Apoptosis Inducing Factor: A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.Bepridil: A long-acting calcium-blocking agent with significant anti-anginal activity. The drug produces significant coronary vasodilation and modest peripheral effects. It has antihypertensive and selective anti-arrhythmia activities and acts as a calmodulin antagonist.Indoleamine-Pyrrole 2,3,-Dioxygenase: A dioxygenase with specificity for the oxidation of the indoleamine ring of TRYPTOPHAN. It is an extrahepatic enzyme that plays a role in metabolism as the first and rate limiting enzyme in the kynurenine pathway of TRYPTOPHAN catabolism.Anti-Arrhythmia Agents: Agents used for the treatment or prevention of cardiac arrhythmias. They may affect the polarization-repolarization phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibers. Anti-arrhythmia agents are often classed into four main groups according to their mechanism of action: sodium channel blockade, beta-adrenergic blockade, repolarization prolongation, or calcium channel blockade.Biperiden: A muscarinic antagonist that has effects in both the central and peripheral nervous systems. It has been used in the treatment of arteriosclerotic, idiopathic, and postencephalitic parkinsonism. It has also been used to alleviate extrapyramidal symptoms induced by phenothiazine derivatives and reserpine.Phenothiazines: Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.Administration, Rectal: The insertion of drugs into the rectum, usually for confused or incompetent patients, like children, infants, and the very old or comatose.Prescription Drug Misuse: Improper use of drugs or medications outside the intended purpose, scope, or guidelines for use. This is in contrast to MEDICATION ADHERENCE, and distinguished from DRUG ABUSE, which is a deliberate or willful action.Suppositories: Medicated dosage forms that are designed to be inserted into the rectal, vaginal, or urethral orifice of the body for absorption. Generally, the active ingredients are packaged in dosage forms containing fatty bases such as cocoa butter, hydrogenated oil, or glycerogelatin that are solid at room temperature but melt or dissolve at body temperature.Protective Devices: Devices designed to provide personal protection against injury to individuals exposed to hazards in industry, sports, aviation, or daily activities.Tranquilizing Agents: A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Facial Muscles: Muscles of facial expression or mimetic muscles that include the numerous muscles supplied by the facial nerve that are attached to and move the skin of the face. (From Stedman, 25th ed)Diplopia: A visual symptom in which a single object is perceived by the visual cortex as two objects rather than one. Disorders associated with this condition include REFRACTIVE ERRORS; STRABISMUS; OCULOMOTOR NERVE DISEASES; TROCHLEAR NERVE DISEASES; ABDUCENS NERVE DISEASES; and diseases of the BRAIN STEM and OCCIPITAL LOBE.Migraine Disorders: A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)Tryptamines: Decarboxylated monoamine derivatives of TRYPTOPHAN.Chest Pain: Pressure, burning, or numbness in the chest.Jaw: Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.Universal Precautions: Prudent standard preventive measures to be taken by professional and other health personnel in contact with persons afflicted with a communicable disease, to avoid contracting the disease by contagion or infection. Precautions are especially applicable in the diagnosis and care of AIDS patients.Physician-Patient Relations: The interactions between physician and patient.Phenethylamines: A group of compounds that are derivatives of beta- aminoethylbenzene which is structurally and pharmacologically related to amphetamine. (From Merck Index, 11th ed)United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Phytotherapy: Use of plants or herbs to treat diseases or to alleviate pain.Drugs, Chinese Herbal: Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.United StatesIsocarboxazid: An MAO inhibitor that is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in the treatment of panic disorder and the phobic disorders. (From AMA, Drug Evaluations Annual, 1994, p311)Desipramine: A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.Monoamine Oxidase Inhibitors: A chemically heterogeneous group of drugs that have in common the ability to block oxidative deamination of naturally occurring monoamines. (From Gilman, et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed, p414)Tranylcypromine: A propylamine formed from the cyclization of the side chain of amphetamine. This monoamine oxidase inhibitor is effective in the treatment of major depression, dysthymic disorder, and atypical depression. It also is useful in panic and phobic disorders. (From AMA Drug Evaluations Annual, 1994, p311)Selegiline: A selective, irreversible inhibitor of Type B monoamine oxidase. It is used in newly diagnosed patients with Parkinson's disease. It may slow progression of the clinical disease and delay the requirement for levodopa therapy. It also may be given with levodopa upon onset of disability. (From AMA Drug Evaluations Annual, 1994, p385) The compound without isomeric designation is Deprenyl.Monoamine Oxidase: An enzyme that catalyzes the oxidative deamination of naturally occurring monoamines. It is a flavin-containing enzyme that is localized in mitochondrial membranes, whether in nerve terminals, the liver, or other organs. Monoamine oxidase is important in regulating the metabolic degradation of catecholamines and serotonin in neural or target tissues. Hepatic monoamine oxidase has a crucial defensive role in inactivating circulating monoamines or those, such as tyramine, that originate in the gut and are absorbed into the portal circulation. (From Goodman and Gilman's, The Pharmacological Basis of Therapeutics, 8th ed, p415) EC 1.4.3.4.Probucol: A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).Diet: Regular course of eating and drinking adopted by a person or animal.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Overweight: A status with BODY WEIGHT that is above certain standard of acceptable or desirable weight. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal "over fat".Time Factors: Elements of limited time intervals, contributing to particular results or situations.MinnesotaIsradipine: A potent antagonist of CALCIUM CHANNELS that is highly selective for VASCULAR SMOOTH MUSCLE. It is effective in the treatment of chronic stable angina pectoris, hypertension, and congestive cardiac failure.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Blood Pressure: PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Blood Pressure Determination: Techniques for measuring blood pressure.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Meclizine: A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.Cyclizine: A histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced vomiting and in motion sickness. (From Martindale, The Extra Pharmacopoeia, 30th ed, p935)Copyright: It is a form of protection provided by law. In the United States this protection is granted to authors of original works of authorship, including literary, dramatic, musical, artistic, and certain other intellectual works. This protection is available to both published and unpublished works. (from Circular of the United States Copyright Office, 6/30/2008)Trimethoprim-Sulfamethoxazole Combination: This drug combination has proved to be an effective therapeutic agent with broad-spectrum antibacterial activity against both gram-positive and gram-negative organisms. It is effective in the treatment of many infections, including PNEUMOCYSTIS PNEUMONIA in AIDS.Anaphylaxis: An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.Sulfamethoxazole: A bacteriostatic antibacterial agent that interferes with folic acid synthesis in susceptible bacteria. Its broad spectrum of activity has been limited by the development of resistance. (From Martindale, The Extra Pharmacopoeia, 30th ed, p208)Trimethoprim: A pyrimidine inhibitor of dihydrofolate reductase, it is an antibacterial related to PYRIMETHAMINE. It is potentiated by SULFONAMIDES and the TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION is the form most often used. It is sometimes used alone as an antimalarial. TRIMETHOPRIM RESISTANCE has been reported.Muscle Cramp: A sustained and usually painful contraction of muscle fibers. This may occur as an isolated phenomenon or as a manifestation of an underlying disease process (e.g., UREMIA; HYPOTHYROIDISM; MOTOR NEURON DISEASE; etc.). (From Adams et al., Principles of Neurology, 6th ed, p1398)Injections, Intravenous: Injections made into a vein for therapeutic or experimental purposes.Skin: The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

Profiles of aprindine, cibenzoline, pilsicainide and pirmenol in the framework of the Sicilian Gambit. The Guideline Committee for Clinical Use of Antiarrhythmic Drugs in Japan (Working Group of Arrhythmias of the Japanese Society of Electrocardiology). (1/17)

The Vaughan Williams classification has been used widely by clinicians, cardiologists and researchers engaged in antiarrhythmic drug development and testing in many countries throughout the world since its initial proposal in the early 1970s. However, a major criticism of the Vaughan Williams system arose from the extent to which the categorization of drugs into classes I-IV led to oversimplified views of both shared and divergent actions. The Sicilian Gambit proposed a two-dimensional tabular framework for display of drug actions to solve these problems. From April to December 1996, members of the Guideline Committee met to discuss pharmacologic profiles of 4 antiarrhythmic drugs (aprindine, cibenzoline, pilsicainide, and pirmenol) that were not included in the original spreadsheet but are used widely in clinical practice in Japan. The discussion aimed to fit the drug profiles into the Gambit framework based on all the important literature published to date regarding the actions of the 4 drugs. This report is a summary of that deliberation.  (+info)

Inhibitory effects of aprindine on the delayed rectifier K+ current and the muscarinic acetylcholine receptor-operated K+ current in guinea-pig atrial cells. (2/17)

In order to clarify the mechanisms by which the class Ib antiarrhythmic drug aprindine shows efficacy against atrial fibrillation (AF), we examined the effects of the drug on the repolarizing K+ currents in guinea-pig atrial cells by use of patch-clamp techniques. We also evaluated the effects of aprindine on experimental AF in isolated guinea-pig hearts. Aprindine (3 microM) inhibited the delayed rectifier K+ current (IK) with little influence on the inward rectifier K+ current (IK1) or the Ca2+ current. Electrophysiological analyses including the envelope of tails test revealed that aprindine preferentially inhibits IKr (rapidly activating component) but not IKs (slowly activating component). The muscarinic acetylcholine receptor-operated K+ current (IK.ACh) was activated by the extracellular application of carbachol (1 microM) or by the intracellular loading of GTPgammaS. Aprindine inhibited the carbachol- and GTPgammaS-induced IK.ACh with the IC50 values of 0.4 and 2.5 microM, respectively. In atrial cells stimulated at 0.2 Hz, aprindine (3 microM) per se prolonged the action potential duration (APD) by 50+/-4%. The drug also reversed the carbachol-induced action potential shortening in a concentration-dependent manner. In isolated hearts, perfusion of carbachol (1 microM) shortened monophasic action potential (MAP) and effective refractory period (ERP), and lowered atrial fibrillation threshold. Addition of aprindine (3 microM) inhibited the induction of AF by prolonging MAP and ERP. We conclude the efficacy of aprindine against AF may be at least in part explained by its inhibitory effects on IKr and IK.ACh.  (+info)

Inhibitory effect of aprindine on Na+/Ca2+ exchange current in guinea-pig cardiac ventricular myocytes. (3/17)

1. Using the whole-cell voltage clamp technique, the effect of aprindine on Na+/Ca2+ exchange current (I(NCX)) was examined in guinea-pig single cardiac ventricular myocytes and CCL39 fibroblasts expressing a dog cardiac Na+/Ca2+ exchanger (NCX1). 2. I(NCX) was recorded by ramp pulses from the holding potential of -60 mV with the external solution containing 140 mM Na+ and 1 mM Ca2+, and the pipette solution containing 20 mM Na+, 20 mM BAPTA and 13 mM Ca2+ (433 nM free Ca2+). 3. External application of aprindine suppressed I(NCX) in a concentration-dependent manner. The IC50 values of outward (measured at 50 mV) and inward (measured at -100 mV) I(NCX) components were 48.8 and 51.8 microM with Hill coefficients of 1.3 and 1, respectively. 4. Intracellular application of trypsin via the pipette solution did not change the blocking effect of aprindine, suggesting that aprindine does not affect the exchanger from the cytoplasmic side. 5. Aprindine inhibited I(NCX) of a mutant NCX1 with a deletion of amino acids 247 - 671 in the large intracellular domain between the transmembrane segments 5 and 6 in a similar manner to that of the wild-type, suggesting that the site of aprindine inhibition is not in the large intracellular domain of NCX1. 6. A kinetic study indicated that aprindine was cooperatively competitive with KB-R7943, another inhibitor of NCX and that aprindine was a competitive inhibitor with respect to external Ca2+. 7. We conclude that aprindine may modestly inhibit I(NCX) in a therapeutic range of concentrations (around 2.5 approximately 6.9 microM) possibly at an external or intra-membranous site of the exchanger.  (+info)

Double-blind placebo-controlled trial of aprindine and digoxin for the prevention of symptomatic atrial fibrillation. (4/17)

A multicenter, placebo-controlled, randomized, double-blind trial compared the preventive effect of aprindine and digoxin on the recurrence of atrial fibrillation (AF) with placebo, and also compare the effectiveness of these 2 drugs in the prevention of AF. Patients with symptomatic paroxysmal or persistent AF who had converted to sinus rhythm (SR) were randomly assigned aprindine (40 mg/day), digoxin (0.25 mg/day) or placebo and followed up on an outpatient basis every 2 weeks for 6 months. Of the 141 patients from 36 participating centers, 47 were given aprindine, 47 digoxin, and 47 were on placebo. After the 6-month follow-up, the Kaplan-Meier estimates of the percentage of patients remaining free of recurrent symptomatic AF on aprindine, digoxin and placebo were 33.3%, 29.2% and 21.5%, respectively. In patients remaining in SR for 15 days after from the start of follow-up, freedom from recurrence was significantly more prevalent in the aprindine group than in the placebo group (p=0.0414), but there was no significant difference between the digoxin and placebo groups. The rate of adverse events was similar in the 3 groups. In conclusion, neither aprindine nor digoxin had a significant effect on preventing relapse of symptomatic AF; however, recurrence of AF occurred later with aprindine than with placebo or digoxin.  (+info)

Antiarrhythmic effect of aprindine on several types of ventricular arrhythmias. (5/17)

The antiarrhythmic effect of aprindine was compared with those of lidocaine and propranolol on several ventricular arrhythmias-epinephrine arrhythmias in cats, ouabain arrhythmias in cats and guinea pigs, ischemic ventricular arrhythmias in coronary-ligated Beagle dogs. Antiarrhythmic effects of aprindine and lidocaine were observed both in ouagain and ischemic arrhythmias, but not in epinephrine arrhythmias. While propranolol had a strong antiarrhythmic effect against epinephrine and ouabain arrhythmias, it did not increase sinus beats in ischemic arrhythmias. Marked anti-arrhythmic effects of aprindine in ischemic arrhythmias were observed in dogs using either single intravenous administration (4 mg/kg) or intravenous infusion (200 mug/kg/min, 2 mg/kg). Antiarrhythmic activity of aprindine is considered to be about twice as strong as that of lidocaine, but lidocaine is less toxic in experimental animals.  (+info)

Atrial fibrillation threshold predicted long-term efficacy of pharmacological treatment of patients without structural heart disease. (6/17)

AIMS: To ascertain if an electrophysiological study could predict long-term efficacy of anti-arrhythmic drugs in the treatment of lone atrial fibrillation. METHODS AND RESULTS: Forty-four patients (36 males, 8 females, age 55.5 +/- 10.6) with paroxysmal atrial fibrillation were enrolled to undergo serial electrophysiological studies at the bedside. Two quadripolar catheters were inserted via the subclavian vein. Disopyramide (D: 2 mg/kg iv), cibenzoline (C: 1.4 mg/kg iv), aprindine (A: 2 mg/kg iv), pilsicainide (P: 2 mg/kg po) and flecainide (F: 3 mg/kg po) were tested. Atrial fibrillation threshold (AFT) was measured as the lowest current amplitude of rapid pacing (50 Hz for 1 s) to induce atrial fibrillation lasting more than 30 s. Before drug treatment, AFT was 3.9 +/- 0.3 mA. Pharmacological treatment raised AFT as follows: D 5.9 +/- 0.9 mA, C 7.6 +/- 1.2 mA, A 8.1 +/-1.1 mA, P 6.0 +/- 0.8 mA, F 7.3 +/- 1.1 mA. Recurrence of atrial fibrillation was observed during 1-year follow-up in 12% of cases when they were treated with a drug that raised AFT by 5 mA or more. On the other hand, the recurrence rate was 87% when patients were treated with a drug that raised AFT by less than 5 mA (P = 0.001). CONCLUSION: AFT was a good predictor of long-term efficacy of pharmacological treatment against atrial fibrillation.  (+info)

Maintenance of sinus rhythm and recovery of atrial mechanical function after cardioversion with bepridil or in combination with aprindine in long-lasting persistent atrial fibrillation. (7/17)

BACKGROUND: The aim of this study was to evaluate pharmacological cardioversion of long-lasting persistent atrial fibrillation (AF) using bepridil in terms of recovery of atrial mechanical function and maintenance of sinus rhythm. Bepridil alone or in combination with aprindine is effective for termination of persistent AF. METHODS AND RESULTS: The study group comprised 38 consecutive patients (24 men, 58.8+/-9.3 years) with successful conversion of persistent AF lasting >1 month either pharmacologically (Group I) or electrically (Group II). Fast Fourier transform analysis of fibrillation waves was performed and fibrillation cycle length (FCL) was calculated from the peak frequency. In Group I, sinus rhythm was pharmacologically restored in 22 patients after an average 30 days (7-49 days) of bepridil administration, either alone (11) or in combination with oral aprindine (11); they were followed up while using the same drugs. In Group II, electrical conversion restored sinus rhythm in 16 patients, and they were followed up with conventional antiarrhythmic drugs other than bepridil and aprindine. After bepridil treatment FCL increased and became significantly longer in Group I than in Group II (190+/-39 vs 150+/-29 ms, p<0.001). Atrial peak velocity in transmitral flow within the first week after cardioversion was greater in Group I than in Group II (68+/-35 vs 32+/-20 cm/s, p<0.05). By Kaplan-Meier analysis, 83% of Group I patients were free of AF recurrence at the 12-month follow-up, compared with 36% in Group II (p<0.005). CONCLUSIONS: In patients with long-lasting AF, pharmacological conversion with bepridil alone or in combination with aprindine recovered atrial mechanical function better and maintained sinus rhythm longer than electrical conversion.  (+info)

Drug-induced changes in fibrillation cycle length and organization index can predict chemical cardioversion of long-lasting atrial fibrillation with bepridil alone or in combination with aprindine. (8/17)

BACKGROUND: The aim of this study was to investigate whether drug-induced changes in fibrillation wave characteristics can predict pharmacological conversion of long lasting persistent atrial fibrillation (AF). METHODS AND RESULTS: The study group comprised 23 consecutive patients with AF lasting > or =1 month. Patients first received bepridil (200 mg/day) for 2-4 weeks. When sinus rhythm was not restored with bepridil, oral aprindine (40 or 60 mg/day) was added to bepridil. Fast Fourier transform analysis of fibrillation waves using lead V1 was performed to calculate the fibrillation cycle length (FCL). The spectral areas were measured and the maximum area divided by the total area was termed the fibrillation organization index (FOI). Sinus rhythm was restored in 16 of 23 patients (70%); 8 of these 16 patients received only bepridil (Group I) and the other 8 responders received bepridil and aprindine (Group II). In Group I bepridil increased both FCL (p<0.001) and FOI (p<0.01) and terminated AF after 20+/-12 days. In Group II bepridil increased FCL (p<0.001), but did not change FOI. The addition of aprindine terminated AF in association with an increase in both FCL (p<0.005) and FOI (p<0.005) within 19+/-8 days. In the remaining 7 patients who did not have restoration of sinus rhythm, bepridil increased both FCL and FOI significantly, but less than in Group I, and the addition of aprindine did not further increase either of them. Chemical cardioversion of AF occurred in all patients with FCL > or =190 ms and FOI > or =45% after drug administration. CONCLUSION: Bepridil alone or in combination with aprindine converted long lasting persistent AF in association with an increase in both FCL and FOI. The combination of FCL and FOI after drug administration is helpful in predicting chemical cardioversion of persistent AF.  (+info)

It is well known that amiodarone is effective for the treatment of atrial fibrillation. However, effects of amiodarone on the muscarinic acetylcholine receptor-operated K+ current (IK.ACh), which plays an important role in the repolarization of atrial action potential, have not been evaluated. This study was undertaken to determine whether amiodarone inhibits the acetyl-choline-sensitive muscarinic K+ (KACh) channel by use of the patch-clamp technique. In isolated guinea pig atrial cells, IK.ACh was activated by extracellular application of carbachol (1 microM) or adenosine (10 microM) or by the intracellular loading of GTP gamma S (100 microM). Amiodarone inhibited the IK.ACh activated in these three different ways with similar IC50 values around 2 microM, which indicated that amiodarone directly depresses the function of the KACh channel itself and/or GTP-binding proteins. Single KACh channel current was also recorded by use of a pipette solution containing carbachol (1 microM) or atropine (10 ...
The present study was undertaken to determine whether class Ic antiarrhythmic agents, flecainide and pilsicainide, improve ischemia/reperfusion-induced cardiac contractile dysfunction. Isolated rat hearts were subjected to a 35-min global ischemia, followed by a 60-min reperfusion, and the functional and metabolic consequences were examined. Ischemia/reperfusion resulted in no recovery of contractile function and a sustained rise in left ventricular and diastolic pressure of the perfused heart during reperfusion. The ischemia/reperfusion also induced increases in tissue sodium and calcium levels, decreases in potassium and magnesium ion contents and the release of creatine kinase and purine nucleosides and bases (ATP metabolites) from the heart, suggesting a pronounced change in cardiac transmembrane flux of ions, substrates and macromolecules. Treatment of the perfused heart with either 5 to 50 microM flecainide or 10 to 100 microM pilsicainide during preischemia resulted in diminishing the ...
BRASS Representative to theRUSA Standards and Guidelines Committee Establishment of PositionEstablished in 1988 Purpose of the RUSA CommitteeThe Standards and Guidelines Committee is responsible for advising the RUSA Board of Directors on standards and guidelines for the delivery of reference information service
The Early Career Task Force (ECTF) of the ISTH is committed to exposing early career members to diverse opportunities within ISTH which are avenues for both professional and career development and collaborations. One of these opportunities is creating or editing guidance and guideline documents, an effort led by the Guidance and Guidelines committee (G&G) of the ISTH. In this two-part series, the ISTH first published an early career researchers experience writing an SSC recommendation. In this second article the ISTH spoke with Jim Douketis, M.D., G&G committee member and co-author with Jeff Weitz, M.D., of a call to action paper in JTH: Guidance, guidelines, and communications. J Thromb Haemost 2014; 12: 1744-1745. See the Q&A below:. 1. Since the publication of the guidance, guidelines, and communications commentary in JTH, how have readers responded to your call for participation? Are you seeing increased proposals submissions or inquiries? Jim Douketis: There are a number of manuscripts ...
Dear Members of the USDA Dietary Guidelines Committee:. I wrote to you eight years ago to thank you and all the previous committees for your tireless work on the USDAs dietary guidelines. As I explained back then, your guidelines and the federally approved school lunches based on them are giving my daughters a competitive advantage in life by causing other kids to become tired, experience difficulty concentrating in class, etc.. My prediction that my daughters would bypass most of their classmates is looking pretty good, by the way. My older daughter was recently selected to participate in a math competition. Only the top 50 math students from her high schools 900 freshmen and sophomores were invited. She ended up with the highest score among the 50.. Granted, her math abilities are largely genetic. But when I see her eating brain-building foods like fatty meats and eggs while so many of her classmates live on "heart healthy" vegetable oils, processed grains and other frankenfoods, I cant ...
In an effort to address the concerns and suggestions of vintage karters, the VKA Guidelines Committee would like to hear from you. Please keep in mind that a major purpose of VKA is to create guidelines for promoters and tracks to use that will create consistency between events for vintage karters all across the country. Your concerns and suggestions should focus on period correct karting that occurred up until 1987 ...
At 5 years from diagnosis, the disease-free survival was 68.8 percent in the standard treatment group versus 77.6 percent in the maintenance group. The 5-year overall survival rates were 73.7 percent with standard therapy and 86.5 percent with maintenance therapy.. The most common side effect in the maintenance group was low blood cell count, though it was usually mild, Bisogno explained. Febrile neutropenia occurred in 25 percent of patients. Infection rates were much lower with maintenance treatment than after initial standard chemotherapy, and neurologic side effects resolved after treatment ended. Long-term side effects are still possible, and patients will continue to be monitored, he noted.. "Maintenance treatment toxicity in comparison with standard treatment showed less anemia, neutropenia, and thrombocytopenia (fewer transfusions); fewer infection episodes; and no cardiac/hepatic/gastrointestinal/renal toxicity," said Bisogno.. The findings of this trial have already changed the ...
In 2013, renowned Boston Childrens Hospital pain researcher Clifford Woolf, MD, PhD, and Kai Johnsson, PhD, his fellow co-founder at Quartet Medicine, believed they held the key to non-narcotic pain relief. Woolf had shown that tetrahydrobioptrin - a protein also known as BH4 - is a primary natural modulator of neuropathic and inflammatory pain sensitivity. Quartet was founded on the premise that inhibiting BH4 production could prevent the progression of acute pain to chronic pain in millions of patients, without threat of addiction or tolerance.. With solid human genetic data and chemical biology, plus $17 million in series A funding, Quartet looked primed for success. But in the summer of 2017, toxicology studies of the companys lead candidate revealed neurologic side effects. Hope for the promising pain drug cratered, taking Quartet with it.. Now, however, a surprising discovery about BH4 will likely rekindle interest in the once-promising pathway and could have profound implications for ...
send great you know the download gambits 1983 and workman Symbols( if other). crying Learning without Limits is on one of the most old monarchs in download gambits 1983 06 pedagogy. In the maximum download captains in England are expressed a point towards scutching all elements into values, warning a whole to their commodities and living what they take imperfect of assuming.
Here you will find packages of Gambit code contributed by users. This page is meant as a simple repository where random code snippets as well as complex systems can easily be stored so that other users can get to them. This is not a substitute for a repository that is closely coupled with the Gambit systems module system (which is under development). It is meant to foster the sharing of code by making it extremely easy to publish code in a publicly accessible place. Sharing a piece of code that is incomplete, undocumented, and unreliable is better than not sharing it, because others can correct the deficiencies, learn from the code, or avoid the bugs. Hence the name Dumping Grounds for this page. The code need not follow a specific structure. It could simply be a Scheme source file (with a .scm extension). However, if you are packaging your code specifically for storing it here, it is best if the name of the package contains a revision number (so that many revisions can be stored) and is a gzip ...
Here you will find packages of Gambit code contributed by users. This page is meant as a simple repository where random code snippets as well as complex systems can easily be stored so that other users can get to them. This is not a substitute for a repository that is closely coupled with the Gambit systems module system (which is under development). It is meant to foster the sharing of code by making it extremely easy to publish code in a publicly accessible place. Sharing a piece of code that is incomplete, undocumented, and unreliable is better than not sharing it, because others can correct the deficiencies, learn from the code, or avoid the bugs. Hence the name Dumping Grounds for this page. The code need not follow a specific structure. It could simply be a Scheme source file (with a .scm extension). However, if you are packaging your code specifically for storing it here, it is best if the name of the package contains a revision number (so that many revisions can be stored) and is a gzip ...
α1B, forex gambit mkv commercral penicillin-streptomycm - forex gambit mkv, chart forex fx, forex box com, forex data feed providers
CFA submitted the following comments to the Dietary Guidelines Advisory Committee. The comments urge the Committee to support an accurate, up-to-date depiction of the science linking alcohol and cancer in the next edition of the Dietary Guidelines for Americans. Drinking alcohol is the third most important cause of cancer that is within a persons control, behind smoking and obesity, and ahead of exposure to ultraviolet radiation. Most consumers in the United States, however, remain unaware of the link between alcohol use and cancer.. Past editions of the Dietary Guidelines for Americans may have contributed to the confusion by touting studies that purport to demonstrate cardiovascular and other health benefits from moderate alcohol consumption. Many of those studies, however, have not withstood scrutiny. By contrast, the scientific evidence linking alcohol consumption to cancer is well-established, and growing. Researchers have documented that as little as one drink per day contributes to a ...
Since the inception of the Canadian Cardiovascular Society heart failure (HF) guidelines in 2006, much has changed in the care for patients with HF. Over the past decade, the HF Guidelines Committee has published regular updates. However, because of the major changes that have occurred, the Guidelines Committee believes that a comprehensive reassessment of the HF management recommendations is presently needed, with a view to producing a full and complete set of updated guidelines. The primary and secondary Canadian Cardiovascular Society HF panel members as well as external experts have reviewed clinically relevant literature to provide guidance for the practicing clinician ...
Chronic hepatitis B virus infection remains a global problem of staggering proportions. It is estimated that 350 million people worldwide are chronically infected with the hepatitis B virus (HBV) and sub-Saharan Africa remains a high prevalence region. Most carriers will not develop significant hepatic disease but 15 - 40 % will develop serious sequelae during their lifetime.
At the recent Swiss Re/The BMJ Food for Thought conference, the closing speakers tried to find some agreement on dietary fat guidelines. You can listen to the exchange between Professor Dariush Mozaffarian, Professor Salim Yusuf and Dr Fiona Godlee here.. Fiona started with: "The point about saturated fat is: the evidence is now looking pretty good, but the guidance hasnt shifted… there doesnt seem to have been an enormous mea culpa from the scientific community that we got it so wrong. That does surprise me.". Salim replied: "We got brainwashed by a very questionable study, called The Seven Countries Study, many years ago and it was ingrained in our DNA and generations of us were brought up with that… Somebody said that you need to wait for guidelines committees to die before you can change the guidelines committees"!. Fiona then said: "Maybe one outcome of this meeting would be for this meeting to say thats gone now, the science has changed. Am I right Salim? Am I right Dariush? It ...
At the recent Swiss Re/The BMJ Food for Thought conference, the closing speakers tried to find some agreement on dietary fat guidelines. You can listen to the exchange between Professor Dariush Mozaffarian, Professor Salim Yusuf and Dr Fiona Godlee here.. Fiona started with: "The point about saturated fat is: the evidence is now looking pretty good, but the guidance hasnt shifted… there doesnt seem to have been an enormous mea culpa from the scientific community that we got it so wrong. That does surprise me.". Salim replied: "We got brainwashed by a very questionable study, called The Seven Countries Study, many years ago and it was ingrained in our DNA and generations of us were brought up with that… Somebody said that you need to wait for guidelines committees to die before you can change the guidelines committees"!. Fiona then said: "Maybe one outcome of this meeting would be for this meeting to say thats gone now, the science has changed. Am I right Salim? Am I right Dariush? It ...
A Xanatos Gambit is a plan for which all foreseeable outcomes benefit the creator - including ones that superficially appear to be failure. The …
The Glast Gambit: Hotfix 19.5.7 For those that missed Devstream #85, the cyst cure is aimed to come next week on PC. NOTE: if you were using the ...
Warning: Parameter 3 to processSchemeCodeTag() expected to be a reference, value given in /Users/gambit/Sites/wiki/includes/parser/Parser.php on line 3333 ...
We chat with Channing Tatum about re-introducing Gambit into the X-Men movie universe and slowly fitting him into his Marvel Comics costume.
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
... appointed by the EAP Governing Board: Ethical Guidelines Committee, Science and Research Committee,Training Accreditation Committee, ...
N.B. Please sign the NICE Guidelines Committee petition - see below. There was some encouraging feedback from the recent NICE ME/CFS Guidelines Stakeholder meeting, an early milestone in the long process of revising the guidelines. But was such encouragement justified? I wasnt there myself, so I am grateful to those who attended on our behalf.…
NICE decides to Fully Update its guideline on ME/CFS! Following the stakeholder consultation, NICE have announced they will now commence a FULL REVIEW of the guideline for ME/CFS, effectively overturning previous expert advice not to update it.. The following has been taken from the NICE website, and was shared across social media:. Sir Andrew Dillon, NICE chief executive, said:. "The strong message from stakeholders was that the continuing debate about the causes of this condition and the best approach to treatment argued for a review of the current guideline.". "We will now recruit a guideline committee which will include people with the condition and their carers, the healthcare professionals who treat them and the organisations which commission that treatment. As with all the guidance we produce, we will also ensure that stakeholders have the opportunity to provide evidence and insights throughout the development of the guideline.". CFS/ME is a relatively common condition affecting around ...
Eat your 12 to 15 servings of carbohydrate per day (a great source of energy!), then beat down your blood sugar with more insulin. Thats how dietitians are trained to think. When Charevas father was in the hospital for surgery some months back, he was of course given meals approved by the staff dietitian. For breakfast, he was served pancakes with maple syrup … but no butter on those pancakes, because butter will kill ya, doncha know.. These registered imbeciles believe that if you shoot enough insulin to beat your blood sugar down to the normal range, it means youre okay now - same as if you kept your blood sugar in the normal range by cutting back on the carbs instead.. No. No, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, no, damnit, its not the same.. If youre a type 1 diabetic and you need injections to achieve a normal level of insulin, thats fine. Youre just replacing what your body fails to produce.. But if ...
Why this is important The guideline committee noted the lack of evidence on the diagnosis of active TB in children. The disease manifests differently in children than in adults, and more evidence would have been useful to the committee. Cross-sectional studies are needed to examine the relative accuracy of different tests, and the most appropriate specimen type for these tests, compared with tests currently in use. In particular, the poor accuracy of many tests in children means that diagnostic strategies - that is, combinations of tests - should be investigated, including both tests with high sensitivity and tests based on host response. ...
The 2015 Clinical Practice Guidelines summarize the evidence from approximately 354 randomized controlled trials in the area of critical care nutrition since 1980.. The included studies have undergone a formal review process by the Canadian Clinical Practice Guidelines Committee and provide the latest and best evidence for clinical practice in the various areas of critical care nutrition. These guidelines were developed in collaboration with the Canadian Critical Care Society (CCCS) and the Canadian Critical Care Trials Group (CCCTG).. List of new randomized controlled trials included under each topic (n=41). ...
Amir Qaseem, MD, PhD, MHA; Timothy J. Wilt, MD, MPH; Robert Rich, MD; Linda L. Humphrey, MD, MPH; Jennifer Frost, MD; Mary Ann Forciea, MD; for the Clinical Guidelines Committee of the American College of Physicians and the Commission on Health of the Public and Science of the American Academy of Family ...
David A. Hanley, Ann Cranney, Glenville Jones, Susan J. Whiting, William D. Leslie, David E.C. Cole, Stephanie A. Atkinson, Robert G. Josse, Sidney Feldman, Gregory A. Kline, Cheryl Rosen and ; for the Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada ...
David A. Hanley, Ann Cranney, Glenville Jones, Susan J. Whiting, William D. Leslie, David E.C. Cole, Stephanie A. Atkinson, Robert G. Josse, Sidney Feldman, Gregory A. Kline, Cheryl Rosen and ; for the Guidelines Committee of the Scientific Advisory Council of Osteoporosis Canada ...
After a nearly-transient childhood, Micheal hitchhiked across the country and ran out of money in Arizona. So he stayed there for thirty years, raising dogs, getting a degree in Philosophy, and founding a scientific instrument company. Having read virtually everything by the old Masters of SF&F, he decided he was ready to write. A decade later, with a little help from the Critters online critique group, he was actually ready. He was relieved to find that writing novels is easier than writing software, as a single punctuation error wont cause your audience to explode and die. When he ran out of dogs, he moved to Australia to raise his daughter with her cousins. Now he is a father, author, and immigrant. Fitzgerald was wrong. There are second acts to some American lives, even if they start in other countries ...
There was a time when it was okay to have one consumer electronics company specialize in building one product and another company building another, with both businesses working together-yet apart-to keep the technology sector humming along. Thanks to Apples unbridled success-the companys stock passed $500 this week and it is worth more than Google and Microsoft combined-it has become...
This is a list of changes made recently to pages linked from a specified page (or to members of a specified category). Pages on your watchlist are bold ...
We get all kinds of stuff in the mail from publicists – from cool to weird to downright dirty. Last week, the Gambit Weekly mailbox...
Trailing in the Democratic presidential race, Bernie Sanders has one last gambit. He wants to persuade the partys superdelegates-officeholders, lumina ...
Until then, we take another look at one of the many gifted and talented people you can find at deviantART, the website for artists to post their work and participate in an online community. You get the full gambit at DA, from kids just starting out, to guys like me who are sort of in the medium area, to full-on GODS in the professional comic world, like Adam Hughes, Tim Townsend, Jim Lee and others, who put images of their work up, write journals and talk to one another. I also maintain my own deviantART page, which if you ever feel adventurous you can always check it out ...
In the Twitter-storm furor over Turings recent one-drug price gouge attempt, the media has overlooked the reality that Martin Shkreli was created by the system. Shkreli is merely a rogue trying to play the gambit that Valeant has perfected. And there you have it: boost the prices of dozens of drugs in the span of 1-3 years anywhere between 100% and 800% and nobody notices (thank you insurance companies). But hike the price of one drug by 5,500% and suddenly all of America thinks you are satan incarnate.
Shortening of atrial fibrillation cycle length (AFCL) is a marker of atrial electrical remodelling due to atrial fibrillation (AF). To investigate the effect of detomidine administration on AFCL measured invasively from an intra-atrial electrog
The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident.. Optimal experimental design (OD) describes the procedure of maximizing relevant information in drug development and drug treatment processes. While various optimization criteria can be considered in OD, the most common is to optimize the unknown model parameters for an upcoming study. To date, OD has mainly been used to optimize the independent variables, e.g. sample times, but it can be used for any design variable in a study.. This thesis addresses the OD of multiple continuous or discrete design variables for nonlinear mixed effects models. The methodology for optimizing and the optimization of different types of models with either continuous or discrete data are presented and the benefits of OD for such ...
Schizophrenia is a serious and disabling psychiatric disorder affecting approximately 1% of the worlds population, with its economic cost in the United States alone estimated to exceed that of all cancers combined. The new generation of atypical antipsychotics introduced over the past decade have comparable or greater efficacy than traditional antipsychotics in treating the psychotic symptoms of schizophrenia and a much improved neurologic side effect profile. Quetiapine, the fourth atypical antipsychotic marketed in the United States, was approved by the U.S. Food and Drug Administration in September 1997 and is also currently approved in over 70 countries worldwide for the treatment of psychosis associated with schizophrenia. This article will review the clinical trials examining the efficacy, safety, and tolerability of quetiapine in the treatment of patients with schizophrenia. J Clin Psychiatry 2002;63(suppl 13):12-20. ...
The concept that "atrial fibrillation begets atrial fibrillation" might have some important clinical implications. First of all it emphasizes that most of our electrophysiological knowledge stems from acute experiments and that we know relatively little about chronic electrophysiological adaptation processes. If it is true that the long-term shortening of atrial refractoriness during fibrillation is based on a fundamental change in composition of the ion channels responsible for repolarization of the atrial cells, the action of antiarrhythmic drugs on fibrillating atria may be different than the effects as measured during sinus rhythm. The clinically observed diminished efficacy of chemical cardioversion after a prolonged period of atrial fibrillation9 10 11 12 might be explained by such a process of electrical remodeling. In fact it might be imperative to reevaluate the effects of existing anti-fibrillatory drugs in chronically fibrillating hearts. On the other hand it opens the possibility to ...
The Singapore-MIT Gambit Game Lab is intended for clever types to make clever games, and look, they done gone done that with Improviso. Its a 2D multiplayer
Topic summary contributed by volunteer(s): Linda The U.S. federal dietary guidelines have been challenged by the salt, sugar, dairy, egg, and meat industries since the release of the first recommendations in 1977. These fights continue today with the recent sugar industry attack on the WHOs recommendation to limit the intake of added sugars, the egg industry fight against the American Heart Associations recommendation to consume less eggs for heart health, and the meat industry prevention of any discussion on the scientific research for the health consequences of eating meat during the creation of the 2010 dietary guidelines. Food industries have even funded an analysis of misleadng studies in an attempt to prove that there is no significant evidence of health risk from saturated fat.. Some findings have been widely adopted by the guidelines committee such as the fact that dry peas, lentils, chickpeas, and beans are excellent for optimizing diabetes control. In general, the latest U.S. ...
ISSUES IN RESEARCH. The SAPIT trial provides essential evidence on risks and benefits of integrated and sequential treatment of HIV and tuberculosis. Quarraisha Abdool Karim; Salim S Abdool Karim; Cheryl Baxter; Gerald Friedland; Tanuja Gengiah; Andrew Gray; Anneke Grobler; Kogieleum Naidoo; Nesri Padayatchi; Wafaa El-Sadr. Boulle et al.1 queried whether a clinical trial was needed to provide the evidence for the mortality benefits of antiretroviral therapy (ART) initiation during tuberculosis (TB) treatment. While several experts, including foremost TB-HIV scientists from South Africa2 and the USA,3 senior World Health Organization (WHO)4 and UNAIDS5 officials at the time the study was initiated, the 2003 WHO AIDS Treatment Guidelines Committee Chair3, the Chair of the Ethics Committee6 and the researchers,7 have previously addressed the points raised, the SAPIT (Starting Antiretroviral Therapy at Three Points in Tuberculosis) research team welcomes the opportunity also to address the comments. ...
James WD, Berger TG, Elston DM. Dermatoses resulting from physical factors. In: James WD, Berger TG, Elston DM, eds. Andrews Diseases of the Skin: Clinical Dermatology. 12th ed. Philadelphia, PA: Elsevier; 2016:chap 3.. Marston WA. Wound care. In: Sidawy AN, Perler BA, eds. Rutherfords Vascular Surgery and Endovascular Therapy. 9th ed. Philadelphia, PA: Elsevier; 2019:chap 115.. Qaseem A, Humphrey LL, Forciea MA, Starkey M, Denberg TD; Clinical Guidelines Committee of the American College of Physicians. Treatment of pressure ulcers: a clinical practice guideline from the American College of Physicians. Ann Intern Med. 2015;162(5):370-379. PMID: 25732279 www.ncbi.nlm.nih.gov/pubmed/25732279. ...
The scientific quality of our program has been excellent and we remain the second largest echo meeting in North America! We are blessed to have many outstanding Canadian faculty members who are nationally and internationally recognized, and who serve on several international echo guidelines committees. Planning for our 2019 Annual Echo Weekend is underway - stay tuned. As a CSE member, you will gain substantial savings for the weekend. Please mark your calendar.The registration website will be up in Jan 2019. ...
OneLogin is an access administration arrangement character that empowers undertakings to secure all applications for their clients on all gadgets. OneLogin conveys speed and uprightness to the cutting edge venture with grant winning items for single sign-on and multi-factor confirmation. The items are a piece of its more extensive cloud-based identity, access management and identity-as-a-service arrangement.. Pre-coordinated with a huge number of uses, OneLogin empowers information technology groups to just and safely tie the organizations index framework to its business applications. This gives IT unified access control and the ability to authorize administer based security strategies. In addition, OneLogin empowers multi-factor validation, robotizes client provisioning, and effortlessly gives an account of character strategy consistence.. With OneLogin, undertakings can reinforce security, while dispensing with index mix costs and lessen secret word inconvenience ticket stack. End clients can ...
Population pharmacokinetic data, adjusted for patient characteristics, are recommended for the design of initial dosage regimens of some therapeutically monitored drugs in patients for whom patient-specific data are not available. However, despite widespread use by clinicians such as pharmacists, a clear understanding of the principles of population pharmacokinetics, including data collection and analysis and its limitations, is often lacking. This article describes the 2 main methods of obtaining population kinetic data, namely the two-stage method and nonlinear mixed effect model, and their applications to the pharmacokinetic-based design of dosage regimens. Additionally, some numerical examples are provided to assist the reader in understanding the material. The author uses these tools in a pharmacokinetics course taught to PharmD students.
The cost of releasing a new drug on the market has increased rapidly in the last decade. The reasons for this increase vary with the drug, but the need to make correct decisions earlier in the drug development process and to maximize the information gained throughout the process is evident.. Optimal experimental design (OD) describes the procedure of maximizing relevant information in drug development and drug treatment processes. While various optimization criteria can be considered in OD, the most common is to optimize the unknown model parameters for an upcoming study. To date, OD has mainly been used to optimize the independent variables, e.g. sample times, but it can be used for any design variable in a study.. This thesis addresses the OD of multiple continuous or discrete design variables for nonlinear mixed effects models. The methodology for optimizing and the optimization of different types of models with either continuous or discrete data are presented and the benefits of OD for such ...
Henri Lonchay, Joseph Cuvelier and Joseph Lefevre, vol. University Press, 1986), download the revenues of the many Coast evaluate us in the Apple of our Eye. Zur Bedeutung Antwerpens als Kreditplatz im beginnenden 17. Ennen( Bonn: Rohrscheid, 1972), society analgesia I Nieuwe Tijdinghen, 33( Antwerp: Abraham Verhoeven, 9 March 1622).
|p|Set includes a beautiful glass chess set, 70 faceted glass shaders and a 360 enviroment with 5 material presets.|/p| |p|Chess set includes all the pieces and a board that you can load individual or as a scene preset with the pieces already parented to
download how to play members, American Iron and Steel Institute( AISI) discourses, network programs, study techniques, and was pre outputs. list REINFORCED COMPOSITE DESIGN. download how to play the scotch to such catchment, research and design of solid improvements for different settings.
At the turn of the century, in the year 2000 or so, I started to learn HTML and made my first websites to support my teaching. On a lark, I took an old analysis I had written up of the Urusov Gambit (which had been published my freshman year of college in The Castled King, which later became The Atlantic Chess News) and put it up on the web. It was just a long page of text with some links. But it was still much deeper analysis than anything else I had seen in print. I remember thinking that someone might stumble across it and wed correspond.. Well, someone did--and pretty quickly too. A player named Max Burkett from Montana was using the line in correspondence and had put together an extensive games database for the Pitt Chess Archive. He came across my site and we began corresponding by email. He told me about his database and urged me to expand my analysis in light of those games. He also told me to get a copy of Fritz and use it to help me analyze more deeply. It took me a year or two to ...
Even though his subject matter in later years was exclusively landscape, many of the paintings, of individual rocks or tree stumps, begin to look like out-door still life painting.. And I dont know of another painter who stayed so consistently close to a square or very-nearly-square format for so much of his work. For him it was a compositional gambit that continued to yield interesting results for years.. ...
Mann (Gambit: King of Thieves; The Complete Collection) renders dynamic action and somber moments of conversation and reflection equally well, while the narrative by King (Mister Miracle) explores some fascinating corners of many classic characters psyches and the toll that war takes on even the mightiest warriors with nuance and sensitivity. Unfortunately, the plot feels increasingly padded as it progresses, and the bafflingly complicated solution to the mystery is far from satisfying. Collects the entire nine-issue limited series ...
Brewers 4, Cubs 3: Despite all of the early-season pub, and despite last nights blowout, Im fairly certain that the Brewers arent going to go away all season. Kerry Wood blew yet another save -- this one of those two-run-lead-in-the-ninth varieties -- wasting a strong performance from Carlos Zambrano (6.1 IP, 1 ER). In other news, the Alfonso Soriano-in-the-leadoff-spot gambit didnt work, as he went 0-4. The guy I would put there -- Fukudome -- was 4-4. The guys batting second and third -- Theroit and Lee -- were a combined 4-8 with zero RBI. Something tells me that the Cubs would have had an extra run or two if the batting order were filp-flopped. After a pretty miserable start, Ryan Braun (3-5, 2B, HR, 3 RBI) has been heating up lately ...
Reasonable care has been taken by Kindred in the design, layout and content of this site. However, to the extent permitted by applicable law, Kindred disclaims all warranties, express or implied, as to the accuracy of the information contained in any materials within this site.. Kindred or Families for Conscious Living shall not be liable to any person for any loss or damage, which may arise from the use of any of the information contained within this site.. Links within this site will lead to sites which are not under the control of Kindred or FCL. When you activate these you will leave the Kindred site. Kindred and FCL will not accept any responsibility or liability for the material on any other site as Kindred and FCL has no control over any other site.. ...
Its crucial that you analyze the results of drugs on channels, even though the assembly of HCN isoforms Docetaxel ic50 in native If channels has not been recognized. The Vaughan Williams classification of antiarrhythmic drugs has been used extensively by clinicians, cardiologists, and researchers for quite a while. After the report of the Cardiac Arrhythmia Suppression Trial, a two dimensional tabular composition of the Sicilian Gambit has been proposed to show actions of anti-arrhythmic drugs on ion channels and receptors. However, aftereffects of antiarrhythmic drugs on If havent been carefully analyzed, and only alinidine and aprindine were demonstrated to inhibit the current. Details about the effects of antiarrhythmic drugs on the pacemaker current would be useful for a more rational utilization of antiarrhythmic drugs in the clinical setting. The goal of this study was to look at Chromoblastomycosis the result of varied antiarrhythmic drugs on the HCN4 channel current using patch clamp ...
Most liver transplant recipients receive an immunosuppressive drug regimen that contains either cyclosporine or tacrolimus. Although these drugs have revolutionized transplantation, in many patients their long-term use is a major cause of serious side effects, including kidney failure, hypertension, diabetes mellitus, hyperlipidemia, and/or neurologic side effects. Stopping or reducing the dose of cyclosporine or tacrolimus can ameliorate the above side effects but may increase the risk of rejection. Mycophenolate mofetil (MMF), a safe and effective immunosuppressant that does not cause the above side effects, is typically used in combination with cyclosporine or tacrolimus. Attempts in liver transplant recipients at using mycophenolate mofetil alone or with reduced dose cyclosporine or tacrolimus have been successful but some patients developed rejection, and a few patients suffered liver failure. Most rejections after liver transplantation are easy to successfully treat with increased ...
We previously introduced a new mapping technique for the analysis of AF (wave mapping).1 Following the methods of Rogers et al,15 an algorithm was developed that decomposed the complex spatiotemporal activation during AF into its individual elements (multiple fibrillation waves). Three types of fibrillation waves were distinguished: peripheral waves, which enter the mapping area from outside; EB waves, which appear at the epicardial surface inside the mapping area; and discontinuous conduction fibrillation waves, which start at the lateral boundary of another fibrillation wave with a time delay of 13 to 40 ms.. The following criteria had to be met to classify a fibrillation wave as originating from EB. First, the EB site had to be activated earlier than all surrounding electrodes. If a neighboring electrode was activated at the same time as the EB site, this electrode should be activated earlier than its surrounding electrodes. Second, the EB site must be located at least 2 electrodes from the ...
Had you asked Todd Harper at age 17 -- a music education major at the University of Wisconsin - Madison, 11 year euphonium and choir veteran -- if someday he would be a researcher at MIT studying games, theres a good chance hed have laughed at such an absurd claim. Yet 15 years and one doctorate later, here he is, a postdoctoral researcher at GAMBIT.. After getting his bachelors degree in Radio/TV/Film at Madison in 2001, he worked in distance learning and web editing at Indiana State University before moving to his hometown of Syracuse for a masters in Media Studies at Syracuse University, and then to Ohio University for a recently-completed doctorate in Mass Communications. His research combines a focus on digital games with an interest in feminist and queer theory and popular culture.. When he is not doing actual research on games, Todd spends a good deal of time playing them; his favorites tend to be over the top fighting games and RPGs that appeal to his campy sense of aesthetics. ...
ACC/AHA guidelines for the evaluation and management of chronic heart failure in the adult: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Revise the 1995 Guidelines for the Evaluation and Management of Heart Failure)." Hunt S.A., Baker D.W., Chin M.H., Cinquegrani M.P., Feldman A.M., Francis G.S., Ganiats T.G., Goldstein S., Gregoratos G., Jessup M.L., Noble R.J., Packer M., Silver M.A., Stevenson L.W. The Journal of the American College of Cardiology, 2001 (38: 2101-13).. ...
Dr. Guan is a board-certified genetic counselor and social behavioral scientist. She holds a Masters of Science in Genetic Counseling and a PhD in Public Health from Johns Hopkins University. Her research work has focused on translational research in precision public health: communication research to develop and evaluate effective communications of genomic information, implementation and dissemination research to promote the adoption of evidence-based genomic applications in public health, and community engagement research to expand the reach of genomic screening programs to underserved minority populations. Dr. Guan has served on multiple national committees, including the American Board of Genetic Counselors (ABGC) Research Committee and the National Society of Genetic Counselors (NSGC) Practice Guideline Committee. ...
Clinical Guidelines Committee of the American College of Physicians (ACP) released recommendations for diagnostic imaging for low back pain. These guidelines are the first in a series to help physicians and patients identify potentially misused medical treatments and to practice high-value healthcare. [email protected] ...
How does a chemistry text remain a leader in its field for 80 years?Ever since Physical Chemistry was first published in 1913 (then titled Outlines...
Yes, I ended up being at the hospital for about 3-4 hours. They took me in right away... something about not being able to breathe makes the Emergency staff a little nervous. They immediately put me on one of those Nebulizer breathing machines where you have the mask on and are breathing in oxygen and a medication that is similar to the Puffers. They then hooked me up to an IV and gave me the steroid Prednisone and a big old bag of Magnesium which was infused over a couple of hours. Within minutes of being on the Nebulizer machine, the panic left, I could actually breath air into my lungs and could talk again. Of course, the also took another xray and ran the gambit of blood tests. Heart and organs are all fine. Lungs are clear, no sign of inflammation or pneumonia. Everything is just tickety-boo except I couldnt breathe... how weird! The emergency doc explained it that, since Im on chemo, my immune system has really taken a beating and of course it is compromised, meaning it cant fight off ...
It incorporates to download arithmetic functions we set in the famous and Even were or were north put we met. experience; site and front can continue called So in data of exploratory cenotes in which the sunset is the patients of effective incidents or songs with demonstrated researchers in access charged on future history. The home-brewed music causes replaced modern style and works to the eligibility to mean strong books HealthHealthy as electronic graffiti. download arithmetic functions and; have paid to issue official and challenged to people really challenging that these tyrants live hereby teach Shungite on the R of accessingthe device. place; to deal that it is not needed on study of able sanctuary and is the silence trying paper about comfortable or own Encodements. This related bro needs not determined by the Archetypal related continent that is garb and gambit. 38 In the facilities of Bohm and Peat: When difficult chips are accessed in the spiritual download arithmetic functions and ...
In this edition of The Week in Spandex, we look at Thor: Ragnarok, Spider-Man: Homecoming, Venom, Ant-Man and the Wasp, Avengers 4, Guardians of the Galaxy Vol. 2, Black Panther, Inhumans, Agents of S.H.I.E.L.D., The Punisher, Runaways, Deadpool 2, X-Men: Dark Phoenix, Gambit, The Gifted, Justice League, Flashpoint, Nightwing, Wonder Woman, The Joker, Aquaman, Suicide […]. ...
In this edition of The Week in Spandex, we look at X-Men, Fantastic Four, Deadpool 2, The New Mutants, X-Men: Dark Phoenix, Gambit, The Gifted, Avengers 4, Black Panther, Thor: Ragnarok, Spider-Man: Homecoming 2, Spider-Man: Into the Spider-Verse, Venom, Jessica Jones, The Punisher, Runaways, Agents of S.H.I.E.L.D., New Warriors, Justice League, Aquaman, Shazan, Nightwing, Flashpoint, […]. ...
Im not really sure how key ideas are to conservative political revival. But what Gingrich offers doesnt really qualify as ideas. Instead, call them "ideas." Instead of thinking about ways to solve problems in peoples lives, Gingrich is good at offering ways to package predetermined special-interest priorities as solutions to things that arise. As an opposition gambit, I think this probably works fine. Its good for raising money, so it ensures that you can stay in the game. And it gives you talking points to go on TV with. Eventually the governing party will screw up, and in youll come. But at the same time, the considerable shortcomings to this approach as a governing philosophy is precisely what brought the GOP to this point - it leads to catastrophic screw-ups that prompt massive public disapproval ...
For Bhupesh & Ritika, life was not a cake walk and their love story was served on anything but a silver platter. If you think only parents approval is the biggest villain in a love story, I would say it was a multi starring with gambit of villains age difference, parental pressure, Fraudster son of non existential MP, long-distance relationship, MBA program, Hepatitis A, Coma and Bhupeshs resolution to get over his past so that he can justify his present and his future ahead. ...
By intention or not, Times Person of the Year gambit carried an eerie overtone. Gazing into that silvery panel on the front of the magazine, the reader sees not a clear image of himself but rather a woozy, funhouse version. In all our heightened acuity of seeing, hearing and creating a digitized world, our Big Brotherish powers to watch stars and politicians self-destruct and idle away our midnights tracking lonelygirl15 and her millions of fellow video citizens, there is also a bleary solipsism, a sense that we are finally more fascinated with our fascination than with anything else. The fact that lonelygirl, like her literary counterpart J.T. LeRoy, turned out to be a fictional miasma conjured up to resemble a real person telling real stories about herself, seemed perfectly apt. Nobody, speed-clicking to the next phenomenon, really seemed to mind. "Welcome to your world," as Time put it. ...
Medline: [exp Atrial fibrillation OR AF.mp OR atrial fibrillation.mp] AND [exp electric countershock OR cardioversion.mp OR exp anti arrhythmia agents OR chemical cardioversion.mp] AND [exp heparin OR heparin.mp OR exp heparin, low molecular weight OR low molecular weight heparin.mp OR fractionated heparin.mp OR bemiparin.mp OR certoparin.mp OR dalteparin.mp OR oxaparin.mp OR reviparin.mp OR tinzaparin.mp OR fragmin.mp OR clexane.mp OR exp warfarin or warfarin.mp OR exp coumarins OR coumarins.mp OR exp aspirin OR aspirin.mp] LIMIT to human AND English language ...
CCS position paper on the standardized approaches to the investigation of syncope. The manuscripts associated with these summary presentations are in press and will be published in the Canadian Cardiovascular Society (CCS) journal in 2011.. Guidelines are one of the highest priorities for the CCS.. "Feedback and surveys from the CCS membership and the broader cardiovascular community tell us that CCS guidelines are among our most important functions," says CCS president Dr. Charles Kerr. "As we embark on each new guideline project, we endeavor to identify strong co-chairs and expert panels so we can continue to support Canadian cardiovascular health care practitioners in delivering the highest level of evidence-based care.". This year, the CCS guidelines committee, chaired by Dr Michelle Graham, has overseen the release four position statements and four guidelines.. "This hard working group is responsible for selecting the topics each year for CCS guideline and position statements and ensuring ...
But the video does not try to refute the notion that meats environmental footprint is cause for concern-the UN argues, for instance, that livestock produce 14.5 percent of global greenhouse gas emissions. The Dietary Guidelines committee points out that producing one calorie of beef requires 18 times as much fuel as producing one calorie of grain.. Its no coincidence that the committee chose to flag the carbon footprint of our food: The guidelines are ultimately about peoples relationship with food, and the deterioration of the environments health is a blow to our food security. "Meeting current and future food needs," the committee notes, will depend on changing the way people eat and developing agricultural and production practices "that reduce environmental impacts and conserve resources.". So will the Dietary Guidelines retain this responsible language when they are officially published this fall by the departments of Health and Human Services and Agriculture? On Wednesday, Secretary of ...
Dr. Richard Kamin is an actively practicing emergency physician and an Associate Professor of Emergency Medicine at the University of Connecticut Health Center, where he is the EMS Program Director. Dr. Kamin also serves as the Medical Director for the Connecticut Department of Public Health Office of EMS. Dr. Kamin received both his Bachelors of Science and medical degree from the University of Washington in Seattle. Dr. Kamin subsequently completed a residency in Emergency Medicine and EMS Fellowship at the University of Connecticut. Dr. Kamin is certified by the American Board of Emergency Medicine and is proud to be in the second group of physicians board certified in EMS.. Dr. Kamin is a member of the Committee for Tactical Emergency Casualty Care Board of Directors, after having served as a Guidelines Committee member. Dr. Kamin is an active member of the National Association of State EMS Officials (NASEMSO) Medical Directors Council, and a Co-PI on the NASEMSO National Model EMS Clinical ...
Most studies carried out so far have used fecal samples, assuming that these buy prozac cheap samples have a similar distribution to the communities present throughout the colon. Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma. Process limitations of a whole-cell P450 catalyzed reaction using a CYP153A-CPR fusion construct expressed in Escherichia coli.. Relationship between blood lipids and radiation injury in rabbits. This response was completely abolished when buy zithromax 500mg the cells were incubated in the presence of the AT1-selective receptor antagonist losartan. Nonlinear mixed effects model analysis of the pharmacokinetics of routinely administered bepridil in Japanese patients with arrhythmias.. Twenty-one consecutive patients with nonorganic visual acuity loss buy gabapentin and 21 subjects with organic visual loss as controls were included. Giant exomphalos can be successfully managed using ...
so many centuries after the Creation it is unlikely that anyone could find hitherto unknown lands of any value. - Committee advising Ferdinand and Isabella regarding Columbus proposal, 1486. I would sooner believe that two Yankee professors lied, than that stones fell from the sky. - Thomas Jefferson, 1807 on hearing an eyewitness report of falling meteorites.. Drill for oil? You mean drill into the ground to try and find oil? Youre crazy. - Drillers who Edwin L. Drake tried to enlist to his project to drill for oil in 1859.. Louis Pasteurs theory of germs is ridiculous fiction. - Pierre Pachet, Professor of Physiology at Toulouse, 1872. [Oracs note: This one is particularly amusing to me, given that so many alties reject Pasteurs theory in favor of Beauchamps. Here, they seem to want to have it both ways. They reject Pasteur when arguing against antibiotics, claiming that bacteria are not the cause of disease, or attacking vaccines as useless and harmful. However, they have no problem ...
Alison Blaire was lead singer in the heavy metal band Dazzler, known for its obscene lyrics and spectacular visual effects (secretly supplied by her mutant powers). After two less-than-successful records, Ali considered outing herself as a mutant for extra publicity. Before she could, she was approached by teacher Emma Frost, who was forming a group of young mutant spokespeople to distance the current presidential administration from the X-Men. Uninterested in Frosts politics, Ali said she would join in exchange for a record deal, a requirement she reiterated when the X-Men tried to recruit her. Ali joined Ms. Frosts group, the New Mutants. However, an anti-mutant military faction programmed giant robot Sentinels to attack the groups introductory press conference. The X-Men, on hand for the event, counterattacked and defeated the Sentinels. The anti-mutant conspirators were exposed, and Professor X offered Ms. Frosts charges a place at his own school. Ali was the only one to accept, albeit ...
DanganRonpa Reload is a murder mystery visual novel that takes its trade very seriously, and not much else at the same time. A combination of western and eastern gaming and entertainment traditions that creates a wonderful orchestra for the eyes and mind. Whether you are a child full of hope entering his prime in high school or a wide eyed energetic one looking to have fun on a far away island, your life will be filled with despair. You are desperately trapped in a school or island after being deceived into coming there, with the crazed Monokuma keeping you imprisoned to play through his sick game of murder she wrote. The key to winning is to kill everyone around you without anyone being all the wiser, and the only way to run that gambit is to go through the trials where you must pick apart everything you have figured out.. DR Reload infuses the beautiful hues and dark expressions of anime and comics alike to energize the experience. Visual novel is a good way to generalize this game, but ...
DanganRonpa Reload is a murder mystery visual novel that takes its trade very seriously, and not much else at the same time. A combination of western and eastern gaming and entertainment traditions that creates a wonderful orchestra for the eyes and mind. Whether you are a child full of hope entering his prime in high school or a wide eyed energetic one looking to have fun on a far away island, your life will be filled with despair. You are desperately trapped in a school or island after being deceived into coming there, with the crazed Monokuma keeping you imprisoned to play through his sick game of murder she wrote. The key to winning is to kill everyone around you without anyone being all the wiser, and the only way to run that gambit is to go through the trials where you must pick apart everything you have figured out.. DR Reload infuses the beautiful hues and dark expressions of anime and comics alike to energize the experience. Visual novel is a good way to generalize this game, but ...
Fantastic Four - Issue: 256. Year: 1983. Publisher: Marvel. Writer: Byrne, John. Penciler: Byrne, John. Inker: Byrne, John. Letterer: Novak, Jim. Colorist: Wein, Glynis. Cover: Byrne, John. Comments: The annihilation gambit!. ...
Second, the idea of taxing oil and gas companies and using the revenues to lower gas taxes on consumers is transparently a shell game. It is just moving taxes from the consumer (end user) to the producer. But how do producers stay in business? Why, they pass on costs (including higher government taxes) to - who else? - consumers. So the relief for consumers would be very short-lived. But the government is engaging here in very short term thinking; the clue in the article is the concern for the summer driving season. The government fears consumer outrage this summer. (By the way, gasoline is already the equivalent of more than $9.00 US per gallon, which is more than twice the price in the US and Canada.) This is a gambit to get to the Fall; that is how far ahead the government is thinking. [LACK OF COURAGE ...
Autism increase Statistics [Autism was rare before mass (DPT) vaccination, however the vaccine boys try and disguise that fact by disinformation gambits, the favourite being change in diagnosis, not forgetting Autism and genetics. Now it is 1 in 60, more than that in some areas. They will carry on until every other kid has autism,…
2008 $ 54.6 Trillion as of June 2008 The world became addicted to debt!. Then the housing bubble busted, and with it the gigantic Ponzi scheme.. Creditors are now faced with a dilemma, what to do with the loads and loads of dollar toilet paper, now derisively referred to as "toxic wastes" - stand pat, sell down, continue to be paid in dollar toilet papers or shut down the printing press?. We are now at this juncture.. THE SHADOW MONEY-LENDERS LAST GAMBIT. The Feds decision to cut the Fed Fund Rates to 0.25 percent means that the Fed has embarked on a Zero-Interest-Rate Policy (ZIRP) and to proceed with the policy of Quantitative Easing (QE) - to turn on the spigot for "limitless supply of credit".. In laymans jargon, to encourage more debts - mortgage debts, credit-card debts, car loans, and more importantly to revive the derivative casino, presently on life support. This was the drug addiction that sustained the global financial system in the last twenty years and more intensely in the last ...
A frantic woman calls 9-1-1 saying her boyfriend shot himself. But the story keeps changing. It takes a risky gambit to unravel the truth.
In the wake of recently announced proposed hospital integrations, please join us for a half day seminar on Integration Opportunities and Issues in the Ontario Health Care Sector, focusing principally on hospitals. Considering the gambit from joint officer positions on the one hand to full mergers on the other and many types of integrations in between, the seminar will look at: ...
Since ventricular fibrillation is the predominate cause of death following experimental coronary occlusion, measurement of the ventricular fibrillation threshold is recommended to assess the value of cardiac revascularization procedures. This determination is quantitative, precise and permits measurement under controlled circumstances. It was dissatisfaction with measurement of mortality rate following coronary occlusion in control and experimental animals (bioassay technic) that led to the adoption of the present more exact method.. Acute ligation of the anterior descending branch of the left coronary artery causes an immediate drop in the fibrillation threshold to one-fifth of normal. This is not changed if one releases the artery and retests the animal with occlusion 5 to 6 months later. Implantation of the internal mammary artery into the myocardium of the left ventricle creates a greater resistance to ventricular fibrillation after coronary occlusion. In animals in which the internal ...
Amiodarone is considered a class III antiarrhythmic drug, but it possesses electrophysiologic characteristics of all four Vaughan Williams classes. Like class I drugs, amiodarone blocks sodium channels at rapid pacing frequencies, and like class II drugs, amiodarone exerts a noncompetitive antisympathetic action. One of its main effects, with prolonged administration, is to lengthen the cardiac action potential, a class III effect. The negative chronotropic effect of amiodarone in nodal tissues is similar to the effect of class IV drugs. In addition to blocking sodium channels, amiodarone blocks myocardial potassium channels, which contributes to slowing of conduction and prolongation of refractoriness. The antisympathetic action and the block of calcium and potassium channels are responsible for the negative dromotropic effects on the sinus node and for the slowing of conduction and prolongation of refractoriness in the atrioventricular (AV) node. Its vasodilatory action can decrease cardiac ...
Dofetilide is a class III antiarrhythmic agent. It is marketed under the trade name Tikosyn by Pfizer, and is available in the United States in capsules containing 125, 250, and 500 µg of dofetilide. It is not available in Europe or Australia. Due to the pro-arrhythmic potential of dofetilide, it is only available by prescription from physicians who have undergone specific training in the risks of treatment with dofetilide. In addition, it is only available by mail order or through specially trained local pharmacies. Dofetilide is used for the maintenance of sinus rhythm in individuals prone to the occurrence of atrial fibrillation and flutter arrhythmias, and for chemical cardioversion to sinus rhythm from atrial fibrillation and flutter. Dofetilide is well absorbed in its oral form, with a bioavailability of >90%. The elimination half-life of dofetilide is roughly 10 hours; however, this varies based on many physiologic factors (most significantly creatinine clearance), and ranges from 4.8 to ...
Objectives:Sepsis is associated with cardiac contractile dysfunction attributed to alterations in Ca2+ handling. We examined the subcellular mechanisms involved in sarcoplasmic reticulum Ca2+ loss that mediate altered Ca2+ handling and contractile dysfunction associated with sepsis.Design:Randomized
1. Beets fight cancer. Studies show beet juice inhibits the formation of cancer-causing compounds, particularly in the colon and stomach. 2. They prevent heart and...
Health stocks are highly sensitive to news about regulatory and legislative change. This week is another test with the latest Republican effort to repeal President Barack Obamas signature healthcare law.
Did the nation heave a sigh of relief when BP announced that their latest gambit to cap the Deepwater Horizon gusher will result in hosing up fifty percent of the leaking oil? If so, the nation may be sighing too soon since the other half of the oil will still collect in underwater plumes and hover all around the Gulf Coast like those baleful mother ships in the most recent generation of alien invasion movies. I shudder to imagine the tonnage of dead wildlife flotsam that will wash up with the tide for years to come. It will seem like a necklace of death for several states, though even that may not be enough to distract them from the more gratifying raptures of Nascar and NFL football. For the moment we can only speculate on what the still-unresolved incident will mean for Americas oil supply. The zeal to prosecute BP for something like criminal negligence has bestirred a Department of Justice comatose during the rape-and-pillage of the US financial system. BP may be driven out of business, ...
I fully agree that some words must go in some places in a verse (be it dactylic hex. or iambic or lyric, it doesnt matter) but I am still a little concerned about your opening gambit ... "next time some commentator says that a word is emphasised because of its place...", or similar. As far as I have seen, O Neill makes no reference to emphasis, he merely considers the placement of prosodic shapes within any certain verse form. I remain more than happy to agree with his, and your, conclusions from that. But what I cannot agree with, which I think you assert but O Neill does not address, is that fact that certain places in a verse are not more, or less, emphatic than others. To wit, I believe that the first piece of information in a Greek sentence IS more emphasised than what follows, be that sentence prose or verse (despite your dismissal of Dennisons scholarship elsewhere on these forums) . The last piece of information supplied is also somewhat emphasised (the listener has been waiting ...
Can extremely low interest rates support higher valuations? Equities are not priced based on short term interest rates which are what the Fed normally controls. Longer term rates, used as a discount factor for cash flows and generally competing with equities for investor favour, do impact equity valuation. To the extent that long term rates reflect inflation expectations, using inflation as a proxy for a discount factor is appropriate in as much as it eliminates fluctuations in real interest rates and provides a more stable valuation tool, free of investor mood swings. This time around, it seems even more appropriate to use inflation rather than long term interest rates. In effect, Bernankes gambit was to bring long term rates low enough to force investors out of fixed income into equities. During the last year, Bernankes bet paid off as reflected by rising P/Es during QE3 while profits stalled. But as the market has begun to prepare and adjust to an eventual tapering by the Fed, long term ...
Gambit to save PM could also help prevent corruption charges against Shas leader Deri, Likuds Haim Katz and David Bitan; UTJ chief Litzman accused of aiding alleged pedophiles
... combinations with psycholeptics C01BB01 Lidocaine C01BB02 Mexiletine C01BB03 Tocainide C01BB04 Aprindine C01BC03 Propafenone ...
... aprindine (INN) aprinocarsen (USAN) aprobarbital (INN) Aprodine aprofene ru:Апрофен (INN) aprosulate sodium (INN) aprotinin ( ...
Alverine Amiodarone Amitriptyline Amlodipine Aprindine Astemizole AY-9944 Benzatropine Bepridil Biperiden Camylofin Carvedilol ...
There are a number of derivatives of 2-aminoindane and its positional isomer 1-aminoindane exist, including: 5-IAI Aprindine ...
... aprindine MeSH D04.615.486.487.500 --- ninhydrin MeSH D04.615.486.487.750 --- phenindione MeSH D04.615.486.875 --- sulindac ...
... is a Class 1b antiarrhythmic agent. In one study, it delayed atrial fibrillation more than digoxin did. It has shown ... Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine ... September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol ... Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff ...
... is a member of the sodium channel blocking class of antiepileptic drugs.[60] This may suppress the release of glutamate and aspartate, two of the dominant excitatory neurotransmitters in the CNS.[61] It is generally accepted to be a member of the sodium channel blocking class of antiepileptic drugs,[62] but it could have additional actions since it has a broader spectrum of action than other sodium channel antiepileptic drugs such as phenytoin and is effective in the treatment of the depressed phase of bipolar disorder, whereas other sodium channel blocking antiepileptic drugs are not, possibly on account of its sigma receptor activity. In addition, lamotrigine shares few side-effects with other, unrelated anticonvulsants known to inhibit sodium channels, which further emphasises its unique properties.[63] It is a triazine derivate that inhibits voltage-sensitive sodium channels, leading to stabilization of neuronal membranes. It also blocks L-, N-, and P-type calcium channels and ...
The hormone prolactin stimulates lactation (production of breast milk). Dopamine, released by the hypothalamus stops the release of prolactin from the pituitary gland. Domperidone, by acting as an anti-dopaminergic agent, results in increased prolactin secretion, and thus promotes lactation (that is, it is a galactogogue). In some nations, including Australia, domperidone is used off-label, based on uncertain and anecdotal evidence of its usefulness, as a therapy for mothers who are having difficulty breastfeeding.[24][25] In the United States, domperidone is not approved for this or any other use.[26][27] A study called the EMPOWER trial was designed to assess the effectiveness and safety of domperidone in assisting mothers of preterm babies to supply breast milk for their infants.[28] The study randomized 90 mothers of preterm babies to receive either domperidone 10 mg orally three times daily for 28 days (Group A) or placebo 10 mg orally three times daily for 14 days followed by domperidone ...
InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27) ...
... (CBZ), sold under the trade name Tegretol among others, is an anticonvulsant medication used primarily in the treatment of epilepsy and neuropathic pain.[1] It is not effective for absence or myoclonic seizures.[1] It is used in schizophrenia along with other medications and as a second-line agent in bipolar disorder.[3][1] Carbamazepine appears to work as well as phenytoin and valproate for focal and generalised seizures.[4] Common side effects include nausea and drowsiness.[1] Serious side effects may include skin rashes, decreased bone marrow function, suicidal thoughts, or confusion.[1] It should not be used in those with a history of bone marrow problems.[1] Use during pregnancy may cause harm to the baby; however, stopping the medication in pregnant women with seizures is not recommended.[1] Its use during breastfeeding is not recommended.[1] Care should be taken in those with either kidney or liver problems.[1] Carbamazepine was discovered in 1953 by Swiss chemist Walter ...
A channel that is "inwardly-rectifying" is one that passes current (positive charge) more easily in the inward direction (into the cell) than in the outward direction (out of the cell). It is thought that this current may play an important role in regulating neuronal activity, by helping to stabilize the resting membrane potential of the cell. By convention, inward current (positive charge moving into the cell) is displayed in voltage clamp as a downward deflection, while an outward current (positive charge moving out of the cell) is shown as an upward deflection. At membrane potentials negative to potassium's reversal potential, inwardly rectifying K+ channels support the flow of positively charged K+ ions into the cell, pushing the membrane potential back to the resting potential. This can be seen in figure 1: when the membrane potential is clamped negative to the channel's resting potential (e.g. -60 mV), inward current flows (i.e. positive charge flows into the cell). However, when the ...
... also binds to and blocks α2δ subunit-containing VDCCs, similarly to gabapentin and pregabalin, and hence is a gabapentinoid.[9][16] Both (R)-phenibut and (S)-phenibut display this action with similar affinity (Ki = 23 and 39 μM, respectively).[9] Moreover, (R)-phenibut possesses 4-fold greater affinity for this site than for the GABAB receptor (Ki = 92 μM), while (S)-phenibut does not bind significantly to the GABAB receptor (Ki , 1 mM).[9] As such, based on the results of this study, phenibut would appear to have much greater potency in its interactions with α2δ subunit-containing VDCCs than with the GABAB receptor (between 5- to 10-fold).[9] For this reason, the actions of phenibut as a α2δ subunit-containing voltage-gated calcium channel blocker or gabapentinoid may be its true primary mechanism of action, and this may explain the differences between phenibut and its close relative baclofen (which, in contrast, has essentially insignificant activity as a gabapentinoid; Ki = 6 ...
InChI=1S/C24H34N2O/c1-21(2)19-27-20-24(25-15-9-10-16-25)18-26(23-13-7-4-8-14-23)17-22-11-5-3-6-12-22/h3-8,11-14,21,24H,9-10,15-20H2,1-2H3 ...
... (marketed as Depamide by Sanofi-Aventis) is a carboxamide derivative of valproic acid used in the treatment of epilepsy and some affective disorders. It is rapidly metabolised (80%) to valproic acid (another anticonvulsant) but has anticonvulsant properties itself. It may produce more stable plasma levels than valproic acid or sodium valproate and may be more effective at preventing febrile seizures. However, it is over one hundred times more potent as an inhibitor of liver microsomal epoxide hydrolase. This makes it incompatible with carbamazepine and can affect the ability of the body to remove other toxins. Valpromide is no safer during pregnancy than valproic acid. Valpromide is formed through the reaction of valproic acid and ammonia via an intermediate acid chloride. In pure form, valpromide is a white crystalline powder and has melting point 125-126 °C. It is practically insoluble in water but soluble in hot water. It is available on the market in some European countries. ...
Class Ib antiarrhythmic agents are sodium channel blockers. They have fast onset and offset kinetics, meaning that they have little or no effect at slower heart rates, and more effects at faster heart rates. Class Ib agents shorten the action potential duration and reduce refractoriness. These agents will decrease Vmax in partially depolarized cells with fast response action potentials. They either do not change the action potential duration, or they may decrease the action potential duration. Class Ib drugs tend to be more specific for voltage gated Na channels than Ia. Lidocaine in particular is highly frequency dependent, in that it has more activity with increasing heart rates. This is because lidocaine selectively blocks Na channels in their open and inactive states and has little binding capability in the resting state. Class Ib agents are indicated for the treatment of ventricular tachycardia and symptomatic premature ventricular beats, and prevention of ventricular fibrillation. Class Ib ...
... has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels.[1] How this effect is mediated and to what extent this mechanism is involved in the anxiolytic and analgesic effects of kavalactones on the central nervous system is unknown. Kavain's pharmacological activities have not been sufficiently investigated, and neither its effect as a serotonin reuptake inhibitor nor its monoamine (norepinephrine) uptake inhibitions and activation of NMDA receptors have been confirmed. The mechanism behind the psychotropic, sedative, and anxiolytic actions of kavain and related kavalactones is still debated. Direct binding to the benzodiazepine/flumazenil binding site of the GABA-A receptor does not occur with kavain enantiomers.[2] Many studies involved kava extracts from different plant parts and are, therefore, not applicable to kavain itself. In 2016, kavain was shown to bind at the α4β2δ GABAA receptor and ...
It is on the WHO Model List of Essential Medicines, the most important medications needed in a basic health system.[4] Magnesium sulfate is a common mineral pharmaceutical preparation of magnesium, commonly known as Epsom salt, used both externally and internally. Magnesium sulfate is highly water-soluble and solubility is inhibited with lipids typically used in lotions. Lotions often employ the use of emulsions or suspensions to include both oil and water-soluble ingredients. Hence, magnesium sulfate in a lotion may not be as freely available to migrate to the skin nor to be absorbed through the skin, hence both studies may properly suggest absorption or lack thereof as a function of the carrier (in a water solution vs. in an oil emulsion/suspension). Temperature and concentration gradients may also be contributing factors to absorption.[5] Externally, magnesium sulfate paste is used to treat skin inflammations such as small boils or localised infections. Known in the UK as 'drawing paste' it ...
... has a potential for drug interactions; caution should be used in combining other medicines with it, including other antiepileptics and mood stabilizers.[12] Lower levels of carbamazepine are seen when administrated with phenobarbital, phenytoin, or primidone, which can result in breakthrough seizure activity. Carbamazepine, as a CYP450 inducer, may increase clearance of many drugs, decreasing their concentration in the blood to subtherapeutic levels and reducing their desired effects.[19] Drugs that are more rapidly metabolized with carbamazepine include warfarin, lamotrigine, phenytoin, theophylline, and valproic acid.[12] Drugs that decrease the metabolism of carbamazepine or otherwise increase its levels include erythromycin,[20] cimetidine, propoxyphene, and calcium channel blockers.[12] Carbamazepine also increases the metabolism of the hormones in birth control pills and can reduce their effectiveness, potentially leading to unexpected pregnancies.[12] As a drug that induces ...
... occludes the pore of calcium-activated voltage-gated shaker K+ channels by binding to one of four independent, overlapping binding sites.[6][7] It binds both to the open and the closed states. In addition, the block is enhanced as the ionic strength is lowered.[8] This block occurs as the Asn 30 on the CTX interacts with the Asp 381 on the K+ channel.[9] The blockade of K+ channels by the charybdotoxin peptide causes neuronal hyperexcitability. Mutations of the Lys31Gln and the Asn30Gln had the effect of lessening the CTX block of the pore on the shaker channel.[9] ...
... has several uses including the treatment of abnormal heart rhythms or arrhythmias, chronic pain, and myotonia. In general when treating arrhythmias, mexiletine is reserved for use in dangerous heart rhythm disturbances such as ventricular tachycardia.[2] It is of particular use when treating arrhythmias caused by long QT syndrome.[3] The LQT3 form of long QT syndrome is amenable to treatment with mexiletine as this form is caused by defective sodium channels that continue to release a sustained current rather than fully inactivating, however other forms of long QT syndrome can also be treated with this medication.[3] Mexiletine has been used to treat chronic pain and may also be used to treat muscle stiffness resulting from myotonic dystrophy (Steinert's disease) or nondystrophic myotonias such as myotonia congenita (Thomsen syndrome or Becker syndrome).[4][5] ...
... is available as a generic medication and usually not too expensive.[7] Wholesale it costs between US$0.003 and US$0.15 per dose.[8] A month of treatment is about US$30 in the United States.[2] Since September 2012, the marketing licence in the UK has been held by Flynn Pharma Ltd, of Dublin, Ireland, and the product, although identical, has been called Phenytoin Sodium xxmg Flynn Hard Capsules. (The xxmg in the name refers to the strength-for example "Phenytoin sodium 25 mg Flynn Hard Capsules").[49] The capsules are still made by Pfizer's Goedecke subsidiary's plant in Freiburg, Germany and they still have Epanutin printed on them.[50] After Pfizer's sale of the UK marketing licence to Flynn Pharma, the price of a 28-pack of 25 mg phenytoin sodium capsules marked Epanutin rose from 66p (about $0.88) to £15.74 (about $25.06). Capsules of other strengths also went up in price by the same factor-2384%,[51] costing the UK's National Health Service an extra £43 million (about $68.44 ...
... is effective for prevention of shivering during surgery or recovery from surgery.[5][6] Nefopam was significantly more effective than aspirin as an analgesic in one clinical trial,[7] although with a greater incidence of side effects such as sweating, dizziness and nausea, especially at higher doses.[8][9] The estimated relative potency of nefopam to morphine indicates that 20 mg of nefopam HCl is the approximate analgesic equal of 12 mg of morphine with comparable analgesic efficacy to morphine,[10][11][12] or oxycodone,[13] while Nefopam tends to produce fewer side effects, does not produce respiratory depression,[14] and has much less abuse potential, and so is useful either as an alternative to opioids, or as an adjunctive treatment for use alongside opioid(s) or other analgesics.[12][15] Nefopam is also used to treat severe hiccups.[16] ...
Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. Buclizine, cyclizine, and meclizine are similar, so any of the above side effects may occur with any of these medicines.. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.. Portions of this document last updated: March 01, 2017. Original article: http://www.mayoclinic.org/drugs-supplements/meclizine-buclizine-and-cyclizine-oral-route-parenteral-route/description/drg-20069630. Copyright © 2017 Truven Health Analytics Inc. All rights reserved. Information is for End Users use only and may not be sold, redistributed or otherwise used for commercial purposes.. ...
Aprindine is a Class 1b antiarrhythmic agent. In one study, it delayed atrial fibrillation more than digoxin did. It has shown ... Atarashi H, Inoue H, Fukunami M, Sugi K, Hamada C, Origasa H (June 2002). "Double-blind placebo-controlled trial of aprindine ... September 1991). "Aprindine blocks the sodium current in guinea-pig ventricular myocytes". Naunyn Schmiedebergs Arch. Pharmacol ... Reid PR, Greene HL, Varghese PJ (December 1977). "Suppression of refractory arrhythmias by aprindine in patients with the Wolff ...
Aprindine Hepatitis H. FRANKLIN HERLONG, M.D.; PHILIP R. REID, M.D.; JOHN K. BOITNOTT, M.D.; WILLIS C. MADDREY, M.D., F.A.C.P. ... The reintroduction of aprindine in one patient was associated with the reappearance of hepatitis, which resolved despite ... We have seen two patients whose hepatitis was due to the administration of aprindine, a new antiarrhythmic agent. In both ... patients evidence of hepatitis appeared within 3 weeks of initiating aprindine therapy and resolved rapidly when the drug was ...
Detailed drug Information for Norpramin. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Do not take this medicine within 2 hours of taking antacids or medicine for diarrhea. Taking these products too close together may make this medicine less effective.. This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.. Before using any prescription or over-the-counter (OTC) medicine for colds or allergies, check with your doctor. These medicines may increase the chance of developing heatstroke or other unwanted effects, such as dizziness, dry mouth, blurred vision, and constipation, while ...
Detailed drug Information for erythromycin and benzoyl peroxide Topical. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Check with your doctor if you used this medicine and your migraine did not go away, or if your migraine got worse or started occurring more often. This medicine may increase your risk of having abnormal heart rhythm, heart attack, angina, or stroke. This is more likely to occur if you or a family member already has heart disease, if you have diabetes, high blood pressure, or if you smoke. Call your doctor right away if you have any symptoms of a heart problem, such as chest pain or discomfort, an uneven heartbeat, nausea or vomiting, pain or discomfort in the shoulders, arms, jaw, back, or neck, shortness of breath, or sweating. Call your doctor right away if you have any symptoms of a stroke, such as confusion, difficulty with speaking, double vision, headaches, an inability to move the arms, legs, or facial muscles, an inability to speak, or slow speech. Check with your doctor right away if you have chest discomfort, jaw or neck tightness after taking this medicine. Also, tell your doctor if ...
This medicine will add to the effects of alcohol and other CNS depressants (medicines that make you drowsy or less alert). Some examples of CNS depressants are antihistamines or medicine for allergies or colds, sedatives, tranquilizers, or sleeping medicine, prescription pain medicine or narcotics, medicine for seizures or barbiturates, muscle relaxants, or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine. This medicine may cause some people to become dizzy, drowsy, or may cause trouble with thinking or controlling body movements, which may lead to falls, fractures or other injuries. Even if you take haloperidol at bedtime, you may feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are dizzy or not alert. Dizziness, lightheadedness, or fainting may occur, especially when you get up from a ...
Detailed drug Information for Duo-Vil 2-10. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. This is due to lowered blood pressure. Getting up slowly may help. This effect does not occur often at doses of disopyramide usually used; however, make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert. If the problem continues or gets worse, check with your doctor.. Disopyramide may rarely cause hypoglycemia (low blood sugar) in some people. (See the Side Effects of This Medicine section below.) If these signs appear, eat or drink a food containing sugar and call your doctor right away.. This medicine may cause blurred vision or other vision problems. If any of these occur, do not drive, use machines, or do anything else that could be dangerous if you are not able to see well.. Disopyramide may cause dryness of the eyes, mouth, and nose. For temporary relief of mouth dryness, use sugarless ...
Contact your doctor right away if you have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation. This medicine may cause sores on the genitals (sex organs). Washing your genitals after urination may decrease the chance of your developing this problem. It is also very important that your ophthalmologist (eye doctor) check your eyes at regular visits since you may have some loss of eyesight due to retinitis even while you are receiving foscarnet injection. This medicine may make you dizzy. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements. ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
Do not take desipramine with a monoamine oxidase (MAO) inhibitor (eg, isocarboxazid [Marplan®], phenelzine [Nardil®], selegiline [Eldepryl®], tranylcypromine [Parnate®]). Do not start taking desipramine during the 2 weeks after you stop a MAO inhibitor and wait 2 weeks after stopping desipramine before you start taking a MAO inhibitor. If you take them together or do not wait 2 weeks, you may develop confusion, agitation, restlessness, stomach or intestinal symptoms, a sudden high body temperature, an extremely high blood pressure, or severe convulsions. Desipramine may cause a serious condition called serotonin syndrome if taken together with some medicines. Do not use desipramine with buspirone (Buspar®), fentanyl (Abstral®, Duragesic®), linezolid (Zyvox®), lithium (Eskalith®, Lithobid®), methylene blue, tryptophan, St. Johns wort, or some pain or migraine medicines (eg, sumatriptan, tramadol, Frova®, Maxalt®, Relpax®, Zomig®). Check with your doctor first before taking any ...
Detailed drug Information for E.E.S. 400 Oral. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
Remember that this medicine will not cure your condition but it does help control it. Therefore, you must continue to take it as directed if you expect to keep your cholesterol levels down.. Follow carefully the special diet your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly.. This medicine works better when taken with meals.. Before prescribing medicine for your condition, your doctor will probably try to control your condition by prescribing a personal diet for you. Such a diet may be low in fats, sugars, and/or cholesterol. Many people are able to control their condition by carefully following their doctors orders for proper diet and exercise. Medicine is prescribed only when additional help is needed and is effective only when a schedule of diet and exercise is properly followed.. Also, this medicine is less effective if you are greatly overweight. It may be very important for you to go on a reducing ...
Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well .. Remember that this medicine will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease .. Swallow the extended-release tablet whole with a full glass of water. Do not break, crush, or chew it .. If you are taking the extended-release tablets, part of the tablet may pass into your stools after your body has absorbed the medicine. This is normal and is nothing to worry about .. ...
Detailed drug Information for spiramycin Oral, Injection, Rectal. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
If you have any questions about this, check with your health care professional.. Many vaginal infections are spread by sexual intercourse. The male sexual partner may carry the fungus or other organism in his reproductive tract. Therefore, it may be desirable that your partner wear a condom (prophylactic) during intercourse to keep the infection from returning. Also, it may be necessary for your partner to be treated at the same time you are being treated to avoid passing the infection back and forth. In addition, do not stop using this medicine if you have intercourse during treatment.. Some patients who use vaginal medicines may prefer to use a douche for cleansing purposes before inserting the next dose of medicine. Some doctors recommend a vinegar and water or other douche. However, others do not recommend douching at all. If you do use a douche, do not overfill the vagina with douche solution. To do so may force the solution up into the uterus (womb) and may cause inflammation or infection. ...
Stomach problems, such as nausea and vomiting, or loss of appetite, are common minor side effects seen in pentamidine treatment. However, if you have these problems, and at the same time have sharp pain in the upper abdomen, or an unusual decrease in the amount of urine, check with your doctor immediately.. Pentamidine may also cause an unpleasant metallic taste. This side effect is to be expected and does not require medical attention.. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.. Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.. Portions of this document last updated: Feb. 01, 2020. Original article: https://www.mayoclinic.org/drugs-supplements/pentamidine-injection-route/description/drg-20065384. Copyright © 2020 IBM Watson Health. All rights reserved. Information is for End Users use only and may not be sold, redistributed or ...
Very rarely, this medicine has caused severe side effects. If you start to have a skin rash, or if you think you are having a severe skin reaction, call your doctor or nurse right away. Symptoms of a severe reaction may include a skin rash, skin color that is very pale or yellow, or skin with purple spots, along with a sore throat, fever, muscle pain, cough, and trouble with breathing.. Check with your doctor right away if you have abdominal or stomach cramps; bloating; watery and severe diarrhea, which may also be bloody; nausea or vomiting; or unusual tiredness or weakness. These may be symptoms of a serious intestinal infection.. This medicine may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Check with your doctor right away if you have a rash; itching; swelling of the face, tongue, and throat; trouble with breathing; shortness of breath; or chest pain after you get the injection.. Before you have any ...
You or your child should not use astemizole (Hismanal®), cisapride (Propulsid®), erythromycin (Ery-Tab®), pimozide (Orap®), quinidine (Cardioquin®), or terfenadine (Seldane®) while receiving this medicine because of the risk of unwanted side effects. Using this medicine for a long time or using it too much while you are pregnant (especially during the first trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using this medicine, tell your doctor right away. This medicine may rarely cause serious liver problems. Check with your doctor right away if you or your child are having more than one of these symptoms: abdominal or stomach pain or tenderness, clay-colored stools, dark urine, decreased appetite, fever, headache, itching, loss of appetite, nausea and vomiting, skin rash, swelling of the feet or lower legs, unusual tiredness or weakness, or yellow eyes or skin. This medicine may rarely ...
Do not receive this medicine if you are also using astemizole (Hismanal®) or terfenadine (Seldane®). Using these medicines together may cause serious unwanted effects. Check with your doctor right away if you or your child have pain or tenderness in the upper stomach; pale stools; dark urine; loss of appetite; nausea; unusual tiredness or weakness; or yellow eyes or skin. These could be symptoms of a serious liver problem. Erythromycin may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using this medicine. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor. This medicine can cause changes in heart rhythms, such as a condition called QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some ...
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.. ...
If your or your childs symptoms do not improve within a few days, or if they become worse, check with your doctor. Do not take halofantrine (Halfan®) or ketoconazole (Nizoral®) with mefloquine or within 15 weeks after the last dose of this medicine. This may increase the risk for more serious problems. Contact your doctor right away if you or your child have any changes to your heart rhythm. You might feel dizzy or faint, or you might have a fast, pounding, or uneven heartbeat. Make sure your doctor knows if you or anyone in your family has ever had a heart rhythm problem such as QT prolongation. Tell your doctor right away if you or your child are feeling anxious, confused, depressed, restless, or having unusual thoughts or behavior after using mefloquine. Check with your doctor right away if you have the following symptoms after taking this medicine: dizziness, feeling of constant movement of self or surroundings, seizures, or trouble sleeping. These symptoms may continue to occur for ...
... and aprindine 141, biperidene 149, buclicine 152, buspiron 154, diosmin 190, emetine 196, encainide 197, fosinopril 211, ... aprindine 141, biperidene 149, carvedilol 160, cepharantine 161, clemastine 170, clofazimine 172, conessine 175, desloratadine ...
  • Aprindine-induced polymorphous ventricular tachycardia. (healthtap.com)
  • Naccarelli GV, Prystowsky EN, Jackman WM, Heger JJ, Rahilly GT, Zipes DP (1982) Role of electrophysiologic testing in managing patients who have ventricular tachycardia unrelated to coronary artery disease. (springer.com)
  • Rahilly GT, Prystowsky EN, Zipes DP, Naccarelli GV, Jackman WM, Heger JJ (1982) Clinical and electrophysiologic findings in patients with repetitive monomorphic ventricular tachycardia and otherwise normal electrocardiogram. (springer.com)
  • Rinkenberger RL, Prystowsky EN, Jackman WM, Naccarelli GV, Heger JJ, Zipes DP (1982) Drug conversion of nonsustained ventricular tachycardia to sustained ventricular tachycardia during serial electrophysiologic studies: Identification of drugs that exacerbate tachycardia and potential mechanisms. (springer.com)
  • Schaeffer AH, Greene HL, Reid PR (1978) Suppression of the repetitive ventricular response: an index of long-term antiarrhythmic effectiveness of aprindine for ventricular tachycardia in man. (springer.com)
  • In both patients evidence of hepatitis appeared within 3 weeks of initiating aprindine therapy and resolved rapidly when the drug was withdrawn. (annals.org)
  • We administered aprindine to dogs before, 5 min after, and 24 h after one-stage left anterior descending coronary artery (LAD) occlusion. (elsevier.com)
  • Nattel, S, Pedersen, DH & Zipes, DP 1981, ' Alterations in regional myocardial distribution and arrhythmogenic effects of aprindine produced by coronary artery occlusion in the dog ', Cardiovascular Research , vol. 15, no. 2, pp. 80-85. (elsevier.com)
  • We have seen two patients whose hepatitis was due to the administration of aprindine, a new antiarrhythmic agent. (annals.org)
  • The reintroduction of aprindine in one patient was associated with the reappearance of hepatitis, which resolved despite continued administration of the drug. (annals.org)
  • Coronary artery occlusion performed after aprindine administration slowed the rate of disappearance of aprindine from the ischaemic zone compared with the normal zone, so that ischaemic zone aprindine concentrations averaged more than twice normal zone aprindine concentrations 1 h after LAD occlusion. (elsevier.com)
  • Prystowsky EN, Heger JJ, Zipes DP (1982) The recognition and treatment of patients at risk for sudden death. (springer.com)