Guatteria
Annonaceae
Berberine Alkaloids
Magnetic Resonance Spectroscopy
Annona
Peumus
Liriodendron
Alkaloids
Oils, Volatile
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Trypanocidal Agents
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces "African sleeping sickness." Nagana is a rapidly fatal trypanosomiasis of horses and other animals.
Protozoan Infections
Leishmania
A genus of flagellate protozoa comprising several species that are pathogenic for humans. Organisms of this genus have an amastigote and a promastigote stage in their life cycles. As a result of enzymatic studies this single genus has been divided into two subgenera: Leishmania leishmania and Leishmania viannia. Species within the Leishmania leishmania subgenus include: L. aethiopica, L. arabica, L. donovani, L. enrietti, L. gerbilli, L. hertigi, L. infantum, L. major, L. mexicana, and L. tropica. The following species are those that compose the Leishmania viannia subgenus: L. braziliensis, L. guyanensis, L. lainsoni, L. naiffi, and L. shawi.
Kinetoplastida
Acetylcholinesterase
Tetrahydroisoquinolines
Apomorphine
Emetics
Receptors, Dopamine D2
Morphine
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Plant Poisoning
Biodiversity
Classification
Ontario
A province of Canada lying between the provinces of Manitoba and Quebec. Its capital is Toronto. It takes its name from Lake Ontario which is said to represent the Iroquois oniatariio, beautiful lake. (From Webster's New Geographical Dictionary, 1988, p892 & Room, Brewer's Dictionary of Names, 1992, p391)
Quebec
A province of eastern Canada. Its capital is Quebec. The region belonged to France from 1627 to 1763 when it was lost to the British. The name is from the Algonquian quilibek meaning the place where waters narrow, referring to the gradually narrowing channel of the St. Lawrence or to the narrows of the river at Cape Diamond. (From Webster's New Geographical Dictionary, 1988, p993 & Room, Brewer's Dictionary of Names, 1992, p440)
Plants, Genetically Modified
Psychomotor Agitation
Access to Information
Ancillary Services, Hospital
Bibliometrics
Publishing
Peer Review, Research
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Bronchodilator and anti-inflammatory activities of glaucine: In vitro studies in human airway smooth muscle and polymorphonuclear leukocytes. (1/80)
1. Selective phosphodiesterase 4 (PDE4) inhibitors are of potential interest in the treatment of asthma. We examined the effects of the alkaloid S-(+)-glaucine, a PDE4 inhibitor, on human isolated bronchus and granulocyte function. 2. Glaucine selectively inhibited PDE4 from human bronchus and polymorphonuclear leukocytes (PMN) in a non-competitive manner (Ki=3.4 microM). Glaucine displaced [3H]-rolipram from its high-affinity binding sites in rat brain cortex membranes (IC50 approximately 100 microM). 3. Glaucine inhibited the spontaneous and histamine-induced tone in human isolated bronchus (pD2 approximately 4.5). Glaucine (10 microM) did not potentiate the isoprenaline-induced relaxation but augmented cyclic AMP accumulation by isoprenaline. The glaucine-induced relaxation was resistant to H-89, a protein kinase A inhibitor. Glaucine depressed the contractile responses to Ca2+ (pD'2 approximately 3.62) and reduced the sustained rise of [Ca2+]i produced by histamine in cultured human airway smooth muscle cells (-log IC50 approximately 4.3). 4. Glaucine augmented cyclic AMP levels in human polymorphonuclear leukocytes challenged with N-formyl-Met-Leu-Phe (FMLP) or isoprenaline, and inhibited FMLP-induced superoxide generation, elastase release, leukotriene B4 production, [Ca2+]i signal and platelet aggregation as well as opsonized zymosan-, phorbol myristate acetate-, and A23187-induced superoxide release. The inhibitory effect of glaucine on superoxide generation by FMLP was reduced by H-89. 5. In conclusion, Ca2+ channel antagonism by glaucine appears mainly responsible for the relaxant effect of glaucine in human isolated bronchus while PDE4 inhibition contributes to the inhibitory effects of glaucine in human granulocytes. The very low PDE4/binding site ratio found for glaucine makes this compound attractive for further structure-activity studies. (+info)Mechanical effects of liriodenine on the left ventricular-arterial coupling in Wistar rats: pressure-stroke volume analysis. (2/80)
1. In a recent in vivo study, liriodenine, an aporphine alkaloid, has been identified as a prominent anti-arrhythmic agent that can prevent rats' sudden deaths, even at the dose as low as 10(-7) g kg(-1). The aim of this study was to determine whether liriodenine at its effective anti-arrhythmic dose of 10(-7) g kg(-1) had effects on the left ventricular (LV)-arterial coupling in Wistar rats. 2. LV pressure and ascending aortic flow signals were recorded to construct the ventricular and arterial end-systolic pressure-stroke volume relationships to calculate LV end-systolic elastance (E(es)) and effective arterial volume elastance (E(a)), respectively. The optimal afterload (Q(load)) determined by the ratio of E(a) to E(es) was used to measure the optimality of energy transmission from the left ventricle to the arterial system. 3. Liriodenine at the dose of 10(-7) g kg(-1) showed no significant changes in basal heart rate (HR), cardiac output (CO), LV end-systolic pressure (P(es)), E(a), E(es), and Q(load). 4. By contrast, liriodenine at the dose of 10(-6) g kg(-1) produced a significant fall of 2.0% in HR and a significant rise of 5.8% in CO, but no significant change in P(es). Moreover, liriodenine administration of 10(-6) g kg(-1) to rats significantly decreased E(es) by 8.5% and E(a) by 10.6%, but did not change Q(load). 5. We conclude that liriodenine at the dose of 10(-7) g kg(-1) has no effects on the mechanical properties of the heart and the vasculature and the matching condition for the left ventricle coupled to its vasculature in rats. Even at 10 times the effective anti-arrhythmic dose, liriodenine shows no effects on the efficiency of energy transferred from the left ventricle to the arterial system. (+info)Dicentrine is preferentially antagonistic to rat aortic than splenic alpha 1-adrenoceptor stimulation. (3/80)
AIM: Dicentrine is a known alpha 1-adrenoceptor antagonist, but its alpha 1-adrenoceptor subtype selectivity has not yet been determined. We therefore, investigated the putative alpha 1-adrenoceptor subtype selectivity of this agent. METHODS: Graded isometric contractile responses of rat aortic rings and spleen to phenylephrine were observed in the absence or presence of various concentrations of dicentrine. The pA2 values for dicentrine were determined. RESULTS: Aortic tissues were more sensitive to phenylephrine-induced contraction than the spleen tissues. Dicentrine was approximately 100 times more potent as an antagonist to the aortic contraction, than it was to the splenic contractions. CONCLUSION: Dicentrine is an alpha 1-adrenoceptor antagonist which is more selective towards the putative alpha 1D-adrenoceptor subtype of the rat aorta than the alpha 1B-adrenoceptor of the spleen. (+info)Multiple actions of glaucine on cyclic nucleotide phosphodiesterases, alpha 1-adrenoceptor and benzothiazepine binding site at the calcium channel. (4/80)
1. In the present study, the properties of glaucine (an aporphine structurally related to papaverine) were compared with those of papaverine, diltiazem, nifedipine and prazosin. The work includes functional studies on rat isolated aorta contracted with noradrenaline, caffeine or KCl, and a determination of the affinity of glaucine at calcium channel binding sites of alpha-adrenoceptors, by use of [3H]-(+)-cis-diltiazem, [3H]-nitrendipine and [3H]-prazosin binding to cerebral cortical membranes. The effects of glaucine on the different molecular forms of cyclic nucleotide phosphodiesterases (PDE) isolated from bovine aorta were also determined. 2. Contraction evoked by noradrenaline (1 microM) or depolarizing solution (60 mM KCl) were inhibited in a concentration-dependent manner by all the compounds tested. As expected, prazosin showed a greater selectivity of action on NA-induced contraction, whereas nifedipine and diltiazem appeared more potent on KCl-induced contraction. Glaucine had a greater potency on the contraction elicited by noradrenaline whereas papaverine acted non specifically. 3. In Ca(2+)-free solution, prazosin (0.1 microM) and glaucine (0.1 mM) inhibited the contraction evoked by NA; diltiazem (0.1 mM) diminished this contraction whereas nifedipine (1 microM) had no effect. Preincubation of tissues with glaucine, diltiazem, nifedipine and prazosin did not modify the contractile response induced by caffeine. In contrast, papaverine (0.1 mM) significantly inhibited the contractions evoked by NA or caffeine in Ca(2+)-free medium. 4. Glaucine and papaverine show affinity at the [3H]-prazosin binding site and at the benzothiazepine binding site of the Ca(2+)-channel receptor complex, but have no effect at the dihydropyridine binding site in rat cerebral cortex. Glaucine exerts some selectivity as an inhibitor of [3H]-prazosin binding as opposed to [3H]-(+ )-cis-diltiazem binding while papaverine appears to have approximately equal affinity in this respect.5. This study confirms the presence of four phosphodiesterase (PDE) activities in bovine aorta: a calmodulin-activated PDE (CaM-PDE type I) which hydrolyzed preferentially guanosine 3':5'-cyclic monophosphate (cyclic GMP); a cyclic GMP selective form (cGMP-PDE type V); and two low Km adenosine 3':5'-cyclic monophosphate (cyclic AMP) PDEs that are insensitive to the stimulatory effect of CaM, one of which was inhibited by cyclic GMP (CGI-PDE, type III) and the other by rolipram (cAMP-PDE, type IV). Glaucine selectively inhibits one of the two forms of Ca2+-independent low Km cAMP-PDE, the type IV. In contrast, papaverine exerts a non-selective inhibitory effect upon all PDE forms.6. The present work provides evidence that glaucine, a benzyltetrahydroisoquinoline alkaloid, has interesting properties as an alpha l-adrenoceptor antagonist, calcium entry blocker (through the benzothiazepine recognition site in the calcium channel) and as a selective inhibitor of the rolipram-sensitive cAMP-PDE, type IV PDE. (+info)Haemodynamic effects of dicentrine, a novel alpha 1-adrenoceptor antagonist: comparison with prazosin in spontaneously hypertensive and normotensive Wistar-Kyoto rats. (5/80)
1. The haemodynamic effects of dicentrine, an aporphine derivative isolated from the plant Lindera megaphylla, were investigated and compared with prazosin in rats. 2. In anaesthetized normotensive Wistar-Kyoto (WKY) rats, i.v. administration of dicentrine (0.1, 0.5, 1.0 mg kg-1) and prazosin (0.01, 0.05, 0.1 mg kg-1) induced a dose-related reduction of mean arterial pressure (MAP) which reached a maximal effect 5-10 min after injection and persisted for 2 h. 3. In anaesthetized WKY rats, a higher dose of dicentrine (1.0 mg kg-1, i.v.) did not cause any significant changes in heart rate (HR), cardiac output (CO) and stroke volume (SV) but markedly increased tail blood flow. In contrast, a higher dose of prazosin (0.1 mg kg-1, i.v.) produced a decrease in HR which paralleled the time course of the hypotensive response. 4. The hypotensive activity of dicentrine was completely abolished by alpha-adrenoceptor blockade. Both dicentrine and prazosin significantly attenuated pressor responses to noradrenaline but failed, even at maximal hypotensive doses, to impair the pressor effects of angiotensin II or vasopressin. These observations suggest that dicentrine appears to exert its hypotensive action through alpha 1-adrenoceptor blockade. 5. In conscious normotensive and spontaneously hypertensive (SH) rats, dicentrine (0.5-2.0 mg kg-1, i.v.) and prazosin (0.05-0.2 mg kg-1, i.v.) also evoked dose-related decreases in MAP which were of greater magnitude in SH rats. Oral administration of dicentrine (5 and 8 mg kg-1) to conscious SH rats caused a hypotensive effect which persisted for over 15 h.6. These results suggest that dicentrine may have therapeutic potential as an oral antihypertensive drug via alpha-adrenoceptor blockade. (+info)Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine. (6/80)
Four phenanthrene and one aporphine alkaloids semi-synthesized from boldine were evaluated for their inhibitory effect on reactive oxygen species (ROS) generation. ROS generation by neutrophils stimulated with N-formyl-methionyl-leucyl-phenylalanine was inhibited in a concentration dependent manner. Alkaloids exerted similar inhibitory effect in the hypoxanthine-xanthine oxidase system than in stimulated neutrophils, which could be attributed to a direct ROS scavenging activity. None of the alkaloids assayed had any effect on xanthine oxidase activity. Therefore the synthesized alkaloids might constitute an alternative therapy in inflammation disorders in which ROS generation is involved. (+info)Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. (7/80)
Angiotensin-II (Ang-II) has inflammatory activity and is involved in different diseases associated with the cardiovascular system. This study has evaluated the effect of boldine (B), and two phenanthrene alkaloids semisynthesized by us, secoboldine (SB) and boldine methine (BM), on Ang-II-induced neutrophil recruitment. Intraperitoneal administration of 1 nM Ang-II induced significant neutrophil accumulation, which was maximal at 4-8 h. BM inhibited neutrophil infiltration into the peritoneal cavity at 4 h and 8 h by 73% and 77%, respectively, SB at 8 h by 55%, and B had no effect on this response. Although BM inhibited the release of cytokine-inducible neutrophil chemoattractant/keratinocyte-derived chemokine, macrophage inflammatory protein-2 (MIP-2), and platelet-activating factor (PAF) elicited by Ang-II, SB only reduced the release of MIP-2 after 4 h of its administration. Sixty-minute superfusion of the rat mesentery with 1 nM Ang-II induced a significant increase in the leukocyte-endothelial cell interactions and P-selectin up-regulation, which were inhibited by 1 microM BM and SB. The generation of reactive oxygen species (ROS) in endothelial cells stimulated with Ang-II was inhibited significantly by the three alkaloids tested. BM also diminished Ang-II-induced interleukin-8 release from endothelial cells and blocked the PAF receptor on human neutrophils (concentration of the compound needed to produce 50% inhibition value: 28.2 microM). Therefore, BM is a potent inhibitor of Ang-II-induced neutrophil accumulation in vivo. This effect appears to be mediated through inhibition of CXC chemokine and PAF release, ROS scavenging activity, and blockade of the PAF receptor. Thus, it may have potential therapeutic interest for the control of neutrophil recruitment that occurs in inflammation associated with elevated levels of Ang-II. (+info)Characterization and inhibitor discovery of one novel malonyl-CoA: acyl carrier protein transacylase (MCAT) from Helicobacter pylori. (8/80)
Type II fatty acid synthesis (FAS II) is an essential process for bacteria survival, and malonyl-CoA:acyl carrier protein transacylase (MCAT) is a key enzyme in FAS II pathway, which is responsible for transferring the malonyl group from malonyl-CoA to the holo-ACP by forming malonyl-ACP. In this work, we described the cloning, characterization and enzymatic inhibition of a new MCAT from Helicobacter pylori strain SS1 (HpMCAT), and the gene sequence of HpfabD was deposited in the GenBank database (Accession No. AY738332 ). Enzymatic characterization of HpMCAT showed that the K(m) value for malonyl-CoA was 21.01+/-2.3 microM, and the thermal- and guanidinium hydrochloride-induced unfolding processes for HpMCAT were quantitatively investigated by circular dichroism spectral analyses. Moreover, a natural product, corytuberine, was discovered to demonstrate inhibitory activity against HpMCAT with IC(50) value at 33.1+/-3.29 microM. Further enzymatic assay results indicated that corytuberine inhibits HpMCAT in an uncompetitive manner. To our knowledge, this is the firstly reported MCAT inhibitor to date. This current work is hoped to supply useful information for better understanding the MCAT features of H. pylori strain, and corytuberine might be used as a potential lead compound in the discovery of the antibacterial agents using HpMCAT as target. (+info)
Synthesis of Novel Aporphine-Inspired Neuroreceptor Ligands by Nirav R. Kapadia
Attenuation of post-ischemia reperfusion injury by thaliporphine and morphine in rat hearts. - Semantic Scholar
Boldine - Mr Supplement Australia
The Study of Cytotoxic Effects of Boldine Derivatives on Human Breast Cancer Cells- MCF-7 and MDA-MB231 Cell Lines - ...
Isocorynoline - Biofron
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99% High Quality Lotus Leaf Extract Raw Powder For Weight Loss - Hongkong Yuancheng Gongchuang Technology Co., Limited -...
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Representative images and quantitative analysis of CAOV | Open-i
Potential new inorganic antitumour agents from combining the anticancer traditional Chinese medicine (TCM) liriodenine with...
Lotus leaf flavone nuciferine powder HACCP Kosher FDA factory 20% lotus leaf extract, View lotus leaf extract, World-way...
Antileishmanial and Trypanocidal Activities of Extracts and Aporphine Alkaloids Isolated from Monodora Genus (Annonaceae) |...
Characterization and simultaneous quantification of biological aporphine alkaloids in Litsea cubeba by HPLC with hybrid ion...
Molecules | Free Full-Text | Antioxidant and Anticancer Constituents from the Leaves of Liriodendron tulipifera
bulbocapnine
Summary Report | CureHunter
Nandina domestica Sacred Bamboo, Heavenly Bamboo PFAF Plant Database
Chemical investigation of drug-like compounds from the Australian tree, Neolitsea dealbata | USC Research Bank - University of...
Glaucine - Wikipedia
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Propylnorapomorphine
January 1976). "Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10- ... Miller RJ, Kelly PH, Neumeyer JL (January 1976). "Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in ... N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine. In rodents it has ... and analogous aporphines". Neuropharmacology. 21 (10): 953-61. doi:10.1016/0028-3908(82)90106-X. PMID 6890636. Argiolas A, ...
Annona acuminata
Extracts of bioactive molecules from its tissues have been reported to contain aporphine derivatives. "Annona acuminata Saff". ... Borup-Grochtmann, I.; Kingston, David G. I. (1982). "Aporphine Alkaloids From Annona acuminata". Journal of Natural Products. ...
Cassytha
Stévigny C, Block S, De Pauw-Gillet MC, de Hoffmann E, Llabrès G, Adjakidjé V, Quetin-Leclercq J. Cytotoxic aporphine alkaloids ... I. New aporphine alkaloids fromCassytha filiformisL". Australian Journal of Chemistry. 19 (2): 297. doi:10.1071/CH9660297. ISSN ... "Alkaloids from Cassytha filiformis and related aporphines: antitrypanosomal activity, cytotoxicity, and interaction with DNA ...
Oliveroline
... is an anti-cholinergic aporphine alkaloid. Naaz, H; Singh, S; Pandey, VP; Singh, P; Dwivedi, UN (2013). "Anti- ...
Isoquinoline alkaloids
The most common structural types are the benzylisoquinolines and the aporphines. According to current knowledge, a total of ...
Actinodaphne speciosa
Bandara, BM; Cortes, D; Jayasinghe, UL; Karunaratne, V; Sotheeswaran, S; Wannigama, GP (1989). "Aporphine alkaloids from Litsea ...
Lauraceae
Benzylisoquinoline alkaloids include aporphines and oxoaporphines, as well as derivatives of morphinans. Essential oils include ...
Nymphaea nouchali var. caerulea
Aporphine is said to be main psychoactive compound present. Other compounds include apomorphine and nuciferine. In Southern ... Like other species in the genus, the plant contains the psychoactive alkaloid aporphine (not to be confused with apomorphine). ... Some evidence indicates the effects of plants including N. caerulea that contain the psychoactive alkaloid aporphine were known ...
Hanneke Jansen
Aporphines: Synthesis, Pharmacology, and Modeling of D2Aand 5-HT1AReceptor Interactions". Journal of Medicinal Chemistry. 39 ( ...
Propilnorapomorfin - Википедија
Miller RJ, Kelly PH, Neumeyer JL (1976). „Aporphines. 15. Action of aporphine alkaloids on dopaminergic mechanisms in rat brain ... 1976). „Aporphines. 14 Dopaminergic and antinociceptive activity of aporphine derivatives. Synthesis of 10-hydroxyaporphines ...
Annonamine
Structurally, it contains an aporphine core featuring a quaternary ammonium group. Asimilobine - amine not quaternized Anonaine ... Pukateine Matsushige, A; Kotake, Y; Matsunami, K; Otsuka, H; Ohta, S; Takeda, Y (2012). "Annonamine, a new aporphine alkaloid ...
Hernandaline
α ] D 20 = + 36.5 {\displaystyle [\alpha ]_{D}^{20}=+36.5} ° Aporphine Lakshmi; et al. (2009). "An Overview of Family ...
Nuciferine
Apomorphine Aporphine Glaucine Bulbocapnine Nantenine Pukateine Stepholidine Tetrahydropalmatine Bhattacharya, S. K.; Bose, R ...
Soursop
Matsushige, A; Kotake, Y; Matsunami, K; Otsuka, H; Ohta, S; Takeda, Y (2012). "Annonamine, a new aporphine alkaloid from the ... The leaves of Annona muricata contain annonamine, which is an aporphine-class alkaloid containing a quaternary ammonium group. ...
John Masson Gulland
His main work was on nucleic acids, morphine and aporphine alkaloids. His work at University College Nottingham on ...
Nelumbo nucifera
Both Nymphaea caerulea and Nelumbo nucifera contain the alkaloids nuciferine and aporphine.[citation needed] The genome of the ...
Isooncodine
"Two New Natural Azafluorene Alkaloids and a Cytotoxic Aporphine Alkaloid from Polyalthia longifolia". Journal of Natural ...
Polyfothine
Wu, YC; Duh, CY; Wang, SK; Chen, KS; Yang, TH (1990). "Two new natural azafluorene alkaloids and a cytotoxic aporphine alkaloid ...
Nikola Mollov
Most important were the benzylisoquinoline-aporphine derivatives, a relatively new group of alkaloids. The results obtained ...
Glaucine
... is an aporphine alkaloid found in several different plant species in the family Papaveraceae such as Glaucium flavum, ... Zetler, G. (1988). "Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, ... Zetler G (1988). "Neuroleptic-like, anticonvulsant and antinociceptive effects of aporphine alkaloids: bulbocapnine, ...
Alkaloid
For example, aporphine alkaloid liriodenine produced by the tulip tree protects it from parasitic mushrooms. In addition, the ...
Piperolactam A
It has been suggested that piperolactam A and related compounds are biosynthesised from aporphine precursors. Aristolactams ...
Synthetic cannabinoids
... aporphine, leonurine, nuciferine, and nicotine. Some synthetic cannabinoids products have also been found to contain synthetic ...
Satinder Vir Kessar
Azasteroid Aporphine Heterocyclic compound India portal Chemistry portal His adviser for master's degree was S. M. Mukherji ... Among the other natural products and drugs he synthesized include steroidal sapogenins, phenanthridine, aporphine, quinculidine ... for the synthesis of the phenanthridine ring system and other heterocyclic systems as well as the synthesis of aporphine and ...
Magnoflorine
S)-Magnoflorine is a quaternary benzylisoquinoline alkaloid (BIA) of the aporphine structural subgroup which has been isolated ... "Isolation and Characterization of Reticuline N-Methyltransferase Involved in Biosynthesis of the Aporphine Alkaloid ...
Anonaine
Apomorphine - a related chemical used in the treatment of Parkinson's disease Aporphine - the core alkaloid Nuciferine ...
Boldine
... is an alkaloid of the aporphine class that can be found in the boldo tree and in Lindera aggregata. Boldine has ...
Botanical identity of soma-haoma
In addition, benzoisoquinoline alkaloids found in the Sacred Lotus, including aporphine, proaporphine, and nuciferine, are ...
Canellaceae
... also have alkaloids of the aporphine type, such as N-(cinnamoil)-tryptamine, lignans of the aryl-tetralin type, ...
Aporphine - Wikipedia
Aporphine is an alkaloid with the chemical formula C 17H 17N. It is the core chemical substructure of the aporphine alkaloids, ... It can exist in either of two enantiomeric forms, (R)-aporphine and (S)-aporphine. Many different derivatives have been ... R)-Aporphine is a dopamine receptor D1 antagonist with a Ki of 717 nM and a dopamine receptor D2 antagonist with a Ki of 527 nM ... Some derivatives of aporphine such as (S)-(+)-N-propylnorapomorphine have potential as low side effect profile antipsychotics ...
Aporphine alkaloids - Wikipedia
The aporphine alkaloids are of interest mainly because of their similarity to morphine. The aporphine alkaloids are most ... At least 85 aporphine alkaloids have been isolated from plants of 15 families. The best known representative is apomorphine. ... The aporphine alkaloids usually have a stereocenter. The (R)-configured glaucine can be synthesized from (S)-glaucine. ... Aporphine alkaloids are naturally occurring chemical compounds from the group of alkaloids. After the benzylisoquinoline ...
Liriodenine, an aporphine alkaloid from -Enico-santhellum pulc | DDDT
... an aporphine alkaloid from -Enico-santhellum pulchrum, inhibits proliferation of human ovarian cancer cells through induction ... Liriodenine, an aporphine alkaloid from -Enico-santhellum pulchrum, inhibits proliferation of human ovarian cancer cells ... Mutagenicity of isoquinoline alkaloids, especially of the aporphine type. Mutat Res. 1990;240:267-279. ... Electrophysiological mechanisms for antiarrhythmic efficacy and positive inotropy of liriodenine, a natural aporphine alkaloid ...
Aporphine and tetrahydroprotoberberine alkaloids from the leaves of Guatteria friesiana (Annonaceae) and their cytotoxic...
Aporphine and tetrahydroprotoberberine alkaloids from the leaves of Guatteria friesiana (Annonaceae) and their cytotoxic ... The presence of aporphine and tetrahydroprotoberberine alkaloids in the leaves of G. friesiana is consistent with previous ... Aporphine and tetrahydroprotoberberine alkaloids isolated from the leaves of Guatteria friesiana (Annonaceae). ... 13 as well as aporphine alkaloids.8 The alkaloids and essential oils exhibited antitumor and antimicrobial properties,4,6-9 as ...
Characterization and simultaneous quantification of biological aporphine alkaloids in Litsea cubeba by HPLC with hybrid ion...
Aporphine alkaloids are its characteristic ingredients and responsible for its bioactivities, especially anti-inflammatory and ... The fragmentation pathways by loss of CO, ·CH3 , ·NH3 , and ·NH2 CH3 were detected as characteristic for aporphine alkaloids. ... The established method is simple, rapid, and specific for characterization and quantitation of aporphine alkaloids in Dou-chi- ... The quantification method was validated in terms of linearity, precision, and accuracy for six major aporphine alkaloids, which ...
Antileishmanial and Trypanocidal Activities of Extracts and Aporphine Alkaloids Isolated from Monodora Genus (Annonaceae) |...
The organic solvent extracts of M. crispat, M. brevipes and their isolated aporphines showed varied levels of activity against ... The oxoaporphines were generally the most active especially against L. donovani (14.59 ≤ IC50 ≥ 52.20 μm). The aporphine, (+)- ... Eleven aporphines alkaloids (Figure 1) identified as, (-)- mocrispatine (1); (-)-pallidine (2); (-) N-méthylarmépavine (3 ... The generally low antiprotozoal activity of the aporphines does not make them good candidates for either leishmaniasis or ...
Cytotoxic aporphine alkaloids from Cassytha filiformis. - Stevigny C.
Purification of Cinnamic Acid and Aporphine Alkaloids from Enicosanthellum pulchrum Twig Extract and their Biological...
Omar, H.; Hashim, N.M.; Zajmi, A.; Nordin, N.; Abdelwahab, S.I.; Azizan, A.H.S.; Hadi, A.H.A.; Ali, H.M. Aporphine alkaloids ... Results: Cinnamic acid (1) and two aporphine alkaloids (liridine (2) and lysicamine (3)) have been successfully purified and ... Title:Purification of Cinnamic Acid and Aporphine Alkaloids from Enicosanthellum pulchrum Twig Extract and their Biological ... Results: Cinnamic acid (1) and two aporphine alkaloids (liridine (2) and lysicamine (3)) have been successfully purified and ...
"Synthesis of Novel Aporphine-Inspired Neuroreceptor Ligands" by Nirav R. Kapadia
The aporphine template is known to be associated with a range of biological activities. Aporphines have been explored as ... Aporphines are also inhibitors of the acetylcholinesterase enzyme - a clinical target for the treatment of Alzheimers disease ... Within the Central Nervous Systems (CNS), aporphine alkaloids are known to possess high affinity for several clinically ... Considering the diverse profile of aporphine alkaloids at CNS receptors they can be considered as ...
Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity | Bol. latinoam. Caribe plantas med....
Aporphine alkaloids from Piper erecticaule and acetylcholinesterase inhibitory activity Aporphine alkaloids from Piper ... Full text: Available Index: LILACS (Americas) Main subject: Aporphines / Acetylcholinesterase / Plant Extracts / Cholinesterase ... Aporphines/pharmacology , Acetylcholinesterase/drug effects , Plant Extracts/chemistry , Cholinesterase Inhibitors/pharmacology ... Piper/chemistry , Alkaloids/pharmacology , Aporphines/chemistry , Terpenes/isolation & purification , Cholinesterase Inhibitors ...
ChemIDplus - 28277-71-6 - RZERUPREKNWRRD-UHFFFAOYSA-N - Aporphine, 1,2,10-trimethoxy-, dl- - Similar structures search,...
The Isoquinoline Alkaloids Chemistry and Pharmacology - 1st Edition
The Aporphines. I. Introduction II. A Classical Degradation of an Aporphine III. Apomorphine IV. Nonbiogenetic Syntheses of ... Ushinsunine: A C-7 Hydroxylated Aporphine XV. Steporphine: A C-4 Hydroxylated Aporphine XVI. The Dehydroaporphines References ... The Oxidation of Aporphines and the Reduction of Oxoaporphines. IV. An Unusual Demethoxylation Reaction V. Pharmacology VI. NMR ... The Aporphine-Benzylisoquinoline Dimers. I. Introduction II. Structural Elucidation and Synthesis III. Biosynthesis IV. ...
Abstract of Apoptotic Activity of Aporphine from Stephania venosa on Human Ovarian Cancer Cells
Structure of the pure constituent was determined by NMR technique and identified as aporphine. Aporphine from S. venosa showed ... Apoptotic Activity of Aporphine from Stephania venosa on Human Ovarian Cancer Cells. K. Montririttigri, P. Moongkarndi,* S. ... alkaloids, apoptosis, aporphine, cancer, caspase, DNA fragmentation, MTT assay, NMR, Stephania venosa, Ovarian Cancer Download ... Apoptotic Activity of Aporphine from Stephania venosa on Human Ovarian Cancer Cells ...
Aporphine | Open Access articles | Open Access journals | Conference Proceedings | Editors | Authors | Reviewers | scientific...
Aporphine. Aporphine Chemical structure of aporphine colspan=2 style="background:#f8eaba; border-top:2px solid transparent; ... Aporphine is a 5-HT1a partial agonist with a ki of 80nM and a 5-HT7 antagonist with a ki of 88nM.[2] Aporphine is a Dopamine D1 ... Aporphine is one of a class of quinoline alkaloids. Many different relatives of this compound have been purified from plants.[1 ... This page is based on the copyrighted Wikipedia article Aporphine; it is used under the Creative Commons Attribution-ShareAlike ...
Alkaloids from Cassytha filiformis and related aporphines : antitrypanosomal activity, cytotoxicity and interaction with DNA...
Alkaloids from Cassytha filiformis and related aporphines : antitrypanosomal activity, cytotoxicity and interaction with DNA ... Home» Alkaloids from Cassytha filiformis and related aporphines : antitrypanosomal activity, cytotoxicity and interaction with ... Alkaloids from Cassytha filiformis and related aporphines : antitrypanosomal activity, cytotoxicity and interaction with DNA ...
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Topics: Medicinal chemistry; Natural products; Photochemistry reactivity; Aporphines, oxoaporphines, and oxoisoaporphines; ... Topics: Medicinal chemistry; Natural products; Photochemistry reactivity; Aporphines, oxoaporphines, and oxoisoaporphines; ... Topics: Medicinal chemistry; Natural products; Photochemistry reactivity; Aporphines, oxoaporphines, and oxoisoaporphines; ...
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Laurales
S)-Isocorydine
Apomorphine - DrugBank
Aporphines. Sub Class. Not Available. Direct Parent. Aporphines. Alternative Parents. Phenanthrenes and derivatives / ... Aporphine / Benzoquinoline / Phenanthrene / 2-naphthol / 1-naphthol / Naphthalene / Quinoline / Tetrahydroisoquinoline / 1- ... This compound belongs to the class of organic compounds known as aporphines. These are quinoline alkaloids containing the ...
Alan Brent Packard, Ph.D. | Harvard Catalyst Profiles | Harvard Catalyst
Canadian Poisonous Plants Information System - Dicentra canadensis (Scientific name) - Canadian Biodiversity Information...
Boldine (CHEBI:3148)
Mechanism of Selective Inhibition of Yohimbine and Its Derivatives in Adrenoceptor α2 Subtypes
BoldineIsoquinoline alkaloidsApomorphineAlkaloids isolatedCytotoxicAlkaloid isolatedProtoberberineCompoundsAnaloguesDopamine agonistAntinociceptiveMorphineActinodaphnineNantenineBenzylisoquinoline1976MorphinanAcetylcholinesteraseBiological ActivitiesFlavonoidsFiliformisDerivativesBenzyltetrahydroisoquinolinesCharacteristicSpeciesAnticancerSubstituentsLeavesNaturallyChemicalAntagonistCommonlySuccessfullyIsolated from plantsCellsActivitiesRing structureGroup
Boldine4
- Aporphine and its related alkaloids bulbocapnine, boldine, glaucine, and corytuberine are antipsychotic, exert naloxone-reversible antinociceptive activity, and with the exception of corytuberine are anticonvulsant. (wikipedia.org)
- Study of butanol extract of leaves and twigs yielded two new aporphine alkaloids, namely litseglutine A and B, along with two known aporphine alkaloids, boldine and laurolitsine. (stuartxchange.org)
- Isoquinoleinic alkaloids (0.2-0.5%): Boldo contains about 20 alkaloids derived from aporphine, the most important being boldine, which represents 25-30% of the total alkaloids. (botanical-online.com)
- It contains 0.2% aporphine alkaloids with boldine as its main compound, as well as flavonols and their glycosides (boldoglucin and isorhamnetin). (ageless.co.za)
Isoquinoline alkaloids2
- Aporphine and protopine, which are isoquinoline alkaloids, have been found in Dicentra species. (gc.ca)
- Genus Phoebe have been reported to produce isoquinoline alkaloids as aporphines, noraporphines, and benzylisoquinolines. (phcogj.com)
Apomorphine3
- Aporphine is hydroxylated in the body to form apomorphine. (wikipedia.org)
- Apoglaziovine Apomorphine Bulbocapnine Corydine Glaucine Isoboldine Isothebaine Nuciferine The aporphine alkaloids differ in their substituents and their position on the base structure. (wikipedia.org)
- [ 1 ] One commonly used aporphine derivative is apomorphine , although it does not occur naturally. (omicsgroup.org)
Alkaloids isolated1
- In the search for agents from tropical medicinal plants to treat these two neglected tropical diseases, serially extracted petroleum ether, dichloromethane and methanol extracts of the leaves of Monodora crispata and Monodora brevipes , and eleven aporphines alkaloids isolated from the dried powdered leaves of the two plants were evaluated against Leishmania donovani promastigotes and Trypanosoma brucei brucei trypomastigotes. (omicsonline.org)
Cytotoxic4
- Cytotoxic aporphine alkaloids from Cassytha filiformis. (uliege.be)
- en] Purification of a cytotoxic crude alkaloid extract of Cassytha filiformis led to the isolation of four known aporphine alkaloids: neolitsine, dicentrine, cassythine (= cassyfiline) and actinodaphnine. (uliege.be)
- This supports the idea that aporphine alkaloids are responsible for the plant's cytotoxic activity. (naturalnews.com)
- Two new natural azaflu-orene alkaloids and a cytotoxic aporphine alkaloid from Poiyaithia longifolia . (springer.com)
Alkaloid isolated2
- Cerasoidine, a bis-aporphine alkaloid isolated from Poiyaithia cerasoides during screening for Wnt signal inhibitors. (springer.com)
- Asimilobine is an aporphine isoquinoline alkaloid isolated from plant species of Magnolia obobata Thun. (medchemexpress.com)
Protoberberine2
- The chromatographic conditions were optimized on a SinoChrom ODS-BP column to obtain a good separation of the four types of alkaloid analytes, including two aporphines (isocorydine, corydine), two protopines (protopine and allocryptopine), a morphine (sinoacutine), and three quaternary protoberberine alkaloids (berberrubine, 5-hydroxycoptisine, and berberine). (jove.com)
- Anti-protozoal activity of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. (ac.ke)
Compounds5
- Aporphine alkaloids are naturally occurring chemical compounds from the group of alkaloids. (wikipedia.org)
- These compounds will further expand our understanding of the tolerance of the aporphine core required for 5-HT 2A antagonism. (cuny.edu)
- Accordingly, there is a need in the art for new methods in addition to the linear skin incision model in rats which allow direct observations and measurements of wound-healing acceleration in taspine and taspinates and their aporphine-derived analogs and other aporphine-derived compounds. (google.com)
- They were able to identify four major compounds, which were the aporphine alkaloids actinodaphnine, anonaine, isoboldine, and nornuciferine. (naturalnews.com)
- The biosynthesis of these compounds has been of considerable interest due in large part to the inclusion of both an aryl carboxylic acid and an aryl nitro functionality (uncommon in natural products) within their structures, which suggested an apparent biogenetic relationship to the well-known aporphine alkaloids. (wikipedia.org)
Analogues3
- In order to understand the structural tolerance of the aporphine core required for 5-HT 2A antagonism an exhaustive Structure Activity Relationship (SAR) study was designed.Accordingly, a diverse library of nantenine analogues was synthesized and evaluated for affinity at the 5-HT 2A receptor. (cuny.edu)
- Based on results of these studies, it is concluded that the interaction of C3 halogenated aporphine analogues with Phe339/Phe340 residues might be responsible for their enhanced affinity. (cuny.edu)
- These are analogues of Aporphines, where a nitrogen atom replaces the carbon atom at position 1, and a keto group at C7. (hmdb.ca)
Dopamine agonist1
- Comparative assessment of dopamine agonist aporphines as anticonvulsants in two models of reflex epilepsy. (axonmedchem.com)
Antinociceptive1
- 14 Dopaminergic and antinociceptive activity of aporphine derivatives. (wikipedia.org)
Morphine3
- The aporphine alkaloids are of interest mainly because of their similarity to morphine. (wikipedia.org)
- The aporphine alkaloids are of particular interest because of their proximity to morphine and benzylisoquinoline alkaloids. (wikipedia.org)
- From Croton chilensis, a monotypic species, morphine and aporphine alkaloids were obtained. (scielo.cl)
Actinodaphnine1
- In vitro tests of some aporphine derivatives isolated from Cassytha filiformis, namely actinodaphnine, cassythine, and dicentrine, showed antiparasitic activity against Trypanosoma brucei. (wikipedia.org)
Nantenine2
Benzylisoquinoline1
- Biochemically, magnoliids are characterized by the presence of benzylisoquinoline or aporphine alkaloids , which are secondary metabolites with a defensive function and are rare in other groups. (britannica.com)
19762
- 1976). „Aporphines. (wikipedia.org)
- Cotzias GC, Papavasiliou PS, Tolosa ES, Mendez JS, Bell-Midura M (1976) Treatment of Parkinson's disease with aporphines. (springer.com)
Morphinan1
- Phylogenetic analysis was performed for each of 15 different enzyme/protein groupings, highlighting many novel genes with potential involvement in the formation of one or more alkaloid types, including morphinan, aporphine, and phthalideisoquinoline alkaloids. (beds.ac.uk)
Acetylcholinesterase1
- Aporphines are also inhibitors of the acetylcholinesterase enzyme - a clinical target for the treatment of Alzheimer's disease. (cuny.edu)
Biological Activities1
- The aporphine template is known to be associated with a range of biological activities. (cuny.edu)
Flavonoids1
- The relative concentration of alkaloids and phenolics in boldo leaves and their activity suggest that free-radical scavenging effect is mainly due to catechin and flavonoids and that antioxidant effect is mainly related with the catechin content The high catechin content of boldo leaves and its bioactivity suggest that quality control of Boldo folium has to combine the analysis of catechin as well as their characteristic aporphine alkaloids. (worldwidescience.org)
Filiformis1
- Cassytha filiformis, a plant used in African traditional medicine, contains many aporphine alkaloids and that the three main alkaloids actinodaphnin, cassythin, and dicentrin have an in vitro effect on cancer cells. (wikipedia.org)
Derivatives1
- Some derivatives of aporphine such as (S)-(+)-N-propylnorapomorphine have potential as low side effect profile antipsychotics. (wikipedia.org)
Benzyltetrahydroisoquinolines1
- In spite of this fairly broad variety of benzyltetrahydroisoquinolines and aporphines, the concentrations of these alkaloids in the different organs of C. alba are quite low, which is in contrast with the sometimes generous yields of alkaloids in this genus. (conicyt.cl)
Characteristic3
- Aporphine alkaloids are its characteristic ingredients and responsible for its bioactivities, especially anti-inflammatory and analgesic effects. (sigmaaldrich.com)
- The fragmentation pathways by loss of CO, ·CH3 , ·NH3 , and ·NH2 CH3 were detected as characteristic for aporphine alkaloids. (sigmaaldrich.com)
- The high catechin content of boldo leaves and its bioactivity suggest that quality control of boldo folium has to combine the analysis of catechin as well as their characteristic aporphine alkaloids. (sigmaaldrich.com)
Species1
- For example, many water-lilies (Nymphaea species) produce aporphine alkaloids such as nymphaeine, nymphaline, nupharine, α- and β-nupharidine. (wikipedia.org)
Anticancer1
- Aporphines have been explored as antioxidants, anti-tuberculosis, antimicrobial and anticancer agents. (cuny.edu)
Substituents1
- Finally, a novel series of flexible tris-(phenylalkyl)amines were synthesized and evaluated to test the importance of a rigid aporphine core as well as incorporation of N-phenylalkyl substituents. (cuny.edu)
Leaves3
- Norstephalagine ( 2 ) (an aporphine) and scopoletin ( 8 ) (a coumarin) were isolated from Liriodendron tulipifera leaves from the first time. (mdpi.com)
- Aporphine Alkaloids from the Leaves of Phoebe grandis (Nees) Mer. (mdpi.com)
- 8 The composition and antimicrobial effect of the essential oil distilled from the very aromatic leaves has also been investigated by at least three independent groups, and is composed mainly of monoterpenoids such as terpin-1-en-4-ol, β-terpinene, 1,8-cineole (eucalyptol), p-cymene, α - and β-pinene. (conicyt.cl)
Naturally1
- together with seven known sesquiterpenes including a new naturally-occurring lindenanolide H (4) and eight known aporphine alkaloids. (go.jp)
Chemical2
- Aporphine is an alkaloid with the chemical formula C 17H 17N. (wikipedia.org)
- It is the core chemical substructure of the aporphine alkaloids, a subclass of quinoline alkaloids. (wikipedia.org)
Antagonist3
- R)-Aporphine is a dopamine receptor D1 antagonist with a Ki of 717 nM and a dopamine receptor D2 antagonist with a Ki of 527 nM. (wikipedia.org)
- Aporphine is a 5-HT1a partial agonist with a ki of 80nM and a 5-HT7 antagonist with a ki of 88nM. (omicsgroup.org)
- [ 2 ] Aporphine is a Dopamine D1 antagonist with a ki of 717nM [ 3 ] and a dopamine D2 antagonist with a ki of 527nM. (omicsgroup.org)
Commonly1
- The aporphine alkaloids are most commonly found in plants. (wikipedia.org)
Successfully2
- The quantification method was validated in terms of linearity, precision, and accuracy for six major aporphine alkaloids, which was successfully applied for simultaneous determination in ten batches of samples. (sigmaaldrich.com)
- Results: Cinnamic acid (1) and two aporphine alkaloids (liridine (2) and lysicamine (3)) have been successfully purified and identified. (eurekaselect.com)
Isolated from plants1
- At least 85 aporphine alkaloids have been isolated from plants of 15 families. (wikipedia.org)
Cells2
- Results from the morphological changes, DNA fragmentation and caspase activation assay, in this study demonstrated that aporphine could significantly inhibit the treated tumor cell proliferation and cause cells death via apoptosis, whereas those were not found in the untreated cells. (mahidol.ac.th)
- BBB-permeable aporphine-type alkaloids in Nelumbo nucifera flowers with accelerative effects on neurite outgrowth in PC-12 cells. (nih.gov)
Activities1
- Scientists attribute the family's wide range of pharmacological activities to acetogenins and isoquinolines, specifically aporphine alkaloids . (naturalnews.com)
Ring structure1
- The method by which the central aporphine ring structure is constructed in nature is exemplified by the biosynthesis of bulbocarpin. (wikipedia.org)
Group1
- Aporphines are a group of tetracyclic alkaloids that belong to the ubiquitous tetrahydroisoquinoline family. (cuny.edu)