Coronary Restenosis: Recurrent narrowing or constriction of a coronary artery following surgical procedures performed to alleviate a prior obstruction.Prosthesis Design: The plan and delineation of prostheses in general or a specific prosthesis.Sirolimus: A macrolide compound obtained from Streptomyces hygroscopicus that acts by selectively blocking the transcriptional activation of cytokines thereby inhibiting cytokine production. It is bioactive only when bound to IMMUNOPHILINS. Sirolimus is a potent immunosuppressant and possesses both antifungal and antineoplastic properties.Angioplasty, Balloon, Coronary: Dilation of an occluded coronary artery (or arteries) by means of a balloon catheter to restore myocardial blood supply.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Coronary Thrombosis: Coagulation of blood in any of the CORONARY VESSELS. The presence of a blood clot (THROMBUS) often leads to MYOCARDIAL INFARCTION.Coronary Angiography: Radiography of the vascular system of the heart muscle after injection of a contrast medium.Ultrasonography, Interventional: The use of ultrasound to guide minimally invasive surgical procedures such as needle ASPIRATION BIOPSY; DRAINAGE; etc. Its widest application is intravascular ultrasound imaging but it is useful also in urology and intra-abdominal conditions.Blood Vessel Prosthesis Implantation: Surgical insertion of BLOOD VESSEL PROSTHESES to repair injured or diseased blood vessels.Coated Materials, Biocompatible: Biocompatible materials usually used in dental and bone implants that enhance biologic fixation, thereby increasing the bond strength between the coated material and bone, and minimize possible biological effects that may result from the implant itself.Blood Vessel Prosthesis: Device constructed of either synthetic or biological material that is used for the repair of injured or diseased blood vessels.Metals: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)Time Factors: Elements of limited time intervals, contributing to particular results or situations.Cardiovascular Agents: Agents that affect the rate or intensity of cardiac contraction, blood vessel diameter, or blood volume.Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Equipment Design: Methods of creating machines and devices.Foreign-Body Migration: Migration of a foreign body from its original location to some other location in the body.Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.Angioplasty, Balloon: Use of a balloon catheter for dilation of an occluded artery. It is used in treatment of arterial occlusive diseases, including renal artery stenosis and arterial occlusions in the leg. For the specific technique of BALLOON DILATION in coronary arteries, ANGIOPLASTY, BALLOON, CORONARY is available.Coronary Vessels: The veins and arteries of the HEART.Coronary Stenosis: Narrowing or constriction of a coronary artery.Platelet Aggregation Inhibitors: Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system.Coronary Artery Disease: Pathological processes of CORONARY ARTERIES that may derive from a congenital abnormality, atherosclerotic, or non-atherosclerotic cause.Constriction, Pathologic: The condition of an anatomical structure's being constricted beyond normal dimensions.Paclitaxel: A cyclodecane isolated from the bark of the Pacific yew tree, TAXUS BREVIFOLIA. It stabilizes MICROTUBULES in their polymerized form leading to cell death.Absorbable Implants: Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.Prosthesis Failure: Malfunction of implantation shunts, valves, etc., and prosthesis loosening, migration, and breaking.Ticlopidine: An effective inhibitor of platelet aggregation commonly used in the placement of STENTS in CORONARY ARTERIES.Angioplasty: Reconstruction or repair of a blood vessel, which includes the widening of a pathological narrowing of an artery or vein by the removal of atheromatous plaque material and/or the endothelial lining as well, or by dilatation (BALLOON ANGIOPLASTY) to compress an ATHEROMA. Except for ENDARTERECTOMY, usually these procedures are performed via catheterization as minimally invasive ENDOVASCULAR PROCEDURES.Prosthesis Implantation: Surgical insertion of a prosthesis.Percutaneous Coronary Intervention: A family of percutaneous techniques that are used to manage CORONARY OCCLUSION, including standard balloon angioplasty (PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY), the placement of intracoronary STENTS, and atheroablative technologies (e.g., ATHERECTOMY; ENDARTERECTOMY; THROMBECTOMY; PERCUTANEOUS TRANSLUMINAL LASER ANGIOPLASTY). PTCA was the dominant form of PCI, before the widespread use of stenting.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Myocardial Infarction: NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION).Iliac Artery: Either of two large arteries originating from the abdominal aorta; they supply blood to the pelvis, abdominal wall and legs.Equipment Failure: Failure of equipment to perform to standard. The failure may be due to defects or improper use.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Device Removal: Removal of an implanted therapeutic or prosthetic device.Prospective Studies: Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.Tunica Intima: The innermost layer of an artery or vein, made up of one layer of endothelial cells and supported by an internal elastic lamina.Catheterization: Use or insertion of a tubular device into a duct, blood vessel, hollow organ, or body cavity for injecting or withdrawing fluids for diagnostic or therapeutic purposes. It differs from INTUBATION in that the tube here is used to restore or maintain patency in obstructions.Endovascular Procedures: Minimally invasive procedures, diagnostic or therapeutic, performed within the BLOOD VESSELS. They may be perfomed via ANGIOSCOPY; INTERVENTIONAL MAGNETIC RESONANCE IMAGING; INTERVENTIONAL RADIOGRAPHY; or INTERVENTIONAL ULTRASONOGRAPHY.Vascular Patency: The degree to which BLOOD VESSELS are not blocked or obstructed.Recurrence: The return of a sign, symptom, or disease after a remission.Aortography: Radiographic visualization of the aorta and its branches by injection of contrast media, using percutaneous puncture or catheterization procedures.Feasibility Studies: Studies to determine the advantages or disadvantages, practicability, or capability of accomplishing a projected plan, study, or project.Coronary Disease: An imbalance between myocardial functional requirements and the capacity of the CORONARY VESSELS to supply sufficient blood flow. It is a form of MYOCARDIAL ISCHEMIA (insufficient blood supply to the heart muscle) caused by a decreased capacity of the coronary vessels.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Retreatment: The therapy of the same disease in a patient, with the same agent or procedure repeated after initial treatment, or with an additional or alternate measure or follow-up. It does not include therapy which requires more than one administration of a therapeutic agent or regimen. Retreatment is often used with reference to a different modality when the original one was inadequate, harmful, or unsuccessful.Angioscopy: Endoscopic examination, therapy or surgery performed on the interior of blood vessels.Chromium Alloys: Specific alloys not less than 85% chromium and nickel or cobalt, with traces of either nickel or cobalt, molybdenum, and other substances. They are used in partial dentures, orthopedic implants, etc.Angiography: Radiography of blood vessels after injection of a contrast medium.Aortic Aneurysm, Thoracic: An abnormal balloon- or sac-like dilatation in the wall of the THORACIC AORTA. This proximal descending portion of aorta gives rise to the visceral and the parietal branches above the aortic hiatus at the diaphragm.Tubulin Modulators: Agents that interact with TUBULIN to inhibit or promote polymerization of MICROTUBULES.Equipment Failure Analysis: The evaluation of incidents involving the loss of function of a device. These evaluations are used for a variety of purposes such as to determine the failure rates, the causes of failures, costs of failures, and the reliability and maintainability of devices.Drug Implants: Small containers or pellets of a solid drug implanted in the body to achieve sustained release of the drug.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Polytetrafluoroethylene: Homopolymer of tetrafluoroethylene. Nonflammable, tough, inert plastic tubing or sheeting; used to line vessels, insulate, protect or lubricate apparatus; also as filter, coating for surgical implants or as prosthetic material. Synonyms: Fluoroflex; Fluoroplast; Ftoroplast; Halon; Polyfene; PTFE; Tetron.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Tracheal StenosisAspirin: The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)Arterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Radiography, Interventional: Diagnostic and therapeutic procedures that are invasive or surgical in nature, and require the expertise of a specially trained radiologist. In general, they are more invasive than diagnostic imaging but less invasive than major surgery. They often involve catheterization, fluoroscopy, or computed tomography. Some examples include percutaneous transhepatic cholangiography, percutaneous transthoracic biopsy, balloon angioplasty, and arterial embolization.Aortic Aneurysm, Abdominal: An abnormal balloon- or sac-like dilatation in the wall of the ABDOMINAL AORTA which gives rise to the visceral, the parietal, and the terminal (iliac) branches below the aortic hiatus at the diaphragm.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Risk Assessment: The qualitative or quantitative estimation of the likelihood of adverse effects that may result from exposure to specified health hazards or from the absence of beneficial influences. (Last, Dictionary of Epidemiology, 1988)Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Tomography, Optical Coherence: An imaging method using LASERS that is used for mapping subsurface structure. When a reflective site in the sample is at the same optical path length (coherence) as the reference mirror, the detector observes interference fringes.Registries: The systems and processes involved in the establishment, support, management, and operation of registers, e.g., disease registers.Software: Sequential operating programs and data which instruct the functioning of a digital computer.Femoral Artery: The main artery of the thigh, a continuation of the external iliac artery.Swine: Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).Myocardial Revascularization: The restoration of blood supply to the myocardium. (From Dorland, 28th ed)Aneurysm, False: Not an aneurysm but a well-defined collection of blood and CONNECTIVE TISSUE outside the wall of a blood vessel or the heart. It is the containment of a ruptured blood vessel or heart, such as sealing a rupture of the left ventricle. False aneurysm is formed by organized THROMBUS and HEMATOMA in surrounding tissue.Aneurysm, Dissecting: Aneurysm caused by a tear in the TUNICA INTIMA of a blood vessel leading to interstitial HEMORRHAGE, and splitting (dissecting) of the vessel wall, often involving the AORTA. Dissection between the intima and media causes luminal occlusion. Dissection at the media, or between the media and the outer adventitia causes aneurismal dilation.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Reoperation: A repeat operation for the same condition in the same patient due to disease progression or recurrence, or as followup to failed previous surgery.Materials Testing: The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.Iliac Vein: A vein on either side of the body which is formed by the union of the external and internal iliac veins and passes upward to join with its fellow of the opposite side to form the inferior vena cava.Esophageal Stenosis: A stricture of the ESOPHAGUS. Most are acquired but can be congenital.Coronary Aneurysm: Abnormal balloon- or sac-like dilatation in the wall of CORONARY VESSELS. Most coronary aneurysms are due to CORONARY ATHEROSCLEROSIS, and the rest are due to inflammatory diseases, such as KAWASAKI DISEASE.Coronary Occlusion: Complete blockage of blood flow through one of the CORONARY ARTERIES, usually from CORONARY ATHEROSCLEROSIS.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Single-Blind Method: A method in which either the observer(s) or the subject(s) is kept ignorant of the group to which the subjects are assigned.Silicones: A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.Chi-Square Distribution: A distribution in which a variable is distributed like the sum of the squares of any given independent random variable, each of which has a normal distribution with mean of zero and variance of one. The chi-square test is a statistical test based on comparison of a test statistic to a chi-square distribution. The oldest of these tests are used to detect whether two or more population distributions differ from one another.Biocompatible Materials: Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.Palliative Care: Care alleviating symptoms without curing the underlying disease. (Stedman, 25th ed)Carotid Stenosis: Narrowing or stricture of any part of the CAROTID ARTERIES, most often due to atherosclerotic plaque formation. Ulcerations may form in atherosclerotic plaques and induce THROMBUS formation. Platelet or cholesterol emboli may arise from stenotic carotid lesions and induce a TRANSIENT ISCHEMIC ATTACK; CEREBROVASCULAR ACCIDENT; or temporary blindness (AMAUROSIS FUGAX). (From Adams et al., Principles of Neurology, 6th ed, pp 822-3)Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Intestinal Obstruction: Any impairment, arrest, or reversal of the normal flow of INTESTINAL CONTENTS toward the ANAL CANAL.Imaging, Three-Dimensional: The process of generating three-dimensional images by electronic, photographic, or other methods. For example, three-dimensional images can be generated by assembling multiple tomographic images with the aid of a computer, while photographic 3-D images (HOLOGRAPHY) can be made by exposing film to the interference pattern created when two laser light sources shine on an object.Atherectomy, Coronary: Percutaneous transluminal procedure for removing atheromatous plaque from the coronary arteries. Both directional (for removing focal atheromas) and rotational (for removing concentric atheromatous plaque) atherectomy devices have been used.Embolization, Therapeutic: A method of hemostasis utilizing various agents such as Gelfoam, silastic, metal, glass, or plastic pellets, autologous clot, fat, and muscle as emboli. It has been used in the treatment of spinal cord and INTRACRANIAL ARTERIOVENOUS MALFORMATIONS, renal arteriovenous fistulas, gastrointestinal bleeding, epistaxis, hypersplenism, certain highly vascular tumors, traumatic rupture of blood vessels, and control of operative hemorrhage.Cholangiopancreatography, Endoscopic Retrograde: Fiberoptic endoscopy designed for duodenal observation and cannulation of VATER'S AMPULLA, in order to visualize the pancreatic and biliary duct system by retrograde injection of contrast media. Endoscopic (Vater) papillotomy (SPHINCTEROTOMY, ENDOSCOPIC) may be performed during this procedure.Cerebral Angiography: Radiography of the vascular system of the brain after injection of a contrast medium.Aorta, Thoracic: The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Intracranial Aneurysm: Abnormal outpouching in the wall of intracranial blood vessels. Most common are the saccular (berry) aneurysms located at branch points in CIRCLE OF WILLIS at the base of the brain. Vessel rupture results in SUBARACHNOID HEMORRHAGE or INTRACRANIAL HEMORRHAGES. Giant aneurysms (>2.5 cm in diameter) may compress adjacent structures, including the OCULOMOTOR NERVE. (From Adams et al., Principles of Neurology, 6th ed, p841)Thrombectomy: Surgical removal of an obstructing clot or foreign material from a blood vessel at the point of its formation. Removal of a clot arising from a distant site is called EMBOLECTOMY.Popliteal Artery: The continuation of the femoral artery coursing through the popliteal fossa; it divides into the anterior and posterior tibial arteries.Drainage: The removal of fluids or discharges from the body, such as from a wound, sore, or cavity.Subclavian Artery: Artery arising from the brachiocephalic trunk on the right side and from the arch of the aorta on the left side. It distributes to the neck, thoracic wall, spinal cord, brain, meninges, and upper limb.Endoleak: Postoperative hemorrhage from an endovascular AORTIC ANEURYSM repaired with endoluminal placement of stent grafts (BLOOD VESSEL PROSTHESIS IMPLANTATION). It is associated with pressurization, expansion, and eventual rupture of the aneurysm.Renal Artery: A branch of the abdominal aorta which supplies the kidneys, adrenal glands and ureters.Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.Aorta, Abdominal: The aorta from the DIAPHRAGM to the bifurcation into the right and left common iliac arteries.Fluoroscopy: Production of an image when x-rays strike a fluorescent screen.Aortic Coarctation: A birth defect characterized by the narrowing of the AORTA that can be of varying degree and at any point from the transverse arch to the iliac bifurcation. Aortic coarctation causes arterial HYPERTENSION before the point of narrowing and arterial HYPOTENSION beyond the narrowed portion.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Endoscopy: Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.Plastics: Polymeric materials (usually organic) of large molecular weight which can be shaped by flow. Plastic usually refers to the final product with fillers, plasticizers, pigments, and stabilizers included (versus the resin, the homogeneous polymeric starting material). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Biotechnology: Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.Incidence: The number of new cases of a given disease during a given period in a specified population. It also is used for the rate at which new events occur in a defined population. It is differentiated from PREVALENCE, which refers to all cases, new or old, in the population at a given time.Models, Cardiovascular: Theoretical representations that simulate the behavior or activity of the cardiovascular system, processes, or phenomena; includes the use of mathematical equations, computers and other electronic equipment.Surface Properties: Characteristics or attributes of the outer boundaries of objects, including molecules.Swine, Miniature: Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair miniature, and Minnesota miniature.Jaundice, Obstructive: Jaundice, the condition with yellowish staining of the skin and mucous membranes, that is due to impaired BILE flow in the BILIARY TRACT, such as INTRAHEPATIC CHOLESTASIS, or EXTRAHEPATIC CHOLESTASIS.Ultrasonography, Doppler, Duplex: Ultrasonography applying the Doppler effect combined with real-time imaging. The real-time image is created by rapid movement of the ultrasound beam. A powerful advantage of this technique is the ability to estimate the velocity of flow from the Doppler shift frequency.Catheters: A flexible, tubular device that is used to carry fluids into or from a blood vessel, hollow organ, or body cavity.Tracheal DiseasesComputational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Acute Coronary Syndrome: An episode of MYOCARDIAL ISCHEMIA that generally lasts longer than a transient anginal episode that ultimately may lead to MYOCARDIAL INFARCTION.Prolapse: The protrusion of an organ or part of an organ into a natural or artificial orifice.Angina Pectoris: The symptom of paroxysmal pain consequent to MYOCARDIAL ISCHEMIA usually of distinctive character, location and radiation. It is thought to be provoked by a transient stressful situation during which the oxygen requirements of the MYOCARDIUM exceed that supplied by the CORONARY CIRCULATION.Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Models, Animal: Non-human animals, selected because of specific characteristics, for use in experimental research, teaching, or testing.Cardiac Catheterization: Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.Portasystemic Shunt, Transjugular Intrahepatic: A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of esophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (JAMA 1995;273(23):1824-30)Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Angiography, Digital Subtraction: A method of delineating blood vessels by subtracting a tissue background image from an image of tissue plus intravascular contrast material that attenuates the X-ray photons. The background image is determined from a digitized image taken a few moments before injection of the contrast material. The resulting angiogram is a high-contrast image of the vessel. This subtraction technique allows extraction of a high-intensity signal from the superimposed background information. The image is thus the result of the differential absorption of X-rays by different tissues.Severity of Illness Index: Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.Renal Artery Obstruction: Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Aortic Rupture: The tearing or bursting of the wall along any portion of the AORTA, such as thoracic or abdominal. It may result from the rupture of an aneurysm or it may be due to TRAUMA.Brachytherapy: A collective term for interstitial, intracavity, and surface radiotherapy. It uses small sealed or partly-sealed sources that may be placed on or near the body surface or within a natural body cavity or implanted directly into the tissues.Anastomosis, Surgical: Surgical union or shunt between ducts, tubes or vessels. It may be end-to-end, end-to-side, side-to-end, or side-to-side.Coronary Artery Bypass: Surgical therapy of ischemic coronary artery disease achieved by grafting a section of saphenous vein, internal mammary artery, or other substitute between the aorta and the obstructed coronary artery distal to the obstructive lesion.Rabbits: The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.Disease Models, Animal: Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.Randomized Controlled Trials as Topic: Works about clinical trials that involve at least one test treatment and one control treatment, concurrent enrollment and follow-up of the test- and control-treated groups, and in which the treatments to be administered are selected by a random process, such as the use of a random-numbers table.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Gastric Outlet Obstruction: The hindering of output from the STOMACH into the SMALL INTESTINE. This obstruction may be of mechanical or functional origin such as EDEMA from PEPTIC ULCER; NEOPLASMS; FOREIGN BODIES; or AGING.Models, Theoretical: Theoretical representations that simulate the behavior or activity of systems, processes, or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Biosensing Techniques: Any of a variety of procedures which use biomolecular probes to measure the presence or concentration of biological molecules, biological structures, microorganisms, etc., by translating a biochemical interaction at the probe surface into a quantifiable physical signal.Anticoagulants: Agents that prevent clotting.Multicenter Studies as Topic: Works about controlled studies which are planned and carried out by several cooperating institutions to assess certain variables and outcomes in specific patient populations, for example, a multicenter study of congenital anomalies in children.Image Processing, Computer-Assisted: A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.Vertebrobasilar Insufficiency: Localized or diffuse reduction in blood flow through the vertebrobasilar arterial system, which supplies the BRAIN STEM; CEREBELLUM; OCCIPITAL LOBE; medial TEMPORAL LOBE; and THALAMUS. Characteristic clinical features include SYNCOPE; lightheadedness; visual disturbances; and VERTIGO. BRAIN STEM INFARCTIONS or other BRAIN INFARCTION may be associated.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Iatrogenic Disease: Any adverse condition in a patient occurring as the result of treatment by a physician, surgeon, or other health professional, especially infections acquired by a patient during the course of treatment.Ureter: One of a pair of thick-walled tubes that transports urine from the KIDNEY PELVIS to the URINARY BLADDER.Tracheoesophageal Fistula: Abnormal passage between the ESOPHAGUS and the TRACHEA, acquired or congenital, often associated with ESOPHAGEAL ATRESIA.Vascular Surgical Procedures: Operative procedures for the treatment of vascular disorders.Immunoglobulin Fab Fragments: Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN.Aortic Aneurysm: An abnormal balloon- or sac-like dilatation in the wall of AORTA.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Ureteral Diseases: Pathological processes involving the URETERS.Phlebography: Radiographic visualization or recording of a vein after the injection of contrast medium.Product Surveillance, Postmarketing: Surveillance of drugs, devices, appliances, etc., for efficacy or adverse effects, after they have been released for general sale.Pressure: A type of stress exerted uniformly in all directions. Its measure is the force exerted per unit area. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Job Application: Process of applying for employment. It includes written application for employment or personal appearance.Respiratory Tract Fistula: An abnormal passage communicating between any component of the respiratory tract or between any part of the respiratory system and surrounding organs.Phenprocoumon: Coumarin derivative that acts as a long acting oral anticoagulant.Intracranial Arteriosclerosis: Vascular diseases characterized by thickening and hardening of the walls of ARTERIES inside the SKULL. There are three subtypes: (1) atherosclerosis with fatty deposits in the ARTERIAL INTIMA; (2) Monckeberg's sclerosis with calcium deposits in the media and (3) arteriolosclerosis involving the small caliber arteries. Clinical signs include HEADACHE; CONFUSION; transient blindness (AMAUROSIS FUGAX); speech impairment; and HEMIPARESIS.Equipment Safety: Freedom of equipment from actual or potential hazards.Polyurethanes: A group of thermoplastic or thermosetting polymers containing polyisocyanate. They are used as ELASTOMERS, as coatings, as fibers and as foams.Models, Anatomic: Three-dimensional representation to show anatomic structures. Models may be used in place of intact animals or organisms for teaching, practice, and study.Carotid Artery, Internal: Branch of the common carotid artery which supplies the anterior part of the brain, the eye and its appendages, the forehead and nose.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Proportional Hazards Models: Statistical models used in survival analysis that assert that the effect of the study factors on the hazard rate in the study population is multiplicative and does not change over time.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Beta Particles: High energy POSITRONS or ELECTRONS ejected from a disintegrating atomic nucleus.Patient Selection: Criteria and standards used for the determination of the appropriateness of the inclusion of patients with specific conditions in proposed treatment plans and the criteria used for the inclusion of subjects in various clinical trials and other research protocols.Multivariate Analysis: A set of techniques used when variation in several variables has to be studied simultaneously. In statistics, multivariate analysis is interpreted as any analytic method that allows simultaneous study of two or more dependent variables.Medical Informatics Applications: Automated systems applied to the patient care process including diagnosis, therapy, and systems of communicating medical data within the health care setting.Combined Modality Therapy: The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.Diagnostic Imaging: Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.Nanomedicine: The branch of medicine concerned with the application of NANOTECHNOLOGY to the prevention and treatment of disease. It involves the monitoring, repair, construction, and control of human biological systems at the molecular level, using engineered nanodevices and NANOSTRUCTURES. (From Freitas Jr., Nanomedicine, vol 1, 1999).United StatesMagnetic Resonance Angiography: Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.Pilot Projects: Small-scale tests of methods and procedures to be used on a larger scale if the pilot study demonstrates that these methods and procedures can work.Deglutition Disorders: Difficulty in SWALLOWING which may result from neuromuscular disorder or mechanical obstruction. Dysphagia is classified into two distinct types: oropharyngeal dysphagia due to malfunction of the PHARYNX and UPPER ESOPHAGEAL SPHINCTER; and esophageal dysphagia due to malfunction of the ESOPHAGUS.Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Saphenous Vein: The vein which drains the foot and leg.EuropeAnalysis of Variance: A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.Fluorescent Dyes: Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Prosthesis Fitting: The fitting and adjusting of artificial parts of the body. (From Stedman's, 26th ed)Wound Healing: Restoration of integrity to traumatized tissue.Embolism: Blocking of a blood vessel by an embolus which can be a blood clot or other undissolved material in the blood stream.Contrast Media: Substances used to allow enhanced visualization of tissues.Bronchial Fistula: An abnormal passage or communication between a bronchus and another part of the body.
Harvey L. Berger
... such as medical applications and more specifically the coating of drug-eluting stents. Strutt, John William (1945). The Theory ... "Using Ultrasonic Spray Nozzles to Coat Drug-Eluting Stents". Notes Berger, Harvey L. Ultrasonic Liquid Atomization: Theory and ... drug eluting stents and spray drying. Berger died in August 2007 after a struggle with liver cancer. He was survived by his ... Theory and Application in 1998. Being the father of the application of the technology, Harvey Berger was frequently called to ...
Some implants are bioactive, such as subcutaneous drug delivery devices in the form of implantable pills or drug-eluting stents ... Artificial body part replacements are one of the many applications of bionics. Concerned with the intricate and thorough study ... Biomedical engineering (BME) is the application of engineering principles and design concepts to medicine and biology for ... Some examples include the improvement of crop technology (not a medical application, but see biological systems engineering), ...
Some implants are bioactive, such as subcutaneous drug delivery devices in the form of implantable pills or drug-eluting stents ... Implants can roughly be categorized into groups by application. Sensory and neurological implants are used for disorders ... and coronary stent. Orthopaedic implants help alleviate issues with the bones and joints of the body. They're used to treat ...
Fink, Jennifer L.W. (December 2011). "Drug-Eluting Sinus Stent Hits the Market: May help maintain patency after FESS". ENT ... The company holds over 20 issued patents in the United States and more than 80 patents and patent applications worldwide. The ... Fink, Jennifer L. W. (December 2011). "Drug-Eluting Sinus Stent Hits the Market: May help maintain patency after FESS". ENT ... Intersect ENT is best known for developing the first bioabsorbable drug-eluting sinus stent PROPEL, which delivers anti- ...
Christodoulos I. Stefanadis
... external non-invasive heating of stented arterial segments, and evolution and application of bevacizumab-eluting stent for the ... introduced the idea of covering metallic stents by non-thrombotic material and he developed covered stents by autologous ... A new method of detection by application of a special thermography catheter. Circulation. 1999 Apr 20;99(15):1965-71. ... A new method of determination by the application of a special ultrasonic dimension catheter. Circulation. 1995 Oct 15;92(8): ...
... applied to drug-eluting stents, to prevent the occurrence of coronary artery restenosis. The first application of this approach ... Drug-eluting stents (DES) are used by interventional cardiologists, operating on patients with coronary artery disease. The ... coated stents have been implanted in patients with no apparent deleterious effect in the long term compared to bare metal stent ... Polymer coatings of stents that deliver the anti-proliferative drug Zotarolimus to the arterial vessel wall are key components ...
For "on-label" applications, the FDA "believes that coronary drug-eluting stents remain safe and effective when used for the ... Drug-eluting stents generally consist of three parts - the stent platform, a polymer coating that binds the drug to the stent ... As currently used in clinical practice, "drug-eluting" stents refers to metal stents that elute a drug designed to limit the ... Drug-eluting stents also have been shown to be superior to bare-metal stents in reducing short-term complications of stenting ...
2002 The CYPHER® Sirolimus-eluting Coronary Stent, the first drug-eluting stent for patients with coronary heart disease is ... Balloon-Expandable Stent for coronary artery applications. 1996 Cordis joins the Johnson & Johnson interventional business ... 2008 Three million patients worldwide had received the CYPHER® Stent, a milestone unreached by any other drug-eluting stent at ... 2013 Launch of 'Smart Flex Self-Expanding Stent System. The device belongs to a new generation of self-expandable stents for ...
"Cypher Sirolimus-eluting Coronary Stent". Cypher Stent. Retrieved 1 April 2008. Seto B (November 2012). "Rapamycin and mTOR: a ... In this application, rapamycin is added to cells expressing two fusion constructs, one of which contains the rapamycin-binding ... A sirolimus-eluting coronary stent was marketed by Cordis, a division of Johnson & Johnson, under the tradename Cypher. However ... Several large clinical studies have demonstrated lower restenosis rates in patients treated with sirolimus-eluting stents when ...
Some implants are bioactive, such as subcutaneous drug delivery devices in the form of implantable pills or drug-eluting stents ... Biomedical engineering (BME) or medical engineering is the application of engineering principles and design concepts to ... Some examples include the improvement of crop technology (not a medical application, but see biological systems engineering), ... An MRI scan of a human head, an example of a biomedical engineering application of electrical engineering to diagnostic imaging ...
L-605 has also been used in aerospace components and turbine engines as well as drug-eluting and other kinds of stents due to ... "L605 Precipitates and Their Effects on Stent Applications". In Venugopalan, R.; Wu, M. Medical Device Materials III - ... Standard Specification for Wrought Cobalt-20Chromium-15Tungsten-10Nickel Alloy for Surgical Implant Applications (UNS R30605 ...
The use of metal drug-eluting stents presents some potential drawbacks. These include a predisposition to late stent thrombosis ... "Novel magnesium alloys developed for biomedical application: a review". Journal of Materials Science & Technology. ISBN 978-3- ... 2015). "A bioresorbable everolimus-eluting scaffold versus a metallic everolimus-eluting stent for ischaemic heart disease ... offer comparable efficacy and safety profile to drug-eluting stents. Specifically, the Absorb naturally dissolving stent has ...
History of invasive and interventional cardiology
Cordis, the manufacturer of the Cypher drug eluting stent, was not able to keep up with the demand for these stents when they ... Description of a new technique and a preliminary report of its application". Circulation. 30: 654-70. doi:10.1161/01.CIR.30.5. ... The antiplatelet regimens that were advised for the drug eluting stents were based on the early trials of these stents. Based ... 2002). "A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization". N Engl J ...
1985 - Self-expanding stents are developed for vascular and oncological applications. 1990 - Radiofrequency ablation (RFA) ... Drug eluting bead chemoembolization (DEB-TACE): delivery of microparticles that are themselves loaded with the chemotherapy ... 1969 - The catheter-delivered stenting technique and prototype stent. 1970s - Embolisation agents started to be used in ... The interventional radiological treatment known as stenting can be used to re-open blockages, for example of the esophagus or ...
Vascular Business Intravascular ultrasound systems Catheters for the treatment of coronary artery disease Drug-eluting stents ... minimally invasive clinical applications-was acquired. "Terumo Corporate Profile". Retrieved March 17, 2014. "Terumo Financial ... The company later expanded its product range to include coronary stents and catheters, and acquired, among others, the ...
Verification and validation
2008). "Drug-eluting or bare-metal stents forlarge coronary vessel stenting? The BASKET-PROVE (PROspective Validation ... Part I: defining the appropriate compliance standards - application of the principles of FDA GLP and FDA GMP to bioanalytical ... 1996). "Validation of liquid chromatographic and gas chromatographic methods Applications to pharmacokinetics". Journal of ... or installing a new application software and restructuring of the computer which affects especially the pre-settings, such as ...
In treating In-stent restenosis (ISR) Drug Eluting stents (DES) have been found to be superior to Intracoronary Brachytherapy ( ... Applications and Techniques. Philadelphia: LWW. Pieters, B. R.; De Back, D. Z.; Koning, C. C. E.; Zwinderman, A. H. (2009). " ... Applications and Techniques. Philadelphia: LWW. CSIntell. "Brachytherapy Market Recovery to Reach US$ 2.4 Billion". The global ... Brachytherapy can be used in the treatment of coronary in-stent restenosis, in which a catheter is placed inside blood vessels ...
Clinical application of cardiac catheterization begins with Werner Forssmann in 1929, who inserted a catheter into the vein of ... If necessary, the physician can utilize percutaneous coronary intervention techniques, including the use of a stent (either ... bare-metal or drug-eluting) to open the blocked vessel and restore appropriate blood flow. In general, occlusions greater than ... Percutaneous coronary intervention, however, involves the use of mechanical stents to increase blood flow to previously blocked ...
... within stents. Paclitaxel drug eluting coated stents for coronary artery placement are sold under the trade name Taxus by ... BMS filed a new drug application (NDA), which was given FDA approval at the very end of 1992. Although there was no patent on ... Paclitaxel drug eluting coated stents for femoropopliteal artery placement are sold under the trade name Zilver PTX by Cook ... 2001). "Paclitaxel stent coating inhibits neointimal hyperplasia at 4 weeks in a porcine model of coronary restenosis" (PDF). ...
A coronary stent - in this case a drug-eluting stent - is another common item implanted in humans. ... Applications. Implants can roughly be categorized into groups by application: Sensory and neurological. Sensory and ... Some implants are bioactive, such as subcutaneous drug delivery devices in the form of implantable pills or drug-eluting stents ... 8] The application of this device is being tested an alternative to medicating sufferers of rheumatoid arthritis for their ...
ICD-9-CM Volume 3
Insertion of non-drug-eluting peripheral vessel stent(s) (39.91) Freeing of vessel (39.92) Injection of sclerosing agent into ... Application of neck support Application of cervical collar Application of Minerva jacket (93.6) Osteopathic manipulative ... Application of external fixator device (78.2) Limb shortening procedures (78.3) Limb lengthening procedures (78.4) Other repair ... Application of orthodontic appliance (24.8) Other orthodontic operation (24.9) Other dental operations (25) Operations on ...
... then documented in pigs and recently confirmed by others in humans by the prevention of restenosis with drug-eluted stents. The ... Established and Emerging Applications [Hardcover] Albert Lardo (Author), Zahi Fayad (Author), Nicolas Chronos (Author), ... "Bypass surgery significantly better than stents for treating multiple blockages in diabetics" (Press release). Heart.org. ... The striking benefit of surgical revascularization versus stenting represents unique breakthroughs in the cardiovascular field ...
Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall procedure. *Valve-sparing aortic root replacement ... The most common application of cryoablation is to ablate solid tumors found in the lung, liver, breast, kidney and prostate. ... has been playing a leading role in the world in terms of both theoretical research and clinical application of cryotherapy. As ...
Cardiac magnetic resonance imaging
Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall procedure. *Valve-sparing aortic root replacement ... The clinical application of RFA in obstructive sleep apnea is reviewed in that main article, including controversies and ... tumescent anesthesia injected along the entire vein prior to the application of radiofrequency provide a heat sink that absorbs ...
Artificial cardiac pacemaker
Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall procedure. *Valve-sparing aortic root replacement ... If hair is present at the surgical site, it is clipped off prior to prep application. The patient is assisted by an ... In addition, the discovery of muscle relaxants such as curare allowed for safer applications. ...
Coronary stent. Bare-metal stent. Drug-eluting stent. *Bentall procedure. *Valve-sparing aortic root replacement ... Americans can learn Hands-Only CPR with a new digital application Archived 2011-07-17 at the Wayback Machine ... the Red Cross updated and endorsed its emergency preparedness application, which uses pictures, text and videos to assist the ... potential for incorrect application and the need for multiple device sizes. ...
Clinical application of cardiac catheterization begins with Werner Forssmann in 1929, who inserted a catheter into the vein of ... If necessary, the physician can utilize percutaneous coronary intervention techniques, including the use of a stent (either ... bare-metal or drug-eluting) to open the blocked vessel and restore appropriate blood flow. In general, occlusions greater than ... Percutaneous coronary intervention, however, involves the use of mechanical stents to increase blood flow to previously blocked ...
Abbott Submits Application for Approval of XIENCE V Everolimus Eluting Coronary Stent System
Abbott announced that it has submitted an application forSeizo Hanbai Shonin (Marketing Authorization License) to Japans ... Home Industry Updates Press Releases Abbott Submits Application for Approval of XIENCE V Everolimus Eluting Coronary Stent... ... Abbott Submits Application for Approval of XIENCE V Everolimus Eluting Coronary Stent System. 358 ... the first head-to-head clinical trial to demonstrate the superiority of one drug eluting stent over another drug eluting stent ...
In vitro and in vivo degradation of rapamycin-eluting Mg-Nd-Zn-Zr alloy stents in porcine coronary arteries. | AMERICAN...
... for both in vitro and in vivo investigation of the degradation behaviors of the magnesium alloy stent platform. Electrochemical ... rapamycin-eluting poly (d, l-lactic acid) coating (PDLLA/RAPA) was prepared on biodegradable Mg-Nd-Zn-Zr alloy (JDBM) ... Products by Application. Additive Manufacturing & 3D Printing Battery & Supercapacitor Materials Biomaterials CatalystsDental ... In vitro and in vivo degradation of rapamycin-eluting Mg-Nd-Zn-Zr alloy stents in porcine coronary arteries. Mater Sci Eng C ...
Patent US8128687 - Drug-eluting stent with filament strands - Google Patents
The stent has a high degree of flexibility in the longitudinal direction, yet has adequate vessel wall coverage and radial ... The polymeric sleeve is attached to at least a portion of an outside surface area of the stent structure. Alternatively, a ... An intravascular stent having a prefabricated, patterned polymeric sleeve for controlled release of therapeutic drugs and for ... plurality of individual microfilament strands are longitudinally attached to an outer surface of a stent structure in a spaced ...
Patent US8252048 - Drug eluting stent and method of making the same - Google Patents
... the intermediate layer eluting drug in a lateral direction, and methods of making the same. ... A drug eluting stent comprising a multilayer tubular structure which includes at least one intermediate layer having reservoirs ... in a stent which, elutes drugs from selected portions of the stent structure. Such selective application of the porous ... A stent designed for the release of a drug, the stent comprising a tubular structure and a stent wall, the stent wall having an ...
Patent US7951193 - Drug-eluting stent - Google Patents
A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each ... Porous metallic stent with a ceramic coating. EP1348402A1. 29 Mar 2002. 1 Oct 2003. Advanced Laser Applications Holding S.A.. ... Stent with thin drug-eluting film. EP1886703B1. 10 Jul 2007. 23 Jun 2010. BIOTRONIK VI Patent AG. Stent with a coating ... Modified stent useful for delivery of drugs along stent strut. US20050137684. 13 Dec 2004. 23 Jun 2005. Pfizer Inc. Stent with ...
US7048927B2 - Botulinum neurotoxin eluting stent - Google Patents
Botulinum neurotoxin eluting stent Expired - Fee Related US7048927B2 (en) Priority Applications (3). Application Number. ... US7048927B2 - Botulinum neurotoxin eluting stent - Google Patents. Botulinum neurotoxin eluting stent Download PDF Info. ... In one embodiment, these compositions include a stent with a botulinum toxin attached to the stent or imbedded in the stent. ... Botulinum neurotoxin eluting stent US10870603 Expired - Fee Related US7494654B2 (en) 1999-08-10. 2004-06-16. Compositions and ...
US20060195142A1 - Micromantled drug-eluting stent - Google Patents
... drug-eluting stent are formed of a primary expandable polymeric or metallic construct, intimately mantled with a ... selected from those expected to control key biological events leading to in-stent restenosis. ... Micromantled drug-eluting stent Active 2020-11-18 US7416559B2 (en) Priority Applications (4). Application Number. Priority Date ... US20060195142A1 - Micromantled drug-eluting stent - Google Patents. Micromantled drug-eluting stent Download PDF Info. ...
Drug Eluting Stents (DES) Market increasing demand in Global Countries | Industry Professionals: Biosensors, Essen, Orbusneich ...
HTF MI published a new industry research that focuses on Drug Eluting Stents (DES) market and delivers in-depth market analysis ... Specifications and Classification of Drug Eluting Stents (DES), Applications of Drug Eluting Stents (DES), Market Segment by ... Magnesium alloy Stents, Tyrosine polycarbonate Stents, Nitinol Stents, Platinum chromium alloy Stents, Stainless steel Stents ... Magnesium alloy Stents, Tyrosine polycarbonate Stents, Nitinol Stents, Platinum chromium alloy Stents, Stainless steel Stents ...
OrbusNeich COMBO Drug Eluting Stent with Endothelial Progenitor Cell Capture | Medgadget
Drug eluting stents have become commonplace, but they effectively slow down healing and endothelium formation in exchange for ... Biotechnology and its Applications. • Biopharmaceutical Engineering. • Chemical Biotechnology. • Biomass and Bioenergy. • ... the in-stent late lumen loss for the COMBO Stent was 0.39 +/- 0.45 mm compared to 0.44 +/- 0.56 mm for the control drug eluting ... for the drug eluting stent group; the clinically driven target lesion revascularization (TLR) rate was 4.9% for the COMBO Stent ...
Development of Hydrophobized Alginate Hydrogels for the Vessel-Simulating Flow-Through Cell and Their Usage for Biorelevant...
... has been used to examine release and distribution from drug-eluting stents in an in vitro model adapted to the stent placement ... Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003;349( ... Hydrogels for biomedical applications. Ann N Y Acad Sci. 2001;944(1):62-73. doi: 10.1111/j.1749-6632.2001.tb03823.x.PubMed ... A randomized comparison of a sirolimus-eluting stent with a standard stent for coronary revascularization. N Engl J Med. 2002; ...
Drug-Eluting Stents: Design for Prevention of Angioplastic Restenosis
application/pdf. dc.language.iso. en_US. dc.subject. Angioplastic. en_US. ... Drug-Eluting Stents: Design for Prevention of Angioplastic Restenosis. dc.contributor.author. Chen, Bonnie. ... The stent geometry was reduced to six concentric rings of 1.5 mm width spaced 1.5 mm apart, resulting in a total stent length ... Recent advancements have led to the development of drug-eluting stents designed to release a drug polymer that inhibits ...
GM viruses can treat brain tumors; Drug-eluting stent market to hit $6B by 2015; | FiercePharma
Drug delivery patent application of the week: Compositions and methods for controlled delivery of inhibitory ribonucleic acids ... The global market for drug-eluting stents is expected to reach $6 billion by 2015, according to a new report. Report ... GM viruses can treat brain tumors; Drug-eluting stent market to hit $6B by 2015; ...
Flat process of preparing drug eluting stents - Patent application
13. A method of filling reservoirs of a drug eluting stent comprising: providing a flat stent pattern, wherein said stent ... Drug eluting stent system and manufacturing process of drug eluting stent system. ... Patent application title: Flat process of preparing drug eluting stents. Inventors: Jacob Richter (Arsuf, IL) Assignees: ... CROSS REFERENCE TO RELATED APPLICATIONS  This application claims benefit of priority of provisional application No. 61/ ...
Drug-Eluting Stents: Innovative Devices Fill Pipeline | Medpage Today
Despite the sturm and drang over the thrombosis threats posed by the two first generation drug-eluting coronary stents, there ... Its application was based on the required three-month safety and efficacy data. ... Kuntz, and makers of other investigational drug-eluting stents, contended that stent thrombosis was not "a class-effect issue ... In place of a registry of all drug-eluting stent patients, Dr. Topol proposed a narrower national registry of patients who have ...
FDA Approves Drug-Eluting Stent for Clogged Heart Arteries | FierceBiotech
Food and Drug Administration today approved the Endeavor Zotarolimus-Eluting Coronary Stent for use in treating patients with ... FDA Approves Drug-Eluting Stent for Clogged Heart Arteries The U.S. ... Medtronic provided data from seven clinical trials in its marketing application. Studies showed that the Endeavor significantly ... Endeavor stent was similar to those that occurred in patients implanted with bare-metal stents and existing drug-eluting stents ...
"Laser texturing of drug eluting stents to improve drug adhesion" by Michelle Kay Buehler
This study investigates the potential to eliminate the polymer on drug eluting stents to decrease the chance of the requirement ... Drug elution trials proved that laser texturing of metallic stents offers steadier release rates and better drug adhesion than ... Nanosecond laser texturing of metallic stent surfaces generates laser-induced periodic surface structures, also referred to as ... Surface profilometer results demonstrated that laser texturing significantly improves surface topography over bare metal stents ...
Peripheral Drug-Eluting Stents Market 2019 Global Industry Growth Analysis, Segmentation, Size, Share, Trend, Future Demand and...
The Global Peripheral Drug-Eluting Stents to gain from rapid technological advancements taking place in the market. Recently ... Europe Peripheral Drug-Eluting Stents Analysis, Insights and Forecast, 2014-2025. *Asia Pacific Peripheral Drug-Eluting Stents ... Global Peripheral Drug-Eluting Stents Analysis, Insights and Forecast, 2014-2025. *North America Peripheral Drug-Eluting Stents ... title Peripheral Drug-Eluting Stents Size, Share and Global Trend by Peripheral Drug-Eluting Stents Market Size, Share and ...
Drug-Eluting Stent Update 2007 | Circulation
Bench to bedside: the development of rapamycin and its application to stent restenosis. Circulation. 2001; 104: 852-855. ... Drug-Eluting Stent Update 2007. Part I: A Survey of Current and Future Generation Drug-Eluting Stents: Meaningful Advances or ... Although only sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) have received US Food and Drug Administration ... Two-Year clinical follow-up of the unrestricted use of the paclitaxel-eluting stent compared to the sirolimus-eluting stent as ...
Rapamycin eluting stent: the onset of a new era in interventional cardiology | Heart
The first clinical application of the rapamycin coated stent was performed in Sao Paulo and Rotterdam. Thirty patients with ... THE RAPAMYCIN ELUTING STENT. The rapamycin coated BX Velocity stent is fabricated from medical 316 LS stainless steel. It is ... with rapamycin eluting stents occur in a similar temporal sequence as observed with bare metal stents. The focal remnants of ... and the advent of the stent (Palmaz-Schatz, Wallstent). The drug eluting stent is the third such development, and almost one ...
Abbott Submits XIENCE V Everolimus Eluting Coronary Stent System Application for FDA Approval | DAIC
Eluting Coronary Stent System with the MULTI-LINK VISION® metallic. stent system. SPIRIT FIRST met its primary endpoint and ... Abbott Submits XIENCE V Everolimus Eluting Coronary Stent System Application for FDA Approval. ... "As history unfolds in drug-eluting stent treatment, it has become apparent that there is a critical need for new, next- ... In-stent late loss is a measure of vessel re-narrowing along the length of the stent.. -- SPIRIT III, a large-scale, randomized ...
Angiotech Announces That Cook Medical's Zilver Ptx Drug-Eluting Stent Meets Its Primary Endpoint In A 479-Patient, Multi-Center...
... are optimistic that this study will support Cooks application with the FDA to become the first drug eluting peripheral stent ... Home › News › Clinical Trials › Angiotech Announces That Cook Medicals Zilver Ptx Drug-Eluting Stent Meets Its Primary ... It is the first drug-eluting stent indicated for treating PAD in the SFA, an often difficult-to-treat blood vessel in the leg. ... In the United States, the Zilver PTX Drug-Eluting Stent is an investigational device not available for sale at this time. ...
Drug Eluting Stents for Malignant Airway Obstruction: A Critical Review of the Literature
Clinical application of airway bypass with paclitaxel-eluting stents: early results. The Journal of thoracic and cardiovascular ... In-stent restenosis is inhibited in a bare metal stent implanted distal to a sirolimus-eluting stent to treat a long de novo ... Comparison of zotarolimus-eluting stent and everolimus-eluting stent for vascular healing response: serial 3-month and 12-month ... Comparison of paclitaxel-eluting stents (Taxus) and everolimus-eluting stents (Xience) in left main coronary artery disease ...
Modelling chemistry and biology after implantation of a drug-eluting stent. Part Ⅱ: Cell proliferation
The aim of a drug eluting stent is to prevent restenosis of arteries following percutaneous balloon angioplasty. A long term ... goal of research in this area is to use modelling to optimise the design of these stents to maximise their efficiency. A key ... Mathematics Applications Consortium for Science and Industry, University of Limerick, Castletroy, Co. Limerick, Ireland ... W. Khan, S. Farah and A. J. Domb, Drug eluting stents: developments and current status, Journal of Controlled Release, 161 ( ...
Applications brief: Preparation of paclitaxel/chitosan co-assembled core-shell nanofibers for drug-eluting stent
... October 24, ... the hydrophilic and flexible properties of NFs make them easily coating and filming on stent to prepare drug-eluting stent (DES ... co-assembly , paclitaxel , chitosan , core-shell nanofibers , drug-eluting stent , nanoIR. Authors. J. Tanga, Y. Liua, B. Zhu, ... are easily prepared by co-assembly of PTX and CS and used in drug-eluting stent. The mixture solution of PTX (dissolved in ...
Role of Second-Generation Drug-Eluting Stents and Bypass Grafting...: Ingenta Connect
Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW- ... everolimus-eluting stents; second-generation drug-eluting stents; zotarolimus-eluting stents ... Background: The safety and efficacy of coronary artery bypass grafting (CABG) and second-generation drug-eluting stents (DESs) ... Role of Second-Generation Drug-Eluting Stents and Bypass Grafting in Coronary Artery Disease: A Systematic Review and Meta- ...
Chromium News, Research
New insights into application of drug-eluting stents during percutaneous coronary intervention Researchers at the Thorax ... and the University of Twente have recently completed their fourth major study into the application of drug-eluting stents ... Clinical study shows efficacy, safety of novel drug-eluting stent with improved radiographic visibility This first randomized ... The PK Papyrus Covered Coronary Stent System is the first device approved by the FDA for this indication in 17 years. ...
Drug Eluting Stent News, Research
A tablet computer application helped heart patients with drug-eluting stents take their medications correctly, a study has ... Drug Eluting Stent News and Research. RSS A drug-eluting stent (DES) is a coronary stent (a scaffold) placed into narrowed, ... The first randomized trial to compare a durable polymer drug-eluting stent to a polymer-free drug-coated stent in patients at ... It is the first 5 mm drug-eluting stent in the U.S. with lengths available up to 140 mm that is indicated to treat vessels as ...
Harvey L. Berger - Wikipedia
... such as medical applications and more specifically the coating of drug-eluting stents. Strutt, John William (1945). The Theory ... "Using Ultrasonic Spray Nozzles to Coat Drug-Eluting Stents". Notes Berger, Harvey L. Ultrasonic Liquid Atomization: Theory and ... drug eluting stents and spray drying. Berger died in August 2007 after a struggle with liver cancer. He was survived by his ... Theory and Application in 1998. Being the father of the application of the technology, Harvey Berger was frequently called to ...
Durable Drug Eluting Stents Market Analysis with Global Market Size, Industry Share, trends and Forecast to 2026:Research...
To examine and forecast the global Durable Drug Eluting Stents market on the basis of types, explications, and applications. To ... This report examines the Durable Drug Eluting Stents market by the following segments:. *Durable Drug Eluting Stents Market, by ... application and five major geographical regions. Global Durable Drug Eluting Stents market is supposed to witness a high ... Press Release October 29, 2018 , by charliegefen Comments Off on Durable Drug Eluting Stents Market Analysis with Global Market ...
Current and Future State of Drug-Eluting Stents
Boam of the FDA provide a comprehensive overview of drug-eluting stents, including the state of current approvals and future ... Could you give us an overview of what kind of data the FDA are looking for in an application of a new DES? ... Stent thrombosis didnt originate with DES. Acute stent thrombosis, meaning stent thrombosis within the first 30 days, was an ... Ashley B. Boam, BSE, MSBE: Welcome to this Medscape expert commentary on drug-eluting stents (DES). Im Ashley Boam, Chief of ...
ImplantationImplanted with bare-metal stentsSirolimus-elutin2018Second-generation drug-elutinZilver PTX Drug-ElutiGlobal drug-elutiPolymer-freeCapped the prices of coronary stentsTaxusEverolimus-elutinLate lumen loss2019AngioplastyScaffoldsMedtronicBiodegradable stentsCardiovascularMetallic stentMyocardial infarctionPrimary endpointNeointimal hyperplasiaExpandable2017ArterialLumenMarketCoatingsForecast
- The XIENCE V stent utilizes everolimus, which has been shown to reduce tissue proliferation in the coronary vessels following stent implantation, and is built upon Abbott's MULTI-LINK VISION® Coronary Stent System, the world's market-leading bare metal stent. (hhmglobal.com)
- A comparison of balloon-expandable-stent implantation with balloon angioplasty in patients with coronary artery disease. (springer.com)
- Based on recent concerns over the rare but serious side effect of blood clots or stent thrombosis, FDA asked Medtronic to combine data from all Endeavor trials to determine how often this happened at various points in time following stent implantation. (fiercebiotech.com)
- Modelling chemistry and biology after implantation of a drug-eluting stent. (aimsciences.org)
- that is, does the coating remain in place on the metallic stent or are small particles released downstream as the stent travels through the arteries to the implantation site? (medscape.com)
- We also ask for a smaller subset of patients with protocol-mandated angiography and intravascular ultrasound to assess healing responses and how well the stent is apposed to the artery wall, both immediately post-implantation and in the long term. (medscape.com)
- Long-term follow-up evaluation after sirolimus-eluting stent implantation by optical coherence tomography: do uncovered struts persist? (semanticscholar.org)
- s w t o t n t b w o the Editor: Presently, occurrence of late stent thrombosis (LST) fter drug-eluting stent implantation is a major clinical concern. (semanticscholar.org)
- A long-term follow-up study revealed recently that ST occurs at a constant rate of 0.6%/year for up to 3 years after rug-eluting stent implantation (1). (semanticscholar.org)
- Evaluation of neointimal coverage and apposition with various drug-eluting stents over 12 months after implantation by optical coherence tomography. (semanticscholar.org)
- Evaluation by optical coherence tomography of neointimal coverage of sirolimus-eluting stent three months after implantation. (semanticscholar.org)
- Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits. (springermedizin.at)
- The Ultimaster TANSEI DES will be a core component of the currently enrolling MASTER DAPT study, which compares an abbreviated versus prolonged DAPT within current guidelines and instructions for use, following stent implantation in patients presenting with high bleeding risk (HBR) features. (terumo-europe.com)
- Objective To compare the application effect and cost in intracoronary stent implantation between domestic and imported drug eluting stent. (cnki.com.cn)
- Methods A total of 791 coronary heart disease patients undergoing intracoronary stent implantation were selected in a Grade 3 and first-class hospital in 2013,and they were divided into A group( using domestic drug eluting stent,n = 398) and B group( using imported drug eluting stent,n = 393) according to the types of stents. (cnki.com.cn)
- During the intracoronary stent implantation,patients of A group used Shanghai Minimally-invasive Firebird Ⅱ Drug-eluting Stents,while patients of B group received United States Medtronic Endenvor Drug Eluting Stents. (cnki.com.cn)
- Conclusion Domestic and imported drug eluting stent have similar application effect on intracoronary stent implantation,but using domestic drug eluting stent can significantly reduce the medical expenses. (cnki.com.cn)
- The near elimination of stent thrombosis observed between one and four years after implantation shows that everolimus-eluting stents overcome the principal limitation of early generation DES," said investigator Dr Lorenz Räber from the University Hospital of Bern, Switzerland. (healthcanal.com)
- Stent thrombosis occurring more than one year after implantation - commonly referred to as very late stent thrombosis (VLST) - has been observed more frequently in patients treated with early generation DES releasing the drugs paclitaxel or sirolimus than with bare metal stents and has emerged as a distinct entity complicating their use. (healthcanal.com)
- The procedure was completed successfully, including implantation of two drug-eluting stents. (kurzweilai.net)
- Objectives The authors sought to investigate the association between P2Y 12 reaction units (PRU) and the risk of ischemic stroke (IS) after successful coronary drug-eluting stents (DES) implantation. (onlinejacc.org)
- Ein Modell der Stent-Implantation in Maus Halsschlagader beschrieben. (jove.com)
- Assessment of vascular wall responses, including volumetric measurements of vessel, stent, lumen, peri-stent plaque, and intimal hyperplasia, indices of remodeling, stent expansion, and stent-vessel wall apposition in response to biolimus-eluting and bare-metal stent implantation will be performed. (clinicaltrials.gov)
- Since the balloon is immediately deflated after maximal inflation during stent implantation and 80% of the expandable wire mesh of the stent was open surface opposing elastic recoil, the process minimized endothelial damage compared to balloon angioplasty alone [ 5 ]. (mdpi.com)
- It is hoped that gene therapy will be less expensive and affordable because the techniques involved are simpler than those involved in cardiac bypass surgery, heart transplantation and stent implantation. (prnewswire.com)
Implanted with bare-metal stents1
- Tissue coverage of paclitaxel and sirolimus eluting stents in long term follow-up: optical coherence tomography study. (semanticscholar.org)
- The reduction in stent thrombosis was most prominent between one and four years, resulting in a 67% risk reduction in VLST for the comparison of everolimus-eluting with sirolimus-eluting stents, and a 76 % risk reduction for the comparison of everolimus-eluting with paclitaxel-eluting stents. (healthcanal.com)
- Additionally, increasing per capita income and rising living standards is expected to drive the global Peripheral Drug-Eluting Stents during the forecast period 2018-2025. (globalbankingandfinance.com)
- A removable balloon is as good as a permanent stent implant for opening small blocked arteries, according to late breaking results from the BASKET-SMALL 2 trial presented in a Hot Line Session today at ESC Congress 2018 and simultaneously published in The Lancet. (news-medical.net)
- Long-term antiplatelet monotherapy after stenting is safe but does not reduce the risk of death or heart attack compared to standard dual antiplatelet therapy, according to late breaking results from the GLOBAL LEADERS trial presented today in a Hot Line Session at ESC Congress 2018 and published in The Lancet. (news-medical.net)
- The global market size of Coronary Stent is $XX million in 2018 with XX CAGR from 2014 to 2018, and it is expected to reach $XX million by the end of 2024 with a CAGR of XX% from 2019 to 2024. (aarkstore.com)
- The minutes of meeting state: "The Authority deliberated and decided that the NPPA, in any case, shall revisit the pricing of cardiac stents before February 13, 2018. (indianexpress.com)
Zilver PTX Drug-Eluti3
- In the United States, the Zilver PTX Drug-Eluting Stent is an investigational device not available for sale at this time. (drugs.com)
- We're excited to present the data on Cook Medical's Zilver PTX Drug-Eluting Stent. (cookmedical.com)
- FDA Panel will discuss, make recommendations and vote on information related to the premarket approval application (PMA) for the Zilver PTX Drug-Eluting Stent. (cookmedical.com)
- Europe, Middle East & Africa, Asia-Pacific and Americas are having significant growth in global drug-eluting stent market over the past decade and also it is expected to increase its dominance over the forecast period at a CAGR of 5.36% over the (2019-2025) forecast period. (oganalysis.com)
- Global Drug-eluting stent report provides strategic analysis of the Market through key drivers, restraints, challenges and opportunities. (oganalysis.com)
- The research work categorizes the Global Drug eluting stent Market based on product into 2 categories including Polymer Based Coating, Polymer Free Coating. (oganalysis.com)
- The first randomized trial to compare a durable polymer drug-eluting stent to a polymer-free drug-coated stent in patients at high risk of bleeding and treated with one-month dual antiplatelet therapy (DAPT) found that both are clinically safe and effective. (news-medical.net)
- The demand for polymer-free drug eluting stents is going to increase considerably with new products entering the market, especially in emerging countries such as Brazil, Mexico, and South Africa. (giiresearch.com)
- VANCOUVER , June 11 /CNW/ - Angiotech Pharmaceuticals, Inc. (NASDAQ: ANPI, TSX: ANP) today announced Cook Medical, a license holder of Angiotech's paclitaxel technology, has submitted its Pre-Market Approval (PMA) application to the U.S. Food and Drug Administration (FDA) for the company's unique polymer-free Zilver(R) PTX(R) Drug-Eluting Peripheral Stent. (newswire.ca)
Capped the prices of coronary stents1
- It is against this background that newer generation DES, such as everolimus-eluting stents, have been developed, to improve safety with the application of a more biocompatible polymer, along with a reduction in drug dose and reduced strut thickness. (healthcanal.com)
- mean age 72.8±7.2 years) who had previously received 21 infrapopliteal sirolimus- or everolimus-eluting stents. (octnews.org)
Late lumen loss2
- Further, the research report presents near term and long term forecast of the global drug eluting stents during the forecast period 2019-2025. (oganalysis.com)
- Global Coronary Stent Market Report 2019 - Market Size, Share, Price, Trend and Forecast is a professional and in-depth study on the current state of the global Coronary Stent industry. (aarkstore.com)
- 5.The report estimates 2019-2024 market development trends of Coronary Stent industry. (aarkstore.com)
- In the Drug-Eluting Balloons statistical surveying study, 2019 is considered as the base year, and 2020-2027 is considered as the estimate time frame to anticipate the market size. (galusaustralis.com)
- The Drug-Eluting Balloons market clicked an estimation of ~US$ xx Mn/Bn in 2019. (galusaustralis.com)
- Endpoints included event-free survival (EFS), stent integrity by radiographic core laboratory analysis and primary patency by Duplex ultrasound core laboratory analysis (peak systolic velocity ratio 55 institutions in the United States, Japan and Germany, with 241 patients randomized to the Zilver PTX group and 238 to the balloon angioplasty group. (drugs.com)
- Approximately half the balloon angioplasty group experienced acute failure and underwent secondary randomization, assigning 59 and 61 patients to provisional stenting with Zilver BMS and Zilver PTX, respectively. (drugs.com)
- Deployment of a stent overcomes some limitations of balloon angioplasty alone, but provides an acute stimulus for thrombus formation and promotes neointimal hyperplasia. (mdpi.com)
- Patients with heart disease commonly receive such stents, narrow metal scaffolds that widen a partly clogged blood vessel. (redorbit.com)
- The National Pharmaceutical Pricing Authority (NPPA) had in February slashed the prices of coronary stents by over 80% and set ceilings for all drug-eluting stents and bioresorbable vascular scaffolds (BVS). (livemint.com)
- Improved results were observed following the insertion of an additional intravascular mechanical support, cylindrical metal scaffolds known as stents [ 5 ]. (mdpi.com)
- For example, the Endeavor stent from Medtronic was submitted for FDA approval last Nov. 16. (medpagetoday.com)
- Manufactured by Medtronic, Inc., of Minneapolis, the device is a tiny metal mesh tube coated with a small amount of a new drug, zotarolimus, developed only for use on a stent. (fiercebiotech.com)
- GAITHERSBURG, Md., Oct. 11 -- An FDA advisory panel voted unanimously to recommend approval of a zotarolimus-eluting coronary stent made by Medtronic. (medpagetoday.com)
- MINNEAPOLIS Oct. 11, 2005 Medtronic ( NYSE: MDT ) announced that it has submitted its first Pre-Market Approval (PMA) module to the U.S. Food and Drug Administration for the Endeavor Drug-Eluting Coronary Stent system. (webwire.com)
- This action represents the first step by Medtronic in the U.S. approval process for Endeavor stents. (webwire.com)
- Scott Ward, president of Medtronic Vascular in Santa Rosa, Calif., said the company has worked diligently with the FDA to develop a well-designed schedule of modular submissions that meet the agency s requirements for the Endeavor stent and the new molecular entity, ABT-578. (webwire.com)
- The NPPA did not put a separate price cap for biodegradable stents as requested by multinational companies such as India Medtronic, Abbott Healthcare and Boston Scientific India. (indianexpress.com)
- Another stent maker, Medtronic, had also sought to withdraw its Onyx Zotarolimus eluting stents but the NPPA rejected its application. (livemint.com)
- The increasing adoption of biodegradable stents is mainly driving the growth of the polymer-based coating stents segment. (giiresearch.com)
- Technological advancements, such as the introduction of biodegradable stents primarily, led to the highest revenue generation in the region. (giiresearch.com)
- However, the sub-committee has opined that no information/evidence/data has been generated which changes the opinion and, therefore, the sub-committee reiterated its earlier recommendation and did not agree to exclude bioabsorbable vascular scaffold/biodegradable stents from the two categories of stents currently under price control. (indianexpress.com)
- Consequently, companies such as Boston Scientific India and Abbott Healthcare have requested the NPPA to let them withdraw their latest-generation stents, which include biodegradable stents, from the Indian market. (indianexpress.com)
- As history unfolds in drug-eluting stent treatment, it has become apparent that there is a critical need for new, next-generation platforms with the potential to improve patient care," said Gregg W. Stone, M.D., of Columbia University Medical Center and the Cardiovascular Research Foundation, New York, and principal investigator in the SPIRIT II and III trials. (dicardiology.com)
- Cardiovascular Innovations and Applications is the official journal of the Great Wall International Congress of Cardiology (GW-ICC). (ingentaconnect.com)
- For physicians, surgeons, and scientists working on cardiovascular disorders, Applications of Biotechnology in Cardiovascular Therapeutics serves as an invaluable reference by collecting the essential writings of Dr. Kewal K. Jain on the topics of biotechnology as they relate to cardiovascular disease. (springer.com)
- Comprehensive and up-to-date, Applications of Biotechnology in Cardiovascular Therapeutics will be tremendously useful for those working in life sciences and the pharmaceutical sciences, and the inclusion of some basics of cardiovascular diseases will greatly benefit nonmedical readers as well. (springer.com)
- Growing incidence of cardiovascular diseases, increasing geriatric population and acceptance for minimally invasive endovascular surgeries are the factors striving the growth of Drug-eluting stents market. (oganalysis.com)
- 2. The method of claim 1, wherein a non-toxic chemical route in alkaline conditions at varying temperature and time yields distinct nanostructural features of tunable morphologies on the surface of endovascular prosthesis for improved cardiovascular applications. (google.es)
- A publication of results of a research study in one of the nation's most respected medical journals, which examined the performance of drug-coated stents in cardiovascular disease patients, recently reported in the Journal of the American Medical Association (JAMA), confirmed findings of prior research indicating that commonly used drug-coated stents cause a much higher rate of complications and death than previously thought. (chron.com)
- This illustrates the need for further innovation and research in the stent arena and opens the competitive door for companies like MIV Therapeutics (OTCBB:MIVT), a leading developer of next-generation biocompatible coatings and advanced drug delivery systems for cardiovascular stents and other implantable medical devices," Clark added. (chron.com)
- Its products find applications in various therapeutic areas such as cardiovascular, peripheral vascular, neurovascular and structural heart disease. (bioportfolio.com)
- The material's thermo-mechanical characteristics and its biocompatibility make it ideal for cardiovascular stents, endoscopic instruments, surgical tools and other products. (assemblymag.com)
- Most people associate nitinol with cardiovascular stents. (assemblymag.com)
- Nanosecond laser texturing of metallic stent surfaces generates laser-induced periodic surface structures, also referred to as ripples, which can be utilized to promote drug adherence directly to the stent surface. (iastate.edu)
- Eluting Coronary Stent System with the MULTI-LINK VISION® metallic stent system. (dicardiology.com)
- Data from the EVOLVE Short DAPT study found that shortened three-month dual antiplatelet therapy did not increase myocardial infarction or stent thrombosis in high bleeding risk patients treated with a contemporary drug-eluting stent. (news-medical.net)
- These studies usually involve evaluation of a composite primary endpoint of cardiac death, myocardial infarction, and need for repeat procedure involving the lesion where the stent was placed. (medscape.com)
- A five-year, 5,000-patient post-marketing study with a primary endpoint of very late stent thrombosis and a secondary endpoint of death and/or myocardial infarction. (medpagetoday.com)
- Patients treated with CABG had lower rates of death and of death or myocardial infarction than treatment with a drug-eluting stent. (wikipedia.org)
- Although rare, stent thrombosis is a serious complication, which may result in death or acute myocardial infarction. (healthcanal.com)
- the safety of HIT in acute myocardial infarction patients with drug-eluting stent. (scribd.com)
- Conclusions: HIT is more effective than MCT for improving VO2peak in acute myocardial infarction patients with drug-eluting stent. (scribd.com)
- Treatment of patients with acute myocardial infarction with drug eluting stents (DES) is effective but there remain concerns regarding the long-term safety and adverse effects on the adjacent arterial wall. (clinicaltrials.gov)
- Novel nanocomposite stent coating releasing resveratrol and quercetin reduces neointimal hyperplasia and promotes re-endothelialization. (springer.com)
- Delayed neointimal growth, enhanced platelet aggregation, a local hypersensitivity reaction against the polymer coating, stent fracture, and a failure of sirolimus-, paclitaxel-, and tacrolimus-eluting stents to reduce neointimal hyperplasia at 90 and 180 days in animals, when the drug was completely eluted from the stent, are just several examples. (ahajournals.org)
- Stents and similar devices such as stent, stent-grafts, expandable frameworks, and similar implantable medical devices, are radially expandable endoprostheses which are typically intravascular implants capable of being implanted transluminally and enlarged radially after being introduced percutaneously. (google.com.au)
- There are wide varieties which is employed various purposes such as in biliary and vascular stents and expandable coronary, and in simple plastic stents which is used for allowing urine to flow easily between the bladder and the kidney. (qyresearchreports.com)
- Stents are expandable wire-mesh devices placed in clogged blood vessels to prop open the vessels to maintain healthy blood flow to the heart or elsewhere in the body," stated SmallCap Sentinel analyst D.R. Clark . (chron.com)
- The first balloon expandable stents were designed from surgical grade stainless steel, and aimed to provide additional mechanical support, limiting vessel recoil and preventing acute occlusion [ 6 ]. (mdpi.com)
- F. Bozsak , J. M. Chomaz and A. I. Barakat , Modeling the transport of drugs eluted from stents: Physical phenomena driving drug distribution in the arterial wall, Biomechanics and Modeling in Mechanobiology , 13 (2014), 327-347. (aimsciences.org)
- Extensive application of coronary intravascular procedures has led to the increased need of understanding the injury inflicted to the coronary arterial wall. (eur.nl)
- The magnetic field, comparable to that produced by existing MRI machines, but one-tenth as strong, magnetized both the stents and the nanoparticles, and drove the particles into the stents and the nearby arterial tissue. (redorbit.com)
- Over the past several years, Levy and colleagues have shown similar proofs of concept in other animal studies, using magnetically guided nanoparticles to deliver gene therapy and therapeutic endothelial cells to arterial stents. (redorbit.com)
- A stent for delivering therapeutic agents to a body lumen includes a plurality of circumferential serpentine bands with each band comprising a plurality of struts. (google.com.au)
- A stent is a medical device introduced to a body lumen and is well known in the art. (google.com.au)
- Drug eluting stents have become commonplace, but they effectively slow down healing and endothelium formation in exchange for an open lumen through which blood can flow with little interference. (medgadget.com)
- The angiographic analysis from the SCRIPPS (Scripps coronary radiation to inhibit proliferation post-stenting) trial at three years showed a reduction of the minimum lumen diameter in irradiated patients but not in the placebo group, 11 with a further increase in target lesion revascularisation (TLR) between 3-5 years in the irradiated patients only. (bmj.com)
- HTF MI published a new industry research that focuses on Drug Eluting Stents (DES) market and delivers in-depth market analysis and future prospects of Global Drug Eluting Stents (DES) market. (medgadget.com)
- The research covers the current market size of the Global Drug Eluting Stents (DES) market and its growth rates based on 5 year history data along with company profile of key players/manufacturers. (medgadget.com)
- The in-depth information by segments of Drug Eluting Stents (DES) market helps monitor future profitability & to make critical decisions for growth. (medgadget.com)
- The information on trends and developments, focuses on markets and materials, capacities, technologies, CAPEX cycle and the changing structure of the Global Drug Eluting Stents (DES) Market. (medgadget.com)
- The market is growing at a very rapid pace and with rise in technological innovation, competition and M&A activities in the industry many local and regional vendors are offering specific application products for varied end-users. (medgadget.com)
- Global Drug Eluting Stents (DES) (Thousands Units) and Revenue (Million USD) Market Split by Product Type such as Cobalt-chromium alloy Stents, Magnesium alloy Stents, Tyrosine polycarbonate Stents, Nitinol Stents, Platinum chromium alloy Stents, Stainless steel Stents & Other Materials. (medgadget.com)
- Following would be the Chapters to display the Global Drug Eluting Stents (DES) market. (medgadget.com)
- The global market for drug-eluting stents is expected to reach $6 billion by 2015, according to a new report. (fiercepharma.com)
- This number has dropped to 10 percent of patients since drug-eluting stents entered the U.S. market in 2003. (fiercebiotech.com)
- Analyst projections for the drug-eluting stent (DES) market estimated that the total number of DES implanted in 2010 would go beyond 4.5 million worldwide. (ahajournals.org)
- The report includes forecast and analysis for the Durable Drug Eluting Stents market on a global and regional level. (prismcoalition.org)
- The study covers drivers and limitations of the Durable Drug Eluting Stents market along with the impact they have on the trade over the forecast period. (prismcoalition.org)
- Additionally, the report covers the study of possibilities available in the Durable Drug Eluting Stents market on a global level. (prismcoalition.org)
- The report aims to present a study of Global Durable Drug Eluting Stents Market along with accurate segmentation of market by type, solution, application and five major geographical regions. (prismcoalition.org)
- Global Durable Drug Eluting Stents market is supposed to witness a high increase during the forecast years due to expanding risk of data theft and firm government regulation. (prismcoalition.org)
- Along with strategically examining the key micro markets, the paper also focuses on industry-specific drivers, restraints, possibilities and challenges in the Durable Drug Eluting Stents market. (prismcoalition.org)
- The research methodology for Research Corridor's Durable Drug Eluting Stents market report utilizes a key of top-down and bottom-up research arrangements. (prismcoalition.org)
- The Drug Eluting Bioabsorbable Stents Market report offers perceptive information regarding drivers, restraints, opportunities, and trends of the Drug Eluting Bioabsorbable Stents Market. (worldwidemarketreports.com)
- With the use of historic data from (period), the Drug Eluting Bioabsorbable Stents Market report offers Y-o-Y growth and CAGR until 2026. (worldwidemarketreports.com)
- The global market for Drug Eluting Bioabsorbable Stents Market is expected to witness a CAGR of xx% over the forecast period 2020-2026 and is expected to reach US$ xx million in 2026, from US$ xx million in 2020. (worldwidemarketreports.com)
- Growth opportunities in the global Drug Eluting Bioabsorbable Stents Market across major regions during the forecast period. (worldwidemarketreports.com)
- Role of emerging markets in the global Drug Eluting Bioabsorbable Stents Market and the scenario during the 2020-2026. (worldwidemarketreports.com)
- New trends and advancements in the global Drug Eluting Bioabsorbable Stents Market. (worldwidemarketreports.com)
- The Europe Drug Eluting Stents Industry 2015 Market Research Report is a professional and in-depth study on the current state of the Drug Eluting Stents industry. (qyresearchreports.com)
- The Drug Eluting Stents market analysis is provided for the Europe markets including development trends, competitive landscape analysis, and key regions development status. (qyresearchreports.com)
- The research report investigates into the growth trajectory of the Europe drug eluting stents industry 2015 market research report market in order to provide valued insights to reader for understanding the structure of the market better. (qyresearchreports.com)
- The Europe drug eluting stents industry 2015 market research report market can be thus classified on the basis of end users, raw materials, products, applications, and regions. (qyresearchreports.com)
- Different trends that may negatively or positively impact the growth of the Europe drug eluting stents industry 2015 market research report market have also been measured in the report. (qyresearchreports.com)
- The vendor landscape has also been evaluated efficiently in the report of the Europe drug eluting stents industry 2015 market research report market. (qyresearchreports.com)
- Rising investments on healthcare and increasing patients coupled with expanding the market opportunities in developing nations are the factors boosting the growth of Drug-eluting stents market. (oganalysis.com)
- Additionally, growing of acceptance of stents as a feasible treatment and increase in the number of patients that are preferring drug-eluting stents are anticipated to strive the market growth. (oganalysis.com)
- The decline in average selling price of drug eluting stents is hampering the market growth. (oganalysis.com)
- The report provides detailed research and analysis into Drug-eluting stent industry long term trends, recent advancements, technological insights and new market dynamics. (oganalysis.com)
- Further, the list of top Drug-eluting stent companies as well as company wise SWOT analysis, current strategic interests and financial results are included in the Nebulizers report in order to provide detailed information on the market. (oganalysis.com)
- Drug eluting stent Market- Forecasts by Segments- Product and Application by geography. (oganalysis.com)
- 1.The report provides key statistics on the market status of the Coronary Stent manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry. (aarkstore.com)
- 4.The total market is further divided by company, by country, and by application/type for the competitive landscape analysis. (aarkstore.com)
- Further, expansion of the applications of non conventional modes of drug delivery such as pulmonary, nasal and transdermal in disease conditions other than respiratory and skin, especially in chronic disease conditions such as diabetes, CNS are also boosting the market. (marketsandmarkets.com)
- The polymer-based coating stent segment was dominating the global market and is estimated to remain dominant throughout the forecast period. (giiresearch.com)
- This report included the analysis of market overview, market characteristics, industry chain, competition landscape, historical and future data by types, applications and regions. (reportsnreports.com)
- An expert panel, which was asked by PMO to examine possibility of excluding such stents from price control as 'cheaper' Chinese devices are entering Indian market, has said it has found no data to back the move. (indianexpress.com)
- The domestic stent firms have stated that they have been gaining market share after the price cap. (indianexpress.com)
- Multinational companies have a share of more than 50 per cent in India's stent market, according to industry sources. (indianexpress.com)
- A person privy to the development said the company's representatives met National Pharmaceutical Pricing Authority (NPPA) officials on Tuesday, seeking to withdraw its next-generation product "Synergy" stent from the market. (livemint.com)
- Additionally, Meril Life Sciences-manufacturer of indigeneous BVS stents-has halted the launch of new stents in the market. (livemint.com)
- This report categorizes the drug-device combination market by products, applications, and technology, each of which is further categorized into its individual submarket. (marketsandmarkets.com)
- No single report by any other publisher provides market data for all market segments (i.e. products, services, applications, ingredients, and technology) covering the four geographies of North America, Europe, Asia Pacific, and ROW. (marketsandmarkets.com)
- Based on Application, the Stent Grafts Market studied across Abdominal Aortic Aneurysm and Thoracic Aortic Aneurysm. (reportbuyer.com)
- The report deeply explores the recent significant developments by the leading vendors and innovation profiles in the Global Stent Grafts Market including AptusEndosystem, Bolton Medical, GRIKIN Advanced Materials, Johnson & Johnson, LifeTech Scientific, Lombard Medical Technologies, Terumo, TriVascular Technologies, and Wl Gore & Associates. (reportbuyer.com)
- The FPNV Positioning Matrix evaluates and categorizes the vendors in the Stent Grafts Market on the basis of Business Strategy (Business Growth, Industry Coverage, Financial Viability, and Channel Support) and Product Satisfaction (Value for Money, Ease of Use, Product Features, and Customer Support) that aids businesses in better decision making and understanding the competitive landscape. (reportbuyer.com)
- 1. What is the market size and forecast of the Global Stent Grafts Market? (reportbuyer.com)
- 2. What are the inhibiting factors and impact of COVID-19 shaping the Global Stent Grafts Market during the forecast period? (reportbuyer.com)
- 3. Which are the products/segments/applications/areas to invest in over the forecast period in the Global Stent Grafts Market? (reportbuyer.com)
- 4. What is the competitive strategic window for opportunities in the Global Stent Grafts Market? (reportbuyer.com)
- 5. What are the technology trends and regulatory frameworks in the Global Stent Grafts Market? (reportbuyer.com)
- 6. What are the modes and strategic moves considered suitable for entering the Global Stent Grafts Market? (reportbuyer.com)
- The report on the Drug-Eluting Balloons Market gives a foot perspective on the present continuing inside the Drug-Eluting Balloons market. (galusaustralis.com)
- Further, the report likewise considers the effect of the novel COVID-19 pandemic on the Drug-Eluting Balloons market and offers an away from of the anticipated market variances during the estimate time frame. (galusaustralis.com)
- In 2027, the Drug-Eluting Balloons market is spectated to outperform ~US$ xx Mn/Bn with a CAGR of xx% over the estimate time frame. (galusaustralis.com)
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- The whole analysis of the Drug-Eluting Balloons market. (galusaustralis.com)
- Information regarding advanced development and technology innovation for the Drug-Eluting Balloons market. (galusaustralis.com)
- The Drug-Eluting Balloons market is examined and showcase size data is given by region. (galusaustralis.com)
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- Biotechnology applications recorded for the biggest share of the Q-TOF mass spectrometry market in 2016towing to the increasing use of Q-TOF mass spectrometers for quantitative and qualitative analyses in the quickly increasing research areas of proteomics and metabolomics. (reportlinker.com)
- The industry report examines the Q-TOF mass spectrometry market and aims at estimating the market value and the future increase potential of this market established on different segments including application and area. (reportlinker.com)
- The Global drug eluting stents market research report 2016 market has multinational players functioning on the field with different varieties of products to deliver. (qyresearchreports.com)
- The global drug-device combination products market is segmented based on product, application, end user, and region. (openpr.com)
- Comparison of the test results with mathematically modeled data acquired using finite element methods demonstrated a good agreement between modeled data and experimental results indicating that gel hydrophobicity will only influence release in cases of fast releasing stent coatings. (springer.com)
- Paclitaxel releasing films consisting of poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) and their potential as biodegradable stent coatings. (springer.com)
- Tailored drug release from biodegradable stent coatings based on hybrid polyurethanes. (springer.com)
- The newer generations of drug-eluting stents use different platforms, different drugs, and improved polymer coatings. (medpagetoday.com)