Cells with the capacity to take up and decarboxylate the amine precursors DIHYDROXYPHENYLALANINE or 5-HYDROXYTRYPTOPHAN. This is a property of endocrine cells of neural and non-neural origin. APUDOMA is a general term collectively applied to tumors associated with APUD cells.

High activity of mitochondrial glycerol phosphate dehydrogenase in insulinomas and carcinoid and other tumors of the amine precursor uptake decarboxylation system. (1/22)

The activity of the mitochondrial glycerol phosphate dehydrogenase (EC 1.1.99.5), the enzyme unique to the glycerol phosphate hydrogen shuttle, was measured in normal human tissues and tumors and compared with the activity of succinate dehydrogenase, another enzyme that transfers electrons to ubiquinone at site II of the electron transport chain. Six of 7 insulinomas and 10 of 12 carcinoid tumors showed high glycerol phosphate dehydrogenase activity. The activity was also increased in 3 of 4 gastrinomas, 2 paraganglionomas, 1 of 4 thyroid nodules, and 1 parathyroid tumor. These tissues belong to the amine precursor uptake decarboxylation system. The activity of glycerol phosphate dehydrogenase was generally unremarkable in non-amine precursor uptake decarboxylation system tumors and in normal tissues studied. However, 1 of 2 breast carcinomas, 1 submandibular tumor, and 2 of 3 melanomas were enriched in glycerol phosphate dehydrogenase activity. In general, succinate dehydrogenase activity exceeded that of glycerol phosphate dehydrogenase in all tissues except some of the tissues in which glycerol phosphate dehydrogenase activity was high. Normal tissues, such as the pancreatic beta-cell, which aerobically metabolize glucose rapidly utilize the glycerol phosphate shuttle to oxidize the large amount of NADH formed from glucose metabolism in the cytosol. Whether this is the reason for the enriched activity of the glycerol phosphate dehydrogenase in certain amine precursor uptake decarboxylation system tumors is unknown.  (+info)

A survey of endocrine cells in the pancreas of the echidna (Tachyglossus aculeatus) with special reference to pancreatic motilin cells. (2/22)

Pancreatic endocrine cells were examined in a primitive egg-laying mammal, the echidna, using immunohistochemistry. Immunoreactive endocrine cells were observed using antisera to insulin, glucagon, somatostatin, avian pancreatic polypeptide and bovine pancreatic polypeptide. In addition, motilin-immunoreactive cells were identified in both the endocrine and exocrine pancreas of pouch-young and adult echidnas using three types of motilin antisera. Since the motilin-immunoreactive cells did not cross-react with any other pancreatic hormones tested, they are identified as an independent endocrine cell type.  (+info)

Production of calcitonin, adrenocorticotropic hormone, and beta-melanocyte-stimulating hormone in tumors derived from amine precursor uptake and decarboxylation cells. (3/22)

The tumor production of human calcitonin (CT) was examined by radioimmunoassay, and it was found that 50 of 85 (59%) tumor tissues collected at random contained immunoreactive CT. These tumors were grouped as to whether they were derived from the amine precursor uptake and decarboxylation (APUD) series. The group that was derived from APUD cells showed appreciable amounts of CT in 30 of 31 (97%) of these tumors or in 20 of 21 (95%) when the medullary carcinomas of the thyroid were excluded. However, of the non-APUD group of tumors only 20 of 54 (37%) were found to contain CT, so that the difference between these two groups was highly significant (p less than 0.001). Of the tumors with ectopic adrenocorticotropic hormone-melanocyte-stimulating hormone production, 12 of 14 were shown to contain CT. These data indicate that CT is a common product of the APUD tumors and that tumor production of CT is often associated with that of adrenocorticotropic hormone and beta-melanocyte-stimulating hormone.  (+info)

Sequential morphologic alterations in the bronchial epithelium of Syrian golden hamsters during N-nitrosomorpholine-induced pulmonary tumorigenesis. (4/22)

N-nitrosomorpholine (NM)-induced pulmonary carcinogenesis was examined by light and electron microscopy in a 20-week serial sacrifice study using Syrian golden hamsters. First to be observed were a proliferation of endocrine APUD cells and a formation of lamellated inclusion bodies in the cytoplasm of Clara cells. After continued NM treatment, APUD cells underwent squamous metaplasia and Clara cells invaded the pulmonary tissues adjacent to the bronchi. Lung tumors consisted of cells possessing numerous lamellated inclusion bodies in their cytoplasm and a few squamous metaplastic and APUD cells. The observed pathologic alterations closely resembled those found after treatment with N-diethylnitrosamine (DEN) and N-dibutylnitrosamine (DBN) but were completely different from the cellular reactions induced by polycyclic aromatic hydrocarbons. It is concluded that the observed alterations of APUD cells and Clara cells are specific to nitrosamines.  (+info)

Quantitative characteristics of the Feyrter (APUD) cells of the neonatal rabbit lung in normoxia and chronic hypoxia. (5/22)

Our studies show that the apparent number of Feyrter cells in the lung declines during the neonatal period in normoxic rabbits, and that in hypoxic animals a uniformly and significantly lower number of cells occurs as compared with the normoxic rabbits. There is some indication of degranulation of cells in the hypoxic groups. It is suggested that environmental and/or physiological factors associated with the start of extrauterine life, or lung development, may affect the apparent number and probable level of activity of these cells. These changes seem to be enhanced by hypoxia. Mast cells are scarce, and Feyrter cells are relatively more numerous along the airways. These cell types could possibly represent storage sites for 5-hydroxytryptamine, as suggested also by other investigators. Intraepithelial nerve fibres in bronchi and bronchioles were found but they were not limited to innervations of Feyrter cells or related cell bodies.  (+info)

Endocrine-like cells in the terminal bronchioles and saccules of human fetal lung: an ultrastructural study. (6/22)

An ultrastructural study of Kulschitsky cells was made on lung tissue from five human fetuses of gestational ages between 18 and 25 weeks. The cells were found to occur with relative frequency throughout the bronchi and bronchioles, as well as in the developing saccules. This report describes in detail the cells of the terminal bronchioles and saccules, where their long cytoplasmic processes weave through the epithelium and come into contact with intercellular spaces and the lumen. The cytoplasmic organelles have an orderly arrangement comparable to secreting cells. Dense core vesicles characterise the cytoplasm but clear vesicles and some with less dense, diffuse cores are also present, and may be seen outside the plasma membrane and in the interstitial spaces. The K-cells are usually colsely associated with capillaries or smooth muscle cells across the basement membrane. In addition, the rare occurrence of a small unmyelinated nerve fibre in the vicinity of a K-cell in a terminal bronchiole raises the possibility that the cells fulfill a type of 'mini receptor' role in addition to their probable vasoactive one. Evidence is given that K-cells divide in human fetal lung.  (+info)

Neuroendocrine differentiation antigen on human lung carcinoma and Kulchitski cells. (7/22)

In the normal lung, a subset of cells with a histological appearance consistent with that of Kulchitski cells are the only lung cells reacting with a monoclonal antibody (MOC-1) raised against a human small cell lung carcinoma-derived cell line. Outside the lung, a subset of normal endocrine cells (in the adrenal, thyroid, ovary, and pancreas) as well as neural cells (brain and peripheral Schwann cells) also express the antigen detected by MOC-1 (named MOC-1-related antigen). Some of these positively reacting cells are ectodermally derived, whereas others are of proven endodermal origin, indicating that the MOC-1-related antigen is not a cell lineage-specific antigen. Instead, the common expression of the antigen by cells with a neural, endocrine, or neuroendocrine function suggests that the antigen related to a neuroendocrine differentiation state of these cells. The presence of the MOC-1-related antigen on several non-lung tumors mostly paralleled its normal tissue distribution, indicating that the antigen is generally retained upon malignant transformation. In lung carcinoma, the antigen proves to be present on almost all small cell carcinomas tested. In addition, adenocarcinoma and mixed adenosquamous carcinoma could also express the antigen, whereas pure squamous cell carcinoma generally did not. This finding will be discussed in relation to a proposed "common stem cell" histogenesis of lung carcinoma.  (+info)

Pulmonary endocrine cells immunoreactive for calcitonin in the lungs of fetal and neonatal rats. (8/22)

Previous studies have shown that the size of the population of bronchopulmonary endocrine (Feyrter) cells appears to be greatest in fetal and neonatal life. This has led to the logical assumption that these cells are important during this period and undergo a subsequent decline in number thereafter. In this study endocrine cells containing calcitonin or a closely related cross reacting peptide have been demonstrated in the lungs of fetal and neonatal rats by immunoenzyme histochemistry. They appear first about three days before birth and their number, expressed as immunoreactive cells per cm2 of histological section, remains relatively constant for up to three weeks after birth. It has been shown previously in this department that endocrine cells immunoreactive for calcitonin are present in the lungs of the normal adult rat. Their number in these adult animals is closely similar to the numbers of cells in the lungs of the developing animals of the present study. It is suggested that, at least in the rat, bronchopulmonary endocrine cells immunoreactive for calcitonin have a role that is not confined merely to the period of transition from fetal to neonatal life.  (+info)

APUD cells are a type of neuroendocrine cell that originated from the neural crest and are widely distributed throughout the body. The term "APUD" is an acronym for "Amine Precursor Uptake and Decarboxylation," which describes the ability of these cells to take up and decarboxylate amino acid precursors to produce biologically active amines, such as serotonin, histamine, and catecholamines.

APUD cells are capable of synthesizing, storing, and releasing hormones or neurotransmitters in response to various stimuli. They can be found in several endocrine and neural tissues, including the thyroid gland, adrenal medulla, pituitary gland, pancreas, lungs, and gastrointestinal tract.

In the gastrointestinal tract, APUD cells are often referred to as enterochromaffin cells or Kulchitsky cells. They play a crucial role in regulating gut motility, secretion, and blood flow through the release of hormones such as serotonin, gastrin, and somatostatin.

It's worth noting that the APUD cell concept has been largely replaced by the more comprehensive neuroendocrine system concept, which encompasses a broader range of cells with neurosecretory functions.

APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. ... Cells of Pineal Gland Renin producing cells in the kidney Apudoma Enteroendocrine cell Neuroendocrine cell List of human cell ... who developed the APUD concept in the 1960s based on calcitonin-secreting parafollicular C cells of dog thyroid. These cells ... APUD+Cells at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description, ...
Sidhu GS (July 1979). "The endodermal origin of digestive and respiratory tract APUD cells. Histopathologic evidence and a ... Giant cells in a lung cancer are highly associated with the presence of spindle cells. The chromatin of malignant giant cells ... Both "tumor cell-tumor cell" and "leukocyte-tumor cell" emperipolesis (i.e. active penetration of the latter by the former) is ... The cells from giant-cell carcinomas are anaplastic, and show no evidence of cell maturation or differentiation, lacking the ...
... cells therefore belong to the group of APUD (amine precursor uptake and decarboxylation) cells. These cells are ... Chromophobe cell Melanotroph Acidophil cell Basophil cell Oxyphil cell Oxyphil cell (parathyroid) Pituitary gland ... A chromophil biological cell is a cell which is easily stainable by absorbing chromium salts used in histology to increase the ... Chromophil cells are mostly hormone-producing cells containing so-called chromaffin granules. In these subcellular structures, ...
APUD cells are considered part of the neuroendocrine system, and share many staining properties with neuroendocrine cells. ... Neuroendocrinology Neurohormone Chromophobe cell Melanotroph Chromophil Acidophil cell Basophil cell Oxyphil cell Oxyphil cell ... Pulmonary neuroendocrine cells are also known as Kulchitsky cells or K cells. They are located in the respiratory epithelium of ... Neuroendocrine cells are cells that receive neuronal input (through neurotransmitters released by nerve cells or neurosecretory ...
... the short-chain fatty acid receptor GPR43 is expressed both by this cell type and by mast cells of the mucosa. APUD cells ... Enterochromaffin-like cells or ECL cells are a type of neuroendocrine cell secreting histamine. Located in a increasing manner ... Enterochromaffin-like cells are enteroendocrine and neuroendocrine cells also known for their similarity to chromaffin cells ... Enterochromaffin cells are enteroendocrine and neuroendocrine cells with a close similarity to adrenomedullary chromaffin cells ...
It is thought to originate from neuroendocrine cells (APUD cells) in the bronchus called Feyrter cells (named for Friedrich ... Small-cell carcinoma is an undifferentiated neoplasm composed of primitive-appearing cells. As the name implies, the cells in ... Treatment is similar to small cell lung cancer, but survival rates are much higher than other small-cell carcinomas. Small-cell ... small cell lung cancer 14.9%; and for "Distant" small cell lung cancer 2.9%. Women affected by small-cell lung cancer have ...
Alejandro Apud, Uruguayan football manager Antonio Apud, Argentine footballer apud, an expression of Latin origin APUD cells, a ... group of endocrine cells This disambiguation page lists articles associated with the title Apud. If an internal link led you ...
APUD) cells in the avian carotid body, using a cytochemical marker system". Histochemie. 34 (3): 191-203. doi:10.1007/ ... Glomus cells are the cell type mainly located in the carotid bodies and aortic bodies. Glomus type I cells are peripheral ... Glomus type II cells are sustentacular cells having a similar supportive function to glial cells. The signalling within the ... Glomus type II cells are not innervated. Glomus type I cells are embryonically derived from the neural crest. In the carotid ...
In pathology, an apudoma is an endocrine tumour that arises from an APUD cell from structures such as the ampulla of Vater. ... They were historically thought to be derived from neural crest cells, but this has since been shown to be untrue (see ... 2000). "Superficial undifferentiated small cell carcinoma of the esophagus showing an interesting growing pattern in histology ...
... collectively known as diffuse neuroendocrine system or APUD cells. Neuroendocrine cells are present in all regions of the human ... Prostatic neuroendocrine cells, also known as endocrine-paracrine cells, are part of a larger regulatory cell population ... The open type cells may in addition receive regulatory signals from luminal molecules The developmental origin of these cells ... Neuroendocrine tumor cells express cytokeratins that are typically expressed by luminal secretory type cells, but lack basal ...
Cholecystokinin, a hormone secreted by the APUD cells located in the proximal mucosa of the small intestine is administered ...
Merkel cells are sometimes considered APUD cells (an older definition, more commonly classified as a part of dispersed ... Merkel cells, also known as Merkel-Ranvier cells or tactile epithelial cells, are oval-shaped mechanoreceptors essential for ... Merkel cells are found in the skin and some parts of the mucosa of all vertebrates. In mammalian skin, they are clear cells ... Merkel Cells at the U.S. National Library of Medicine Medical Subject Headings (MeSH) NIF Search - Merckel Disc Cell via the ...
The pars distalis contains two types of cells, including chromophobe cells and chromophil cells. The chromophils can be further ... Racagni, G; Apud, J.A; Cocchi, D; Locatelli, V; Muller, E.E. (1982) GABAergic control of anterior pituitary hormone secretion. ... divided into acidophils (alpha cells) and basophils (beta cells). These cells all together produce hormones of the anterior ... It also contains non-endocrine folliculostellate cells which are thought to stimulate and support the endocrine cell ...
4. Erlangen, Germany: Apud J.J. Palmium. p. 78. Paulet, Jean-Jacques (1793). Traité des champignons (in French). Paris: Impr. ... of dry matter in mushroom cell walls. Chitin, hemicellulose, and pectin-like carbohydrates-all indigestible by humans- ...
apud Mont. development on the cork-oak, Quercus suber L., in Morocco. Cryptogamic Mycology 21: 235-248. Franceschini, A., Corda ... The asexual spores (conidia) occur in pycnidia from conidiogenous cells, without conidiophores. Pycnidia are dark brown to ...
Cell. 176 (1-2): 295-305.e10. doi:10.1016/j.cell.2018.11.005. PMID 30528431. Rasmussen S, Allentoft ME, Nielsen K, Orlando L, ... apud Jacobum Bohn. LCCN 08014593. OL 6996785M. Archived from the original on 3 August 2008 - via Internet Archive. Wheelis 2002 ... doi:10.1016/j.cell.2015.10.009. PMC 4644222. PMID 26496604. Roosen J, Curtis DR (2018). "Dangers of Noncritical Use of ... October 2015). "Early divergent strains of Yersinia pestis in Eurasia 5,000 years ago". Cell. 163 (3): 571-582. ...
The basidia (spore-bearing cells) are club-shaped with a narrow base, and have dimensions of 20-30 by 7-9 µm. Like other ... 1801). Synopsis Methodica Fungorum (in Latin). Gottingen, Sweden: Apud H. Dieterich. p. 523. De AB. (1997). "Taxonomy of ...
Antverpiæ: apud heredes Martini Nutii et Ioannem Meursium. Campion, Edmund. A Historie of Ireland, written in the yeare 1571., ... "Little-ease is a cell where the prisoner cannot stand or lie at length." Guiney (1908), p.139 Simpson (1867), p.277 Simpson ( ... Imprisoned for four days in the Tower of London in a tiny cell called "Little Ease", Campion was then taken out and questioned ...
Apud Wilhelmum Ianssonium. OCLC 34709352. Archived from the original on 2023-07-02. Retrieved 2023-03-12. Josef Maria Eder ( ... first known publicly shared picture via a cell phone, by Philippe Kahn. 2000 - J-SH04 introduced by J-Phone, the first ...
In fuel cells, electro-osmosis causes protons moving through a proton exchange membrane (PEM) to drag water molecules from one ... Apud Universitatem Literarum Caesaream Mosquensem Institutae (Memoirs of the Physical-Medical Society, Instituted at the Moscow ... Companion cells are involved in the "cyclic" withdrawal of ions (K+) from sieve tubes, and their secretion parallel to their ... The hydrogen peroxide and/or pH changes generated can adversely affect biological cells and biomolecules such as proteins, ...
1. Paris: Apud A. Belin. Maas, Paul J. M.; de Kamer, Hiltje Maas-van; Junikka, Leo; de Mello-Silva, Renato; Rainer, Heimo (2001 ... "Flavonoids from Annona dioica leaves and their effects in Ehrlich carcinoma cells, DNA-topoisomerase I and II". Journal of the ...
Evidence suggests that the mechanism for this detoxification involves the cadmium binding to the fungal cell walls, as well as ... Batsch, August (1786). Elenchus Fungorum (Discussion of Fungi), Continuatio Prima (in Latin). Halle, Magdeburg, Germany: Apud ... An antigen in the mushroom triggers the immune system to attack red blood cells. Serious and commonly fatal complications ... The use of corticosteroids may be a useful adjunct in treatment, as they protect blood cells against hemolysis, thereby ...
The spore-bearing cells, the basidia, are club-shaped and have dimensions of 24-33 by 6-7.5 µm; they are colorless, and each ... 4. Regensburg: Apud J.J. Palmium. p. 40; plate 94. Fries EM. (1836). Anteckningar öfver de i Sverige växande ätliga svampar (in ... Microscopically, the terminal cells in the cap cuticle of R. parvovirescens are more swollen than those of R. virescens, which ... Like other mushrooms in the Russulales, the flesh is brittle, owing to the sphaerocyst cytoarchitecture-cylindrical cells that ...
Due to a lack of money not all Colgan's writings could be published, and a catalogue of manuscripts found in his cell after his ... Acta Sanctorvm Veteris Et Maioris Scotiae, Sev Hiberniae Sanctorvm Insvlae, Volume 2. Publisher: Apud Cornelivm Coenestenivm, ...
apud viduam Herissant, typographum, viâ novâ B. M. sub signo Crucis aureæ. de Candolle; A. P.; et al. (1824-1873). Prodromus ... resulting in unprecedented accumulation of DNA sequence data from various genes present in compartments of plant cells. In 1998 ...
... and bone marrow cells from mice. The extract also stimulated mouse cells associated with the immune system; specifically, it ... 1801). Synopsis Methodica Fungorum (in Latin). Göttingen, Germany: Apud Henricum Dieterich. p. 135. Morgan AP (1889). "North ... Extracts from A. hygrometricus containing the polysaccharide named AE2 were found to inhibit the growth of several tumor cell ... Mallick SK, Maiti S, Bhutia SK, Maiti TK (2011). "Activation of RAW 264.7 cells by Astraeus hygrometricus-derived heteroglucan ...
Göttingen: Apud H. Dieterich. p. 246. Retrieved 2010-10-12. Nees von Esenbeck CDG. (1817). System der Pilze und Schwämme (in ... The basidia (spore-bearing cells) are cylindrical, with dimensions of 20-25 by 3-4 µm. They have eight sterigmata (slender ...
doi:10.1016/j.cell.2020.03.020. PMID 32243793. S2CID 214753833. Johnson, M. W.; Richards, W. A.; Griffiths, R. R. (2008). " ... Ismael Eduardo Apud Peláez. (2020). Ayahuasca: Between Cognition and Culture. Publicacions Universitat Rovira i Virgili. ISBN ... Nutt, David; Erritzoe, David; Carhart-Harris, Robin (2020). "Psychedelic Psychiatry's Brave New World". Cell. 181 (1): 24-28. ... Cell Reports. 23 (11): 3170-3182. doi:10.1016/j.celrep.2018.05.022. PMC 6082376. PMID 29898390. de Vos, Cato M. H.; Mason, ...
Ulisse Aldrovandi (1600). Ornithologiae Tomus Alter (in Latin). Bononiae: Apud Io. Bapt. Bellagambam [Giovanni Battista ... Cell biology stubs, Poultry stubs). ...
The gill flesh is made of greatly enlarged cells, and stains pale vinaceous (red wine color) in iodine. The flesh of the cap ... 1801). Synopsis Methodica Fungorum (in Latin). Göttingen: Apud H. Dieterich. p. 390. Retrieved 2010-09-25. Fries EM (1821). ... The basidia (spore-bearing cells) are four-spored, rarely two-spored. The pleurocystidia (cystidia on the gill face) are not ... The tissue beneath the pellicle is made entirely of greatly enlarged cells, which appear pale vinaceous in iodine stain. The ...
APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. ... Cells of Pineal Gland Renin producing cells in the kidney Apudoma Enteroendocrine cell Neuroendocrine cell List of human cell ... who developed the APUD concept in the 1960s based on calcitonin-secreting parafollicular C cells of dog thyroid. These cells ... APUD+Cells at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short description, ...
"APUD Cells" by people in this website by year, and whether "APUD Cells" was a major or minor topic of these publications. ... "APUD Cells" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "APUD Cells" by people in Profiles. ... APUDOMA is a general term collectively applied to tumors associated with APUD cells. ...
Current methods for studying the functional morphology of apud cells]. Iuzhakov VV, Raĭkhlin NT, Kvetnoĭ IM, Iakovleva ND, ... Peptidergic innervation and the APUD system in normal conditions and in various pathological states]. Kvetnoĭ IM, Iakovleva ND. ...
The cells in pancreatic endocrine neoplasms are termed amine precursor uptake and decarboxylation (APUD) cells because they ... 15] Instead, the tumors arise from APUD stem cells, which are pluripotential neuroendocrine cells located within the ductular ... APUD cells were once believed to originate from the embryologic neural crest, but current evidence suggests that these cells- ... The origin of gut and pancreatic neuroendocrine (APUD) cells--the last word?. J Pathol. 1998 Oct. 186(2):117-8. [QxMD MEDLINE ...
The degree of integration of the goblet cells versus APUD cells varies from pure GCC to pure carcinoid tumor. GCC cells have ... Goblet cell carcinoma in males. Right hemicolectomy. Goblet cell carcinoma in females (regardless of age). Right hemicolectomy ... Ovarian metastases of appendiceal tumors with goblet cell carcinoidlike and signet ring cell patterns: a report of 30 cases. Am ... GCC is derived from undifferentiated stem cells which are completely different from the endocrine cells in the mucosal stroma. ...
Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of ... Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or ... The Identification of CELSR3 and Other Potential Cell Surface Targets in Neuroendocrine Prostate Cancer. Cancer Res Commun. ...
Islet cells commonly are referred to as APUD cells, a name derived from their high amine content and capacity for amine ... Pancreatic islet cells are part of the diffuse neuroendocrine system of the gut and pancreatic endocrine system. ... Islet cells commonly are referred to as APUD cells, a name derived from their high amine content and capacity for amine ... Although nonfunctional islet cell tumors are not uncommon at autopsy, most islet cell tumors with clinical manifestations are ...
1) AD, 100% penetrance (derived from APUD cells=amine precursor uptake and decarboxylation)2) Parathyroid hyperplasia (1st to ... unable to differentiate between follicular cell adenoma, follicular cell hyperplasia and follicular cell CA on FNA.3) solid, ... ie-small cell lung CA)3) NP-59 scintography4) #1 Pituitary adenoma (80%), #2 Ectopic ACTH (ie-small cell lung CA), #3 adrenal ... Pheochromocytoma1) cell type2) where do they arise from3) what is the 10% rule4) what syndromes are they associated with5) what ...
Intestinal Secretin Cells L Cells (Intestine) S Cells (Intestine) Secretin Cells of Gut Previous Indexing. APUD Cells (1977- ... APUD Cells. Public MeSH Note. 2006; see ENDOCRINE CELLS OF GUT 1998-2005. History Note. 2006 (1998). Date Established. 1998/01/ ... Endocrine Cells of Gut Endocrine Cells, Gastrointestinal Intestinal L Cells ... Intestinal L Cells Narrower Concept UI. M0029479. Scope Note. Intestinal L cells are located in the MUCOSA of distal ILEUM and ...
The diffuse neuroendocrine system and the apud concept: related "endocrine" peptides in brain, intestine, pituitary, placenta, ... Amine storage and function in peptide hormone-producing cells.. Sundler F, Hakanson R, Loren I, Lundquist I., Invest Cell ... Dopamine-containing cells belong to the class of closed and open type endocrine cells and were found in the fundic area and in ... The endocrine cells of the digestive system: amines, peptides, and modes of action.. Grube D., Anat. Embryol. 175(2), 1986 PMID ...
APUD Cells (1977-1997). Endocrine Glands (1973-1997). Public MeSH Note:. 2006; see ENDOCRINE CELLS OF GUT 1998-2005. ... Intestinal L Cells Entry term(s). Intestinal L Cell L Cell (Intestine) L Cell, Intestinal L Cells (Intestine) L Cells, ... Gut Secretin Cell Gut Secretin Cells Intestinal Secretin Cell S Cell (Intestine) S Cells (Intestine) Secretin Cell, Intestinal ... L Cell (Intestine). L Cell, Intestinal. L Cells (Intestine). L Cells, Intestinal. S Cell (Intestine). S Cells (Intestine). ...
C cells produce calcitonin and come from the neural crest. Carcinoma can cause the so-called APUD syndrome. It appears in the ... Hürhle cell tumors. Tumors of this type are formed of layers of cells with eosinophilic cytoplasm; Some are obviously malignant ... Clusters of cells separated by area of collagen and amyloid are observed; They can be polyhedral and simulate carcinoid or ... Calcitonin is produced by C cells and does not appear to have physiological intervention. Its therapeutic use is limited to the ...
Tumor of serotonin producing cells in GIT → APUD (Amine Precursor Uptake Decarboxylase) Cells ... Rare catecholamine-secreting tumor derived from chromaffin cells.. *- Tumors arise outside the adrenal gland are termed extra- ... Slow-growing but often malignant type of neuroendocrine tumor, originating in cells of neuroendocrine system ...
Abraham L. Kierszenbaum (2002). Histology and cell biology: an introduction to pathology. St. Louis: Mosby. ISBN 0-323-01639-1. ...
Paget J: Apud McCARTHY E: Giant-cell tumor of mammary: a historical perspective. Histopathology 1854,153(1980):14-25. ... A: Solid adenocarcinoma; The presence of neoplastic, mitotic and inflammatory cells (H&E, X 200.), B: Cartilage tissue cells ... F and G: This cluster of cells shows multinucleated cells containing several irregularly sized nucleiare found in some cases, ... D: Cytological appearance of spindle shape cells, May-Grunwald-Giemsa staining method, 400X. E: Myoepithelial cells (spindle ...
Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of ... Neuroendocrine cells -- See Paraneurons 1 Neuroendocrine Cells -- physiology : Neurophysiology of neuroendocrine neurons / ... Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or ...
Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of ... Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or ...
Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of ... In the thyroid gland, oxyphil cells are known as Hurthle cells and Askanazy cells.. ... Neoplasms, Germ Cell and Embryonal. Neoplasms composed of primordial GERM CELLS of embryonic GONADS or of elements of the germ ... Carcinoma, Renal Cell. A heterogeneous group of sporadic or hereditary carcinoma derived from cells of the KIDNEYS. There are ...
Merkel cell carcinoma (MCC) is an uncommon and aggressive cutaneous neoplasm that lacks distinguishing clinical features. ... Merkel cell carcinoma (MCC) is the eponym for primary cutaneous neuroendocrine carcinoma, a dermal neoplasm with cytoplasmic, ... APUD) cell marker. Studies have also shown staining for cytokeratins 8, 18, and 19. ... squamous cell carcinoma, basal cell carcinoma, solar keratoses, or lentigo maligna. Merkel cell carcinoma (MCC) has also been ...
... cell-mediated immunodeficiency condition [apud 43], and was widely employed until 1999. ... Aa is a Gram-negative microorganism that have Lipopolysaccharide (LPS) in cell wall, this LPS induce a significant macrophage ... birth defects in neutrophils can cause injury in the chemotaxis of polymorphonuclear cells 19. There is heterogeneity within ... stimulating growth and chemotaxis of fibroblasts and at the same time preventing the migration of epithelial cells by ...
APUD Cells A11.382.944.500 Aquabirnavirus B4.909.777.123.50 Aquatic Organisms G16.500.275.810.650.75 G16.500.275.725.500.650.75 ... B-Cell Activating Factor D12.644.276.972.61 D12.776.467.972.61 D23.529.972.61 B-Cell-Specific Activator Protein D12.776.930.626 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Cell Culture Techniques E5.200.500.223 E5.200.500.265 Cell-Derived Microparticles A11.284.149.165.82 A11.284.295.588.500 ...
APUD Cells A11.382.944.500 Aquabirnavirus B4.909.777.123.50 Aquatic Organisms G16.500.275.810.650.75 G16.500.275.725.500.650.75 ... B-Cell Activating Factor D12.644.276.972.61 D12.776.467.972.61 D23.529.972.61 B-Cell-Specific Activator Protein D12.776.930.626 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Cell Culture Techniques E5.200.500.223 E5.200.500.265 Cell-Derived Microparticles A11.284.149.165.82 A11.284.295.588.500 ...
APUD] and neuroendocrine cell system). ... Update on Large Cell Neuroendocrine Carcinoma * New Tool in ... In 1914, Gosset and Masson demonstrated that carcinoid tumors might arise from enterochromaffin cells (Kulchitsky cell) within ... 1, 2, 3] Carcinoid tumors are of neuroendocrine origin and derive from primitive stem cells, which can give rise to multiple ... Generally, the tumor cells contain glucagon and glicentin-related peptides rather than serotonin. The 5-year survival rate is ...
APUD Cells A11.382.944.500 Aquabirnavirus B4.909.777.123.50 Aquatic Organisms G16.500.275.810.650.75 G16.500.275.725.500.650.75 ... B-Cell Activating Factor D12.644.276.972.61 D12.776.467.972.61 D23.529.972.61 B-Cell-Specific Activator Protein D12.776.930.626 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Cell Culture Techniques E5.200.500.223 E5.200.500.265 Cell-Derived Microparticles A11.284.149.165.82 A11.284.295.588.500 ...
APUD Cells A11.382.944.500 Aquabirnavirus B4.909.777.123.50 Aquatic Organisms G16.500.275.810.650.75 G16.500.275.725.500.650.75 ... B-Cell Activating Factor D12.644.276.972.61 D12.776.467.972.61 D23.529.972.61 B-Cell-Specific Activator Protein D12.776.930.626 ... Embryonal Carcinoma Stem Cells A11.872.190.500 A11.872.700.250.500 Embryonic Stem Cells A11.872.190 A11.872.700.250 Emergency ... Cell Culture Techniques E5.200.500.223 E5.200.500.265 Cell-Derived Microparticles A11.284.149.165.82 A11.284.295.588.500 ...
87012603). RIN-5F cells secrete insulin, produce high levels of the key APUD enzyme, L-dopa-decarboxylase and contain membrane- ... Cell Line Data Base: structure and recent improvements towards molecular authentication of human cell lines.. Nucleic Acids ... you will go to the list of corresponding cell lines (e.g., retionoblastoma cell lines).. RIN-5F (rat, islet tumor). SPECIES: ... Home - Cell Index - Search - Web Sites Species - Tissues - Tumors - Pathologies - Tr. Agents Collections - Laboratories - ...
There have been at each cell of the special metallic inclusions in each APUD locus - a large nano-object with spikes, like a ... cytes with supporting cells. These cells must be able to give guidance - a goal. Ue Ooi that are well trained. We also know how ... It may well be that under the membrane walls of these vesicles and granules as well as in our cells have evolved and moved very ... At the heart of it - the same peptide-nucleic nano-tehnolgiya that in the cells of our organisms. I realized it when sitting in ...
In the 32d of King Ed[ward] III [1327] Nic Wadelyns, an Hermit, had the Custody of it ; who had a little Cabbin or Cell in the ... They were commonly called Heremitae apud Petty Pont. 1444: W. Wicham, in his Will, left 6s. 8d. for the repair of the bridge. ...
Key factors in the regulation of fetal and postnatal Leydig cell development. J Cell Physiol. 2007 Nov; 213(2):429-33. ... Steroid-producing cells in the interstitial tissue of the TESTIS. They are under the regulation of PITUITARY HORMONES; ... "Leydig Cells" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Leydig Cells" by people in this website by year, and whether " ...

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