Apomorphine
Receptors, Dopamine
Haloperidol
A phenyl-piperidinyl-butyrophenone that is used primarily to treat SCHIZOPHRENIA and other PSYCHOSES. It is also used in schizoaffective disorder, DELUSIONAL DISORDERS, ballism, and TOURETTE SYNDROME (a drug of choice) and occasionally as adjunctive therapy in INTELLECTUAL DISABILITY and the chorea of HUNTINGTON DISEASE. It is a potent antiemetic and is used in the treatment of intractable HICCUPS. (From AMA Drug Evaluations Annual, 1994, p279)
Piribedil
Emetics
Penile Erection
Pimozide
A diphenylbutylpiperidine that is effective as an antipsychotic agent and as an alternative to HALOPERIDOL for the suppression of vocal and motor tics in patients with Tourette syndrome. Although the precise mechanism of action is unknown, blockade of postsynaptic dopamine receptors has been postulated. (From AMA Drug Evaluations Annual, 1994, p403)
Stereotyped Behavior
Dopamine Antagonists
Drugs that bind to but do not activate DOPAMINE RECEPTORS, thereby blocking the actions of dopamine or exogenous agonists. Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. Dopamine antagonists have been used for several other clinical purposes including as ANTIEMETICS, in the treatment of Tourette syndrome, and for hiccup. Dopamine receptor blockade is associated with NEUROLEPTIC MALIGNANT SYNDROME.
Startle Reaction
Levodopa
The naturally occurring form of DIHYDROXYPHENYLALANINE and the immediate precursor of DOPAMINE. Unlike dopamine itself, it can be taken orally and crosses the blood-brain barrier. It is rapidly taken up by dopaminergic neurons and converted to DOPAMINE. It is used for the treatment of PARKINSONIAN DISORDERS and is usually given with agents that inhibit its conversion to dopamine outside of the central nervous system.
Antiparkinson Agents
Dopamine
One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.
Receptors, Dopamine D2
Catalepsy
A condition characterized by inactivity, decreased responsiveness to stimuli, and a tendency to maintain an immobile posture. The limbs tend to remain in whatever position they are placed (waxy flexibility). Catalepsy may be associated with PSYCHOTIC DISORDERS (e.g., SCHIZOPHRENIA, CATATONIC), nervous system drug toxicity, and other conditions.
Tranquilizing Agents
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
Carbidopa
Sensory Gating
Yawning
Parkinson Disease
A progressive, degenerative neurologic disease characterized by a TREMOR that is maximal at rest, retropulsion (i.e. a tendency to fall backwards), rigidity, stooped posture, slowness of voluntary movements, and a masklike facial expression. Pathologic features include loss of melanin containing neurons in the substantia nigra and other pigmented nuclei of the brainstem. LEWY BODIES are present in the substantia nigra and locus coeruleus but may also be found in a related condition (LEWY BODY DISEASE, DIFFUSE) characterized by dementia in combination with varying degrees of parkinsonism. (Adams et al., Principles of Neurology, 6th ed, p1059, pp1067-75)
Dopamine Agents
Parkinson Disease, Secondary
Conditions which feature clinical manifestations resembling primary Parkinson disease that are caused by a known or suspected condition. Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and masked facies. In general, tremor is less prominent in secondary parkinsonism than in the primary form. (From Joynt, Clinical Neurology, 1998, Ch38, pp39-42)
Domperidone
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Receptors, Dopamine D1
Oxidopamine
Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide
Amphetamine
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
Harmine
Alkaloid isolated from seeds of Peganum harmala L., Zygophyllaceae. It is identical to banisterine, or telepathine, from Banisteria caapi and is one of the active ingredients of hallucinogenic drinks made in the western Amazon region from related plants. It has no therapeutic use, but (as banisterine) was hailed as a cure for postencephalitic Parkinson disease in the 1920's.
Substantia Nigra
Corpus Striatum
Striped GRAY MATTER and WHITE MATTER consisting of the NEOSTRIATUM and paleostriatum (GLOBUS PALLIDUS). It is located in front of and lateral to the THALAMUS in each cerebral hemisphere. The gray substance is made up of the CAUDATE NUCLEUS and the lentiform nucleus (the latter consisting of the GLOBUS PALLIDUS and PUTAMEN). The WHITE MATTER is the INTERNAL CAPSULE.
Penis
The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.
Receptors, Dopamine D3
Infusion Pumps
Fluid propulsion systems driven mechanically, electrically, or osmotically that are used to inject (or infuse) over time agents into a patient or experimental animal; used routinely in hospitals to maintain a patent intravenous line, to administer antineoplastic agents and other drugs in thromboembolism, heart disease, diabetes mellitus (INSULIN INFUSION SYSTEMS is also available), and other disorders.
Dyskinesia, Drug-Induced
Abnormal movements, including HYPERKINESIS; HYPOKINESIA; TREMOR; and DYSTONIA, associated with the use of certain medications or drugs. Muscles of the face, trunk, neck, and extremities are most commonly affected. Tardive dyskinesia refers to abnormal hyperkinetic movements of the muscles of the face, tongue, and neck associated with the use of neuroleptic agents (see ANTIPSYCHOTIC AGENTS). (Adams et al., Principles of Neurology, 6th ed, p1199)
Sulpiride
Spiperone
Erectile Dysfunction
Lisuride
Injections, Subcutaneous
Flupenthixol
Dose-Response Relationship, Drug
Modifications of local cerebral metabolic rates for glucose and motor behavior in rats with unilateral lesion of the subthalamic nucleus. (1/551)
Inactivation of the subthalamic nucleus (STN) has attracted interest as a therapeutic tool in Parkinson's disease. The functional consequences of the inactivation, however, are uncertain. In this study definition of the pattern of changes of cerebral functional activity associated with lesion of the STN and dopaminergic stimulation, by using the [14C]deoxyglucose method, was sought. Six or 7 days following unilateral lesion of the STN, the animals were divided into two groups: One group (n = 10) was administered apomorphine (1 mg/kg) subcutaneously; the second group (n = 10) received saline. The [14C]deoxyglucose procedure was initiated 10 minutes following the drug or saline injection. The results show that systemic administration of apomorphine to rats with unilateral lesion of the STN causes ipsiversive rotational behavior and asymmetries of glucose utilization of defined brain areas, including the substantia nigra reticulata, globus pallidus, and entopeduncular nucleus. These nuclei are the main targets of the subthalamic excitatory projections. Lesion of the nucleus per se (without challenge with apomorphine) has no significant consequences on glucose utilization. The findings indicate that the STN is involved in the activation of the basal ganglia output nuclei induced by systemic dopaminergic stimulation. (+info)Effects of tetrahydroprotoberberines on dopamine D2 receptors in ventral tegmental area of rat. (2/551)
AIM: To compare the actions of tetrahydroprotoberberines (THPB) on dopamine (DA) D2 receptors in the ventral tegmental area (VTA) of rat. METHODS: Extracellular single unit recording technique was used in i.v. gallamine-paralyzed rats. RESULTS: Eleven THPB analogs tested completely attenuated the apomorphine (Apo, 20 micrograms.kg-1)-induced inhibition on VTA DA cell firing activity. The OH group on C2 at THPB was linked with the reversal of Apo-induced inhibition. Their reversal potencies (ED50, microgram.kg-1) for D2 receptors were: THPB-143 (5.6) > SPD (8.5) > Iso (17.0) > THP (33) > THB (48) > THPB-18 (66) > THPB-1 (179) > THPB-19 (408) > THPB-126 (510) > THPB-104 (1019) > THPB-10 (4815). CONCLUSION: Among these 11 THPB, the 2-hydroxyl-THPB (THPB-143) showed the strongest antagonistic action on D2 receptors. (+info)Comparison of effects of haloperidol administration on amphetamine-stimulated dopamine release in the rat medial prefrontal cortex and dorsal striatum. (3/551)
Research has shown that there are important neurochemical differences between the mesocortical and mesostriatal dopamine systems. The work reported in this paper has sought to compare the regulation of dopamine release in the medial prefrontal cortex and the anterior caudate-putamen. In vivo microdialysis was used to recover dialysate fluid for subsequent assay for dopamine concentrations. The responses to D2 antagonist (haloperidol) administration, which has been shown to increase impulse-dependent dopamine release, were compared. Results demonstrated a diminished effect of systemic haloperidol administration on dopamine efflux in the prefrontal cortex. The responses to systemic administration of a nonimpulse-dependent, transporter-mediated, dopamine releaser (d-amphetamine) were also contrasted. Results again demonstrated a diminished pharmacological effect in the cortex. The potential interaction of stimulation of these two types of dopamine release was examined by coadministration of these compounds. Haloperidol pretreatment dramatically potentiated the dopamine-releasing effect of amphetamine administration. This effect was observed in both the cortex and the striatum. Subsequent work demonstrated that this effect of haloperidol was mediated by D2-like receptors in the prefrontal cortex. These results are discussed in relation to other neurochemical and neuroanatomical studies demonstrating sparse densities of dopamine transporter sites and dopamine D2 receptors in the cortex compared with the striatum. They demonstrate a functional correlate to the recently reported, largely extrasynaptic localization of dopamine transporter sites in the prefrontal cortex. Furthermore, they demonstrate the existence of cortical D2-like autoreceptors that may normally be "silent" under basal conditions. (+info)Multisecond oscillations in firing rate in the basal ganglia: robust modulation by dopamine receptor activation and anesthesia. (4/551)
Multisecond oscillations in firing rate in the basal ganglia: robust modulation by dopamine receptor activation and anesthesia. Studies of CNS electrophysiology have suggested an important role for oscillatory neuronal activity in sensory perception, sensorimotor integration, and movement timing. In extracellular single-unit recording studies in awake, immobilized rats, we have found that many tonically active neurons in the entopeduncular nucleus (n = 15), globus pallidus (n = 31), and substantia nigra pars reticulata (n = 31) have slow oscillations in firing rate in the seconds-to-minutes range. Basal oscillation amplitude ranged up to +/-50% of the mean firing rate. Spectral analysis was performed on spike trains to determine whether these multisecond oscillations were significantly periodic. Significant activity in power spectra (in the 2- to 60-s range of periods) from basal spike trains was found for 56% of neurons in these three nuclei. Spectral peaks corresponded to oscillations with mean periods of approximately 30 s in each nucleus. Multisecond baseline oscillations were also found in 21% of substantia nigra dopaminergic neurons. The dopamine agonist apomorphine (0.32 mg/kg iv, n = 10-15) profoundly affected multisecond oscillations, increasing oscillatory frequency (means of spectral peak periods were reduced to approximately 15 s) and increasing the regularity of the oscillations. Apomorphine effects on oscillations in firing rate were more consistent from unit to unit than were its effects on mean firing rates in the entopeduncular nucleus and substantia nigra. Apomorphine modulation of multisecond periodic oscillations was reversed by either D1 or D2 antagonists and was mimicked by the combination of selective D1 (SKF 81297) and D2 (quinpirole) agonists. Seventeen percent of neurons had additional baseline periodic activity in a faster range (0.4-2.0 s) related to ventilation. Multisecond periodicities were rarely found in neurons in anesthetized rats (n = 29), suggesting that this phenomenon is sensitive to overall reductions in central activity. The data demonstrate significant structure in basal ganglia neuron spiking activity at unexpectedly long time scales, as well as a novel effect of dopamine on firing pattern in this slow temporal domain. The modulation of multisecond periodicities in firing rate by dopaminergic agonists suggests the involvement of these patterns in behaviors and cognitive processes that are affected by dopamine. Periodic firing rate oscillations in basal ganglia output nuclei should strongly affect the firing patterns of target neurons and are likely involved in coordinating neural activity responsible for motor sequences. Modulation of slow, periodic oscillations in firing rate may be an important mechanism by which dopamine influences motor and cognitive processes in normal and dysfunctional states. (+info)Disruption of latent inhibition in rats with postnatal hippocampal lesions. (5/551)
Disruption of latent inhibition has been proposed as a possible model of cognitive abnormalities that underlie positive symptoms of a schizophrenia. We tested neonatal hippocampal lesioned rats in a latent inhibition paradigm. Lesions of the ventral hippocampus were induced by bilateral injections of ibotenic acid in 7 days old rats. The behavior of lesioned rats was tested postpubertally. We found a hyperresponsiveness to dopaminergic stimulation by apomorphine in locomotion tests. Latent inhibition was tested using the acquisition of a conditioned reaction in a two-way shuttle box. Sham operated control animals showed after preexposure of the to-be-conditioned stimulus (combined tone and light stimulus) a low acquisition. Ibotenic acid lesioned animals learned the conditioned reaction with and without preexposure in the same way, indicating disturbed latent inhibition. These results demonstrate disturbances in early postnatal hippocampal lesioned rats comparable with those seen in schizophrenic patients, thus further validating this procedure as a useful animal model of some aspects of schizophrenia. (+info)Rat strain differences in the ability to disrupt sensorimotor gating are limited to the dopaminergic system, specific to prepulse inhibition, and unrelated to changes in startle amplitude or nucleus accumbens dopamine receptor sensitivity. (6/551)
Previous studies indicate that a variety of pharmacological agents interfere with the prepulse inhibition of the acoustic startle (PPI) response including phencyclidine (PCP), 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), amphetamine, and apomorphine. Strain differences have been observed in the ability of apomorphine to disrupt PPI, although the degree to which these strain differences occur after administration of nondopaminergic drugs or the degree to which differences can be observed in other models of dopamine (DA) receptor activation has not been elucidated. The present study tested the effects of apomorphine, amphetamine, 8-OH-DPAT, and PCP on PPI in the Sprague Dawley and Wistar rat strains. Because apomorphine disrupts PPI via activation of DA receptors in the nucleus accumbens, apomorphine-induced hyperlocomotion, also a behavioral model of nucleus accumbens DA receptor activation, was measured in both rat strains. Administration of PCP or 8-OH-DPAT attenuated PPI in both strains, whereas apomorphine and amphetamine only attenuated PPI in Wistar rats. The ability of apomorphine to increase motor activity in the absence of a startle-eliciting stimulus was similar in the two strains, as was apomorphine-induced hyperlocomotion. A time course analysis of the effects of apomorphine on startle response in Sprague Dawley rats found that changes in the magnitude of PPI followed changes in basic startle amplitude. Similarly, no apomorphine-induced attenuation of PPI was observed in Sprague Dawley rats after 6-OHDA-induced DA receptor supersensitivity in the nucleus accumbens. These data suggest a dissociation between the effects of DA receptor agonists in PPI and other behavioral models of DA receptor activation. (+info)Effects of sustained phencyclidine exposure on sensorimotor gating of startle in rats. (7/551)
Phencyclidine (PCP), a non-competitive NMDA antagonist with actions at multiple other central nervous system receptors, can cause both acute and lasting psychoses in humans, and has also been used in cross-species models of psychosis. Acute exposure to PCP in rats produces behavioral changes, including a loss of prepulse inhibition (PPI) of the startle reflex, which parallels the loss of PPI observed in schizophrenia patients. Sustained exposure to PCP in rats produces neuropathological changes in several limbic regions and prolonged behavioral abnormalities that may parallel neuropsychological deficits in schizophrenia. It is unclear whether sustained PCP exposure will also produce a loss of prepulse inhibition which parallels the decrease observed in schizophrenia patients. In the present study, we examined changes in PPI during and after sustained PCP administration, using 5-day PCP exposure via subcutaneous osmotic minipumps, or 14-day PCP exposure via repeated intraperitoneal injections. In both forms of drug delivery, PPI was disrupted during, but not after, sustained drug exposure. PPI does not appear to be sensitive to neuropathological effects of sustained PCP exposure. (+info)Altered activity of midbrain dopamine neurons following 7-day withdrawal from chronic cocaine abuse is normalized by D2 receptor stimulation during the early withdrawal phase. (8/551)
Using in vivo single-unit recording in rats, we compared the effects of continuous cocaine infusion via minipump or single daily injections (both 40 mg/kg/d x 14 days, S.C.) on the activity of putative dopamine (DA) neurons in the substantia nigra pars compacta (SNC) and ventral tegmental area (VTA). On days 1-5 after cocaine withdrawal, animals were further treated with single daily injections of DA agonists. On withdrawal day 7 continuous cocaine caused a reduction in spontaneously active neurons in the SNC and reduced bursting in the VTA. In contrast, intermittent cocaine resulted in an increase in the number of active neurons in the VTA. These changes were all reversed by apomorphine or quinpirole given during the first 5 withdrawal days. The D1 antagonist SCH 39166 did not antagonize the effects of apomorphine in either region. The role of D2 receptors in modulating baseline DA activity during intermediate cocaine withdrawal is discussed. (+info)Apomorphine induced stereotypy - Buy cheap apomorphine
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Comparison of automated home-cage monitoring systems: Emphasis on feeding behaviour, activity and spatial learning following...
Motor response to apomorphine and levodopa in asymmetric Parkinsons disease
FDA Accepts New Drug Application for Sublingual Apomorphine to Treat Motor Fluctuations - Practical Neurology
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List of dopaminergic drugs
Apomorphine • Aripiprazole • Azodopa • Bifeprunox • BP-897 • CY-208,243 • Dizocilpine • Etilevodopa • Flibanserin • Ketamine • ...
Am Spiegelgrund clinic
... spinal injections of apomorphine; injections of phenobarbital; overdoses of sedatives, which would often lead to death when the ...
Dopamine agonist
Apomorphine has a catechol element and belongs to a class called β-phenylethylamines and its main components are similar to the ... The effect that apomorphine has on the dopamine receptors can also be linked to the similarities between its structure and ... When apomorphine interacts with the dopamine receptor, or the ATP on the receptor, the catechol and nitrogen are important to ... Apomorphine had limited use since it had considerable side effects and difficulty with administration. In 1974 bromocriptine ...
Aporphine alkaloids
Apomorphine lowers blood pressure and is also a powerful emetic. It has been used to treat symptoms of Parkinson's disease ... For example, as the name suggests, morphine can be used to produce apomorphine. This can be done by adding an acid under the ... The best known representative is apomorphine. The aporphine alkaloids are of interest mainly because of their similarity to ... Apoglaziovine Apomorphine Bulbocapnine Corydine Glaucine Isoboldine Isothebaine Nuciferine The aporphine alkaloids differ in ...
Nuciferine
It is structurally related to apomorphine. Nuciferine has been reported to have various anti-inflammatory possibly via PPAR ... Apomorphine Aporphine Glaucine Bulbocapnine Nantenine Pukateine Stepholidine Tetrahydropalmatine Bhattacharya, S. K.; Bose, R ...
Aporphine
Studies on subcutaneous apomorphine injection are the closest thing as apomorphine is the bioactive form of aporphine. In a 5- ... The psychoactive effect of the flower is due to two aporphine alkaloids; apomorphine and nuciferine. Apomorphine is known to ... However, apomorphine is used in veterinary clinics as an emetic, due to severe off-target effects that lead to vomiting. In ... Historically, apomorphine has been tried for a variety of uses, including as a way to relieve anxiety and craving in alcoholics ...
Dopamine receptor D1
These include apomorphine, pergolide, rotigotine, and terguride. All of these drugs are preferentially D2-like receptor ...
Domperidone
3-. ISBN 978-1-4831-5550-0. Corsini GU (2010). "Apomorphine: from experimental tool to therapeutic aid" (PDF). In Ban TA, Healy ...
Amyloid beta
Anti-aggregation agents such as apomorphine, or carbenoxolone. The latter has commonly been used as a treatment for peptic ...
Donald Cumming Wilson
They specialised in painkillers: Morphine, Apomorphine and Diamorphine. They also made surgical dressings. During the First ...
Ray Kennedy
His condition improved when he began injections of apomorphine. He was reliant on the Professional Footballers' Association to ...
Biochemistry of Alzheimer's disease
For example, apomorphine was seen to significantly improve memory function through the increased successful completion of the ... February 2011). "Apomorphine treatment in Alzheimer mice promoting amyloid-β degradation". Annals of Neurology. 69 (2): 248-56 ...
LGBT rights in Australia
The patients were subjected to apomorphine injections and electric shocks. At the time, conversion therapy was supported by ...
Nymphaea nouchali var. caerulea
Apomorphine is said to be main psychoactive compound present[inconsistent]. Other compounds include nuciferine. In Southern ... not to be confused with apomorphine, a metabolic product of aporphine). Nymphaea spectabilis, a purple form known from ...
Metoclopramide
Justin-Besancon L, Laville C (1964). "[Antiemetic Action of Metoclopramide with Respect to Apomorphine and Hydergine]". Comptes ...
Erich Harnack
He is remembered for his pharmacological studies of physostigmine and apomorphine. He was the son of theologian Theodosius ... and a short history of apomorphine". Eur Neurol. 69 (6): 321-4. doi:10.1159/000346762. PMID 23549143. Harnack, Gottfried Rudolf ...
Subcutaneous administration
This includes medications such as apomorphine and hyaluronic acid injected as a filler, which may cause the area to appear ... Müller T (October 2020). "An evaluation of subcutaneous apomorphine for the treatment of Parkinson's disease". Expert Opinion ...
Dopamine receptor D3
Oliveira V, Videira G, Mendes A (July 2020). "Loss of Awareness after Continuous Apomorphine Infusion Withdrawal in Parkinson's ... Apomorphine (non-selective dopamine agonist) Bromocriptine (non-selective dopamine agonist) Captodiame CJ-1639 compound R,R-16 ... display antidepressant effects in rodent models of depression.Apomorphine has the ability to help PD patients with their ...
Propylnorapomorphine
Apomorphine "(6aS)-6-Propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline-10,11-diol". ChemSpider. Retrieved 16 January 2016. ... N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine. In rodents it has ... Menon MK, Clark WG, Neumeyer JL (November 1978). "Comparison of the dopaminergic effects of apomorphine and (−)-N-n- ... Riffee WH, Wilcox RE, Smith RV (March 1979). "Stereotypic and hypothermic effects of apomorphine and N-n-propylnorapomorphine ...
Pecazine
Lassen JB (April 1976). "Inhibition and potentiation of apomorphine-induced hypermotility in rats by neuroleptics". Eur. J. ...
Sonepiprazole
However, it does reverse the prepulse inhibition deficits induced by apomorphine, and has also been shown to enhance cortical ... Mansbach RS, Brooks EW, Sanner MA, Zorn SH (January 1998). "Selective dopamine D4 receptor antagonists reverse apomorphine- ... sonepiprazole does not block the behavioral effects of amphetamine or apomorphine, does not alter spontaneous locomotor ...
Management of Parkinson's disease
Apomorphine is also available in a more acute dose as an autoinjector pen for emergency doses such as after a fall or first ... Apomorphine, which is a dopamine agonist not orally administered, may be used to reduce off periods and dyskinesia in late PD. ... Apomorphine can be administered by subcutaneous injection using a small pump which is carried by the patient. A low dose is ... After an initial "apomorphine challenge" in hospital to test its effectiveness and brief patient and primary caregiver (often a ...
Parkinson's disease
Apomorphine, a dopamine agonist, may be used to reduce off periods and dyskinesia in late PD. It is administered only by ... Since secondary effects such as confusion and hallucinations are common, individuals receiving apomorphine treatment should be ... Dopamine agonists include bromocriptine, pergolide, pramipexole, ropinirole, piribedil, cabergoline, apomorphine, and lisuride ... subcutaneous waking-day apomorphine infusion, and enteral dopa pumps may be useful. Late-stage PD presents many challenges ...
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Apomorphine may be used however its use is supported by little evidence. Benzodiazepines may be used to control agitation. ...
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... and the Mechanism of the Morphine-Apomorphine Transformation1". Journal of Organic Chemistry. 5 (4): 334-349. doi:10.1021/ ...
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Apomorphine Bulbocapnine Glaucine Nuciferine Pukateine Tetrahydropalmatine Natesan S, Reckless GE, Barlow KB, et al. (August ...
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Strychnine, alcohol, apomorphine, willow bark, ammonia, and atropine were claimed to have been identified in the injections. ... Strychnine, alcohol, apomorphine, willow bark, ammonia, and atropine were among the many suggested chemicals. The Keeley ...
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1895). "Cholinergic effects of molecular segments of apomorphine and dopaminergic effects of N,N-dialkylated dopamines." J. Med ... phenethylamines and apomorphine." J. Pharmacol. Exp. Ther. 163 188-197. M. Ilhan, J. P. Long and J. G. Cannon (1975). " ...
Apomorphine Sublingual: MedlinePlus Drug Information
Apomorphine Sublingual: learn about side effects, dosage, special precautions, and more on MedlinePlus ... Apomorphine comes as a sublingual film to take under the tongue. Apomorphine sublingual is usually used when needed, according ... Before using apomorphine,. *tell your doctor and pharmacist if you are allergic to apomorphine, any other medications, sulfites ... you should not drink alcohol while you are using apomorphine. Alcohol can make the side effects from apomorphine worse. ...
Sublingual Apomorphine Alleviates Parkinson's OFF Episodes
A new sublingual apomorphine film rapidly alleviated OFF episodes in Parkinsons dis-ease, but oral adverse effects may limit ... Apomorphine sublingual film (Kynmobi, Sunovion Pharmaceuticals) was efficacious and generally safe and well tolerated for the ... At the beginning of this study, patients in an OFF period received titrated doses of 10 to 35 mg of sublingual apomorphine in 5 ... There are no head-to-head comparisons of sublingual vs subcutaneous delivery of apomorphine. But based on experience, Pahwa ...
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Apomorphine has a catechol structure similar to that of dopamine. Several techniques exist for the creation of apomorphine from ... Apomorphine does not work in cats, who have too few dopamine receptors. Apomorphine (data page) Propylnorapomorphine Millan MJ ... This, along with the use of sublingual apomorphine tablets, led to a renewed interest in the use of apomorphine as a treatment ... Tompkins J (1899). "Apomorphine in Acute Alcoholic Delirium". Medical Record. "Apomorphine as a hypnotic". The Lancet. 155 ( ...
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Identify these minor or nonsignificant apomorphine subq (Apokyn Subq) interactions with the RxList drug interaction checker ... Medications known to have minor interactions with apomorphine subq. drug interactions checker , minor interactions for ... All generic drug interactions for apomorphine subq (lists will include brand and generic names): ...
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... an apomorphine infusion device for the continuous treatment of motor fluctuations (off episodes) in adults with Parkinson ... Apomorphine, a non-ergoline dopamine agonist, is believed to treat off episodes associated with Parkinson disease through ... Supernus receives notice assigning early October 2022 PDUFA for SPN-830 apomorphine infusion device NDA. News release. Supernus ... Close more info about Supernus One Step Closer to Decision on Apomorphine Infusion Device ...
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Vivonia CA Modification Of Apomorphine Hypothermia By Drugs Affecting Brain 5-hydroxytryptamine Function European Journal of ... One mg/kg dose of lysergic acid diethylamide (LSD) blocked apomorphine hypothermia. The apomorphine-blocking effect of both ... "Modification Of Apomorphine Hypothermia By Drugs Affecting Brain 5-hydroxytryptamine Function". European Journal of ... Intraperitoneal administration of apomorphine caused hypothermia in mice. Pretreatment with the Serotonin (5-HT) receptor ...
Erowid.org: Erowid Reference 2813 : Influence of LSD, Apomorphine and Monoamine synthesis: Inhibitors on the urge to obtain...
Apomorphine and Monoamine synthesis: Inhibitors on the urge to obtain water and seek Heterosexual contact in the female rat. ... "Influence of LSD, Apomorphine and Monoamine synthesis: Inhibitors on the urge to obtain water and seek Heterosexual contact in ... apomorphine, APO) and MAO inhibitors (p - chlorophenylalanine PGMCG and u-methyl-p-tyrosine, MT) were used. The influence.of ... "Influence of LSD, Apomorphine and Monoamine synthesis: Inhibitors on the urge to obtain water and seek Heterosexual contact in ...
Parkinson's disease, visual hallucinations and apomorphine: a review of the available evidence
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RESULTS: Apomorphine is well-tolerated in PD patients with VH, also in long-term follow-up studies. Apomorphine is also ... Apomorphine, Dopamine, Parkinsons disease, Serotonin, Visual hallucinations. UCL classification:. UCL. UCL , Provost and Vice ... Therefore apomorphine is still an option to consider in fluctuating PD patients with VH, if they are treated properly with ... METHODS: The aim of this study is to review the current evidence of apomorphine and its effects on VH in PD patients. ...
Stereochemical Characteristics of Dopamine Agonists: Molecular Structure of Bromocriptine and Structural Comparisons with...
The dopamine-like portion of the molecule has been compared conformationally with the active and inactive forms of apomorphine ... Molecular Structure of Bromocriptine and Structural Comparisons with Apomorphine. NORMAN CAMERMAN, LILIAN Y. Y. CHAN and ARTHUR ... Molecular Structure of Bromocriptine and Structural Comparisons with Apomorphine. NORMAN CAMERMAN, LILIAN Y. Y. CHAN and ARTHUR ... Molecular Structure of Bromocriptine and Structural Comparisons with Apomorphine. NORMAN CAMERMAN, LILIAN Y. Y. CHAN and ARTHUR ...
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The MDS-Device Aided Medical Therapy Module 1 course will provide a practical comparison of apomorphine, long-acting dopamine ... MDS-Device Aided Medical Therapy Module 1: A Practical Comparison of Apomorphine, Long-acting Dopamine Agonists, DBS and LCIG. ... 1. Describe how apomorphine, levodopa carbidopa, intestinal gel (LCIG), and deep brain stimulation (DBS) compare with each ... The MDS-Device Aided Medical Therapy Module 1 course will provide a practical comparison of apomorphine, long-acting dopamine ...
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Effects of apomorphine, a dopamine receptor agonist, on ocular refraction and axial elongation in a primate model of myopia
... ... Four of the monkeys received drops of 1% apomorphine HCl 2-3 times/day in the occluded eye; the four control monkeys received ... In contrast, they found that growth of the occluded and nonoccluded eyes of the apomorphine-treated monkeys was equivalent, ... The findings suggest that apomorphine administration retards excessive axial elongation and the concomitant development of ...
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Interested? - Apomorphine
Thank you for your interest in the use of apomorphine for the treatment of alcoholism.. The information you provide will only ... Do you consent for apomorphine.info to use your personal information and/or message to support our campaign for clinical trials ... Do you think there should be a clinical trial to test if apomorphine works?. *. Yes. ... to test Apomorphine as an alternative treatment for alcohol and other chemical or psychological dependencies? *. *. I am happy ...
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Medical Information - APOKYN® (apomorphine HCI)
Dopamine agonist - Wikipedia
Apomorphine[edit]. Apomorphine has a catechol element and belongs to a class called β-phenylethylamines and its main components ... Subramony JA (2006). "Apomorphine in dopaminergic therapy". Molecular Pharmaceutics. 3 (4): 380-5. doi:10.1021/mp060012c. PMID ... When apomorphine interacts with the dopamine receptor, or the ATP on the receptor, the catechol and nitrogen are important to ... Apomorphine (Apokyn - used to treat Parkinsons disease & Restless leg syndrome ) - biased at the D1 receptor.[40] ...
Patient Stories - Apomorphine
apomorphine (sublingual/injection)
Apomorphine may also be used for purposes not listed in this medication guide. ... Apomorphine is used to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with ... Measuring your apomorphine injection dose correctly is extremely important. The dose in an apomorphine injection pen is ... What is apomorphine?. Apomorphine is used to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people ...
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Apomorphine is used to treat off episodes when they occur. It is not used to prevent off episodes. This drug should not be ... Apomorphine is used to treat off episodes when they occur. It is not used to prevent off episodes. This drug should not be ... Before using apomorphine, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This ... Before using apomorphine, tell your doctor or pharmacist of all the drugs you take and if you have any of the following ...
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Apokyn9
- Apomorphine, sold under the brand name Apokyn among others, is a type of aporphine having activity as a non-selective dopamine agonist which activates both D2-like and, to a much lesser extent, D1-like receptors. (wikipedia.org)
- Apomorphine injection (Apokyn) is injected under the skin. (wayneunc.org)
- Apokyn is also referred to by its drug name, apomorphine. (myparkinsonsteam.com)
- Apokyn is not suitable for use in people who have previously shown hypersensitivity to apomorphine, sulfa drugs, or sulfites. (myparkinsonsteam.com)
- Apokyn (apomorphine) is good for treating the 'off' episodes or difficulty moving around when you have advanced Parkinson's disease, but it can cause vomiting and sudden sleepiness. (iodine.com)
- People respond to the injection of Apokyn (apomorphine) very quickly and this response can last longer than other medicines. (iodine.com)
- Apokyn (apomorphine) should only be used if you have an 'off' period of moving around. (iodine.com)
- Dosing can be confusing since the pen only dispenses in milliliters, and there have been reports of people getting overdoses of Apokyn (apomorphine) because they thought it was for milligrams. (iodine.com)
- Stopping Apokyn (apomorphine) suddenly or lowering the dose too quickly can cause your muscles to become very stiff and you might get a very high fever, which can be life threatening. (iodine.com)
Parkinson's13
- Apomorphine sublingual film ( Kynmobi, Sunovion Pharmaceuticals) was efficacious and generally safe and well tolerated for the on-demand treatment of OFF episodes in Parkinson's disease, long-term follow-up of a phase 3 study has shown. (medscape.com)
- Currently, apomorphine is used in the treatment of Parkinson's disease. (wikipedia.org)
- Apomorphine is used in advanced Parkinson's disease intermittent hypomobility ("off" episodes), where a decreased response to an anti-Parkinson drug such as L-DOPA causes muscle stiffness and loss of muscle control. (wikipedia.org)
- We are proposing to make changes to the funding of apomorphine hydrochloride, a medicine used to treat advanced Parkinson's disease, through an agreement with Stada. (pharmac.govt.nz)
- Apomorphine is used to treat "wearing-off" episodes (muscle stiffness, loss of muscle control) in people with Parkinson's disease. (wayneunc.org)
- Some anti-nausea medicines can increase certain side effects of apomorphine, or can make your Parkinson's symptoms worse. (wayneunc.org)
- Apomorphine (aporphine-10,11-diol, CA Registry Number 58004) is a non-narcotic derivative of morphine discovered in 1869 by Mattheisen [1] and it is a well-known potent short-acting dopamine agonist at D1 and D2 dopamine receptors, typically used in the treatment of patients with advanced Parkinson's disease (PD). (edu.sa)
- Apomorphine treats treats acute immobility episodes, also known as 'off periods', that occur in advanced Parkinson's Disease. (rxwiki.com)
- Apomorphine is a prescription medication used in the treatment of acute episodes of reduced mobility, also known as 'off periods', that can occur in advanced Parkinson's disease . (rxwiki.com)
- Apomorphine is a prescription medication used to treat acute episodes of reduced mobility, also known as 'off periods', that can occur in advanced Parkinson's disease . (rxwiki.com)
- The company has several transdermal products in clinical trials in the US, including an insulin patch providing basal levels of the hormone for diabetes treatment, an apomorphine hydrochloride patch for management of advanced Parkinson's disease, and a fentanyl citrate patch for moderate to severe pain management. (outsourcing-pharma.com)
- Apomorphine works by reducing the time of "off" or immobile periods in people previously treated for Parkinson's disease with levodopa (another treatment for Parkinson's disease ) and/or other dopamine agonists. (zeepedia.com)
- KYNMOBI ® (APL-130277) is a sublingual formulation of apomorphine approved for the treatment of OFF episodes in Parkinson's disease. (clinicaltrialsarena.com)
Hydrochloride2
- The net cost of Movapo 2 ml ampoule would be reduced from 1 January 2020 and Movapo would be the only funded brand of apomorphine hydrochloride until 30 June 2023. (pharmac.govt.nz)
- Apomorphine hydrochloride hemihydrate belongs to a group of medicines called dopamine agonists. (zeepedia.com)
Effects of apomorphine4
- Common side effects of apomorphine are nausea, yawning, and runny nose. (rxwiki.com)
- Metoclopramide has 28.8 nM affinity at the D2 receptor site and apomorphine 52nM (higher number = lower affinity) so theoretically metoclopramide may diminish the effects of apomorphine but I couldn't find any studies relating to this. (vtx-cpd.com)
- Dopamine transporter genotype dependent effects of apomorphine on cold pain tolerance in healthy volunteers. (cdc.gov)
- Shuddha Guggulu or capsules should be effects of apomorphine, induces release of lipid metabolism, showing high grade formula made a single reduce hunger and. (marsta.nu)
Effect of apomorphine3
- Some data suggest that the positive effect of apomorphine on VH is related to its piperidine moiety, part of many anti-psychotics. (ucl.ac.uk)
- Alcohol, antihypertensive medications, and vasodilating medications may potentiate the hypotensive effect of apomorphine. (apokynhcp.com)
- The effect of apomorphine sl. (psm.edu)
Suggest that apomorphine2
- The risk of developing VH with oral dopamine agonists seems to increase with advancing disease, while in contrast some clinical studies suggest that apomorphine does not worsen VH, or might even improve VH. (ucl.ac.uk)
- The findings suggest that apomorphine administration retards excessive axial elongation and the concomitant development of myopia associated with visual deprivation in primates. (nih.gov)
Administration of apomorphine2
- IV administration of apomorphine is highly discouraged, as it can crystallize in the veins and create a blood clot (thrombus) and block a pulmonary artery (pulmonary embolism). (wikipedia.org)
- Intraperitoneal administration of apomorphine caused hypothermia in mice. (erowid.org)
20221
- Supernus receives notice assigning early October 2022 PDUFA for SPN-830 apomorphine infusion device NDA. (empr.com)
Kynmobi2
- Apomorphine sublingual (Kynmobi) is placed under the tongue, where it will dissolve in about 3 minutes. (wayneunc.org)
- KYNMOBI is available as a sublingual film coated with apomorphine, which can be used up to five times a day at doses of between 10mg and 30mg. (clinicaltrialsarena.com)
Subcutaneous4
- However, it may have some advantages over subcutaneous apomorphine injections in terms of administration during OFF episodes. (medscape.com)
- New subjects could not have received subcutaneous apomorphine within 7 days of a screening visit. (medscape.com)
- SPN-830 provides a continuous subcutaneous infusion of apomorphine through an infusion pump. (empr.com)
- Apomorphine is available as a subcutaneous (under the skin) injection given at the onset of an "off period. (rxwiki.com)
Trimethobenzamide5
- Your doctor will give you another medication called trimethobenzamide to take when you begin to use apomorphine sublingual. (medlineplus.gov)
- Your doctor will probably tell you to begin taking trimethobenzamide 3 days before you begin to use apomorphine, and to continue taking it for up to 2 months. (medlineplus.gov)
- You should know that taking trimethobenzamide along with apomorphine may increase your risk of drowsiness, dizziness, and falls. (medlineplus.gov)
- antiemetics such as trimethobenzamide or domperidone, dopamine antagonists, are often used while first starting apomorphine. (wikipedia.org)
- To decrease the risk of nausea, your doctor may direct you to start taking another medication (e.g., trimethobenzamide) 3 days before your first dose of apomorphine and to continue taking as directed for up to 2 months. (blinkhealth.com)
Dose of apomorphine2
- Do not use a second dose of apomorphine sublingual for treatment of the same "off" episode. (medlineplus.gov)
- You will receive your first dose of apomorphine in a medical office where your doctor can closely monitor your condition to determine your dose. (medlineplus.gov)
Response to apomorphine4
- Psychooncology and cancer progression-related alterations of pleasure-associated neurochemical system: Abnormal neuroendocrine response to apomorphine in advanced cancer patients. (nel.edu)
- Lissoni P, Malugani F, Manganini V, Ardizzoia A, Gardani G, Bartolacelli E, Messina G, Tancini G. Psychooncology and cancer progression-related alterations of pleasure-associated neurochemical system: Abnormal neuroendocrine response to apomorphine in advanced cancer patients. (nel.edu)
- Mean LPPr was 76.8 ± 6.18 mm Hg at baseline and decreased by 50% after injury, with no response to apomorphine on day 7. (inserm.fr)
- Our data did not allow us to determine whether the impairment in erectile response to apomorphine preponderantly reflected arterial penile insufficiency or veno-occlusive dysfunction. (inserm.fr)
Hypotension3
- Profound hypotension and loss of consciousness reported when 5HT3 antagonists are coadministered with apomorphine. (medscape.com)
- Profound hypotension, loss of consciousness with apomorphine. (empr.com)
- Use with apomorphine (profound hypotension). (arogga.com)
Receptors11
- Contrary to its name, apomorphine does not actually contain morphine or its skeleton, nor does it bind to opioid receptors. (wikipedia.org)
- Dopamine antagonists, by their nature of competing for sites at dopamine receptors, reduce the effectiveness of the agonistic apomorphine. (wikipedia.org)
- Apomorphine improves motor function by activating dopamine receptors in the nigrostriatal pathway, the limbic system, the hypothalamus, and the pituitary gland. (wikipedia.org)
- Apomorphine, a non-ergoline dopamine agonist, is believed to treat off episodes associated with Parkinson disease through stimulation of postsynaptic dopamine D 2 -type receptors within the caudate-putamen in the brain. (empr.com)
- Apomorphine acts in D2 brain receptors known to be involved in sexual function. (medscape.com)
- The attenuation of cocaine-CPP by 7-OHDPAT likely involves stimulation of D 2 /D 3 autoreceptors in the mesolimbic pathway, whereas the potentiation of apomorphine-CPP likely involves stimulation of D 2 /D 3 postsynaptic receptors. (elsevier.com)
- Furthermore, it is suggested that attenuation of apomorphine- induced locomotion by 7-OH-DPAT likely involves stimulation of postsynaptic D 3 receptors in the mesolimbic pathway. (elsevier.com)
- Apomorphine is an a potent Dopamine 1 and (to a greater degree) Dopamine 2-'like' receptor agonist and also has an antagonistic effect on serotonergic receptors 5-HT2 and antagonist effects on alpha adrenergic receptors. (vtx-cpd.com)
- Metoclopramide and Apomorphine act on the same receptors and maropitant is the different one. (vtx-cpd.com)
- So when we give apomorphine this is where the action is happening on the D2 receptors. (vtx-cpd.com)
- Block by 5-hydroxytryptamine and apomorphine of recombinant human neuronal nicotinic receptors. (semanticscholar.org)
Inject apomorphine3
- Do not inject apomorphine into a vein. (wayneunc.org)
- Your healthcare provider will show you where on your body to inject apomorphine. (wayneunc.org)
- Do not inject apomorphine in your vein. (rxwiki.com)
Sublingual apomorphine1
- At the beginning of this study, patients in an OFF period received titrated doses of 10 to 35 mg of sublingual apomorphine in 5 mg increments during sequential office visits until they achieved a tolerable full ON within 45 minutes of a dose. (medscape.com)
Serotonin3
- Pretreatment with the Serotonin (5-HT) receptor antagonists methysergide (3 mg/kg), cinanserin (10 mg/kg) or brom-LSD (3 mg/kg) potentiated this response of apomorphine. (erowid.org)
- Irrespective this piperidine moiety, apomorphine has a high D1-like receptor affinity, and acts as a serotonin 5-HT2A receptor antagonist, which might explain the potential anti-hallucinogenic properties as well. (ucl.ac.uk)
- To investigate the effect of varying monoaminergic activity levels on motivation, a serotonin agonist (LSD), a dopamine agonist (apomorphine, APO) and MAO inhibitors (p - chlorophenylalanine PGMCG and u-methyl-p-tyrosine, MT) were used. (erowid.org)
Episodes3
- The Food and Drug Administration (FDA) has assigned a Prescription Drug User Fee Act (PDUFA) target date for SPN-830, an apomorphine infusion device for the continuous treatment of motor fluctuations (off episodes) in adults with Parkinson disease. (empr.com)
- Apomorphine is used to treat 'off' episodes when they occur. (blinkhealth.com)
- There have been reports of severe episodes of sudden drowsiness in a small number of patients using apomorphine. (rxwiki.com)
Precautions1
- See the "Apomorphine Precautions" section. (rxwiki.com)
Formulation1
- To identify the unknown vibrational spectrum of this compound, apomorphine bare salt and its commercial drug formulation (Apofin) were examined by means of Raman spectroscopy. (edu.sa)
Injection8
- Measuring your apomorphine injection dose correctly is extremely important. (wayneunc.org)
- The dose in an apomorphine injection pen is measured in milliliters (mL) marked on the pen. (wayneunc.org)
- One milligram, or 1 mg, of apomorphine is equal to 0.1 mL marked on the injection pen. (wayneunc.org)
- The medicine from an apomorphine injection pen can cause irritation if it gets in your eyes or on your skin. (wayneunc.org)
- If you stop using apomorphine injection for 7 days or longer , ask your doctor before restarting the medication. (wayneunc.org)
- By using a model of hemiparkinsonism in male rats, injection of the neurotoxic 6-OHDA in left striatum, we studied progesterone's effects on rotational behavior induced by amphetamine or apomorphine. (hindawi.com)
- He takes it each morning in advance of any use of apomorphine injections because it has prevented nausea and vomiting that he experienced after his first injection in the past. (neurologylive.com)
- To assess EF, we measured systemic and penile blood flow using penile laser Doppler and penile rigidity using a durometer before and after apomorphine injection. (inserm.fr)
Interactions1
- This is not a complete list of apomorphine drug interactions. (rxwiki.com)
Alcohol2
- Do you consent for apomorphine.info to use your personal information and/or message to support our campaign for clinical trials to test Apomorphine as an alternative treatment for alcohol and other chemical or psychological dependencies? (apomorphine.info)
- 2009. The dopamine agonist apomorphine differentially affects cognitive performance in alcohol dependent patients and healthy controls. . (nispa.nl)
Allergic3
- tell your doctor and pharmacist if you are allergic to apomorphine, any other medications, sulfites, or any other ingredients in apomorphine sublingual. (medlineplus.gov)
- You should not use apomorphine if you are allergic it. (wayneunc.org)
- Severe and potentially life-threatening allergic reactions are possible with apomorphine. (rxwiki.com)
Adverse effects3
- After that, your doctor will tell you to use apomorphine sublingual at home and to monitor for adverse effects. (medlineplus.gov)
- Besides the usual adverse effects with apomorphine, the sublingual film was associated with more oral adverse effects than seen with the injectable drug. (medscape.com)
- The risk or severity of adverse effects can be decreased when Apomorphine is combined with Epicriptine. (drugbank.com)
Patients6
- METHODS: The aim of this study is to review the current evidence of apomorphine and its effects on VH in PD patients. (ucl.ac.uk)
- RESULTS: Apomorphine is well-tolerated in PD patients with VH, also in long-term follow-up studies. (ucl.ac.uk)
- Therefore apomorphine is still an option to consider in fluctuating PD patients with VH, if they are treated properly with respect to their cholinergic deficits and existing VH. (ucl.ac.uk)
- Patients would continue to access funded apomorphine. (pharmac.govt.nz)
- Following approval by CRG and GMMMG, and by the Greater Manchester ICS Clinical Effectiveness and Governance Committee, the revised GMMMG shared care protocol for apomorphine for adult patients is now available. (gmmmg.nhs.uk)
- Some patients can stop taking Tigan after using apomorphine for several months. (rxwiki.com)
Induce5
- Historically, apomorphine has been tried for a variety of uses, including as a way to relieve anxiety and craving in alcoholics, an emetic (to induce vomiting), for treating stereotypies (repeated behaviour) in farmyard animals, and more recently in treating erectile dysfunction. (wikipedia.org)
- The emetic properties of apomorphine are exploited in veterinary medicine to induce therapeutic emesis in canines that have recently ingested toxic or foreign substances. (wikipedia.org)
- CONCLUSION: The anecdotal evidence suggesting that apomorphine has a relatively low proclivity to induce VH in PD may be due to its capacity to reduce serotonergic activity in particular. (ucl.ac.uk)
- por el contrario, la lesi n de este n cleo induce un incremento en la conducta antes mencionada. (medigraphic.com)
- Soon after Commander ingested the object, veterinary staff at the aquarium administered a dose of a drug called apomorphine, which is used to induce vomiting, in hopes that he would expel the foreign object. (bostonmagazine.com)
Infusion1
- Supernus resubmits NDA for SPN-830 apomorphine infusion device. (empr.com)
Injections1
- His treatment regimen has been changed recently and includes apomorphine injections: in his case, 0.3 mL of solution that's given subcutaneously, which was worked out by titration. (neurologylive.com)
Subcutaneously2
- When an episode sets in, the apomorphine is injected subcutaneously or applied sublingually, and signs subside. (wikipedia.org)
- Apomorphine injected subcutaneously can sometimes go to work within 5 to 10 minutes. (neurologylive.com)
Cause dizziness2
- you should know that if you use nitroglycerin under your tongue while using apomorphine sublingual, your blood pressure may decrease and cause dizziness. (medlineplus.gov)
- Apomorphine can also cause dizziness. (rxwiki.com)
Erectile dysfunction1
- Hydroxylated to apomorphine in erectile dysfunction in rats. (psm.edu)
Medication3
- This medication will help decrease your chance of developing nausea and vomiting while you are using apomorphine, especially during the beginning of treatment. (medlineplus.gov)
- Apomorphine may also be used for purposes not listed in this medication guide. (wayneunc.org)
- Apomorphine is a medication that stimulates both libido and erections and it works synergistically with Tadalafil. (vaulthealth.com)
Doses1
- Furthermore, 7-OHDPAT attenuated locomotion produced by high doses of apomorphine. (elsevier.com)
20201
- A new apomorphine 10 mg/ml, 5 ml ampoule would be funded from 1 February 2020. (pharmac.govt.nz)
Arterial2
- The priapism is caused by apomorphine increasing arterial blood supply to the penis. (wikipedia.org)
- Apomorphine increased baseline Doppler flow by 180% (95% confidence interval, 156-202%) and penile hardness from 3.49 ± 0.5 to 7.16 ± 0.82 Shore A units but did not change systemic arterial flow. (inserm.fr)
Ondansetron1
- apomorphine, ondansetron. (medscape.com)
Receptor2
- On the contrary, the 5-HT receptor agonists quipazine (3 mg/kg) and MK-212 (3 mg/kg), significantly blocked apomorphine hypothermia. (erowid.org)
- I guess the question pharmacologically is, does metoclopramide have greater affinity for the D2 receptor than apomorphine? (vtx-cpd.com)
Stimulates1
- Apomorphine stimulates dopamine in the brain to further stimulate the sexual response. (renewyouth.com)
Rats1
- IMSEAR at SEARO: Effect of intracisternally administered adenosine and inosine on apomorphine- and amphetamine-induced stereotyped behaviour in rats. (who.int)
Treatment7
- Apomorphine was also used as a private treatment of heroin addiction, a purpose for which it was championed by the author William S. Burroughs. (wikipedia.org)
- There is, however, no clinical evidence that apomorphine is an effective and safe treatment regimen for opiate addiction. (wikipedia.org)
- Thank you for your interest in the use of apomorphine for the treatment of alcoholism. (apomorphine.info)
- Read first-hand accounts by addicts who received the apomorphine treatment from Dr John Yerbury Dent. (apomorphine.info)
- Begun as an amplification on writings on apomorphine treatment for heroin addiction in the British Journal of Addiction (1957) and the. (jmichaelsbooks.com)
- EN] Emetics can be used to obtain food samples from birds, but they can harm birds during or after treatment. (upv.es)
- Schlatter, E. K. E. & Lal, S. (1972) Treatment of alcoholism using Dent's oral apomorphine method. (easyfamily.top)
Cynapsus2
- Toronto-based Cynapsus is developing APL 130277, a sublingual thin film strip containing apomorphine that dissolves much like the breath mint strips. (cynapsus.ca)
- The start-up hasn't disclosed which molecule it's working on, but Cynapsus' Giovinazzo said it's either levadopa or apomorphine. (cynapsus.ca)
Synthesis2
- Erowid.org: Erowid Reference 2813 : Influence of LSD, Apomorphine and Monoamine synthesis: Inhibitors on the urge to obtain water and seek Heterosexual contact in the female rat. (erowid.org)
- A Report on the Synthesis of the Apomorphine Form. (jmichaelsbooks.com)
Prolongation1
- Additionally, dolasetron may cause additive QT prolongation with apomorphine. (medscape.com)
Drugs2
- Some drugs should not be used together with apomorphine. (wayneunc.org)
- Apomorphine belongs to a group of drugs called non-ergoline dopamine agonists. (rxwiki.com)
Vein1
- Injecting apomorphine into a vein (intravenous) can cause blood clots. (rxwiki.com)
Acute1
- Thesis title: Effects of acute and chronic apomorphine on sexual behavior and copulation-induced neural activation in the male rat. (rug.nl)
Healthcare provider1
- What should I discuss with my healthcare provider before using apomorphine? (wayneunc.org)
Drug2
- It was concluded that 5-HT modulates the dopamine (DA)-mediated body temperature changes and that drug induced alterations in the brain 5-HT function modify apomorphine-induced hypothermia in a predictable manner. (erowid.org)
- In the Raman spectrum of apomorphine (both bare salt and commercial drug), two strong characteristic signals werefound,whichwereassignedwiththehelpoffirst-principlescalculations:thebandat1589cm -1 (assignedtothestretching mode of the B aromatic ring coupled with C-H in-plane bending) and the band at 1302 cm -1 (assigned to O-H in-plane bending and CH 2 twisting and wagging vibrations). (edu.sa)
Cocaine4
- This study further examined the effects of 7-OH-DPAT on behaviors produced by the indirect DA agonist, cocaine, and the non-selective direct DA agonist, apomorphine. (elsevier.com)
- To examine whether 7-OH-DPAT would alter cocaine and apomorphine dose-response curves for motor behaviors and CPP, 0.1 mg/kg 7-OH-DPAT was co-administered with 0- 30 mg/kg cocaine and 0-3 mg/kg apomorphine. (elsevier.com)
- 7-OH-DPAT enhanced cocaine- and apomorphine-induced stereotypies following repeated administration. (elsevier.com)
- 7-OH-DPAT also attenuated cocaine-CPP, but potentiated apomorphine-CPP. (elsevier.com)