Proto-Oncogene Proteins c-bcl-2
Membrane proteins encoded by the BCL-2 GENES and serving as potent inhibitors of cell death by APOPTOSIS. The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma.
bcl-2-Associated X Protein
Apoptosis
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Apoptosis Regulatory Proteins
Iron Regulatory Protein 1
A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. Its RNA binding ability and its aconitate hydrolase activity are dependent upon availability of IRON.
Caspases
A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.
Iron Regulatory Protein 2
Caspase 3
Inhibitor of Apoptosis Proteins
A conserved class of proteins that control APOPTOSIS in both VERTEBRATES and INVERTEBRATES. IAP proteins interact with and inhibit CASPASES, and they function as ANTI-APOPTOTIC PROTEINS. The protein class is defined by an approximately 80-amino acid motif called the baculoviral inhibitor of apoptosis repeat.
DNA Fragmentation
Leucine-Responsive Regulatory Protein
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
In Situ Nick-End Labeling
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.
Signal Transduction
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
X-Linked Inhibitor of Apoptosis Protein
Cell Survival
Cells, Cultured
Apoptosis Inducing Factor
A flavoprotein that functions as a powerful antioxidant in the MITOCHONDRIA and promotes APOPTOSIS when released from the mitochondria. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein family. It translocates to the CELL NUCLEUS and binds DNA to stimulate CASPASE-independent CHROMATIN condensation.
Iron-Regulatory Proteins
CASP8 and FADD-Like Apoptosis Regulating Protein
An APOPTOSIS-regulating protein that is structurally related to CASPASE 8 and competes with CASPASE 8 for binding to FAS ASSOCIATED DEATH DOMAIN PROTEIN. Two forms of CASP8 and FADD-like apoptosis regulating protein exist, a long form containing a caspase-like enzymatically inactive domain and a short form which lacks the caspase-like domain.
Enzyme Activation
Mitochondria
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Tumor Cells, Cultured
Caspase 9
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Caspase 9 is activated during cell stress by mitochondria-derived proapoptotic factors and by CARD SIGNALING ADAPTOR PROTEINS such as APOPTOTIC PROTEASE-ACTIVATING FACTOR 1. It activates APOPTOSIS by cleaving and activating EFFECTOR CASPASES.
Caspase Inhibitors
Tumor Suppressor Protein p53
Transcription Factors
Base Sequence
Blotting, Western
Amino Acid Sequence
DNA-Binding Proteins
Caspase 8
A long pro-domain caspase that contains a death effector domain in its pro-domain region. Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS.
Cell Cycle
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Fas Ligand Protein
A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. It plays an important role in immune homeostasis and cell-mediated toxicity by binding to the FAS RECEPTOR and triggering APOPTOSIS.
Protein Binding
Transfection
bcl-X Protein
Cytochromes c
Transcription, Genetic
Phosphorylation
Proto-Oncogene Proteins
Gene Expression Regulation
Carrier Proteins
Flow Cytometry
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Mutation
Gene Expression Regulation, Bacterial
Cysteine Proteinase Inhibitors
Annexin A5
Enzyme Inhibitors
Amino Acid Chloromethyl Ketones
Antigens, CD55
Cell Division
RNA, Small Interfering
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Down-Regulation
Promoter Regions, Genetic
Poly(ADP-ribose) Polymerases
Binding Sites
Jurkat Cells
HeLa Cells
Membrane Proteins
Reactive Oxygen Species
Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.
Dose-Response Relationship, Drug
Repressor Proteins
Reverse Transcriptase Polymerase Chain Reaction
HL-60 Cells
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
Up-Regulation
TNF-Related Apoptosis-Inducing Ligand
A transmembrane-protein belonging to the TNF family of intercellular signaling proteins. It is a widely expressed ligand that activates APOPTOSIS by binding to TNF-RELATED APOPTOSIS-INDUCING LIGAND RECEPTORS. The membrane-bound form of the protein can be cleaved by specific CYSTEINE ENDOPEPTIDASES to form a soluble ligand form.
GTP-Binding Proteins
Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.
Antigens, CD59
Cell Death
Tumor Necrosis Factor-alpha
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Nuclear Proteins
Cell Nucleus
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Recombinant Fusion Proteins
Cell Cycle Proteins
Proteins that control the CELL DIVISION CYCLE. This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS.
Gene Expression
Immediate-Early Proteins
Proteins that are coded by immediate-early genes, in the absence of de novo protein synthesis. The term was originally used exclusively for viral regulatory proteins that were synthesized just after viral integration into the host cell. It is also used to describe cellular proteins which are synthesized immediately after the resting cell is stimulated by extracellular signals.
Models, Biological
Trans-Activators
NF-kappa B
Caspase 7
Protein-Serine-Threonine Kinases
Membrane Potential, Mitochondrial
Immunohistochemistry
Proteins
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Glucokinase
Mice, Knockout
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
Genes, bcl-2
DNA Damage
Injuries to DNA that introduce deviations from its normal, intact structure and which may, if left unrepaired, result in a MUTATION or a block of DNA REPLICATION. These deviations may be caused by physical or chemical agents and occur by natural or unnatural, introduced circumstances. They include the introduction of illegitimate bases during replication or by deamination or other modification of bases; the loss of a base from the DNA backbone leaving an abasic site; single-strand breaks; double strand breaks; and intrastrand (PYRIMIDINE DIMERS) or interstrand crosslinking. Damage can often be repaired (DNA REPAIR). If the damage is extensive, it can induce APOPTOSIS.
Cytochrome c Group
Proto-Oncogene Proteins c-akt
Protein Structure, Tertiary
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Gene Expression Regulation, Neoplastic
Genes, Regulator
bcl-2 Homologous Antagonist-Killer Protein
Neoplasm Proteins
Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.
Necrosis
The pathological process occurring in cells that are dying from irreparable injuries. It is caused by the progressive, uncontrolled action of degradative ENZYMES, leading to MITOCHONDRIAL SWELLING, nuclear flocculation, and cell lysis. It is distinct it from APOPTOSIS, which is a normal, regulated cellular process.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Immunoblotting
RNA-Binding Proteins
RNA Interference
A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
Oxidative Stress
Cloning, Molecular
Staurosporine
Myeloid Cell Leukemia Sequence 1 Protein
A member of the myeloid leukemia factor (MLF) protein family with multiple alternatively spliced transcript variants encoding different protein isoforms. In hematopoietic cells, it is located mainly in the nucleus, and in non-hematopoietic cells, primarily in the cytoplasm with a punctate nuclear localization. MLF1 plays a role in cell cycle differentiation.
Cysteine Endopeptidases
Antigens, CD46
BH3 Interacting Domain Death Agonist Protein
PII Nitrogen Regulatory Proteins
Sequence Homology, Amino Acid
Intracellular Signaling Peptides and Proteins
Proteins and peptides that are involved in SIGNAL TRANSDUCTION within the cell. Included here are peptides and proteins that regulate the activity of TRANSCRIPTION FACTORS and cellular processes in response to signals from CELL SURFACE RECEPTORS. Intracellular signaling peptide and proteins may be part of an enzymatic signaling cascade or act through binding to and modifying the action of other signaling factors.
Rats, Sprague-Dawley
Plasmids
DNA Primers
Cyclin-Dependent Kinase Inhibitor p21
Operon
Fibroblasts
Aconitate Hydratase
Epithelial Cells
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Antigens, CD47
bcl-Associated Death Protein
Tumor Suppressor Proteins
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Mitogen-Activated Protein Kinases
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
Cell Differentiation
Iron
Antineoplastic Agents, Phytogenic
Ceramides
Receptors, TNF-Related Apoptosis-Inducing Ligand
Tumor necrosis factor receptor family members that are widely expressed and play a role in regulation of peripheral immune responses and APOPTOSIS. The receptors are specific for TNF-RELATED APOPTOSIS-INDUCING LIGAND and signal via conserved death domains that associate with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Transcriptional Activation
Caspase 2
A long pro-domain caspase that contains a caspase recruitment domain in its pro-domain region. Activation of this enzyme can occur via the interaction of its caspase recruitment domain with CARD SIGNALING ADAPTOR PROTEINS. Caspase 2 plays a role in APOPTOSIS by cleaving and activating effector pro-caspases. Several isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.
Mice, Transgenic
Cyclins
Protein Transport
Hydrogen Peroxide
Fas-Associated Death Domain Protein
A signal-transducing adaptor protein that associates with TNF RECEPTOR complexes. It contains a death effector domain that can interact with death effector domains found on INITIATOR CASPASES such as CASPASE 8 and CASPASE 10. Activation of CASPASES via interaction with this protein plays a role in the signaling cascade that leads to APOPTOSIS.
Adaptor Proteins, Signal Transducing
A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes
U937 Cells
Microscopy, Fluorescence
Cycloheximide
Cholesterol Side-Chain Cleavage Enzyme
A mitochondrial cytochrome P450 enzyme that catalyzes the side-chain cleavage of C27 cholesterol to C21 pregnenolone in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. This enzyme, encoded by CYP11A1 gene, catalyzes the breakage between C20 and C22 which is the initial and rate-limiting step in the biosynthesis of various gonadal and adrenal steroid hormones.
Proteasome Endopeptidase Complex
A large multisubunit complex that plays an important role in the degradation of most of the cytosolic and nuclear proteins in eukaryotic cells. It contains a 700-kDa catalytic sub-complex and two 700-kDa regulatory sub-complexes. The complex digests ubiquitinated proteins and protein activated via ornithine decarboxylase antizyme.
Mice, Nude
Apoptotic Protease-Activating Factor 1
Calcium
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
Complement Inactivator Proteins
Serum proteins that negatively regulate the cascade process of COMPLEMENT ACTIVATION. Uncontrolled complement activation and resulting cell lysis is potentially dangerous for the host. The complement system is tightly regulated by inactivators that accelerate the decay of intermediates and certain cell surface receptors.
p38 Mitogen-Activated Protein Kinases
A mitogen-activated protein kinase subfamily that regulates a variety of cellular processes including CELL GROWTH PROCESSES; CELL DIFFERENTIATION; APOPTOSIS; and cellular responses to INFLAMMATION. The P38 MAP kinases are regulated by CYTOKINE RECEPTORS and can be activated in response to bacterial pathogens.
Cell Membrane
Cell Line, Transformed
Gene Expression Regulation, Viral
Microtubule-Associated Proteins
Liver
Phosphatidylinositol 3-Kinases
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
Iron-Sulfur Proteins
Drug Resistance, Neoplasm
Receptors, Tumor Necrosis Factor
T-Lymphocytes
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
Cattle
Virulence Factors, Bordetella
A set of BACTERIAL ADHESINS and TOXINS, BIOLOGICAL produced by BORDETELLA organisms that determine the pathogenesis of BORDETELLA INFECTIONS, such as WHOOPING COUGH. They include filamentous hemagglutinin; FIMBRIAE PROTEINS; pertactin; PERTUSSIS TOXIN; ADENYLATE CYCLASE TOXIN; dermonecrotic toxin; tracheal cytotoxin; Bordetella LIPOPOLYSACCHARIDES; and tracheal colonization factor.
Caspase 1
A long pro-domain caspase that has specificity for the precursor form of INTERLEUKIN-1BETA. It plays a role in INFLAMMATION by catalytically converting the inactive forms of CYTOKINES such as interleukin-1beta to their active, secreted form. Caspase 1 is referred as interleukin-1beta converting enzyme and is frequently abbreviated ICE.
Adenosine Diphosphate Ribose
Disease Models, Animal
Gene Deletion
G1 Phase
Cytoplasm
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Pertussis Toxin
Phenotype
Gene Expression Profiling
Adenylate Cyclase
Culture Media, Serum-Free
Cercopithecus aethiops
Neurons
Guanosine 5'-O-(3-Thiotriphosphate)
Guanosine 5'-(trihydrogen diphosphate), monoanhydride with phosphorothioic acid. A stable GTP analog which enjoys a variety of physiological actions such as stimulation of guanine nucleotide-binding proteins, phosphoinositide hydrolysis, cyclic AMP accumulation, and activation of specific proto-oncogenes.
Cytosol
Immunoprecipitation
Rats, Wistar
Electrophoretic Mobility Shift Assay
An electrophoretic technique for assaying the binding of one compound to another. Typically one compound is labeled to follow its mobility during electrophoresis. If the labeled compound is bound by the other compound, then the mobility of the labeled compound through the electrophoretic medium will be retarded.
Gene Knockdown Techniques
Viral Regulatory and Accessory Proteins
A broad category of viral proteins that play indirect roles in the biological processes and activities of viruses. Included here are proteins that either regulate the expression of viral genes or are involved in modifying host cell functions. Many of the proteins in this category serve multiple functions.
Protein Isoforms
Ubiquitin-Protein Ligases
A diverse class of enzymes that interact with UBIQUITIN-CONJUGATING ENZYMES and ubiquitination-specific protein substrates. Each member of this enzyme group has its own distinct specificity for a substrate and ubiquitin-conjugating enzyme. Ubiquitin-protein ligases exist as both monomeric proteins multiprotein complexes.
Etoposide
A semisynthetic derivative of PODOPHYLLOTOXIN that exhibits antitumor activity. Etoposide inhibits DNA synthesis by forming a complex with topoisomerase II and DNA. This complex induces breaks in double stranded DNA and prevents repair by topoisomerase II binding. Accumulated breaks in DNA prevent entry into the mitotic phase of cell division, and lead to cell death. Etoposide acts primarily in the G2 and S phases of the cell cycle.
Decreased expression of the pro-apoptotic protein Par-4 in renal cell carcinoma. (1/5488)
Par-4 is a widely expressed leucine zipper protein that confers sensitization to apoptosis induced by exogenous insults. Because the expression of genes that promote apoptosis may be down-regulated during tumorigenesis, we sought to examine the expression of Par-4 in human tumors. We present here evidence that Par-4 protein levels were severely decreased in human renal cell carcinoma specimens relative to normal tubular cells. Replenishment of Par-4 protein levels in renal cell carcinoma cell lines conferred sensitivity to apoptosis. Because apoptosis may serve as a defense mechanism against malignant transformation or progression, decreased expression of Par-4 may contribute to the pathophysiology of renal cell carcinoma. (+info)Characterization of a novel mouse cDNA, ES18, involved in apoptotic cell death of T-cells. (2/5488)
Using the modified screening approach in combination with expressed sequence tags, we have identified several novel cDNAs from mouse embryonic stem (ES) cells, whose expression is tissue-restricted and/or developmentally regulated. One of the cDNAs, ES18, is preferentially expressed in lymph node and thymus, and contains noteworthy features of transcriptional regulator. The expression of ES18 transcript was selectively regulated during the apoptosis of T-cell thymoma S49.1 induced by several stimuli. Interestingly, the ES18 transcript was differently regulated in the mutually antagonistic process, between dexamethasone- and A23187-induced cell death of T-cells. Moreover, the message level of ES18 was selectively enhanced by staurosporine, a broad protein kinase inhibitor, but not by other protein kinase inhibitors such as GF109203X and H89. In addition, ES18 transcript was induced by C2-ceramide, which is a mediator of both dexamethasone- and staurosporine-induced apoptotic signaling. We further showed that transient overexpression of ES18 in mouse T-cell lymphoma increased the apoptotic cell death. These data suggest that ES18 may be selectively involved in specific apoptotic processes in mouse T-cells. (+info)Functional analysis of TRAIL receptors using monoclonal antibodies. (3/5488)
mAbs were generated against the extracellular domain of the four known TNF-related apoptosis-inducing ligand (TRAIL) receptors and tested on a panel of human melanoma cell lines. The specificity of the mAb permitted a precise evaluation of the TRAIL receptors that induce apoptosis (TRAIL-R1 and -R2) compared with the TRAIL receptors that potentially regulate TRAIL-mediated apoptosis (TRAIL-R3 and -R4). Immobilized anti-TRAIL-R1 or -R2 mAbs were cytotoxic to TRAIL-sensitive tumor cells, whereas tumor cells resistant to recombinant TRAIL were also resistant to these mAbs and only became sensitive when cultured with actinomycin D. The anti-TRAIL-R1 and -R2 mAb-induced death was characterized by the activation of intracellular caspases, which could be blocked by carbobenzyloxy-Val-Ala-Asp (OMe) fluoromethyl ketone (zVAD-fmk) and carbobenzyloxy-Ile-Glu(OMe)-Thr-Asp (OMe) fluoromethyl ketone (zIETD-fmk). When used in solution, one of the anti-TRAIL-R2 mAbs was capable of blocking leucine zipper-human TRAIL binding to TRAIL-R2-expressing cells and prevented TRAIL-induced death of these cells, whereas two of the anti-TRAIL-R1 mAbs could inhibit leucine zipper-human TRAIL binding to TRAIL-R1:Fc. Furthermore, use of the blocking anti-TRAIL-R2 mAb allowed us to demonstrate that the signals transduced through either TRAIL-R1 or TRAIL-R2 were necessary and sufficient to mediate cell death. In contrast, the expression of TRAIL-R3 or TRAIL-R4 did not appear to be a significant factor in determining the resistance or sensitivity of these tumor target cells to the effects of TRAIL. (+info)Involvement of TNF-related apoptosis-inducing ligand in human CD4+ T cell-mediated cytotoxicity. (4/5488)
TNF-related apoptosis-inducing ligand (TRAIL) has been identified as a member of the TNF family that induces apoptosis in a variety of tumor cells, but its physiological functions are largely unknown. In the present study, we examined the expression and function of TRAIL in human CD4+ T cell clones by utilizing newly established anti-human TRAIL mAbs. Human CD4+ T cell clones, HK12 and 4HM1, exhibited perforin-independent and Fas ligand (FasL)-independent cytotoxicity against certain target cells, including T lymphoma (Jurkat) and keratinocyte (HaCaT) cell lines, which are susceptible to TRAIL-mediated cytotoxicity. In contrast to FasL, the expression of which was inducible upon anti-CD3 stimulation, TRAIL was constitutively expressed on HK12 and 4HM1 cells, and no further increase was observed after anti-CD3 stimulation. Spontaneous cytotoxic activities of resting HK12 and 4HM1 cells against Jurkat and HaCaT cells were blocked by anti-TRAIL mAb but not by anti-FasL mAb, and bystander cytotoxic activities of anti-CD3-stimulated HK12 and 4HM1 cells were abolished by the combination of anti-TRAIL and anti-FasL mAbs. These results indicate a differential regulation of TRAIL and FasL expression on human CD4+ T cell clones and that TRAIL constitutes an additional pathway of T cell-mediated cytotoxicity. (+info)The cell death-promoting gene DP5, which interacts with the BCL2 family, is induced during neuronal apoptosis following exposure to amyloid beta protein. (5/5488)
DP5, which contains a BH3 domain, was cloned as a neuronal apoptosis-inducing gene. To confirm that DP5 interacts with members of the Bcl-2 family, 293T cells were transiently co-transfected with DP5 and Bcl-xl cDNA constructs, and immunoprecipitation was carried out. The 30-kDa Bcl-xl was co-immunoprecipitated with Myc-tagged DP5, suggesting that DP5 physically interacts with Bcl-xl in mammalian cells. Previously, we reported that DP5 is induced during neuronal apoptosis in cultured sympathetic neurons. Here, we analyzed DP5 gene expression and the specific interaction of DP5 with Bcl-xl during neuronal death induced by amyloid-beta protein (A beta). DP5 mRNA was induced 6 h after treatment with A beta in cultured rat cortical neurons. The protein encoded by DP5 mRNA showed a specific interaction with Bcl-xl. Induction of DP5 gene expression was blocked by nifedipine, an inhibitor of L-type voltage-dependent calcium channels, and dantrolene, an inhibitor of calcium release from the endoplasmic reticulum. These results suggested that the induction of DP5 mRNA occurs downstream of the increase in cytosolic calcium concentration caused by A beta. Moreover, DP5 specifically interacts with Bcl-xl during neuronal apoptosis following exposure to A beta, and its binding could impair the survival-promoting activities of Bcl-xl. Thus, the induction of DP5 mRNA and the interaction of DP5 and Bcl-xl could play significant roles in neuronal degeneration following exposure to A beta. (+info)TWEAK induces angiogenesis and proliferation of endothelial cells. (6/5488)
TWEAK is a recently described member of the Tumor Necrosis Factor (TNF) ligand family whose transcripts are present in a wide variety of human tissues (Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu Y. M., Scott, H., Hession, C., Garcia, I., and Browning, J. L. (1997) J. Biol. Chem. 272, 32401-32410). TWEAK is a weak inducer of apoptosis in transformed cells when administered with interferon-gamma or cycloheximide (Chicheportiche, Y., Bourdon, P. R., Xu, H., Hsu Y. M., Scott, H., Hession, C., Garcia, I., and Browning, J. L. (1997) J. Biol. Chem. 272, 32401-32410; Masters, S. A., Sheridan, J. P., Pitti, R. M., Brush, A. G., and Ashkenazi, A. (1998) Curr. Biol. 8, 525-528) and also promotes IL-8 secretion in cultured cells. We report here that picomolar concentrations of recombinant soluble TWEAK induce proliferation in a variety of normal human endothelial cells and in aortic smooth muscle cells and reduce culture requirements for serum and growth factors. Blocking antibodies to Vascular Endothelial Growth Factor (VEGF) do not significantly inhibit TWEAK-induced proliferation, indicating that TWEAK does not function indirectly through up-regulation of VEGF. Pellets containing TWEAK induce a strong angiogenic response when implanted in rat corneas, suggesting a role for TWEAK in vasculature formation in vivo. (+info)The ubiquitin-homology protein, DAP-1, associates with tumor necrosis factor receptor (p60) death domain and induces apoptosis. (7/5488)
The tumor necrosis factor receptor, p60 (TNF-R1), transduces death signals via the association of its cytoplasmic domain with several intracellular proteins. By screening a mammalian cDNA library using the yeast two-hybrid cloning technique, we isolated a ubiquitin-homology protein, DAP-1, which specifically interacts with the cytoplasmic death domain of TNF-R1. Sequence analysis reveals that DAP-1 shares striking sequence homology with the yeast SMT3 protein that is essential for the maintenance of chromosome integrity during mitosis (Meluh, P. B., and Koshland, D. (1995) Mol. Biol. Cell 6, 793-807). DAP-1 is nearly identical to PIC1, a protein that interacts with the PML tumor suppressor implicated in acute promyelocytic leukemia (Boddy, M. N., Howe, K., Etkin, L. D., Solomon, E., and Freemont, P. S. (1996) Oncogene 13, 971-982), and the sentrin protein, which associates with the Fas death receptor (Okura, T., Gong, L., Kamitani, T., Wada, T., Okura, I., Wei, C. F., Chang, H. M., and Yeh, E. T. (1996) J. Immunol. 157, 4277-4281). The in vivo interaction between DAP-1 and TNF-R1 was further confirmed in mammalian cells. In transient transfection assays, overexpression of DAP-1 suppresses NF-kappaB/Rel activity in 293T cells, a human kidney embryonic carcinoma cell line. Overexpression of either DAP-1 or sentrin causes apoptosis of TNF-sensitive L929 fibroblast cell line, as well as TNF-resistant osteosarcoma cell line, U2OS. Furthermore, the dominant negative Fas-associated death domain protein (FADD) protein blocks the cell death induced by either DAP-1 or FADD. Collectively, these observations highly suggest a role for DAP-1 in mediating TNF-induced cell death signaling pathways, presumably through the recruitment of FADD death effector. (+info)Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c. (8/5488)
We report on the molecular cloning of a novel human cDNA by its interaction with the splicing factor SRp30c in a yeast two-hybrid screen. This cDNA is predominantly expressed in muscle and encodes a protein that is present in the nucleoplasm and concentrated in nucleoli. It was therefore termed Nop30 (nucleolar protein of 30 kDa). We have also identified a related cDNA with a different carboxyl terminus. Sequencing of the NOP gene demonstrated that both cDNAs are generated by alternative 5' splice site usage from a single gene that consists of four exons, spans at least 1800 nucleotides, and is located on chromosome 16q21-q23. The alternative 5' splice site usage introduces a frameshift creating two different carboxyl termini. The carboxyl terminus of Nop30 is rich in serines and arginines and has been found to target the protein into the nucleus, whereas its isoform is characterized by proline/glutamic acid dipeptides in its carboxyl terminus and is predominantly found in the cytosol. Interaction studies in yeast, in vitro protein interaction assays, and co-immunoprecipitations demonstrated that Nop30 multimerizes and binds to the RS domain of SRp30c but not to other splicing factors tested. Overexpression of Nop30 changes alternative exon usage in preprotachykinin and SRp20 reporter genes, suggesting that Nop30 influences alternative splice site selection in vivo. (+info)
Expression pattern of the apoptosis-stimulating protein of p53 family in p53 + human breast cancer cell lines | Cancer Cell...
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Apoptosis repressor with CARD peptide (ab8372) References
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TP53BP2 tumor protein p53 binding protein 2 [Homo sapiens (human)] - Gene - NCBI
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PDCD5抗体|Abcam中国|Anti-PDCD5抗体(ab75430)
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Tumor suppressor death-associated protein kinase is required for full IL-1β production. - Semantic Scholar
Epigenetic down-regulation of death-associated protein kinase in lung cancers. - Early Detection Research Network
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BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte...
Death-associated protein kinase (DAPK) and signal transduction: blebbing in programmed cell death - Nuffield Department of...
Novel Functions of Death-Associated Protein Kinases through Mitogen-Activated Protein Kinase-Related Signals. - PubMed - NCBI
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Physical and functional interaction between BH3-only protein Hrk and mitochondrial pore-forming protein p32<...
Human DAPK1 / DAP Kinase Protein Recombinant His-GST Met 1-Leu 363 | LSBio
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TranslationBlocker Human Apoptosis regulator BAX siRNA - enQuire BioReagents
Combination Study of Guadecitabine and Pembrolizumab. - Full Text View - ClinicalTrials.gov
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Haroon Rashid on Blurtit
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3 ap3h1 24 signarrays apoptosis 3 ap3h1 24 signarrays Gentaur Molecular Products
Штаны Power Mens Sweatpants | Черный | Puma
Новинки спортивных товаров PUMA в официальном интернет-магазине
Oncomin for Apoptosis from Bagdara Farms
BBC Brain Training Experiment: the Good, the Bad, the Ugly | SharpBrains
YUHSpace: 흰쥐의 배자배양에서 배양 온도의 변화에 의해 유도된 apoptosis II. 온도 변화가 배양 중인 발생 11일 배자에 미치는 영향
PUMA 4100/5100
Sterol regulatory element-binding protein 2
"Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis". The EMBO Journal. 15 (5): 1012-20. ... Sterol regulatory element-binding protein 2 (SREBP-2) also known as sterol regulatory element binding transcription factor 2 ( ... SREBF2 has been shown to interact with INSIG1 and CREB-binding protein. Sterol regulatory element-binding protein GRCh38: ... Nagoshi E, Imamoto N, Sato R, Yoneda Y (Jul 1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic ...
SIVA1
Apoptosis regulatory protein Siva is a protein that in humans is encoded by the SIVA1 gene. This gene encodes a protein with an ... 2000). "Apoptosis in coxsackievirus B3-caused diseases: interaction between the capsid protein VP2 and the proapoptotic protein ... Siva protein is a zinc-containing intracellular ligand of the CD4 receptor that promotes HIV-1 envelope-induced apoptosis in T- ... 2003). "GITR interacts with the pro-apoptotic protein Siva and induces apoptosis". Cell Death Differ. 9 (12): 1382-4. doi: ...
CCAR1
2006). "Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor ... "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis ... 2007). "Transactivator of transcription-tagged cell cycle and apoptosis regulatory protein-1 peptides suppress the growth of ... Cell division cycle and apoptosis regulator protein 1 is a protein that in humans is encoded by the CCAR1 gene. GRCh38: Ensembl ...
Stratifin
"Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis ... Stratifin (also known as 14-3-3 protein sigma or 14-3-3σ protein) is a protein encoded by the SFN gene in humans. The protein ... A member of a protein family that has been involved in the protein kinase C signalling pathway". Journal of Molecular Biology. ... October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. ...
Sandra Quackenbush
Her lab is trying to determine the mode by which transcription, apoptosis, and transduction are controlled by viral regulatory ... Retroviruses within these genera cause disease by containing RNA sequences that code for proteins that promote oncogenesis ... contains sequences that encode for cyclin proteins, leading to the proliferation of normal cells and eventually giving a means ... proteins such as kinases. Studies focus on the walleye dermal sarcoma virus and inducing sarcomas. The retroviral cyclin of ...
Ifi202
... which is a regulatory protein in the process of apoptosis. This is hypothesized to contribute to some of the symptoms of SLE. ... Ifi202 gene encodes for p202 protein, which belongs to the p200-protein family. The IFI family of genes is inducible by type 1 ... The p202 protein has the following structure A 52kDa nuclear phosphoprotein Humans have an ifi202 and ifi204 similar gene known ... p202 seems to bind to p53 protein in the N-terminal region to inhibit p53 function. The expression of p53 appears to inhibit ...
APAF1
This gene encodes a cytoplasmic protein that forms one of the central hubs in the apoptosis regulatory network. This protein ... The protein was identified in the lab of Xiaodong Wang as an activator of caspase-3 in the presense of cytochromeC and dATP. ... Zou H, Henzel WJ, Liu X, Lutschg A, Wang X (Aug 1997). "Apaf-1, a human protein homologous to C. elegans CED-4, participates in ... 78 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 4 (5): 307-13. doi:10.1093/dnares/4.5.307 ...
DAP3
As aforementioned, death associated protein 3 (DAP3) has regulatory roles in cell respiration and apoptosis. Both opposites and ... Miyazaki T, Reed JC (Jun 2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nature ... Miyazaki T, Reed JC (2001). "A GTP-binding adapter protein couples TRAIL receptors to apoptosis-inducing proteins". Nat. ... 28S ribosomal protein S29, mitochondrial, also known as death-associated protein 3 (DAP3), is a protein that in humans is ...
Apoptosis
... apoptotic signals must cause regulatory proteins to initiate the apoptosis pathway. This step allows those signals to cause ... Database of proteins involved in apoptosis Apoptosis Video Apoptosis Video (WEHI on YouTube ) The Mechanisms of Apoptosis ... HIV may increase the level of cellular proteins that prompt Fas-mediated apoptosis. HIV proteins decrease the amount of CD4 ... The adenovirus E1B-55K protein and the hepatitis B virus HBx protein are examples of viral proteins that can perform such a ...
Activating protein 2
Hilger-Eversheim K, Moser M, Schorle H, Buettner R (2000). "Regulatory roles of AP-2 transcription factors in vertebrate ... development, apoptosis and cell-cycle control". Gene. 260 (1-2): 1-12. doi:10.1016/S0378-1119(00)00454-6. PMID 11137286. ... Activating Protein 2 (AP-2) is a family of closely related transcription factors which plays a critical role in regulating gene ... Protein pages needing a picture, Genes on human chromosome 6, Genes on human chromosome 20, Genes on human chromosome 1, Gene ...
TP53-inducible glycolysis and apoptosis regulator
Henley SA, Dick FA (2012). "The retinoblastoma family of proteins and their regulatory functions in the mammalian cell division ... It also prevents apoptosis in several ways: it reduces mitochondrial ROS levels, and it prevents apoptosis-causing protein Bax ... This stops cytochrome C protein passing out through VDAC into the cytoplasm where it triggers apoptosis via a caspase protein ... In this state, Rb binds to a protein transcription factor E2F and prevents E2F from activating transcription of proteins ...
Viral regulatory and accessory protein
"The human immunodeficiency virus type 1 accessory protein Vpu induces apoptosis by suppressing the nuclear factor kappaB- ... A viral regulatory and accessory protein is a type of viral protein that can play an indirect role in the function of a virus. ... Viral+regulatory+and+accessory+proteins at the US National Library of Medicine Medical Subject Headings (MeSH) Akari H, Bour S ... v t e (Viral proteins, All stub articles, Virus stubs). ...
Andrea Hayes-Jordan
1 February 2009). "IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via ... repression of FLICE-like protein expression". Cancer Research. 69 (3): 1080-8. doi:10.1158/0008-5472.CAN-08-2520. ISSN 0008- ... α cooperates with IFN-γ to repress Bcl-xL expression to sensitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis ...
IRF8
Interferon regulatory factor 8 (IRF8) also known as interferon consensus sequence-binding protein (ICSBP), is a protein that in ... "IFN regulatory factor 8 sensitizes soft tissue sarcoma cells to death receptor-initiated apoptosis via repression of FLICE-like ... Interferon Consensus Sequence-binding protein (ICSBP) is a transcription factor of the interferon regulatory factor (IRF) ... "IFN regulatory factor 8 mediates apoptosis in nonhemopoietic tumor cells via regulation of Fas expression". J. Immunol. 179 (7 ...
Regulatory enzyme
... and proteins involved in development processes and apoptosis (programmed cell death) are activated by proteolysis too. ... Phosphorylation is the addition of phosphate groups to proteins, which is the most frequent regulatory modification mechanism ... The presence of a phosphoryl group in a part of a protein may depend on the folding of the enzyme (which can make the protein ... There are many strategies of activation and deactivation of regulatory enzymes. Regulatory enzymes require an extra activation ...
Small integral membrane protein 14
... a regulatory mechanism for apoptosis. It has also been predicted that SMIM14 interacts with LSM4, a glycine-rich protein that ... Small integral membrane protein 14, also known as SMIM14 or C4orf34, is a protein encoded on chromosome 4 of the human genome ... "small integral membrane protein 14 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-04-30. Brendel, V.; ... The predicted molecular weight (Mw) of the SMIM14 protein is 10710.34 Da. The SMIM14 protein carries no electrical charge at a ...
BAG4
The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin ... The protein encoded by this gene is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that ... functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase ... 2001). "Isolation of Bcl-2 binding proteins that exhibit homology with BAG-1 and suppressor of death domains protein". Biochem ...
Pyrin domain
... apoptosis-associated speck-like protein containing a CARD (ASC), regulatory proteins like pyrin or pyrin-only proteins (POPs), ... Proteins that possess a pyrin domain interact with the pyrin domains in other proteins to form of multi-protein complexes ... Bertin J, DiStefano PS (December 2000). "The PYRIN domain: a novel motif found in apoptosis and inflammation proteins". Cell ... Pyrin-only proteins are unlike other PYD-containing proteins which contain a pyrin domain with one or more other domains. ...
NBEAL1
... protein-protein interactions, vesicle trafficking, membrane dynamics, receptor signaling, apoptosis, adaptor/regulatory modules ... "neurobeachin-like protein 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2017-02-24. "Pfam: Family: ... apoptosis, membrane dynamics and receptor signaling. This protein family is of great clinical importance currently because ... Protein pages needing a picture, Genes on human chromosome 2, Human gene pages with Wikidata item, Genes, Human proteins). ...
Viral protein
... and apoptosis. In DNA viruses and retroviruses, viral regulatory proteins can enhance viral gene transcription, likewise, these ... and groups of viral proteins include structural proteins, nonstructural proteins, regulatory proteins, and accessory proteins. ... Viral regulatory and accessory proteins have many functions. These viral proteins control and influence viral gene expressions ... Examples of class II viral fusion proteins include the dengue virus E protein, and the west nile virus E protein. Class III: ...
FADD
Cellular FLICE inhibitory protein (c-FLIP) is a regulatory protein which contains two DEDs. There are two isoforms of C-FLIP: C ... The activity of protein kinase C has a negative effect on Fas receptor mediated apoptosis. This is because it inhibits the ... Binding of TRAIL to death receptors four and five (DR4 and DR5) can lead to apoptosis by the same mechanism. Apoptosis can also ... As FADD has such an important role in apoptosis, loss of FADD can give cancer cells a proliferative advantage as apoptosis ...
CARD9
... and thus plays an important regulatory role in cell apoptosis. This protein was identified by its selective association with ... Caspase recruitment domain-containing protein 9 is an adaptor protein of the CARD-CC protein family, which in humans is encoded ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... Hsu YM, Zhang Y, You Y, Wang D, Li H, Duramad O, Qin XF, Dong C, Lin X (2007). "The adaptor protein CARD9 is required for ...
Robert Schimke
Later he studied regulatory mechanisms in the cells, including the regulation of apoptosis. He was a Research Professor of the ... "Protein Turnover and Gene Amplification". Journal of Biological Chemistry. 282 (e1 2). 27 April 2007. (Articles with hCards, ... At Stanford he examined the effects of steroid hormones on the synthesis of certain proteins, leading to new techniques in ... The mechanism also found applications in biotechnology, for example in the production of proteins, including erythropoietin, of ...
MAPK10
... immunodeficiency virus type 1 and its coat protein gp120 induce apoptosis and activate JNK and ERK mitogen-activated protein ... this kinase plays regulatory roles in the signaling pathways during neuronal apoptosis. Beta-arrestin 2, a receptor-regulated ... a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". ... a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a Scaffold factor in the JNK signaling pathway". ...
DNA damage-inducible transcript 3
CHOP-induced apoptosis can also trigger cell death by inhibiting the expression of cell cycle regulatory protein, p21. The p21 ... Bag5 overexpression inhibited ER stress-induced apoptosis in the unfolded protein response by suppressing PERK-eIF2-ATF4 and ... July 2014). "Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis". Science. 345 (6192 ... October 2010). "The endoplasmic reticulum stress-C/EBP homologous protein pathway-mediated apoptosis in macrophages contributes ...
CIAPIN1
... is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430 ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome ... Anamorsin is a protein that in humans is encoded by the CIAPIN1 gene. ...
Carlos F. López
"Modeling Extrinsic Apoptosis Regulatory Network Pathways Using A Rules-based Framework". scholar.google.com. Retrieved 2022-01- ... Lopez, Carlos F.; Darst, Richard K.; Rossky, Peter J. (2008-05-01). "Mechanistic Elements of Protein Cold Denaturation". The ... Colegio San Carlos Yearbook Class of 1993, retrieved 2022-01-22 "Studies of membrane and membrane protein systems using ...
Discovery and development of bisphosphonates
Isoprenoid lipids are necessary for post-translational modifications of small GTP-binding regulatory proteins like Rac, Rho and ... The function of osteoclasts depends on them for a variety of cellular processes like apoptosis. Bisphosphonates mimic the ... Coxon, F.P.; Rogers, M.J. (2003-01-01). "The Role of Prenylated Small GTP-Binding Proteins in the Regulation of Osteoclast ... The primary inhibiting action of the first generation of bisphosphonates on osteoclasts is by inducing apoptosis. The mechanism ...
Betulin
In another study, betulin inhibited the maturation of sterol regulatory element-binding protein (SREBPs). Inhibition of SREBP ... Betulin causes some types of tumor cells to start a process of self-destruction called apoptosis, and can slow the growth of ...
CD47
2012). "The CD47-signal regulatory protein alpha (SIRPα) interaction is a therapeutic target for human solid tumors". Proc. ... However, apoptosis was not observed following culture with other anti-CD47 antibodies. The apoptosis inducing function of CD47 ... CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells. The ... Barclay AN (February 2009). "Signal regulatory protein alpha (SIRPα)/CD47 interaction and function". Curr. Opin. Immunol. 21 (1 ...
G1 phase
In these cases where the G1 phase is affected, it is generally because gene regulatory proteins of the E2F family have become ... "Atractylenolide II induces G1 cell-cycle arrest and apoptosis in B16 melanoma cells". Journal of Ethnopharmacology. 136 (1): ... the cell grows in size and synthesizes mRNA and protein that are required for DNA synthesis. Once the required proteins and ... In this part of interphase, the cell synthesizes mRNA and proteins in preparation for subsequent steps leading to mitosis. G1 ...
PSMD7
The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, ... signal transduction and apoptosis. Subsequently, a compromised proteasome complex assembly and function lead to reduced ... some key regulatory proteins fulfill their biological functions via selective degradation; furthermore, proteins are digested ... The human protein 26S proteasome non-ATPase regulatory subunit 14 is 37 kDa in size and composed of 324 amino acids. The ...
HSPA1B
Heat shock 70kDa protein 1B is a chaperone protein, cooperating with other heat shock proteins and chaperone systems to ... August 2013). "The ubiquitin ligase Stub1 negatively modulates regulatory T cell suppressive activity by promoting degradation ... and inhibition of apoptosis in ovarian, bladder urothelial, and breast cancers. Patients with chronic hepatitis B or hepatitis ... Expression of heat shock protein 70kDa protein 2 in transformed tumor cells has been implicated in the rapid proliferation, ...
Clonal deletion
In immunology, clonal deletion is the removal through apoptosis of B cells and T cells that have expressed receptors for self ... This helps eliminate autoreactive T cells that recognize a protein from a specific body part. Complete clonal deletion results ... there are mechanisms in the periphery involving T regulatory cells to prevent the host from obtaining an autoimmune disease. ... Incomplete clonal deletion results in apoptosis of most autoreactive B and T lymphocytes. Complete clonal deletion can lead to ...
Interferon
Some viruses can encode proteins that bind to double-stranded RNA (dsRNA) to prevent the activity of RNA-dependent protein ... They also limit viral spread by increasing p53 activity, which kills virus-infected cells by promoting apoptosis. The effect of ... Binding of ISGF3 and other transcriptional complexes activated by IFN signaling to these specific regulatory elements induces ... the E7 protein of Human papillomavirus (HPV), and the B18R protein of vaccinia virus. Reducing IFN-α activity may prevent ...
ABL (gene)
Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL ... "BCR sequences essential for transformation by the BCR-ABL oncogene bind to the ABL SH2 regulatory domain in a non- ... "Interaction of c-Abl and p73alpha and their collaboration to induce apoptosis". Nature. 399 (6738): 809-13. Bibcode:1999Natur. ... Welch PJ, Wang JY (November 1993). "A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl ...
Caspase 10
... and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II ... "The death effector domain-associated factor plays distinct regulatory roles in the nucleus and cytoplasm". J. Biol. Chem. ... "Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria". J. Biol. Chem. United States. 277 (16): ... This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of ...
Cell cycle
Checkpoints typically consist of a network of regulatory proteins that monitor and dictate the progression of the cell through ... Thus there is a net increase in cell number as the number of cells that die by apoptosis or senescence remains the same. The ... Henley SA, Dick FA (March 2012). "The retinoblastoma family of proteins and their regulatory functions in the mammalian cell ... Two families of genes, the cip/kip (CDK interacting protein/Kinase inhibitory protein) family and the INK4a/ARF (Inhibitor of ...
Galectin-9
... factor-related apoptosis-inducing ligand activates a lysosomal pathway of apoptosis that is regulated by Bcl-2 proteins". The ... Liu FT (April 2005). "Regulatory roles of galectins in the immune response". International Archives of Allergy and Immunology. ... The protein has N- and C- terminal carbohydrate-binding domains connected by a link peptide. Multiple alternatively spliced ... However, it can also interact with other proteins (CLEC7A, CD137, CD40). For example, an interaction with CD40 on T-cells ...
Thromboxane-A synthase
However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than ... and interaction of transcriptional regulatory factor with its DNA element in the 5' flanking region". Biochim. Biophys. Acta. ... apoptosis inhibition, angiogenesis, and metastasis. Thromboxane synthesis Eicosanoid synthesis Prostanoid 12- ... First, there is a fast initial binding to the protein and then a subsequent ligation to the heme iron. In the first step of the ...
Phosphatidylinositol 3,4-bisphosphate
PI(3,4)P2 plays another possible role at the PM, promoting cytoskeletal rearrangements through actin regulatory proteins like ... Akt activation causes downstream metabolism alterations, apoptosis suppression and a rise in cell proliferation. This pathway ... Following this release, T308 in the proteins activation loop and S437 in the proteins hydrophobic domain are phosphorylated by ... Characterization of a 3- phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα. ...
RNA-targeting small molecule drugs
They hypothesized that RNA could be "druggable" by targeting the 3D structure in the same way as protein 3D structures are used ... Further, these compounds were shown to suppress the KRAS oncogene in pancreatic cancer cells and induce apoptosis by reducing ... They identified a hit compound that was selective for the regulatory sequence with micromolar binding affinity. In 2011, ... Zapp, Maria L; Stern, Seth; Green, Michael R (1993). "Small molecules that selectively block RNA binding of HIV-1 rev protein ...
Glucocorticoid receptor
... the heat shock protein 70 (hsp70) and the protein FKBP4 (FK506-binding protein 4). The endogenous glucocorticoid hormone ... N-terminal regulatory domain C - DNA-binding domain (DBD) D - hinge region E - ligand-binding domain (LBD) F - C-terminal ... "RAP46 is a negative regulator of glucocorticoid receptor action and hormone-induced apoptosis". The Journal of Biological ... Hulkko SM, Wakui H, Zilliacus J (August 2000). "The pro-apoptotic protein death-associated protein 3 (DAP3) interacts with the ...
PSMB3
... including damaged proteins for protein quality control purpose or key regulatory protein components for dynamic biological ... signal transduction and apoptosis. Subsequently, a compromised proteasome complex assembly and function lead to reduced ... "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes". ... This protein is one of the 17 essential subunits that contribute to the complete assembly of the 20S proteasome complex. In ...
Prostate cancer
"Expression of X-linked inhibitor of apoptosis protein in human prostate cancer specimens with and without neo-adjuvant hormonal ... This region encompasses regulatory elements, non-coding genes, and the stem cell related POU5F1B gene. Roughly 4% of families ... Transport protein ZIP1 is responsible for the transport of zinc into prostate cells. One of zinc's important roles is to change ... X-linked inhibitor of apoptosis (XIAP) is hypothesized to promote cancer cell survival and growth, the Macrophage inhibitory ...
AP-1 transcription factor
... in the levels of Jun and Fos proteins and JNK activity have been reported in scenarios in which cells undergo apoptosis. For ... Due to the AP-1 regulatory functions in cancer cells, AP-1 modulation is studied as a potential strategy for cancer prevention ... Masuda A, Yoshikai Y, Kume H, Matsuguchi T (November 2004). "The interaction between GATA proteins and activator protein-1 ... "Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s)". The Journal of General Virology. 80 ( ...
Index of biochemistry articles
... nuclear protein - nucleic acid - nucleic acid regulatory sequence - nucleic acid repetitive sequence - nucleic acid sequence ... apoptosis - aquaporin - archaea - arginine - argipressin - aromatic amine - aromatic compound - arrestin - Arrhenius equation ... protein - protein biosynthesis - Protein Data Bank - protein design - protein expression - protein folding - protein isoform - ... protein P16 - protein P34cdc2 - protein precursor - protein structure prediction - protein subunit - protein synthesis - ...
Placenta specific 8
... is a protein that in humans is encoded by the PLAC8 gene. GRCh38: Ensembl release 89: ENSG00000145287 - ... Mourtada-Maarabouni M, Watson D, Munir M, Farzaneh F, Williams GT (2013). "Apoptosis suppression by candidate oncogene PLAC8 is ... Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory ... Uehara H, Takahashi T, Izumi K (2013). "Induction of retinol-binding protein 4 and placenta-specific 8 expression in human ...
TMEM125
In a topological transcriptome analysis, researchers profiled important proteins of the non-small cell lung cancer regulatory ... Additionally, its myristoylation sites suggests its involvement in signal transduction, apoptosis, and alternative ... Transmembrane protein 125 is a protein that, in humans, is encoded by the TMEM125 gene. It has 4 transmembrane domains and is ... String Protein Interaction predicted 10 functional protein partners for TMEM125, but all were determined through textmining. ...
Semaglutide
It is the first glucagon-like peptide receptor protein treatment approved for use in the United States that does not need to be ... "Regulatory Decision Summary - Ozempic". Health Canada. 23 October 2014. Archived from the original on 17 May 2019. Retrieved 2 ... "Glucagon-like Peptide-1 Receptor Signaling Modulates β Cell Apoptosis". The Journal of Biological Chemistry. 278 (1): 471-478. ... "Regulatory Decision Summary - Rybelsus". Health Canada. 23 October 2014. Archived from the original on 5 June 2022. Retrieved 4 ...
Obesity and fertility
However, the regulatory functions of the HPO can be disrupted due to the up or down regulation of certain hormones in the ... Adiponectin, the protein secreted in greatest amounts from adipocytes, functions to increase the sensitivity of cells to ... leading to apoptosis. This process is known as lipotoxicity. Lipotoxicity can impair follicular development, lead to errors in ... Adipocytes (fat cells) secrete proteins and signaling molecules known as adipokines. Certain adipokines have been implicated in ...
PPP1R15A
Protein phosphatase 1 regulatory subunit 15A also known as growth arrest and DNA damage-inducible protein GADD34 is a protein ... 2000). "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins". ... "Leukemic HRX fusion proteins inhibit GADD34-induced apoptosis and associate with the GADD34 and hSNF5/INI1 proteins". Mol. Cell ... "Entrez Gene: PPP1R15A protein phosphatase 1, regulatory (inhibitor) subunit 15A". Zhan Q, Lord KA, Alamo I, Hollander MC, ...
PHACTR1
A family of protein phosphatase 1 and actin regulatory proteins". Proceedings of the National Academy of Sciences of the United ... of the novel protein PHACTR-1 from human endothelial cells abolishes tube formation and induces cell death receptor apoptosis ... PHACTR1 is an actin and protein phosphatase 1 (PP1) binding protein that binds actin and regulates the reorganization of the ... PHACTR1 is a PP1 binding protein, which is reported to be highly expressed in brain and which controls PP1 activity and F-actin ...
Nuclear receptor 4A3
"The homeotic protein Six3 is a coactivator of the nuclear receptor NOR-1 and a corepressor of the fusion protein EWS/NOR-1 in ... NR4A3 plays a central regulatory role in cell proliferation, differentiation, mitochondrial respiration, metabolism and ... apoptosis NR4A3 has been shown to interact with SIX3. NUR nuclear receptor family GRCh38: Ensembl release 89: ENSG00000119508 ... NR4A3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) v t e (Articles with short ...
Chromosome 16
Cytokine induced apoptosis inhibitor 1) CKLF: Chemokine-like factor CLUAP1: CMTM2: encoding protein CKLF-like MARVEL ... encoding protein Pyruvate dehydrogenase phosphatase regulatory subunit PKDTS: Polycystic kidney disease, infantile severe, with ... encoding protein NIP30 protein NOB1: encoding protein RNA-binding protein NOB1 NOMO1: encoding protein Nodal modulator 1 NPW: ... encoding protein Zinc finger protein 23 ZNF200: encoding protein Zinc finger protein 200 ZNF263: encoding protein Zinc finger ...
Artificial transcription factor
... and the number of activating or repressing sequences present in the regulatory domain. Activating domains, regulatory domains ... Natural DNA binding proteins are commonly used because of their high affinity for their DNA target sequence, however currently ... and ATFs linked to activator domains can upregulate Bax gene expression causing cell apoptosis; however, these treatments ... The regulatory domain is responsible for activating or repressing the bound gene and accomplishes this regulation by either ...
Caretaker gene
Some key caretaker proteins that contribute to cell survival by acting in DNA repair processes when the level of damage is ... Cells defective in apoptosis tend to survive even with excessive DNA damage, thus permitting replication of the damaged DNA and ... This is because of the regulatory function associated with caretaker genes in maintaining the stability of the genome. The ... Gatekeeper genes regulate apoptosis. However, in instances where tissue growth or regrowth is warranted, these signals must be ...
Belimumab
... who jointly published a paper detailing their findings in May 1999 and named the protein TALL-1. The same protein was named ... Regulatory agencies recommend that patients be treated with an antihistamine prior to a belimumab infusion. Because belimumab ... When autoimmune B cells attack the body's own tissues, they are normally destroyed by cell suicide (apoptosis). Researchers ... BR3-Fc, a recombinant fusion protein built with the extracellular ligand-binding portion of BAFF-R, blocks activation of this ...
Nuclear receptor 4A1
Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple alternatively spliced variants, ... "Identification of nerve growth factor-responsive element of the TCL1 promoter as a novel negative regulatory element". The ... Liu S, Wu Q, Ye XF, Cai JH, Huang ZW, Su WJ (June 2002). "Induction of apoptosis by TPA and VP-16 is through translocation of ... Wu Q, Liu S, Ye XF, Huang ZW, Su WJ (October 2002). "Dual roles of Nur77 in selective regulation of apoptosis and cell cycle by ...
Epigenetic therapy
Histones are proteins which are involved in the folding and compaction of the chromatin. There are several different types of ... MMP-9 is believed to be involved in cellular apoptosis, and is similarly downregulated, which may help to propagate the effects ... The final category of epigenetic mechanism is regulatory RNA. MicroRNAs are small, noncoding sequences that are involved in ... In general, DNA methylation attracts proteins which fold that section of the chromatin and repress the related genes. The ...
AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages
Aim2 protein, mouse * Apoptosis Regulatory Proteins * CARD Signaling Adaptor Proteins * Cytokines * Cytoskeletal Proteins ... AIM2/ASC triggers caspase-8-dependent apoptosis in Francisella-infected caspase-1-deficient macrophages Cell Death Differ. 2012 ... Furthermore, we demonstrate that caspase-1-independent apoptosis requires the activation of caspase-9 and of the intrinsic ... Francisella tularensis, the agent of tularaemia, triggers AIM2/ASC-dependent caspase-3-mediated apoptosis in caspase-1- ...
Langerhans Cell Histiocytosis Treatment & Management: Medical Care, Consultations
Marchal J, Kambouchner M, Tazi A, Valeyre D, Soler P. Expression of apoptosis-regulatory proteins in lesions of pulmonary ... Immunohistochemical detection of the apoptosis-related proteins FADD, FLICE, and FLIP in Langerhans cell histiocytosis. J ... Senechal B, Elain G, Jeziorski E, Grondin V, Patey-Mariaud de Serre N, Jaubert F. Expansion of regulatory T cells in patients ... Foxp3+ Tregs from Langerhans cell histiocytosis lesions co-express CD56 and have a definitively regulatory capacity. Clin ...
Search Results (199) | Profiles RNS
NIOSHTIC-2 Search Results - Full View
SMART: Secondary literature for DBC1 domain
Cell cycle- and apoptosis-regulatory protein-1 is involved in apoptosis signaling by epidermal growth factor receptor. ... Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 (aka CCAR1) is a novel transducer of signaling by diverse agents including ... Cell cycle and apoptosis regulatory protein (CARP)-1 is expressed in osteoblasts and regulated by PTH. ... Parathyroid hormone (PTH) controls osteoblast cell cycle regulatory proteins and suppresses mature osteoblasts apoptosis. ...
The baculovirus anti-apoptotic protein Op-IAP does not inhibit Drosophila caspases or apoptosis in Drosophila S2 cells and...
Apoptosis Regulatory Proteins Medicine & Life Sciences 98% * Caspases Medicine & Life Sciences 84% ... However, the mechanism by which Op-IAP inhibits apoptosis is unclear. Since some IAP proteins can bind and inhibit caspases, we ... However, the mechanism by which Op-IAP inhibits apoptosis is unclear. Since some IAP proteins can bind and inhibit caspases, we ... However, the mechanism by which Op-IAP inhibits apoptosis is unclear. Since some IAP proteins can bind and inhibit caspases, we ...
Professor Kenneth Ashwell
Krajewski SJ; Mai JK; Ashwell KW; Reed JC; Zapata JM, 1999, The dynamic of expression for apoptosis-regulatory proteins (BCL-2 ... Dyanmics of Expression of Apoptosis-Regulatory Proteins Bid, BC1-2, BC1-X, Bax and Bak during development of murine nervous ... Dynamics of expression of apoptosis-regulatory proteins Bid, Bcl-2, Bcl-X, Bax and Bak during development of murine nervous ... Expression of apoptosis-related proteins and structural features of cell death in explanted aortocoronary saphenous vein bypass ...
Pesquisa | Portal Regional da BVS
Moreover, compound I-33 (MY-875) could regulate the levels of cell cycle and apoptosis regulatory proteins in MGC-803 and SGC- ... Protein-protein interactions play a crucial role in microtubule dynamics. Microtubules are considered as a key target for the ... Moreover, the significant down-regulation in the levels of Bcl-2 protein and up-regulated levels of proteins, such as Bax, p53 ... indicated that 9e can induce apoptosis via mitochondria-dependent apoptosis pathway. Additionally, 9e can also cause ER stress ...
CometAssay Electrophoresis Starter Kit 4250-050-ESK: R&D Systems
The anti-apoptotic BCL-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages - Fingerprint - National...
CARD Signaling Adaptor Proteins | Profiles RNS
Apoptosis Regulatory Proteins [D12.644.360.075]. *CARD Signaling Adaptor Proteins [D12.644.360.075.358] ... CARD Signaling Adaptor Proteins*CARD Signaling Adaptor Proteins. *Caspase Activation and Recruitment Domain Signaling Proteins ... Proteins that contain this domain play a role in APOPTOSIS-related signal transduction by associating with other CARD domain- ... "CARD Signaling Adaptor Proteins" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ...
MeSH Browser
2017; BCL-2-LIKE PROTEIN 11 was indexed under MEMBRANE PROTEINS; PROTO-ONCOGENE PROTEINS; APOPTOSIS REGULATORY PROTEINS 2005- ... Apoptosis Regulatory Proteins [D12.644.360.075] * Apoptosis Inducing Factor [D12.644.360.075.311] * Bcl-2-Like Protein 11 [ ... Apoptosis Regulatory Proteins [D12.776.476.075] * Apoptosis Inducing Factor [D12.776.476.075.311] * Bcl-2-Like Protein 11 [ ... Proteins [D12.776] * Neoplasm Proteins [D12.776.624] * Oncogene Proteins [D12.776.624.664] * Proto-Oncogene Proteins [D12.776. ...
Connection | Profiles RNS
Faculty of Public Health - Research output - Universitas Indonesia
Vice-President - Research output - Keio University
Génétique - génomique - Résultat de recherche - Portail de la recherche de l'Université de Namur
Hypoxia-induced modulation of apoptosis and BCL-2 family proteins in different cancer cell types. Sermeus, A., Genin, M., ... ATF4 activation regulates autophagy and inhibits apoptosis. Notte, A., Rebucci, M., Fransolet, M., Roegiers, E., Genin, M., ... A p38MAPK/HIF-1 pathway initiated by UVB irradiation is required to induce Noxa and apoptosis of human keratinocytes. Nys, K., ... Hypoxia protects HepG2 cells against etoposide-induced apoptosis VIA a HIF-1-independent pathway. Piret, J-P., Cosse, J-P., ...
Inductive patterning of the embryonic brain in Drosophila | Development | The Company of Biologists
4A). This correlates with previous observations regarding the expression of the apoptosis regulatory protein Reaper (Nassif et ... Loss of Hedgehog function results in changes in apoptosis. To see if changes in apoptosis underlie the b1 dorsal midline ... Changes in apoptosis associated with brain patterning defects. All embryos are at late ES13, and are view dorsally at the level ... Changes in apoptosis associated with brain patterning defects. All embryos are at late ES13, and are view dorsally at the level ...
DeCS
Protein, Apoptosis Regulatory Regulatory Protein, Apoptosis Regulatory Proteins, Apoptosis Apoptosis Inducing Proteins - ... Apoptosis Inducing Proteins. Apoptosis Inhibiting Protein. Apoptosis Inhibiting Proteins. Apoptosis Regulatory Protein. Death ... Protein, Anti-Apoptotic. Protein, Apoptosis Inducing. Protein, Apoptosis Inhibiting. Protein, Apoptosis Regulatory. Protein, ... Proteins, Apoptosis Inhibiting. Proteins, Pro-Apoptotic. Regulatory Protein, Apoptosis. Regulatory Proteins, Apoptosis. ...
CASP8 and FADD-Like Apoptosis Regulating Protein | Profiles RNS
CASP8 and FADD-Like Apoptosis Regulating Protein [D12.644.360.024.500.024]. *Apoptosis Regulatory Proteins [D12.644.360.075] ... CASP8 and FADD-Like Apoptosis Regulating Protein*CASP8 and FADD-Like Apoptosis Regulating Protein ... Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.024.285]. *CASP8 and FADD-Like Apoptosis Regulating Protein [ ... Death Domain Receptor Signaling Adaptor Proteins [D12.644.360.075.421]. *CASP8 and FADD-Like Apoptosis Regulating Protein [ ...
The Alternative NFkB Pathway in Survival and Function of Anti-Viral T Cells
- Oregon Health & Science University
IMSEAR at SEARO: Search
Proteomic profiles of unilateral cryptorchidism in pigs at different ages using MALDI-TOF mass spectrometry and in-gel...
Using the STITCH database, this protein was found to be related to apoptosis, corresponding to the previous report in the UDTs ... Western blot analysis was used to verify protein expression. Protein sequence was affirmed by liquid chromatography-tandem mass ... A number of markedly expressed proteins from GeLC-MS/MS were identified, including the multifunctional tumor necrosis factor ... The present study revealed the specific PMFs and clusters for porcine cryptorchidism, and a novel protein, TNFRSF18, associated ...
The Tumorigenic Roles of the Cellular REDOX Regulatory Systems
We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that ... The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, ... V. Modur, R. Nagarajan, B. M. Evers, and J. Milbrandt, "FOXO proteins regulate tumor necrosis factor-related apoptosis inducing ... as well as REDOX regulatory systems that recycle/reactivate the ROS scavenging proteins and other REDOX sensitive proteins (e.g ...
The influence of fibronectin on proliferation and apoptosis of acute lymphoblastic leukaemia cells in vitro
The influence of the remaining ECM proteins on proliferation and apoptosis of leukaemia cells did not show a unique regulatory ... In an analysis of 10 cultures of leukaemia cells isolated from patients, the effect of ECM proteins on late apoptosis was noted ... The results of this study suggest the regulatory effect of fibronectin, collagens, and laminin from ECM proteins on acute ... Apoptosis induction. The assay of early apoptosis based on annexin V staining did not show differences between medium and ...
MakCHS Publications | Makerere University College Of Health Sciences | MakCHS
A Four-gene Decision Tree Signature Classification of Triple-negative Breast Cancer: Implications for Targeted Therapeutics.
sg:pub.10.1186/bcr3153 - Springer Nature SciGraph
"Apoptosis Regulatory Proteins", "type": "DefinedTerm" }, { "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", "name": "Bcl-2- ... ", "protein kinase MEK1", "pro-apoptotic protein Bim", "Bcl-2 family member Bim", "caspase-dependent apoptosis", "apoptotic ... and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim ... and antiprogestin-induced apoptosis in ER+ breast cancer cells by MEK1 regulation of the BH3-only pro-apoptotic protein Bim", " ...
Mamoru Oouchida - Research output - Okayama University
Inhibition of apoptosis by normal and aberrant Fli-1 and erg proteins involved in human solid tumors and leukemias. Yi, H. K., ... HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3. Toyooka, S. I., Ouchida, M., Jitsumori, Y., ... Proteomics-based analysis of invasion-related proteins in malignant gliomas. Maruo, T., Ichikawa, T., Kanzaki, H., Inoue, S., ... Recent progress in the protein-tyrosine phosphatase SHP1 gene: the significant correlation of the SHP1 gene silencing with the ...
Expression and location of pro-apoptotic bcl-2 family protein BAD in normal human tissues and tumor cell lines - Fingerprint ...
Apoptosis Regulatory Proteins 10% * National Cancer Institute (U.S.) 10% * Organelles 8% ... Dive into the research topics of Expression and location of pro-apoptotic bcl-2 family protein BAD in normal human tissues and ... Expression and location of pro-apoptotic bcl-2 family protein BAD in normal human tissues and tumor cell lines. ...
Adaptor ProteinsPathwayInducesInhibitorGenesDamage induced apoptosisSignal transductionPeptidesPhosphorylationCellsRegulationTranscriptionTumorRole in regulatinInhibitionHighly conservedPathwaysCytokinesAnti-apoptotic proteinsCellularOxidativeOnset of apoptosisProliferation and apoptosisRegulatorMitochondrial-apoptosisSuppressesDegradationEpigeneticCaspase-dependentMoleculesRegulatesCaspasesKinaseAmino AcidsMechanismAutophagyMRNADifferentiationBcl2PeptideAssay KitApoptoticRecombinantScaffoldMeSHActivationMutations
Adaptor Proteins5
- CARD Signaling Adaptor Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uams.edu)
- A family of intracellular signaling adaptor proteins that contain caspase activation and recruitment domains. (uams.edu)
- This graph shows the total number of publications written about "CARD Signaling Adaptor Proteins" by people in UAMS Profiles by year, and whether "CARD Signaling Adaptor Proteins" was a major or minor topic of these publications. (uams.edu)
- Below are the most recent publications written about "CARD Signaling Adaptor Proteins" by people in Profiles over the past ten years. (uams.edu)
- Activation of this enzyme can occur via the interaction of its N-terminal death effector domain with DEATH DOMAIN RECEPTOR SIGNALING ADAPTOR PROTEINS. (rush.edu)
Pathway20
- Furthermore, we demonstrate that caspase-1-independent apoptosis requires the activation of caspase-9 and of the intrinsic pathway in a typical type II cell manner. (nih.gov)
- This work underscores the crosstalk between inflammasome components and the apoptotic machinery and highlights the versatility of the pathway, which can switch from pyroptosis to apoptosis. (nih.gov)
- Bcl-2 is a key apoptosis regulatory protein of the mitochondrial death pathway whose function is dependent on its expression levels. (cdc.gov)
- In contrast, SB203580, p38 inhibitor, attenuated PTH down-regulation of CARP-1 suggesting that PTH utilized an Extracellular Signal Regulated Kinase (ERK)-independent but p38 dependent pathway to regulate CARP-1 protein expression in osteoblasts. (embl-heidelberg.de)
- The Op-IAP protein from the baculovirus Orgyia pseudotsugata M nucleopolyhedrovirus (OpMNPV) is highly effective at inhibiting apoptosis triggered by a variety of different stimuli in lepidopteran cells as well as in several different mammalian cell types, suggesting that it functions at a highly conserved step in the apoptotic pathway. (utmb.edu)
- Meshki J, Caino MC, von Burstin VA, Griner E, Kazanietz MG. Regulation of prostate cancer cell survival by protein kinase Cepsilon involves bad phosphorylation and modulation of the TNFalpha/JNK pathway. (ucdenver.edu)
- The working hypothesis of this proposal is that sustained activation of the alternative NFkB pathway in proliferating T cells in response to late costimulatory signals induces and maintains expression of the cytokines, cytokine receptors, and anti-apoptotic proteins that are necessary for responding T cells to function as differentiated effector cells and survive as memory cells. (elsevier.com)
- Importantly, small-molecule inhibitors of MEK1 circumvented the prosurvival action of IGF-1 by restoring Bim to levels that more effectively mediated apoptosis in ER+ breast cancer cells.Conclusionhis study provides strong support for the use of MEK1 inhibitors in combination with hormonal therapy to effectively affect cytostasis and activate a Bim-dependent apoptotic pathway in ER+ breast cancer cells. (springernature.com)
- Death-associated protein 3 (DAP3) is an important component of the external apoptosis pathway. (bl.uk)
- L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway. (rush.edu)
- We have previously demonstrated that activation of the PI3K signaling pathway by zinc stimulates the intestinal iron uptake and transport by stimulating the expression of iron regulatory protein 2 (IRP2) dependent divalent metal iron transporter 1 (DMT1, apical iron transporter) expression and caudal-related homeobox transcription factor 2 (CDX2) dependent hephaestin (HEPH, basolateral ferroxidase required for iron oxidation) expression, respectively. (bvsalud.org)
- In conclusion, Res inhibited cardiac hypertrophy via downregulation of the apoptosis signaling pathway and upregulating the autophagy pathway. (spandidos-publications.com)
- cep-1 acts as a transcription activator in a primordial p53 pathway that involves CEP-1 activation and the CEP-1 dependent transcriptional induction of the worm BH3 only domain encoding genes egl-1 and ced-13 to induce germ cell apoptosis. (omicsdi.org)
- RASSF1A elicits apoptosis through an MST2 pathway directing proapoptotic transcription by the p73 tumor suppressor protein. (ox.ac.uk)
- In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)
- The replication of adenovirus in cells activates the TP53-mediated apoptosis pathway. (medicaltrend.org)
- Most patients with atypical HUS have mutations in one or more of the genes that encode proteins involved in the alternate pathway of complement, which creates a predisposition to the disorder. (medscape.com)
- Interference of STAT 5b expression by siRNA targeting enhanced the chemo-sensitivity of gastric cancer cells to gefitinib by promoting mitochondrial pathway-mediated cell apoptosis. (cusabio.com)
- Among the signaling pathways regulated by GSK3s, the Wnt canonical pathway is the most well described, with GSK3β inhibition triggering an increase in β -catenin protein levels and its nuclear translocation to activate target gene expression ( Doble and Woodgett, 2003 ). (eneuro.org)
- Co-expression analysis of these DEGs represented a complex regulatory network, including the jasmonic acid and gibberellin pathway, involved in drought stress tolerance in H471. (biomedcentral.com)
Induces6
- The photoconjugation of psoralens with DNA produces an antiproliferative reaction in the skin, generates programmed cell death (apoptosis), and induces down-regulation of the cutaneous immune system. (medscape.com)
- FasL induces early apoptosis of activated T cells by interfering with anti-apoptotic signals. (jefferson.edu)
- Dysregulation of apoptosis induces a variety of diseases, including cancers, autoimmune diseases, and neurodegenerative diseases [ 3 - 5 ]. (plos.org)
- Details] Repetitive exposure to a 60-Hz time-varying magnetic field induces DNA double-strand breaks and apoptosis in human cells [med. (emf-portal.org)
- The various markers that enable assessment of the progression of preneoplastic lesions to spindle cell carcinoma include the p16 protein, which halts the cell cycle and induces apoptosis by pRb-mediated phosphorylation of cyclin-dependent kinase 4 (CDK4). (bvsalud.org)
- Whether sustained normocortisolism induced by medical therapy induces re-expression of functional sst 2 protein in corticotroph adenomas and whether this increases the ACTH-lowering potency of octreotide remains to be established. (webpediatrica.com)
Inhibitor5
- H-89, a Protein Kinase A (PKA) inhibitor, suppressed PTH action on CARP-1 protein expression indicating PKA-dependent mechanism. (embl-heidelberg.de)
- PMA, a Protein Kinase C (PKC) agonist, mimicked PTH action, and the PKC inhibitor, GF109203X, partially blocked PTH-dependent downregulation of CARP-1, implying involvement of PKC. (embl-heidelberg.de)
- U0126, a Mitogen-Activated Protein Kinase (MAPK) Kinase (MEK) inhibitor, failed to interfere with CARP-1 suppression by PTH. (embl-heidelberg.de)
- As Bromodomain and Extra Terminal (BET) protein inhibitors promote pro-apoptotic rebalancing, we evaluated the potential of the BET inhibitor JQ1 in combination with ABT-199, A-1331852 or S63845 in rhabdomyosarcoma (RMS) cells. (prinsesmaximacentrum.nl)
- Cystatin A (Cys A), a cysteine protease inhibitor, is a precursor of proteins involves in keratinocyte keratinization, and is expressed during the late phase of differentiation of these cells. (bvsalud.org)
Genes13
- In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. (tocris.com)
- We performed genome-wide gene expression analyses which indicate that only a surprisingly small number of genes are regulated by CEP-1 and that DNA damage induced apoptosis via the transcriptional induction of BH3 domain proteins is likely to be an ancient DNA damage response function of the p53 family. (omicsdi.org)
- We showed that loss of Dmp18 disrupted eye and wing development, up-regulated transcription of pro-apoptotic genes, and induced apoptosis. (plos.org)
- Transcriptional induction of pro-apoptotic genes is sufficient to induce apoptosis in Drosophila . (plos.org)
- In the current study, we identified that Dmp18, the homolog of Znhit1, regulates apoptosis by mediating the histone variant H2Av incorporation and H3K4me3 as well as H3K27me3 modifications around the transcription start site (TSS) regions of pro-apoptotic genes. (plos.org)
- The E2F family of transcription factors regulates the expression of a number of genes whose products are involved in cell cycle control, DNA replication and apoptosis. (ox.ac.uk)
- We show here that E2F-1 binds in vivo the promoters of ASPP1 and ASPP2 genes, two activators of p53-mediated apoptosis, E2F-1, E2F-2 and E2F-3 all activate the isolated ASPP1 and ASPP2 promoters. (ox.ac.uk)
- The identification of ASPP1 and ASPP2 genes as transcriptional targets of E2F provides another mechanism by which E2F cooperates with p53 to induce apoptosis. (ox.ac.uk)
- These genes provide instructions for making proteins that are part of essential chemical signaling pathways within cells. (medlineplus.gov)
- The STAT proteins bind to regulatory regions near genes, which allows the proteins to control whether these genes are turned on or off. (medlineplus.gov)
- Changes in the STAT3 gene that cause AD-HIES alter the structure and function of the STAT3 protein, impairing its ability to control the activity of other genes. (medlineplus.gov)
- This domain occurred 318 times on human genes ( 726 proteins). (umbc.edu)
- 12]. MicroRNAs (miRNAs, miRs) are brief, non-coding RNAs that work as detrimental regulators of appearance of protein-encoding genes by annealing to complementary sequences in 3 untranslated locations (3UTRs) of mRNAs and inhibiting additional steps of proteins synthesis [13]. (euromed2016.com)
Damage induced apoptosis4
- Chk2 and REGgamma-dependent DBC1 regulation in DNA damage induced apoptosis. (embl-heidelberg.de)
- Surprisingly, Op-IAP expression in S2 cells enhanced apoptosis caused by baculovirus infection, but did not cause increased sensitivity to either actinomycin D or UV damage-induced apoptosis. (utmb.edu)
- Caenorhabditis elegans protein arginine methyltransferase PRMT-5 negatively regulates DNA damage-induced apoptosis. (omicsdi.org)
- Here we report that the Caenorhabditis elegans homolog of mammalian type II arginine methyltransferase PRMT5 negatively regulates DNA damage-induced apoptosis. (omicsdi.org)
Signal transduction3
- Proteins that contain this domain play a role in APOPTOSIS-related signal transduction by associating with other CARD domain-containing members and in activating INITIATOR CASPASES that contain CARD domains within their N-terminal pro-domain region. (uams.edu)
- 14.3.3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism , protein trafficking, signal transduction , apoptosis and cell cycle regulation. (tocris.com)
- Functions in integrin signal transduction, but also in signaling downstream of numerous growth factor receptors, G-protein coupled receptors (GPCR), EPHA2, netrin receptors and LDL receptors. (idrblab.net)
Peptides1
- This family of proteins includes many ONCOGENE PROTEINS as well as a wide variety of classes of INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS such as CASPASES . (bvsalud.org)
Phosphorylation6
- A pro-apoptotic protein and member of the Bcl-2 protein family that is regulated by PHOSPHORYLATION. (ucdenver.edu)
- 14.3.3 proteins are regulated by post-translational modifications such as phosphorylation, and by the binding of cofactors. (tocris.com)
- Phosphorylation sites on 14.3.3 proteins are not conserved between family members and thus enable selective isoform regulation. (tocris.com)
- Because many 14.3.3 interactions are phosphorylation dependent, 14.3.3 proteins have been integrated into the core regulatory pathways that are crucial for normal growth and development. (tocris.com)
- this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. (idrblab.net)
- The effects of insulin and insulin-like growth factor I on amyloid precursor protein phosphorylation in in vitro and in vivo models of Alzheimer's disease. (shefayekhatam.ir)
Cells36
- Treatment of 7-day differentiated MC3T3-E1 clone-4 (MC-4) mouse osteoblastic cells and primary calvarial osteoblasts with PTH for 30min to 5h followed by Western blot analysis showed 2- to 3-fold down-regulation of CARP-1 protein expression in a dose- and time-dependent manner compared to the respective vehicle treated control cells. (embl-heidelberg.de)
- In addition, expression of Op-IAP was unable to inhibit apoptosis triggered by either actinomycin D or UV light in D. melanogaster S2 cells. (utmb.edu)
- Moreover, futher mechanism analysis demonstrated that 4k caused G2/M arrest, induced cells apoptosis in HeLa cells, and manifested significant tubulin polymerization inhibitory activity with the IC50 value of 4.9 µM, which is comparable to CA-4 (IC50 = 4.2 µM). (bvsalud.org)
- Novel benzylidene-thiazolidine-2,4-diones inhibit Pim protein kinase activity and induce cell cycle arrest in leukemia and prostate cancer cells. (ucdenver.edu)
- The basic role of these proteins is the promotion of proliferation, maturation, and differentiation of haematopoietic stem cells (HSC) with nutrient-rich microenvironment and growth factors. (termedia.pl)
- It is noteworthy that, from ECM proteins, collagens and laminin enhance the proliferation and differentiation of myeloid cells not only in bone marrow but also in the extramedullary localisation [9]. (termedia.pl)
- Regulation of apoptosis and caspase-8 expression in neuroblastoma cells by isoforms of the IG20 gene. (rush.edu)
- CM1 ligation initiates apoptosis in a caspase 8-dependent manner in Ramos cells and in a mitochondria-controlled manner in Raji cells. (rush.edu)
- However the molecular mechanism by which the junctional pool of YAP proteins is released and activated in epithelial cells remains unknown. (ox.ac.uk)
- Here we report that the tumour suppressor ASPP2 forms an apical-lateral polarity complex at the level of tight junctions in polarised epithelial cells, acting as a scaffold for protein phosphatase 1 (PP1) and junctional YAP via dedicated binding domains. (ox.ac.uk)
- 14.3.3 proteins are ubiquitously expressed and self assemble into homo- and heterodimers, with the exception of 14.3.3σ, which exclusively forms homodimers and is found in cells of epithelial origin only. (tocris.com)
- Identification of protease serine S1 family member 53 as a mitochondrial protein in murine islet beta cells, Islets, Vol.14, No.1, 1-13, 2021. (tokushima-u.ac.jp)
- Selenium (Se) is an essential micronutrient that functions as a redox gatekeeper through its incorporation into proteins to alleviate oxidative stress in cells. (mdpi.com)
- Although somatic (developmental) apoptosis was unaffected, ionizing radiation-induced apoptosis of germ cells was obliterated upon inactivation of ceramide synthase and restored upon microinjection of long-chain natural ceramide. (omicsdi.org)
- Apoptosis is an important biological process in the development and stress context by removing unwanted or damaged cells. (plos.org)
- Programmed Cell Death (PCD) or apoptosis plays essential roles both in the development and stress context by removing unwanted or damaged cells to keep the balance [ 1 , 2 ]. (plos.org)
- Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of the apoptosis antagonist SMAC (second mitochondria-derived activator of caspases), exerts synergistic killing of PANC-1 human pancreatic adenocarcinoma cells. (biomedcentral.com)
- To investigate potential mechanisms underlying this synergistic pharmacodynamic interaction, data capturing PANC-1 cell growth, apoptosis kinetics, and cell cycle distribution were integrated with high-quality IonStar-generated proteomic data capturing changes in the relative abundance of more than 3300 proteins as the cells responded to the two drugs, alone and combined. (biomedcentral.com)
- The model, consistent with the observed reduction in the Bcl2/BAX ratio, suggests that BRP-induced apoptosis of mitotically-arrested cells is a major contributor to the synergy between BRP and PTX. (biomedcentral.com)
- Clinical manifestations of the disease, the presence of histiocytic infiltrate in the epidermis and dermis during the histological study and immunohistochemical detection of langerin infiltrate cells and S-100 protein were all consistent with the diagnosis of LCH. (vestnikdv.ru)
- It helps control cell growth and division (proliferation), cell movement (migration), and the self-destruction of cells (apoptosis). (medlineplus.gov)
- In the immune system, the STAT3 protein transmits signals for the maturation of immune system cells, especially T cells and B cells. (medlineplus.gov)
- In the skeletal system, the STAT3 protein is involved in the formation of specialized cells that build and break down bone tissue. (medlineplus.gov)
- A shortage of functioning STAT3 protein prevents cells from reacting to signals that trigger allergic reactions, which explains why people with AD-HIES do not have an increased risk of allergies, despite having high levels of IgE. (medlineplus.gov)
- Aside from its anticoagulant action, heparin binds to various growth factors, cytokines, and extracellular proteins and consequently is able to affect migration of cancer cells and angiogenesis in tumors. (hindawi.com)
- Extremely low frequency magnetic fields regulate differentiation of regulatory T cells: potential role for ROS-mediated inhibition on AKT [med. (emf-portal.org)
- In non-replicating cells, retinocytoma protein (pRB) can bind to gene regulatory protein E2F, thereby inhibiting cell proliferation. (medicaltrend.org)
- Auxin-inducible degrons are a chemical genetic tool for targeted protein degradation and are widely used to study protein function in cultured mammalian cells. (elifesciences.org)
- Data show that BACH2 and STAT5B are activated by viral insertions, generating chimeric mRNAs specifically enriched in T regulatory cells favoring their persistence. (cusabio.com)
- ABL-N administration induced apoptosis of PC3 cells in a dose-dependent manner, along with the enhanced activity of caspases and increased Bax/Bcl-2 ratio. (cusabio.com)
- Background: Galectin-9 is a member of the family of lectin proteins and crucially regulates human immune responses, particularly because of its ability to suppress the anticancer activities of T lymphocytes and natural killer cells. (diamond.ac.uk)
- Spatiotemporal in vivo tracking of polyclonal human regulatory T cells (Tregs) reveals a role for innate immune cells in Treg transplant recruitment. (peprotech.com)
- The objective of this study was to determine whether the increased AKT or MAPK kinase-1/2 (MEK1/2) activity observed in endometriotic stromal cells (OSIS) from ovarian endometriomas influences levels of PR protein. (webpediatrica.com)
- Inhibiting AKT with MK-2206 or MEK1/2 with U0126 for 24 hours in the absence of R5020 increased total and nuclear PRA and PRB protein levels in OSIS but not in eutopic endometrial stromal cells from disease-free patients from disease-free patients. (webpediatrica.com)
- We evaluated receptor mRNA and protein expression levels and effects of octreotide, pasireotide, and cabergoline on ACTH secretion by cultured human corticotroph adenoma cells. (webpediatrica.com)
- PDCD6, a new HL gene, plays an important role in apoptosis and has widespread inner ear expression, particularly in the inner hair cells. (cdc.gov)
Regulation16
- CCAR2) is a protein implicated in the regulation of apoptosis, transcription and histone modifications. (embl-heidelberg.de)
- Like cytokines, the extracellular matrix (ECM) proteins are another group of signalling molecules taking part in complex regulation of haematopoiesis [3]. (termedia.pl)
- Fibronectin, collagens, laminin, thrombospondin, and vitronectin are a group of ECM proteins with lesser known function in haematopoiesis regulation. (termedia.pl)
- To date, H 2 O 2 -dependent signaling has been shown to play a key role in the regulation of many cellular processes including differentiation, proliferation, migration, and apoptosis [ 3 , 7 - 9 ]. (hindawi.com)
- Previous studies demonstrated that quercetin, a polyphenolic compound, inhibits the transport of iron by down-regulation of ferroportin (FPN1), an iron export protein. (bvsalud.org)
- this effect may be associated with regulation of autophagy and apoptosis. (spandidos-publications.com)
- Arginine methylation of histone and non-histone proteins is involved in transcription regulation and many other cellular processes. (omicsdi.org)
- We show that inactivation of C. elegans prmt-5 leads to excessive apoptosis in germline following ionizing irradiation, which is due to a CEP-1/p53-dependent up-regulation of the cell death initiator EGL-1. (omicsdi.org)
- Importantly, down-regulation of cbp-1 significantly suppresses DNA damage-induced egl-1 expression and apoptosis in prmt-5 mutant worms. (omicsdi.org)
- These results indicate that Dmp18 negatively regulates apoptosis by mediating H2Av incorporation and histone H3 modifications at pro-apoptotic gene loci for transcriptional regulation. (plos.org)
- Through its regulation of gene activity, the STAT3 protein is involved in many cellular functions. (medlineplus.gov)
- In addition, the protein is involved in the regulation of inflammation, which is one way the immune system responds to infection or injury, and it plays a role in cellular processes that promote allergic reactions. (medlineplus.gov)
- aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. (umbc.edu)
- Conclusion: p63, p16, MIB, Cal A, Cys A are markedly expressed and p16 is strongly suppressed in oral cavity tumors, which suggests that the latter protein may play a role in negative regulation of cell cycle progression. (bvsalud.org)
- Another protein, calgranulin A (Cal A), is involved in the regulation of several cell processes, including the cell cycle and cell differentiation. (bvsalud.org)
- Interacting with various cellular proteins, E6 and E7 influence fundamental cellular functions like cell cycle regulation, telomere maintenance, susceptibility to apoptosis, intercellular adhesion and regulation of immune responses. (info-tecuci.ro)
Transcription7
- The main cellular antioxidant systems responsible for recycling REDOX sensitive proteins are the thioredoxin (Trx) and glutathione (GSH) systems that reduce active cysteine residues present in ROS scavenging proteins (reestablishing their antioxidant function) and other proteins, whose functions are regulated by the oxidative status of key reactive cysteine residues (e.g., protein tyrosine phosphatases (PTPs), transcription factors, and the phosphatase and tensin homolog, PTEN) (Figure 1 ). (hindawi.com)
- 14.3.3 proteins are phospho-serine/-threonine binding proteins that have a diverse array of partners including transcription factors, biosynthetic enzymes, cytoskeletal proteins , signaling molecules, apoptosis factors and tumor suppressors. (tocris.com)
- HCV core and NS5A proteins appear to be the most important molecules with regulatory functions that modulate transcription, cellular proliferation, and apoptosis. (kegg.jp)
- STAT proteins are called transcription factors on the basis of this action. (medlineplus.gov)
- Adenovirus E2 promoter can be divided into early and late promoters, used to regulate the E2 transcription unit, the late E2 promoter region contains Y-box, the binding site of transcription factor YB-1 (Y-box binding protein-1). (medicaltrend.org)
- Clone REA516 recognizes the human and mouse interferon regulatory factor 8 (IRF-8) antigen, a 50 kDa transcription factor, which is also known as interferon consensus sequence-binding protein (ICSBP). (miltenyibiotec.com)
- IRF-8 belongs to the family of interferon regulatory transcription factors, which consists of nine members in both human and mice and is characterized by a conserved N-terminal DNA-binding domain with a unique tryptophan pentad repeat. (miltenyibiotec.com)
Tumor5
- A number of markedly expressed proteins from GeLC-MS/MS were identified, including the multifunctional tumor necrosis factor receptor superfamily member 18 (TNFRSF18), in DTs at 1-2 and 6 weeks and in UDTs at 15 and 20 weeks of age. (biomedcentral.com)
- We will then make a comprehensive assessment of the current literature regarding the main antioxidant proteins and systems that have been shown to be positively associated with tumor progression and chemoresistance. (hindawi.com)
- Here we found that the apoptosis-stimulating protein of p53 2 (ASPP2), a host tumor suppressor and an important CagA target, contributes to the survival of cagA-positive H. pylori in the lumen of infected gastric organoids. (ox.ac.uk)
- our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein beta-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers. (ewmccall.com)
- The p63 protein, a homologue of p53, may be associated with tumor formation in the epithelial tissue, acting as an oncogene 11,12 . (bvsalud.org)
Role in regulatin1
- Here, we demonstrate that the chromatin remodeler Dmp18, the homolog of mammalian Znhit1, plays a crucial role in regulating apoptosis in eye and wing development. (plos.org)
Inhibition6
- Neuronal apoptosis induced by selective inhibition of Rac GTPase versus global suppression of Rho family GTPases is mediated by alterations in distinct mitogen-activated protein kinase signaling cascades. (ucdenver.edu)
- JQ1/A-1331852 and JQ1/S63845 co-treatment enhanced this pro-apoptotic rebalancing and triggered BAK- and BAX-dependent apoptosis since a) genetic silencing of BIM, BAK or BAX, b) inhibition of caspase activity with zVAD.fmk and c) overexpression of BCL-2 all rescued JQ1/A-1331852- and JQ1/S63845-induced cell death. (prinsesmaximacentrum.nl)
- 14.3.3 proteins are directly involved in cellular processes such as cytokinesis, cell-contact inhibition, anchorage-independent growth and cell adhesion , and it is these pathways that often become dysregulated in disease states such as cancer . (tocris.com)
- Inhibition of apoptosis suppressed the eye defects caused by Dmp18 deletion. (plos.org)
- Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. (proteopedia.org)
- Inhibition of AKT or MEK1/2 increased total and nuclear PR protein in OSIS. (webpediatrica.com)
Highly conserved2
- DBC1 shares many highly conserved protein domains with its paralog cell cycle and apoptosis regulator 1 (CCAR1, CARP-1). (embl-heidelberg.de)
- Programmed Cell Death (PCD) or apoptosis is a highly conserved biological process and plays essential roles both in the development and stress context. (plos.org)
Pathways8
- A better understanding of the interactions of these molecules with other pathways relevant to carcinogenesis could further our understanding of apoptosis and autophagy, and their role in breast carcinogenesis. (bl.uk)
- 14.3.3 proteins represent an integration point for proliferative, survival, apoptotic and stress signaling pathways . (tocris.com)
- This poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate. (tocris.com)
- This generalisable approach provides unprecedented temporal control over the dose of endogenous proteins in mouse models, with implications for studying essential biological pathways and modelling drug activity in mammalian tissues. (elifesciences.org)
- ADP ribosylation factors (ARFs), which are members of the Ras superfamily of GTP-binding proteins, are critical components of vesicular trafficking pathways in eukaryotes. (embl.de)
- Glycogen synthase kinase 3 (GSK3) proteins (GSK3α and GSK3β) are key mediators of signaling pathways, with crucial roles in coordinating fundamental biological processes during neural development. (eneuro.org)
- Glycogen synthase kinase 3 (GSK3) proteins (GSK3α or GSK3β) are key mediators of signaling pathways, especially in the CNS but poorly described in the retina. (eneuro.org)
- One of these methods is the use of intracellular factors in the treatment of stroke, which can control various cellular pathways, such as apoptosis, division, and other pathways. (shefayekhatam.ir)
Cytokines1
- The Cold War: A New History cytokines display from popular and lovely to on-line and regulatory, but what remains them not appears their Purchase to have, protect, induce, Sign, choose, Join, and use findings. (michael-noeres.de)
Anti-apoptotic proteins1
- ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis. (prinsesmaximacentrum.nl)
Cellular4
- The cellular REDOX regulatory systems play a central role in maintaining REDOX homeostasis that is crucial for cell integrity, survival, and proliferation. (hindawi.com)
- Nanosecond pulsed electric fields activate AMP-activated protein kinase: implications for calcium-mediated activation of cellular signaling [med. (emf-portal.org)
- Kinases can cause posttranslational modifications of the progesterone receptor (PR) to influence cellular localization and protein stability. (webpediatrica.com)
- Ischemic stroke is followed by a series of events, such as inflammation, increased oxidative stress, and the spread of damage, that can lead to mitochondrial damage, protein degradation, and cellular apoptosis. (shefayekhatam.ir)
Oxidative1
- Workplace exposures equivalent to no or low observable proteins and other molecular chaperones (valosin-containing pro- adverse effect concentrations in animals: Step by step tein or VCP) are up-regulated to handle the increase of misfolded approach and damaged proteins which are causing oxidative stress. (cdc.gov)
Onset of apoptosis1
- Changes in the levels of cell regulatory proteins were observed thereafter, in particular, Chk2 was activated upon DNA cleavage initiated by the foregoing onset of apoptosis,and this correlated with the S phase cell arrest after 24 hours. (univie.ac.at)
Proliferation and apoptosis1
- Non-receptor protein-tyrosine kinase that plays an essential role in regulating cell migration, adhesion, spreading, reorganization of the actin cytoskeleton, formation and disassembly of focal adhesions and cell protrusions, cell cycle progression, cell proliferation and apoptosis. (idrblab.net)
Regulator2
- A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. (ouhsc.edu)
- Several NSAIDs indeed trigger increases in mobile [Ca2+] and oxidant tension (Tanaka research with cultured enterocytes, where high concentrations of diclofenac could actually trigger cyclosporin ACsensitive adjustments in calcein/Co2+ fluorescence, a recognized indicator from the mPT (LoGuidice by focusing on cyclophilin D (CypD), a mitochondrial matrix proteins and important regulator from the mPT. (cancerhugs.com)
Mitochondrial-apoptosis1
- In summary, JQ1/A-1331852 and JQ1/S63845 co-treatment represent new promising therapeutic strategies to synergistically trigger mitochondrial apoptosis in RMS. (prinsesmaximacentrum.nl)
Suppresses2
- S-nitrosylation of Bcl-2 inhibits its ubiquitin-proteasomal degradation - a novel antiapoptotic mechanism that suppresses apoptosis. (cdc.gov)
- Parathyroid hormone (PTH) controls osteoblast cell cycle regulatory proteins and suppresses mature osteoblasts apoptosis. (embl-heidelberg.de)
Degradation4
- P104-012 stopped protein degradation. (cdc.gov)
- Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. (ewmccall.com)
- Here we develop CRISPR-engineered mouse lines that enable rapid and highly specific degradation of tagged endogenous proteins in vivo . (elifesciences.org)
- By combining ligand titrations with genetic crosses to generate animals with different allelic combinations, we show that degradation kinetics depend upon the dose of the tagged protein, ligand, and the E3 ligase substrate receptor TIR1. (elifesciences.org)
Epigenetic3
- Deleted in breast cancer 1 (DBC1, CCAR2, KIAA1967) is a large, predominantly nuclear, multidomain protein that modulates gene expression by inhibiting several epigenetic modifiers, including the deacetylases SIRT1 and HDAC3, and the methyltransferase SUV39H1. (embl-heidelberg.de)
- Recent research has also demonstrated an involvement of 14.3.3 proteins as 'reader' domains of epigenetic marks. (tocris.com)
- Our study uncovers the role of Dmp18 in regulating apoptosis in Drosophila eye and wing development and provides insights into chromatin remodeling regulating apoptosis at the epigenetic levels. (plos.org)
Caspase-dependent2
- and immunoblot analysis to determine the levels of cleaved poly-ADP ribose polymerase (PARP) and lamin A that result from caspase-dependent apoptosis. (springernature.com)
- EGL-1 and CED-13 proteins inactivate Bcl-2 like CED-9 to trigger CED-4 and CED-3 caspase dependent germ cell apoptosis. (omicsdi.org)
Molecules1
- Furthermore, we established knocked-down sub-lines of MCF7 and MDA-MB-231, in which we studied the effects of knock-down of DAP1 and DAP3 on cell growth, adhesion, migration and invasion, as well as the expression of molecules related to apoptosis (caspase 8, caspase 9, IPS1 and DELE) and the cell cycle (p21WAF1 and cyclin Dl). (bl.uk)
Regulates1
- Together, this study reveals the mechanism by which Dmp18 regulates apoptosis in the eye and wing discs. (plos.org)
Caspases4
- Since some IAP proteins can bind and inhibit caspases, we tested whether Op-IAP could inhibit the activity of caspases from Drosophila melanogaster. (utmb.edu)
- We found that recombinant Op-IAP protein was not able to bind or directly inhibit the activity of the Drosophila caspases DRONC, DrICE, or DCP-1 in vitro. (utmb.edu)
- Caspase 8 plays a role in APOPTOSIS by cleaving and activating EFFECTOR CASPASES. (rush.edu)
- CASP3_HUMAN ] Involved in the activation cascade of caspases responsible for apoptosis execution. (proteopedia.org)
Kinase6
- Small molecule inhibitors of the dual-specificity protein kinase MEK1, MEK1 siRNA, Bim siRNA, and vectors overexpressing MEK1 wild type and mutant, dominant negative cDNA were used to identify key IGF-1 downstream prosurvival effectors.ResultsIGF-1, at physiologically relevant levels, blocked the cytotoxic action(s) of the antiestrogens 4-hydroxytamoxifen (4-OHT) and tamoxifen (TAM) when used as single agents or in combination with the antiprogestin MIF. (springernature.com)
- Several derivatives of 5-aminoimidazole-4-carboxamide-1--d-ribofuranoside (AICAR), an AMP-activated protein kinase (AMPK) activator, were identified as transcriptional activators of the DDT gene. (tokushima-u.ac.jp)
- Catalytic domain of the Protein Serine/Threonine Kinase, Atypical Protein Kinase C. Serine/Threonine Kinases (STKs), Atypical Protein Kinase C (aPKC) subfamily, catalytic (c) domain. (umbc.edu)
- The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
- Anaplastic lymphoma kinase (ALK) protein may be detected in most cases (60-70%) of systemic ALCL by immunohistochemistry. (medscape.com)
- PAPbeta, a protein that binds to and is phosphorylated by the non-receptor tyrosine kinase PYK2, contains several modular signaling domains including a pleckstrin homology domain, an SH3 domain, ankyrin repeats and an ARF-GAP domain. (embl.de)
Amino Acids2
- Most of the mutations involved in this condition change single amino acids in the STAT3 protein. (medlineplus.gov)
- They change single protein building blocks (amino acids) in the STAT3 protein, resulting in an altered protein that is abnormally active. (medlineplus.gov)
Mechanism6
- However, the mechanism by which Op-IAP inhibits apoptosis is unclear. (utmb.edu)
- One mechanism whereby these defects occur is a disruption of normal apoptosis in the brain. (biologists.com)
- The present study revealed the specific PMFs and clusters for porcine cryptorchidism, and a novel protein, TNFRSF18, associated with the disease mechanism. (biomedcentral.com)
- The expression of protein markers could possibly be utilized not only for unveiling the aberrant mechanism underlying the disease, but also for selection of suitable sires from the GGPs and GPs, which might reduce the incidence of cryptorchidism in fattening pigs. (biomedcentral.com)
- These findings suggest that PRMT-5 likely represses CEP-1 transcriptional activity through CBP-1, which represents a novel regulatory mechanism of p53-dependent apoptosis. (omicsdi.org)
- A multi-scale, mechanism-based mathematical model was developed to investigate integrated birinapant/paclitaxel effects on temporal profiles of key proteins involved in kinetics of cell growth, death, and cell cycle distribution. (biomedcentral.com)
Autophagy1
- Background: Death-associated protein 1 (DAP1) has recently been implicated in the control of autophagy. (bl.uk)
MRNA6
- Further, quercetin down-regulated the protein and mRNA expression of HEPH and FPN1 but not that of IRP2 or DMT1. (bvsalud.org)
- After invasion, HCV RNA genome functions directly as an mRNA in the cytoplasm of the host cell and forms membrane-associated replication complexes along with non-structural proteins. (kegg.jp)
- Overexpression or deregulation of E2F-1 increased the expression levels of ASPP1 and ASPP2 mRNA and proteins. (ox.ac.uk)
- There were no statistically significant differences in sst 5 and D 2 R mRNA expression or in sst 2 , sst 5 , and D 2 R protein expression between both groups of corticotroph adenomas. (webpediatrica.com)
- After achieving normocortisolism induced by medical therapy, cortisol-mediated sst 2 downregulation on corticotroph adenomas appears to be a reversible process at the mRNA but not at the protein level. (webpediatrica.com)
- Real-time PCR and Western blotting were used to assess mRNA and protein expression of cartonectin. (webpediatrica.com)
Differentiation2
- Cell Cycle and Apoptosis Regulatory Protein (CARP)-1 (aka CCAR1) is a novel transducer of signaling by diverse agents including cell growth and differentiation factors. (embl-heidelberg.de)
- Retinoic DAPK Substrate Peptide acidity, a ligand for RAR can be an analogue of supplement A (retinol) that has important function in legislation of growth, apoptosis and DAPK Substrate Peptide differentiation. (euromed2016.com)
Bcl21
- Whereas BRP or PTX alone produced no change in the pro-apoptotic protein pJNK, and a slight increase in the anti-apoptotic protein Bcl2, the drug combination increased pJNK and decreased Bcl2 significantly compared to the vehicle control. (biomedcentral.com)
Peptide1
- Hence, we decided to explore a panel of novel peptide and protein expression, using proteomic approaches. (biomedcentral.com)
Assay Kit1
- The CycLex Cdc25A Combo Fluorometric Assay Kit is a fluorometric and non-radioactive assay designed to measure the activity of Cdc25A protein phosphatase. (mblintl.com)
Apoptotic3
- Mechanistic studies revealed that JQ1 upregulated BIM and NOXA accompanied by downregulation of BCL-xL, promoting pro-apoptotic rebalancing of BCL-2 proteins. (prinsesmaximacentrum.nl)
- Thus, understanding the regulatory mechanisms of apoptotic process can provide insights into disease treatment and prevention [ 3 , 6 , 7 ]. (plos.org)
- The anti proliferative properties of the C. morifolia petroleum ether extract turned out to be attributable to the induction of cell death as the apoptotic executioner protein caspase 3 was already activated within 2 hours of incubation. (univie.ac.at)
Recombinant1
- Recombinant Murine IFN- λ2 is a 19.8 kDa protein containing 175 amino acid residues. (peprotech.com)
Scaffold1
- In addition, 14.3.3 proteins can act as a scaffold molecule to anchor target proteins within close proximity of one another. (tocris.com)
MeSH1
- bcl-Associated Death Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
Activation4
- Radiation-induced increase in the concentration of ceramide localized to mitochondria and was required for BH3-domain protein EGL-1-mediated displacement of CED-4 (an APAF-1-like protein) from the CED-9 (a Bcl-2 family member)/CED-4 complex, an obligate step in activation of the CED-3 caspase. (omicsdi.org)
- Apoptosis can be driven by either activating Bax or by activation of MST kinases. (ox.ac.uk)
- PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. (umbc.edu)
- Promotes localized and transient activation of guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs), and thereby modulates the activity of Rho family GTPases. (idrblab.net)
Mutations2
- Most of these mutations have a dominant-negative effect, which means that the altered protein produced from one copy of the STAT3 gene interferes with the function of the normal protein produced from the other copy of the gene. (medlineplus.gov)
- The role of STAT3 protein in the formation and maintenance of bone tissue may help explain why STAT3 gene mutations lead to the skeletal and dental abnormalities characteristic of this condition, but it is unclear what causes blood vessel abnormalities in AD-HIES. (medlineplus.gov)