-pathological, clinical and prognosis differences between conditions causing serious and sometimes very similar clinical manifestations: anti-aquaporin-4 (AQP4) and DNM1 anti-myelin oligodendrocyte glycoprotein (MOG) antibodies related diseases, and seronegative NMOSD (neuromyelitis optica spectrum disorders). (seatra.org)
- 5]. This pleomorphic phenotype led to the concept of NMO spectrum disorders (NMOSD) [6]. (seatra.org)
20022
20192
- 15. Ding L, Uehlein N, Kaldenhoff R, Guo S, Zhu Y, Kai L (2019) Aquaporin PIP2;1 affects water transport and root growth in rice ( Oryza sativa L.). Plant Physiology and Biochemistry 139:152-160. (sciendo.com)
- Journal of Arid Land , 2019, 11(6): 866-879. (xjegi.com)
AQP4-IgG2
- [6] NMO is characterized by a disease specific IgG antibody against the astrocytic aquaporin 4 (AQP4) water channel (also known as the aquaporin-4 autoantibody (anti-AQP4 or AQP4-IgG). (eyewiki.org)
- It is distinguished from other demyelinating conditions by the presence of AQP4-IgG and serum aquaporin 4 (AQP4), found mainly in the blood-brain barrier. (360qikan.com)
Serum9
- 6,7 ] This serum autoantibody targets the aquaporin-4 water channel and induces a series of biological events that result in tissue inflammation, demyelination, and edema. (bcmj.org)
- Keeping his skin as hydrated as possible, he uses Dercent's Hydrating Aquaporin Serum. (koreaboo.com)
- Description: A sandwich ELISA kit for detection of Aquaporin 5 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
- The human IL-6 ELISA kit is suitable for the quantitative determination of human IL-6 in a wide range of sample types, including serum, plasma, cell culture supernates, tissue homogenates, and urine. (cusabio.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Glucose 6 Phosphate Isomerase (GPI) in serum, plasma and other biological fluids. (kits-elisa.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Mannosyl Alpha-1,6-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase (MGAT5) in serum, plasma, tissue homogenates and other biological fluids. (wildpalm.net)
- Description: A sandwich ELISA kit for detection of Mannosyl Alpha-1,6-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (wildpalm.net)
- Description: A sandwich ELISA kit for detection of Transient Receptor Potential Cation Channel Subfamily C, Member 6 from Human in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (therabio.org)
- In her serum, antibodies targeting the water channel aquaporin-4 are found. (osmosis.org)
Aqp53
- Description: A sandwich quantitative ELISA assay kit for detection of Human Aquaporin 5 (AQP5) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Aquaporin 5 (AQP5) in saliva, tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Aquaporin 5 (AQP5) in samples from saliva, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (myelisakit.com)
Genes3
- Among these genes, the crystallin and connexin genes appear to be the most commonly associated with congenital cataracts, whereas approximately half of the mutations belong to the crystalline genes ( CRYAA, CRYAB, CRYBA1 / A3 , CRYBB1 , CRYBB2 , CRYBA4 , CRYGC , CRYGD and CRYGS ) and a quarter of the mutations belong to connexin genes ( GJA3 and GJA8 ) ( 6 ). (spandidos-publications.com)
- Defects in aquaporin genes can cause disease. (reviewofoptometry.com)
- Additionally, the urea absorption process will be analyzed through the expression profile of aquaporin genes VgPIP1,5 and VgTIP2 when the plants will be treated with urea or equivalent amounts of nitrogen in the form of ammonium. (fapesp.br)
AQP34
- [ 6 ] Marked AQP3 expression has also been found in human squamous cell carcinoma [ 7 ] and in cell lines with epidermoid differentiation. (medscape.com)
- Após a exposição à radiação UVA, HaCaT responde com aumento na liberação de IL-6, TNF-α e COX-2, internalização/redução de AQP3 da membrana, redução na liberação de MMP-2 e 9, aumento na liberação de MMP-1 e na produção de ERO. (usp.br)
- Quando expostos à radiação UVB, HaCaT aumenta a liberação de IL-6 e COX-2, promove internalização/redução de AQP3 na membrana e redução na liberação de MMP-2 e 9. (usp.br)
- Specifically, aquaporin 3 (AQP3) the most abundant aquaporin found in skin has been reported to play a key role in skin hydration, elasticity and barrier repair. (princeton.edu)
Membranes3
- Diagram illustrating the structural mechanism of aquaporin gating in plant plasma membranes. (nature.com)
- The company, Aquaporin A/S , is currently working on developing membranes that will desalinate water by a very different mechanism from the current traditional RO methods, and possibly with smaller energy footprint. (blogspot.com)
- ABC transporters are ubiquitous in all kingdoms of life and facilitate the transport of a large variety of substrates across membranes using ATP hydrolysis as energy source [6, 7]. (barcelonashop.shop)
Expression13
- Aquaporin (AQP) expression has been identified in various skin structures. (medscape.com)
- 4. Balarynová J, Danihlik J, Fellner M (2018) Changes in plasma membrane aquaporin gene expression under osmotic stress and blue light in tomato. (sciendo.com)
- Decreased Expression of Aquaporins in Otitis Media: What About Chronic Otitis Media? (e-ceo.org)
- Increased Expression of Aquaporin 9 in Trophoblast From Gestational Diabetic Patients. (ivi-rmainnovation.com)
- Dupuis C , Robert A, Gerard L, Morelle J, Laterre P, Hantson P, Trikha A. Nephrogenic Diabetes Insipidus following an Off-Label Administration of Sevoflurane for Prolonged Sedation in a COVID-19 Patient and Possible Influence on Aquaporin-2 Renal Expression. (wjgnet.com)
- N-Acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191): an anti-inflammatory molecule that increases the expression of the aquaglyceroporin, aquaporin-3, in human keratinocytes. (princeton.edu)
- To investigate further the previously reported hydrating potential of IPC compounds, SIG-1191 was tested for its ability to modulate aquaporin expression. (princeton.edu)
- Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate-induced diarrhoea model. (medicaljournalshouse.com)
- J. BADAUT, S. ASHWAL, L.REGLI, B. TONE, H.R. TIAN, A.OBENAUS (2007) Temporal and Regional Evolution of Aquaporin 4 Expression and Magnetic Resonance Imaging in a Rat Pup Model of Neonatal Stroke. (llu.edu)
- M DE CASTRO RIBEIRO, L HIRT, J BOGOUSSLAVSKY, L REGLI and J BADAUT (2006) Time course of edema formation and brain aquaporin expression after transient focal cerebral ischemia in mice. (llu.edu)
- J. BADAUT, J.M. PETIT, J.F. BRUNET, P.J. MAGISTRETTI, C. CHARRIAUT-MARLANGUE AND L. REGLI (2004) Distribution of Aquaporin 9 in the adult rat brain: preferential expression in catecholaminergic neurons and in glial cells. (llu.edu)
- Recent surveys obtained in our laboratory also suggested increased expression of VgPIP1,5 and VgTIP2, two aquaporins cloned in this species when the plants were kept in urea. (fapesp.br)
- Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis. (ki.se)
20222
- 2022 May 6. (ivi-rmainnovation.com)
- 2022 Volume 12 Issue 6. (ivi-rmainnovation.com)
Aqp92
- During Transport of glycerol from adipocytes to the liver by Aquaporins, glycerol generated by triglyceride hydrolysis is exported from adipocytes by AQP7 and is imported into liver cells via AQP9. (reactome.org)
- Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats. (llu.edu)
Glycerol4
- At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus glycerol (aquaglyceroporins). (elsevier.com)
- Nodulin-26 aquaporin and glycerol facilitator, NIP (de Paula Santos Martins et al. (lbl.gov)
- Hg2+-inhibitable aquaporin, AqpM (transports both water and glycerol as well as CO2) (Kozono et al. (lbl.gov)
- What makes an aquaporin a glycerol channel? (illinois.edu)
20173
- 2017). Here, aquaporins contribute to the signalling pathway of this stress hormone by facilitating the entry of hydrogen peroxide in the guard cell. (inra.fr)
- 16. Fox AR, Maistriaux LC, Chaumont F (2017) Toward understanding of the high number of plant aquaporin isoforms and multiple regulation mechanisms. (sciendo.com)
- Experimental and therapeutic medicine 2017 Dec 14 (6): 6017-6021. (cdc.gov)
Neuromyelitis optica spectrum disorder3
- Whole-exome sequencing reveals the major genetic factors contributing to neuromyelitis optica spectrum disorder in Chinese patients with aquaporin 4-IgG seropositivity. (cdc.gov)
- Neuromyelitis optica spectrum disorder is an autoimmune astrocytopathy of the CNS with secondary demyelination, which can be associated with a specific auto-antibody against the antigen aquaporin-4 (AQP4) in 50-90% of cases ( 4 ). (frontiersin.org)
- Pregnancy outcomes in aquaporin-4-positive neuromyelitis optica spectrum disorder. (ox.ac.uk)
Tumor2
- Here, we demonstrate a new IPC compound, N-acetylglutaminoyl-S-farnesyl-L-cysteine (SIG-1191), which inhibits UVB-induced inflammation blocking pro-inflammatory cytokine interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) production. (princeton.edu)
- Bolstering the case for inflammation, a 2005 paper reported that the tear fluid of keratoconus patients contained inflammatory mediators, such as interleukin-6, tumor necrosis factor-alpha (TNF-a) and matrix mettaloproteinase-9 (MMP-9). (reviewofoptometry.com)
Antibodies1
- Children aged three months to two years, who are no longer provided with maternal antibodies derived from pas- sive immunization and do not possess mature immune systems, are highly sus- Online platform Binary option cash back Sandnes Aquaporins and Water Transport in the Cornea Alan S. (forexsignal300.com)
British Journal of Dermatology1
- British Journal of Dermatology, vol.131(6): 856-861. (whioce.com)
Permeability1
- 6. Benga G (2013) Comparative studies of water permeability of red blood cells from humans and over 30 animal species: an overview of 20 years of collaboration with Philip Kuchel. (sciendo.com)
Localization1
- Localization and ordering of lipids around Aquaporin-0: Proteinand lipid mobility effects. (mpg.de)
AQPs1
- While rules of Na+ homeostasis requires the orchestrated work of multiple Na+ transporters along the nephron, water IACS-9571 reabsorption across the tubular epithelium is almost entirely dependent on the activity of water channels, aquaporins (AQPs). (chinamicrospine.com)
Nephrogenic diabetes3
- Loonen AJ, Knoers NV, van Os CH, Deen PM. Aquaporin 2 mutations in nephrogenic diabetes insipidus. (medlineplus.gov)
- Robben JH, Knoers NV, Deen PM. Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus. (medlineplus.gov)
- In humans, mutations in the aquaporin-2 gene lead to hereditary nephrogenic diabetes insipidus. (reviewofoptometry.com)
Autoantibody1
- Aquaporin-4 and MOG autoantibody discovery in idiopathic transverse myelitis epidemiology. (bmj.com)
Characterization1
- Characterization of aquaporin-6 as a nitrate channel in mammalian cells. (wikipedia.org)
Biochem Soc T1
- Biochem Soc Trans (2005) 33 (6): 1316-1318. (silverchair.com)
Astrocytic2
- Aquaporin-4 (Aqp4), an astrocytic transmembrane water channel, is an important molecular contributor to cerebral edema formation. (biomedcentral.com)
- J.BADAUT, S. ASHWAL, A ADAMI, B TONE, B RECKER, B TERNON, A. OBENAUS (2010) Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference. (llu.edu)
Kidney1
- Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress. (vanderbilt.edu)
Patients3
- Patients in the rituximab group were treated with 100 mg on day 1, followed by 500 mg on day 2, continuing at that dose every 6 months. (neurologylive.com)
- 4-6 Patients with NMO have a life-long exposure to the uncontrolled complement activation due to chronic autoimmune attack, and most patients experience an unpredictable, relapsing course of disease with cumulative disability, as each attack adds to the neurologic disability. (aol.com)
- The single nucleotide polymorphism site of aquaporin-4 gene in patients with neuromyelitis optica. (cdc.gov)
Transmembrane3
- 10. Bienert GP, Chaumont F (2014) Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide. (sciendo.com)
- 11. Bienert GP, Heinen RB, Berny MC, Chaumont F (2014) Maize plasma membrane aquaporin ZmPIP2;5, but not ZmPIP1;2, facilitates transmembrane diffusion of hydrogen peroxide. (sciendo.com)
- Aquaporin-4 (Aqp4) is a passive transmembrane water channel that in the central nervous system (CNS) is exclusively expressed by astrocytes, and is an important molecular contributor to cerebral edema formation after cerebral ischemia [ 27 - 31 ]. (biomedcentral.com)
ELISA1
- The amount of synthesized colored products are positively related to the analyte of interest in the sample.This human IL-6 ELISA kit has been described in up to 143 publications. (cusabio.com)
Multiple sclerosis1
- The main questions it aims to answer are: Does the time to corticosteroid treatment affect the visual outcome at 6 months in subjects with acute multiple sclerosis (MS)-, aquaporin 4-IgG positive (AQP4-IgG+) and myelin-oligodendrocyte-glycoprotein-IgG positive (MOG-IgG+) ON? (medifind.com)
Diseases5
- Agre, P. & Kozono, D. Aquaporin water channels: molecular mechanisms for human diseases. (nature.com)
- Morishita, Y., Sakube, Y., Sasaki, S. & Ishibashi, K. Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporin superfamily (superaquaporins): expansion of aquaporins restricted to multicellular organisms. (nature.com)
- Dysregulated IL-6 has been associated with the pathogenesis of autoimmune and inflammatory diseases, metabolic abnormalities, and cancer. (cusabio.com)
- Targeting IL-6 has shown to be potential for the treatment of various immune-mediated diseases. (cusabio.com)
- In recent decades, there is an increasing interest in research on functional foods and dietary supplements for different diseases [ 3 - 6 ]. (primal-state.de)
Mutations3
- A few mutations result in the production of functional aquaporin 2 water channels, but these channels are misrouted within the cell and do not reach the cell membrane. (medlineplus.gov)
- Mutations in the gene encoding the vasopressin type-2 receptor cause the X-chromosomal form of the disease, whereas mutations in the gene encoding the vasopressin-dependent water channel aquaporin-2 are responsible for the autosomal recessive, and (in some cases) an autosomal dominant type of the disease. (rug.nl)
- In mice, mutations in the aquaporin-0 gene lead to congenital cataracts. (reviewofoptometry.com)
Mechanisms1
- 6. Cellular detoxification mechanisms of arsenic compounds. (sciendo.com)
Physiology4
- More than 200 members of the aquaporin family have been found in plants, microbials, invertebrates and vertebrates, and their importance to the physiology of these organisms is being uncovered. (elsevier.com)
- Experimental physiology , 88 (6), 691-698. (elsevier.com)
- American Journal of Physiology: Cell Physiology , 321 (6), 1060-1069. (au.dk)
- Previous studies performed in the Plant Development Physiology Laboratory showed a high preference for urea by the tank-bromeliad Vriesea gigantea and its possible transport via aquaporins. (fapesp.br)
Amino acid seq1
- An amino acid sequence from the C-terminus of human Aquaporin 6 (EPLKKESQPGSGAVEMESV) was used as the immunogen for this Aquaporin 6 antibody. (nsjbio.com)
Urea1
- 15/23210-6 - Analysis of urea assimilation in Vriesea gigantea (Bromeliaceae) plants with low urease activity: is mandatory the urea hydrolysis for its assimilation? (fapesp.br)
YEAST1
- Crystal structure of a yeast aquaporin at 1.15 angstrom reveals a novel gating mechanism. (mpg.de)
Renal water1
- Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. (medlineplus.gov)
Acinar cells1
- Serous-acinar cells express the tight junction marker zona occludens-1 and measurements of transepithelial electrical resistance (TEER) demonstrate exceptional tight junction formation [routinely >2000 omega(ohms)/cm2] in a relatively short period of time (6-8 days) in Transwell inserts. (cdc.gov)
Phosphorylation1
- Water transport activity of the plasma membrane aquaporin PM28A is regulated by phosphorylation. (nature.com)
Metabolism1
- In addition to regulating immune and inflammatory reactions, IL-6 also plays an important role in hematopoiesis, metabolism, and organ development. (cusabio.com)
Secretion1
- To assess the potential of this system as a model of reactive gliosis, astrocytes in 3D were activated with TGFbeta1 to a ramified, reactive phenotype (elevated GFAP, Aquaporin 4, CSPG, Vimentin and IL-6 secretion). (open.ac.uk)
Cells4
- This hormone triggers chemical reactions that ultimately insert aquaporin 2 water channels into the membrane of collecting duct cells. (medlineplus.gov)
- Without signals from ADH, aquaporin 2 water channels are removed from the membrane of collecting duct cells. (medlineplus.gov)
- If aquaporin 2 water channels are not inserted into the membrane of collecting duct cells, the kidneys are unable to respond to signals from ADH. (medlineplus.gov)
- prior 6-8 cells of stimulation promotes associated responsiveness which involves N-glycosylated to negatively 300 Needs of andwith per methylase. (evakoch.com)
Interleukin1
- The interleukin-6 receptor inhibitor satralizumab and anti-CD19 antibody inebilizumab have published positive phase III trial results and await approval in the near future. (mdc-berlin.de)