Aquaporin 1
Aquaporin 5
Aquaporin 5 is a water-specific channel protein that is expressed primarily in alveolar, tracheal, and upper bronchial EPITHELIUM. It plays an important role in maintaining water HOMEOSTASIS in the LUNGS and may also regulate release of SALIVA and TEARS in the SALIVARY GLANDS and the LACRIMAL GLAND.
Aquaporin 3
Aquaporin 4
Aquaporins
Aquaporin 2
Aquaporin 6
Water
Mercuric Chloride
Osmosis
Aquaglyceroporins
Blood Group Antigens
Water-Electrolyte Balance
Glycerol
Permeability
Cell Membrane Permeability
Plant Transpiration
Kidney Tubules, Collecting
Kidney Concentrating Ability
Diabetes Insipidus, Nephrogenic
A genetic or acquired polyuric disorder characterized by persistent hypotonic urine and HYPOKALEMIA. This condition is due to renal tubular insensitivity to VASOPRESSIN and failure to reduce urine volume. It may be the result of mutations of genes encoding VASOPRESSIN RECEPTORS or AQUAPORIN-2; KIDNEY DISEASES; adverse drug effects; or complications from PREGNANCY.
Plant Proteins
Ion Channels
Neuromyelitis Optica
Polyuria
Biological Transport
Xenopus laevis
Osmotic Pressure
Oocytes
Antidiuretic Agents
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Tulipa
Vapor Pressure
Amino Acid Sequence
Cistaceae
Plant Roots
Brain Edema
Increased intracellular or extracellular fluid in brain tissue. Cytotoxic brain edema (swelling due to increased intracellular fluid) is indicative of a disturbance in cell metabolism, and is commonly associated with hypoxic or ischemic injuries (see HYPOXIA, BRAIN). An increase in extracellular fluid may be caused by increased brain capillary permeability (vasogenic edema), an osmotic gradient, local blockages in interstitial fluid pathways, or by obstruction of CSF flow (e.g., obstructive HYDROCEPHALUS). (From Childs Nerv Syst 1992 Sep; 8(6):301-6)
Cell Membrane
Membrane Proteins
Lens, Crystalline
Gene Expression Regulation, Plant
Renal Agents
Drugs used for their effects on the kidneys' regulation of body fluid composition and volume. The most commonly used are the diuretics. Also included are drugs used for their antidiuretic and uricosuric actions, for their effects on the kidneys' clearance of other drugs, and for diagnosis of renal function.
Osmolar Concentration
Vasopressins
Antidiuretic hormones released by the NEUROHYPOPHYSIS of all vertebrates (structure varies with species) to regulate water balance and OSMOLARITY. In general, vasopressin is a nonapeptide consisting of a six-amino-acid ring with a cysteine 1 to cysteine 6 disulfide bridge or an octapeptide containing a CYSTINE. All mammals have arginine vasopressin except the pig with a lysine at position 8. Vasopressin, a vasoconstrictor, acts on the KIDNEY COLLECTING DUCTS to increase water reabsorption, increase blood volume and blood pressure.
Immunohistochemistry
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Glomeromycota
Microscopy, Electron, Scanning Transmission
A type of TRANSMISSION ELECTRON MICROSCOPY in which the object is examined directly by an extremely narrow electron beam scanning the specimen point-by-point and using the reactions of the electrons that are transmitted through the specimen to create the image. It should not be confused with SCANNING ELECTRON MICROSCOPY.
Salivary Glands
Deamino Arginine Vasopressin
Propylene Glycol
Mesophyll Cells
Mesembryanthemum
Kidney Medulla
Kidney
Acholeplasmataceae
Receptors, Vasopressin
Specific molecular sites or proteins on or in cells to which VASOPRESSINS bind or interact in order to modify the function of the cells. Two types of vasopressin receptor exist, the V1 receptor in the vascular smooth muscle and the V2 receptor in the kidneys. The V1 receptor can be subdivided into V1a and V1b (formerly V3) receptors.
Droughts
Astrocytes
A class of large neuroglial (macroglial) cells in the central nervous system - the largest and most numerous neuroglial cells in the brain and spinal cord. Astrocytes (from "star" cells) are irregularly shaped with many long processes, including those with "end feet" which form the glial (limiting) membrane and directly and indirectly contribute to the BLOOD-BRAIN BARRIER. They regulate the extracellular ionic and chemical environment, and "reactive astrocytes" (along with MICROGLIA) respond to injury.
Reverse Transcriptase Polymerase Chain Reaction
Xenopus
Mercury
A silver metallic element that exists as a liquid at room temperature. It has the atomic symbol Hg (from hydrargyrum, liquid silver), atomic number 80, and atomic weight 200.59. Mercury is used in many industrial applications and its salts have been employed therapeutically as purgatives, antisyphilitics, disinfectants, and astringents. It can be absorbed through the skin and mucous membranes which leads to MERCURY POISONING. Because of its toxicity, the clinical use of mercury and mercurials is diminishing.
Gene Expression
Rats, Sprague-Dawley
Spinacia oleracea
Glycerol Kinase
An enzyme that catalyzes the formation of glycerol 3-phosphate from ATP and glycerol. Dihydroxyacetone and L-glyceraldehyde can also act as acceptors; UTP and, in the case of the yeast enzyme, ITP and GTP can act as donors. It provides a way for glycerol derived from fats or glycerides to enter the glycolytic pathway. EC 2.7.1.30.
Protein Transport
Pichia
Rats, Brattleboro
Plant Stomata
Proteolipids
Protein-lipid combinations abundant in brain tissue, but also present in a wide variety of animal and plant tissues. In contrast to lipoproteins, they are insoluble in water, but soluble in a chloroform-methanol mixture. The protein moiety has a high content of hydrophobic amino acids. The associated lipids consist of a mixture of GLYCEROPHOSPHATES; CEREBROSIDES; and SULFOGLYCOSPHINGOLIPIDS; while lipoproteins contain PHOSPHOLIPIDS; CHOLESTEROL; and TRIGLYCERIDES.
Blotting, Western
Saline Solution, Hypertonic
Antimony Potassium Tartrate
Plant Leaves
Base Sequence
Malpighian Tubules
Glial Fibrillary Acidic Protein
Sequence Homology, Amino Acid
RNA, Complementary
Immunoblotting
Microscopy, Immunoelectron
Models, Molecular
Solute Carrier Family 12, Member 1
4-Chloromercuribenzenesulfonate
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
DNA Primers
Urea
Hypertonic Solutions
Arabidopsis
Gene Expression Regulation
Morula
Sodium-Potassium-Chloride Symporters
DNA, Complementary
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Quercus
Cloning, Molecular
Protein Conformation
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Zea mays
Molecular Dynamics Simulation
Hydroxyethyl Starch Derivatives
The cystic fibrosis transmembrane conductance regulator activates aquaporin 3 in airway epithelial cells. (1/184)
Enhanced osmotic water permeability has been observed in Xenopus oocytes expressing cystic fibrosis transmembrane conductance regulator (CFTR) protein. Subsequent studies have shown that CFTR activates an endogenous water permeability in oocytes, but that CFTR itself is not the water channel. Here, we show CFTR-dependent activation of endogenous water permeability in normal but not in cystic fibrosis human airway epithelial cells. Cell volume was measured by novel confocal x-z laser scanning microscopy. Glycerol uptake and antisense studies suggest CFTR-dependent regulation of aquaporin 3 (AQP3) water channels in airway epithelial cells. Regulatory interaction was confirmed by coexpression of CFTR and AQP3 cloned from human airways in Xenopus oocytes and of CFTR and rat AQP3 in Chinese hamster ovary cells. These findings indicate that CFTR is a regulator of AQP3 in airway epithelial cells. (+info)Transport of water and glycerol in aquaporin 3 is gated by H(+). (2/184)
Aquaporins (AQPs) were expressed in Xenopus laevis oocytes in order to study the effects of external pH and solute structure on permeabilities. For AQP3 the osmotic water permeability, L(p), was abolished at acid pH values with a pK of 6.4 and a Hill coefficient of 3. The L(p) values of AQP0, AQP1, AQP2, AQP4, and AQP5 were independent of pH. For AQP3 the glycerol permeability P(Gl), obtained from [(14)C]glycerol uptake, was abolished at acid pH values with a pK of 6.1 and a Hill coefficient of 6. Consequently, AQP3 acts as a glycerol and water channel at physiological pH, but predominantly as a glycerol channel at pH values around 6.1. The pH effects were reversible. The interactions between fluxes of water and straight chain polyols were inferred from reflection coefficients (sigma). For AQP3, water and glycerol interacted by competing for titratable site(s): sigma(Gl) was 0.15 at neutral pH but doubled at pH 6.4. The sigma values were smaller for polyols in which the -OH groups were free to form hydrogen bonds. The activation energy for the transport processes was around 5 kcal mol(-1). We suggest that water and polyols permeate AQP3 by forming successive hydrogen bonds with titratable sites. (+info)Renal expression of aquaporins in liver cirrhosis induced by chronic common bile duct ligation in rats. (3/184)
Semiquantitative immunoblotting was used to investigate the expression levels of the four major renal aquaporins, the Na-K-2Cl cotransporter of the thick ascending limb, the type 3 Na-H exchanger, and the Na-K-ATPase in kidneys from rats with cirrhosis secondary to common bile duct ligation (CBDL). These rats had significant water retention and hyponatremia. In contrast to models of cirrhosis induced by carbon tetrachloride, aquaporin-2 expression in CBDL-induced cirrhosis was decreased. Thus, these results show that in the setting of extracellular fluid volume expansion, excessive water retention with hyponatremia can occur in the absence of increases in aquaporin-2 abundance. In addition, the expression levels of the two basolateral collecting duct aquaporins (aquaporin-3 and -4) were decreased in CBDL rats relative to sham-operated control rats. Similarly, the Na-K-2Cl cotransporter of the thick ascending limb and the type 3 Na-H exchanger showed decreases in expression. In contrast, the expression levels of aquaporin-1 and the all subunit of the Na-K-ATPase were not decreased. Thus, dysregulation of multiple water channels and ion transporters may play a role in water balance abnormalities associated with CBDL-induced cirrhosis in rats. (+info)Functional characterization and localization of AQP3 in the human colon. (4/184)
Water channels or aquaporins (AQPs) have been identified in a large variety of tissues. Nevertheless, their role in the human gastrointestinal tract, where their action is essential for the reabsorption and secretion of water and electrolytes, is still unclear. The purpose of the present study was to investigate the structure and function of water channels expressed in the human colon. A cDNA fragment of about 420 bp with a 98% identity to human AQP3 was amplified from human stomach, small intestine and colon by reverse transcription polymerase chain reaction (RT-PCR) and a transcript of 2.2 kb was expressed more abundantly in colon than in jejunum, ileum and stomach as indicated by Northern blots. Expression of mRNA from the colon of adults and children but not from other gastrointestinal regions in Xenopus oocytes enhanced the osmotic water permeability, and the urea and glycerol transport in a manner sensitive to an antisense AQP3 oligonucleotide, indicating the presence of functional AQP3. Immunocytochemistry and immunofluorescence studies in human colon revealed that the AQP3 protein is restricted to the villus epithelial cells. The immunostaining within these cells was more intense in the apical than in the basolateral membranes. The presence of AQP3 in villus epithelial cells suggests that AQP3 is implicated in water absorption across human colonic surface cells. (+info)The role of aquaporins in dendritic cell macropinocytosis. (5/184)
Immature dendritic cells (DCs) constitutively take up large volumes of fluid by macropinocytosis and concentrate the macrosolutes in the endocytic compartment. This concentration mechanism that is the basis of their high capacity to present soluble antigens requires that DCs be capable of rapidly exchanging water across their membranes. We report that two members of the aquaporin family, AQP3 and AQP7, are expressed in immature DCs and are downregulated after maturation. Treatment of DCs with p-chloromercuribenzenesulphonate (pCMBS), a mercuric drug that blocks aquaporins, inhibited uptake and concentration of macrosolutes taken up by fluid phase endocytosis and led to dramatic cell swelling. In contrast, pCMBS did not affect receptor-mediated endocytosis via the mannose receptor. These findings indicate that aquaporins represent essential elements of a volume control mechanism that allows DCs to concentrate macrosolutes taken up via macropinocytosis. (+info)Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. (6/184)
Aquaporin-3 (AQP3) is a water channel expressed at the basolateral plasma membrane of kidney collecting-duct epithelial cells. The mouse AQP3 cDNA was isolated and encodes a 292-amino acid water/glycerol-transporting glycoprotein expressed in kidney, large airways, eye, urinary bladder, skin, and gastrointestinal tract. The mouse AQP3 gene was analyzed, and AQP3 null mice were generated by targeted gene disruption. The growth and phenotype of AQP3 null mice were grossly normal except for polyuria. AQP3 deletion had little effect on AQP1 or AQP4 protein expression but decreased AQP2 protein expression particularly in renal cortex. Fluid consumption in AQP3 null mice was more than 10-fold greater than that in wild-type litter mates, and urine osmolality (<275 milliosmol) was much lower than in wild-type mice (>1,200 milliosmol). After 1-desamino-8-d-arginine-vasopressin administration or water deprivation, the AQP3 null mice were able to concentrate their urine partially to approximately 30% of that in wild-type mice. Osmotic water permeability of cortical collecting-duct basolateral membrane, measured by a spatial filtering optics method, was >3-fold reduced by AQP3 deletion. To test the hypothesis that the residual concentrating ability of AQP3 null mice was due to the inner medullary collecting-duct water channel AQP4, AQP3/AQP4 double-knockout mice were generated. The double-knockout mice had greater impairment of urinary-concentrating ability than did the AQP3 single-knockout mice. Our findings establish a form of nephrogenic diabetes insipidus produced by impaired water permeability in collecting-duct basolateral membrane. Basolateral membrane aquaporins may thus provide blood-accessible targets for drug discovery of aquaretic inhibitors. (+info)Aquaporin 3 cloned from Xenopus laevis is regulated by the cystic fibrosis transmembrane conductance regulator. (7/184)
The cystic fibrosis transmembrane conductance regulator (CFTR) is essential for epithelial electrolyte transport and has been shown to be a regulator of epithelial Na(+), K(+), and Cl(-) channels. CFTR also enhances osmotic water permeability when activated by cAMP. This was detected initially in Xenopus oocytes and is also present in human airway epithelial cells, however, the mechanisms remain obscure. Here, we show that CFTR activates aquaporin 3 expressed endogenously and exogenously in oocytes of Xenopus laevis. The interaction requires stimulation of wild type CFTR by cAMP and an intact first nucleotide binding domain as demonstrated for other CFTR-protein interactions. (+info)Dysregulation of renal aquaporins and Na-Cl cotransporter in CCl4-induced cirrhosis. (8/184)
BACKGROUND: Severe hepatic cirrhosis is associated with abnormal renal water retention. METHODS: Semiquantitative immunoblotting was employed to investigate the abundance of the major renal aquaporins (water channels) and sodium-dependent cotransporters in kidneys from control rats and rats with cirrhosis secondary to chronic CCl4 inhalation. RESULTS: The cirrhotic rats had ascites and manifested a water excretion defect detected by a standard water-loading test. The abundance of aquaporin-1 (the major aquaporin in the proximal tubule) was increased, an effect markedly accentuated in high-density membrane fractions prepared by differential centrifugation. Differential centrifugation studies demonstrated a redistribution of aquaporin-2 from high-density to low-density membranes, compatible with increased trafficking of aquaporin-2 to the plasma membrane. The abundance of aquaporin-3, but not aquaporin-2, was increased in collecting ducts of rats with CCl4-induced cirrhosis. The Na-K-2Cl cotransporter of the thick ascending limb showed no change in abundance. However, the abundance of the thiazide-sensitive Na-Cl cotransporter of the distal convoluted tubule was markedly suppressed in cirrhotic rats, possibly contributing to a defect in urinary dilution. CONCLUSIONS: In this model of cirrhosis, the development of a defect in urinary dilution may be multifactorial, with contributions from at least four abnormalities in transporter regulation: (1) an increase in the renal abundance of aquaporin-1, (2) a cellular redistribution of aquaporin-2 in the collecting duct compatible with trafficking to the plasma membrane without an increase in total cellular aquaporin-2, (3) an increase in the renal abundance of aquaporin-3, and (4) a decrease in the abundance of the thiazide-sensitive cotransporter of the distal convoluted tubule. (+info)
Decreased lipases and fatty acid and glycerol transporter could explain reduced fat in diabetic morbidly obese<...
IJMS | Free Full-Text | Lipopolysaccharide Modifies Glycerol Permeability and Metabolism in 3T3-L1 Adipocytes
Molecular Exchange through the Vesicle Membrane of Siloxane Surfactant in Water/Glycerol Mixed Solvents
AQP10 Polyclonal Antibody, Biotin Conjugated | EpiGentek
GFIT result for T02297
Aquaporin 2 - Wikipedia
Anti -Aquaporin 4 Rabbit PAb for Rat IHC IF Primary Antibody from China manufacturer - Servicebio
Gentaur Molecular :FabGennix \ Aquaporin 4, FITC conjugates \ AQP4-FITC
Gentaur Molecular :FabGennix \ Aquaporin 8, Host species: Rabbit, Polyclonal antibody \ AQP-801AP
Aquaporin 4 - wikidoc
Aquaporin water channels - From atomic structure to clinical medicine<...
Expression and subcellular localization of aquaporin water channels in the polarized hepatocyte cell line, WIF-B<...
Comparative Molecular Physiology Unravelling the Complex Duplication History of Deuterostome Glycerol Transporters - IBB
Aquaporin water channels in liver: their significance in bile formation. | Semantic Scholar
Search
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Identification of key residues involved in Si transport by the aquaglyceroporins | Journal of General Physiology | Rockefeller...
Publications
An in-depth insight of a highly reversible and dendrite-free Zn metal by Yuanjun Zhang, Ming Zhu et al.
Aquaporin 1
Summary Report | CureHunter
Aquaporin A/S Profile
Aquaporin-8
Plasma Membrane Abundance of Human Aquaporin 5 Is Dynamically Regulated by Multiple Pathways - pdf descargar
Visualizing gene expression with MRI
RNAiDB Tree View
Portal - Browse - Keyword - A | aquaporin
Publications | Max Planck Institute for Biophysical Chemistry
Aquaporin water channels in liver: Their significance in bile formation - Marinelli - 2003 - Hepatology - Wiley Online Library
Conditional osmotic stress in yeast: a system to study transport through aquaglyceroporins and osmostress signaling<...
Role of Aquaporin 0 in lens biomechanics<...
Structure of a Nobel-prize winning molecule: Aquaporin
Molecular Basis of pH and Ca2+ Regulation of Aquaporin Water Permeability | Journal of General Physiology | Rockefeller...
Aquaporin 11/12 (IPR016697) | InterPro | EMBL-EBI
OriGene - Aqp4 (BC024526) cDNA Clone
AQP5 - Wikipedia
Aquaporin | Desalination
Aquaporin1 - What does Aquaporin1 stand for? The Free Dictionary
Estrogen prevents increased hepatic aquaporin-9 expression and glycerol uptake during starvation. | IRIS Univ. Bari
Aquaporin membrane protein, molecular model - Stock Image C035/5236 - Science Photo Library
Aquaporin 11, a regulator of water efflux at retinal Müller glial cell surface decreases concomitant with immune-mediated...
Blar i Department of Biological Sciences på tidsskrift Cells
ALZFORUM | NETWORKING FOR A CURE
Human GPX4(Glutathione Peroxidase 4) ELISA Kit - Aquaporin and water channels
Human PL(Placental Lactogen) ELISA Kit - Aquaporin and water channels
Anti-Aquaporin 3 Antibody
anti-Aquaporin 10 antibody, C-term | GeneTex
Aquaporin expression and function in human pluripotent stem cell -derived retinal pigment epithelial cells | IOVS | ARVO...
The Plasma Membrane of Arabidopsis thaliana Contains a Mercury-Insensitive Aquaporin That Is a Homolog of the Tonoplast Water...
Aquaporin-3 facilitates epidermal cell migration and proliferation during wound healing<...
Molecular Basis of pH and Ca2+ Regulation of Aquaporin Water Permeability | JGP
Evidence for the Expression of Aquaporin 5 in the Mammalian Conjunctival Epithelium | IOVS | ARVO Journals
Aquaporin-3 in Keratinocytes and Skin: Its Role and Interaction With Phospholipase D2
Nadia Skauli
- Institutt for medisinske basalfag
DataCite Search
Are aquaporin 4 antibodies appear in any other context than Devics syndrom?
Are aquaporin 4 antibodies appear in any other context than Devics syndrom?
The Gonen Lab: Structure Gallery
文章详细信息
Primary effusion lymphoma
Marlar S, Jensen HH, Login FH, Nejsum LN (October 2017). "Aquaporin-3 in Cancer". International Journal of Molecular Sciences. ... aquaporin 3, is a water channel that when overexpressed is thought to promote the progression and spread of various types of ... 73 (3): 792-9. doi:10.1182/blood.V73.3.792.bloodjournal733792. PMID 2537119. Cesarman E, Chang Y, Moore PS, Said JW, Knowles DM ... It has carried a median survival time of ~5 months, with overall survival rates at 1, 3, and 5 year of only 30, 18, and 17%, ...
GLUT1
... and aquaporin-1 in human erythrocyte membrane domains". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1828 (3): 956-66. ... 34 (2-3): 121-38. doi:10.1016/j.mam.2012.07.001. PMC 4104978. PMID 23506862. Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, ... 16 (3): 224-31. doi:10.1002/1098-1004(200009)16:3. 3.0.CO;2-P. PMID 10980529. S2CID 3169748. Online Mendelian Inheritance in ... 18 (3): 183-93. doi:10.1080/09687680110072140. PMID 11681785. S2CID 218897534. Baumann MU, Deborde S, Illsley NP (October 2002 ...
PLD2
Zheng X, Bollinger Bollag W (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane ... 467 (2-3): 326-32. doi:10.1016/s0014-5793(00)01174-1. PMID 10675563. S2CID 21891748. Kim JH, Lee S, Park JB, Lee SD, Kim JH, Ha ... N-(2-(1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide: 75-fold selective versus PLD1, IC50 = 20 ... 467 (2-3): 326-32. doi:10.1016/S0014-5793(00)01174-1. PMID 10675563. S2CID 21891748. Lee C, Kim SR, Chung JK, Frohman MA, ...
Caveolin 1
Zheng X, Bollinger Bollag W (December 2003). "Aquaporin 3 colocates with phospholipase d2 in caveolin-rich membrane ... 467 (2-3): 326-32. doi:10.1016/S0014-5793(00)01174-1. PMID 10675563. S2CID 21891748. Vargas L, Nore BF, Berglof A, Heinonen JE ... 56 (3): 355-6. doi:10.1006/geno.1998.5723. PMID 10087206. "Entrez Gene: CAV1 caveolin 1, caveolae protein, 22kDa". Li S, ...
Wernicke encephalopathy
... and the Aquaporin 4 channel. Focal lactic acidosis also causes secondary oedema, oxidative stress, inflammation and white ... 17 (3): 348-355. doi:10.1111/j.1468-1331.2009.02917.x. PMID 20050893. Kondo K, Fujiwara M, Murase M, Kodera Y, Akiyama S, Ito K ... 55 (1-3): 129-135. doi:10.1016/j.neuint.2009.02.020. PMID 19428817. S2CID 12615886. Hazell AS, Todd KG, Butterworth RF (June ... 42 (3): 226-231. doi:10.1136/jnnp.42.3.226. PMC 490724. PMID 438830. Blansjaar BA, Van Dijk JG (July 1992). "Korsakoff minus ...
Glymphatic system
Two types of aquaporins are expressed in the CNS: aquaporin-1, which is expressed by specialized epithelial cells of the ... Aquaporins are membrane-bound channels that play critical roles in regulating the flux of water into and out of cells. Relative ... Aquaporin-4 expression in astrocytes is highly polarized to the endfoot processes ensheathing the cerebral vasculature. Up to ... Verkman AS, Binder DK, Bloch O, Auguste K, Papadopoulos MC (August 2006). "Three distinct roles of aquaporin-4 in brain ...
Major intrinsic proteins
The MIP superfamily includes three subfamilies: aquaporins, aquaglyceroporins and S-aquaporins. The aquaporins (AQPs) are water ... Aquaporin-1 (Aqp1) from the human red blood cell has been solved by electron crystallography to 3.8 Å resolution (PDB: 1FQY). ... Aquaporins generally have the NPA motif in both halves, the glycerol facilitators generally have an NPA motif in the first ... Roles of aquaporins in human cancer have been reviewed as have their folding pathways. AQPs may act as transmembrane ...
Syndrome of inappropriate antidiuretic hormone secretion
... via activation of aquaporins, the site of the ADH receptors - back into the circulation. This has two consequences. First, in ... aquaporin 2), and their insertion into the cells' luminal membranes. Excessive ADH causes an inappropriate increase in the ... "Physiology and pathophysiology of renal aquaporins". Seminars in Nephrology. 21 (3): 231-8. doi:10.1053/snep.2001.21647. PMID ... ISBN 978-3-540-79565-0. Zietse, R.; van der Lubbe, N.; Hoorn, E. J. (2009). "Current and future treatment options in SIADH". ...
List of MeSH codes (D12.776.157)
... aquaporin 6 MeSH D12.776.157.530.400.500.040.374 - aquaporin 1 MeSH D12.776.157.530.400.500.040.437 - aquaporin 2 MeSH D12.776. ... 157.530.400.500.040.468 - aquaporin 4 MeSH D12.776.157.530.400.500.040.484 - aquaporin 5 MeSH D12.776.157.530.400.500.520 - ... aquaporins MeSH D12.776.157.530.400.500.040.249 - aquaglyceroporins MeSH D12.776.157.530.400.500.040.249.500 - aquaporin 3 MeSH ... glucose transporter type 3 MeSH D12.776.157.530.500.500.937 - glucose transporter type 4 MeSH D12.776.157.530.500.500.968 - ...
Tricho-hepato-enteric syndrome
... aquaporin 7, sodium iodide symporter and hydrogen potassium adenosine triphosphatase) showed reduced expression or ... 57 (3): 212-6. doi:10.1136/adc.57.3.212. PMC 1627586. PMID 7073301. Goulet O, Vinson C, Roquelaure B, Brousse N, Bodemer C, ... 3: 6. doi:10.1186/1750-1172-3-6. PMC 2279108. PMID 18304370. Verloes A, Lombet J, Lambert Y, et al. (February 1997). "Tricho- ... It has 43 exons of which exons 1, 2 and 3 are non coding. The predicted molecular weight of the protein is 175.486 kiloDaltons ...
Index of biophysics articles
Mershin Andrew Huxley Animal locomotion Animal locomotion on the water surface Anita Goel Antiporter Aquaporin 2 Aquaporin 3 ... Aquaporin 4 Archibald Hill Ariel Fernandez Arthropod exoskeleton Arthropod leg Avery Gilbert BEST2 BK channel Bacterial outer ... alpha 3 Cyclic nucleotide-gated channel alpha 4 Cyclic nucleotide-gated ion channel Cyclic nucleotide gated channel beta 3 Cys- ... Aggregate modulus Aharon Katzir Alan Lloyd Hodgkin Alexander Rich Alexander van Oudenaarden Allan McLeod Cormack Alpha-3 beta-4 ...
List of MeSH codes (D12.776.543)
... aquaporin 6 MeSH D12.776.543.550.425.730.040.374 - aquaporin 1 MeSH D12.776.543.550.425.730.040.437 - aquaporin 2 MeSH D12.776. ... aquaporin 6 MeSH D12.776.543.585.400.730.040.436 - aquaporin 1 MeSH D12.776.543.585.400.730.040.530 - aquaporin 2 MeSH D12.776. ... 543.550.425.730.040.468 - aquaporin 4 MeSH D12.776.543.550.425.730.040.484 - aquaporin 5 MeSH D12.776.543.550.425.730.520 - ... 543.585.400.730.040.577 - aquaporin 4 MeSH D12.776.543.585.400.730.040.600 - aquaporin 5 MeSH D12.776.543.585.400.730.520 - ...
Aquaporin
This results in aquaporin-2 containing vesicles to increase water uptake and return to circulation. Mutation of the aquaporin 2 ... The gating of an aquaporin is carried out by an interaction between a gating mechanism and the aquaporin, which causes a 3D ... It was not until 1992 that the first aquaporin, 'aquaporin-1' (originally known as CHIP 28), was reported by Peter Agre, of ... There have been two clear examples of diseases identified as resulting from mutations in aquaporins: Mutations in the aquaporin ...
Pulvinus
Aquaporins on the vacuole membrane of pulvini allow for the efflux of water that contributes to the change in turgor pressure. ... An upregulation[clarification needed] of water channel proteins (aquaporins) and membrane proteins which move solutes across a ... "Increased Expression of Vacuolar Aquaporin and H+-ATPase Related to Motor Cell Function in Mimosa pudica L". Plant Physiology. ... 114 (3): 827-834. doi:10.1104/pp.114.3.827. ISSN 0032-0889. PMC 158368. PMID 12223745. Volkov, Alexander G.; Foster, Justin C ...
Aquaporin-3
Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal ... 2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line". J. Membr. Biol. ... Aquaporin 3 is expressed more in atopic eczema. Recent studies indicate that aquaporin 3 is overexpressed in many types of ... Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including ...
Aquaporin-7
... and AQP3 are at the same chromosomal location suggesting that 9p13 may be a site of an aquaporin cluster. Aquaporin ... Aquaporin-7 (AQP-7) is a protein that in humans is encoded by the AQP7 gene. Aquaporins/major intrinsic proteins (MIP) are a ... "Entrez Gene: AQP7 aquaporin 7". Dibas AI, Mia AJ, Yorio T (1998). "Aquaporins (water channels): role in vasopressin-activated ... Aquaporin-7 has greater sequence similarity with AQP3 and AQP9 and they may be a subfamily. ...
Aquaporin-1
Aquaporin+1 at the US National Library of Medicine Medical Subject Headings (MeSH) Gallery of Aquaporin Simulations Human AQP1 ... "Entrez Gene: AQP1 aquaporin 1 (Colton blood group)". Knepper MA (July 1994). "The aquaporin family of molecular water channels ... The gene encoding this aquaporin is a possible candidate for disorders involving imbalance in ocular fluid movement. Aquaporin ... Aquaporin 1 (AQP-1) is a protein that in humans is encoded by the AQP1 gene. AQP-1 is a widely expressed water channel, whose ...
Aquaporin-6
... , (AQP-6) also known as kidney-specific aquaporin is a protein in humans that is encoded by the AQP6 gene. The ... Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). This protein ... "Entrez Gene: Aquaporin 6, kidney specific". Retrieved 2012-04-10. Human AQP6 genome location and AQP6 gene details page in the ... Ikeda M, Beitz E, Kozono D, Guggino WB, Agre P, Yasui M (Oct 2002). "Characterization of aquaporin-6 as a nitrate channel in ...
Aquaporin-5
... (AQP-5) is a protein that in humans is encoded by the AQP5 gene. Aquaporin-5 (AQP-5) is a water channel protein. ... Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin-5 ... "Entrez Gene: AQP5 aquaporin 5". Verkman AS (2003). "Role of aquaporin water channels in eye function". Exp. Eye Res. 76 (2): ... 2003). "Distribution of aquaporin water channels AQP1 and AQP5 in the ductal system of the human pancreas". Gut. 52 (7): 1008- ...
Aquaporin-4
The expression of aquaporin 4 is reliant on the disease stage of TBI. In an acute stage of TBI, the lack of aquaporin 4 causes ... Aquaporin-4, also known as AQP-4, is a water channel protein encoded by the AQP4 gene in humans. AQP-4 belongs to the aquaporin ... Aquaporin-4 is the most common aquaporin in the brain, spinal cord, and optic nerve. It is highly expressed in the human body ... Aquaporin-4 is essential in the formation of memory as well as synaptic plasticity. Other performances that aquaporin-4 is ...
Aquaporin-8
... is a protein that in humans is encoded by the AQP8 gene. Aquaporin-8 (AQP-8) is a water channel protein. Aquaporins ... "Entrez Gene: AQP8 aquaporin 8". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of ... 2007). "Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis". World J. ... Wang S, Chen J, Au KT, Ross MG (2003). "Expression of aquaporin 8 and its up-regulation by cyclic adenosine monophosphate in ...
Aquaporin-2
It is the only aquaporin regulated by vasopressin. The basic job of aquaporin 2 is to reabsorb water from the urine while its ... This aquaporin is also regulated by food intake. Fasting reduces expression of this aquaporin independently of vasopressin. ... so the aquaporin 2 can be used by the cell. This aquaporin is regulated in two ways by the peptide hormone vasopressin: short- ... Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular ...
Andreas Engel
Agre, P.; King, L. S.; Yasui, M.; Guggino, W. B.; Ottersen, O. P.; Fujiyoshi, Y.; Engel, A.; Nielsen, S. (2002). "Aquaporin ... Fujiyoshi and Engel solved the structure of Aquaporin-1 in collaboration with Agre. Together with Palczewski Engel's team ... 177 (1): 3-13. doi:10.1016/j.jsb.2011.11.013. PMID 22115996. "Farewell Symposium for Andreas Engel". unibas.ch. Archived from ... 542 (1): 3-16. doi:10.1113/jphysiol.2002.020818. PMC 2290382. PMID 12096044. "Structure of the rhodopsin dimer: a working model ...
Congenital cataract
... or Aquaporin, cytoskeletal structural proteins, paired-like homeodomain transcription factor 3 (PITX3), avian ... Any central opacity or surrounding cortical distortion greater than 3 mm can be assumed to be visually significant. Laboratory ...
Contractile vacuole
Water has been shown in at least some species to enter the CV through aquaporins. Acidocalcisomes have been implied to work ... Although it is known that several proteins decorate the CV membrane (V−H+−ATPases, aquaporins), a complete list is missing. The ... "Presence of aquaporin and V-ATPase on the contractile vacuole of Amoeba proteus". Biol Cell. 100 (3): 179-188. doi:10.1042/ ...
Neuromyelitis optica spectrum disorder
In 2005 they identified the aquaporin 4 protein as the target of the disease, and developed the first in-house test to aid in ... In more than 80% of cases, IgG autoantibodies against aquaporin-4 (anti-AQP4+) are the cause, and in 10-40% of the remaining ... In more than 80% of cases, NMO is caused by immunoglobulin G autoantibodies to aquaporin 4 (anti-AQP4), the most abundant water ... Some authors propose to use the name "autoimmune aquaporin-4 channelopathy" for these diseases, while others prefer a more ...
Lesional demyelinations of the central nervous system
Around active NMO lesions AQP4 may selectively be lost in the absence of aquaporin 1 (AQP1) loss or other structural damage ( ... 246 (3): 880-6. doi:10.1148/radiol.2463070486. PMID 18195384. Calabrese M, Filippi M, Rovaris M, Mattisi I, Bernardi V, Atzori ... 19 (3): 242-247. doi:10.1097/01.wco.0000227032.47458.cb. PMID 16702829. S2CID 2687650. De Groot CJ, Bergers E, Kamphorst W, ... 2 (3): 295-301. doi:10.1002/acn3.164. PMC 4369279. PMID 25815356. Young NP, Weinshenker BG, Parisi JE, Scheithauer B, Giannini ...
Ralf Kaldenhoff
Aquaporin tetramer composition modifies the function of tobacco aquaporins. Journal of Biological Chemistry, 2010. 285(41): p. ... He is known for his work on the aquaporin protein class, where he detected facilitated diffusion of CO2 in plant tissue and ... Kaldenhoff was one of the first scientists to describe plant aquaporins. He initially accomplished to analyse the function and ... For the first time, Kaldenhoff could provide evidence that an aquaporin molecule could conduct CO₂. Kaldenhoff also worked on ...
Vasopressin
Aquaporins allow water to move down their osmotic gradient and out of the nephron, increasing the amount of water re-absorbed ... Vasopressin, acting through cAMP, also increases transcription of the aquaporin-2 gene, thus increasing the total number of ... This occurs through increased transcription and insertion of water channels (Aquaporin-2) into the apical membrane of ... Wilson JL, Miranda CA, Knepper MA (2013). "Vasopressin and the Regulation of Aquaporin-2". Clinical and Experimental Nephrology ...
Calixarene
A tetrathia[4]arene is found to mimic some properties of the aquaporin proteins. This calixarene adopts a 1,3-alternate ... In calix[4]arene 4 up-down conformations exist: cone (point group C2v,C4v), partial cone Cs, 1,2 alternate C2h and 1,3 ... 13 (3): 295-299. doi:10.1590/S0103-50532002000300002. Jin, Jaehyeok; Park, Ji Young; Lee, Yoon Sup (2016-10-27). "Optical ... 65 (3): 387-392. doi:10.1351/pac199365030387. S2CID 97287177. Gu, Alice; Wheate, Nial (2021). "Macrocycles as drug-enhancing ...
TRPV
aquaporin 5, calmodulin, pacsin 3 2 TRPV5 calcium-selective TRP channel intestine, kidney, placenta 100:1 TRPV6 annexin II / ... 22 (3): 454-64. doi:10.1097/00006123-198803000-00002. PMID 3129667.. *^ Cosens DJ, Manning A (October 1969). "Abnormal ... Physiol. 129 (3): 191-207. doi:10.1085/jgp.200709731. PMC 2151614. PMID 17325193.. {{cite journal}}. : CS1 maint: multiple ... 3] that displayed transient elevation of potential in response to light stimuli, and were therefore named "transient receptor ...
Calmodulin
It does this by binding various targets in the cell including a large number of enzymes, ion channels, aquaporins and other ... 3 Role in animals *3.1 Specific examples *3.1.1 Role in smooth muscle contraction ...
Nephron
Aquaporins are membrane proteins that selectively conduct water molecules while preventing the passage of ions and other ... ADH affects the function of aquaporins, resulting in the reabsorption of water molecules as it passes through the collecting ... p. 3. ISBN 978-0-07-166339-7. "Regulation of Urine Concentration". Anatomy & Physiology. CliffsNotes. Archived from the ... doi:10.1038/s41581-018-0078-3. PMID 30455427. S2CID 53872296. (Articles with short description, Short description is different ...
Biometal (biology)
Potassium absorption has a positive correlation with aquaporins and the uptake of water in plant cells via cell membrane ... doi:10.1007/978-3-319-90143-5_1. ISBN 978-3-319-90143-5. PMID 29884959. S2CID 46997332. Banci L, ed. (2013). Metallomics and ... 14 (3): 513-543. doi:10.1016/S0300-595X(85)80005-0. PMID 3905079. Cavalieri RR (April 1997). "Iodine metabolism and thyroid ... 15 (3): 307-321. doi:10.1023/A:1016091118585. ISSN 1572-8773. PMID 12206396. S2CID 32535554. Cuajungco MP, Ramirez MS, Tolmasky ...
Syntrophin, alpha 1
... has been shown to interact with Dystrophin, Nav1.1 and Nav1.5, and Aquaporin 4. GRCh38: Ensembl release 89 ... "In vivo requirement of the alpha-syntrophin PDZ domain for the sarcolemmal localization of nNOS and aquaporin-4". J. Cell Biol ... "Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein". Proc. Natl. Acad. Sci. U.S.A. 98 (24): ... "Syntrophin-dependent expression and localization of Aquaporin-4 water channel protein". Proc. Natl. Acad. Sci. U.S.A. 98 (24): ...
Jane Osbourn
Shanahan, CM (1999). "Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across ... 1999 Aquaporin-1 is expressed by vascular smooth muscle cells and mediates rapid water transport across vascular cell membranes ... 14 (3): 309-314. doi:10.1038/nbt0396-309. PMID 9630891. S2CID 23088502. Vaughan, T. J.; Osbourn, J. K.; Tempest, P. R. (30 June ... Chodorge, M (3 December 2018). "Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes ...
Mir-708 microRNA precursor family
"Aquaporin-1 promotes angiogenesis, fibrosis, and portal hypertension through mechanisms dependent on osmotically sensitive ... 116 (3): 437-45. doi:10.1182/blood-2008-06-165985. PMID 20445018. Patnaik SK, Kannisto E, Knudsen S, Yendamuri S (January 2010 ...
Index of biochemistry articles
... aquaporin - archaea - arginine - argipressin - aromatic amine - aromatic compound - arrestin - Arrhenius equation - aryl ... 3' end - 5' end ABC-Transporter Genes - abl gene - acetic acid - acetyl CoA - acetylcholine - acetylcysteine - acid - acidic ... tyrosine 3-monooxygenase ubiquitin - urea - urea cycle - uric acid - UV/VIS spectroscopy vaccine - vacuole - valence - valine ... interleukin-3 receptor - intermediate filament - intermediate filament protein - intermembrane space - Intermolecular force - ...
Kangaroo rat
To help conserve water they produce very concentrated urine, via a process apparently associated with expression of aquaporin 1 ... 72 (3): 771-777. doi:10.2307/1940579. JSTOR 1940579. Randall, J. A. (January 1987). "Field Observations of Male Competition and ...
VAMP2
... possible role in aquaporin-2 trafficking". The Journal of Clinical Investigation. 98 (4): 906-13. doi:10.1172/JCI118873. PMC ... 33 (3): 397-409. doi:10.1016/s0896-6273(02)00583-4. PMID 11832227. S2CID 17878965. Paumet F, Le Mao J, Martin S, Galli T, David ... 317 (3): 945-54. doi:10.1042/bj3170945. PMC 1217577. PMID 8760387. Mandon B, Chou CL, Nielsen S, Knepper MA (Aug 1996). " ... 317 (3): 945-54. doi:10.1042/bj3170945. PMC 1217577. PMID 8760387. Reed GL, Houng AK, Fitzgerald ML (Apr 1999). "Human ...
Epithelial sodium channel
... aquaporins or Na/K-ATPase. In sweat glands, CFTR is responsible for the reabsorption of chloride in the sweat duct. Sodium ions ... 137 (3): 339-53. doi:10.1007/s00418-011-0904-1. PMID 22207244. S2CID 15178940. Sharma S, Hanukoglu A, Hanukoglu I (April 2018 ... 13 (3): 149-57. doi:10.3109/09687689609160591. PMID 8905643. Waldmann R, Champigny G, Bassilana F, Voilley N, Lazdunski M ( ... 21 (3-4): 83-96. doi:10.1159/000334611. PMC 3290041. PMID 22286036. Saxena A, Hanukoglu I, Strautnieks SS, Thompson RJ, ...
Neurohypophysial hormone
"Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2". Nephrol. Dial. Transplant. 19 ( ... 81 (3): 1197-267. doi:10.1152/physrev.2001.81.3.1197. PMID 11427695. Jones CW, Pickering BT (December 1972). "Intra-axonal ...
Myelin oligodendrocyte glycoprotein
The presence of anti-MOG autoantibodies has been associated with the following conditions Most cases of aquaporin-4- ... 2 (3): 295-301. doi:10.1002/acn3.164. PMC 4369279. PMID 25815356. Baumann M, Hennes EM, Schanda K, Karenfort M, Kornek B, Seidl ... 3] It is a transmembrane protein expressed on the surface of oligodendrocyte cell and on the outermost surface of myelin ... "14 Alu sequences within 3 introns", and have a range varying from 242 to 6484 bp. Alternatively spliced human mRNA of the MOG ...
SNAP23
... colocalization with aquaporin-2 in collecting duct vesicles". The American Journal of Physiology. 275 (5 Pt 2): F752-60. doi: ... 231 (3): 808-12. doi:10.1006/bbrc.1997.6196. PMID 9070898. Ravichandran V, Chawla A, Roche PA (Jun 1996). "Identification of a ... 108 (3): 211-5. doi:10.1007/s004390100480. PMID 11354632. S2CID 38554877. Shukla A, Corydon TJ, Nielsen S, Hoffmann HJ, Dahl R ... Riento K, Galli T, Jansson S, Ehnholm C, Lehtonen E, Olkkonen VM (Sep 1998). "Interaction of Munc-18-2 with syntaxin 3 controls ...
Inebilizumab
NMOSD can be associated with antibodies that bind to a protein called aquaporin-4 (AQP4). Binding of the anti-AQP4 antibody ... who are anti-aquaporin 4 immunoglobulin G (AQP4-IgG) seropositive. The applicant for this medicinal product is Viela Bio. ... patients who are anti-aquaporin-4 or AQP4 antibody positive). NMOSD is a rare autoimmune disorder in which immune system cells ... doi:10.1016/S0140-6736(19)31817-3. PMID 31495497. S2CID 201839513. "Inebilizumab". Drug Information Portal. U.S. National ...
Primary polydipsia
June 1999). "Urinary excretion of aquaporin-2 water channel differentiates psychogenic polydipsia from central diabetes ... 19 (3): 759-762. doi:10.1111/j.1530-0277.1995.tb01579.x. ISSN 0145-6008. PMID 7573805. Fichman, M. P.; Kleeman, C. R.; Bethune ... 73 Suppl 3: S4-12. doi:10.3949/ccjm.73.suppl_3.s4. ISSN 0891-1150. PMID 16970147. S2CID 20582060. Takagi, Shunsuke; Watanabe, ... 11 (3): 222-223. doi:10.1097/00004714-199106000-00022. ISSN 0271-0749. PMID 2066464. Kruse, D.; Pantelis, C.; Rudd, R.; Quek, J ...
List of autoimmune diseases
"IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel". Journal of Experimental Medicine. 202 (4 ... "Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression". Archives of Neurology. 63 (7): 964-968. ... 50 (3): 481-8. doi:10.1093/rheumatology/keq362. PMID 21097451. Hinks A, Martin P, Flynn E, Eyre S, Packham J, Barton A, ... 22 (3): 101-2, author reply 103. doi:10.1016/j.pt.2006.01.001. PMID 16446117. Agustí A, MacNee W, Donaldson K, Cosio M (2003 ...
Satralizumab
NMOSD can be associated with antibodies that bind to a protein called aquaporin-4 (AQP4). Binding of the anti-AQP4 antibody ... people who are anti-aquaporin-4 or AQP4 antibody-positive. NMOSD is a rare autoimmune disease of the central nervous system ... of 116 participants with NMOSD who were anti-aquaporin-4 (AQP4) antibody positive. The trials were conducted at 62 sites in the ... including the formation of pathological autoantibodies against aquaporin-4 (AQP4), and the permeability of the blood-brain ...
Mitochondrial matrix
... although the membrane contains aquaporins that are believed to be conduits for regulated water transport. Mitochondrial matrix ... ISBN 978-0-8153-3218-3. Anderson, S.; Bankier, A. T.; Barrell, B. G.; de Bruijn, M. H. L.; Coulson, A. R.; Drouin, J.; Eperon, ... 174 (3): 497-525. doi:10.1016/0022-2836(84)90333-4. PMID 6143829. Denton, Richard M.; Randle, Philip J.; Bridges, Barbara J.; ... 19 (3): 183-194. doi:10.1007/bf00986960. PMID 7969106. S2CID 21200502. (Articles with short description, Short description is ...
Aphid
"A water-specific aquaporin involved in aphid osmoregulation". Insect Biochemistry and Molecular Biology. 39 (1): 1-10. doi: ... 11 (3): 259-277. doi:10.1111/j.1095-8312.1979.tb00038.x. Gullan, P. J.; Cranston, P. S. (2010). The Insects: An Outline of ... doi:10.1007/978-3-319-28068-4_7. ISBN 9783319280660. Weldon, S. R.; Strand, M. R.; Oliver, K. M. (2013-01-22). "Phage loss and ... 92 (3): 125-131. doi:10.1016/j.jip.2006.03.009. PMID 16780867. Lady Beetle Releases for Aphid Control: How to Help Them Work ...
Arsenic biochemistry
... enters the cells though aquaporins 7 and 9, which is a type of aquaglyceroporin. Arsenic (V) compounds use phosphate ... ISBN 978-3-527-29390-2 Park, Woo H. Park; Jae G. Seol; Eun S. Kim; Jung M. Hyun; Chul W. Jung; Chung C. Lee; Byoung K. Kim; ... 228 (3): 385-394. doi:10.1016/j.taap.2007.12.019. PMID 18252256. Hunt, K. M; Srivastava, R. K; Elmets, C. A; Athar, M. (2014 ... 49 (3): 171-178. doi:10.1248/jhs.49.171. Retrieved 2011-01-10. Jun Zhu; Zhu Chen; Valérie Lallemand-Breitenbach; Hugues de Thé ...
Cerebrospinal fluid
This creates osmotic pressure and draws water into CSF, facilitated by aquaporins. Chloride, with a negative charge, moves with ... and specific antibodies such as aquaporin-4 may be tested for to assist in the diagnosis of autoimmune conditions. A lumbar ... Infants have a CSF volume of 4 mL/kg, children have a CSF volume of 3 mL/kg, and adults have a CSF volume of 1.5-2 mL/kg. A ... 67 (3): 209-13. PMID 18828104. Sharifi M, Ciołkowski M, Krajewski P, Ciszek B (August 2005). "The choroid plexus of the fourth ...
Bone marrow
Only mature blood cells contain the membrane proteins, such as aquaporin and glycophorin, that are required to attach to and ... 3 July 2013. Retrieved 3 July 2013. "HIV Returns in Two Men Thought 'Cured' by Bone Marrow Transplants". RH Reality Check. 10 ... 3 (4): 166-177. doi:10.1016/j.jot.2015.07.004. PMC 5986987. PMID 30035055. Nishida, Y; Matsue, Y; Suehara, Y; Fukumoto, K; ... 3/7. C., Farhi, Diane (2009). Pathology of bone marrow and blood cells (2nd ed.). Philadelphia: Wolters Kluwer Health/ ...
Neuritis
May 2007). "Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis". ... is characterized by neuromyelitis optica IgG antibodies which selectively bind to aquaporin-4. Optic neuritis is associated ... 175 (3): 336-48. doi:10.1111/cei.12185. PMC 3927895. PMID 23937626. Ang CD, Alviar MJ, Dans AL, Bautista-Velez GG, Villaruz- ... ISBN 978-3-319-93904-9. OCLC 1048610895. Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health ( ...
Aquaporin-3 - Wikipedia
Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. It is found in the basolateral cell membrane of principal ... 2005). "Roles of aquaporin-3 water channels in volume-regulatory water flow in a human epithelial cell line". J. Membr. Biol. ... Aquaporin 3 is expressed more in atopic eczema. Recent studies indicate that aquaporin 3 is overexpressed in many types of ... Aquaporin-3 is also permeable to glycerol, ammonia, urea, and hydrogen peroxide. It is expressed in various tissues including ...
Human Metabolome Database: HMDBP02583 (Aquaporin-3) Metabolite Associations
This project is supported by the Canadian Institutes of Health Research, Canada Foundation for Innovation, and by The Metabolomics Innovation Centre (TMIC), a nationally-funded research and core facility that supports a wide range of cutting-edge metabolomic studies. TMIC is funded by Genome Canada, Genome Alberta, and Genome British Columbia, a not-for-profit organization that is leading Canadas national genomics strategy with $900 million in funding from the federal government ...
LOINC LG50124-3 - Aquaporin 4 water channel Ab.IgG|PrThr|Pt|CSF
LOINC Code LG50124-3 Aquaporin 4 water channel Ab.IgG,PrThr,Pt,CSF ... Aquaporin 4 water channel IgG Ab [Presence] in Cerebral spinal fluid by Cell binding immunofluorescent assay. ... Aquaporin 4 water channel IgG Ab [Presence] in Cerebral spinal fluid Archetype. ... LG50124-3Aquaporin 4 water channel Ab.IgG,. PrThr,. Pt,. CSFActive. Basic Attributes. Version First Released. Pending promotion ...
Aquaporins in Melanocytic and Nonmelanocytic Skin Tumors
This study investigated the role of aquaporin 1 and aquaporin 3 in the pathobiology of skin cancers. Might they have potential ... Objectives: Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the ... Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors. ... Aquaporin (AQP) expression has been identified in various skin structures.[1] Specifically, AQP1 has been found in the ...
Blue Light Induces Down-Regulation of Aquaporin 1, 3, and 9 in Human Keratinocytes
Aquaporins (AQPs) are water membrane channels that permeate both water and glycerol and play an important role in the hydration ... Aquaporins (AQPs) are water membrane channels that permeate both water and glycerol and play an important role in the hydration ... Blue Light Induces Down-Regulation of Aquaporin 1, 3, and 9 in Human Keratinocytes. Avola, Rosanna;Graziano, Adriana Carol ... Si ricorda che il superamento dei valori soglia (almeno 2 su 3) è requisito necessario ma non sufficiente al conseguimento ...
Frontiers | Higher Expression Levels of Aquaporin Family of Proteins in the Kidneys of Arid-Desert Living Lepus yarkandensis
Aquaporins (AQPs) are a family of channel proteins that facilitate water transportation across cell membranes. Kidney AQPs play ... Aquaporins (AQPs) are a family of channel proteins that facilitate water transportation across cell membranes. Kidney AQPs play ... 2000). Nephrogenic diabetes insipidus in mice lacking aquaporin-3 water channels. Proc. Natl. Acad. Sci. U.S.A. 97, 4386-4391. ... 2001). Immunolocalization of aquaporin-8 in rat kidney, gastrointestinal tract, testis, and airways. Am. J. Physiol. Renal. ...
Gain-of-function mutations in Aqp3a influence zebrafish pigment pattern formation through the tissue environment
Here, we describe novel zebrafish mau mutants, which encompass several dominant missense mutations in Aquaporin 3a (Aqp3a) that ... 3 Max Planck Institute for Developmental Biology, 72076 Tübingen, Germany [email protected] ...
Vesicular Palmoplantar Eczema: Background, Pathophysiology, Etiology of Palmoplantar Eczema
The key role of aquaporin 3 and aquaporin 10 in the pathogensis of pompholyx. Med Hypotheses. 2015 05. 84(5):498-503. [QxMD ... One study examined the roles of aquaporin 3 and aquaporin 10, which are water/glycerol channel proteins located in the ... Guillet MH, Wierzbicka E, Guillet S, Dagregorio G, Guillet G. A 3-year causative study of pompholyx in 120 patients. Arch ...
Structural mechanism of plant aquaporin gating | Nature
Living cells regulate the movement of water via pores in the cell membrane called aquaporins. In a study of plant aquaporin, ... Here we report the X-ray structure of the spinach plasma membrane aquaporin SoPIP2;1 in its closed conformation at 2.1 Å ... These results reveal a molecular gating mechanism which appears conserved throughout all plant plasma membrane aquaporins. ... Plants counteract fluctuations in water supply by regulating all aquaporins in the cell plasma membrane. Channel closure ...
Vesicular Palmoplantar Eczema: Background, Pathophysiology, Etiology of Palmoplantar Eczema
The key role of aquaporin 3 and aquaporin 10 in the pathogensis of pompholyx. Med Hypotheses. 2015 05. 84(5):498-503. [QxMD ... One study examined the roles of aquaporin 3 and aquaporin 10, which are water/glycerol channel proteins located in the ... Guillet MH, Wierzbicka E, Guillet S, Dagregorio G, Guillet G. A 3-year causative study of pompholyx in 120 patients. Arch ...
Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3<...
Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. Journal of Biological Chemistry. 2002 ... Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. / Tonghui, Ma; Hara, Mariko; Sougrat, ... Dive into the research topics of Impaired stratum corneum hydration in mice lacking epidermal water channel aquaporin-3. ... The water/small solute-transporting protein aquaporin-3 (AQP3) was found by immunofluorescence and immunogold electron ...
AQP2 gene: MedlinePlus Genetics
The AQP2 gene provides instructions for making a protein called aquaporin 2. Learn about this gene and related health ... If aquaporin 2 water channels are not inserted into the membrane of collecting duct cells, the kidneys are unable to respond to ... The aquaporin 2 water channel plays an essential role in maintaining the bodys water balance. The placement of these channels ... Most of the known AQP2 gene mutations cause the aquaporin 2 protein to be misfolded into an incorrect 3-dimensional shape. The ...
Current Insights into Treating Vertigo in Older Adults | SpringerLink
Glucocorticoids stimulate endolymphatic water reabsorption in inner ear through aquaporin 3 regulation. Pflugers Arch. 2015;467 ... and by control of the aquaporin channels [77]. Finally, cochlear blood flow may be positively affected by topical application ... Table 3 Diuretics used in the treatment of MDs intercritical phase. Full size table. ... 3. In the case of acute vertigo, the use of vestibular suppressants should be limited only to the acute phase of the disease in ...
Dry Skin | GreenMedInfo | Disease | Natural Medicine | Alternative
Aquaporins
The Georges Morel 2018 prize was awarded to Christophe Maurel, deputy director of BPMP and head of the Aquaporin team. This ... 2017) Aquaporins facilitate hydrogen peroxide entry into guard cells to mediate ABA- and pathogen-triggered stomatal closure. ... 2019) Oscillating aquaporin phosphorylations and 14-3-3 proteins mediate the circadian regulation of leaf hydraulics. Plant ... 2016) Novel aquaporin regulatory mechanisms revealed by interactomics. Mol. Cell. Proteomics, 15(11):3473-3487 ...
Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection | Nature...
Our data also showed significant upregulation of Aquaporin 3 at 48 hpi in HepG2 cells and HC04 cells (Supplementary Data 4). ... Plasmodium parasite exploits host aquaporin-3 during liver stage malaria infection. PLOS Pathog. 14, e1007057 (2018). ... 3. Temporal detection of MUC13 in HC04 cells infected with P. berghei. a HC04 cells were infected with P. berghei sporozoites ... berghei and identified Aquaporin 3 as differentially expressed in HepG2 cells at 24 hpi45. ...
response to oxygen-glucose deprivation - Ontology Report - Rat Genome Database
aquaporin 3 (Gill blood group). acts_upstream_of_or_within. involved_in. ISO. IEA. (MGI:5551666,PMID:24462679). MGI. Ensembl. ... BCL2 interacting protein 3. ISO. RGD. PMID:22639046. RGD:14398458. NCBI chrNW_004936486:18,449,371...18,460,435 Ensembl chrNW_ ... calcium voltage-gated channel auxiliary subunit beta 3. ISO. RGD. PMID:23421680. RGD:13514095. NCBI chrNW_004936512:6,652,836 ...
IJMS | Free Full-Text | Skin Protective Effect of Epigallocatechin Gallate
3 in HaCaT cells. EGCG reduced melanin secretion and production in melanoma cells. Together, these results suggest that EGCG ... CPT-11-Induced Delayed Diarrhea Develops via Reduced Aquaporin-3 Expression in the Colon ... Figure 3. The antioxidative activities of EGCG. (a) EGCG (0-25 μM) was reacted with 2,2-diphenyl-1-picrylhydrazyl (DPPH) in the ... Figure 3. The antioxidative activities of EGCG. (a) EGCG (0-25 μM) was reacted with 2,2-diphenyl-1-picrylhydrazyl (DPPH) in the ...
Anti-ApoE3 Antibody | 26-5696-30T
Chang Lab
Miller, E. W.; Dickinson, B. C.; Chang, C. J. "Aquaporin-3 Mediates Hydrogen Peroxide Uptake to Regulate Downstream ... Sci. 2012, 3, 1829-1834. [pdf] [html] 93. Sundstrom, E. J.; Yang, X.; Thoi, V. S.; Karunadasa, H. I.; Chang, C. J.; Long, J. R ... Sci. 2017, 3, 1032-1040. [html] [pdf] 167. Burgos-Barragan, G.; Wit, N.; Meiser, J.; Dingler, F. A.; Pietzke, M.; Mulderrig, L ... Biol. 2007, 3, 263-267. [pdf] [C & E News]. 34. Miller, E. W.; Bian, S. X.; Chang, C. J. "A Fluorescent Sensor for Imaging ...
Lipid that helps keep skin cell turnover on track may aid in psoriasis
Aquaporin (AQP2, 12q13, APQ4, 18q11.2-q12.1) | SpringerLink
The aquaporin channel of plants is closed when two conserved serine residues are dephosphorylated or when a conserved histidine ... 2008). Aquaporin (AQP2, 12q13, APQ4, 18q11.2-q12.1). In: Encyclopedia of Genetics, Genomics, Proteomics and Informatics. ... cAMP-dependent mechanisms or PKA activate the aquaporin channel. It is important for various types of cells, diabetes, kidney ...
WikiGenes - Polyuria
Downregulation of aquaporin-2 and -3 in aging kidney is independent of V(2) vasopressin receptor. Preisser, L., Teillet, L., ... Decreased aquaporin-2 expression and apical plasma membrane delivery in kidney collecting ducts of polyuric hypercalcemic rats. ... Role of water channels in fluid transport studied by phenotype analysis of aquaporin knockout mice. Verkman, A.S., Yang, B., ... Hypokalemia-induced downregulation of aquaporin-2 water channel expression in rat kidney medulla and cortex. Marples, D., ...
JournalTOCs
KLF5-mediated aquaporin 3 activated autophagy to facilitate cisplatin. resistance of gastric cancer. Open Access Article* Free ... cortex injury is mediated by regulation of HO-1/PPAR-γ, SIRT1/FOXO-3,. JNK/AP-1, TLR4/iNOS, and Ang II/Ang 1-7 signals* Free ... N-antipyrine-3,4-dichloromaleimide derivatives is due to an. immunomodulatory effect on cytokines environment* Free pre-print ... Hybrid journal * Containing 3 Open Access article(s) in this issue *. ISSN (Print) 0892-3973 - ISSN (Online) 1532-2513. ...
AquaPorin Hydrating Cream - 1.7 oz - Circadia®
AquaPorin Hydrating Cream - 1.7 oz. Home \ Retail Products \ Retail Hydrating/Moisturizing \ AquaPorin Hydrating Cream - 1.7 oz ... AquaPorin Hydrating Cream - 1.7 oz. Log in to see prices. Hydrate with natural oils to maintain and increase skin moisture. ... Boosts Aquaporin-3 which promotes inner hydration mechanisms and water movement from the basal layer of epidermis and to the ... Increases Aquaporins-3, 9, and 10 to hydrate skin, increases fibronectin, and envelope proteins to improve corneocyte cohesion ...
Jørgen Frøkiær - Research outputs - Research - Aarhus University
Regulation and dysregulation of aquaporins in water balance disorders. / Nielsen, Søren; Kwon, TH; Frøkiær, Jørgen et al. ... Ovariectomy in rats is associated with increased renal aquaporin-2, -3, -1 and Na, K-ATPase expression and decreased urine ... 3, 2007, p. 192-204.. Research output: Contribution to journal/Conference contribution in journal/Contribution to newspaper › ...
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
The fact that H2O2 can diffuse reasonably far from its site of production and can use aquaporins to enter the cells suggest ... This is due to its high diffusion rate across membranes particularly through the use of aquaporins and its ability to target ... G. P. Bienert, A. L. B. Møller, K. A. Kristiansen et al., "Specific aquaporins facilitate the diffusion of hydrogen peroxide ... M. J. Marchissio, D. E. A. Francés, C. E. Carnovale, and R. A. Marinelli, "Mitochondrial aquaporin-8 knockdown in human ...
Gill transcriptome response to changes in environmental calcium in the green spotted puffer fish | BMC Genomics | Full Text
Cutler CP, Martinez AS, Cramb G: The role of aquaporin 3 in teleost fish. Comp Biochem Physiol A Mol Integr Physiol. 2007, 148 ... Giffard-Mena I, Boulo V, Aujoulat F, Fowden H, Castille R, Charmantier G, Cramb G: Aquaporin molecular characterization in the ... Figure 3. Relationship between relative change of gene expression measured by qPCR and SuperSAGE. Relative change of gene ... a transcript for an aquaporin form has been annotated to fish aqp3, using BlastX against fish proteins only. ...
Aquaporins in Melanocytic and Nonmelanocytic Skin Tumors
This study investigated the role of aquaporin 1 and aquaporin 3 in the pathobiology of skin cancers. Might they have potential ... Objectives: Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the ... Expression Pattern of Aquaporin 1 and Aquaporin 3 in Melanocytic and Nonmelanocytic Skin Tumors. ... Aquaporin (AQP) expression has been identified in various skin structures.[1] Specifically, AQP1 has been found in the ...
Aquaporin water channels - From atomic structure to clinical medicine<...
At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ... At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ... At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ... At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus ...
AQP3ProteinAQP2Aqp4AQP1Human aquaporinAntibodyExpression2021Aqp5HydrationArabidopsisPlant aquaporinGenesAqp6AQPs2017VasopressinAqp9GlycerolELISA KitKeratinocytesIncrease in aquaporinRole of aquaporinsPIP2KidneyAnti-aquaporinRegulationCollecting ductNephrogenic diabetesAstrocyticMechanismsFamily of ProteinsNeuromyelitisMissense mutationsMembranesTransmembraneLocalization2022KidneysSoluteDownregulation2002PermeabilityNMOSDSerumAdditionallyTransporterAqp11GlycineCerebral2020
AQP37
- Aquaporin 3 (AQP-3) is the protein product of the human AQP3 gene. (wikipedia.org)
- Study of aquaporin 1 (AQP1) and aquaporin 3 (AQP3) expression to understand its potential role in the pathophysiology of skin cancer. (medscape.com)
- The water/small solute-transporting protein aquaporin-3 (AQP3) was found by immunofluorescence and immunogold electron microscopy to be expressed at the plasma membrane of epidermal keratinocytes in mouse skin. (edu.sa)
- The present study aimed to investigate aquaporin (AQP1, AQP3 and AQP5) gene expression and cellular localization in response to cryoinjury. (bvsalud.org)
- Herein, we studied changes with age the water permeability (Pf) of the plasma membranes of the corneal endothelial cells and the level of expression in them of the mRNA genes of the water channels of the aquaporins AQP1 and AQP3 in Wistar and senescence-accelerated OXYS rats. (transhumanist.ru)
- The expression of aqp3 mRNA in the endothelium of 3-month-old OXYS rats was half that of Wistar rats and did not change with age, while in Wistar rats it decreased and at 18 months was 4 times lower than in 3 months. (transhumanist.ru)
- Additionally, orchid extracts provide skin hydration by stimulating aquaporin 3 (AQP3) and LEKTI protein expression. (jolispa.com)
Protein18
- The AQP2 gene provides instructions for making a protein called aquaporin 2. (medlineplus.gov)
- Most of the known AQP2 gene mutations cause the aquaporin 2 protein to be misfolded into an incorrect 3-dimensional shape. (medlineplus.gov)
- The water permeability of biological membranes has been a longstanding problem in physiology, but the proteins responsible for this remained unknown until discovery of the aquaporin 1 (AQP1) water channel protein. (elsevier.com)
- CO 2 permeability of plasma membrane intrinsic protein 2 (PIP2) aquaporins of Hordeum vulgare L. was investigated. (elsevier.com)
- Glycerol uptake facilitator protein 3. (lbl.gov)
- GATA binding protein 3 [Sourc. (gsea-msigdb.org)
- The remainder include heat shock transcription factor-4 ( HSF4 ), aquaporin-0, v-maf musculoaponeurotic fibrosarcoma oncogene homolog, paired-like homeodomain 3, beaded filament structural protein-2, chromatin modifying protein and lens intrinsic membrane protein 2 ( 4 ). (spandidos-publications.com)
- Glycine max endoplasmic reticulum-Golgi intermediate compartment protein 3-like (LOC100781612), mRNA. (go.jp)
- Investigation of the effects of aging on the expression of aquaporin 1 and aquaporin 4 protein in heart tissue. (transhumanist.ru)
- Aquaporin 6 is a protein in humans that is encoded by the AQP6 gene. (nsjbio.com)
- Skauli N , Savchenko E , Ottersen OP , Roybon L , Amiry-Moghaddam M . Canonical Bone Morphogenetic Protein Signaling Regulates Expression of Aquaporin-4 and Its Anchoring Complex in Mouse Astrocytes. (wjgnet.com)
- TIPs belong to MIP/aquaporin protein family. (agrisera.com)
- Here we show that NMO-IgG binds selectively to the aquaporin-4 water channel, a component of the dystroglycan protein complex located in astrocytic foot processes at the blood-brain barrier. (qxmd.com)
- Therefore, the effect of candesartan on UT-A1, UT-A3, NKCC2, and aquaporin-2 (AQP2) protein abundances was determined in control and 3-wk DM rats. (emory.edu)
- Immunohistochemistry using a combination of glial fibrillary acidic protein (GFAP) and aquaporin-4 antibodies were employed to follow changes in the optic nerve head astrocytes. (unthsc.edu)
- Results: In retinas of both injury models, there was an upregulation of GFAP (a marker of astrogliosis), caspase-3, and downregulation of thy-1, a marker for retinal ganglion cell stress, and decreased retinal AQP4 mRNA and protein levels as determined by Q-PCR, and western blotting, respectively. (unthsc.edu)
- Aquaporin 4 may be connected to the dystrophin-associated protein complex. (wikimili.com)
- [3] It is one of two protein complexes found in the costamere in striated muscle fibres . (wikimili.com)
AQP22
- Arginine-vasopressin (AVP) facilitates water reabsorption in renal collecting duct principal cells through regulation of the water channel aquaporin-2 (AQP2). (mdc-berlin.de)
- Vasopressin regulates renal water homeostasis via Aquaporins by regulating the permeability of the epithelium through activation of a signaling cascade leading to the phosphorylation of AQP2 and its translocation from intracellular vesicles to the apical membrane of collecting duct cells. (reactome.org)
Aqp410
- Aquaporin-4 (Aqp4), an astrocytic transmembrane water channel, is an important molecular contributor to cerebral edema formation. (biomedcentral.com)
- Aquaporin-4 (Aqp4) is a passive transmembrane water channel that in the central nervous system (CNS) is exclusively expressed by astrocytes, and is an important molecular contributor to cerebral edema formation after cerebral ischemia [ 27 - 31 ]. (biomedcentral.com)
- Neuromyelitis optica spectrum disorder (NMOSD) has emerged as a disorder distinct from multiple sclerosis, largely due to the discovery in 2004 of a novel disease marker, aquaporin-4 immunoglobulin or AQP4-IgG (also known as NMO-IgG). (bcmj.org)
- NMOSD affects more females than males,[ 5,6 ] is seen in mixed ethnic populations, and often involves the autoantibody aquaporin-4 immunoglobulin or AQP4-IgG (also known as NMO-IgG). (bcmj.org)
- 3 ] AQP4-IgG is a highly specific disease marker for NMOSD and helps distinguish the disorder from MS. Distinguishing NMOSD from MS is important for both prognosis and treatment because it has been observed that traditional MS immunomodulatory therapy may not be effective and may even worsen NMOSD. (bcmj.org)
- Changes in AQP4, caspase-3, thy-1, ubiquitination, and GFAP expression were also followed in total retinal extracts using western blotting. (unthsc.edu)
- Detection of IgG anti-Aquaporin-4 (AQP4) in serum of individuals with Neuromyelitis optica syndrome disorders (NMOSD) has improved diagnosis of these processes and differentiation from Multiple sclerosis (MS). transmission made reliable detection impossible. (welbourneprimary.com)
- As the clinical manifestations of NMOSD disease are comparable to those of MS, NMOSD has been misdiagnosed as a type of MS for many years until the identification of an anti NMO antibody known as anti-aquaporin (AQP4) in 2004 [ 3 , 4 ]. (biomedcentral.com)
- [6] NMO is characterized by a disease specific IgG antibody against the astrocytic aquaporin 4 (AQP4) water channel (also known as the aquaporin-4 autoantibody (anti-AQP4 or AQP4-IgG). (eyewiki.org)
- 2 , 3 Here, we describe a case of NMOSD with anti-aquaporin-4 (AQP4) antibodies who had a relapse with brainstem and cervical spinal cord lesions manifesting as short-lasting unilateral neuralgiform headache attacks with cranial autonomic symptoms (SUNA), a rare form of TAC. (neurology.org)
AQP14
- The keratinocytes exposure to LED-BL produced an increase of reactive oxygen species (ROS), an activation of 8-hydroxy-2'-deoxyguanosine (8-OHdG), an alteration of proliferating cell nuclear antigen (PCNA), and a down-regulation of AQP1, 3 and 9. (unict.it)
- These findings are preliminary evidences that may be used as starting points for further investigations about the mechanistic involvement of AQP1, 3, and 9 in LED-BL-induced skin aging. (unict.it)
- The expression of aqp1 mRNA (studied by RT-PCR) in the endothelium was the same in Wistar and OXYS rats at the age of 3 months. (transhumanist.ru)
- Aquaporin-1 (AQP1) in the proximal tubule and the descending thin limb of Henle is responsible for about 90% of reabsorption (as estimated from mouse knockouts of AQP1). (reactome.org)
Human aquaporin2
- Description: A sandwich quantitative ELISA assay kit for detection of Human Aquaporin 5 (AQP5) in samples from tissue homogenates, cell lysates or other biological fluids. (myelisakit.com)
- An amino acid sequence from the C-terminus of human Aquaporin 6 (EPLKKESQPGSGAVEMESV) was used as the immunogen for this Aquaporin 6 antibody. (nsjbio.com)
Antibody11
- Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Aquaporin 5 (AQP5) in saliva, tissue homogenates, cell lysates and other biological fluids. (myelisakit.com)
- Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Aquaporin 5 (AQP5) in samples from saliva, tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (myelisakit.com)
- This Aquaporin 6 antibody is available for research use only. (nsjbio.com)
- Titration of the Aquaporin 6 antibody may be required due to differences in protocols and secondary/substrate sensitivity. (nsjbio.com)
- After reconstitution, the Aquaporin 6 antibody can be stored for up to one month at 4oC. (nsjbio.com)
- 3. Interpret the outcomes associated with anti-aquaporin-4 and anti-myelin oligodendrocyte glycoprotein antibody positivity in adult optic neuritis. (utah.edu)
- Diluted antibody solution can be used 2 to 3 times within one month if it contains 0.1 % sodium azide as preservative and is stored at -20ºC to -80ºC. (agrisera.com)
- Neuromyelitis optica and anti-aquaporin 4 antibody--an overview]. (qxmd.com)
- Neuromyelitis optica and anti-aquaporin 4 antibody--distinct from multiple sclerosis]. (qxmd.com)
- METHODS: An international cohort of women with aquaporin-4 antibody-positive NMOSD and ≥1 pregnancy was studied retrospectively. (ox.ac.uk)
- Myelin oligodendrocyte glycoprotein (MOG) and serum aquaporin-4 antibody results were also negative. (fucoidanlongevity.com)
Expression15
- Suberoylanilide hydroxamic acid (SAHA) (a HDAC inhibitor) increases expression of aquaporin-3 in normal skin cells (keratinocytes). (wikipedia.org)
- Aquaporin (AQP) expression has been identified in various skin structures. (medscape.com)
- Aquaporin 3 Expression Predicts Survival in Patients with HER2-positive Early Breast Cancer. (cdc.gov)
- 4. Balarynová J, Danihlik J, Fellner M (2018) Changes in plasma membrane aquaporin gene expression under osmotic stress and blue light in tomato. (sciendo.com)
- Additionally, cells were transfected with small interfering RNA to silence aquaporin gene expression and cell viability was assessed using the Sulforhodamine B assay. (bvsalud.org)
- it increases the expression of Aquaporin 3 in cellular membranes for water transfer control in and out of the cells and guarantees maximum deep skin hydration and enhanced cell wellness. (pevoniapro.com)
- Rhubarb tannins extract inhibits the expression of aquaporins 2 and 3 in magnesium sulphate-induced diarrhoea model. (medicaljournalshouse.com)
- Increased Expression of Aquaporin 9 in Trophoblast From Gestational Diabetic Patients. (ivi-rmainnovation.com)
- Purpose: Changes in the expression of water channels or aquaporins (AQP) have been reported in several diseases. (unthsc.edu)
- J. BADAUT, S. ASHWAL, L.REGLI, B. TONE, H.R. TIAN, A.OBENAUS (2007) Temporal and Regional Evolution of Aquaporin 4 Expression and Magnetic Resonance Imaging in a Rat Pup Model of Neonatal Stroke. (llu.edu)
- M DE CASTRO RIBEIRO, L HIRT, J BOGOUSSLAVSKY, L REGLI and J BADAUT (2006) Time course of edema formation and brain aquaporin expression after transient focal cerebral ischemia in mice. (llu.edu)
- J. BADAUT, J.M. PETIT, J.F. BRUNET, P.J. MAGISTRETTI, C. CHARRIAUT-MARLANGUE AND L. REGLI (2004) Distribution of Aquaporin 9 in the adult rat brain: preferential expression in catecholaminergic neurons and in glial cells. (llu.edu)
- Um Hinweise auf die Funktion des Aquaporins in der Pflanze zu erhalten, wurde die Expression und Lokalisation von AtNIP1;1 untersucht. (tu-darmstadt.de)
- 2022. Na + /HCO 3 - cotransporter 1 ( nbce1 ) isoform gene expression during smoltification and seawater acclimation of Atlantic salmon. (skidmore.edu)
- Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis. (ki.se)
20211
- 2021 ;34(3):135-145. (greenmedinfo.com)
Aqp51
- Aquaporin-5 (AQP5) is one of a large family of proteins on cell membranes. (reviewofoptometry.com)
Hydration6
- Aquaporins (AQPs) are water membrane channels that permeate both water and glycerol and play an important role in the hydration of epidermis, as well as in proliferation and differentiation of keratinocytes. (unict.it)
- Reduced SC hydration was seen from 3 days after birth. (edu.sa)
- Glycerol replacement corrects defective skin hydration, elasticity, and barrier function in aquaporin-3-deficient mice. (transcendermal.com)
- The Aquaporin line is a burst of hydration for oily and acne-prone skin,' says Cho. (allure.com)
- Beyond these properties, APIOSKIN ® activates the biological levers of cutaneous hydration (aquaporins, osmolyte transporter, natural moisturizing factor). (silab.fr)
- Tested in vivo at 3% in Caucasian and Asian volunteers, the active ingredient thus provides a flash and long-lasting hydration to dehydrated skin, superficially and in depth (from the stratum corneum to the upper dermis). (silab.fr)
Arabidopsis4
- T. Li, W.G. Choi, I.S. Wallace, J. Baudry, and D.M. Roberts (2011) Arabidopsis thaliana NIP7;1: an anther-specific boric acid transporter of the aquaporin superfamily regulated by an unusual tyrosine in helix 2 of the transport pore. (utk.edu)
- Arabidopsis seed-specific vacuolar aquaporins are involved in maintaining seed longevity under the control of ABSCISIC ACID INSENSITIVE 3. (agrisera.com)
- Im Rahmen dieser Arbeit sollte das zu dieser Familie gehörende Arabidopsis thaliana Aquaporin AtNIP1;1 funktionell charakterisiert werden. (tu-darmstadt.de)
- The aim of the thesis was the functional characterization of the Arabidopsis thaliana NIP-aquaporin AtNIP1;1. (tu-darmstadt.de)
Plant aquaporin2
- 16. Fox AR, Maistriaux LC, Chaumont F (2017) Toward understanding of the high number of plant aquaporin isoforms and multiple regulation mechanisms. (sciendo.com)
- The plant aquaporin family of the Nodulin26-like intrinsic proteins was named because of the high structural and functional similarity to soybean Nodulin 26. (tu-darmstadt.de)
Genes2
- Defects in aquaporin genes can cause disease. (reviewofoptometry.com)
- Diurnal transcription patterns of aquaporin genes were measured showing that a total of 34 genes belonging to 4 aquaporin families were expressed in soybean leaves, of which 22 were differentially expressed between at least two time points. (usda.gov)
Aqp61
- Unlike other aquaporins, AQP6 functions not as a water channel but as an anion-selective channel. (nsjbio.com)
AQPs3
- Aquaporins (AQPs) are a family of channel proteins that facilitate water transportation across cell membranes. (frontiersin.org)
- The aquaporins (AQPs) are a family of water-transporting proteins that facilitate osmotically driven water movement across cell plasma membranes. (nsjbio.com)
- Aquaporins (AQPs) are homotetrameric channel proteins allowing the diffusion of water/small solutes across membranes. (uniba.it)
20171
- 2017). Here, aquaporins contribute to the signalling pathway of this stress hormone by facilitating the entry of hydrogen peroxide in the guard cell. (inra.fr)
Vasopressin3
- In the kidney, aquaproin-3 is unresponsive to the antidiuretic hormone vasopressin, unlike aquaporin-2. (wikipedia.org)
- Requirement of human renal water channel aquaporin-2 for vasopressin-dependent concentration of urine. (medlineplus.gov)
- Robben JH, Knoers NV, Deen PM. Cell biological aspects of the vasopressin type-2 receptor and aquaporin 2 water channel in nephrogenic diabetes insipidus. (medlineplus.gov)
Aqp92
- During Transport of glycerol from adipocytes to the liver by Aquaporins, glycerol generated by triglyceride hydrolysis is exported from adipocytes by AQP7 and is imported into liver cells via AQP9. (reactome.org)
- Induction of brain aquaporin 9 (AQP9) in catecholaminergic neurons in diabetic rats. (llu.edu)
Glycerol6
- One study examined the roles of aquaporin 3 and aquaporin 10, which are water/glycerol channel proteins located in the epidermis, and concluded that overexpression of these channels may play a role. (medscape.com)
- At least 10 mammalian aquaporins have been identified, and these are selectively permeated by water (aquaporins) or water plus glycerol (aquaglyceroporins). (elsevier.com)
- Nodulin-26 aquaporin and glycerol facilitator, NIP (de Paula Santos Martins et al. (lbl.gov)
- Hg2+-inhibitable aquaporin, AqpM (transports both water and glycerol as well as CO2) (Kozono et al. (lbl.gov)
- Glycerine is a 3-carbon alcohol, aka glycerol. (averycountycycles.com)
- These lipids are constructed upon an sn-glycerol-3-phosphate backbone scaffold by the attachment of long-chain acyl and alkyl groups, and a collection of polar alcohols. (averycountycycles.com)
ELISA Kit1
- Description: A sandwich ELISA kit for detection of Aquaporin 5 from Mouse in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (myelisakit.com)
Keratinocytes1
- The Science: This ingredient increases the levels of Aquaporin 3 in keratinocytes, aquaglyceroporin responsible for ensuring the transport of water and then, contributing to maintaining skin barrier integrity. (madeinyouthland.com)
Increase in aquaporin1
- An increase in aquaporin (AQP) 3 is cryoprotective, whereas its inhibition augments cryodamage. (bvsalud.org)
Role of aquaporins1
- Role of aquaporins for cornea endothelium function, as well as age-related changes of their activity, are not entirely understood. (transhumanist.ru)
PIP23
- The isoleucine residue at position 254 of HvPIP2;3 was conserved in PIP2 aquaporins of barley, except HvPIP2;4, which possesses methionine instead. (elsevier.com)
- These results suggest that PIP2 aquaporins are permeable to CO 2 . (elsevier.com)
- 15. Ding L, Uehlein N, Kaldenhoff R, Guo S, Zhu Y, Kai L (2019) Aquaporin PIP2;1 affects water transport and root growth in rice ( Oryza sativa L.). Plant Physiology and Biochemistry 139:152-160. (sciendo.com)
Kidney2
- Branchial Ca 2+ uptake appears to occur mainly through specialized mitochondrion-rich cells (MR cells) or "chloride cells" following a 3-step process similar to that proposed for Ca 2+ reabsorption in the mammalian kidney: passive entry of Ca 2+ through apical epithelial Ca 2+ channels (e.g. (biomedcentral.com)
- ClC-1 ( UniProt P35523) is involved in setting and restoring the resting membrane potential of skeletal muscle, while other channels play important parts in solute concentration mechanisms in the kidney [3]. (bionity.com)
Anti-aquaporin1
- Anti-aquaporin-4 auto-antibodies orchestrate the pathogenesis in neuromyelitis optica. (qxmd.com)
Regulation3
- These processes are linked to the regulation of aquaporins, membrane channel proteins that facilitate the transport of water across cell membranes. (inra.fr)
- To date, H 2 O 2 -dependent signaling has been shown to play a key role in the regulation of many cellular processes including differentiation, proliferation, migration, and apoptosis [ 3 , 7 - 9 ]. (hindawi.com)
- Aquaporin Regulation. (skidmore.edu)
Collecting duct4
- This hormone triggers chemical reactions that ultimately insert aquaporin 2 water channels into the membrane of collecting duct cells. (medlineplus.gov)
- Without signals from ADH, aquaporin 2 water channels are removed from the membrane of collecting duct cells. (medlineplus.gov)
- If aquaporin 2 water channels are not inserted into the membrane of collecting duct cells, the kidneys are unable to respond to signals from ADH. (medlineplus.gov)
- Histological examination reveals that these cysts are collecting duct in origin, staining positively for aquaporin-2 and -3. (biomedcentral.com)
Nephrogenic diabetes2
- Loonen AJ, Knoers NV, van Os CH, Deen PM. Aquaporin 2 mutations in nephrogenic diabetes insipidus. (medlineplus.gov)
- In humans, mutations in the aquaporin-2 gene lead to hereditary nephrogenic diabetes insipidus. (reviewofoptometry.com)
Astrocytic1
- J.BADAUT, S. ASHWAL, A ADAMI, B TONE, B RECKER, B TERNON, A. OBENAUS (2010) Brain water mobility decreases after astrocytic aquaporin-4 inhibition using RNA interference. (llu.edu)
Mechanisms3
- Agre, P. & Kozono, D. Aquaporin water channels: molecular mechanisms for human diseases. (nature.com)
- Morishita, Y., Sakube, Y., Sasaki, S. & Ishibashi, K. Molecular mechanisms and drug development in aquaporin water channel diseases: aquaporin superfamily (superaquaporins): expansion of aquaporins restricted to multicellular organisms. (nature.com)
- cAMP-dependent mechanisms or PKA activate the aquaporin channel. (springer.com)
Family of Proteins1
- The family of proteins to which aquaporins belong sometimes goes by the name integral membrane proteins (IMP) or major intrinsic proteins (MIP). (reviewofoptometry.com)
Neuromyelitis3
- Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis. (qxmd.com)
- Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis. (qxmd.com)
- Pregnancy outcomes in aquaporin-4-positive neuromyelitis optica spectrum disorder. (ox.ac.uk)
Missense mutations1
- Here, we describe novel zebrafish mau mutants, which encompass several dominant missense mutations in Aquaporin 3a (Aqp3a) that lead to broken stripes and short fins. (nih.gov)
Membranes5
- Diagram illustrating the structural mechanism of aquaporin gating in plant plasma membranes. (nature.com)
- Johansson, I., Larsson, C., Ek, B. & Kjellbom, P. The major integral proteins of spinach leaf plasma membranes are putative aquaporins and are phosphorylated in response to Ca 2+ and apoplastic water potential. (nature.com)
- This is due to its high diffusion rate across membranes particularly through the use of aquaporins and its ability to target reactive/REDOX sensitive cysteine residues in proteins [ 1 - 6 ]. (hindawi.com)
- Aquaporins (AQP's) are six-pass transmembrane proteins that form channels in membranes. (reactome.org)
- The team is mimicking the way diatoms form their cell wall out of silica and utilizing aquaporins, proteins that transport pure water across cell membranes throughout nature. (learnbiomimicry.com)
Transmembrane2
- 10. Bienert GP, Chaumont F (2014) Aquaporin-facilitated transmembrane diffusion of hydrogen peroxide. (sciendo.com)
- 11. Bienert GP, Heinen RB, Berny MC, Chaumont F (2014) Maize plasma membrane aquaporin ZmPIP2;5, but not ZmPIP1;2, facilitates transmembrane diffusion of hydrogen peroxide. (sciendo.com)
Localization1
- Localization of aquaporins was studied using immunocytochemistry. (bvsalud.org)
20221
- 2022 Jun 1;34(3):133-137. (ivi-rmainnovation.com)
Kidneys3
- There are 13 known aquaporins, many of which are found in the kidneys. (reviewofoptometry.com)
- The kidneys regenerate the HCO 3 - consumed during this reaction. (medscape.com)
- This reaction continues to move to the left as long as CO 2 is constantly eliminated or until HCO 3 - is significantly depleted, making less HCO 3 - available to bind H + . That HCO 3 - and PaCO 2 can be managed independently (by kidneys and lungs, respectively) makes this a very effective buffering system. (medscape.com)
Solute2
- 18. Gomes D, Agasse A, Thiébaud P, Delrot S, Gerós H, Chaumont F (2009) Aquaporins are multifunctional water and solute transporters highly divergent in living organisms. (sciendo.com)
- Aquaporins are important in fluid and solute transport in various tissues. (reactome.org)
Downregulation1
- Downregulation of aquaporin 3 inhibits cellular proliferation, migration and invasion in the MDA‑MB‑231 breast cancer cell line. (aston.ac.uk)
20023
- 2002 Jul 1;542(1):3-16. (elsevier.com)
- J. BADAUT, F. LASBENNES, P.J. MAGISTRETTI and L. REGLI (2002) Aquaporins in brain: distribution, physiology and pathophysiology. (llu.edu)
- Over 10,000 birds of more than 150 species have been captured, sampled, and released at 20 federal sites and 3 other sites in 12 states during the spring and fall bird migration seasons of 2001 and 2002. (cdc.gov)
Permeability1
- CO 2 permeability was lost by the substitution of the Ile254 of HvPIP2;3 by methionine, while water permeability was not affected. (elsevier.com)
NMOSD3
- 3 ] In NMOSD, spinal cord lesions can be seen on MRI to extend over three or more spinal segments. (bcmj.org)
- Pregnancies conceived after, or up to 3 years before, NMOSD onset had an increased odds ratio of miscarriage (7.28 [1.03-51.6] and 11.6 [1.05-128], respectively), independent of maternal age or history of miscarriage. (ox.ac.uk)
- She was diagnosed as having NMOSD and treated with intravenous methylprednisolone (IV-MP, 1,000 mg/d for 3 days). (neurology.org)
Serum1
- 6,7 ] This serum autoantibody targets the aquaporin-4 water channel and induces a series of biological events that result in tissue inflammation, demyelination, and edema. (bcmj.org)
Additionally1
- Additionally, a conserved cysteine residue is present about 9 amino acids downstream from the second NPA box and this cysteine is considered indicative of group III aquaporins. (reactome.org)
Transporter1
- Glycine max inorganic phosphate transporter 1-3 (PHT1-3), mRNA. (go.jp)
Aqp111
- AQP11 and AQP12, classified as group III aquaporins, were identified as a result of the genome sequencing project and are characterized by having variations in the first NPA box when compared to more traditional aquaporins. (reactome.org)
Glycine5
Cerebral1
- Taken together, these 3 papers provide novel and converging evidence that, clinically, cerebral amyloid angiopathy should be considered as a cause in patients above the age of 60 years with stereotyped episodes of focal neurological loss and cognitive decline and superficial siderosis on MRI, even in the absence of other MRI abnormalities, in particular if the distribution of the siderosis is mainly supratentorial. (bmj.com)
20201
- 2020. Hormonal control of aquaporins in fishes. (skidmore.edu)