Dibenzoquinolines derived in plants from (S)-reticuline (BENZYLISOQUINOLINES).
A plant genus of the family ANNONACEAE. Members contain asarone, isoguattouregidine (an isoquinoline alkaloid), norlaureline, puterine, noraporphine alkaloids.
The custard-apple plant family of the order Magnoliales, subclass Magnoliidae, class Magnoliopsida. Some members provide large pulpy fruits and commercial timber. Leaves and wood are often fragrant. Leaves are simple, with smooth margins, and alternately arranged in two rows along the stems.
A group of related plant alkaloids that contain the BERBERINE heterocyclic ring structure.
The rotation of linearly polarized light as it passes through various media.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
A plant genus of the family ANNONACEAE. It has edible fruit and seeds which contain acetogenins and benzoquinazoline and other alkaloids.
A plant genus of the family LAURACEAE. Members contain laurotetanine and other APORPHINES.
A plant genus of the family MONIMIACEAE. Members contain boldine ALKALOIDS. Some PEUMUS species have been reclassified as CRYPTOCARYA.
A plant genus of the family MAGNOLIACEAE. Members include hardwood trees of eastern North America with distinct large tuliplike flowers.
Organic nitrogenous bases. Many alkaloids of medical importance occur in the animal and vegetable kingdoms, and some have been synthesized. (Grant & Hackh's Chemical Dictionary, 5th ed)
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Agents destructive to the protozoal organisms belonging to the suborder TRYPANOSOMATINA.
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Infections with unicellular organisms formerly members of the subkingdom Protozoa.
A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi.
An order of flagellate protozoa. Characteristics include the presence of one or two flagella arising from a depression in the cell body and a single mitochondrion that extends the length of the body.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
A group of ISOQUINOLINES in which the nitrogen containing ring is protonated. They derive from the non-enzymatic Pictet-Spengler condensation of CATECHOLAMINES with ALDEHYDES.
A derivative of morphine that is a dopamine D2 agonist. It is a powerful emetic and has been used for that effect in acute poisoning. It has also been used in the diagnosis and treatment of parkinsonism, but its adverse effects limit its use.
Agents that cause vomiting. They may act directly on the gastrointestinal tract, bringing about emesis through local irritant effects, or indirectly, through their effects on the chemoreceptor trigger zone in the postremal area near the medulla.
A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.
The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.
Databases devoted to knowledge about PHARMACEUTICAL PRODUCTS.
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
The metabolism of drugs and their mechanisms of action.
Poisoning by the ingestion of plants or its leaves, berries, roots or stalks. The manifestations in both humans and animals vary in severity from mild to life threatening. In animals, especially domestic animals, it is usually the result of ingesting moldy or fermented forage.
The variety of all native living organisms and their various forms and interrelationships.
The systematic arrangement of entities in any field into categories classes based on common characteristics such as properties, morphology, subject matter, etc.
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
A province of eastern Canada. Its capital is Quebec. The region belonged to France from 1627 to 1763 when it was lost to the British. The name is from the Algonquian quilibek meaning the place where waters narrow, referring to the gradually narrowing channel of the St. Lawrence or to the narrows of the river at Cape Diamond. (From Webster's New Geographical Dictionary, 1988, p993 & Room, Brewer's Dictionary of Names, 1992, p440)
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
A feeling of restlessness associated with increased motor activity. This may occur as a manifestation of nervous system drug toxicity or other conditions.
A publication issued at stated, more or less regular, intervals.
Individual's rights to obtain and use information collected or generated by others.
Those support services other than room, board, and medical and nursing services that are provided to hospital patients in the course of care. They include such services as laboratory, radiology, pharmacy, and physical therapy services.
The use of statistical methods in the analysis of a body of literature to reveal the historical development of subject fields and patterns of authorship, publication, and use. Formerly called statistical bibliography. (from The ALA Glossary of Library and Information Science, 1983)
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.

Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes. (1/80)

1. Selective phosphodiesterase 4 (PDE4) inhibitors are of potential interest in the treatment of asthma. We examined the effects of the alkaloid S-(+)-glaucine, a PDE4 inhibitor, on human isolated bronchus and granulocyte function. 2. Glaucine selectively inhibited PDE4 from human bronchus and polymorphonuclear leukocytes (PMN) in a non-competitive manner (Ki=3.4 microM). Glaucine displaced [3H]-rolipram from its high-affinity binding sites in rat brain cortex membranes (IC50 approximately 100 microM). 3. Glaucine inhibited the spontaneous and histamine-induced tone in human isolated bronchus (pD2 approximately 4.5). Glaucine (10 microM) did not potentiate the isoprenaline-induced relaxation but augmented cyclic AMP accumulation by isoprenaline. The glaucine-induced relaxation was resistant to H-89, a protein kinase A inhibitor. Glaucine depressed the contractile responses to Ca2+ (pD'2 approximately 3.62) and reduced the sustained rise of [Ca2+]i produced by histamine in cultured human airway smooth muscle cells (-log IC50 approximately 4.3). 4. Glaucine augmented cyclic AMP levels in human polymorphonuclear leukocytes challenged with N-formyl-Met-Leu-Phe (FMLP) or isoprenaline, and inhibited FMLP-induced superoxide generation, elastase release, leukotriene B4 production, [Ca2+]i signal and platelet aggregation as well as opsonized zymosan-, phorbol myristate acetate-, and A23187-induced superoxide release. The inhibitory effect of glaucine on superoxide generation by FMLP was reduced by H-89. 5. In conclusion, Ca2+ channel antagonism by glaucine appears mainly responsible for the relaxant effect of glaucine in human isolated bronchus while PDE4 inhibition contributes to the inhibitory effects of glaucine in human granulocytes. The very low PDE4/binding site ratio found for glaucine makes this compound attractive for further structure-activity studies.  (+info)

Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis. (2/80)

1. In a recent in vivo study, liriodenine, an aporphine alkaloid, has been identified as a prominent anti-arrhythmic agent that can prevent rats' sudden deaths, even at the dose as low as 10(-7) g kg(-1). The aim of this study was to determine whether liriodenine at its effective anti-arrhythmic dose of 10(-7) g kg(-1) had effects on the left ventricular (LV)-arterial coupling in Wistar rats. 2. LV pressure and ascending aortic flow signals were recorded to construct the ventricular and arterial end-systolic pressure-stroke volume relationships to calculate LV end-systolic elastance (E(es)) and effective arterial volume elastance (E(a)), respectively. The optimal afterload (Q(load)) determined by the ratio of E(a) to E(es) was used to measure the optimality of energy transmission from the left ventricle to the arterial system. 3. Liriodenine at the dose of 10(-7) g kg(-1) showed no significant changes in basal heart rate (HR), cardiac output (CO), LV end-systolic pressure (P(es)), E(a), E(es), and Q(load). 4. By contrast, liriodenine at the dose of 10(-6) g kg(-1) produced a significant fall of 2.0% in HR and a significant rise of 5.8% in CO, but no significant change in P(es). Moreover, liriodenine administration of 10(-6) g kg(-1) to rats significantly decreased E(es) by 8.5% and E(a) by 10.6%, but did not change Q(load). 5. We conclude that liriodenine at the dose of 10(-7) g kg(-1) has no effects on the mechanical properties of the heart and the vasculature and the matching condition for the left ventricle coupled to its vasculature in rats. Even at 10 times the effective anti-arrhythmic dose, liriodenine shows no effects on the efficiency of energy transferred from the left ventricle to the arterial system.  (+info)

Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation. (3/80)

AIM: Dicentrine is a known alpha 1-adrenoceptor antagonist, but its alpha 1-adrenoceptor subtype selectivity has not yet been determined. We therefore, investigated the putative alpha 1-adrenoceptor subtype selectivity of this agent. METHODS: Graded isometric contractile responses of rat aortic rings and spleen to phenylephrine were observed in the absence or presence of various concentrations of dicentrine. The pA2 values for dicentrine were determined. RESULTS: Aortic tissues were more sensitive to phenylephrine-induced contraction than the spleen tissues. Dicentrine was approximately 100 times more potent as an antagonist to the aortic contraction, than it was to the splenic contractions. CONCLUSION: Dicentrine is an alpha 1-adrenoceptor antagonist which is more selective towards the putative alpha 1D-adrenoceptor subtype of the rat aorta than the alpha 1B-adrenoceptor of the spleen.  (+info)

Multiple actions of glaucine on cyclic nucleotide phosphodiesterases, alpha 1-adrenoceptor and benzothiazepine binding site at the calcium channel. (4/80)

1. In the present study, the properties of glaucine (an aporphine structurally related to papaverine) were compared with those of papaverine, diltiazem, nifedipine and prazosin. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination of the affinity of glaucine at calcium channel binding sites of alpha-adrenoceptors, by use of [3H]-(+)-cis-diltiazem, [3H]-nitrendipine and [3H]-prazosin binding to cerebral cortical membranes. The effects of glaucine on the different molecular forms of cyclic nucleotide phosphodiesterases (PDE) isolated from bovine aorta were also determined. 2. Contraction evoked by noradrenaline (1 microM) or depolarizing solution (60 mM KCl) were inhibited in a concentration-dependent manner by all the compounds tested. As expected, prazosin showed a greater selectivity of action on NA-induced contraction, whereas nifedipine and diltiazem appeared more potent on KCl-induced contraction. Glaucine had a greater potency on the contraction elicited by noradrenaline whereas papaverine acted non specifically. 3. In Ca(2+)-free solution, prazosin (0.1 microM) and glaucine (0.1 mM) inhibited the contraction evoked by NA; diltiazem (0.1 mM) diminished this contraction whereas nifedipine (1 microM) had no effect. Preincubation of tissues with glaucine, diltiazem, nifedipine and prazosin did not modify the contractile response induced by caffeine. In contrast, papaverine (0.1 mM) significantly inhibited the contractions evoked by NA or caffeine in Ca(2+)-free medium. 4. Glaucine and papaverine show affinity at the [3H]-prazosin binding site and at the benzothiazepine binding site of the Ca(2+)-channel receptor complex, but have no effect at the dihydropyridine binding site in rat cerebral cortex. Glaucine exerts some selectivity as an inhibitor of [3H]-prazosin binding as opposed to [3H]-(+ )-cis-diltiazem binding while papaverine appears to have approximately equal affinity in this respect.5. This study confirms the presence of four phosphodiesterase (PDE) activities in bovine aorta: a calmodulin-activated PDE (CaM-PDE type I) which hydrolyzed preferentially guanosine 3':5'-cyclic monophosphate (cyclic GMP); a cyclic GMP selective form (cGMP-PDE type V); and two low Km adenosine 3':5'-cyclic monophosphate (cyclic AMP) PDEs that are insensitive to the stimulatory effect of CaM, one of which was inhibited by cyclic GMP (CGI-PDE, type III) and the other by rolipram (cAMP-PDE, type IV). Glaucine selectively inhibits one of the two forms of Ca2+-independent low Km cAMP-PDE, the type IV. In contrast, papaverine exerts a non-selective inhibitory effect upon all PDE forms.6. The present work provides evidence that glaucine, a benzyltetrahydroisoquinoline alkaloid, has interesting properties as an alpha l-adrenoceptor antagonist, calcium entry blocker (through the benzothiazepine recognition site in the calcium channel) and as a selective inhibitor of the rolipram-sensitive cAMP-PDE, type IV PDE.  (+info)

Haemodynamic effects of dicentrine, a novel alpha 1-adrenoceptor antagonist: comparison with prazosin in spontaneously hypertensive and normotensive Wistar-Kyoto rats. (5/80)

1. The haemodynamic effects of dicentrine, an aporphine derivative isolated from the plant Lindera megaphylla, were investigated and compared with prazosin in rats. 2. In anaesthetized normotensive Wistar-Kyoto (WKY) rats, i.v. administration of dicentrine (0.1, 0.5, 1.0 mg kg-1) and prazosin (0.01, 0.05, 0.1 mg kg-1) induced a dose-related reduction of mean arterial pressure (MAP) which reached a maximal effect 5-10 min after injection and persisted for 2 h. 3. In anaesthetized WKY rats, a higher dose of dicentrine (1.0 mg kg-1, i.v.) did not cause any significant changes in heart rate (HR), cardiac output (CO) and stroke volume (SV) but markedly increased tail blood flow. In contrast, a higher dose of prazosin (0.1 mg kg-1, i.v.) produced a decrease in HR which paralleled the time course of the hypotensive response. 4. The hypotensive activity of dicentrine was completely abolished by alpha-adrenoceptor blockade. Both dicentrine and prazosin significantly attenuated pressor responses to noradrenaline but failed, even at maximal hypotensive doses, to impair the pressor effects of angiotensin II or vasopressin. These observations suggest that dicentrine appears to exert its hypotensive action through alpha 1-adrenoceptor blockade. 5. In conscious normotensive and spontaneously hypertensive (SH) rats, dicentrine (0.5-2.0 mg kg-1, i.v.) and prazosin (0.05-0.2 mg kg-1, i.v.) also evoked dose-related decreases in MAP which were of greater magnitude in SH rats. Oral administration of dicentrine (5 and 8 mg kg-1) to conscious SH rats caused a hypotensive effect which persisted for over 15 h.6. These results suggest that dicentrine may have therapeutic potential as an oral antihypertensive drug via alpha-adrenoceptor blockade.  (+info)

Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine. (6/80)

Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved.  (+info)

Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. (7/80)

Angiotensin-II (Ang-II) has inflammatory activity and is involved in different diseases associated with the cardiovascular system. This study has evaluated the effect of boldine (B), and two phenanthrene alkaloids semisynthesized by us, secoboldine (SB) and boldine methine (BM), on Ang-II-induced neutrophil recruitment. Intraperitoneal administration of 1 nM Ang-II induced significant neutrophil accumulation, which was maximal at 4-8 h. BM inhibited neutrophil infiltration into the peritoneal cavity at 4 h and 8 h by 73% and 77%, respectively, SB at 8 h by 55%, and B had no effect on this response. Although BM inhibited the release of cytokine-inducible neutrophil chemoattractant/keratinocyte-derived chemokine, macrophage inflammatory protein-2 (MIP-2), and platelet-activating factor (PAF) elicited by Ang-II, SB only reduced the release of MIP-2 after 4 h of its administration. Sixty-minute superfusion of the rat mesentery with 1 nM Ang-II induced a significant increase in the leukocyte-endothelial cell interactions and P-selectin up-regulation, which were inhibited by 1 microM BM and SB. The generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II was inhibited significantly by the three alkaloids tested. BM also diminished Ang-II-induced interleukin-8 release from endothelial cells and blocked the PAF receptor on human neutrophils (concentration of the compound needed to produce 50% inhibition value: 28.2 microM). Therefore, BM is a potent inhibitor of Ang-II-induced neutrophil accumulation in vivo. This effect appears to be mediated through inhibition of CXC chemokine and PAF release, ROS scavenging activity, and blockade of the PAF receptor. Thus, it may have potential therapeutic interest for the control of neutrophil recruitment that occurs in inflammation associated with elevated levels of Ang-II.  (+info)

Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori. (8/80)

Type II fatty acid synthesis (FAS II) is an essential process for bacteria survival, and malonyl-CoA:acyl carrier protein transacylase (MCAT) is a key enzyme in FAS II pathway, which is responsible for transferring the malonyl group from malonyl-CoA to the holo-ACP by forming malonyl-ACP. In this work, we described the cloning, characterization and enzymatic inhibition of a new MCAT from Helicobacter pylori strain SS1 (HpMCAT), and the gene sequence of HpfabD was deposited in the GenBank database (Accession No. AY738332 ). Enzymatic characterization of HpMCAT showed that the K(m) value for malonyl-CoA was 21.01+/-2.3 microM, and the thermal- and guanidinium hydrochloride-induced unfolding processes for HpMCAT were quantitatively investigated by circular dichroism spectral analyses. Moreover, a natural product, corytuberine, was discovered to demonstrate inhibitory activity against HpMCAT with IC(50) value at 33.1+/-3.29 microM. Further enzymatic assay results indicated that corytuberine inhibits HpMCAT in an uncompetitive manner. To our knowledge, this is the firstly reported MCAT inhibitor to date. This current work is hoped to supply useful information for better understanding the MCAT features of H. pylori strain, and corytuberine might be used as a potential lead compound in the discovery of the antibacterial agents using HpMCAT as target.  (+info)

Aporphines are a group of tetracyclic alkaloids that belong to the ubiquitous tetrahydroisoquinoline family. The aporphine template is known to be associated with a range of biological activities. Aporphines have been explored as antioxidants, anti-tuberculosis, antimicrobial and anticancer agents. Within the Central Nervous Systems (CNS), aporphine alkaloids are known to possess high affinity for several clinically valuable targets including dopamine receptors (predominantly D1 and D2), serotonin receptors (5-HT1A and 5-HT7) and α adrenergic receptors. Aporphines are also inhibitors of the acetylcholinesterase enzyme - a clinical target for the treatment of Alzheimers disease. Considering the diverse profile of aporphine alkaloids at CNS receptors they can be considered as
Pretreatment with thaliporphine before ischemia affords cardioprotective effects against reperfusion injury via antioxidant activity. This study evaluated whether thaliporphine administered at a certain period after myocardial ischemia conferred the same cardioprotection and assessed its possible new mechanism. The left main coronary artery of anaesthetized rats was occluded for 1 h and then reperfused for 2 h. Thaliporphine was administered at 10 min before reperfusion. Controls received saline only. Morphine, a nonselective opioid receptor agonist, was used as reference compound at 0.3 mg/kg. Thaliporphine at 0.05 and 0.5 mg/kg were found to reduce the infarct size. Recovery of cardiac function was higher in thaliporphine (0.5 mg/kg) group, as assessed by a significant improvement in the rates of pressure development (+dp/dt (max)). This compound also reduced plasma creatine kinase and cardiac MPO activity. These protective effects afforded by thaliporphine were diminished by the opioid receptor
What is Boldine? Where does Boldine Come From? Boldine Benefits, Bodybuilding, Side Effects, Safety, Dosage, Negatives, Supplements, When to Take Boldine..
Introduction: Boldine is an aporphine alkaloid that is found in high amount in boldo tree and Lindera aggregate. It is used as homeopathic and herbal medicine that has various antioxidant and anti-cancer. Our previous study has reported anti-telomerase effect of this alkaloid. In order to enhance this valuable inhibitory effect, ...
Isocorydine (ICD), an aporphine alkaloid, is widely distributed in nature. Its ability to target side population (SP) cells found in human hepatocellular carcinoma (HCC) makes it and its derivative 8-amino-isocorydine (NICD) promising chemotherapeutic agents for the treatment of HCC. To improve the anticancer activity of isocorydine derivatives, twenty derivatives of NICD were designed and synthesized through chemical structure modifications of the aromatic amino group at C-8. The anti-proliferative activities of all synthesized compounds against human hepatocellular (HepG2), cervical (HeLa), and gastric (MGC-803) cancer cell lines were evaluated using an MTT assay. The results showed that all the synthetic compounds had some tumor cell growth inhibitory activity. The compound COM33 (24) was the most active with IC50 values under 10?μM (IC50 for HepG2?=?7.51??M; IC50 for HeLa?=?6.32?μM). FICD (12) and COM33 (24) were selected for further investigation of their in vitro and in vivo activities ...
way the herb is usually simmered in water for 10-20 minutes before drinking. Some people like to infuse it into wine and then drink the wine. When prepared this way the herb is mixed with wine and allowed to infuse for anywhere from a few hours to a few weeks. The flowers contain the alkaloids aporphine and nuciferine as well as other related compounds. Some people like to smoke a mixture of blue lotus and cannabis (typically a 50:50 blend). ED POPPY FLOWER PETALS produce a mild sedative effect that is useful for treating anxiety and insomnia.. Some people like to infuse it into wine and then drink the wine. When prepared this way the herb is mixed with wine and allowed to infuse for anywhere from a few hours to a few weeks. The flowers contain the alkaloids aporphine and nuciferine as well as other related compounds. Some people like to smoke a mixture of blue lotus and cannabis (typically a 50:50 blend). ED POPPY FLOWER PETALS produce a mild sedative effect that is useful for treating anxiety ...
Title: Derivatives as 5HT1A Receptor Ligands-Past and Present. VOLUME: 12 ISSUE: 15. Author(s):G. Caliendo, V. Santagada, E. Perissutti and F. Fiorino. Affiliation:Dipartimento di Chimica Farmaceutica e Tossicologica, Via D. Montesano, 49, 80131 Naples, Italy.. Keywords:serotonin, neurotransmitter, g protein-coupled receptors, median raphe nucleus (mrn), ohdpat, enantioselectivity, indolylalkylamines, ergolines, aporphines, qsar. Abstract: Serotonin is a neuromediator, well-know for its implication in mood regulation, anxiety, depression and, insomnia as well as in normal human function such as sleep, sexual activity and appetite. In this way, serotonin (5-hydroxytryptamine, 5-HT) is one of the most attractive targets for medicinal chemists and pharmaceutical companies. Among 5-HTRs, the 5-HT1A subtype is the best studied, and it is generally accepted that it is involved in psychiatric disorders such as anxiety and depression. Several structurally different compounds are known to bind 5-HT1A ...
Product Name: NUCIFERINE Synonyms: (-)-nucipherine;(r)-1,2-dimethoxyaporphine;1,2-dimethoxy-6a-beta-aporphin;5,6,6a,7-tetrahydro-1,2-dimethoxy-6-methyl-g)quinolin(r)-4h-dibenzo(d;l-5,6-dimethoxyaporphine;l-nuciferine;nuciferin;NUCIFERINE CAS:...
Abstract In ischemia or ischemia-reperfusion (I/R), nitric oxide (NO) can potentially exert several beneficial effects. Thaliporphine, a natural alkaloid with Ca2+ channel-activating and Na+/K+ channel-blocking activities, increased NO levels and exerted cardioprotective action in ischemic or I/R rats. The role of NO in the cardioprotective actions of thaliporphine was assessed. The severity of rhythm disturbances and mortality in anesthetized rats with either coronary artery occlusion for 30 min, or 5 min followed by 30-min reperfusion, were monitored and compared in thaliporphine- vs. placebo-treated groups. Thaliporphine treatment significantly increased NO and decreased lactate dehydrogenase (LDH) levels in the blood during the end period of ischemia or I/R. These changes in NO and LDH levels by thaliporphine were associated with a reduction in the incidence and duration of ventricular tachycardia (VT) and ventricular fibrillation (VF) during ischemic or I/R period. The mortality of animals ...
Representative images and quantitative analysis of CAOV-3 cells treated or not treated with liriodenine at 24 hours.Notes: The cells were stained with Hoechst,
Liriodenine (L), an active component of the anticancer traditional Chinese medicine (TCM), was isolated from Zanthoxylum nitidum. Its reactions with Pt(II) and Ru(II) afforded three metal complexes: cis-[PtCl2(L)] (1), cis-[PtCl2(L)(DMSO)] (2), and cis-[RuCl2(L)(DMSO)(2)]center dot 1.5H(2)O (3), the crystal structures of L, 2 and 3 were determined by single-crystal X-ray diffraction methods. These complexes were fully characterized by elemental analysis, IR spectrophotometry, H-1 and C-13 NMR spectroscopies, and ES mass spectrometry. The in vitro cytotoxicity of L and complexes 1-3 against 11 human tumour cell lines was assayed. The metal-based compounds exhibit enhanced cytotoxicity vs. free L, suggesting that these compounds display synergy in the combination of metal ions and liriodenine. The binding properties of L and its complexes 1-3 to ct-DNA were investigated through UV-vis, fluorescence, CD spectra, viscosity and agarose gels electrophoretic measurements.. ...
Lotus leaf flavone nuciferine powder HACCP Kosher FDA factory 20% lotus leaf extract,US $ 1 - 300 / Kilogram, lotus leaf extract, Powder, Leaf.Source from Changsha World-Way Biotech Inc. on Alibaba.com.
Leishmaniasis and trypanosomiasis are protozoan diseases caused respectively by the kinetoplastid protozoan Leishmania parasites transmitted by the female phlebotomine sa..
Sigma-Aldrich offers abstracts and full-text articles by [Shuiying Zhang, Qian Zhang, Qiang Guo, Yunfang Zhao, Xiaoli Gao, Xingyun Chai, Pengfei Tu].
Sixteen compounds were extracted and purified from the leaves of Liriodendron tulipifera. These compounds include aporphines, oxoaporphine, coumarin, sesquiterpene lactone, benzenoids, cyclitol and steroids. (+)-Norstephalagine (2) (an aporphine) and scopoletin (8) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. The identified compounds were screened for their antiradical scavenging, metal chelating and ferric reducing power activities. The results have showed that these compounds have antioxidative activity. The study has also examined the chemopreventive property of the isolated compounds against human melanoma cells A375. The results shown that (−)-anonaine (1), (−)-liridinine (3), (+)-lirinidine (6), lysicamine (7) and epitulipinolide diepoxide (9) significantly inhibited the proliferation of melanoma cells. These results revealed that these compounds have antioxidative activity and chemopreventive activity in skin melanoma cells.
bulbocapnine: was heading 1975-94 (Prov 1975-90); use APORPHINES to search BULBOCAPNINE 1975-94 (as Prov 1975-94); alkaloid from Corydalis cava and other plants; induces catalepsy probably due to its antagonism of DOPAMINE
Nandina domestica is an evergreen Shrub growing to 2.5 m (8ft) by 2 m (6ft) at a medium rate. It is hardy to zone (UK) 7 and is not frost tender. It is in leaf 12-Jan It is in flower from Jun to July. The flowers are hermaphrodite (have both male and female organs)Suitable for: light (sandy), medium (loamy) and heavy (clay) soils and prefers well-drained soil. Suitable pH: acid, neutral and basic (alkaline) soils. It cannot grow in the shade. It prefers moist soil.
Two of the four parameters in the rule of five, molecular weight and log P, which can be detected and predicted by mass spectrometry and compound retention on reversed-phase HPLC, were used as guidelines in natural product isolation. A new aporphine alkaloid, (6aR)-normecambroline (1), was isolated from the bark of Neolitsea dealbata (R. Br.) Merr. Its structure was determined on the basis of NMR, MS and CD analysis. It is the first time the absolute configuration of the roemerine-N-oxide was assigned for both roemerine-N α-oxide (3) and roemerine-Nβ-oxide (4). Physico-chemical property evaluation demonstrated all alkaloids had no Lipinski violation. Compound 1 inhibited selectively against cervical cancer cells (HeLa) with an IC50 of 4.0 μM. © 2010 Elsevier Ltd. All rights reserved.
Reports of recreational use of glaucine have recently been published, and effects include dissociative-type symptoms; feeling detached and in another world, as well as nausea, vomiting and dilated pupils. These reports mirror those about the effects of clinical use, which state dissociative-type symptoms as well as lethargy, fatigue, hallucinations.[8][9] Investigation of side effects in a clinical setting also reports that the hallucinatory effects manifest as bright and colorful visualizations. They also report that patients perceive their environments clearly yet feel detached from it; the patient sees and understands everything and is oriented well enough, but cannot take a clear and adequate action.[8]. One particular report of recreational use gone awry described the form of distribution as tablets being marketed as a 1-benzylpiperazine (BZP)-free herbal high which the patient referred to as head candy.[9]. ...
Swedish teen climate activist Greta Thunberg hitched a renewable-energy ride back to Europe on Wednesday, sailing into the Atlantic on a trip she hopes will get her to Madrid in time for another climate conference, and then home for the holidays. Thunberg tweeted as she took to the sea on the 48-foot
Supplementary MaterialsSupplementary Movie 1 41598_2020_65742_MOESM1_ESM. 120?rpm and a pullback velocity of 50 m/s and 500 m/sec to achieve an interval between frames was 25 m and 250 m. Each Nuciferine blood vessel was also imaged using a conventional OCT system at the same position with the same frame interval (51.2k A-line rate with a rotation speed of 3000?rpm and pullback velocity of 1 1.25?mm/s and 12.5?mm/s) to allow direct comparison against the OCT. Intravascular OCT system, used in this study, was built based on a prototype device from a commercial OCT manufacturer (NinePoint Medical, Cambridge, MA, USA). The axial and lateral resolution, defined as FWHM of peak intensity at the focal plane, of the OCT system was 11.58 m and 22.67 m, respectively. Following imaging, the animal blood vessels were resected, fixed, and processed for histopathological analysis. All animal studies were approved by the Institutional Animal Care and Use Committee of Korea University College of Medicine ...
Lotus plumule is another type of Lotus flower that is far less famous than the Blue Lily and Blue Lotus flowers, but it has potent characteristics unique to itself. The main consituents, as expected, are nuciferine, but veterans and fans of Blue Lotus will notice a different energy about this tincture, especially because it is a Full Spectrum extract containing the entire energy signature of the plant, but in a stronger form that a straight hydrosol ...
Resumo: Introdução: Situações de doença aguda podem tornar-se crônicas, a exemplo das feridas, especialmente as úlceras venosas. Estas são definidas por lesões em membros inferiores relacionadas à insuficiência venosa e acometem os aspectos familiares, sociais e laborais. A Bota de Unna é uma tecnologia utilizada para o tratamento das úlceras venosas que constituem importante problema de saúde pública pela elevada incidência, prevalência, impacto socioeconômico, cronicidade e frequência das recidivas. Objetivos: Analisar a efetividade da tecnologia Bota de Unna no tratamento da úlcera venosa; caracterizar o perfil sócio demográfico e clínico dos pacientes com feridas crônicas; e mensurar a recidiva das úlceras venosas após tratamento com a tecnologia Bota de Unna. Método:Pesquisa retrospectiva documental realizada no Ambulatório de Tratamento de Feridas de um hospital de ensino de Curitiba-Paraná, no período de dois anos (2013-14), coleta de dados abrangeu o ...
Thousands of miles away from his impeachment trial in Washington, President Trump was in Davos where he pledged to plant join an initiative to plant trillion trees. Teen climate activist Greta Thunberg delivered her retort. Joe Davies reports.
Climate activist Greta Thunberg arrived in Madrid Friday to join thousands of other young people in a march to demand world leaders take real action against...
Wake County Public Schools says they have received no complaints over a mural of child climate activist Greta Thunberg and a quote by rapper Lil Nas X painted on the wall of a boys bathroom in Apex Friendship High School.
Fluorescent micrographs and quantitative analysis of CAOV-3 cells double-stained with acridine orange and propidium iodide. Cells were treated with liriodenine
A fine green leaf of the Nandina Plant makes an attractive choice for this hanging foliage. The plant sprays out the side to approximately 40cm in width but does not hang below the bottom of the pot. It is a delicate and mid-green house plant which will enhance any room. The brass planter measures 42cm in length from the top of the hanger to the base of the pot. It is held by 3 gold coloured chains with a metal ring at the top (please note: wall bracket or hook for hanging is not included). The width of the pot is 15cm. ...
Broncholytin information about active ingredients, pharmaceutical forms and doses by Sopharma, Broncholytin indications, usages and related health products lists
Among the activists and thinkers who are concerned about the increasing heat and instability of the climate there has been a long-running debate about what exactly motivates people to take action. Some say that a realistic form of hope backed with practical action works best, and that fear and despair are very disempowering, while others say that a good scare never did anyone any harm, and will get people off their butts. Sixteen year old Greta Thunberg told the worlds wealthy elite assembled at Davos in January 2019: Adults keep saying: we owe it to the young people to give them hope. But I dont want your hope. I dont want you to be hopehttp://Greta Thunberg told the worlds wealthy elite assembled at Davos in January 2019ful; I want you to panic. I want you to feel the fear I feel every day. And then I want you to act. I want you to act as you would in a crisis.. Thunberg suffered a deep depression before she decided that taking action was the way out of despair, and she is now doing a ...
Tratamento endovascular da doença venosa oclusiva central: experiência de um centro . Fernando Barbosa Trevisan ; Wander Eduardo Sardinha ; Domingos Moraes Filho ; Eduardo Durante Ramires ; Silfayner Victo. Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
The following are my personal views arising from The following are my personal views arising from Gretas words.On climate changeLike Greta, I am
Barrskogsförnamal, Hypatopa binotella (Thunberg, 1794), Förnamalar (Blastobasidae).Vingbredd: 19-21 mm. Flyger i maj,juni,juli,augusti,september.
Thalfoetines A-D (1-4), unique hybrid aporphine alkaloids with a C-7 aromatic unit formed by a new C-C bond linking two building blocks, were isolated from Thalictrum foetidum. Their structures were elucidated by extensive spectroscopic and computational analysis. They inhibited bacteria significantly, and compound 1 damaged the cell structure of Staphylococcus aureus and inhibited its DNA synthesis ...
This year has been so hard. It has been by far the most difficult despite everything we had already been through. Mae has been witness to too many traumatizing and devastating things. She has sat quietly as doctors have discussed infections, strokes, seizures, cancer, and terrible odds. She has seen her baby sister scream in pain. She has walked beside us the many times Phoebe has been transferred to the ICU. She has seen Jon and I completely broken. She has asked if Phoebe will ever come home. She has watched as Phoebe is sedated. She has wondered out loud if the Phoebe that she loves so much would come back to her after a stroke and fungal infection in the brain caused her to be unrecognizable. She has sat by and held her little sisters hand through days that would cause the strongest people to completely break down. Despite a fungal infection that has left marks and scars on Phoebes skin that are most likely permanent - Mae sees nothing but pure beautiful and brave Phoebe. Unlike some ...
Scene: Central Perk. All except Chandler, plus Emma.]. Phoebe: Oh hey you guys, I couldn t get a reservation for the night of my birthday, so we have to do dinner Thursday night instead.. Joey: Thursday? But that s Halloween.. Phoebe: So?. Joey: [It s just] So spooky, that s all.. Ross: So, so, is Mike coming to dinner?. Phoebe: No! It s my first birthday with a boyfriend, and he has to work. Uch, I get mad at him, but I think it s a little to soon to show my true colors.. Rachel: Pheebs, I would make a reservation for five, because one of us has to stay home and watch Emma. (to Ross:) Which one of us should go to dinner?. Phoebe: Oh, Rachel!. Ross: Actually, um, I was thinking maybe both of us could go.. Phoebe: Oh, yay!. Ross: Thanks, I put a lot of extra thoughts on your gift.. Phoebe: Alright, okay, so we can all go now. That is fun. Hey, you know what? We all haven t been together the six of us in such a long time.. Monica: What are you talking about? We re all together right now.. Rachel: ...
Papaver fugax Poiret population Khalkhal was shown to contain four major alkaloids, roemerine (0.19%), mecamberine (0.39%), liriodenine (0.20%) and salutaridine (0.10%). Papaver caucasicum M. B. population Elika was shown to contain four major alkaloids, nuciferine (0.50%), amurensinine (0.15%), lysicamine (0.30%) and nornuciferine (0.40%). Lysicarnine and nornuciferine were detected for the first time in Papaveraceae
Phoebes latest bone marrow chimerism shows that just 9% of her cells are donor cells and the remaining 91% are leukemia. This is slightly higher than on the last test. The leukemia is now predominantly AML, with some ALL still present. Phoebes blood and spinal fluid remain clear of leukemia and although the bone marrow results are terrible and devastating, Phoebe is not a sick little girl. She is eating, playing, laughing, singing and telling us exactly how she feels. She is often the last person to go to sleep and the first to wake up in the morning and she brings the joy and spunk to our days. She has earned the title of tiny boss lady because as joyful as she is, she is also very bossy and determined. At least once a day, I hear Mae tell Phoebe - you are not the boss of me. Phoebe has so little control over her days that she tries her best to control what she can, including Mae ... and Jon and I too. ...
The main event will be the lecture given by world-renown humanitarian child prodigy, Greta Thunberg - a recognized expert on multiple subjects including virology, ecology, public policy, epidemiology, climate science, and public health.. Thunbergs philosophical treatise on the balance between constitutional rights and public police measures within the context of global pandemics, Do it My Way, or Else, earned her an honorary doctorate awarded by the University of Cambridge.*. Dr. Thunberg was awarded Times Person of the Year award while also being nominated for a Nobel Peace Prize in 2019, (and one of Forbes 100 Most Powerful Women).. CNN announced Wednesday it will feature Dr. Greta Thunberg in its next Coronavirus: Facts and Fears town hall program set for Thursday night on the cable channel.. The town hall will be hosted by AC 360 anchor Anderson Cooper and CNN chief medical correspondent Dr. Sanjay Gupta.. The town hall on Thursday night comes one week after the network welcomed ...
Nandina (Nandina domestica), also known as heavenly bamboo, originates from Japan and belongs to the Berberis family. The evergreen, tender shrub produces un-branched limbs and deeply divided leaves ...
Recently, there has been interest in the antiarrhythmic potential of the novel antianginal agent, ranolazine, the first Food and Drug Administration-approved drug that specifically blocks the late component of the Na+ current. Like most antiarrhythmics that target cardiac ion channels (eg, flecainide and amiodarone), ranolazine blocks multiple channels, including the repolarizing hERG current IKr, with therapeutic concentrations. The result is a mild concentration-dependent QTc prolongation seen in patients with chronic stable angina.11 Because of this, ranolazine is contraindicated for patients using other QT-prolonging drugs, those with preexisting QT prolongation,12 and those with repolarization abnormalities.. In this study, we sought to use a computationally based approach to determine whether ranolazines unintended pathological block of promiscuous K+ channels would prevail over therapeutic drug effects in 2 specific patient populations: LQT3-ΔKPQ carriers and those with acquired ...
Lindera is cultivated for its attractive, aromatic foliage, star-shaped, mid-April flowers and showy red to black fruit. Growth habit is rounded with
Theres a lot to talk about when it comes to youth climate activist Greta Thunberg like her notable speeches calling out politicians or her appointment as Times person of the year. Instead, radio host and former Trump aide Sebastian Gorka decided…
Teenage climate activist Greta Thunberg accused political and business leaders of polishing their images rather than taking aggressive action in the fight against climate change at a United Nations summit on Wednesday. Lauren Anthony reports.
Los Angeles singer/songwriter Phoebe Bridgers stopped by the Paste studio on July 31 to perform a few tracks ahead of the release of her debut album, Stranger in the Alps . Bridges started off with Georgia from her 2015 EP Killer , then performed her two latest singles, Smoke Signals and Motion Sickness. Stranger in the Alps arrives September 22.
stranger in the alps by phoebe bridgers buy online at resident, ten soul-shattering songs of brutally honest lyrical unburdening worthy of keaton
THE X Factor is now a distant memory but Phoebe Brown, who battled through to the final stages of the contest with girl band Hope, has built on the groups success.
Introducción: La insuficiencia venosa crónica tiene alta incidencia en adultos, especialmente mujeres, el dolor es un síntoma característico, incluso después de cirugía. Se requiere identificar factores asociados al dolor en pacientes con insuficiencia venosa crónica previo y posterior al manejo con varicectomía. Métodos: Estudio observacional retrospectivo que evalúa la escala visual análoga de dolor de los pacientes con insuficiencia venosa crónica antes y después de intervención en un hospital de Bogotá. Las puntuaciones se analizaron basado en la diferencia entre los factores clínicos, sociodemográficos y quirúrgicos. Se utilizaron la prueba de Kruskal Wallis y el coeficiente de correlación de Spearman para el análisis. Resultados : Se incluyeron 307 pacientes con clasificación CEAP II y III. El 66% fueron mujeres y la edad promedio fue 47 años. Consultar por linfangitis se asoció a mayor dolor preoperatorio (p,0.001) y a mayor frecuencia de complicaciones y ...
Get this from a library! Selection, preparation, and pharmacological evaluation of plant material. [Elizabeth M Williamson; D T Okpako; Fred J Evans]
Hosagoudar, V. B., G. Rajkumar, C. K. Biju & T. K. Abraham. Amazonia goniothalami sp. nov. and some additional records of fungi on Goniothalamus wightii from India. Mycotaxon 77: 431-433. 2001.. ABSTRACT: An endemic plant, Goniothalamus wightii, was infected with four fungi. Of these, Amazonia gonioithalami was found to be an undescribed species; Trichasterina goniothalami is reported here in a new locality. Spiropes dorycarpus and S. guareicola are hyperparasites on these two fungi.. KEYWORDS: Amazonia, Trichasterina, Hyperparasites. NOMENCLATURAL NOVELTIES ...
The dextrorotary (R)-(+)-enantiomer is the most pharmacologically active, although a variety of related derivatives have been studied.[3] Side effects including chest pain (suggestive of possible cardiovascular toxicity) have been seen following recreational use of diphenylprolinol, although it was combined with glaucine in a party pill product, thus making it impossible to say for certain which drug was responsible.[4] ...
Thurs. 02.23.17 - For years I have used the word conuberation to mean a rather exuberant mashup of people or things or emotions as…. ...
Im 26, have had diabetes since I was 8, have been on a pump since 2000, and have been a nurse since January of 2011. My life is kind of crazy - but then again, so am I so it all works! I just moved to a new city in a new state for a new job, so theres a lot to figure out in addition to the usual stuff that requires figuring. Join me on my crazy journey through life as a nurse with diabetes.. ...
You know how you meet little old ladies, who see you with your child, and they smile and say Enjoy this, they grow up so fast! I always smile and nod and say Oh I understand. Because they mean well, and theyre right - 3 out of 4 times. I dont say Well, THIS one…
You know how you meet little old ladies, who see you with your child, and they smile and say Enjoy this, they grow up so fast! I always smile and nod and say Oh I understand. Because they mean well, and theyre right - 3 out of 4 times. I dont say Well, THIS one…
Has anyone gone off Remicade out of choice and then returned to it later on? Hi everyone, I hope you are all well. I thought it was about time I posted, since I havent been on the forums for such a long time! Things with me are good… Im working way too much, to the point.... ...
I honestly think the best part, though, may be that Simon is like a different dog. Hes always been terrified of strangers, yet on one of our lengthy lets-wear-out-the-puppy walks this week he walked up to a complete stranger to say hello, and allowed said stranger to pat his head. I have never ever ever seen him do anything like it. Hes no longer at all anxious in the car (although Phoebe is still barfing any time shes in a moving vehicle for more than 10 minutes). Hes no longer whining in his crate. His appetite has returned. Hes happily trotting along next to Phoebe on walks with the double leash, and no longer jumping at every sound. Its like someone flipped a neuroses off switch in the dim recesses of his fuzzy little brain. I so desperately hope it lasts ...
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Aug. 19, 2019 - The Jupiter-Saturn Conjunction Brings Economic Shift; Hong Kong Fights for Independence; Great Thunberg and the UN Climate Summit
Phoebe is being released from the hospital tomorrow. She has done pretty well with this round of chemo, but it was discovered that she has unrinary tract infection. I am glad they finally figured out what was bothering her. She had complained that her bottom was hurting for about 2 weeks but we could never…
Embolia crônica e trombose da veia poplítea direita icd 10. Sinais de trombose venosa profunda no pé. PAtologia - Doenças vasculares , cardíacas e pulmonares Icd da 10 veia e embolia direita trombose crônica poplítea, 5 principais veias do corpo.
January 1976). "Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10- ... Miller RJ, Kelly PH, Neumeyer JL (January 1976). "Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in ... N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine. In rodents it has ... and analogous aporphines". Neuropharmacology. 21 (10): 953-61. doi:10.1016/0028-3908(82)90106-X. PMID 6890636. Argiolas A, ...
Extracts of bioactive molecules from its tissues have been reported to contain aporphine derivatives. "Annona acuminata Saff". ... Borup-Grochtmann, I.; Kingston, David G. I. (1982). "Aporphine Alkaloids From Annona acuminata". Journal of Natural Products. ...
Stévigny C, Block S, De Pauw-Gillet MC, de Hoffmann E, Llabrès G, Adjakidjé V, Quetin-Leclercq J. Cytotoxic aporphine alkaloids ... I. New aporphine alkaloids fromCassytha filiformisL". Australian Journal of Chemistry. 19 (2): 297. doi:10.1071/CH9660297. ISSN ... "Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA ...
... is an anti-cholinergic aporphine alkaloid. Naaz, H; Singh, S; Pandey, VP; Singh, P; Dwivedi, UN (2013). "Anti- ...
The most common structural types are the benzylisoquinolines and the aporphines. According to current knowledge, a total of ...
Bandara, BM; Cortes, D; Jayasinghe, UL; Karunaratne, V; Sotheeswaran, S; Wannigama, GP (1989). "Aporphine alkaloids from Litsea ...
Benzylisoquinoline alkaloids include aporphines and oxoaporphines, as well as derivatives of morphinans. Essential oils include ...
Aporphine is said to be main psychoactive compound present. Other compounds include apomorphine and nuciferine. In Southern ... Like other species in the genus, the plant contains the psychoactive alkaloid aporphine (not to be confused with apomorphine). ... Some evidence indicates the effects of plants including N. caerulea that contain the psychoactive alkaloid aporphine were known ...
Aporphines: Synthesis, Pharmacology, and Modeling of D2Aand 5-HT1AReceptor Interactions". Journal of Medicinal Chemistry. 39 ( ...
Miller RJ, Kelly PH, Neumeyer JL (1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain ... 1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines ...
Structurally, it contains an aporphine core featuring a quaternary ammonium group. Asimilobine - amine not quaternized Anonaine ... Pukateine Matsushige, A; Kotake, Y; Matsunami, K; Otsuka, H; Ohta, S; Takeda, Y (2012). "Annonamine, a new aporphine alkaloid ...
α ] D 20 = + 36.5 {\displaystyle [\alpha ]_{D}^{20}=+36.5} ° Aporphine Lakshmi; et al. (2009). "An Overview of Family ...
Apomorphine Aporphine Glaucine Bulbocapnine Nantenine Pukateine Stepholidine Tetrahydropalmatine Bhattacharya, S. K.; Bose, R ...
Matsushige, A; Kotake, Y; Matsunami, K; Otsuka, H; Ohta, S; Takeda, Y (2012). "Annonamine, a new aporphine alkaloid from the ... The leaves of Annona muricata contain annonamine, which is an aporphine-class alkaloid containing a quaternary ammonium group. ...
His main work was on nucleic acids, morphine and aporphine alkaloids. His work at University College Nottingham on ...
Both Nymphaea caerulea and Nelumbo nucifera contain the alkaloids nuciferine and aporphine.[citation needed] The genome of the ...
"Two New Natural Azafluorene Alkaloids and a Cytotoxic Aporphine Alkaloid from Polyalthia longifolia". Journal of Natural ...
Wu, YC; Duh, CY; Wang, SK; Chen, KS; Yang, TH (1990). "Two new natural azafluorene alkaloids and a cytotoxic aporphine alkaloid ...
Most important were the benzylisoquinoline-aporphine derivatives, a relatively new group of alkaloids. The results obtained ...
... is an aporphine alkaloid found in several different plant species in the family Papaveraceae such as Glaucium flavum, ... Zetler, G. (1988). "Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, ... Zetler G (1988). "Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, ...
For example, aporphine alkaloid liriodenine produced by the tulip tree protects it from parasitic mushrooms. In addition, the ...
It has been suggested that piperolactam A and related compounds are biosynthesised from aporphine precursors. Aristolactams ...
... aporphine, leonurine, nuciferine, and nicotine. Some synthetic cannabinoids products have also been found to contain synthetic ...
Azasteroid Aporphine Heterocyclic compound India portal Chemistry portal His adviser for master's degree was S. M. Mukherji ... Among the other natural products and drugs he synthesized include steroidal sapogenins, phenanthridine, aporphine, quinculidine ... for the synthesis of the phenanthridine ring system and other heterocyclic systems as well as the synthesis of aporphine and ...
S)-Magnoflorine is a quaternary benzylisoquinoline alkaloid (BIA) of the aporphine structural subgroup which has been isolated ... "Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid ...
Apomorphine - a related chemical used in the treatment of Parkinson's disease Aporphine - the core alkaloid Nuciferine ...
... is an alkaloid of the aporphine class that can be found in the boldo tree and in Lindera aggregata. Boldine has ...
In addition, benzoisoquinoline alkaloids found in the Sacred Lotus, including aporphine, proaporphine, and nuciferine, are ...
... also have alkaloids of the aporphine type, such as N-(cinnamoil)-tryptamine, lignans of the aryl-tetralin type, ...
Aporphine is an alkaloid with the chemical formula C 17H 17N. It is the core chemical substructure of the aporphine alkaloids, ... It can exist in either of two enantiomeric forms, (R)-aporphine and (S)-aporphine. Many different derivatives have been ... R)-Aporphine is a dopamine receptor D1 antagonist with a Ki of 717 nM and a dopamine receptor D2 antagonist with a Ki of 527 nM ... Some derivatives of aporphine such as (S)-(+)-N-propylnorapomorphine have potential as low side effect profile antipsychotics ...
The aporphine alkaloids are of interest mainly because of their similarity to morphine. The aporphine alkaloids are most ... At least 85 aporphine alkaloids have been isolated from plants of 15 families. The best known representative is apomorphine. ... The aporphine alkaloids usually have a stereocenter. The (R)-configured glaucine can be synthesized from (S)-glaucine. ... Aporphine alkaloids are naturally occurring chemical compounds from the group of alkaloids. After the benzylisoquinoline ...
... an aporphine alkaloid from -Enico-santhellum pulchrum, inhibits proliferation of human ovarian cancer cells through induction ... Liriodenine, an aporphine alkaloid from -Enico-santhellum pulchrum, inhibits proliferation of human ovarian cancer cells ... Mutagenicity of isoquinoline alkaloids, especially of the aporphine type. Mutat Res. 1990;240:267-279. ... Electrophysiological mechanisms for antiarrhythmic efficacy and positive inotropy of liriodenine, a natural aporphine alkaloid ...
Aporphine and tetrahydroprotoberberine alkaloids from the leaves of Guatteria friesiana (Annonaceae) and their cytotoxic ... The presence of aporphine and tetrahydroprotoberberine alkaloids in the leaves of G. friesiana is consistent with previous ... Aporphine and tetrahydroprotoberberine alkaloids isolated from the leaves of Guatteria friesiana (Annonaceae). ... 13 as well as aporphine alkaloids.8 The alkaloids and essential oils exhibited antitumor and antimicrobial properties,4,6-9 as ...
Aporphine alkaloids are its characteristic ingredients and responsible for its bioactivities, especially anti-inflammatory and ... The fragmentation pathways by loss of CO, ·CH3 , ·NH3 , and ·NH2 CH3 were detected as characteristic for aporphine alkaloids. ... The established method is simple, rapid, and specific for characterization and quantitation of aporphine alkaloids in Dou-chi- ... The quantification method was validated in terms of linearity, precision, and accuracy for six major aporphine alkaloids, which ...
The organic solvent extracts of M. crispat, M. brevipes and their isolated aporphines showed varied levels of activity against ... The oxoaporphines were generally the most active especially against L. donovani (14.59 ≤ IC50 ≥ 52.20 μm). The aporphine, (+)- ... Eleven aporphines alkaloids (Figure 1) identified as, (-)- mocrispatine (1); (-)-pallidine (2); (-) N-méthylarmépavine (3 ... The generally low antiprotozoal activity of the aporphines does not make them good candidates for either leishmaniasis or ...
en] Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine ... en] 3T3 Cells/drug effects ; Animals ; Aporphines/chemistry/pharmacology ; Female ; HL-60 Cells/drug effects ; Hela Cells/drug ...
Omar, H.; Hashim, N.M.; Zajmi, A.; Nordin, N.; Abdelwahab, S.I.; Azizan, A.H.S.; Hadi, A.H.A.; Ali, H.M. Aporphine alkaloids ... Results: Cinnamic acid (1) and two aporphine alkaloids (liridine (2) and lysicamine (3)) have been successfully purified and ... Title:Purification of Cinnamic Acid and Aporphine Alkaloids from Enicosanthellum pulchrum Twig Extract and their Biological ... Results: Cinnamic acid (1) and two aporphine alkaloids (liridine (2) and lysicamine (3)) have been successfully purified and ...
The aporphine template is known to be associated with a range of biological activities. Aporphines have been explored as ... Aporphines are also inhibitors of the acetylcholinesterase enzyme - a clinical target for the treatment of Alzheimers disease ... Within the Central Nervous Systems (CNS), aporphine alkaloids are known to possess high affinity for several clinically ... Considering the diverse profile of aporphine alkaloids at CNS receptors they can be considered as ...
Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity Aporphine alkaloids from Piper ... Full text: Available Index: LILACS (Americas) Main subject: Aporphines / Acetylcholinesterase / Plant Extracts / Cholinesterase ... Aporphines/pharmacology , Acetylcholinesterase/drug effects , Plant Extracts/chemistry , Cholinesterase Inhibitors/pharmacology ... Piper/chemistry , Alkaloids/pharmacology , Aporphines/chemistry , Terpenes/isolation & purification , Cholinesterase Inhibitors ...
Aporphine, 1,2,10-trimethoxy-, dl- - Similar structures search, synonyms, formulas, resource links, and other chemical ... Substance Name: Aporphine, 1,2,10-trimethoxy-, dl-. RN: 28277-71-6. InChIKey: RZERUPREKNWRRD-UHFFFAOYSA-N. ...
The Aporphines. I. Introduction II. A Classical Degradation of an Aporphine III. Apomorphine IV. Nonbiogenetic Syntheses of ... Ushinsunine: A C-7 Hydroxylated Aporphine XV. Steporphine: A C-4 Hydroxylated Aporphine XVI. The Dehydroaporphines References ... The Oxidation of Aporphines and the Reduction of Oxoaporphines. IV. An Unusual Demethoxylation Reaction V. Pharmacology VI. NMR ... The Aporphine-Benzylisoquinoline Dimers. I. Introduction II. Structural Elucidation and Synthesis III. Biosynthesis IV. ...
Structure of the pure constituent was determined by NMR technique and identified as aporphine. Aporphine from S. venosa showed ... Apoptotic Activity of Aporphine from Stephania venosa on Human Ovarian Cancer Cells. K. Montririttigri, P. Moongkarndi,* S. ... alkaloids, apoptosis, aporphine, cancer, caspase, DNA fragmentation, MTT assay, NMR, Stephania venosa, Ovarian Cancer Download ... Apoptotic Activity of Aporphine from Stephania venosa on Human Ovarian Cancer Cells ...
Aporphine. Aporphine Chemical structure of aporphine colspan=2 style="background:#f8eaba; border-top:2px solid transparent; ... Aporphine is a 5-HT1a partial agonist with a ki of 80nM and a 5-HT7 antagonist with a ki of 88nM.[2] Aporphine is a Dopamine D1 ... Aporphine is one of a class of quinoline alkaloids. Many different relatives of this compound have been purified from plants.[1 ... This page is based on the copyrighted Wikipedia article Aporphine; it is used under the Creative Commons Attribution-ShareAlike ...
Alkaloids from Cassytha filiformis and related aporphines : antitrypanosomal activity, cytotoxicity and interaction with DNA ... Home» Alkaloids from Cassytha filiformis and related aporphines : antitrypanosomal activity, cytotoxicity and interaction with ... Alkaloids from Cassytha filiformis and related aporphines : antitrypanosomal activity, cytotoxicity and interaction with DNA ...
New Analogues of Aporphine Alkaloids. , 2018; 18(19): 1590-1602.. Yi-Chao Ge and Kui-Wu Wang*. DOI: 10.2174/ ...
Miller RJ, Kelly PH, Neumeyer JL (1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain ... 1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines ...
Aquatic herbs, rhizomatous; mycorrhizae 0; latex, aporphine alkaloids +; radicle aborts; root stele polyarch; cork?; plant with ...
Aporphines and Alzheimers Disease: Towards a Medical Approach Facing the Future. Seyed Mohammad Nabavi, Eugenio Uriarte, Luca ...
Topics: Medicinal chemistry; Natural products; Photochemistry reactivity; Aporphines, oxoaporphines, and oxoisoaporphines; ... Topics: Medicinal chemistry; Natural products; Photochemistry reactivity; Aporphines, oxoaporphines, and oxoisoaporphines; ... Topics: Medicinal chemistry; Natural products; Photochemistry reactivity; Aporphines, oxoaporphines, and oxoisoaporphines; ...
For example, aporphine. alkaloid liriodenine produced by the tulip tree protects it from parasitic mushrooms. In. addition, the ... Aporphines [77]. Proaporphines [77]. Homoaporphines [92]. Homoproaporphines [92]. Morphines[93]. ipecoside [89]. Sanguinarine, ...
The very planar conformation of oxo-aporphine alkaloid 1 may account for its higher genotoxicity vs. its less-planar analogues ... 0 (Alkaloids); 0 (Analgesics, Opioid); 0 (Aporphines); 0 (Plant Extracts); 1HG84L3525 (Formaldehyde); 7V31YC746X (Chloroform); ...
Monimiaceae [Hernandiaceae + Lauraceae]]: aporphine alkaloids and variants +; (cork cambium outer cortical); crystals +, small ... about half of them are aporphine alkaloids (Conserva et al. 2005; see also J.-J. Chen et al. 2011). Their distributions show no ...
... aporphine); Luteanine; S-(+)-Isocorydine; 4H-Dibenzo(de,g)quinolin-11-ol, 5,6,6a,7-tetrahydro-1,2,10-trimethoxy-6-methyl-, (S ...
Aporphines. Sub Class. Not Available. Direct Parent. Aporphines. Alternative Parents. Phenanthrenes and derivatives / ... Aporphine / Benzoquinoline / Phenanthrene / 2-naphthol / 1-naphthol / Naphthalene / Quinoline / Tetrahydroisoquinoline / 1- ... This compound belongs to the class of organic compounds known as aporphines. These are quinoline alkaloids containing the ...
Aporphines. 1. 2014. 85. 0.040. Why? Chemokines. 1. 2019. 933. 0.040. Why? ...
Aporphine and protopine, which are isoquinoline alkaloids, have been found in Dicentra species. Several other alkaloids have ...
... is a aporphine alkaloid (CHEBI:134209) Synonym Source Boldine KEGG COMPOUND ...
... and aporphine, such as xylopine (Table 1). ...
Aporphines [D03.438.531.085.030]. *Apomorphine [D03.438.531.085.030.290]. *Heterocyclic Compounds with 4 or More Rings [D03.549 ...
  • Aporphine and its related alkaloids bulbocapnine, boldine, glaucine, and corytuberine are antipsychotic, exert naloxone-reversible antinociceptive activity, and with the exception of corytuberine are anticonvulsant. (wikipedia.org)
  • Study of butanol extract of leaves and twigs yielded two new aporphine alkaloids, namely litseglutine A and B, along with two known aporphine alkaloids, boldine and laurolitsine. (stuartxchange.org)
  • Isoquinoleinic alkaloids (0.2-0.5%): Boldo contains about 20 alkaloids derived from aporphine, the most important being boldine, which represents 25-30% of the total alkaloids. (botanical-online.com)
  • It contains 0.2% aporphine alkaloids with boldine as its main compound, as well as flavonols and their glycosides (boldoglucin and isorhamnetin). (ageless.co.za)
  • Aporphine and protopine, which are isoquinoline alkaloids, have been found in Dicentra species. (gc.ca)
  • Genus Phoebe have been reported to produce isoquinoline alkaloids as aporphines, noraporphines, and benzylisoquinolines. (phcogj.com)
  • Aporphine is hydroxylated in the body to form apomorphine. (wikipedia.org)
  • Apoglaziovine Apomorphine Bulbocapnine Corydine Glaucine Isoboldine Isothebaine Nuciferine The aporphine alkaloids differ in their substituents and their position on the base structure. (wikipedia.org)
  • [ 1 ] One commonly used aporphine derivative is apomorphine , although it does not occur naturally. (omicsgroup.org)
  • In the search for agents from tropical medicinal plants to treat these two neglected tropical diseases, serially extracted petroleum ether, dichloromethane and methanol extracts of the leaves of Monodora crispata and Monodora brevipes , and eleven aporphines alkaloids isolated from the dried powdered leaves of the two plants were evaluated against Leishmania donovani promastigotes and Trypanosoma brucei brucei trypomastigotes. (omicsonline.org)
  • Cytotoxic aporphine alkaloids from Cassytha filiformis. (uliege.be)
  • en] Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. (uliege.be)
  • This supports the idea that aporphine alkaloids are responsible for the plant's cytotoxic activity. (naturalnews.com)
  • Two new natural azaflu-orene alkaloids and a cytotoxic aporphine alkaloid from Poiyaithia longifolia . (springer.com)
  • Cerasoidine, a bis-aporphine alkaloid isolated from Poiyaithia cerasoides during screening for Wnt signal inhibitors. (springer.com)
  • Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. (medchemexpress.com)
  • The chromatographic conditions were optimized on a SinoChrom ODS-BP column to obtain a good separation of the four types of alkaloid analytes, including two aporphines (isocorydine, corydine), two protopines (protopine and allocryptopine), a morphine (sinoacutine), and three quaternary protoberberine alkaloids (berberrubine, 5-hydroxycoptisine, and berberine). (jove.com)
  • Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. (ac.ke)
  • Aporphine alkaloids are naturally occurring chemical compounds from the group of alkaloids. (wikipedia.org)
  • These compounds will further expand our understanding of the tolerance of the aporphine core required for 5-HT 2A antagonism. (cuny.edu)
  • Accordingly, there is a need in the art for new methods in addition to the linear skin incision model in rats which allow direct observations and measurements of wound-healing acceleration in taspine and taspinates and their aporphine-derived analogs and other aporphine-derived compounds. (google.com)
  • They were able to identify four major compounds, which were the aporphine alkaloids actinodaphnine, anonaine, isoboldine, and nornuciferine. (naturalnews.com)
  • The biosynthesis of these compounds has been of considerable interest due in large part to the inclusion of both an aryl carboxylic acid and an aryl nitro functionality (uncommon in natural products) within their structures, which suggested an apparent biogenetic relationship to the well-known aporphine alkaloids. (wikipedia.org)
  • In order to understand the structural tolerance of the aporphine core required for 5-HT 2A antagonism an exhaustive Structure Activity Relationship (SAR) study was designed.Accordingly, a diverse library of nantenine analogues was synthesized and evaluated for affinity at the 5-HT 2A receptor. (cuny.edu)
  • Based on results of these studies, it is concluded that the interaction of C3 halogenated aporphine analogues with Phe339/Phe340 residues might be responsible for their enhanced affinity. (cuny.edu)
  • These are analogues of Aporphines, where a nitrogen atom replaces the carbon atom at position 1, and a keto group at C7. (hmdb.ca)
  • Comparative assessment of dopamine agonist aporphines as anticonvulsants in two models of reflex epilepsy. (axonmedchem.com)
  • 14 Dopaminergic and antinociceptive activity of aporphine derivatives. (wikipedia.org)
  • The aporphine alkaloids are of interest mainly because of their similarity to morphine. (wikipedia.org)
  • The aporphine alkaloids are of particular interest because of their proximity to morphine and benzylisoquinoline alkaloids. (wikipedia.org)
  • From Croton chilensis, a monotypic species, morphine and aporphine alkaloids were obtained. (scielo.cl)
  • In vitro tests of some aporphine derivatives isolated from Cassytha filiformis, namely actinodaphnine, cassythine, and dicentrine, showed antiparasitic activity against Trypanosoma brucei. (wikipedia.org)
  • The aporphine alkaloid nantenine is a 5-HT 2A receptor antagonist and has moderate affinity for the 5-HT 2A receptor. (cuny.edu)
  • The aporphine core of nantenine serves as a valuable lead for the identification of selective 5-HT 2A antagonists. (cuny.edu)
  • Biochemically, magnoliids are characterized by the presence of benzylisoquinoline or aporphine alkaloids , which are secondary metabolites with a defensive function and are rare in other groups. (britannica.com)
  • 1976). „Aporphines. (wikipedia.org)
  • Cotzias GC, Papavasiliou PS, Tolosa ES, Mendez JS, Bell-Midura M (1976) Treatment of Parkinson's disease with aporphines. (springer.com)
  • Phylogenetic analysis was performed for each of 15 different enzyme/protein groupings, highlighting many novel genes with potential involvement in the formation of one or more alkaloid types, including morphinan, aporphine, and phthalideisoquinoline alkaloids. (beds.ac.uk)
  • Aporphines are also inhibitors of the acetylcholinesterase enzyme - a clinical target for the treatment of Alzheimer's disease. (cuny.edu)
  • The aporphine template is known to be associated with a range of biological activities. (cuny.edu)
  • The relative concentration of alkaloids and phenolics in boldo leaves and their activity suggest that free-radical scavenging effect is mainly due to catechin and flavonoids and that antioxidant effect is mainly related with the catechin content The high catechin content of boldo leaves and its bioactivity suggest that quality control of Boldo folium has to combine the analysis of catechin as well as their characteristic aporphine alkaloids. (worldwidescience.org)
  • Cassytha filiformis, a plant used in African traditional medicine, contains many aporphine alkaloids and that the three main alkaloids actinodaphnin, cassythin, and dicentrin have an in vitro effect on cancer cells. (wikipedia.org)
  • Some derivatives of aporphine such as (S)-(+)-N-propylnorapomorphine have potential as low side effect profile antipsychotics. (wikipedia.org)
  • In spite of this fairly broad variety of benzyltetrahydroisoquinolines and aporphines, the concentrations of these alkaloids in the different organs of C. alba are quite low, which is in contrast with the sometimes generous yields of alkaloids in this genus. (conicyt.cl)
  • Aporphine alkaloids are its characteristic ingredients and responsible for its bioactivities, especially anti-inflammatory and analgesic effects. (sigmaaldrich.com)
  • The fragmentation pathways by loss of CO, ·CH3 , ·NH3 , and ·NH2 CH3 were detected as characteristic for aporphine alkaloids. (sigmaaldrich.com)
  • The high catechin content of boldo leaves and its bioactivity suggest that quality control of boldo folium has to combine the analysis of catechin as well as their characteristic aporphine alkaloids. (sigmaaldrich.com)
  • For example, many water-lilies (Nymphaea species) produce aporphine alkaloids such as nymphaeine, nymphaline, nupharine, α- and β-nupharidine. (wikipedia.org)
  • Aporphines have been explored as antioxidants, anti-tuberculosis, antimicrobial and anticancer agents. (cuny.edu)
  • Finally, a novel series of flexible tris-(phenylalkyl)amines were synthesized and evaluated to test the importance of a rigid aporphine core as well as incorporation of N-phenylalkyl substituents. (cuny.edu)
  • Norstephalagine ( 2 ) (an aporphine) and scopoletin ( 8 ) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. (mdpi.com)
  • Aporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (mdpi.com)
  • 8 The composition and antimicrobial effect of the essential oil distilled from the very aromatic leaves has also been investigated by at least three independent groups, and is composed mainly of monoterpenoids such as terpin-1-en-4-ol, β-terpinene, 1,8-cineole (eucalyptol), p-cymene, α - and β-pinene. (conicyt.cl)
  • together with seven known sesquiterpenes including a new naturally-occurring lindenanolide H (4) and eight known aporphine alkaloids. (go.jp)
  • Aporphine is an alkaloid with the chemical formula C 17H 17N. (wikipedia.org)
  • It is the core chemical substructure of the aporphine alkaloids, a subclass of quinoline alkaloids. (wikipedia.org)
  • R)-Aporphine is a dopamine receptor D1 antagonist with a Ki of 717 nM and a dopamine receptor D2 antagonist with a Ki of 527 nM. (wikipedia.org)
  • Aporphine is a 5-HT1a partial agonist with a ki of 80nM and a 5-HT7 antagonist with a ki of 88nM. (omicsgroup.org)
  • [ 2 ] Aporphine is a Dopamine D1 antagonist with a ki of 717nM [ 3 ] and a dopamine D2 antagonist with a ki of 527nM. (omicsgroup.org)
  • The aporphine alkaloids are most commonly found in plants. (wikipedia.org)
  • The quantification method was validated in terms of linearity, precision, and accuracy for six major aporphine alkaloids, which was successfully applied for simultaneous determination in ten batches of samples. (sigmaaldrich.com)
  • Results: Cinnamic acid (1) and two aporphine alkaloids (liridine (2) and lysicamine (3)) have been successfully purified and identified. (eurekaselect.com)
  • At least 85 aporphine alkaloids have been isolated from plants of 15 families. (wikipedia.org)
  • Results from the morphological changes, DNA fragmentation and caspase activation assay, in this study demonstrated that aporphine could significantly inhibit the treated tumor cell proliferation and cause cells death via apoptosis, whereas those were not found in the untreated cells. (mahidol.ac.th)
  • BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells. (nih.gov)
  • Scientists attribute the family's wide range of pharmacological activities to acetogenins and isoquinolines, specifically aporphine alkaloids . (naturalnews.com)
  • The method by which the central aporphine ring structure is constructed in nature is exemplified by the biosynthesis of bulbocarpin. (wikipedia.org)
  • Aporphines are a group of tetracyclic alkaloids that belong to the ubiquitous tetrahydroisoquinoline family. (cuny.edu)