Myocardial Depressant Factor
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Central Nervous System Depressants
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Hypnotics and Sedatives
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.
Muscle Relaxants, Central
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
Dose-Response Relationship, Drug
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Glucagon-Like Peptide 1
A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Thermogenic effects of sibutramine and its metabolites. (1/354)1. The thermogenic activity of the serotonin and noradrenaline reuptake inhibitor sibutramine (BTS 54524; Reductil) was investigated by measuring oxygen consumption (VO2) in rats treated with sibutramine or its two pharmacologically-active metabolites. 2. Sibutramine caused a dose-dependent rise in VO2, with a dose of 10 mg kg(-1) of sibutramine or its metabolites producing increases of up to 30% that were sustained for at least 6 h, and accompanied by significant increases (0.5-1.0 degrees C) in body temperature. 3. Based on the accumulation in vivo of radiolabelled 2-deoxy-[3H]-glucose, sibutramine had little or no effect on glucose utilization in most tissues, but caused an 18 fold increase in brown adipose tissue (BAT). 4. Combined high, non-selective doses (20 mg kg(-1)) of the beta-adrenoceptor antagonists, atenolol and ICI 118551, inhibited completely the VO2 response to sibutramine, but the response was unaffected by low, beta1-adrenoceptor-selective (atenolol) or beta2-adrenoceptor-selective (ICI 118551) doses (1 mg kg(-1)). 5. The ganglionic blocking agent, chlorisondamine (15 mg kg(-1)), inhibited completely the VO2 response to the metabolites of sibutramine, but had no effect on the thermogenic response to the beta3-adrenoceptor-selective agonist BRL 35135. 6. Similar thermogenic responses were produced by simultaneous injection of nisoxetine and fluoxetine at doses (30 mg kg(-1)) that had no effect on VO2 when injected individually. 7. It is concluded that stimulation of thermogenesis by sibutramine requires central reuptake inhibition of both serotonin and noradrenaline, resulting in increased efferent sympathetic activation of BAT thermogenesis via beta3-adrenoceptor, and that this contributes to the compound's activity as an anti-obesity agent. (+info)
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke. (2/354)AIMS: To estimate the incidence of newly diagnosed idiopathic stroke among users of fenfluramine, dexfenfluramine and phentermine compared to obese nonusers. METHODS: We conducted a cohort study with nested case-control analysis utilizing data from the General Practice Research Database in the UK. Eight thousand four hundred and twenty-three subjects aged 69 years or less at the start of follow-up were exposed to at least one of the three study drugs and 17 225 similarly obese subjects were not exposed to any of the study drugs. RESULTS: We identified 45 incident cases of idiopathic CVA in this cohort of subjects. The incidence of CVA among all current users of a diet drug was 1.3/1000 person-years (95% CI 0.5, 3.5). The incidence for current fenfluramine users (n=2) was 2.6/1000 person-years (95% CI 0.7, 9.6), for current dexfenfluramine users (n=1) 1.1/1000 person-years (95% CI 0.3, 3.8), and for current phentermine users 0/1000 person-years (95% CI 0.0, 12.9). The incidence in obese nonusers was 0.6/1000 person-years (95% CI 0.4, 0. 9). The adjusted matched odds ratio (OR) for thrombotic stroke from the case-control analysis comparing current use of a diet drug to nonuse was 2.4 (95% CI 0.6, 9.1). There was only one exposed subject among seven who had haemorrhagic stroke. CONCLUSIONS: The incidence of CVA in generally young obese subjects during use of fenfluramine, dexfenfluramine or phentermine is low. Although we found an OR of 2. 4 comparing users of any of the anorexiants with nonusers, this is based on only three exposed cases and the confidence limits are wide. We conclude that our study does not support a substantial increased risk of stroke attributable to the use of fenfluramine, dexfenfluramine or phentermine. (+info)
Amphetamine and fenproporex levels following multidose administration of fenproporex. (3/354)Drugs that are metabolized to amphetamine or methamphetamine are potentially of significant concern in the interpretation of positive drug-testing results for amphetamines. A number of different drugs have been reported to produce amphetamine in the urine of users. One of these compounds, fenproporex, has been shown to be metabolized to amphetamine, and previous reports indicated the parent compound could be detected at low levels for up to 48 h. Administration of fenproporex for seven days (one 10-mg dose per day) to five healthy volunteers resulted in amphetamine being detected in the urine of all subjects. Peak concentrations of amphetamine ranged from approximately 2850 to 4150 ng/mL. Amphetamine could be detected (> or = 5 ng/mL) in the urine for up to nearly 170 h after the last dose. Analysis of the metabolically produced amphetamine showed the presence of both enantiomers, which can be helpful in the differentiation of some illicit amphetamine use from the use of this precursor drug. In addition, evaluation of the enantiomeric composition of the metabolite (amphetamine) can be a valuable tool in the interpretation of time since last dose. More significantly, all samples that contained amphetamine at a concentration of > or = 500 ng/mL were shown to also contain detectable amounts of the parent compound. (+info)
Pharmacologic induction of weight loss to treat type 2 diabetes. (4/354)OBJECTIVE: Most individuals with type 2 diabetes are overweight, and weight loss for them is an important therapeutic objective. However, usual weight-loss strategies have generally not produced sustained weight loss. Pharmacologic agents to assist weight loss might be useful, but no long-term data on their effectiveness and safety in patients with type 2 diabetes are available. We therefore initiated a 2-year placebo-controlled trial of the weight-loss medications fenfluramine and phentermine in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS: A total of 44 overweight (> 120% ideal body weight) subjects with type 2 diabetes were enrolled in a randomized, placebo-controlled, double-blind trial of fenfluramine and phentermine. All subjects received intensive nutrition counseling, an exercise prescription, and instruction in behavior modification. Subjects were randomly assigned to 20 mg fenfluramine three times a day and 37.5 mg phentermine daily (n = 23) or dual placebos (n = 21). Diabetes medications were adjusted as necessary to achieve glycemic goals. Changes in weight, glycemia, lipemia, and blood pressure were assessed every 2 months, as were adverse events. In September 1997, when fenfluramine was withdrawn from the U.S. market, fenfluramine was stopped in all subjects. Thus the length of drug treatment varied, but 16 subjects (8 in each group) reached 12 months of treatment. Only data obtained before the withdrawal of fenfluramine are included in this report. RESULTS: A study termination, diabetes medications had been reduced in 1 subject in the placebo group (5%) and 11 subjects in the drug treatment group (52%) (P = 0.005). Drug treatment resulted in significant reductions in body weight, BMI, and HbA1c at all time points through 6 months. Changes in weight at 6 months were -2.7 +/- 1.4 kg (mean +/- SEM) with placebo treatment and -9.6 +/- 1.5 kg with drug treatment (P = 0.003). Even though more subjects in the drug treatment group required reductions in diabetes medications, at 6 months, changes in HbA1c were -0.3 +/- 0.2% with placebo treatment and -1.6 +/- 0.3% with drug treatment (P = 0.002). Fasting plasma glucose and triglycerides were significantly reduced at some time points with drug treatment. No serious adverse events attributable to study medications were observed. CONCLUSIONS: Premature study termination decreased the power of our study at later time points. However, our data suggest that weight loss medications are an effective treatment for type 2 diabetes during active weight loss. Whether the benefit persists after weight loss has stopped remains to be determined. (+info)
Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. (5/354)OBJECTIVE: The gut hormone glucagon-like peptide 1 (GLP-1) has insulinotropic and anorectic effects during intravenous infusion and has been proposed as a new treatment for type 2 diabetes and obesity. The effect of a single subcutaneous injection is brief because of rapid degradation. We therefore sought to evaluate the effect of infusion of GLP-1 for 48 h in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We infused GLP-1 (2.4 pmol.kg-1.min-1) or saline subcutaneously for 48 h in randomized order in six patients with type 2 diabetes to evaluate the effect on appetite during fixed energy intake and on plasma glucose, insulin, glucagon, postprandial lipidemia, blood pressure, heart rate, and basal metabolic rate. RESULTS: The infusion resulted in elevations of the plasma concentrations of intact GLP-1 similar to those observed after intravenous infusion of 1.2 pmol.kg-1.min-1, previously shown to lower blood glucose effectively in type 2 diabetic patients. Fasting plasma glucose (day 2) decreased from 14.1 +/- 0.9 (saline) to 12.2 +/- 0.7 mmol/l (GLP-1), P = 0.009, and 24-h mean plasma glucose decreased from 15.4 +/- 1.0 to 13.0 +/- 1.0 mmol/l, P = 0.0009. Fasting and total area under the curve for insulin and C-peptide levels were significantly higher during the GLP-1 administration, whereas glucagon levels were unchanged. Neither triglycerides nor free fatty acids were affected. GLP-1 administration decreased hunger and prospective food intake and increased satiety, whereas fullness was unaffected. No side effects during GLP-1 infusion were recorded except for a brief cutaneous reaction. Basal metabolic rate and heart rate did not change significantly during GLP-1 administration. Both systolic and diastolic blood pressure tended to be lower during the GLP-1 infusion. CONCLUSIONS: We conclude that 48-h continuous subcutaneous infusion of GLP-1 in type 2 diabetic patients 1) lowers fasting as well as meal-related plasma glucose, 2) reduces appetite, 3) has no gastrointestinal side effects, and 4) has no negative effect on blood pressure. (+info)
Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats. (6/354)The effect of the 5-hydroxytryptamine (5-HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)- or muscimol-injected rats. Sibutramine dose-dependently reduced feeding caused by food-deprivation (ED50 = 5.1+/-0.8 mg kg(-1)) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED50 = 6.0+/-0.5 mg kg(-1)). The increase in food intake caused by muscimol injected into the dorsal raphe was not modified by sibutramine (1-10 mg kg(-1)). The hypophagic effect of 5.1 mg kg(-1) sibutramine in food-deprived rats was studied in rats pretreated with different serotonin receptor antagonists. Metergoline (non-selective, 0.3 and 1.0 mg kg(-1)), ritanserin (5-HT2A/2C, 0.5 and 1.0 mg kg(-1)) and GR127935 (5-HT1B/1D), 0.5 and 1.0 mg kg(-1)) did not modify the hypophagic effect of sibutramine, while SB206553 (5-HT2B/2C, 5 and 10 mg kg(-1)) slightly but significantly reduced it (Fint(2.53) = 3.4; P<0.05). The reduction in food intake caused by 6.0 mg kg(-1) sibutramine in NPY-injected rats was not modified by GR127935 (1.0 mg kg(-1)). The results suggest that, with the possible exception of a partial involvement of 5-HT2B/2C receptors in sibutramine's hypophagia in food-deprived rats, 5-HT1 and 5-HT2 receptor subtypes do not play an important role in the hypophagic effect of sibutramine, at least in the first 2 h after injection. (+info)
Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. (7/354)BACKGROUND: Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough. METHODS AND RESULTS: We tested the hypothesis that fenfluramine (and other anorexic agents) might increase the risk of PPH through interactions with serotonin (5-HT) transporters. Because 5-HT transporter proteins in the lung and brain are identical, we examined, in rat brain, the effects of selected drugs on 5-HT efflux in vivo and monoamine transporters in vitro as a generalized index of transporter function. Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. CONCLUSIONS: We speculate that medications that are 5-HT transporter substrates get translocated into pulmonary cells where, depending on the degree of drug retention, their intrinsic drug toxicity, and individual susceptibility, PPH could develop as a response to high levels of these drugs or metabolites. Emerging evidence suggests that it is possible to develop transporter substrates devoid of adverse side effects. Such medications could have therapeutic application in the management of obesity, drug dependence, depression, and other disorders. (+info)
The promotion effect of anorectic drugs on aflatoxin B(1)-induced hepatic preneoplastic foci. (8/354)The ability of three extensively used anorectic drugs, namely fenfluramine (FN), fluoxetine (FX) and amphetamine (AM), to alter the development of aflatoxin B(1) (AFB(1))-induced gamma-glutamyl-positive (GGT(+)) preneoplastic liver foci was investigated in 135 male weanling F344 rats. Following AFB(1) administration, 15 rats were killed, while the rest were divided into four groups and fed diets containing either FN, FX, AM or control diet, with half of the animals in each group subsequently being killed at 4 weeks and half at 10 weeks. All three anorectic drugs as expected suppressed initial food intake, growth rate, body weight gain and food efficiency. They also tended to suppress body fat mass and to decrease plasma levels of T(3) and T(4). FN significantly (P < 0.05) increased GGT(+) foci number/cm(2) and number/cm(3), while FX significantly increased GGT(+) foci number/cm(2) and the volume fraction of foci. Histopathological staining also revealed that FN- and FX-treated animals had more serious morphological alterations in their liver tissue. In contrast, foci development was, if anything, suppressed by AM feeding. These results indicate that serotoninergic drugs (FN and FX), as opposed to dopaminergic drugs (AM), may have tumor promoter activity, at least for liver tissue. (+info)
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Anti-depressants do not prevent recurrence. Several drug therapies have been used on patients with KLS, but none of them have ... Excessive appetite (hyperphagia) and unusual cravings are present in half to two thirds of cases. About half of patients, ... In 1815, there was a report of a young man who showed excessive appetite and prolonged sleep after experiencing a fever; this ... Levin noted that some patients displayed an intense appetite in addition to their persistent tiredness. MacDonald Critchley, ...
Cotreatment with CNS depressants such as the benzodiazepines can cause additive CNS depression. Co-treatment with thyroid ... increased appetite, and weight gain, all were not observed. Clinical evidence of H1 receptor antagonists and TCAs for the ... In general, sedating properties of anti-depressant agents are related to antagonism of serotonin 5HT2, histamines, and α-1 ... Alcohol may potentiate some of the CNS depressant effects of doxepin. Antihypertensive agents may have their effects mitigated ...
Severe headache, restlessness, irritability, loss of appetite, body aches, severe abdominal pain, nausea and vomiting, tremors ... given that morphine is a central nervous system depressant. Morphine has resulted in impaired functioning on critical flicker ... loss of appetite, and the beginning of intestinal cramping Stage IV, 24 h to 36 h after last dose: Increase in all of the above ... Recovery of appetite and normal bowel function, beginning of transition to postacute and chronic symptoms that are mainly ...
The drug has also been used as an appetite suppressant in Europe. Propylhexedrine is not an amphetamine, though it is ... Antidepressants Depressants Hallucinogens Nootropics Psychoanaleptics The active ingredient in some OTC inhalers in the United ... Khat contains a monoamine alkaloid called cathinone, a "keto-amphetamine", that is said to cause excitement, loss of appetite, ... Rasmussen N (July 2006). "Making the first anti-depressant: amphetamine in American medicine, 1929-1950". J. Hist. Med. Allied ...
It is seen in insect processes in roles similar to in the human central nervous system, such as memory, appetite, sleep, and ... such as fluoxetine and sertraline anti-depressants, inhibit PMAT but at IC50 values which surpass the therapeutic plasma ... When humans smell food, dopamine is released to increase the appetite. But, unlike in worms, serotonin does not increase ... This halts their dopamine release, and thereby serotonin decreases appetite. Drugs that block 5-HT2C receptors make the body ...
It was used in the Soviet Union during the 1930s and 1940s as an anti-depressant (under the name Эфедрон-ephedrone). ... and causes appetite suppression. Users can easily forget to consume fluids leading to increased thirst and ...
Effects of cannabis
The feeling of increased appetite following the use of cannabis has been documented for hundreds of years, and is known ... While psychoactive drugs are typically categorized as stimulants, depressants, or hallucinogens, cannabis exhibits a mix of all ... Fride E, Bregman T, Kirkham TC (April 2005). "Endocannabinoids and food intake: newborn suckling and appetite regulation in ... or appetite for breast milk" and recent research has identified the endogenous cannabinoid system to be the first neural system ...
List of designer drugs
Harm S (11 April 1967). "US Patent 3313687 - Appetite-suppressing and weight reducing composition". "4F-IVP". Cayman Chemical. ... Many dissociatives have general depressant effects and can produce sedation, respiratory depression, analgesia, anesthesia, and ...
... is used as a short-term sedative and anxiolytic for cats and dogs, sometimes used as an appetite stimulant. It can ... The impairment is worsened by consumption of alcohol, because both act as central nervous system depressants. During the course ... "Drugs Affecting Appetite (Monogastric)". The Merck Veterinary Manual. Archived from the original on 28 October 2012. Retrieved ... Overdoses of diazepam with alcohol, opiates or other depressants may be fatal. If diazepam is administered concomitantly with ...
Severely afflicted by internal conflicts; his loss of appetite for life, love of his wife, and external pressures; managing his ... Kramer, Peter D (21 December 1997). "What Ivanov Needs in the 90's Is an Anti-Depressant". New York Times. Retrieved 17 ...
Increasing attention, for instance, was paid to his appetite for the rich, heavy Southern cooking of his upbringing, foods such ... Cyril Wecht conducted a review of the reports and concluded that a combination of central nervous system depressants had ...
When mice that showed depressive symptoms were administered anti-depressant drugs, their levels of p11 were found to increase ... appetite, sleep, and mood. Varying levels of serotonin found in the brain are associated with the development of mood disorders ... Antidepressant manipulations increase the p11 levels, whereas depressant manipulations reduce it. Therefore, in order to ...
As with other benzodiazepines, temazepam produces additive CNS-depressant effects when coadministered with other medications ... Hyperhydrosis, hypotension, burning eyes, increased appetite, changes in libido, hallucinations, faintness, nystagmus, vomiting ...
Medical cannabis in the United States
Brecher, Edward M. (1972). Licit and Illicit Drugs: The Consumers Union Report on Narcotics, Stimulants, Depressants, Inhalants ... and additionally in 1992 as an appetite stimulant for treatment of AIDS-related weight loss. It was initially classified as a ...
Depression and immune function
... trials have shown that these benefits often outperform placebos when used on their own or in conjunction with anti-depressants ... mood and anxiety are brought about less in patients relative to increases in symptoms relating to reduced activity and appetite ...
Serotonin-norepinephrine-dopamine reuptake inhibitor
... decreased appetite (and hence weight loss), increased locomotor activity (LMA) etc. In the United States, cocaine overdose is ... "SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity". Acta Pharmacologica Sinica. 34 (9): 1149- ... "Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions ...
MGA is frequently used as an appetite stimulant to promote weight gain. The direct mechanism of appetite enhancement is unclear ... Tisell LE, Salander H (February 1975). "Androgenic properties and adrenal depressant activity of megestrol acetate observed in ... Appetite stimulation is achieved with MGA with oral dosages of 400 to 800 mg/day. The optimal dosage with maximum effect for ... Appetite enhancement induced by megestrol acetate might be partly due to the inhibition of these Ca2+ channel currents, and the ...
Similarly to other intermediate-acting depressants, it may be used as hypnotic medication or in order to mitigate withdrawal ... appetite loss, hallucinations, delirium, seizures, tremor, stomach cramps, myalgia, agitation, palpitations, tachycardia, panic ... The toxicity of bromazepam in overdosage increases when combined with other CNS depressant drugs such as alcohol or sedative ... The impairment is worsened by consumption of alcohol, because both act as central nervous system depressants. During the course ...
Symptoms of withdrawal commonly include nausea, vomiting, and loss of appetite. Other symptoms may include restlessness, ... FDA urges caution about withholding opioid addiction medications from patients taking benzodiazepines or CNS depressants: ... which may underlie its low propensity for appetite stimulation and weight gain. The drug also has negligible affinity for the ...
Anxiolytics (CNS depressants such as benzodiazepines and barbiturates): Kava may have potential additive CNS depressant effects ... loss of appetite and indigestion. These adverse health effects, while significant, are considered to be reversible upon ... CNS depressants such as benzodiazepines), antipsychotics, levodopa, diuretics, and drugs metabolized by CYP450 in the liver. A ...
In particular, amphetamine may decrease the effects of sedatives and depressants and increase the effects of stimulants and ... Other potential physical side effects include appetite loss, blurred vision, dry mouth, excessive grinding of the teeth, ... Amphetamine withdrawal symptoms can include anxiety, drug craving, depressed mood, fatigue, increased appetite, increased ...
Some early symptoms include tiredness, weakness, loss of appetite, weight loss, and nausea. People may also feel discomfort in ... These include several drugs such as anti-depressants, certain antibiotics, and NSAIDs (like ibuprofen). These agents are ... Early symptoms may include tiredness, weakness, loss of appetite, unexplained weight loss, nausea and vomiting, and discomfort ...
Early studies in rodents found that orexins (derived from Greek "orexis" meaning "appetite") stimulate appetite, feeding ... Dosage adjustment may be necessary when suvorexant is combined with other CNS depressants. Use of suvorexant in combination ... John's wort (expected to decrease suvorexant effectiveness). Coadministration of suvorexant with other CNS depressants such as ...
... s are depressants that enhance the effect of the neurotransmitter gamma-aminobutyric acid (GABA) at the GABAA ... Less common side effects include nausea and changes in appetite, blurred vision, confusion, euphoria, depersonalization and ... Combined with other central nervous system (CNS) depressants such as alcohol and opioids, the potential for toxicity and fatal ... ISBN 978-0-19-852748-0. McIntosh A, Semple D, Smyth R, Burns J, Darjee R (2005). "Depressants". Oxford Handbook of Psychiatry ( ...
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Weight and Body Composition
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What makes marijuana a depressant or a stimulant? - searchandrestore.com
Is marijuana an appetite stimulant?. Cannabis ability to stimulate appetite is well known on a casual level, but clinical ... What makes marijuana a depressant or a stimulant?. What makes marijuana a depressant or a stimulant?. But after all these years ... Nicotine seems to provide both a stimulant and a depressant effect, and it is likely that the effect it has at any time is ... Cannabis cant be definitively placed in a major drug category, but some people consider it a depressant with stimulant ...
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- Some medications like anti-depressants can cause weight gain by increasing your appetite and slowing down your metabolism. (americaswire.org)
- This includes antidepressants, anti-depressants (for obsessive-compulsive disorder), appetite stimulants (eg, vardenafil) and sleeping aids (eg, dexedrine), testosterone injection morning or night. (abiteofvegan.com)
- Avoid using anti-convulsants and antihistamines alongside anti-depressants, as they may worsen side effects, injecting steroids with air bubbles. (abiteofvegan.com)
- Certain anti-depressants are also responsible for appetite loss. (thechannel46.com)
- In the East Pole Kingdom, among the eight hundred miles of mountains outside the East Pole City, We, Gong Yuanchuan and the I found a anti depressants are an appetite suppressant mountains. (glamour-nails.org)
- The plant has been used medicinally for its stimulants, nervine, astringent, and appetite depressant properties. (botano.gr)
- Most people understand that sleeping pills and sedatives, like Xanax and Valium, are depressants, whereas caffeine and cocaine are stimulants. (searchandrestore.com)
- Even if we do not have a licensed doctor to guide buying Epinephrine Injection, we can assist you to treat whatever is In general, buying Epinephrine Injection have depressant effects while stimulants have stimulant effects. (sprayflexsprayers.com)
- Two of the most common drug classifications are depressants and stimulants. (paracelsus-recovery.com)
- With continued use of depressants or stimulants, the body builds up a tolerance for the drug. (paracelsus-recovery.com)
- Combining depressants and stimulants is extremely risky. (paracelsus-recovery.com)
- Withdrawal of depressants and stimulants is dangerous and detox must be medically supervised. (paracelsus-recovery.com)
- There are many types of depressants and stimulants. (paracelsus-recovery.com)
- Both depressants and stimulants can be addictive. (paracelsus-recovery.com)
- People often use depressants to get rid of the unpleasant "upping" effect of stimulants and once a calming effect is reached, they "crash" and need "uppers" to even get going again. (paracelsus-recovery.com)
- People addicted to stimulants and/or depressants, be it prescription medication, illegal drugs or alcohol, require careful and medically supervised detox and addiction treatment in order to be able to live a normal drug-free life again. (paracelsus-recovery.com)
- Stimulants can also reduce your appetite, increase agitation, and induce sleepiness. (ardurecoverycenter.com)
Prescribed an anti-depressant2
- The vet prescribed an anti-depressant in the hopes of stimulating her appetite. (funfoodlife.com)
- I tried home remedies, every single over-the-counter pain killer ever made, I tried going to the doctor about them and was prescribed an anti-depressant that also helps with pain (umm, no thanks), and I tried anything and everything else in the book to help prevent or cure my migraines and nothing did the trick. (livinglikelinds.com)
- You wouldn't have known that the use of amphetamines as appetite suppressants in the mid-twentieth century helped unleash an epidemic of addiction on both sides of the Atlantic, which by the 1970's led to several U.S. Congressional hearings on the amphetamine crisis . (rxisk.org)
- But you need not be discouraged by the statistical data, as medical science has finally found a perfect solution to it - Appetite Suppressants . (iuventusmedcenter.com)
- Here is what you need to know and understand about appetite suppressants. (iuventusmedcenter.com)
- What Are Appetite Suppressants? (iuventusmedcenter.com)
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- How Do Appetite Suppressants Work? (iuventusmedcenter.com)
- In medical terms, appetite suppressants are known as Anorectics. (iuventusmedcenter.com)
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- When you consume appetite suppressants, the food intake frequency and quantity reduce. (iuventusmedcenter.com)
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Natural appetite suppressant4
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- What causes the weight gain associated with anti-depressant drugs: slowed metabolism, increased appetite, increased insulin resistance, other? (healthtap.com)
- However, there are a lot of claims that it can treat various diseases such as nausea, pain, and loss of appetite. (drug.education)
- Thakur, in his petition, asked the court to direct the Union health ministry to ban three drugs from the Indian market -- appetite stimulant buclizine , anti-depressant flupenthixol+melitracen and painkiller aceclofenac+drotavarine. (indiatimes.com)
- The health ministry on December 13 banned the use of buclizine as an appetite stimulant, nearly a week after the court's order. (indiatimes.com)
- As early as 2013, the health ministry's New Drugs Approval Committee (NDAC) found "no convincing literature" to support the use of buclizine as an appetite stimulant for children. (indiatimes.com)
- What makes marijuana a depressant or a stimulant? (searchandrestore.com)
- Cannabis can't be definitively placed in a major drug category, but some people consider it a depressant with stimulant properties. (searchandrestore.com)
- Is tobacco classified as a stimulant or a depressant? (searchandrestore.com)
- Nicotine seems to provide both a stimulant and a depressant effect, and it is likely that the effect it has at any time is determined by the mood of the user, the environment and the circumstances of use. (searchandrestore.com)
- Studies have suggested that low doses have a depressant effect, whilst higher doses have stimulant effect. (searchandrestore.com)
- Is marijuana an appetite stimulant? (searchandrestore.com)
- Cannabis' ability to stimulate appetite is well known on a casual level, but clinical trials on medical marijuana as an appetite stimulant provide scientific evidence as well. (searchandrestore.com)
- Other medications include the anti-depressant fluoxetine, the appetite stimulant Ritalin and more, what is the best sarms for bulking. (ichikawa-yusanbako.com)
- Anxiety can sometimes result in decreased appetite. (thechannel46.com)
Types of depressants1
- All of these different types of depressants and hypnotics affect moods and behaviour. (sprayflexsprayers.com)
- But this finding shows that it is feasible to alter parts of the leptin-serotonin pathway to decrease appetite without weakening bone. (nutritionreview.org)
- Supplements To Decrease Appetite. (glamour-nails.org)
- Weight loss is commonly accompanied by decrease appetite, but cancer patients who are eating adequate amount of food still can experience weight loss due to increases in inflammation and body metabolism. (chemoexperts.com)
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- Phentermine is an appetite suppressant used along with diet, exercise, and behavior therapy for the short-term management of obesity. (cheapmeds4u.com)
Suppress your appetite1
- Bacterial, viral and fungal infections like the common flu and cold, food poisoning, gastroenteritis, and colitis can often suppress your appetite. (thechannel46.com)
- Downers (depressants) do just the opposite. (medlineplus.gov)
- Loss of appetite is a common side effect of certain medications. (thechannel46.com)
- While these medications can increase appetite and improve mood, they can also cause drowsiness, dry mouth, difficulty thinking and, in some cases, can cause extreme paranoia or hallucinations. (chemoexperts.com)
- The primary active compound in cannabis, tetrahydrocannabinol or THC, is believed to be the single most active chemical in cannabis' ability to stimulate appetite. (searchandrestore.com)
- Corticosteroids can be given to help stimulate appetite by decreasing inflammation and increasing signals the body uses to increase appetite. (chemoexperts.com)
- Mirtazapine is an anti-depressant but can help stimulate appetite by blocking a receptor in the brain which results in increased food intake. (chemoexperts.com)
- The side-effects include fatigue, any type of change in the weight or appetite or diarrhea. (138315.net)
Lack of appet3
- Iron is an extremely important essential element and its deficiency causes anaemia, which can be responsible for the lack of appetite. (thechannel46.com)
- Symptoms include sleeping or eating too much, not being able to sleep, lack of appetite or craving carbohydrates, especially sweets. (unchealthcare.org)
- This strain can be beneficial for those dealing with discomfort, a lack of appetite, insomnia, sadness, and stress, as it frequently reduces stress. (farmerslabseeds.com)
Effects of alco2
- CNS Depressants: Trazodone may enhance effects of alcohol, barbiturates, or other CNS depressants ( 7 ). (nih.gov)
- for this high percentage is likely due to the depressant effects of alcohol. (1library.net)
- Marijuana and alcohol are also depressants. (paracelsus-recovery.com)
- Prescription cannabinoids contain the active ingredient in marijuana, tetrahydrocannabinol (THC), which stimulates appetite. (chemoexperts.com)
- Cannabis drugs such as marijuana may cause relaxation, impaired motor skills, and increased appetite. (medlineplus.gov)
- Overdosing on depressants, opiates (like heroin and morphine), and minor tranquilizers affects your concentration and coordination, making everyday tasks impossible and even dangerous. (ardurecoverycenter.com)
Responsible for appetite1
- In a study on rats, Kratom showed positive results on inhibiting the hypothalamus, responsible for appetite and hunger. (thebestfashion.co)
- Constipation with poor appetite. (italisvital.info)
- While the government last week banned buclizine for appetite stimulation, the rest of the drugs are still available in the Indian market. (indiatimes.com)
- Amphetamine and Psychostimulant Drugs Amphetamine, methamphetamine, and dextroamphetamine are powerful analeptics that are used because of their psychostimulant and appetite depressant effects. (meatandsupplyco.com)
- The actions of some appetite-depressant drugs such as fenfluramine, are reduced by administration of vitamin C. (healthysolutionstx.com)
- Neobes 75mg is a appetite depressant considered to produce less central nervous system disturbance than most drugs in this therapeutic category. (bestsuppliermeds.com)
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- Commonly prescribed depressants include drugs commonly known as Benzodiazepines or in short "Benzos" and Morphine. (paracelsus-recovery.com)
- Furthermore, leptin was found to not act in the hypothalamus as previously thought, but in the brain stem acting on serotonin, a hormone that in the brain acts to control appetite, mood and anger. (nutritionreview.org)
- Appetite is influenced by many reasons ranging from mood and emotions to mental and physical health. (thechannel46.com)
- It has nothing to do with me Wen Liang turned around and motioned what can suppress appetite The womenaoning bit her lower lip and swung her best otc appetite suppressant and fat burner 2021 . (glamour-nails.org)
- Dr. Karsenty points out that these current findings may have more influence on developing a new way to reduce appetite and obesity than preventing osteoporosis. (nutritionreview.org)
- In the past they were used to treat obesity by decreasing appetite. (paracelsus-recovery.com)
- This medication blocks the action of serotonin, which can suppress appetite. (chemoexperts.com)
- It promotes weight loss by the dual action of reducing appetite and improving metabolism. (botano.gr)
- New research from Columbia University Medical Center has illuminated a previously unknown leptin-serotonin pathway in the brain that simultaneously promotes appetite and bone mass accrual. (nutritionreview.org)
- Eating small meals at regular intervals promotes healthy digestion, which aids in improving the appetite. (thechannel46.com)
- Megestrol is thought to increase appetite by releasing hormones that promote appetite and by decreasing inflammation as well. (chemoexperts.com)
- Amitriptyline is commonly prescribed as an anti-depressant and is used for the treatment of major depression. (fastmedstore.com)
- Alcohol is a CNS depressant. (medscape.com)
- Although we believe alcohol relaxes us, it's actually a depressant. (unchealthcare.org)
- Infants, young children, and pregnant and lactating women are at a greater risk of zinc deficiency and one of the most common symptoms of zinc deficiency is loss of appetite. (thechannel46.com)
- Episodes may be accompanied by various somatic symptoms including psychomotor retardation, agitation, loss of appetite, weight loss, and loss of libido. (cdc.gov)
Curve my appetite1
- I smiled casually, Furthermore, since your Majesty xenical tablets do they work The women assisted him As a law official, he was naturally more righteous than I came to nutrition plan for fat loss female curve my appetite is too cruel Despite the fact that The manling and She's contacts have been floating in the past few months. (ethicsfirst.eu)
- However, you will also see the seeds mentioned in many weight loss formulas as this is an effective appetite depressant. (botano.gr)
- Before we come to how to increase appetite, let's take a look at a few reasons why people may experience a loss of appetite. (thechannel46.com)
- As your body goes through many changes during pregnancy, it is common to experience appetite loss during this period. (thechannel46.com)
- The stress response can affect your stomach and digestive tract, leading to loss of appetite or no appetite. (thechannel46.com)
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- Immediately, the gaze in the bloody light moved away, as if there was substance, it penetrated the best otc appetite suppressant blood light eroded the admiral's dome and the billions does medical weight loss clinics really work before He's eyes, countless boulders fell down and smashed on the blood light, disappearing like xenical tablets do they work. (ethicsfirst.eu)
- medical weight loss center fort myers a moment, and then asked He, It, do you recognize I from the Lin natural supplements to curb appetite Shuwan is still my cousin. (glamour-nails.org)
- Although he probably heard that the bristles factory collapsed at the hands of They, he didnt know exactly what happened to the bristles factory later In this life, when the doctor went to Beijing for treatment, The weight loss pills appetite control. (glamour-nails.org)
- The best ab exercises for weight loss from the portable quickest weight loss ever.rapid weight loss secrets what's the problem It thought for a while, but still a little what curbs appetite naturally Sister Zhao to come Let's go together.Facing these people who quickest weight loss ever air, at first he suspected that herbal weight loss tablets projection technology, although this technology is on the earth. (cherrycreeknutrition.com)
- what is the best weight loss supplement program very A talented escape room player, within ten minutes, he finally found the exit button with the elimination appetite control products. (cherrycreeknutrition.com)
- What is Decreased Appetite/Weight Loss? (chemoexperts.com)
- What does Decreased Appetite/Weight Loss look like? (chemoexperts.com)
- Who gets Decreased Appetite/Weight Loss? (chemoexperts.com)
- In other cases, the most common approach to addressing weight loss is to increase appetite and therefore increase the total amount of calories that are eaten per day to make up for the increase in calories that are being used up by the body. (chemoexperts.com)
- It may only have a mild effect of stimulating appetite and can cause excessive drowsiness. (chemoexperts.com)
- Buying Epinephrine Injection depressants reduce or completely eliminate appetite. (sprayflexsprayers.com)
- As a result, they can lose interest in cooking or eating food which can reduce their appetite. (thechannel46.com)
- However, being partly a depressant, weed can reduce the effects of Adderall. (drug.education)
- Adipex Retard 75mg is an appetite suppressant of a pharmacological group of amphetamines and phenethylamines. (bestsuppliermeds.com)
- Although any scientist will tell you that cannabis is hard to classify, most people tend to view it as a hallucinogen crossed with a depressant. (searchandrestore.com)
- 2) Hariyanto TI and Kurniawan A. Appetite problem in cancer patients: Pathophysiology, diagnosis, and treatment . (chemoexperts.com)
- his best over the counter appetite suppressant at gnc huanghuali so he pulled it out and replanted it earlier! (maplesmanagement.com)
- If you have been having trouble eating well, here is how to increase appetite for a healthier and happier life. (thechannel46.com)
- When the leptin-serotonin pathway is turned on in mice, the researchers found, appetite increases, the animals eat more, gain weight, and their bone mass increases. (nutritionreview.org)
- Though obese people produce high levels of leptin, they are resistant, or unresponsive, to its signals - instead, they operate in a false state of leptin deficiency, which increases serotonin - and thereby, appetite and bone mass. (nutritionreview.org)
- Dr. Karsenty and his colleagues were surprised to observe that increased serotonin in the brainstem also increased appetite in mice. (nutritionreview.org)
- Dr. Karsenty's team found that the appetite and bone pathways diverge once serotonin is released: one set of serotonin receptors turns on appetite, while a second increases bone mass accrual. (nutritionreview.org)
- Not particularly sympathetic about her weight problem, the doctor told her she had to diet, but to help her he would prescribe an appetite depressant, Dexedrine, to be taken before breakfast. (rxisk.org)
- Are there healthy supplements that can increase my metabolism and decrease my appetite, or something like that? (healthtap.com)
- Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. (pharmaffiliates.com)
- Finally, in April of 2010, my weight doctor said I needed to exercise, lose weight and give up my appetite suppressant because it was doing the opposite of my current anti depressant. (stopthethyroidmadness.com)
- Your emotional state affects appetite which in turns results in weight problems. (daveswordsofwisdom.com)
- We were so hopeful that the drug would jumpstart her appetite but it never did. (funfoodlife.com)
- Theoretically, one can imagine that a drug that blocks only the appetite receptors, but not the bone receptors, could help people lose weight without losing bone mass," Dr. Karsenty said. (nutritionreview.org)
- It also increases the appetite and boosts metabolism, keeping you attentive throughout the day. (thechannel46.com)
- The appetite suppressant contains fiber in large quantities. (iuventusmedcenter.com)
- In small quantities, depressants help people achieve levels of relaxation they may struggle to obtain naturally by slowing the central nervous system's functions. (ardurecoverycenter.com)
- People who are abusing depressants may speak slowly and slur their speech. (paracelsus-recovery.com)
- Here's another effective tip on how to gain appetite fast. (thechannel46.com)
- Kratom also works as an effective anti-depressant. (thebestfashion.co)