A piperidinyl isoindole originally introduced as a non-barbiturate hypnotic, but withdrawn from the market due to teratogenic effects. It has been reintroduced and used for a number of immunological and inflammatory disorders. Thalidomide displays immunosuppressive and anti-angiogenic activity. It inhibits release of TUMOR NECROSIS FACTOR-ALPHA from monocytes, and modulates other cytokine action.
Errors or mistakes committed by health professionals which result in harm to the patient. They include errors in diagnosis (DIAGNOSTIC ERRORS), errors in the administration of drugs and other medications (MEDICATION ERRORS), errors in the performance of surgical procedures, in the use of other types of therapy, in the use of equipment, and in the interpretation of laboratory findings. Medical errors are differentiated from MALPRACTICE in that the former are regarded as honest mistakes or accidents while the latter is the result of negligence, reprehensible ignorance, or criminal intent.
Truthful revelation of information, specifically when the information disclosed is likely to be psychologically painful ("bad news") to the recipient (e.g., revelation to a patient or a patient's family of the patient's DIAGNOSIS or PROGNOSIS) or embarrassing to the teller (e.g., revelation of medical errors).
The interactions between physician and patient.
Attitudes of personnel toward their patients, other professionals, toward the medical care system, etc.
A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
An agent that causes the production of physical defects in the developing embryo.
Substances that suppress Mycobacterium leprae, ameliorate the clinical manifestations of leprosy, and/or reduce the incidence and severity of leprous reactions.
Inorganic or organic compounds that contain the basic structure RB(OH)2.
Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.
An anti-inflammatory 9-fluoro-glucocorticoid.
Gross hypo- or aplasia of one or more long bones of one or more limbs. The concept includes amelia, hemimelia, phocomelia, and sirenomelia.
An erythematous eruption commonly associated with drug reactions or infection and characterized by inflammatory nodules that are usually tender, multiple, and bilateral. These nodules are located predominantly on the shins with less common occurrence on the thighs and forearms. They undergo characteristic color changes ending in temporary bruise-like areas. This condition usually subsides in 3-6 weeks without scarring or atrophy.
Acquired degenerative dilation or expansion (ectasia) of normal BLOOD VESSELS, often associated with aging. They are isolated, tortuous, thin-walled vessels and sources of bleeding. They occur most often in mucosal capillaries of the GASTROINTESTINAL TRACT leading to GASTROINTESTINAL HEMORRHAGE and ANEMIA.
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The imide of phthalic acids.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.
Treatment designed to help prevent a relapse of a disease following the successful primary treatments (INDUCTION CHEMOTHERAPY and CONSOLIDATION CHEMOTHERAPY) with a long-term low-dose drug therapy.
A therapeutic approach, involving chemotherapy, radiation therapy, or surgery, after initial regimens have failed to lead to improvement in a patient's condition. Salvage therapy is most often used for neoplastic diseases.
A recurrent disease of the oral mucosa of unknown etiology. It is characterized by small white ulcerative lesions, single or multiple, round or oval. Two to eight crops of lesions occur per year, lasting for 7 to 14 days and then heal without scarring. (From Jablonski's Dictionary of Dentistry, 1992, p742)
A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.
A chronic communicable infection which is a principal or polar form of LEPROSY. This disorder is caused by MYCOBACTERIUM LEPRAE and produces diffuse granulomatous skin lesions in the form of nodules, macules, or papules. The peripheral nerves are involved symmetrically and neural sequelae occur in the advanced stage.
Congenital structural deformities of the upper and lower extremities collectively or unspecified.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Biologically active substances whose activities affect or play a role in the functioning of the immune system.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
Persons who have experienced a prolonged survival after serious disease or who continue to live with a usually life-threatening condition as well as family members, significant others, or individuals surviving traumatic life events.
Parliamentary democracy located between France on the northeast and Portugual on the west and bordered by the Atlantic Ocean and the Mediterranean Sea.
Eating an excess amount of food in a short period of time, as seen in the disorder of BULIMIA NERVOSA. It is caused by an abnormal craving for food, or insatiable hunger also known as "ox hunger".
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
A situation in which an individual might benefit personally from official or professional actions. It includes a conflict between a person's private interests and official responsibilities in a position of trust. The term is not restricted to government officials. The concept refers both to actual conflict of interest and the appearance or perception of conflict.
Individuals subjected to and adversely affected by criminal activity. (APA, Thesaurus of Psychological Index Terms, 1994)
A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.
Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)
The group in which legal authority is vested for the control of health-related institutions and organizations.
Mobilization of human, financial, capital, physical and or natural resources to generate goods and services.
The amounts spent by individuals, groups, nations, or private or public organizations for total health care and/or its various components. These amounts may or may not be equivalent to the actual costs (HEALTH CARE COSTS) and may or may not be shared among the patient, insurers, and/or employers.
Detailed financial plans for carrying out specific activities for a certain period of time. They include proposed income and expenditures.
Character traits that are considered to be morally praiseworthy. (Bioethics Thesaurus)
The state of not being engaged in a gainful occupation.
A species of gram-positive bacteria in the STREPTOCOCCUS MILLERI GROUP. It is commonly found in the oropharnyx flora and has a proclivity for abscess formation in the upper body and respiratory tract.
A traditional grouping of drugs said to have a soothing or calming effect on mood, thought, or behavior. Included here are the ANTI-ANXIETY AGENTS (minor tranquilizers), ANTIMANIC AGENTS, and the ANTIPSYCHOTIC AGENTS (major tranquilizers). These drugs act by different mechanisms and are used for different therapeutic purposes.
Using an INTERNET based personal journal which may consist of reflections, comments, and often hyperlinks.
The heath plant family of the order Ericales, subclass Dilleniidae, class Magnoliopsida that are generally shrubs or small trees. Leaves are alternate, simple, and leathery; flowers are symmetrical with a 4- or 5-parted corolla of partly fused petals.
Time period from 1901 through 2000 of the common era.
The study of the structure, growth, function, genetics, and reproduction of bacteria, and BACTERIAL INFECTIONS.
Infestation of animals with parasitic worms of the helminth class. The infestation may be experimental or veterinary.
Collaborative process of research involving researchers and community representatives.
Thalidomide apology insulting, campaigners say BBC News 1 September 2012. Accessed 31 March 2017 https://www.abc.net.au/news/ ... Working with P H Huang, he proposed that thalidomide caused malformations by interacting with the DNA of the dividing embryonic ... He published a letter on the teratogenicity of thalidomide following the findings of a midwife called Pat Sparrow, which ... Retrieved 26 July 2010 Thalidomide hero found guilty of scientific fraud - The New Scientist, 27 February 1991 "Time Magazine" ...
"Thalidomide Maker Issues Apology". UPI. 1 September 2020. Retrieved 11 May 2020. Crawford, Angus (14 October 2013). " ... In November 1961, thalidomide was thus taken off the market. Thalidomide caused severe deformities in the children of women who ... 50 million to the Thalidomide Foundation to help to improve the lives of thalidomide victims. In August 2012, the company ... Thalidomide had only been tested on rodents, as was usual practice at the time. In the UK, the British pharmaceutical company ...
As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide "Apology for ... "Thalidomide apology insulting, campaigners say". BBC News. September 1, 2012. Archived from the original on 16 March 2016. ... "Thalidomide Monograph for Professionals". Drugs.com. Retrieved 14 November 2019. "Thalidomide: The Fifty Year Fight (no longer ... At the time of the apology, there were 5,000 to 6,000 sufferers still alive. Victim advocates called the apology "insulting" ...
It recommended that "the Government should immediately issue a fulsome apology on behalf of the healthcare system to the ... Is this the forgotten thalidomide?'". Daily Telegraph. Archived from the original on 14 July 2017. Department of Health, ...
"Thalidomide apology insulting, campaigners say". BBC News. September 1, 2012. "New fund announced to help disabled people into ... "Compensation offer on Thalidomide". BBC News. 7 July 2005. Retrieved 26 July 2011. "Thalidomide survivors to get £20m". BBC ... At the time of the apology, there were 5,000 to 6,000 sufferers still alive. Victim advocates called the apology "insulting" ... 2012 - On 17 July 2012, Lynette Rowe of Australia (who was born without limbs due to thalidomide) was awarded an out-of-court ...
Treviño's first blog post was an apology for a controversial tweet posted in June 2011 over the second Gaza flotilla, the ... The Economist's Intelligent Life magazine opined that... As Watergate is to the Washington Post, and thalidomide to the Sunday ... Brooker and the paper issued an apology, saying the "closing comments were intended as an ironic joke, not as a call to action ...
... "offer an unreserved apology", however he believed "that the judgement is unsound and will be found wanting on appeal." The ... worst child poisoning case since thalidomide". The Daily Telegraph. London. Retrieved 2009-07-30. CS1 maint: discouraged ... the council sincerely hopes that this apology coupled with today's agreement will mean that they can now put their legal battle ...
This regulation was influenced by the results of 1950 use of thalidomide in Western Europe for pregnant women. They were ... The US Secretary of State Hillary Clinton issued an official apology to Guatemala. President Barack Obama apologized to ... University of Adelaide (2002-02-08). "APOLOGY FOR PAST EXPERIMENTS ON ABORIGINAL PEOPLE". Retrieved 2018-08-04.CS1 maint: uses ... and the school issued a formal apology to Aboriginal and Torres Strait Islander groups. Canada has historically carried out ...
Happy Birthday Thalidomide, Producer: Kim Flitcroft (UK) Best of Festival - Whole- a trinity of being, Producer: Shelley Barry ... No Apologies, Producer: Peni Hall; Associate Producer, Pandoura Carpenter Merit Award (Content) - The Power of 504, Producer: ...
... the newspaper issued an apology. Journalist Ian Burrell, writing in The Independent, described the apology as an "indication of ... On 19 May 1968, the paper published its first major campaigning report on the drug Thalidomide, which had been reported by the ... Some of the more notable or controversial stories published in The Sunday Times include: Thalidomide, a drug prescribed to ... The newspaper published a four-page Insight investigation, entitled The Thalidomide File, in the Weekly Review section. A ...
"NOFX Issue Apology for Las Vegas Shooting Joke - Pitchfork". pitchfork.com. Daly, Rhian (June 22, 2018). "NOFX say they've had ... NOFX's first recording was a demo from 1984, entitled Thalidomide Child, produced by Germs drummer Don Bolles, which did not ...
... apology made by the German drug firm that produced the drug. ... Thousands of Thalidomide victims, who were born disabled as a ... German Thalidomide Producer Makes First Apology, in 50 Years. The German firm that made thalidomide has issued its first ... A Japanese support group for Thalidomide victims also said the apology was not good enough. "An apology is a matter of course ... Thousands of Thalidomide victims, who were born disabled as a result of its use, rejected the "insult" apology made by the ...
Thalidomide apology * Posted2012-09-10 13:45. On August 31st, German company Grunenthal issued an apology to all the victims of ... the thalidomide birth defects tragedy. This is the first apology that has been issued by the company since the drug was ...
As they report in the current issue of Science, a protein known as cereblon latched on tightly to the thalidomide "Apology for ... "Thalidomide apology insulting, campaigners say". BBC News. September 1, 2012. Archived from the original on 16 March 2016. ... "Thalidomide Monograph for Professionals". Drugs.com. Retrieved 14 November 2019. "Thalidomide: The Fifty Year Fight (no longer ... At the time of the apology, there were 5,000 to 6,000 sufferers still alive. Victim advocates called the apology "insulting" ...
AP)-Spanish victims of thalidomide on Wednesday published documents they claim prove a German drug company kept distributing ... German drug firm makes 1st apology for thalidomide (Update). August 31, 2012 (AP)-The German manufacturer of a notorious drug ... Victims: Thalidomide sold in Spain post-withdrawal. May 8, 2013 by Jorge Sainz (AP)-Spanish victims of thalidomide on Wednesday ... Thalidomide maker ignored birth defects for years. July 27, 2012 The German makers of thalidomide were warned of birth ...
Thalidomides Big Lie Overshadows Corporate Apology, 2012). "Thalidomides Partner in Crime". In 1998, the FDA approved ... Thalidomides Big Lie Overshadows Corporate Apology, Reuters, Sept. 2012). Thalidomiders called the apology an insult to ... Thalidomides Big Lie Overshadows Corporate Apology, Reuters, 2012. Frances M.V. Hackney. How Goliath Killed David, Annals ... Thalidomide Genocide: Saga of a Wonder Drug The New Indian Express, Sept. 20, 2012. Tom Rowley. Thalidomide: The Fifty Year ...
Thalidomide apology insulting, campaigners say BBC News 1 September 2012. Accessed 31 March 2017 https://www.abc.net.au/news/ ... Working with P H Huang, he proposed that thalidomide caused malformations by interacting with the DNA of the dividing embryonic ... He published a letter on the teratogenicity of thalidomide following the findings of a midwife called Pat Sparrow, which ... Retrieved 26 July 2010 Thalidomide hero found guilty of scientific fraud - The New Scientist, 27 February 1991 "Time Magazine" ...
Call it Gavuras Law, with apologies to Mike Godwin:. As an online discussion on the effectiveness of alternative medicine ... Does Thalidomide Invalidate Science-Based Medicine?. Cases like thalidomide provide a good example of why SBM authors argue ... The Resurrection of Thalidomide. Almost 30 years after thalidomide was withdrawn, its back on the market in the United States ... And that leads to the logical fallacies that the thalidomide retort represents. Thalidomide is an effective drug for some ...
And the demands for an apology and compensation are getting louder. Hopefully, answers will soon be forthcoming. Early in 2015 ... It will hopefully determine, once and for all, whether Primodos deserves to be called "the forgotten thalidomide". ... as demonstrated for thalidomide. However, theres an approximate 3% rate of naturally occurring birth defects in the world. So ...
Reuters, 19 September 2012: Thalidomides big lie overshadows corporate apology. A powerful and moving article - as is the book ... Thalidomide would be pronounced safe by animal tests even today. Dr JL Schardein, an authority on birth defects, states; "In ... But another dreadful legacy of thalidomide is the regulations it spawned: enshrining in law a system of animal testing that ... Lee Jones claim that more animal tests would have averted the thalidomide tragedy (letters, September) is simply untrue. ...
Then where are the apologies from the doctors who prescribed it???)... ... Thalidomide was never approved for use in pregnant women in the United States. ( ... Thalidomide victims reject insulting apology. 31 Aug.`12 - Thalidomide survivors on Saturday rebuffed an apology by the ... Then where are the apologies from the doctors who prescribed it???). German drug firm makes 1st apology for thalidomide. Aug 31 ...
... a Thalidomide baby condemned to advanced years. He has become such a fixture that surely every person passing him by day to day ... Apology not accepted. YOU were standing by the jeepney stop in front of the Faculty Center. How you got there, I dont know. It ... The feeling one has when ones soul wants to vomit: why did you say sorry to me? You should have said, "apology not accepted". ... Since you apologized over my apology, I have encountered many who remind me of you, though none exactly like you. Just the ...
... along with a meaningful gesture of apology -- and ideally compensation -- from Grunenthal, the company responsible for ... They speculate that thalidomide was involved, which makes me wonder how many more of us there are. When I was younger, a woman ... We were labeled "Thalidomide Babies." Cripples. Half a century ago stories such as ours were the stuff of nightmares, human ... Now, we would like to call on the media for deeper coverage of the truth about thalidomide and its U.S. victims, as well as on ...
SEE: Britain apologizes to thalidomide victims. http://edition.cnn.com/2010/WORLD/europe/01/14/uk.thalidomide.apology/index. ...
Welsh people left disabled by the thalidomide drug scandal are being backed in their fight for compensation by Plaid Cymru MEP ... and in 2009 the then Labour UK government issued an apology and promised a further £20m compensation. ... There are more than 460 thalidomide survivors in the UK. *Thalidomide is still used today to treat the complications of leprosy ... Thalidomide fact file. *Developed by German pharmaceutical company Grunenthal. *Launched in Germany in October 1957 under the ...
The most famous example of the dangers of animal testing is the Thalidomide tragedy of the 1960s and 1970s. Thalidomide, which ... German-based Gruenenthal has issued its first apology in 50 years, but said the drugs possible side-effects could not be ... Thalidomide was tested prior to use, but the testing for the primary use was not for pregnant women. The marketing for women ... That is what some of the blog sources wish to imply, but it is not what the research papers say of Thalidomide. As for any ...
SciAmBlogs Thursday - Thalidomide, coral guards, tool-using cockatoo, carnivorous harp sponge, last Ethiopian wolves, and more. ... unexpectedly issuing an apology to the victims of its teratogenic drug-babies who sustained life-long wounds inflicted by their ... From the Holocaust to Thalidomide: A Nazi Legacy. I was attending World Federation of Jewish Child Survivors of the Holocaust ... Judy Stone - From the Holocaust to Thalidomide: A Nazi Legacy - Christie Wilcox - Coral Recruits Goby Bodyguards Against ...
Tragic Thalidomide victims havefinally received a pounds 20 millionpay off and a belatedapologyfromthe Government.But many ... A long-awaited apology for Thalidomide victims was made in Parliament on Thursday and a pounds 20 million grant from the ... KARL Murphy was born with limb deformities 37 years ago that have nothing to do with Thalidomide. He had no toes on his left ... "We are planning to team up with the Thalidomide Trust to try and have a greater impact because victims need people to know the ...
I have been reading mental health stuff for years and have never heard of an apology from the psycho pharma industry for any of ... Sunday 2 September 2012 , Gruenenthal Groups CRO has apologized to mothers who took Thalidomide in the 1950s and 1960s and ... Correction: I read about an apology once before. ... Exactly 50 years ago today, Thalidomide was pulled off the ...
Oh yeah? Thalidomide! Wheres your science now?. Online discussions on the merits of alternative medicine can get quite heated ... Call it Gavuras Law, with apologies to Mike Godwin: As an online discussion on the effectiveness of alternative medicine grows ... longer, the probability that thalidomide will be cited approaches one. A... ...
"In 1959, thalidomide began being sold and issued as a "safe and non-toxic drug without side-effects" and suitable as an ... I am calling on the government to issue the apology that is owed, alongside a statutory healthcare package to meet the needs of ... "The 32 survivors of Thalidomide are entitled to justice for what they have to go through daily. The state has a role in this. ... Ó Snodaigh calls for justice for Thalidomide survivors 20 March, 2013 - by Aengus Ó Snodaigh TD ...
Im lucky to have the arm down to the elbow-many thalidomide babies have only a bulbous lump at the shoulder-and Im lucky to ... How could she have known? Poor Mother, prone to fits of apology for taking the drug. I dont recall a time when I didnt know ... Maybe she should have stopped to consider that taking thalidomide might harm me. Havent pregnant women through the ages ... that taking thalidomide for nausea during pregnancy caused malformed fetuses. ...
Thalidomide drug scandal victory in sight - Benzo Drug Scandal Continues. Thalidomide drug scandal victory in sight ... Did we ever hear a word of apology when events proved this government scientific adviser wrong? We hear a lot about the bovine ... The British state would also issue a public apology for its role in the tragedy. Campaigners for the victims have been ... THE government is proposing a multi-million-pound settlement for the surviving victims of thalidomide in an attempt to lay to ...
Last Friday, Gruenethal, the German pharmaceutical firm responsible for the drug, claimed to be making public apology for its ... i understand thalidomide wasnt developed until the early 50s. what i am trying to learn is what would have been used by a ... But the Thalidomide birth defects crisis put a new face on the dangers of modern pharmacology, revealing to the world that ... Forgetting The Lessons Of The Thalidomide Birth Defects Crisis. Few words convey the ability of modern medicine to do harm like ...
Pingback: Thalidomide Apology 50 Years Later. * David Hill. says: August 11, 2012 at 2:32 pm ...
"Opinion: Why Thalidomide Apology Is Not Enough." CNN. 6 Sept. 2012. Web. 1 May 2014. ... something Thalidomide survivors found offensively paltry. As Geoff Adams-Spink says, "Thalidomide has deprived us of the lives ... A drug called Thalidomide, derived from a chemical used for war crimes during the Holocaust, is heralded as the worst drug ... The scandal sounds old, yet it was only in 2012 that the head of Grunenthal made amends, offering only a public apology, ...
Although the apology included this pathetic line:. We also apologize for the fact that we have not found the way to you from ... In most countries the Thalidomide children became Thalidomide adults, now in their 50s, and there were no more Thalidomide ... News Politicians 1968 In Photos: The High Court Agrees Meagre Compensation For Thalidomide Victims Thalidomide ... A Thalidomide baby born without arms at a party given at Hamilton Terrace, London to mark the first anniversary of Lady Hoare ...
... finally issued a formal apology to victims of thalidomide. In the apology, Grünenthal CEO Harald Stock said:. We ask for ... Thalidomide survivors and their families called the apology an "insult to the victims of the drug."15. Referenc ... Thalidomide Still in Use. Despite the horrors associated with its previous use, thalidomide is in limited and carefully ... I had suspected thalidomide to be the cause of an outbreak of limb and ear malformation in Western Germany for the first time ...
Examples like Thalidomides effects on fetuses dont qualify, because the treatment (give women Thalidomide) was not to prevent ... That would be the Thalidomide that TheBrummell mentioned, post #42 (for the moment). ... Apologies, my unedited version went through. Dyslexia sucks.. * Randy Owens says 30 May 2007 at 8:24 pm. ...
Thalidomide survivors owed apology, compensation from Government: Senate report , 9 News. Whats happened to Thalidomide babies ... A thalidomide survivor. Photo: EP. Thalidomide Group Australia, a group that advocates for the ongoing health needs of aging ... THALIDOMIDE BABIES. Fifty years ago, one of the most extreme cases of Big Pharma getting it wrong in Australia was the ... Thalidomide has strong sedative properties and many women in the early weeks of pregnancy took the drug, utterly unaware its ...
Could this apology be preparing us for thalidomides approval for some of these other conditions discussed in the piece? Sadly ... A German victims group rejected the companys apology as too little, too late.. "The apology as such doesnt help us deal with ... Makers of Thalidomide Apologize...50 Years Later. Excerpts from USA Today. The German manufacturer of a notorious drug that ... Thalidomide is still sold today, but as a treatment for multiple myeloma, a bone marrow cancer and leprosy. It is also being ...
  • German paediatrician Widukind Lenz, who also suspected the link, is credited with conducting the scientific research that proved thalidomide was causing birth defects in 1961. (wikipedia.org)
  • Gruenenthal withdrew thalidomide in 1961. (medicalxpress.com)
  • McBride published a letter in The Lancet, in December 1961, noting a large number of birth defects in children of patients who were prescribed thalidomide, after a midwife called Sister Pat Sparrow first suspected the drug was causing birth defects in the babies of patients under his care at Crown Street Women's Hospital in Sydney. (wikipedia.org)
  • In 1961, two independent researchers identified thalidomide as the likely causal agent. (sciencebasedmedicine.org)
  • Thalidomide was yanked from the market in 1961 and was also found to cause defects in the eyes, ears, heart, genitals and internal organs of developing babies. (usmessageboard.com)
  • By 1961, two doctors working independently of each other made the connection between thalidomide use and the rash of children born with a particular set of deformities characterized by "phocomelia," shortened, flipper-like or missing limbs or ears, and often including severely abnormal internal organs. (blogspot.com)
  • It was not until the thalidomide tragedy in 1961 that the regulation was put in place. (aol.co.uk)
  • Thousands of Thalidomide victims, who were born disabled as a result of its use, rejected the "insult" apology made by the German drug firm that produced the drug. (medindia.net)
  • In its first apology for the scandal in 50 years, Grunenthal said on Friday it was "very sorry" for its silence towards victims of the drug, which was sold to pregnant women in the 1950s and early 1960s to cure morning sickness. (medindia.net)
  • But victims said the apology was too little, too late for the estimated 10,000 children worldwide who were born with defects -- including missing limbs -- after their mothers took thalidomide. (medindia.net)
  • Freddie Astbury, president of the charity Thalidomide UK, said Grunenthal needed to "put their money where their mouth is" and compensate victims rather than simply saying sorry. (medindia.net)
  • A Japanese support group for Thalidomide victims also said the apology was not good enough. (medindia.net)
  • Stock said his firm was taking steps to help thalidomide victims. (medindia.net)
  • It is not known exactly how many worldwide victims of thalidomide embryopathy there have been, although estimates range from 10,000 to 20,000. (wikipedia.org)
  • The Spanish advocacy group for victims of thalidomide estimates that in 2015, there were 250-300 living victims of thalidomide in Spain. (wikipedia.org)
  • AP)-Spanish victims of thalidomide on Wednesday published documents they claim prove a German drug company kept distributing the notorious drug in Spain six months after it was taken off the market in other countries. (medicalxpress.com)
  • The Spanish Association of Thalidomide Victims released documents it said prove the distributor delivered thalidomide tablets to Spain until May 1962. (medicalxpress.com)
  • The Spanish victims intend to present the documents about the distribution of thalidomide tablets when its lawsuit against Gruenenthal begins at a Madrid court on Oct. 14, said Jose Riquelme, head of the association, which has about 200 members. (medicalxpress.com)
  • The criminal charges were dropped and Grünenthal agreed to pay German thalidomide victims $31 million, with the German government contributing an additional amount. (ahrp.org)
  • Thereafter, a series of local laws, some specially enacted to protect Grünenthal, bars German thalidomide victims from suing the company. (ahrp.org)
  • We want to call on the media for deeper coverage of the truth about thalidomide and its U.S. victims, along with a meaningful gesture of apology -- and ideally compensation -- from Grunenthal, the company responsible for developing and mass marketing the drug that has had such devastating effects on the lives of so many -- reported or not. (huffpost.com)
  • The story was prompted by the drug developer, Germany's Grünenthal, unexpectedly issuing an apology to the victims of its teratogenic drug-babies who sustained life-long wounds inflicted by their drug more than 50 years earlier.I've written some about thalidomide previously, in my initial Clinical Trials for Beginners posts, (here and here). (scientificamerican.com)
  • Tragic Thalidomide victims havefinally received a pounds 20 millionpay off and a belatedapologyfromthe Government.But many otherfamilies whoclaim theirlives have beenruined byanother drug onceused inpregnancy testing arestill waiting in hope plight will one daythat their be recognised by the ALISON DAYANI reports. (thefreelibrary.com)
  • But, unlike the high-profile Thalidomide victims, people like Karl, now a leading member of the Association for Children Damaged by Hormone Pregnancy Tests, fear they are in danger of being forgotten. (thefreelibrary.com)
  • We are planning to team up with the Thalidomide Trust to try and have a greater impact because victims need people to know the story of the Primidos saga. (thefreelibrary.com)
  • THE government is proposing a multi-million-pound settlement for the surviving victims of thalidomide in an attempt to lay to rest the long-running drug scandal. (benzo.org.uk)
  • The victims, who were born with deformed arms and legs or with brain damage after their mothers took the thalidomide anti-morning sickness pills, are now facing spiralling medical and living costs as their bodies start to fail because of the unnatural stresses placed on them. (benzo.org.uk)
  • The German manufacturers Grunenthal have never admitted liability to the British victims nor have they contributed to the Thalidomide Trust . (flashbak.com)
  • A German victims group rejected the company's apology as too little, too late. (blogspot.com)
  • The apology as such doesn't help us deal with our everyday life," said Ilonka Stebritz, a spokeswoman for the Association of Contergan Victims. (blogspot.com)
  • Victims of Thalidomide began a campaign to claim ВЈ3.2 billion in compensation. (intersolicitors.co.uk)
  • More than 10,000 babies worldwide were born with limb deformities and other problems linked to thalidomide before it was withdrawn by its German manufacturer Grunenthal. (bbc.co.uk)
  • A statement from Grunenthal said: "Thalidomide is part of our history and always will be and we have accepted a responsibility to offer help. (flashbak.com)
  • In the late 1950s and early 1960s, the use of thalidomide in women, some of which were pregnant or got pregnant after, in 46 countries resulted in the "biggest man‐made medical disaster ever", resulting in more than 10,000 children born with a range of severe deformities, such as phocomelia, as well as thousands of miscarriages. (wikipedia.org)
  • One of the horrific and still negligently under-reported legacies of the Baby Boom era was the widespread use of thalidomide by pregnant women, which led to countless, yet still vastly undocumented, cases of children born in the United States and abroad with severe deformities, including the lack of limbs, hands, fingers and toes. (huffpost.com)
  • KARL Murphy was born with limb deformities 37 years ago that have nothing to do with Thalidomide. (thefreelibrary.com)
  • If reproductive tests had been done on thalidomide, they would not necessarily have shown precisely what deformities would be produced, dependent on the time of ingestion in relation to the development of the fetus, but they would certainly have shown that drugs could endanger unborn children in some way. (litigationandtrial.com)
  • ON this day in photos - February 19 1968: the High Court orders damages to be paid to 62 children born with deformities, after their mothers took the drug thalidomide during pregnancy. (flashbak.com)
  • This April 7, 1998 file photo shows capsules of the drug thalidomide at the Celgene Corp. in Warren, N.J, printed with a symbol warning pregnant or soon-to-be pregnant women against use of the drug that had caused thousands of infant deformities. (flashbak.com)
  • Within a few years after introduction of thalidomide, it became clear that the drug will killing many babies and causing severe deformities among many of the children who survived. (blogspot.com)
  • At least 207 of the study patients were pregnant during the study period and 17 are known to have given birth to infants with typical thalidomide-induced deformities 9 It is estimated that about 40 thalidomide-affected babies were born in the U.S, 10 but that was a relatively small number compared to other parts of the world, where upwards of 10,000 infants were affected. (blogspot.com)
  • By the mid 1960s he had visited no less than 2,400 children who had been deformed by thalidomide. (ahrp.org)
  • The most famous example of the dangers of animal testing is the Thalidomide tragedy of the 1960s and 1970s. (envirolink.org)
  • Sunday 2 September 2012 , Gruenenthal Group's CRO has apologized to mothers who took Thalidomide in the 1950s and 1960s and gave birth to children with congenital birth defects. (madinamerica.com)
  • Gruenenthal Group's chief executive said Friday the company wanted to apologize to mothers who took the drug Thalidomide during the 1950s and 1960s and to their children who suffered congenital birth defects as a result. (blogspot.com)
  • IRBs were set up in the 1960s in response to the progressive revelations of the Nazi medical experiments (1939-1945), the Thalidomide tragedy (1957-1962), and the Tuskegee Syphilis Study (1932-1972), plus dozens of other unethical medical trials. (blogspot.com)
  • Thalidomide babies were often born with missing or extremely short arms and legs. (medindia.net)
  • Although the Australian obstetrician William McBride took credit for raising the alarm about thalidomide, it was a midwife called Sister Pat Sparrow who first suspected the drug was causing birth defects in the babies of patients under McBride's care at Crown Street Women's Hospital in Sydney. (wikipedia.org)
  • As noted above, the East German regulators did not approve the drug, so there were no babies born deformed from thalidomide in East Berlin. (ahrp.org)
  • We were labeled "Thalidomide Babies. (huffpost.com)
  • I'm lucky to have the arm down to the elbow-many thalidomide babies have only a bulbous lump at the shoulder-and I'm lucky to have my two fingers attached to the stump, though I know it's the fingers-thick and flipper-like, sprouting from an elbow-that upset people. (triquarterly.org)
  • It was one of epic tragedies of the mid-20th century: babies born without arms and legs, sometimes deaf or blind, sometimes with brain or heart damage - all because their mothers were nauseated or sleepless during their pregnancies and given Thalidomide to ease their symptoms. (flashbak.com)
  • is a film about Thalidomide, a drug made by Grünenthal which severely disabled thousands of babies in the 60's and caused the worst pharmaceutical scandal in history. (thalidomidestory.com)
  • The Kefauver-Harris Bill is passed to ensure greater drug safety in the United States after thalidomide (a new sleeping pill) is found to have caused birth defects in thousands of babies born in Western Europe. (calstatela.edu)
  • In November 1960 a German pharmacist wrote Grünenthal a letter asking if Thalidomide could cause malformations in unborn babies. (thalidomidestory.com)
  • The UK government gave survivors a grant of £20 million, to be distributed through the Thalidomide Trust, in December 2009. (wikipedia.org)
  • It's a disgrace that it's taken them 50 years to apologize,' said Astbury, of the Thalidomide U.K. agency, an advocacy group for survivors. (usmessageboard.com)
  • 31 Aug.`12 - Thalidomide survivors on Saturday rebuffed an apology by the German company that manufactured the drug, saying it was an 'insulting' response to the thousands born disabled as a result of its use. (usmessageboard.com)
  • We must maintain pressure on the German federal government to be open about what has gone on, and properly compensate thalidomide survivors," said Ms Evans. (bbc.co.uk)
  • I was attending World Federation of Jewish Child Survivors of the Holocaust and Descendants 24th Annual International Conference in Cleveland last week, when my aunt, herself a survivor, handed me a copy of Newsweek with a cover article, "The Nazis and Thalidomide: The Worst Drug Scandal of All Time. (scientificamerican.com)
  • All the UK survivors receive yearly disbursements from the Thalidomide Trust, which is funded by a settlement with Distillers Biochemicals, the company that distributed the drug in Britain. (benzo.org.uk)
  • The USA largely escaped the thalidomide tragedy - due to stronger regulations, and the action of a single employee. (sciencebasedmedicine.org)
  • The British state would also issue a public apology for its role in the tragedy. (benzo.org.uk)
  • In 2012 Gruenenthal Group (The company which sold Thalidomide) to mothers and their children for the tragedy. (germlineexposures.org)
  • Welsh people left disabled by the thalidomide drug scandal are being backed in their fight for compensation by Plaid Cymru MEP Jill Evans. (bbc.co.uk)
  • Stock spoke in the west German city of Stolberg, where the company is based, during the unveiling of a bronze statue symbolizing a child born without limbs because of thalidomide. (usmessageboard.com)
  • Last week The Sunday Times told how Veronica Pakenham, restricted to a wheelchair because all her limbs have been damaged by thalidomide and who has also suffered a stroke, had been told by a local health trust that she was not entitled to 24-hour care. (benzo.org.uk)
  • But the Thalidomide birth defects crisis put a new face on the dangers of modern pharmacology, revealing to the world that dangerous medicines could not only poison, but could alter humans' very structure, causing birth defects like shortened or missing limbs, heart defects, and damage to ears, eyes, and the brain. (litigationandtrial.com)
  • Thalidomide apology insulting, campaigners say BBC News 1 September 2012. (wikipedia.org)
  • Thalidomide, which came out on the German market late in the 1950s, had previously been safety tested on thousands of animals. (envirolink.org)
  • Not only was thalidomide widely prescribed in the 1950s, it was also considered so completely safe for use by pregnant women that it was sold over the counter and free samples were commonly distributed by doctors. (blogspot.com)
  • A woman born without arms or legs on Monday won the right to have the class action she is leading against the firms behind thalidomide, a sedative blamed for birth defects, proceed in Australia. (medicalxpress.com)
  • Thalidomide was marketed as the sedative that would alleviate morning sickness. (flashbak.com)
  • Thalidomide was first introduced as a mild sedative that was advertised as so safe it could be used freely by children and pregnant women, for whom it was also prescribed to alleviate the nausea and vomiting associated with morning sickness. (blogspot.com)
  • 1 Patented in 1954, thalidomide was initially approved as the first non-addicting, non-barbiturate sedative 2 and was used as a treatment for respiratory infections. (blogspot.com)
  • The Swiss pharmaceutical company Ciba first synthesized thalidomide as an anticonvulsant drug in 1953, but when it failed early laboratory studies for that use, its development was taken over by the German company Chemie Grünenthal, which introduced the drug as a mild sedative in 1956. (blogspot.com)
  • Court papers used in the case allege that the drug's makers were warned of birth defects some two years before thalidomide was withdrawn from the market. (medindia.net)
  • The German makers of thalidomide were warned of birth defects years before it was withdrawn and Australian distributors used pregnant women as the world's first test subjects, court papers alleged Friday. (medicalxpress.com)
  • He published a letter on the teratogenicity of thalidomide following the findings of a midwife called Pat Sparrow, which resulted in the reduction of the number of drugs prescribed during pregnancy. (wikipedia.org)
  • Bonnie's Blog With Bonnie & Steve Minsky: Makers of Thalidomide Apologize. (blogspot.com)
  • Makers of Thalidomide Apologize. (blogspot.com)
  • Billed as a "wonder drug" to cure everything from morning sickness to insomnia, thalidomide also caused blindness and malformed organs. (medindia.net)
  • Thalidomide was introduced in 1956 and was aggressively marketed by the German pharmaceutical company Chemie Grünenthal under the trade name Contergan as a medication for anxiety, trouble sleeping, "tension", and morning sickness. (wikipedia.org)
  • Times were ripe for the entry of a drug called thalidomide, one that promised to quell nerves, quash morning sickness and thwart miscarriages. (huffpost.com)
  • Thalidomide was given to pregnant women to combat morning sickness but led to a wave of birth defects in Europe, Australia, Canada, Japan and the U.S. Despite the words of contrition, the drug maker Gruenenthal has refused to settle lawsuits, the most recent involving class actions in Australia. (flashbak.com)
  • Thalidomide, which was aggressively marketed as a totally safe and effective treatment for morning sickness in early pregnancy, ultimately took its place as the drug that caused "the largest man ‐ made medical disaster in history. (blogspot.com)
  • Working with P H Huang, he proposed that thalidomide caused malformations by interacting with the DNA of the dividing embryonic cells. (wikipedia.org)
  • Thalidomide was never approved for use in pregnant women in the United States. (usmessageboard.com)
  • An April 21, 1969 photo from files showing a view of a laboratory of the pharmaceutical company "Chemie Gruenenthal", in Stolberg, near Aachen, West Germany, during an animal experiment April 21, 1969 as prosecuters came to inspect the manufacturer of the drug Thalidomide, which was prescribed by doctors as harmless sleeping drug to pregnant women and caused the miscarriage and birth of thousands of crippled children. (flashbak.com)
  • Thalidomide had never been tested on pregnant women or pregnant animals. (thalidomidestory.com)
  • It wasn't known at the time, but fetal exposure to thalidomide between days 35 and 48 was causing severe limb and organ defects in 20-30% of children. (sciencebasedmedicine.org)
  • Freddie Astbury, of Liverpool, England, was born without arms or legs after his mother took thalidomide. (usmessageboard.com)
  • Thalidomide did not damage the fetus if taken after 42 days' gestation. (wikipedia.org)
  • In Spain, thalidomide was widely available throughout the 1970s, and perhaps even into the 1980s. (wikipedia.org)
  • Last Friday, Gruenethal, the German pharmaceutical firm responsible for the drug, claimed to be making public apology for its sins a half-century ago, but it left out the most basic component of a genuine contrition: the admission of fault. (litigationandtrial.com)
  • The drug's UK manufacturer Distillers agreed in 1973 to pay more than £20m compensation to families affected, and in 2009 the then Labour UK government issued an apology and promised a further £20m compensation. (bbc.co.uk)
  • Journalist Geoff Adams-Spink, himself a victim of thalidomide, notes that Gruenthal hasn't promised any compensation along with its "apology. (litigationandtrial.com)
  • The birth defects of thalidomide led to the development of greater drug regulation and monitoring in many countries. (wikipedia.org)
  • They noted that no mechanism of action whatsoever had been offered by the prosecution to explain how thalidomide could cause birth defects. (ahrp.org)
  • The first medical expert for the plaintiffs was Dr. Widukind Lenz who had spent much of his professional career personally examining children in Germany, Belgium, England, Japan, and Sweden compiling information about thalidomide caused birth defects. (ahrp.org)
  • The broad strokes of thalidomide causing thousands of birth defects are well known. (sciencebasedmedicine.org)
  • First, the physical defects from Thalidomide were very apparent and immediate. (germlineexposures.org)
  • The birth defects caused by the drug thalidomide can range from moderate malformation to more severe forms. (mycupcakeworld.com)
  • The total number of people affected by the use of thalidomide during the mother's pregnancy is estimated at more than 10,000, of whom approximately 40 percent died at or shortly after the time of birth. (wikipedia.org)
  • Thalidomide was developed and first released by the German pharmaceutical company Chemie Grünenthal in 1957. (wikipedia.org)
  • A three-year-old girl, born without arms to a German mother who took the drug thalidomide, uses power-driven artificial arms fitted to her by Dr. Ernst Marquardt of the University of Heidelberg in Germany, 1965. (flashbak.com)
  • After several articles by renowned German neurologists were published in medical journals about Thalidomide and nerve damage, Grünenthal revised its package leaflet for Thalidomide and applied for the prescription-only status in select German federal states. (thalidomidestory.com)
  • An apology is a matter of course," said Tsugumichi Sato, director-general of "Ishizue" Thalidomide Welfare Center in Japan, one of the major countries affected by the drug disaster after Germany and Britain. (medindia.net)
  • The silver-lining of the Thalidomide disaster was, just like with Elixir sulfanilamide, improved regulation of pharmaceutical drugs. (litigationandtrial.com)
  • When you think about the largest or greatest drug disaster most people think of Thalidomide which was certainly a devastating catastrophe. (germlineexposures.org)
  • In 1997, Diageo (formed by a merger between Grand Metropolitan and Guinness, who had taken over Distillers in 1990) made a long-term financial commitment to support the Thalidomide Trust and its beneficiaries. (wikipedia.org)
  • The tranquilizers in direct competition with thalidomide were all tested for teratogenic effects and the results published. (litigationandtrial.com)
  • Last July, an Australian woman born without arms and legs after her mother took thalidomide reached a multimillion dollar settlement with the drug's British distributor. (medicalxpress.com)
  • Could this apology be preparing us for thalidomide's approval for some of these other conditions discussed in the piece? (blogspot.com)
  • The British Thalidomide Children's Trust was set up in 1973 as part of a £20 million legal settlement between Distillers Company and 429 children with thalidomide-related disabilities. (wikipedia.org)
  • The 52-year-old said the apology was years long overdue. (usmessageboard.com)
  • I have been reading mental health stuff for years and have never heard of an apology from the psycho pharma industry for any of the horrific stuff they have been busted for. (madinamerica.com)
  • Exactly 50 years ago today, Thalidomide was pulled off the market. (madinamerica.com)
  • It is 39 years since, as editor of the Sunday Times of London in the early seventies, I was associated with thalidomide investigations. (litigationandtrial.com)
  • Why is the drug manufacturer of Thalidomide apologizing 50 years later? (robertscottbell.com)
  • Judy Stone - From the Holocaust to Thalidomide: A Nazi Legacy - Christie Wilcox - Coral Recruits Goby Bodyguards Against Seaweed Assassins - Jason G. (scientificamerican.com)
  • Despite a track record of bringing us drugs that kill and maim, such as Vioxx, AZT, Fen Phen, and Thalidomide, there is never an apology, never a commitment to improve, never even an acknowledgement that they have done anything wrong. (offtheradar.co.nz)
  • One person's obsessive pursuit of the pharmaceutical industry is another person's brave campaign against thalidomide. (clubtroppo.com.au)
  • thalidomide taken on the 20th day of pregnancy caused central brain damage, day 21 would damage the eyes, day 22 the ears and face, day 24 the arms, and leg damage would occur if taken up to day 28. (wikipedia.org)
  • Dr. George James, acting New York City health commissioner, holds containers of the drug Thalidomide, blamed for recent births of deformed children. (flashbak.com)
  • His proposal involves paying about £8m a year to the Thalidomide Trust using personal health budgets boosted by money from central government. (benzo.org.uk)
  • That's when we learned that (a) they couldn't fill a Thalidomide prescription, which was just as well because (b) the nurse had written two prescriptions for Acyclovir and none for Thalidomide! (blogspot.com)
  • Long story short, we scrambled to get a prescription for Thalidomide from Caleb (BB's physician's assistant) and he found a Walgreen's that would ship it overnight, so that arrives tomorrow, allegedly. (blogspot.com)
  • Meridia 10mg online uk pharmacy According sibutramine 15mg prescription directions to Mangum, the women were coaxed back into the house with an apology, at which point they were separated. (logcabinleatherbyjan.com)
  • The severity and type of defect could be related to the timing of exposure through disrupting organ formation, as demonstrated for thalidomide . (theconversation.com)
  • Thalidomide became a popular drug because of its apparent safety and effectiveness, and it was marketed alone and in combination with other drugs in Germany, the UK, Canada, and other countries. (sciencebasedmedicine.org)
  • We are closely watching what responsibility the company will take on top of apologies. (medindia.net)
  • Accessed 31 March 2017 https://www.abc.net.au/news/health/2018-06-29/thalidomide-william-mcbride-flawed-character-norman-swan/9920608 ABC News Dayton, Leigh (26 February 2019). (wikipedia.org)
  • The Department of Health said: "Everyone has the greatest sympathy for patients and families affected by thalidomide. (benzo.org.uk)
  • To date, no apology has been made by either Kardashian or Duchesnay for violating FDA rules and for potentially duping millions of future consumers of Diclegis. (blogspot.com)
  • Unrecognized at the time, the first "thalidomide baby" was born to a Chemie Grünenthal employee that same year. (blogspot.com)
  • Next we have the fact that Thalidomide was not distributed worldwide so the number of people exposed was far less. (germlineexposures.org)
  • Corrine Vandeput, a child born with thalidomide damage was given a lethal dose of barbituate by her mother Suzanne Vandeput. (flashbak.com)