Myocardial Depressant Factor
The decrease in a measurable parameter of a PHYSIOLOGICAL PROCESS, including cellular, microbial, and plant; immunological, cardiovascular, respiratory, reproductive, urinary, digestive, neural, musculoskeletal, ocular, and skin physiological processes; or METABOLIC PROCESS, including enzymatic and other pharmacological processes, by a drug or other chemical.
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
A carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of ANXIETY DISORDERS, and also for the short-term management of INSOMNIA but has largely been superseded by the BENZODIAZEPINES. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603)
Central Nervous System Depressants
A short-acting barbiturate that is effective as a sedative and hypnotic (but not as an anti-anxiety) agent and is usually given orally. It is prescribed more frequently for sleep induction than for sedation but, like similar agents, may lose its effectiveness by the second week of continued administration. (From AMA Drug Evaluations Annual, 1994, p236)
Hypnotics and Sedatives
A tricyclic dibenzazepine compound that potentiates neurotransmission. Desipramine selectively blocks reuptake of norepinephrine from the neural synapse, and also appears to impair serotonin transport. This compound also possesses minor anticholinergic activity, through its affinity to muscarinic receptors.
Therapeutic introduction of ions of soluble salts into tissues by means of electric current. In medical literature it is commonly used to indicate the process of increasing the penetration of drugs into surface tissues by the application of electric current. It has nothing to do with ION EXCHANGE; AIR IONIZATION nor PHONOPHORESIS, none of which requires current.
Muscle Relaxants, Central
A heterogeneous group of drugs used to produce muscle relaxation, excepting the neuromuscular blocking agents. They have their primary clinical and therapeutic uses in the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. They have been used also for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in MULTIPLE SCLEROSIS. (From Smith and Reynard, Textbook of Pharmacology, 1991, p358)
Dose-Response Relationship, Drug
A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178)
The domestic cat, Felis catus, of the carnivore family FELIDAE, comprising over 30 different breeds. The domestic cat is descended primarily from the wild cat of Africa and extreme southwestern Asia. Though probably present in towns in Palestine as long ago as 7000 years, actual domestication occurred in Egypt about 4000 years ago. (From Walker's Mammals of the World, 6th ed, p801)
Arthropods of the order Scorpiones, of which 1500 to 2000 species have been described. The most common live in tropical or subtropical areas. They are nocturnal and feed principally on insects and other arthropods. They are large arachnids but do not attack man spontaneously. They have a venomous sting. Their medical significance varies considerably and is dependent on their habits and venom potency rather than on their size. At most, the sting is equivalent to that of a hornet but certain species possess a highly toxic venom potentially fatal to humans. (From Dorland, 27th ed; Smith, Insects and Other Arthropods of Medical Importance, 1973, p417; Barnes, Invertebrate Zoology, 5th ed, p503)
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
A peptide, of about 33 amino acids, secreted by the upper INTESTINAL MUCOSA and also found in the central nervous system. It causes gallbladder contraction, release of pancreatic exocrine (or digestive) enzymes, and affects other gastrointestinal functions. Cholecystokinin may be the mediator of satiety.
The act of breathing with the LUNGS, consisting of INHALATION, or the taking into the lungs of the ambient air, and of EXHALATION, or the expelling of the modified air which contains more CARBON DIOXIDE than the air taken in (Blakiston's Gould Medical Dictionary, 4th ed.). This does not include tissue respiration (= OXYGEN CONSUMPTION) or cell respiration (= CELL RESPIRATION).
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Glucagon-Like Peptide 1
A peptide of 36 or 37 amino acids that is derived from PROGLUCAGON and mainly produced by the INTESTINAL L CELLS. GLP-1(1-37 or 1-36) is further N-terminally truncated resulting in GLP-1(7-37) or GLP-1-(7-36) which can be amidated. These GLP-1 peptides are known to enhance glucose-dependent INSULIN release, suppress GLUCAGON release and gastric emptying, lower BLOOD GLUCOSE, and reduce food intake.
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Thermogenic effects of sibutramine and its metabolites. (1/354)1. The thermogenic activity of the serotonin and noradrenaline reuptake inhibitor sibutramine (BTS 54524; Reductil) was investigated by measuring oxygen consumption (VO2) in rats treated with sibutramine or its two pharmacologically-active metabolites. 2. Sibutramine caused a dose-dependent rise in VO2, with a dose of 10 mg kg(-1) of sibutramine or its metabolites producing increases of up to 30% that were sustained for at least 6 h, and accompanied by significant increases (0.5-1.0 degrees C) in body temperature. 3. Based on the accumulation in vivo of radiolabelled 2-deoxy-[3H]-glucose, sibutramine had little or no effect on glucose utilization in most tissues, but caused an 18 fold increase in brown adipose tissue (BAT). 4. Combined high, non-selective doses (20 mg kg(-1)) of the beta-adrenoceptor antagonists, atenolol and ICI 118551, inhibited completely the VO2 response to sibutramine, but the response was unaffected by low, beta1-adrenoceptor-selective (atenolol) or beta2-adrenoceptor-selective (ICI 118551) doses (1 mg kg(-1)). 5. The ganglionic blocking agent, chlorisondamine (15 mg kg(-1)), inhibited completely the VO2 response to the metabolites of sibutramine, but had no effect on the thermogenic response to the beta3-adrenoceptor-selective agonist BRL 35135. 6. Similar thermogenic responses were produced by simultaneous injection of nisoxetine and fluoxetine at doses (30 mg kg(-1)) that had no effect on VO2 when injected individually. 7. It is concluded that stimulation of thermogenesis by sibutramine requires central reuptake inhibition of both serotonin and noradrenaline, resulting in increased efferent sympathetic activation of BAT thermogenesis via beta3-adrenoceptor, and that this contributes to the compound's activity as an anti-obesity agent. (+info)
Use of dexfenfluramine, fenfluramine and phentermine and the risk of stroke. (2/354)AIMS: To estimate the incidence of newly diagnosed idiopathic stroke among users of fenfluramine, dexfenfluramine and phentermine compared to obese nonusers. METHODS: We conducted a cohort study with nested case-control analysis utilizing data from the General Practice Research Database in the UK. Eight thousand four hundred and twenty-three subjects aged 69 years or less at the start of follow-up were exposed to at least one of the three study drugs and 17 225 similarly obese subjects were not exposed to any of the study drugs. RESULTS: We identified 45 incident cases of idiopathic CVA in this cohort of subjects. The incidence of CVA among all current users of a diet drug was 1.3/1000 person-years (95% CI 0.5, 3.5). The incidence for current fenfluramine users (n=2) was 2.6/1000 person-years (95% CI 0.7, 9.6), for current dexfenfluramine users (n=1) 1.1/1000 person-years (95% CI 0.3, 3.8), and for current phentermine users 0/1000 person-years (95% CI 0.0, 12.9). The incidence in obese nonusers was 0.6/1000 person-years (95% CI 0.4, 0. 9). The adjusted matched odds ratio (OR) for thrombotic stroke from the case-control analysis comparing current use of a diet drug to nonuse was 2.4 (95% CI 0.6, 9.1). There was only one exposed subject among seven who had haemorrhagic stroke. CONCLUSIONS: The incidence of CVA in generally young obese subjects during use of fenfluramine, dexfenfluramine or phentermine is low. Although we found an OR of 2. 4 comparing users of any of the anorexiants with nonusers, this is based on only three exposed cases and the confidence limits are wide. We conclude that our study does not support a substantial increased risk of stroke attributable to the use of fenfluramine, dexfenfluramine or phentermine. (+info)
Amphetamine and fenproporex levels following multidose administration of fenproporex. (3/354)Drugs that are metabolized to amphetamine or methamphetamine are potentially of significant concern in the interpretation of positive drug-testing results for amphetamines. A number of different drugs have been reported to produce amphetamine in the urine of users. One of these compounds, fenproporex, has been shown to be metabolized to amphetamine, and previous reports indicated the parent compound could be detected at low levels for up to 48 h. Administration of fenproporex for seven days (one 10-mg dose per day) to five healthy volunteers resulted in amphetamine being detected in the urine of all subjects. Peak concentrations of amphetamine ranged from approximately 2850 to 4150 ng/mL. Amphetamine could be detected (> or = 5 ng/mL) in the urine for up to nearly 170 h after the last dose. Analysis of the metabolically produced amphetamine showed the presence of both enantiomers, which can be helpful in the differentiation of some illicit amphetamine use from the use of this precursor drug. In addition, evaluation of the enantiomeric composition of the metabolite (amphetamine) can be a valuable tool in the interpretation of time since last dose. More significantly, all samples that contained amphetamine at a concentration of > or = 500 ng/mL were shown to also contain detectable amounts of the parent compound. (+info)
Pharmacologic induction of weight loss to treat type 2 diabetes. (4/354)OBJECTIVE: Most individuals with type 2 diabetes are overweight, and weight loss for them is an important therapeutic objective. However, usual weight-loss strategies have generally not produced sustained weight loss. Pharmacologic agents to assist weight loss might be useful, but no long-term data on their effectiveness and safety in patients with type 2 diabetes are available. We therefore initiated a 2-year placebo-controlled trial of the weight-loss medications fenfluramine and phentermine in type 2 diabetic subjects. RESEARCH DESIGN AND METHODS: A total of 44 overweight (> 120% ideal body weight) subjects with type 2 diabetes were enrolled in a randomized, placebo-controlled, double-blind trial of fenfluramine and phentermine. All subjects received intensive nutrition counseling, an exercise prescription, and instruction in behavior modification. Subjects were randomly assigned to 20 mg fenfluramine three times a day and 37.5 mg phentermine daily (n = 23) or dual placebos (n = 21). Diabetes medications were adjusted as necessary to achieve glycemic goals. Changes in weight, glycemia, lipemia, and blood pressure were assessed every 2 months, as were adverse events. In September 1997, when fenfluramine was withdrawn from the U.S. market, fenfluramine was stopped in all subjects. Thus the length of drug treatment varied, but 16 subjects (8 in each group) reached 12 months of treatment. Only data obtained before the withdrawal of fenfluramine are included in this report. RESULTS: A study termination, diabetes medications had been reduced in 1 subject in the placebo group (5%) and 11 subjects in the drug treatment group (52%) (P = 0.005). Drug treatment resulted in significant reductions in body weight, BMI, and HbA1c at all time points through 6 months. Changes in weight at 6 months were -2.7 +/- 1.4 kg (mean +/- SEM) with placebo treatment and -9.6 +/- 1.5 kg with drug treatment (P = 0.003). Even though more subjects in the drug treatment group required reductions in diabetes medications, at 6 months, changes in HbA1c were -0.3 +/- 0.2% with placebo treatment and -1.6 +/- 0.3% with drug treatment (P = 0.002). Fasting plasma glucose and triglycerides were significantly reduced at some time points with drug treatment. No serious adverse events attributable to study medications were observed. CONCLUSIONS: Premature study termination decreased the power of our study at later time points. However, our data suggest that weight loss medications are an effective treatment for type 2 diabetes during active weight loss. Whether the benefit persists after weight loss has stopped remains to be determined. (+info)
Continuous subcutaneous infusion of glucagon-like peptide 1 lowers plasma glucose and reduces appetite in type 2 diabetic patients. (5/354)OBJECTIVE: The gut hormone glucagon-like peptide 1 (GLP-1) has insulinotropic and anorectic effects during intravenous infusion and has been proposed as a new treatment for type 2 diabetes and obesity. The effect of a single subcutaneous injection is brief because of rapid degradation. We therefore sought to evaluate the effect of infusion of GLP-1 for 48 h in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: We infused GLP-1 (2.4 pmol.kg-1.min-1) or saline subcutaneously for 48 h in randomized order in six patients with type 2 diabetes to evaluate the effect on appetite during fixed energy intake and on plasma glucose, insulin, glucagon, postprandial lipidemia, blood pressure, heart rate, and basal metabolic rate. RESULTS: The infusion resulted in elevations of the plasma concentrations of intact GLP-1 similar to those observed after intravenous infusion of 1.2 pmol.kg-1.min-1, previously shown to lower blood glucose effectively in type 2 diabetic patients. Fasting plasma glucose (day 2) decreased from 14.1 +/- 0.9 (saline) to 12.2 +/- 0.7 mmol/l (GLP-1), P = 0.009, and 24-h mean plasma glucose decreased from 15.4 +/- 1.0 to 13.0 +/- 1.0 mmol/l, P = 0.0009. Fasting and total area under the curve for insulin and C-peptide levels were significantly higher during the GLP-1 administration, whereas glucagon levels were unchanged. Neither triglycerides nor free fatty acids were affected. GLP-1 administration decreased hunger and prospective food intake and increased satiety, whereas fullness was unaffected. No side effects during GLP-1 infusion were recorded except for a brief cutaneous reaction. Basal metabolic rate and heart rate did not change significantly during GLP-1 administration. Both systolic and diastolic blood pressure tended to be lower during the GLP-1 infusion. CONCLUSIONS: We conclude that 48-h continuous subcutaneous infusion of GLP-1 in type 2 diabetic patients 1) lowers fasting as well as meal-related plasma glucose, 2) reduces appetite, 3) has no gastrointestinal side effects, and 4) has no negative effect on blood pressure. (+info)
Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats. (6/354)The effect of the 5-hydroxytryptamine (5-HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)- or muscimol-injected rats. Sibutramine dose-dependently reduced feeding caused by food-deprivation (ED50 = 5.1+/-0.8 mg kg(-1)) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED50 = 6.0+/-0.5 mg kg(-1)). The increase in food intake caused by muscimol injected into the dorsal raphe was not modified by sibutramine (1-10 mg kg(-1)). The hypophagic effect of 5.1 mg kg(-1) sibutramine in food-deprived rats was studied in rats pretreated with different serotonin receptor antagonists. Metergoline (non-selective, 0.3 and 1.0 mg kg(-1)), ritanserin (5-HT2A/2C, 0.5 and 1.0 mg kg(-1)) and GR127935 (5-HT1B/1D), 0.5 and 1.0 mg kg(-1)) did not modify the hypophagic effect of sibutramine, while SB206553 (5-HT2B/2C, 5 and 10 mg kg(-1)) slightly but significantly reduced it (Fint(2.53) = 3.4; P<0.05). The reduction in food intake caused by 6.0 mg kg(-1) sibutramine in NPY-injected rats was not modified by GR127935 (1.0 mg kg(-1)). The results suggest that, with the possible exception of a partial involvement of 5-HT2B/2C receptors in sibutramine's hypophagia in food-deprived rats, 5-HT1 and 5-HT2 receptor subtypes do not play an important role in the hypophagic effect of sibutramine, at least in the first 2 h after injection. (+info)
Aminorex, fenfluramine, and chlorphentermine are serotonin transporter substrates. Implications for primary pulmonary hypertension. (7/354)BACKGROUND: Coadministration of phentermine and fenfluramine (phen/fen) effectively treats obesity and possibly addictive disorders. The association of fenfluramine and certain other anorexic agents with serious side effects, such as cardiac valvulopathy and primary pulmonary hypertension (PPH), limits the clinical utility of these drugs. Development of new medications that produce neurochemical effects like phen/fen without causing unwanted side effects would be a significant therapeutic breakthrough. METHODS AND RESULTS: We tested the hypothesis that fenfluramine (and other anorexic agents) might increase the risk of PPH through interactions with serotonin (5-HT) transporters. Because 5-HT transporter proteins in the lung and brain are identical, we examined, in rat brain, the effects of selected drugs on 5-HT efflux in vivo and monoamine transporters in vitro as a generalized index of transporter function. Our data show that drugs known or suspected to increase the risk of PPH (eg, aminorex, fenfluramine, and chlorphentermine) are 5-HT transporter substrates, whereas drugs that have not been shown to increase the risk of PPH are less potent in this regard. CONCLUSIONS: We speculate that medications that are 5-HT transporter substrates get translocated into pulmonary cells where, depending on the degree of drug retention, their intrinsic drug toxicity, and individual susceptibility, PPH could develop as a response to high levels of these drugs or metabolites. Emerging evidence suggests that it is possible to develop transporter substrates devoid of adverse side effects. Such medications could have therapeutic application in the management of obesity, drug dependence, depression, and other disorders. (+info)
The promotion effect of anorectic drugs on aflatoxin B(1)-induced hepatic preneoplastic foci. (8/354)The ability of three extensively used anorectic drugs, namely fenfluramine (FN), fluoxetine (FX) and amphetamine (AM), to alter the development of aflatoxin B(1) (AFB(1))-induced gamma-glutamyl-positive (GGT(+)) preneoplastic liver foci was investigated in 135 male weanling F344 rats. Following AFB(1) administration, 15 rats were killed, while the rest were divided into four groups and fed diets containing either FN, FX, AM or control diet, with half of the animals in each group subsequently being killed at 4 weeks and half at 10 weeks. All three anorectic drugs as expected suppressed initial food intake, growth rate, body weight gain and food efficiency. They also tended to suppress body fat mass and to decrease plasma levels of T(3) and T(4). FN significantly (P < 0.05) increased GGT(+) foci number/cm(2) and number/cm(3), while FX significantly increased GGT(+) foci number/cm(2) and the volume fraction of foci. Histopathological staining also revealed that FN- and FX-treated animals had more serious morphological alterations in their liver tissue. In contrast, foci development was, if anything, suppressed by AM feeding. These results indicate that serotoninergic drugs (FN and FX), as opposed to dopaminergic drugs (AM), may have tumor promoter activity, at least for liver tissue. (+info)
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The following are listed as appetite depressants by MeSH, an index of medical journal articles and books. ... An anorectic or anorexic is a drug which reduces appetite, resulting in lower food consumption, leading to weight loss. By ... The term is (from the Greek ἀν- (an-) = "without" and ὄρεξις (órexis) = "appetite"), and such drugs are also known as ... Most common natural appetite suppressants are based on Hoodia, a genus of 13 species in the flowering plant family Apocynaceae ...
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StimulantSuppressantsSuppressantStimulantsSide-effects of taking anti-deprObesityPrescribeRegulationSuppressionSuppress appetiteFenfluramineHypothalamusAnxietyLoss of appetMedicationAnti-DepreDrugsDecreaseDepressionAnorexigenicMedicationsNauseaMoodMeSHMirtazapineZoloftPhenylpropanolamineHumansConstipationTabletsTherapeuticDrugEffectsInsomniaFood intakeIntakeChemicalsPrescriptionsHungerSexualConsumptionDosesRegulateWeightBoost
- Diethylpropion is a sympathomimetic stimulant drug marketed as an appetite suppressant. (pharmacycode.com)
-  By contrast, an appetite stimulant is referred to as orexigenic . (wikipedia.org)
- Along with difficulty falling asleep at night (see below), loss of appetite is the most common side effect of stimulant meds. (additudemag.com)
- For reasons that remain poorly understood, some children who experience a loss of appetite while taking one stimulant medication experience no such loss on another. (additudemag.com)
- He also prescribe an anti-depressant/appetite stimulant. (agingcare.com)
- 89 yr old father steadily starving himself refusing to eat and I have more Dr appts coming up for him and being told no such thing as an appetite stimulant? (agingcare.com)
- Computer graphics space-filling representation of an amphetamine molecule, a drug with stimulant and appetite-depressant properties. (sciencephoto.com)
- In the low doses obtained in this way, the drug acts as a stimulant and an appetite depressant with physiological effects similar to those of tobacco . (encyclopedia.com)
- A person who is taking a stimulant may feel alert and confident, while a person who is taking a depressant may feel calm and free of mental stress. (wisegeek.com)
- geekish - There are a wide variety of inhalants so unfortunately there is not an easy way to label them, but they can most definitely known to be both depressant and stimulant inhalants. (wisegeek.com)
- Ephedra is used in diet products as an appetite depressant and stimulant, and in sports drinks to mask fatigue. (sci-toys.com)
- Mirtazapine, a tricyclic depressant for humans, has been shown to have appetite stimulant benefits for cats. (catwatchnewsletter.com)
- It is also a potent anti-emetic and appetite stimulant. (lortsmith.com)
- Low sex drive can be caused by several factors like low testosterone, depression , blood pressure medications like beta blockers and diuretics, use of anti depressants like Zoloft, Prozac and others, Megace ( an appetite stimulant), etc. (thebody.com)
- Its mechanism of action is similar to other appetite suppressants such as sibutramine, phentermine and dextroamphetamine. (pharmacycode.com)
- Physicians who used appetite suppressants often prescribed them for only four to six weeks which was inappropriate in the management of a chronic condition. (clinicaltrials.gov)
- The current article aimed to summarize recent concerns on the safety and efficacy of appetite suppressants. (scielosp.org)
- Several appetite suppressants have been banned for safety reasons. (scielosp.org)
- So far no study with a sufficiently large sample size has demonstrated that appetite suppressants can reduce morbidity and mortality associated with overweight. (scielosp.org)
- Used on a short-term basis clinically to treat obesity , some appetite suppressants are also available over-the-counter . (wikipedia.org)
- Most common natural appetite suppressants are based on Hoodia , a genus of 13 species in the flowering plant family Apocynaceae, under the subfamily Asclepiadoideae. (wikipedia.org)
- Several appetite suppressants are based on a mix of natural ingredients, mostly using green tea as its basis, in combination with other plant extracts such as fucoxanthin , found naturally in seaweed. (wikipedia.org)
- Numerous pharmaceutical compounds are marketed as appetite suppressants. (wikipedia.org)
- Are appetite suppressants effective? (healthtap.com)
- Appetite suppressants can help to reduce hunger to some degree. (healthtap.com)
- Are appetite suppressants helpful for losing weight? (healthtap.com)
- What are natural appetite suppressants? (healthtap.com)
- Do herbal life supplements really contain appetite suppressants? (healthtap.com)
- There are no effective over the counter appetite suppressants. (healthtap.com)
- Should I use cough drops as appetite suppressants? (healthtap.com)
- The class of medications used most often for weight loss are commonly referred to as "appetite suppressants. (minddisorders.com)
- All but two of the prescription appetite suppressants in the United States have been approved by the U.S. Food and Drug Administration (FDA), for short-term use only. (minddisorders.com)
- Synephrine, the active ingredient of bitter orange extract, exhibits similar appetite suppressant and stimulating properties as ephedra. (thefreedictionary.com)
- How could a single agent classified as an appetite suppressant exert significant effects in three such disparate domains? (thefreedictionary.com)
- From makeshift venues such as hotels, hairdressers' shops and beauty salons they sold the powerful appetite suppressant Duromine after it was withdrawn from the market because of undesirable side effects. (thefreedictionary.com)
- Dr Sudesh Madan prescribed the powerful appetite suppressant Duromine when Andrew Stott visited her dieting and slimming clinic in June last year, the Professional Conduct Committee in central London was told. (thefreedictionary.com)
- The best appetite suppressant in the world is the knowledge you might be getting your kit off and jumping into bed with a new man. (thefreedictionary.com)
- Diet pill or appetite suppressant use was noted in 72. (thefreedictionary.com)
- Phenylpropanolamine has been used as an appetite suppressant , and ephedra-type drugs are used in nutritional supplements for weight control as well as in many cough and cold formulas. (thefreedictionary.com)
- Harvesting a natural appetite suppressant from jojoba (pronounced ho-ho-bah) may give U. (thefreedictionary.com)
- Valvular heart disease has recently been reported to occur in association with the use of certain appetite suppressant medications. (thefreedictionary.com)
- Thus, dieters look to appetite suppressant medications as an easy "magic" way to their goal. (thefreedictionary.com)
- The term is (from the Greek ἀν- (an-) = "without" and ὄρεξις (órexis) = "appetite"), and such drugs are also known as anorexigenic , anorexiant , or appetite suppressant . (wikipedia.org)
- Indeed, amphetamine itself was sold commercially as an appetite suppressant until it was outlawed in most parts of the world in the late 1950s because of safety issues. (wikipedia.org)
-  Likewise, association of the related appetite suppressant phenylpropanolamine with hemorrhagic stroke led the Food and Drug Administration (FDA) to request its withdrawal from the market in the United States in 2000, and similar concerns regarding ephedrine resulted in an FDA ban on its inclusion in dietary supplements in 2004. (wikipedia.org)
- Dear appetite suppressant cause insomnia? (healthtap.com)
- Is glutamine an appetite suppressant? (healthtap.com)
- Doctor recommended appetite suppressant? (healthtap.com)
- Caffeine is indeed an appetite suppressant and can actually slightly increase your metabolism, and may have a modest effect on weight loss, but there is no hard evidence that caffeine will significantly lead to long term weight loss. (healthtap.com)
- What anti-depressant also has an appetite suppressant in it? (healthtap.com)
- Though not approved as an appetite suppressant , buproprion will work as one in addition to being an anti depressant. (healthtap.com)
- Appetite suppressant drugs (anorexients) are considered adjuncts to diet and behavior modification and exercise, and have traditionally been indicated only for short term use ( 4 ). (ispub.com)
- Pseudoephedrine: A Good Appetite Suppressant? (mindandmuscle.net)
- It not only promoted thermogensis in humans, but was a potent appetite suppressant. (mindandmuscle.net)
- In this article we will discuss the pharmaceutical properties of pseudoephedrine, restrictions on its purchase, and its use as an appetite suppressant. (mindandmuscle.net)
- Appetite-suppressant medications are drugs that promote weight loss by decreasing appetite or increasing the sensation of fullness. (minddisorders.com)
- One appetite suppressant medication was approved for longer-term use within the past decade, but that drug, dexfenfluramine (Redux) was withdrawn from the market because of unacceptable risks associated with its use. (minddisorders.com)
- This drug, an appetite suppressant, is called sibutramine (Meridia). (minddisorders.com)
- Orlistat is not an appetite suppressant, but rather, a member of a new class of anti-obesity drugs known as "lipase inhibitors. (minddisorders.com)
- What is the Difference Between Stimulants and Depressants? (wisegeek.com)
- The difference between stimulants and depressants is their effects on the body. (wisegeek.com)
- Stimulants and depressants are the exact opposite of each other. (wisegeek.com)
- Stimulants usually work to excite or arouse the body while depressants work to sedate it. (wisegeek.com)
- Stimulants can suppress appetites in those trying to lose weight. (wisegeek.com)
- There are many types of stimulants and depressants. (wisegeek.com)
- Additionally, anorectics are medications that are classified as stimulants and often used for appetite suppression. (wisegeek.com)
- Some of the stimulants and depressants a person may encounter are not traditionally used as medications. (wisegeek.com)
- Unfortunately, many of the substances that are used as stimulants or depressants are associated with a range of negative effects. (wisegeek.com)
- Lots of my friends love having coffee in the morning it must be on the top of the list of stimulants and depressants that are used often as well as alcohol for the depressant side of things. (wisegeek.com)
Side-effects of taking anti-depr1
- Erectile dysfunction and loss of orgasm are one of the main side-effects of taking anti-depressants. (ndtv.com)
- The prescription of amphetamines in the UK is controlled by law and usually restricted for use as an appetite depressant in people suffering from obesity. (sciencephoto.com)
- Some State medical boards allow physicians to prescribe appetite depressants for a maximum of 12 weeks out of the year regardless of successful management and benefits to the obese patient. (healthy.net)
- This can result in mood disorders and abnormal appetite regulation. (recoveryranch.com)
- This shows some of the appetite regulation pathways. (precisionnutrition.com)
- Why is appetite regulation important? (precisionnutrition.com)
- One of the best ways to grasp the importance of appetite regulation is to knock it out. (precisionnutrition.com)
- Major players in appetite regulation include insulin, thyroid hormone, glucagon like peptide-1 (GLP-1), endocannabinoids and cortisol. (precisionnutrition.com)
- In several relatively short term clinical trials (e.g., 16 weeks), it has been shown that appetite control medications such as fenfluramine and phentermine were more effective than placebo in inducing weight loss. (clinicaltrials.gov)
- In fact, the hypothalamus is the ringmaster of appetite, but there are lots of acts in the circus. (precisionnutrition.com)
- Some docs use it for anxiety and lack of appetite, but it does have some bad side effects. (medhelp.org)
- Too, decreased appetite with zoloft it uses direct such doctors that are n't second in any dropper with a results popular stress anxiety. (biometricsandbeyond.com)
- These groups treat disorders like eating disorders, bipolar, anxiety disorders, sedatives and even appetite suppressing conditions. (hubpages.com)
- Paxil, the famous anti-depressant that "cures" social anxiety, has side effects that cause a decrease in a person's IQ and discontinuation of Paxil has been known to cause a withdrawal syndrome that has led to several instances of suicide. (hubpages.com)
Loss of appet4
- Some ADHD medications can cause sleeplessness, loss of appetite, tics, and other side effects that no child should have to tolerate. (additudemag.com)
- Loss of Appetite. (additudemag.com)
- Anorexia also known as Anorexia Nervosa is a psychological and possibly life-threatening eating disorder which is characterized by an extremely low body weight relative to stature [this is called BMI (Body Mass Index)] with loss of appetite, illogical fear of weight gain, a strong desire to be thin and a distorted perception of self-image and body. (biogetica.com)
- Anti-depressants may lead to headache, loss of appetite, constipation, cramps in the abdomen and a metallic taste in the mouth. (biogetica.com)
- There may be little you can do to boost your child's appetite in the middle of the day (when medication is at maximum effectiveness). (additudemag.com)
- Treatment for bulimia or binge eating disorder will usually include anti-depressant medication and cognitive therapy. (recoveryranch.com)
- In answer to your question about other types of depressant drugs, I don't know many but I do know: Barbiturates (often these are prescribed medication for anesthesia and sedations) are another type of depressant drug and Gamma Hydroxybutyric Acid (interestingly this depressant is actually a treatment for narcolepsy) is a depressant as well. (wisegeek.com)
- Since cats who have a decreased appetite can develop life-threatening conditions such as hepatic lipidosis, this medication can have important uses in cats. (catwatchnewsletter.com)
- In medication to buying that you should do some emesis work yourself here of relying on a decreased appetite with zoloft paid embarrassment. (biometricsandbeyond.com)
- The findings of the study are significant because millions of Americans receive prescriptions for anti-depressant medication and the conventional wisdom is that these drugs are safe and effective. (bigthink.com)
- Anti-depressant drugs are not prescribed or taken at our facility but are routinely prescribed at many other treatment facilities around the country. (heroinaddiction.com)
- Below are listed some of the country's more popularly prescribed anti-depressant drugs along with their potential (and commonly reported) side effects and adverse reactions, categorized according to their type. (heroinaddiction.com)
- After performing a meta-analysis of past patient studies into the effects of anti-depressants, researchers at McMaster University have concluded that anti-depressant drugs, which work by regulating the chemical serotonin, do more harm than good when considering the drug's overall effect on a person's health. (bigthink.com)
- The following list of anti-depressant drug side effects and adverse reactions may serve as an important informational resource for those considering a regimen of such drugs. (heroinaddiction.com)
- In Colorado, for example, state prison officials are administering anti-depressants to offenders to study the drugs' effects on reducing their sexual appetites. (go.com)
- Should anti-depressants be used to help come off of drugs? (lavistachurchofchrist.org)
- Agent that is used to decrease appetite. (ebi.ac.uk)
- If the problem persists, don't delay taking action - especially if the appetite loss is severe enough to trigger decrease in total body mass, or, in a growing child, failure to grow appropriately. (additudemag.com)
- The effect appears to be caused by a reduction in appetite, and preventing the metabolic rate decrease usually associated with a reduced calorie diet. (sci-toys.com)
- Depression is one the common problems in today's time and many of us take high-doses of anti-depressants tablets and medications to calm our senses down and improve our mental health. (ndtv.com)
- Depression is also a common non-motor symptom of PD which can manifest as decreased appetite and food intake. (apdaparkinson.org)
- A person, who was lying down on the point of death, when given this plant, rises and has much energy and is free of depression and has a good appetite. (rexresearch.com)
- The only ci days evidence lot hold the such depression of zoloft with appetite decreased a con by a zoloft, real likely reported by the such sjs. (biometricsandbeyond.com)
- If a disturbed mental state is diagnosed, the doctor will recommend anxiolytics or anti-depressants if depression has set in. (biogetica.com)
- This signaling results in inhibition of downstream anorexigenic proopiomelanocortin (POMC)-positive neurons in a GABA-dependent manner, which then leads to appetite stimulation and a drive to accumulate adiposity and body weight. (nih.gov)
- Orexigenic means appetite-stimulating, while anorexigenic means appetite-suppressing. (precisionnutrition.com)
- But medications can also cause severe side effects, including headaches, sleep problems, and a blunted appetite. (additudemag.com)
- For example, barbiturates, tranquilizers , and benzodiazepines are among the medications that are used for their depressant qualities. (wisegeek.com)
- These medications promote weight loss by helping to diminish appetite, and/or by increasing the subjective feeling of fullness. (minddisorders.com)
- The following are listed as appetite depressants by MeSH , an index of medical journal articles and books. (wikipedia.org)
- Last time he was on mirtazapine, it increased his appetite, as many anti-depressants do. (pitbulltalk.com)
- Can anyone give names of any "antidepressants and or appetite stimulate" I guess a combo med or simply an appetite stimulate as already on 25 mg Zoloft which doesn't seem strong enough? (agingcare.com)
- Or is decreased appetite with zoloft it very an such fase if the need withdrawal appears in let' inhibitors? (biometricsandbeyond.com)
- Mostly a decreased appetite with zoloft fuller harvesting of this prevention's behaviors would say that zoloft, there in - with serotonin, is reviews now emotional for deze particles in symptoms and deformations - but at drug pharmacies that may consequently be financial. (biometricsandbeyond.com)
- Helpfulim back bijwerkingen is decreased appetite with zoloft is sense drug. (biometricsandbeyond.com)
- Knowing the zoloft with appetite decreased effects of day is independent to active helping you get the important accurate email, since oral people can make therapy worse. (biometricsandbeyond.com)
- Another internucleotide about this' sertralina' night is due to decreased appetite with zoloft valid medicines of adhd, sale but only carefully passing out. (biometricsandbeyond.com)
- The weight is miserable, and zoloft with appetite decreased serotonin reveals a similar, painful, physical bijwerkingen obstructing the trattamento. (biometricsandbeyond.com)
- It is similar in form to the appetite control drug phenylpropanolamine (now banned in the U.S.), also known as norephedrine , meaning ephedrine whose methyl group has been replaced by a hydrogen. (sci-toys.com)
- Furthermore, we found that obese humans and mice had pathologically elevated concentrations of circulating asprosin, and neutralization of asprosin in the blood with a monoclonal antibody reduced appetite and body weight in obese mice, in addition to improving their glycemic profile. (nih.gov)
- In conclusion, the results show that GLP-1 enhanced satiety and reduced energy intake and thus may play a physiological regulatory role in controlling appetite and energy intake in humans. (nih.gov)
- According to health experts, people who take heavy dose of anti-depressants have constipation and other related gastric ailments. (ndtv.com)
- Über therapeutische Erfahrungen mit dem Appetitzügler Eventin" [Therapeutic experiences with the appetite depressant eventin]. (wikipedia.org)
- Phenmetrazine is a sympathomimetic drug used primarily as an appetite depressant. (pharmacycode.com)
- An anorectic or anorexic is a drug which reduces appetite , resulting in lower food consumption, leading to weight loss . (wikipedia.org)
- What is occurring in street drug start is anorexic nervous appetite. (biometricsandbeyond.com)
- Read on to know about the lesser-known side-effects of anti-depressants. (ndtv.com)
- Take the time to understand anti-depressant side effects and the potential adverse reactions which can occur, before taking them. (heroinaddiction.com)
- marijuana has some of the effects of a depressant but can also be classified as a hallucinogen. (wisegeek.com)
- Negative side effects of anti-depressants disrupt these processes and can cause premature death in elderly patients. (bigthink.com)
- Anti-depressant calms your senses but heavy doses can disturb your sleep routine which can lead to insomnia or sleep deprivation. (ndtv.com)
- When stressed, appetite levels may increase and result in an increase of food intake. (definitions.net)
- We examined the effect of intravenously infused glucagon-like peptide 1 (GLP-1) on subjective appetite sensations after an energy-fixed breakfast, and on spontaneous energy intake at an ad libitum lunch. (nih.gov)
- Appetite exists in all higher life-forms, and serves to regulate adequate energy intake to maintain metabolic needs. (definitions.net)
- Most work by increasing levels of serotonin or catecholamine, chemicals in the brain that control appetite. (thefreedictionary.com)
- Anti-depressants disturbs the digestion process because the chemicals tend to interfere with the normal body mechanism. (ndtv.com)
- We're still learning about new pathways and chemicals involved in appetite, but below is a list of what we've got so far. (precisionnutrition.com)
- Paxil has over twenty million prescriptions in the United States alone, making it the fifth most prescribed anti-depressants in the country. (hubpages.com)
- The research determined that women who went bare back were more likely to become depressed following the breakdown of a relationship or sustained sexual liaisons, and also seek new sexual partners as soon as possible to, what can be interpreted as, help satisfy her insatiable appetite for come. (thefword.org.uk)
- A serious thirst, an increase in appetite especially for something sweet (which is called 'Munchies'), aggression, light headedness and forgetfulness in certain users are caused, especially when it is used together with the consumption of alcohol. (lavistachurchofchrist.org)
- Therefore, it is important that we minimize taking heavy doses of anti-depressants to avoid such problems. (ndtv.com)
- Serotonin and norepinephrine work to regulate certain functions in the mind and body including appetite, emotions, and sleep. (recoveryranch.com)
- While anti-depressants work to regulate serotonin in the brain, the chemical is found more plentifully in other parts of the body where it helps with processes like digestion and development. (bigthink.com)
- If so, getting him to cut back should boost his appetite for more nutritious fare. (additudemag.com)