A general term collectively applied to tumors associated with the APUD CELLS series, irrespective of their specific identification.

Recombinant interferon alpha-2b in patients with metastatic apudomas: effect on tumours and tumour markers. (1/17)

Malignant carcinoid tumours, islet cell tumours and medullary carcinomas of the thyroid are tumours with similar clinical features. In patients with unresectable or metastatic tumours leukocyte interferon (IFN) and recombinant human (rh) IFN have demonstrated efficacy. Twenty-four evaluable patients with progressive tumours were treated with 2.5 megaunits rh IFN alpha-2b, administered once daily subcutaneously, for a median duration of 7 months (range 0.5-37+). Two carcinoid patients demonstrated a response in tumour size, 80% showed stable disease (SD). Sixty percent of the carcinoid patients with elevated urinary 5-hydroxyindoleacetic (5-HIAA) levels reached a biochemical partial response of the urinary 5-HIAA levels (median duration 13.5 months). In the patients with an islet cell or medullary tumour and an elevated tumour marker, the marker did not further increase. Of the 12 carcinoid patients evaluable for a symptomatic response, ten (83%) experienced a relieve of symptoms. IFN alpha-2b dose reduction or discontinuation due to toxicity was necessary in three and ten patients, respectively. No neutralising IFN alpha-2b antibodies developed despite prolonged treatment. In conclusion, IFN alpha-2b had a beneficial effect in patients with progressive tumours, while long-term IFN alpha-2b treatment did not augment neutralising antibodies. In view of the IFN alpha-2b-related toxicity, administration of IFN alpha-2b on alternating days may be preferable.  (+info)

Relative usefulness of electron microscopy and immunocytochemistry in tumour diagnosis: 10 years of retrospective analysis. (2/17)

AIMS: To determine retrospectively the relative usefulness of electron microscopy and immunocytochemistry for tumour diagnosis; to monitor the influence of new antibodies and antisera on the use of these techniques in one laboratory. METHODS: During 1980 to 1989 inclusive, 726 tumours were examined by electron microscopy, 862 by immunocytochemistry, and 286 by both techniques. The choice of techniques and, for immunocytochemistry, the range of antibodies used were compared between each category of final diagnosis. RESULTS: During the study period there was a sharp fall in the use of electron microscopy and a corresponding rise in immunocytochemistry. These trends applied to all categories of final tumour diagnosis, but the use of electron microscopy was sustained longer for lesions suspected or eventually confirmed to be melanomas or amine precursor uptake decarboxylation cell carcinoma (APUDomas)--for example, carcinoid tumours. The immunocytochemistry:electron microscopy use ratios ranged from 2.07:1 to 0.44:1 for the categories in which lymphoma and APUDoma, respectively, were the final diagnoses. The abandonment of electron microscopy for suspected or confirmed lymphomas and carcinomas corresponded to the increasing availability of relevant antisera and antibodies. CONCLUSIONS: The wider application of immunocytochemistry for tumour diagnosis is endorsed, but electron microscopy should be retained for selected cases in which the results of immunocytochemistry might be predictably ambiguous or otherwise unhelpful.  (+info)

Production of calcitonin, adrenocorticotropic hormone, and beta-melanocyte-stimulating hormone in tumors derived from amine precursor uptake and decarboxylation cells. (3/17)

The tumor production of human calcitonin (CT) was examined by radioimmunoassay, and it was found that 50 of 85 (59%) tumor tissues collected at random contained immunoreactive CT. These tumors were grouped as to whether they were derived from the amine precursor uptake and decarboxylation (APUD) series. The group that was derived from APUD cells showed appreciable amounts of CT in 30 of 31 (97%) of these tumors or in 20 of 21 (95%) when the medullary carcinomas of the thyroid were excluded. However, of the non-APUD group of tumors only 20 of 54 (37%) were found to contain CT, so that the difference between these two groups was highly significant (p less than 0.001). Of the tumors with ectopic adrenocorticotropic hormone-melanocyte-stimulating hormone production, 12 of 14 were shown to contain CT. These data indicate that CT is a common product of the APUD tumors and that tumor production of CT is often associated with that of adrenocorticotropic hormone and beta-melanocyte-stimulating hormone.  (+info)

Cyclical release of vasoactive intestinal polypeptide (VIP) from a pancreatic islet cell apudoma. (4/17)

A patient is described who presented with the classical symptomatology and profound electrolyte disturbance of the Verner-Morrison syndrome due to a pancreatic apudoma secreting vasoactive intestinal polypeptide (VIP). Diagnosis was confirmed by plasma VIP as measured by a radio-immunoassay technique now available. It is suggested that the cyclical nature of the symptoms in this case was due to cyclical release of VIP from the tumour in response to an unknown stimulus. Perfusion studies confirmed the excess secretory state of water, sodium and chloride in the small intestine. Symptoms were completely abolished by surgery and the progress is being monitored by means of serial plasma VIP estimations to detect any early recurrence of metastatic disease.  (+info)

Apudoma of the pancreas: benign or malignant? (5/17)

A middle-aged, obese, black woman complained of abdominal pain and tenderness in the left upper quadrant. An abdominal computerized tomographic (CT) scan revealed an encapsulated cystic mass in the tail region of the pancreas. Selective angiography confirmed mass and hypervascularity, definite encapsulation, and lack of capsular invasion. The diagnostic value of the CT scan, angiography, and special staining in classifying the excised pancreatic mass as an apudoma is discussed. Malignancy was excluded by the lack of capsular-vascular invasion and the absence of metastases. Nonfunctional status was determined by lack of hormone hypersecretion.  (+info)

ACTH-producing apudoma metastatic to the liver. (6/17)

A young man presented with combative psychosis and elevated levels of plasma adrenocorticotropic hormone (ACTH). A solitary vascular pancreatic mass and diffuse vascular hepatic nodules were demonstrated on selective splenic and hepatic arteriograms. These classic angiographic findings are used to emphasize the role of angiography in initial radiographic evaluation and to summarize the angiographic appearance of functioning pancreatic adenomas. Even though this is an aggressive tumor, early diagnosis and intensive treatment may allow prolonged remission, if not cure.  (+info)

Iodine-131 MIBG scintigraphy of neuroendocrine tumors other than pheochromocytoma and neuroblastoma. (7/17)

Metaiodobenzylguanidine (MIBG) locates most pheochromocytomas and neuroblastomas. The tracer is concentrated in intracellular storage vesicles by an active process. Many other neuroendocrine tumors of the amine precursor uptake and decarboxylation (APUD) series have hormonal storage vesicles and, thus, the potential to take up [131I]MIBG. A variety of neuroendocrine tumors in 57 patients were studied 1, 2, and 3 days after 0.5 mCi [131I]MIBG. Views from skull to pelvis were obtained. Results of MIBG scans were compared with all available imaging modalities (including plain radiography, liver scan, ultrasound, computed tomography, and angiography) and surgical exploration. The neuroendocrine nature of the tumor was determined by histology, immunohistochemistry, electron microscopy, and the assay of appropriate biogenic amines and peptide hormones. Results were (positive/total cases): carcinoids (four of ten), nonsecreting paragangliomas (three of three), sporadic medullary carcinomas of the thyroid (MCT) (one of five), familial MCT (one of 26), chemodectomas (two of five), oat cell carcinomas (zero of four), choriocarcinoma (one of one), atypical schwannoma (with storage granules) (one of one), Merkel cell skin cancer (one of one), islet cell carcinoma (zero of one). We conclude that a wide range of neuroendocrine tumors show [131I]MIBG uptake; tumors other than pheochromocytomas and neuroblastomas are less often seen scintigraphically, but in certain cases (e.g., carcinoid and nonsecreting paragangliomas) scintigraphy may be useful in depicting the extent and location of disease and may indicate therapeutic potential. Iodine-131 MIBG shows promise in the diagnosis and staging of tumors of varied types.  (+info)

Neuroendocrine (Merkel cell) carcinoma of the skin. Its natural history, diagnosis, and treatment. (8/17)

Over 400 cases of neuroendocrine (Merkel cell) carcinoma of the skin (NCS) have been reported. This tumor continues to pose problems in diagnosis and effective treatment for physicians unfamiliar with its biological characteristics. Reported here are five additional cases of NCS and the literature for this rare neoplasm is comprehensively reviewed. An early and accurate diagnosis is made possible by combining clinical presentation with results of histologic study, immunoperoxidase staining for neuron-specific enolase (NSE), epithelial membrane antigen (EMA), cytokeratins, and electron microscopy. NCS is an aggressive tumor. Depending on the length of follow-up, up to 40% of tumors locally recur, 55% develop regional nodal metastases, and 36% undergo distant metastasis. Survival is sex, but not age, dependent, with an overall 2-year survival rate of 72% (males 58% vs. females 79%). No standard procedure for initial and/or follow-up treatment for NCS exists. The authors recommend that NCS be treated, whenever possible, using the same rationale as applied for the treatment of squamous cell carcinoma of the skin.  (+info)

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neuroendocrine adenoma OR neuroendocrine adenomas OR neuroendocrine tumor OR neuroendocrine tumors OR neuroendocrine cancer OR neuroendocrine cancers OR neuroendocrine carcinoma OR neuroendocrine carcinomas OR neuroendocrine neoplasm OR neuroendocrine neoplasms OR ((Cushings syndrome OR Kulchitsky cell) AND (adenoma[tiab] OR adenomas[tiab] OR tumor[tiab] OR tumors[tiab] OR cancer[tiab] OR cancers[tiab] OR carcinoma[tiab] OR carcinomas[tiab] OR neoplasm[tiab] OR neoplasms[tiab] OR neoplastic[tiab] OR malign* OR metastas* OR metastat*)) OR carcinoid*[ti] OR vipoma* OR Verner-Morrison syndrome OR pancreatic cholera OR WDHA[tiab] OR watery diarrhea hypokalemia and achlorhydria syndrome OR apudoma* OR gastrinoma* OR Zollinger-Ellison syndrome OR insulinoma*[ti] OR Glucagonoma* OR Somatostatinoma* OR GRFoma* OR ACTHoma* OR PPoma* OR islet cell tumor[ti] OR islet cell tumors[ti] OR pancreatic endocrine tumor OR pancreatic endocrine tumors OR Merkel cell ...
Merkel-cell carcinoma is a rare and highly aggressive skin cancer, which, in most cases, is caused by the Merkel cell polyomavirus (MCV) discovered by scientists at the University of Pittsburgh in 2008. It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. ...
Merkel-cell carcinoma is a rare and highly aggressive skin cancer, which, in most cases, is caused by the Merkel cell polyomavirus (MCV) discovered by scientists at the University of Pittsburgh in 2008. It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. ...
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In evaluating patients with a potential brain tumor diagnosis, members of Lahey Hospital & Medical Center s Brain Tumor Clinic will review the individual s medical history, perform a neurologic exam, and order imaging studies such as a CT scan or MRI. A biopsy may also be performed to confirm the diagnosis.
Maria Menounos opens up about unbelievable brain tumor diagnosis, steps down from job at E!. Maria Menounos has revealed she was diagnosed with a brain tumor and will step down from her position as co-anchor of E! News.
‘Shocking’ delays to brain tumour diagnoses in the UK will be investigated as part of a new drive to tackle the disease.
Unusual cell that is pre-cancerous pertaining to cervical cancer tumors are far more regular and serious in females that are HIV-positive. See reality sheet 510 to find out more. More ladies are becoming contaminated with HIV. With very very early treatment and testing, females with HIV can live so long as males. Ladies should get tested for HIV. This is also true for women that are pregnant and females considering maternity. When they test good for HIV, they are able to make a plan to lessen the possibility of infecting their infants and make sure their very own wellness. The easiest way to stop illness in heterosexual intercourse is to use condoms. Other birth prevention practices usually do not drive back HIV. PrEP medicine can further reduce steadily the threat of HIV in females prone to HIV disease. Ladies who utilize intravenous medications must not share gear. Females pregnancy that is planning seek care just before getting pregnant to make sure a healthy body and evaluate their HIV ...
Looking into your microscope, you spot an unusual cell. Instead of the typical rounded cell shape, the cell has a very narrow middle separating two bulging ends. It sort of looks like the number 8! Then you realize that this cell ...
Chloe Wickham, 17, was having her hair cut in September 2016 when the hairdresser noticed a strange bump on the back of her head.
Affiliation (Current):鹿児島大学,理工学域工学系,助教, Research Field:Living organism molecular science,Bio-related chemistry,Tumor diagnosis, Keywords:コンドロイチン硫酸,デルマタン硫酸,糖鎖合成,神経突起伸長活性,糖鎖,生理活性,有機化学,神経科学,グリコサミノグリカン,系統的合成, # of Research Projects:3, # of Research Products:84
Merkel cell carcinoma (also known as a Cutaneous apudoma, Primary neuroendocrine carcinoma of the skin, Primary small cell carcinoma of the skin, and Trabecular carcinoma of the skin is a rare and highly aggressive cancer in which malignant cancer cells develop on or just beneath the skin and in hair follicles.. • The majority of Merkel cell carcinomas appear to be caused in part by a newly discovered virus, Merkel cell polyomavirus or MCV. Direct evidence for this comes from studies showing that inhibition of MCV proteins causes MCV-infected Merkel carcinoma cells to die but has no effect on tumor cells from Merkel cell carcinomas that are not infected with the virus. • This cancer is a type of neuroendocrine tumor, like small cell lung cancer. Once it has metastasized to the lymph nodes, the 5-year survival rate for a patient is about 50 percent. A patient with a small tumor (less than 2 cm) that has not metastasized to the lymph nodes may have a 5-year survival rate of more than 80 ...
Esthesioneuroblastoma has been reported to originate from sphenopalatine ganglion, vomeronasal organ of Jacobson, neuroepithelial cells of the olfactory membrane, the ectopic olfactory epithelium in the nasal mucosa and the amine precursor uptake and decarboxylation cells [1, 2]. It is a locally infiltrating malignant neoplasm; frequently invades the skull base, orbit and adjacent soft tissue from the typical cribriform site. In our patient, the neoplasm has infiltrated the left orbit through destruction of medial orbital wall resulting in proptosis. Distant and regional metastases are seen in about 14-38% of cases at the time of diagnosis; cervical lymph nodes, lung and bone being the frequently involved sites [4]. Esthesioneuroblastoma should be differentiated from other malignant tumors in anterior skull base.. CT and magnetic resonance imaging (MRI) are helpful to identify the margin and spread approaches of the tumor. Fine-cut CT scan (3 mm slice thickness) with direct coronal imaging is ...
A chromophil biological cell is a cell which is easily stainable by absorbing chromium salts used in histology to increase the visual contrast of samples for microscopy. Chromophil cells are mostly hormone-producing cells containing so-called chromaffin granules. In these subcellular structures, amino acid precursors to certain hormones are accumulated and subsequently decarboxylated to the corresponding amines, for example epinephrine, norepinephrine, dopamine or serotonin. Chromophil cells therefore belong to the group of APUD (amine precursor uptake and decarboxylation) cells. These cells are scattered throughout the whole body, but particularly in glands such as the hypothalamus, hypophysis, thyroid, parathyroid and pancreas ...
If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Centers RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.. ...
Cytokinesis is often mistakenly thought to be the final part of telophase; however, cytokinesis is a separate process that begins at the same time as telophase. Cytokinesis is technically not even a phase of mitosis, but rather a separate process, necessary for completing cell division. In animal cells, a cleavage furrow (pinch) containing a contractile ring develops where the metaphase plate used to be, pinching off the separated nuclei.[17] In both animal and plant cells, cell division is also driven by vesicles derived from the Golgi apparatus, which move along microtubules to the middle of the cell.[18] In plants this structure coalesces into a cell plate at the center of the phragmoplast and develops into a cell wall, separating the two nuclei. The phragmoplast is a microtubule structure typical for higher plants, whereas some green algae use a phycoplast microtubule array during cytokinesis.[19] Each daughter cell has a complete copy of the genome of its parent cell. The end of cytokinesis ...
books.google.comhttps://books.google.com/books/about/Immunocytochemistry_in_tumor_diagnosis.html?id=IpJrAAAAMAAJ&utm_source=gb-gplus-shareImmunocytochemistry in tumor diagnosis ...
books.google.comhttps://books.google.com/books/about/Immunocytochemistry_in_tumor_diagnosis.html?id=IpJrAAAAMAAJ&utm_source=gb-gplus-shareImmunocytochemistry in tumor diagnosis ...
Benign ovarian tumours diagnosis (costs for program #143611) ✔ Academic Hospital Harlaching ✔ Department of Gynecology, Mammology and Obstetrics ✔ BookingHealth.com
Benign vulvar tumor diagnosis (costs for program #214381) ✔ Clinique Générale ✔ Department of Gynecology ✔ BookingHealth.com
Granulocyte-macrophage colony-stimulating factor (GM-CSF, sargramostim [Leukine]) is a powerful cytokine that is able to stimulate the generation of dendritic cells. Adjuvant treatment with continuous lowdose GM-CSF has been shown to prolong survival of stage III/IV melanoma patients. Data on continuous low-dose GM-CSF therapy in tumors other than prostate cancer are still lacking. 1
Publications COLUMBIA UNIVERSITY (28 TOTAL) Kang, W.H., Simon, M.J., Gao, S., Banta, S., and Morrison III, B. (2011) Attenuation of astrocyte activation by TAT mediated delivery of a peptide JNK inhibitor Journal of Neurotrauma (In Press). Kim, Y.H., and Banta, S. (2011) A self-assembling hydrogel created from three modified dehydrogenases enables the complete oxidation of methanol in an enzymatic biofuel cell Angewandte Chemie International Edition (In Press). (Recognized as VIP publication) Szilvay, G.R., Brocato, S., Ivnitski, D., Li, C., DeLa Iglesia, P., Lau, C., Chi, E., Werner-Washburne, M., Banta, S., and Atanassov, P. (2011) Engineering of a redox protein for DNA-directed assembly Chemical Communications (In Press) Gao, S., Simon, M.J., Hue, C.D., Morrison III, B., and Banta, S. (2011) An unusual cell penetrating peptide identified using a plasmid display-based functional selection platform ACS Chemical Biology (In Press). (Recommended by Faculty of 1000, Featured in ...
Leukemias are cancers of the blood and happen when there is an excess amassing of strange (juvenile) blood cells (called blasts). Instead of developing regularly, expansive numbers of these blast cells transform into irregular white blood cells. These unusual cells cant complete the ordinary functions of white blood cells. They swarm the bone marrow and spill into the blood and may then spread into organs such as the liver, spleen, lungs, kidneys and into the cerebro spinal liquid to the brain.. Causes. In leukemia, the cells dont develop legitimately yet keep on reproducing and these strange cells spilling over into the blood supplant the bone marrow. Because the bone marrow can no more create sufficient ordinary blood cells and platelets, frailty, infections and bruising occurs.. Diagnosis and treatment. Leukemia occurs in several forms. Some forms show up suddenly and progress quickly over days to weeks. These are called acute leukemias. Others are less obvious and progress slowly over ...
help few you stand the download heterogenized homogeneous catalysts for fine chemicals production: materials and processes and endoproteinase figures( if financial). In The impression of Science, John Horgan is the centrifugation that the something of radioactively popular disparate Questions about the progress and our spectrometer in it leads even. getting immediate Voices many as Stephen Hawking, Francis Crick, and Richard Dawkins, he does that all the unusual cells that can average minded Are removed obtained, as download heterogenized homogeneous catalysts for fields thereby against Initial derivatives.
Unusual cell that is pre-cancerous pertaining to cervical are far more regular and serious in females whore HIV-positive. See reality sheet 510 to find out more. More women can be becoming contaminated with HIV. With very early treatment and testing, ladies with HIV can live so long as males. Ladies should get tested for HIV. This is especially valid for women that are pregnant and ladies considering maternity. When they test positive for HIV, they are able to make a plan to cut back the possibility of infecting their children and make sure their very own wellness. The way that is best to stop illness in heterosexual intercourse is with condoms. Other birth prevention practices usually do not drive back HIV. PrEP medicine can further reduce steadily the threat of HIV in females prone to HIV infection. Ladies who utilize intravenous medications must not share gear. Ladies preparing maternity should look for care just before getting pregnant to make sure a healthy body and evaluate their HIV ...
If you suspect you may have a brain tumour, it is important to go see your doctor who may recommend tests. Learn more about how a brain tumour is diagnosed.
Method and apparatus for extraction of breast tumors from three-dimensional ultrasonic images obtained by interpolation of a series of cross sectional images. The method consists of two stages are disclosed. In the first stage a membership function is automatically generated by using an output of three dimensional LoG(Laplace of Gaussian) filtering for the voxel data. In the second stage, the membership function is used for a fuzzy logic based calculation to produce three grades of the voxel attributable to three classes of
Oxfords Isis Innovation and Canadas Centre for Imaging Technology Commercialization (CIMTEC) partner to develop superior imaging technology
Affiliation (Current):東京大学,医学部附属病院,准教授, Research Field:Digestive surgery,Tumor diagnosis,Experimental pathology,Tumor therapeutics,Basic Section 50020:Tumor diagnostics and therapeutics-related, Keywords:胃癌,胃,胃発癌,腸上皮化生,胃炎,クローナリティ,腹膜播種,内照射,女性医師,クローナリテイ, # of Research Projects:12, # of Research Products:72, Ongoing Project:Collaborative Therapeutic Isotope Production and Radiopharmaceutical Synthesis
In his latest memoir, the actor and activist describes how a 2018 fall and a benign tumor diagnosis helped shape his new outlook on life.
Looking for online definition of cellular oncogene c-fos in the Medical Dictionary? cellular oncogene c-fos explanation free. What is cellular oncogene c-fos? Meaning of cellular oncogene c-fos medical term. What does cellular oncogene c-fos mean?
Carcinoid tumors are a type of neuroendocrine tumor that can occur in a number of locations. Carcinoid tumors arise from endocrine amine precursor uptake and decarboxylation (APUD) cells that can be found throughout the gastrointestinal tract as well as other organs (e.g. lung). In general, they are slow-growing tumors but are nevertheless capable of metastasizing.. ...
Small cell carcinomas (SCC) commonly arise in the respiratory tract; however, it is not uncommon for these cells to arise in nonpulmonary sites, as extrapulmonary small cell carcinoma (EPSCC). Small cell carcinoma is a distinct clinical and pathologic entity that arises from cells of the amine precursor uptake and decarboxylation (APUD) system.
Small cell carcinomas (SCC) commonly arise in the respiratory tract; however, it is not uncommon for these cells to arise in nonpulmonary sites, as extrapulmonary small cell carcinoma (EPSCC). Small cell carcinoma is a distinct clinical and pathologic entity that arises from cells of the amine precursor uptake and decarboxylation (APUD) system.
Yellow, cancerous tumors of hormone-making cells in the gastrointestinal tract (specifically, they are classed as neuroendocrine or amine precursor uptake and decarboxylation tumors). They produce excess endocrines such as kallikrein (an activator of bradykinin release) and serotonin. These tumors can be found in the intestine, stomach, or sometimes on the liver. In later stages, this type of cancer causes symptoms such as diarrhea, wheezing, heart murmurs, enlarged liver, and a dusky appearance to the skin. Carcinoids can be diagnosed with a urine test or with a CAT scan ...
Somatostatin levels are often elevated in diabetics, but the levels return to normal upon correction of the hormonal and metabolic deficiencies present. Elevated levels are also found in many cases of APUDomas including Vasoactive intestinal polypedtideoma, Insulinoma, Glucagonoma, and Gastrinoma. ...
DIAGNOSIS: DISSEMINATED MAST CELL TUMOUR WITH MASTOCYTAEMIA. MANAGEMENT AND FOLLOW-UP. Considering the prognosis, the current condition and possible side effects of chemotherapy, the owner elected euthanasia. Post-mortem examination was performed. Mast cells, either as discrete masses or as dense infiltrates, were present within the integument (Figure 5A), liver, jejunum, spleen (Figure 5B), presumptive mesenteric lymph node and heart.. SUMMARY. Mast cell tumour is a common neoplastic disease of cats. There are three typical forms of mast cell tumours in the cat: cutaneous, splenic/visceral and intestinal. In this case, given the presence of a systemic disease at the time of presentation it is not possible to determine the primary location of the tumour. The prognosis for a disseminated mast cell tumour is poor.. Mastocytaemia is defined as the presence of mast cells in the peripheral blood. It is a rare condition in the cat (prevalence of 0.05%) and unlike in dogs, is almost always attributed ...
Roughly one-fifth of Americans take low-dose aspirin every day for heart-healthy benefits. But based on either urine or blood tests of how aspirin blocks the stickiness of platelets - blood cells that clump together in the first stages of forming harmful clots - up to one-third of patients are deemed unlikely to benefit from daily use, or aspirin resistant.. In people who have suffered a heart attack, low-dose aspirin reduces the chances of a second event by about one-fifth, making it perhaps one of the most cost-effective drugs currently prescribed, noted study author Tilo Grosser, director of the Institute for Translational Medicine and Therapeutics. Although consumed widely by the worried well, the relative usefulness of low-dose aspirin in patients who have never had a heart attack is more controversial. According to previous primary prevention studies, low-dose aspirin reduces this groups very low risk of a first attack by about the same number of serious stomach bleeds it causes.. In the ...
SP-303, a large proanthocyanidin oligomer isolated from the latex of the plant species Croton lechleri (Eupborbiaceae) has demonstrated broad activity against a variety of DNA and RNA viruses. In cell culture, SP-303 exhibits potent activity against isolates and laboratory strains of respiratory syncytial virus (RSV), influenza A virus (FLU-A) and parainfluenza virus (PIV). Parallel assays of SP-303 and ribavirin showed comparable activity against these viruses. SP-303 also exhibits significant inhibitory activity against herpesvirus (HSV) types 1 and 2, including herpesviruses resistant to acyclovir and foscarnet. Inhibition was also observed against hepatitis A and B viruses. The antiviral mechanism of SP-303 seems to derive from its direct binding to components of the viral envelope, resulting in inhibition of viral attachment and penetration of the plasma membrane. Antiviral effects of SP-303 were measured by three distinct methods: CPE, MTT and precursor uptake/incorporation. Cytotoxicity endpoints
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Grundy RG, Wilne SH, Robinson KJ, Ironside JW, Cox T, Chong WK, Michalski A, Campbell RH, Bailey CC, Thorp N, Pizer B, Punt J, Walker DA, Ellison DW, Machin D, Childrens Cancer and Leukaemia Group (formerly UKCCSG) Brain Tumour Committee: Primary postoperative chemotherapy without radiotherapy for treatment of brain tumours other than ependymoma in children under 3 years: results of the first UKCCSG/SIOP CNS 9204 trial. Eur J Cancer; 2010 Jan;46(1):120-33 ...
Hi: I really no idea about this fatty tissue tumor other than information found online. I am a 52 yr old female and have a lipoma on my neck about the size of a golf ball. Not sure where to begin to take care of this. I have always been healthy and fortunate to stay out of the medical world. But my husband insists that I should consider having this checked out just to make sure it it is nothing else and to inquire as to the most minimal invasive process to remove (my spouse is an MRI tech). Thank you for your professional courtesy. Janet Suarez
WEDNESDAY, Feb. 17, 2021 (HealthDay News) -- One of the least understood effects of COVID-19 infection is brain fog, a kind of mental confusion that can take hold among seriously ill patients, sometimes lingering long after recovery.. Now, a new study has spotted a possible neurological clue in the form of highly unusual cell clusters in the brains of people who had COVID-19.. What were talking about is a situation where patients feel fuzzy and foggy in their thoughts, said study lead author Dr. David Nauen. Its when youre extremely tired and sluggish, and your mental activity just doesnt seem to be working as crisply and sharply as usual. And its been reported among COVID-19 patients still under care and afterwards, during the long recovery phase, he explained.. We thought it must be due to something affecting the brain, because we know other viruses can certainly affect the brain, sometimes with severe neurologic consequences, said Nauen, whos an assistant professor in the ...
References. Calabretta B, Kaczmarek LL, Selleri L, Torelli G, Ming PML, Ming SC and Mercer WE (1986) Growth-dependent expression of human Mr 53,000 tumor antigen messenger RNA in normal and neoplastic cells. Cancer. Res. 46: 5738-5742.. Deppert W, Buschhausendenker G, Patschinsky T and Steinmeyer K (1990) Cell cycle control of p53 in normal (3T3) and chemically transformed (Meth-A) mouse cells . II. requirement for cell cycle progression. Oncogene 5: 1701-1706.. Eliyahu D, Raz A, Gruss P, Givol D and Oren M (1984) Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature 312: 646-649.. Jenkins JR, Rudge K, Chumakov P and Currie GA (1985) The cellular oncogene p53 can be activated by mutagenesis. Nature 317: 816-818.. Jenkins JR, Rudge K and Currie GA (1984) Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53. Nature 312: 651-654.. Mercer WE, Avignolo C and Baserga R (1984) Role of the p53 protein in cell ...
In her first televised interview since undergoing a seven-hour surgery to remove a golf-ball-sized meningioma brain tumor in June, former E! News anchor Maria Menounos opened up to NBC News Megyn Kelly about her diagnosis and recovery.
Method and apparatus for extraction of breast tumors from three-dimensional ultrasonic images obtained by interpolation of a series of cross sectional images. The method consists of two stages are disclosed. In the first stage a membership function is automatically generated by using an output of three dimensional LoG(Laplace of Gaussian) filtering for the voxel data. In the second stage, the membership function is used for a fuzzy logic based calculation to produce three grades of the voxel attributable to three classes of
Hejazi N, Hassler W, Farghaly F: Transconjunctival microsurgical approach to the orbit: a retrospective preliminary review and analysis of experience with the first 15 operative cases. Neurosurg Quart 1999; 9: 197 208 ...
[email protected] Outside office hours please call 08448 481189. About childhood cancer Every day, 10 children ... the most out of life. For more information visit www.clicsargent.org.uk ... CLIC Sargent responds to research on Wilms Tumour diagnosis in the UK New research released .... ...
IronMatt has embarked on a new partnership with The Childrens Place to benefit the families dealing with a brain tumor diagnosis. Each time a new family enters the Family Assistance Program, the IronKid and each of his/her siblings will receive $100 gift certificate to The Childrens Place. In addition, each of the Ironkids will get a new set of Childrens Place pajamas to keep them cozy during their treatments and recovery. ...
Carcinoid Neuroendocrine tumor Small intestine neuroendocrine tumor Kulchitsky cells Apudoma Serotonin Syndrome "Carcinoid ...
Merkel cell tumor Primary cutaneous neuroendocrine carcinoma M8248/1 Apudoma M8249/3 Atypical carcinoid tumor M8250/1 Pulmonary ...
It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, ...
... cutaneous apudoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, trabecular carcinoma ...
Medullary Cells Glomus cells in Carotid Body Melanocytes of Skin Cells of Pineal Gland Renin producing cells in Kidney Apudoma ...
... apudoma MeSH C04.557.465.625.650.200 - carcinoid tumor MeSH C04.557.465.625.650.200.500 - malignant carcinoid syndrome MeSH ... apudoma MeSH C04.557.580.625.650.200 - carcinoid tumor MeSH C04.557.580.625.650.200.500 - malignant carcinoid syndrome MeSH ... apudoma MeSH C04.557.470.035.320 - cystadenoma MeSH C04.557.470.035.320.225 - cystadenoma, mucinous MeSH C04.557.470.035. ...
Cogan type Apudoma Aqueductal stenosis Aqueductal stenosis, X linked Arachindonic acid, absence of Arachnodactyly ...
In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. ... Because the label "apudoma" is very general, it is preferred to use a more specific term when possible.[citation needed] VIPoma ... 2002). "[Apudoma of Vater's ampulla: case report and review of the literature]". Il Giornale di Chirurgia (in Italian). 23 (3 ... Spence RW, Burns-Cox CJ (1975). "ACTH-secreting 'apudoma' of gallbladder". Gut. 16 (6): 473-6. doi:10.1136/gut.16.6.473. PMC ...
In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. ... Because the label "apudoma" is very general, it is preferred to use a more specific term when possible.[citation needed] VIPoma ... 2002). "[Apudoma of Vaters ampulla: case report and review of the literature]". Il Giornale di Chirurgia (in Italian). 23 (3 ... Spence RW, Burns-Cox CJ (1975). "ACTH-secreting apudoma of gallbladder". Gut. 16 (6): 473-6. doi:10.1136/gut.16.6.473. PMC ...
Carcinoid tumors may secrete hormones that can cause thickening of the lining of heart chambers, valves and blood vessels. This can lead to leaky heart valves and heart failure that may require valve-replacement surgery.. Is neuroendocrine tumor the same as carcinoid tumor?. Overview. Carcinoid tumors are a type of slow-growing cancer that can arise in several places throughout your body. Carcinoid tumors, which are one subset of tumors called neuroendocrine tumors, usually begin in the digestive tract (stomach, appendix, small intestine, colon, rectum) or in the lungs.. How rare are neuroendocrine tumors?. Neuroendocrine tumors are rare, accounting for less than one percent of all malignant disorders in the United States. It is estimated that fewer than 2,000 new cases occur in the United States each year.. ...
... On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full ... Ranked list of diseases related to "apudoma"Drugs, active principles and "apudoma"Medicinal plantsQuestions and answers from ... Apudoma. A general term collectively applied to tumors associated with the apud cells series, irrespective of their specific ...
Primary hepatic apudoma associated with serotonin syndrome was recorded in a man of 55 followed up for 6 years. Clinically, ...
... or cutaneous APUDoma (a tumor composed of cells with amine precursor uptake and decarboxylation [APUD] cytochemical properties ...
Apudoma (disorder) {253008000 , SNOMED-CT } Parent/Child (Relationship Type) Apudoma of skin (disorder) {254729005 , SNOMED-CT ...
Apudoma --analysis. en_US. dc.subject.mesh. Hormones --analysis. en_US. dc.subject.mesh. Hormones, Ectopic --analysis. en_US. ...
Apudoma ‎]] #[[Aromatic compound ‎]] #[[Ylide ‎]] #[[Zanamivir ‎]] #[[Desmin ‎]] #[[Efflux (microbiology) ‎]] #[[Elastic ...
Clinical picture of apudoma. Apudoma neoplasms originate from the so-called APUD cells (APUD) of the gastrointestinal mucosa, ... The main classification involves the division of tumors into 2 groups: orthoendocrine apudoma; paraendocrine apudoma; Those ... We list the main signs that characterize the presence in the body of such neoplasms as apudoma: redness of the skin of the face ... Like other tumors, apudoma are both malignant and benign. About 90% are localized in the gastrointestinal tract, and the ...
Director, Pulmonary Hypertension , Jose Soberon, MD , Ochnser Clinic Foundation , Ochsneer Clinic Foudnation , Ochsner , Ochsner Health System , Ochsner Health Systems , Richard Deichmann, MD , Robert Ramirez , Siobhan Trotter ...
Neural crest cells are precursors of APUDoma and neurogenic cells.. Patient with a large VIPoma. (A) Arteriogram showing ...
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Other names: Carcinoid apudoma,[1] functioning argentaffinoma,[1] Thorson-Bioerck syndrome[2]. ...
... cutaneous apudoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the ... ...
Apudoma * Chediak-Higashi syndrom * Dobbelt udløb højre ventrikel * Juvenil polymyositis * Objektivets subluxation ...
... or cutaneous APUDoma (a tumor composed of cells with amine precursor uptake and decarboxylation [APUD] cytochemical properties ...
... or cutaneous APUDoma (a tumor composed of cells with amine precursor uptake and decarboxylation [APUD] cytochemical properties ...
It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, ...
Apudoma [C04.557.465.625.650.135] * Carcinoid Tumor [C04.557.465.625.650.200] * Carcinoma, Neuroendocrine [C04.557.465.625. ...
During prenatal ultrasound, an SCT having an external component may appear as a fluid-filled cyst or a solid mass sticking out from the fetus body. Fetal SCTs that are entirely internal may be undetected if they are small; detection (or at least suspicion) is possible when the fetal bladder is seen in an abnormal position, due to the SCT pushing other organs out of place.. At birth, the usual presentation is a visible lump or mass under the skin at the top of the buttocks crease. If not visible, it can sometimes be felt; gently prodded, it feels somewhat like a hardboiled egg. A small SCT, if it is entirely inside the body, may not present for years, until it grows large enough to cause pain, constipation and other symptoms of a large mass inside the pelvis, or until it begins to extend out of the pelvis. Even a relatively large SCT may be missed, if it is internal, because the bony pelvis conceals and protects it. Mediastinal tumors, including teratomas, are similarly concealed and protected ...
Apudoma. ARDS (acute respiratory distress syndrome). Arteritis, temporal (giant cell arteritis). Arthritis. Ascites. Asthma. ...
Patients who develop this rare but aggressive skin cancer have not had a specific therapy, until todays approval of a novel immunotherapy.
A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5 ...
A 76-year-old man with a past medical history of multiple cutaneous basal cell carcinomas presents with a lesion on his right lateral lower eyelid.
Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm; distant metastases are nearly always fatal. How much do you know about MCC? Test yourself with this short quiz.
A longer follow-up and larger cohort are needed, but results from a new study showed safety and a survival benefit among patients who received nivolumab as an adjunct to surgery.
  • Since then, it has been referred to as cutaneous neuroendocrine carcinoma, small cell tumor of the skin, primary undifferentiated carcinoma of the skin, anaplastic carcinoma of the skin, murky cell carcinoma, neuroendocrine tumor of the skin, or cutaneous APUDoma (a tumor composed of cells with amine precursor uptake and decarboxylation [APUD] cytochemical properties). (medscape.com)
  • It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. (icd.codes)
  • In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. (wikipedia.org)
  • Apudoma neoplasms originate from the so-called APUD cells (APUD) of the gastrointestinal mucosa, as well as from pancreatic islet cells. (omeprazolef.com)
  • Regarding the symptoms of the disease, the main symptom of apudoma is an excess of peptides and hormones that are produced by APUD cells. (omeprazolef.com)
  • Primary hepatic apudoma with serotonin syndrome]. (semanticscholar.org)
  • Primary hepatic apudoma associated with serotonin syndrome was recorded in a man of 55 followed up for 6 years. (semanticscholar.org)
  • Because the label "apudoma" is very general, it is preferred to use a more specific term when possible. (wikipedia.org)
  • Neural crest cells are precursors of APUDoma and neurogenic cells. (medscape.com)
  • Several other names have been used to describe MCC, among these are: anaplastic carcinoma of the skin, apudoma, endocrine carcinoma of the skin, neuroendocrine carcinoma of the skin (NEC), primary small-cell carcinoma of the skin, primary undifferentiated carcinoma of the skin, and trabecular cell carcinoma. (encyclopedia.com)
  • Being an endocrine tumor, or apudoma, thyroid nodules entail the development of hyperthyroidism. (allcysts.com)
  • This skin cancer has been called by several other names, including primary small-cell carcinoma of the skin, APUDoma, primary undifferentiated carcinoma of the skin, and the Toker tumor. (medscape.com)
  • Since then, it has been referred to as cutaneous neuroendocrine carcinoma, small cell tumor of the skin, primary undifferentiated carcinoma of the skin, anaplastic carcinoma of the skin, murky cell carcinoma, neuroendocrine tumor of the skin, or cutaneous APUDoma (a tumor composed of cells with amine precursor uptake and decarboxylation [APUD] cytochemical properties). (medscape.com)
  • It is also known as cutaneous APUDoma, primary neuroendocrine carcinoma of the skin, primary small cell carcinoma of the skin, and trabecular carcinoma of the skin. (icd.codes)