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Apolipoproteins CApolipoproteinsApolipoproteins AApolipoproteins BApolipoprotein A-IApolipoprotein A-IIApolipoproteins EApolipoprotein C-IIApolipoprotein C-IIILipoproteins, HDLApolipoproteins DLipoproteinsApolipoprotein C-ICholesterolLipoproteins, VLDLTriglyceridesLipidsApolipoprotein B-100Apolipoprotein B-48Cholesterol, HDLLipoproteins, HDL3Tangier DiseasePhosphatidylcholine-Sterol O-AcyltransferaseLipoproteins, LDLNephelometry and TurbidimetryATP Binding Cassette Transporter 1Cholesterol EstersIsoelectric FocusingReceptors, LipoproteinLipid MetabolismChylomicronsCholesterol, LDLPhospholipidsUltracentrifugationHypolipoproteinemiasLipoproteins, HDL2Lipoprotein(a)LymphElectrophoresis, Polyacrylamide GelApoproteinsHyperlipidemiasLiverImmunodiffusionLipoprotein LipaseTrioleinHyperlipoproteinemia Type IVPhosphatidylcholinesKineticsATP-Binding Cassette TransportersHyperlipoproteinemiasApolipoprotein E3Chemistry, ClinicalCholesterol, VLDLHypertriglyceridemiaCholesterol Ester Transfer ProteinsLipoproteins, IDLReference ValuesScavenger Receptors, Class BFreeze DryingEthinyl EstradiolParticle SizeImmunoassaySerum Amyloid A ProteinDietary FatsMicroscopy, ElectronImmunoelectrophoresisHyperlipoproteinemia Type VAbetalipoproteinemiaDimyristoylphosphatidylcholineReceptors, ScavengerAmino Acid SequenceOleic AcidChromatography, GelMolecular WeightArteriosclerosisBiological TransportLipolysisSterol O-AcyltransferaseRats, Inbred StrainsCallitrichinaeHigh-Density Lipoproteins, Pre-betaLipaseLiposomesReceptors, LDLOleic AcidsCarrier ProteinsMolecular Sequence DataLecithin Acyltransferase DeficiencyHyperlipidemia, Familial CombinedProtein BindingAntigens, CD36ButterHyperlipoproteinemia Type IIEsterificationGlycoproteinsEmulsionsSalmonidaeBinding, Competitive
Apolipoproteins C: A group of apolipoproteins that can readily exchange among the various classes of lipoproteins (HDL; VLDL; CHYLOMICRONS). After lipolysis of TRIGLYCERIDES on VLDL and chylomicrons, Apo-C proteins are normally transferred to HDL. The subtypes can modulate remnant binding to receptors, LECITHIN CHOLESTEROL ACYLTRANSFERASE, or LIPOPROTEIN LIPASE.Apolipoproteins: Protein components on the surface of LIPOPROTEINS. They form a layer surrounding the hydrophobic lipid core. There are several classes of apolipoproteins with each playing a different role in lipid transport and LIPID METABOLISM. These proteins are synthesized mainly in the LIVER and the INTESTINES.Apolipoproteins A: Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.Apolipoproteins B: Major structural proteins of triacylglycerol-rich LIPOPROTEINS. There are two forms, apolipoprotein B-100 and apolipoprotein B-48, both derived from a single gene. ApoB-100 expressed in the liver is found in low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). ApoB-48 expressed in the intestine is found in CHYLOMICRONS. They are important in the biosynthesis, transport, and metabolism of triacylglycerol-rich lipoproteins. Plasma Apo-B levels are high in atherosclerotic patients but non-detectable in ABETALIPOPROTEINEMIA.Apolipoprotein A-I: The most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. This protein serves as an acceptor for CHOLESTEROL released from cells thus promoting efflux of cholesterol to HDL then to the LIVER for excretion from the body (reverse cholesterol transport). It also acts as a cofactor for LECITHIN CHOLESTEROL ACYLTRANSFERASE that forms CHOLESTEROL ESTERS on the HDL particles. Mutations of this gene APOA1 cause HDL deficiency, such as in FAMILIAL ALPHA LIPOPROTEIN DEFICIENCY DISEASE and in some patients with TANGIER DISEASE.Apolipoprotein A-II: The second most abundant protein component of HIGH DENSITY LIPOPROTEINS or HDL. It has a high lipid affinity and is known to displace APOLIPOPROTEIN A-I from HDL particles and generates a stable HDL complex. ApoA-II can modulate the activation of LECITHIN CHOLESTEROL ACYLTRANSFERASE in the presence of APOLIPOPROTEIN A-I, thus affecting HDL metabolism.Apolipoproteins E: A class of protein components which can be found in several lipoproteins including HIGH-DENSITY LIPOPROTEINS; VERY-LOW-DENSITY LIPOPROTEINS; and CHYLOMICRONS. Synthesized in most organs, Apo E is important in the global transport of lipids and cholesterol throughout the body. Apo E is also a ligand for LDL receptors (RECEPTORS, LDL) that mediates the binding, internalization, and catabolism of lipoprotein particles in cells. There are several allelic isoforms (such as E2, E3, and E4). Deficiency or defects in Apo E are causes of HYPERLIPOPROTEINEMIA TYPE III.Apolipoprotein C-II: A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS. It contains a cofactor for LIPOPROTEIN LIPASE and activates several triacylglycerol lipases. The association of Apo C-II with plasma CHYLOMICRONS; VLDL, and HIGH-DENSITY LIPOPROTEINS is reversible and changes rapidly as a function of triglyceride metabolism. Clinically, Apo C-II deficiency is similar to lipoprotein lipase deficiency (HYPERLIPOPROTEINEMIA TYPE I) and is therefore called hyperlipoproteinemia type IB.Apolipoprotein C-III: A 9-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS and CHYLOMICRON REMNANTS. Apo C-III, synthesized in the liver, is an inhibitor of LIPOPROTEIN LIPASE. Apo C-III modulates the binding of chylomicron remnants and VLDL to receptors (RECEPTORS, LDL) thus decreases the uptake of triglyceride-rich particles by the liver cells and subsequent degradation. The normal Apo C-III is glycosylated. There are several polymorphic forms with varying amounts of SIALIC ACID (Apo C-III-0, Apo C-III-1, and Apo C-III-2).Lipoproteins, HDL: A class of lipoproteins of small size (4-13 nm) and dense (greater than 1.063 g/ml) particles. HDL lipoproteins, synthesized in the liver without a lipid core, accumulate cholesterol esters from peripheral tissues and transport them to the liver for re-utilization or elimination from the body (the reverse cholesterol transport). Their major protein component is APOLIPOPROTEIN A-I. HDL also shuttle APOLIPOPROTEINS C and APOLIPOPROTEINS E to and from triglyceride-rich lipoproteins during their catabolism. HDL plasma level has been inversely correlated with the risk of cardiovascular diseases.Apolipoproteins D: A glycoprotein component of HIGH-DENSITY LIPOPROTEINS that transports small hydrophobic ligands including CHOLESTEROL and STEROLS. It occurs in the macromolecular complex with LECITHIN CHOLESTEROL ACYLTRANSFERASE. Apo D is expressed in and secreted from a variety of tissues such as liver, placenta, brain tissue and others.Lipoproteins: Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes.Apolipoprotein C-I: A 6.6-kDa protein component of VERY-LOW-DENSITY LIPOPROTEINS; INTERMEDIATE-DENSITY LIPOPROTEINS; and HIGH-DENSITY LIPOPROTEINS. Apo C-I displaces APO E from lipoproteins, modulate their binding to receptors (RECEPTORS, LDL), and thereby decrease their clearance from plasma. Elevated Apo C-I levels are associated with HYPERLIPOPROTEINEMIA and ATHEROSCLEROSIS.Cholesterol: The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.Lipoproteins, VLDL: A class of lipoproteins of very light (0.93-1.006 g/ml) large size (30-80 nm) particles with a core composed mainly of TRIGLYCERIDES and a surface monolayer of PHOSPHOLIPIDS and CHOLESTEROL into which are imbedded the apolipoproteins B, E, and C. VLDL facilitates the transport of endogenously made triglycerides to extrahepatic tissues. As triglycerides and Apo C are removed, VLDL is converted to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LOW-DENSITY LIPOPROTEINS from which cholesterol is delivered to the extrahepatic tissues.TriglyceridesLipids: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)Apolipoprotein B-100: A 513-kDa protein synthesized in the LIVER. It serves as the major structural protein of low-density lipoproteins (LIPOPROTEINS, LDL; LIPOPROTEINS, VLDL). It is the ligand for the LDL receptor (RECEPTORS, LDL) that promotes cellular binding and internalization of LDL particles.Apolipoprotein B-48: A 241-kDa protein synthesized only in the INTESTINES. It serves as a structural protein of CHYLOMICRONS. Its exclusive association with chylomicron particles provides an indicator of intestinally derived lipoproteins in circulation. Apo B-48 is a shortened form of apo B-100 and lacks the LDL-receptor region.Cholesterol, HDL: Cholesterol which is contained in or bound to high-density lipoproteins (HDL), including CHOLESTEROL ESTERS and free cholesterol.Lipoproteins, HDL3: Intermediate-density subclass of the high-density lipoproteins, with particle sizes between 7 to 8 nm. As the larger lighter HDL2 lipoprotein, HDL3 lipoprotein is lipid-rich.Tangier Disease: An autosomal recessively inherited disorder caused by mutation of ATP-BINDING CASSETTE TRANSPORTERS involved in cellular cholesterol removal (reverse-cholesterol transport). It is characterized by near absence of ALPHA-LIPOPROTEINS (high-density lipoproteins) in blood. The massive tissue deposition of cholesterol esters results in HEPATOMEGALY; SPLENOMEGALY; RETINITIS PIGMENTOSA; large orange tonsils; and often sensory POLYNEUROPATHY. The disorder was first found among inhabitants of Tangier Island in the Chesapeake Bay, MD.Phosphatidylcholine-Sterol O-Acyltransferase: An enzyme secreted from the liver into the plasma of many mammalian species. It catalyzes the esterification of the hydroxyl group of lipoprotein cholesterol by the transfer of a fatty acid from the C-2 position of lecithin. In familial lecithin:cholesterol acyltransferase deficiency disease, the absence of the enzyme results in an excess of unesterified cholesterol in plasma. EC 2.3.1.43.Lipoproteins, LDL: A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues.Nephelometry and Turbidimetry: Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.ATP Binding Cassette Transporter 1: A superfamily of large integral ATP-binding cassette membrane proteins whose expression pattern is consistent with a role in lipid (cholesterol) efflux. It is implicated in TANGIER DISEASE characterized by accumulation of cholesteryl ester in various tissues.Cholesterol Esters: Fatty acid esters of cholesterol which constitute about two-thirds of the cholesterol in the plasma. The accumulation of cholesterol esters in the arterial intima is a characteristic feature of atherosclerosis.Isoelectric Focusing: Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.Receptors, Lipoprotein: Cell surface proteins that bind lipoproteins with high affinity. Lipoprotein receptors in the liver and peripheral tissues mediate the regulation of plasma and cellular cholesterol metabolism and concentration. The receptors generally recognize the apolipoproteins of the lipoprotein complex, and binding is often a trigger for endocytosis.Lipid Metabolism: Physiological processes in biosynthesis (anabolism) and degradation (catabolism) of LIPIDS.Chylomicrons: A class of lipoproteins that carry dietary CHOLESTEROL and TRIGLYCERIDES from the SMALL INTESTINE to the tissues. Their density (0.93-1.006 g/ml) is the same as that of VERY-LOW-DENSITY LIPOPROTEINS.Cholesterol, LDL: Cholesterol which is contained in or bound to low density lipoproteins (LDL), including CHOLESTEROL ESTERS and free cholesterol.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Ultracentrifugation: Centrifugation with a centrifuge that develops centrifugal fields of more than 100,000 times gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Hypolipoproteinemias: Conditions with abnormally low levels of LIPOPROTEINS in the blood. This may involve any of the lipoprotein subclasses, including ALPHA-LIPOPROTEINS (high-density lipoproteins); BETA-LIPOPROTEINS (low-density lipoproteins); and PREBETA-LIPOPROTEINS (very-low-density lipoproteins).Lipoproteins, HDL2: Low-density subclass of the high-density lipoproteins, with particle sizes between 8 to 13 nm.Lipoprotein(a): A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.Lymph: The interstitial fluid that is in the LYMPHATIC SYSTEM.Electrophoresis, Polyacrylamide Gel: Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.Apoproteins: The protein components of a number of complexes, such as enzymes (APOENZYMES), ferritin (APOFERRITINS), or lipoproteins (APOLIPOPROTEINS).Hyperlipidemias: Conditions with excess LIPIDS in the blood.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Immunodiffusion: Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.Lipoprotein Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. The enzyme hydrolyzes triacylglycerols in chylomicrons, very-low-density lipoproteins, low-density lipoproteins, and diacylglycerols. It occurs on capillary endothelial surfaces, especially in mammary, muscle, and adipose tissue. Genetic deficiency of the enzyme causes familial hyperlipoproteinemia Type I. (Dorland, 27th ed) EC 3.1.1.34.Triolein: (Z)-9-Octadecenoic acid 1,2,3-propanetriyl ester.Hyperlipoproteinemia Type IV: A hypertriglyceridemia disorder, often with autosomal dominant inheritance. It is characterized by the persistent elevations of plasma TRIGLYCERIDES, endogenously synthesized and contained predominantly in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins). In contrast, the plasma CHOLESTEROL and PHOSPHOLIPIDS usually remain within normal limits.Phosphatidylcholines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.Kinetics: The rate dynamics in chemical or physical systems.ATP-Binding Cassette Transporters: A family of MEMBRANE TRANSPORT PROTEINS that require ATP hydrolysis for the transport of substrates across membranes. The protein family derives its name from the ATP-binding domain found on the protein.Hyperlipoproteinemias: Conditions with abnormally elevated levels of LIPOPROTEINS in the blood. They may be inherited, acquired, primary, or secondary. Hyperlipoproteinemias are classified according to the pattern of lipoproteins on electrophoresis or ultracentrifugation.Apolipoprotein E3: A 34-kDa glycosylated protein. A major and most common isoform of apolipoprotein E. Therefore, it is also known as apolipoprotein E (ApoE). In human, Apo E3 is a 299-amino acid protein with a cysteine at the 112 and an arginine at the 158 position. It is involved with the transport of TRIGLYCERIDES; PHOSPHOLIPIDS; CHOLESTEROL; and CHOLESTERYL ESTERS in and out of the cells.Chemistry, Clinical: The specialty of ANALYTIC CHEMISTRY applied to assays of physiologically important substances found in blood, urine, tissues, and other biological fluids for the purpose of aiding the physician in making a diagnosis or following therapy.Cholesterol, VLDL: Cholesterol which is contained in or bound to very low density lipoproteins (VLDL). High circulating levels of VLDL cholesterol are found in HYPERLIPOPROTEINEMIA TYPE IIB. The cholesterol on the VLDL is eventually delivered by LOW-DENSITY LIPOPROTEINS to the tissues after the catabolism of VLDL to INTERMEDIATE-DENSITY LIPOPROTEINS, then to LDL.Hypertriglyceridemia: A condition of elevated levels of TRIGLYCERIDES in the blood.Cholesterol Ester Transfer Proteins: Proteins that bind to and transfer CHOLESTEROL ESTERS between LIPOPROTEINS such as LOW-DENSITY LIPOPROTEINS and HIGH-DENSITY LIPOPROTEINS.Lipoproteins, IDL: A mixture of very-low-density lipoproteins (VLDL), particularly the triglyceride-poor VLDL, with slow diffuse electrophoretic mobilities in the beta and alpha2 regions which are similar to that of beta-lipoproteins (LDL) or alpha-lipoproteins (HDL). They can be intermediate (remnant) lipoproteins in the de-lipidation process, or remnants of mutant CHYLOMICRONS and VERY-LOW-DENSITY LIPOPROTEINS which cannot be metabolized completely as seen in FAMILIAL DYSBETALIPOPROTEINEMIA.Reference Values: The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.Scavenger Receptors, Class B: A family of scavenger receptors that are predominately localized to CAVEOLAE of the PLASMA MEMBRANE and bind HIGH DENSITY LIPOPROTEINS.Freeze Drying: Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.Ethinyl Estradiol: A semisynthetic alkylated ESTRADIOL with a 17-alpha-ethinyl substitution. It has high estrogenic potency when administered orally, and is often used as the estrogenic component in ORAL CONTRACEPTIVES.Particle Size: Relating to the size of solids.Immunoassay: A technique using antibodies for identifying or quantifying a substance. Usually the substance being studied serves as antigen both in antibody production and in measurement of antibody by the test substance.Serum Amyloid A Protein: An ACUTE PHASE REACTION protein present in low concentrations in normal sera, but found at higher concentrations in sera of older persons and in patients with AMYLOIDOSIS. It is the circulating precusor of amyloid A protein, which is found deposited in AA type AMYLOID FIBRILS.Dietary Fats: Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.Microscopy, Electron: Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.Immunoelectrophoresis: A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.Hyperlipoproteinemia Type V: A severe type of hyperlipidemia, sometimes familial, that is characterized by the elevation of both plasma CHYLOMICRONS and TRIGLYCERIDES contained in VERY-LOW-DENSITY LIPOPROTEINS. Type V hyperlipoproteinemia is often associated with DIABETES MELLITUS and is not caused by reduced LIPOPROTEIN LIPASE activity as in HYPERLIPOPROTEINEMIA TYPE I .Abetalipoproteinemia: An autosomal recessive disorder of lipid metabolism. It is caused by mutation of the microsomal triglyceride transfer protein that catalyzes the transport of lipids (TRIGLYCERIDES; CHOLESTEROL ESTERS; PHOSPHOLIPIDS) and is required in the secretion of BETA-LIPOPROTEINS (low density lipoproteins or LDL). Features include defective intestinal lipid absorption, very low serum cholesterol level, and near absent LDL.Dimyristoylphosphatidylcholine: A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.Receptors, Scavenger: A large group of structurally diverse cell surface receptors that mediate endocytic uptake of modified LIPOPROTEINS. Scavenger receptors are expressed by MYELOID CELLS and some ENDOTHELIAL CELLS, and were originally characterized based on their ability to bind acetylated LOW-DENSITY LIPOPROTEINS. They can also bind a variety of other polyanionic ligand. Certain scavenger receptors can internalize micro-organisms as well as apoptotic cells.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Oleic Acid: An unsaturated fatty acid that is the most widely distributed and abundant fatty acid in nature. It is used commercially in the preparation of oleates and lotions, and as a pharmaceutical solvent. (Stedman, 26th ed)Chromatography, Gel: Chromatography on non-ionic gels without regard to the mechanism of solute discrimination.Molecular Weight: The sum of the weight of all the atoms in a molecule.Arteriosclerosis: Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.Biological Transport: The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.Lipolysis: The metabolic process of breaking down LIPIDS to release FREE FATTY ACIDS, the major oxidative fuel for the body. Lipolysis may involve dietary lipids in the DIGESTIVE TRACT, circulating lipids in the BLOOD, and stored lipids in the ADIPOSE TISSUE or the LIVER. A number of enzymes are involved in such lipid hydrolysis, such as LIPASE and LIPOPROTEIN LIPASE from various tissues.Sterol O-Acyltransferase: An enzyme that catalyzes the formation of cholesterol esters by the direct transfer of the fatty acid group from a fatty acyl CoA derivative. This enzyme has been found in the adrenal gland, gonads, liver, intestinal mucosa, and aorta of many mammalian species. EC 2.3.1.26.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Callitrichinae: A subfamily in the family CEBIDAE that consists of four genera: CALLITHRIX (marmosets), CALLIMICO (Goeldi's monkey), LEONTOPITHECUS (lion tamarins), and SAGUINUS (long-tusked tamarins). The members of this family inhabit the tropical forests of South and Central America.High-Density Lipoproteins, Pre-beta: A highly dense subclass of the high-density lipoproteins, with particle sizes below 7 nm. They are also known as nascent HDL, composed of a few APOLIPOPROTEIN A-I molecules which are complexed with PHOSPHOLIPIDS. The lipid-poor pre-beta-HDL particles serve as progenitors of HDL3 and then HDL2 after absorption of free cholesterol from cell membranes, cholesterol esterification, and acquisition of apolipoproteins A-II, Cs, and E. Pre-beta-HDL initiate the reverse cholesterol transport process from cells to liver.Lipase: An enzyme of the hydrolase class that catalyzes the reaction of triacylglycerol and water to yield diacylglycerol and a fatty acid anion. It is produced by glands on the tongue and by the pancreas and initiates the digestion of dietary fats. (From Dorland, 27th ed) EC 3.1.1.3.Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Receptors, LDL: Receptors on the plasma membrane of nonhepatic cells that specifically bind LDL. The receptors are localized in specialized regions called coated pits. Hypercholesteremia is caused by an allelic genetic defect of three types: 1, receptors do not bind to LDL; 2, there is reduced binding of LDL; and 3, there is normal binding but no internalization of LDL. In consequence, entry of cholesterol esters into the cell is impaired and the intracellular feedback by cholesterol on 3-hydroxy-3-methylglutaryl CoA reductase is lacking.Oleic Acids: A group of fatty acids that contain 18 carbon atoms and a double bond at the omega 9 carbon.Carrier Proteins: Transport proteins that carry specific substances in the blood or across cell membranes.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Lecithin Acyltransferase Deficiency: An autosomal recessively inherited disorder caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE that facilitates the esterification of lipoprotein cholesterol and subsequent removal from peripheral tissues to the liver. This defect results in low HDL-cholesterol level in blood and accumulation of free cholesterol in tissue leading to a triad of CORNEAL OPACITY, hemolytic anemia (ANEMIA, HEMOLYTIC), and PROTEINURIA.Hyperlipidemia, Familial Combined: A type of familial lipid metabolism disorder characterized by a variable pattern of elevated plasma CHOLESTEROL and/or TRIGLYCERIDES. Multiple genes on different chromosomes may be involved, such as the major late transcription factor (UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Antigens, CD36: Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.Butter: The fatty portion of milk, separated as a soft yellowish solid when milk or cream is churned. It is processed for cooking and table use. (Random House Unabridged Dictionary, 2d ed)Hyperlipoproteinemia Type II: A group of familial disorders characterized by elevated circulating cholesterol contained in either LOW-DENSITY LIPOPROTEINS alone or also in VERY-LOW-DENSITY LIPOPROTEINS (pre-beta lipoproteins).Esterification: The process of converting an acid into an alkyl or aryl derivative. Most frequently the process consists of the reaction of an acid with an alcohol in the presence of a trace of mineral acid as catalyst or the reaction of an acyl chloride with an alcohol. Esterification can also be accomplished by enzymatic processes.Glycoproteins: Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.Emulsions: Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.Salmonidae: A family of anadromous fish comprising SALMON; TROUT; whitefish; and graylings. They are the most important food and game fishes. Their habitat is the northern Atlantic and Pacific, both marine and inland, and the Great Lakes. (Nelson: Fishes of the World, 1976, p97)Binding, Competitive: The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.

Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor. (1/546)

We have shown previously that human apolipoprotein (apo)C1 transgenic mice exhibit hyperlipidaemia, due primarily to an impaired clearance of very-low-density lipoprotein (VLDL) particles from the circulation. In the absence of at least the low-density-lipoprotein receptor (LDLR), it was shown that APOC1 overexpression in transgenic mice inhibited the hepatic uptake of VLDL via the LDLR-related protein. In the present study, we have now examined the effect of apoC1 on the binding of lipoproteins to both the VLDL receptor (VLDLR) and the LDLR. The binding specificity of the VLDLR and LDLR for apoC1-enriched lipoprotein particles was examined in vivo through adenovirus-mediated gene transfer of the VLDLR and the LDLR [giving rise to adenovirus-containing (Ad)-VLDLR and Ad-LDLR respectively] in APOC1 transgenic mice, LDLR-deficient (LDLR-/-) mice and wild-type mice. Remarkably, Ad-VLDLR treatment did not reduce hyperlipidaemia in transgenic mice overexpressing human APOC1, irrespective of both the level of transgenic expression and the presence of the LDLR, whereas Ad-VLDLR treatment did reverse hyperlipidaemia in LDLR-/- and wild-type mice. On the other hand, Ad-LDLR treatment strongly decreased plasma lipid levels in these APOC1 transgenic mice. These results suggest that apoC1 inhibits the clearance of lipoprotein particles via the VLDLR, but not via the LDLR. This hypothesis is corroborated by in vitro binding studies. Chinese hamster ovary (CHO) cells expressing the VLDLR (CHO-VLDLR) or LDLR (CHO-LDLR) bound less APOC1 transgenic VLDL than wild-type VLDL. Intriguingly, however, enrichment with apoE enhanced dose-dependently the binding of wild-type VLDL to CHO-VLDLR cells (up to 5-fold), whereas apoE did not enhance the binding of APOC1 transgenic VLDL to these cells. In contrast, for binding to CHO-LDLR cells, both wild-type and APOC1 transgenic VLDL were stimulated upon enrichment with apoE. From these studies, we conclude that apoC1 specifically inhibits the apoE-mediated binding of triacylglycerol-rich lipoprotein particles to the VLDLR, whereas apoC1-enriched lipoproteins can still bind to the LDLR. The variability in specificity of these lipoprotein receptors for apoC1-containing lipoprotein particles provides further evidence for a regulatory role of apoC1 in the delivery of lipoprotein constituents to different tissues on which these receptors are located.  (+info)

Allele-specific differences in apolipoprotein C-III mRNA expression in human liver. (2/546)

BACKGROUND: Sequence variations at the apolipoprotein (apo)C-III gene locus have been associated with increased plasma triglycerides. In particular, the S2 allele of an SstI polymorphism in the 3' untranslated region has been associated with hypertriglyceridemia in many populations. The aim of this study was to determine whether the variant S2 allele is related to increased mRNA expression in vivo. METHODS: We measured allele-specific apoC-III expression in liver biopsies of five obese subjects, using restriction isotyping and a primer extension method, both based on the SstI polymorphism. RESULTS: The expression of mRNA by the S1 and S2 alleles was similar in two patients, whereas the mRNA encoded by the S2 allele was 14%, 26%, and 29% more abundant than the wild-type mRNA in the remaining three patients. Because other polymorphisms at the apoC-III gene locus have been implicated in the S2-associated hypertriglyceridemia, we determined apoC-III haplotypes comprising promoter polymorphisms at -935, -641, -630, -625, -482, -455, as well as the SstI sites and a BbvI site, both located in the 3' untranslated region. None of these polymorphisms nor any haplotype exhibited a perfect association with allele-specific expression, but variation at the T-482C site correlated in four of five subjects with the relative allele abundance. CONCLUSION: These data provide preliminary evidence for allele-specific differences in apoC-III mRNA expression in vivo and suggest that such differences may contribute to associations of apoC-III gene polymorphisms with hypertriglyceridemia.  (+info)

Vitamin A is linked to the expression of the AI-CIII-AIV gene cluster in familial combined hyperlipidemia. (3/546)

There is growing evidence of the capacity of vitamin A to regulate the expression of the genetic region that encodes apolipoproteins (apo) A-I, C-III, and A-IV. This region in turn has been proposed to modulate the expression of hyperlipidemia in the commonest genetic form of dyslipidemia, familial combined hyperlipidemia (FCHL). The hypothesis tested here was whether vitamin A (retinol), by controlling the expression of the AI-CIII-AIV gene cluster, plays a role in modulating the hyperlipidemic phenotype in FCHL. We approached the subject by studying three genetic variants of this region: a C1100-T transition in exon 3 of the apoC-III gene, a G3206-T transversion in exon 4 of the apoC-III gene, and a G-75-A substitution in the promoter region of the apoA-I gene. The association between plasma vitamin A concentrations and differences in the plasma concentrations of apolipoproteins A-I and C-III based on the different genotypes was assessed in 48 FCHL patients and 74 of their normolipidemic relatives. The results indicated that the subjects carrying genetic variants associated with increased concentrations of apoA-I and C-III (C1100-T and G-75-A) also presented increased plasma concentrations of vitamin A. This was only observed among the FCHL patients, which suggested that certain characteristics of these patients contributed to this association. The G3206-T was not associated with changes in either apolipoprotein concentrations or in vitamin A. In summary, we report a relationship between genetically determined elevations of proteins of the AI-CIII-AIV gene cluster and vitamin A in FCHL patients. More studies will be needed to confirm that vitamin A plays a role in FCHL which might also be important for its potential application to therapeutical approaches.  (+info)

Mass spectral study of polymorphism of the apolipoproteins of very low density lipoprotein. (4/546)

New isoforms of apolipoprotein (apo)C-I and apoC-III have been detected in delipidated fractions from very low density lipoprotein (VLDL) using matrix-assisted laser desorption (MALDI) and electrospray ionization (ESI) mass spectrometry (MS). The cleavage sites of truncated apoC-III isoforms have also been identified. The VLDL fractions were isolated by fixed-angle single-spin ultracentrifugation using a self-generating sucrose density gradient and delipidated using a newly developed C18 solid phase extraction protocol. Fifteen apoC isoforms and apoE were identified in the MALDI spectra and the existence of the more abundant species was verified by ESI-MS. The relative intensities of the apoCs are closely correlated in three normolipidemic subjects. A fourth subject with type V hyperlipidemia exhibited an elevated apoC-III level and a suppressed level of the newly discovered truncated apoC-I isoform. ApoC-II was found to be particularly sensitive to in vitro oxidation. The dynamic range and specificity of the MALDI assay shows that the complete apoC isoform profile and apoE phenotype can be obtained in a single measurement from the delipidated VLDL fraction.  (+info)

Kinetics and mechanism of exchange of apolipoprotein C-III molecules from very low density lipoprotein particles. (5/546)

Transfer of apolipoprotein (apo) molecules between lipoprotein particles is an important factor in modulating the metabolism of the particles. Although the phenomenon is well established, the kinetics and molecular mechanism of passive apo exchange/transfer have not been defined in detail. In this study, the kinetic parameters governing the movement of radiolabeled apoC molecules from human very low density lipoprotein (VLDL) to high density lipoprotein (HDL3) particles were measured using a manganese phosphate precipitation assay to rapidly separate the two types of lipoprotein particles. In the case of VLDL labeled with human [14C]apoCIII1, a large fraction of the apoCIII1 transfers to HDL3 within 1 minute of mixing the two lipoproteins at either 4 degrees or 37 degrees C. As the diameter of the VLDL donor particles is decreased from 42-59 to 23-25 nm, the size of this rapidly transferring apoCIII1 pool increases from about 50% to 85%. There is also a pool of apoCIII1 existing on the donor VLDL particles that transfers more slowly. This slow transfer follows a monoexponential rate equation; for 35-40 nm donor VLDL particles the pool size is approximately 20% and the t1/2 is approximately 3 h. The flux of apoCIII molecules between VLDL and HDL3 is bidirectional and all of the apoCIII seems to be available for exchange so that equilibrium is attained. It is likely that the two kinetic pools of apoCIII are related to conformational variations of individual apo molecules on the surface of VLDL particles. The rate of slow transfer of apoCIII1 from donor VLDL (35-40 nm) to acceptor HDL3 is unaffected by an increase in the acceptor to donor ratio, indicating that the transfer is not dependent on collisions between donor and acceptor particles. Consistent with this, apoCIII1 molecules can transfer from donor VLDL to acceptor HDL3 particles across a 50 kDa molecular mass cutoff semipermeable membrane separating the lipoprotein particles. These results indicate that apoC molecules transfer between VLDL and HDL3 particles by an aqueous diffusion mechanism.  (+info)

CREB-binding protein is a transcriptional coactivator for hepatocyte nuclear factor-4 and enhances apolipoprotein gene expression. (6/546)

Hepatocyte nuclear factor-4 (HNF-4) is a liver-enriched transcription factor that is crucial in the regulation of a large number of genes involved in glucose, cholesterol, and fatty acid metabolism and in determining the hepatic phenotype. We have previously shown that HNF-4 contains transcription activation functions at the N terminus (AF-1) and the C terminus (AF-2) which work synergistically to confer full HNF-4 activity. Here, we show that HNF-4 recruits the CREB-binding protein (CBP) coactivator on promoters of genes that contain functional HNF-4 sites. HNF-4 interacts with the N-terminal region of CBP (amino acids 1-771) and the C-terminal region of CBP (amino acids 1812-2441). The two activating functions of HNF-4, AF-1 and AF-2, interact with the N terminus and the N and C terminus of CBP, respectively. In addition, we show that in contrast to the other nuclear hormone receptors the interaction between HNF-4 and CBP is ligand-independent. Recruitment of CBP by HNF-4 results in an enhancement of the transcriptional activity of the latter. CBP does not activate gene expression in the absence of HNF-4, and dominant negative forms of HNF-4 prevent transcriptional activation by CBP, suggesting that the mere recruitment of CBP by HNF-4 is not sufficient for enhancement of gene expression. These findings demonstrate that CBP acts as a transcriptional coactivator for HNF-4 and provide new insights into the regulatory function of HNF-4.  (+info)

Characterization of remnant-like particles isolated by immunoaffinity gel from the plasma of type III and type IV hyperlipoproteinemic patients. (7/546)

Previous studies have investigated the potential atherogenicity and thrombogenicity of triglyceride-rich lipoprotein (TRL) remnants by isolating them from plasma within a remnant-like particle (RLP) fraction, using an immunoaffinity gel containing specific anti-apoB-100 and anti-apoA-I antibodies. In order to characterize lipoproteins in this RLP fraction and to determine to what extent their composition varies from one individual to another, we have used automated gel filtration chromatography to determine the size heterogeneity of RLP isolated from normolipidemic control subjects (n = 8), and from type III (n = 6) and type IV (n = 9) hyperlipoproteinemic patients, who by selection had similarly elevated levels of plasma triglyceride (406 +/- 43 and 397 +/- 35 mg/dl, respectively). Plasma RLP triglyceride, cholesterol, apoB, apoC-III, and apoE concentrations were elevated 2- to 6-fold (P < 0. 05) in hyperlipoproteinemic patients compared to controls. RLP fractions of type III patients were enriched in cholesterol and apoE compared to those of type IV patients, and RLP of type IV patients were enriched in triglyceride and apoC-III relative to those of normolipidemic subjects. In normolipidemic subjects, the majority of RLP had a size similar to LDL or HDL. The RLP of hyperlipoproteinemic patients were, however, larger and were similar in size to TRL, or were intermediate in size (i.e., ISL) between that of TRL and LDL. Compared to controls, ISL in the RLP fraction of type III patients were enriched in apoE relative to apoC-III, whereas in type IV patients they were enriched in apoC-III relative to apoE. These results demonstrate that: 1) RLP are heterogeneous in size and composition in both normolipidemic and hypertriglyceridemic subjects, and 2) the apoE and apoC-III composition of RLP is different in type III compared to type IV hyperlipoproteinemic patients.  (+info)

Acute effects of intravenous infusion of ApoA1/phosphatidylcholine discs on plasma lipoproteins in humans. (8/546)

To investigate the metabolism of nascent HDLs, apoA1/phosphatidylcholine (apoA1/PC) discs were infused IV over 4 hours into 7 healthy men. Plasma total apoA1 and phospholipid (PL) concentrations increased during the infusions. The rise in plasma apoA1 was greatest in small prebeta-migrating particles not present in the infusate. Total HDL unesterified cholesterol (UC) also increased simultaneously. After stopping the infusion, the concentrations of apoA1, PL, HDL UC, and small prebeta HDLs decreased, whereas those of HDL cholesteryl ester (CE) and large alpha-migrating apoA1 containing HDLs increased. ApoB-containing lipoproteins became enriched in CEs. Addition of apoA1/PC discs to whole blood at 37 degrees C in vitro also generated small prebeta HDLs, but did not augment the transfer of UC from erythrocytes to plasma. We conclude that the disc infusions increased the intravascular production of small prebeta HDLs in vivo, and that this was associated with an increase in the efflux and esterification of UC derived from fixed tissues. The extent to which the increase in tissue cholesterol efflux was dependent on that in prebeta HDL production could not be determined. Infusion of discs also reduced the plasma apoB and apoA2 concentrations, and increased plasma triglycerides and apoC3. Thus, nascent HDL secretion may have a significant impact on prebeta HDL production, reverse cholesterol transport and lipoprotein metabolism in humans.  (+info)

Apolipoprotein C-II deficiency (APOC2) DNA Test Lab Cost INR 30000.00 best genetic offer discount price Delhi Mumbai Kolkata...  Apolipoprotein C-II deficiency (APOC2) DNA Test Lab Cost INR 30000.00 best genetic offer discount price Delhi Mumbai Kolkata...
Apolipoprotein C-II deficiency (APOC2) Test Cost INR 30000.00 Surat Pune Jaipur Lucknow Kanpur Nagpur Visakhapatnam Indore Thane Bhopal Patna Vadodara Ghaziabad Ludhiana Coimbatore Madurai Meerut Ranchi Allahabad Trivandrum Pondicherry Mysore Aligarh best offer discount price
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Abstract 19030: Apolipoprotein C-III is Significantly Reduced by Prescription Omega-3 Free Fatty Acids (Epanova) in Patients...  Abstract 19030: Apolipoprotein C-III is Significantly Reduced by Prescription Omega-3 Free Fatty Acids (Epanova) in Patients...
Background: Apolipoprotein C-III (apoC-III) inhibits lipoprotein lipase activity and hepatic uptake of triglyceride-rich lipoproteins. Elevated levels of apoC-III have been found to be an independent predictor for CHD risk and genetically reduced apoC-III is associated with protection from CHD, making apoC-III a therapeutic target. Omega-3 fatty acid formulations containing docosahexaenoic acid (DHA) have been shown to increase LDL-C in patients with severe hypertriglyceridemia (HTG). Clinical data suggest that eicosapentaenoic acid (EPA) alone, which lowers triglycerides to a similar extent as EPA + DHA, does not raise LDL-C, but also fails to lower apoC-III. Materials: The EVOLVE trial evaluated 2, 3, and 4 g/d of a novel omega-3 free-fatty acid (FFA) formulation containing both EPA + DHA compared with 4 g/d of olive oil. In 399 patients with severe HTG we evaluated the effects on plasma apoC-III levels and the correlations between change in apoC-III and change in plasma lipids (TG, LDL-C) ...
http://circ.ahajournals.org/content/126/Suppl_21/A19030
Natural Human Apolipoprotein CI (ab77901) | Abcam  Natural Human Apolipoprotein CI (ab77901) | Abcam
Buy our Natural Human Apolipoprotein CI. Ab77901 is a full length protein produced in Nativesyntheticaly and has been validated in SDS-PAGE. Abcam provides…
http://www.abcam.com/natural-human-apolipoprotein-ci-ab77901.html
S09] Rabbit Anti-Human Apolipoprotein CI Antiserum - AcademyBiomed  S09] Rabbit Anti-Human Apolipoprotein CI Antiserum - AcademyBiomed
Host Species: Rabbit Antigen: Human Apolipoprotein CI Specificity Specifically binds to human apo CI. Dilution for immunoblot and ELISA range: 1,000 to 80,000. Use: The antibody can be used for detection of apo CI in plasma and lipoproteins, immunoassays, immunoblots, enzyme conjugation, or biotinylation. Storage: -20°
https://www.academybiomed.com/products/s09-rabbit-anti-human-apolipoprotein-ci-antiserum
Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the...  Association of plasma apolipoprotein CIII, high sensitivity C-reactive protein and tumor necrosis factor-α contributes to the...
Apolipoprotein CIII (apoCIII) is an independent risk for coronary heart disease (CHD). In this study, we investigated the associations among plasma apoCIII, hs-CRP and TNF-α levels and their roles in the clinical features of CHD in the Li and Han ethnic groups in China. A cohort of 474 participants was recruited (238 atherosclerotic patients and 236 healthy controls) from the Li and Han ethnic groups. Blood samples were obtained to evaluate apoCIII, TNF-α, hs-CRP and lipid profiles. Chi-squared, t-tests, and Kruskal-Wallis or Wilcoxon-Mann-Whitney tests, Pearson or Spearman correlation tests and multiple unconditional logistic regression were employed to analyze lipid profiles and variations in plasma apoCIII, TNF-α, hs-CRP in subgroups of CHD and their contributions to CHD using SPSS version 20.0 software. Compared to healthy participants, unfavorable lipid profiles were identified in CHD patients with enhanced systolic pressure, diastolic pressure, fasting blood sugar (FBS), TG, TC, LDL-C, apoB, Lp
https://lipidworld.biomedcentral.com/articles/10.1186/s12944-018-0830-5
Sialidase Activity Acting on Apolipoprotein CIII 1 and 2 in Human Leukocytes and Platelets | Clinical Science | Portland Press  Sialidase Activity Acting on Apolipoprotein CIII 1 and 2 in Human Leukocytes and Platelets | Clinical Science | Portland Press
C H Bolton, A P Corfield, L G Downs; Sialidase Activity Acting on Apolipoprotein CIII 1 and 2 in Human Leukocytes and Platelets. Clin Sci (Lond) 1 January 1984; 67 (s9): 15P. doi: https://doi.org/10.1042/cs067015P. Download citation file:. ...
https://portlandpress.com/clinsci/article-abstract/67/s9/15P/104767/Sialidase-Activity-Acting-on-Apolipoprotein-CIII-1?redirectedFrom=fulltext
Apolipoprotein CIII overexpression exacerbates die... - BV FAPESP  Apolipoprotein CIII overexpression exacerbates die... - BV FAPESP
RAPOSO, HELENA F.... Apolipoprotein CIII overexpression exacerbates diet-induced obesity due to adipose tissue higher exogenous lipid uptake and retention and lower lipolysis rates. NUTRITION & METABOLISM 12 n. p. DEC 23 2015. Journal article.
https://bv.fapesp.br/en/publicacao/114524/apolipoprotein-ciii-overexpression-exacerbates-diet-induced/
Plus it  Plus it
We provide new information on the dose-ranging effect of rosuvastatin, a potent HMG-CoA (or 3-hydroxy-3-methyl-glutaryl-CoA) reductase inhibitor, on VLDL apoC-III metabolism in subjects with the metabolic syndrome. We demonstrated that rosuvastatin dose-dependently decreased VLDL apoC-III concentrations by increasing the FCR and decreasing the PR of VLDL apoC-III. These results add further to our work on the dose-dependent effect of rosuvastatin on apoB-containing lipoproteins and HDL particle kinetics in the same subjects (13,14).. Hypertriglyceridemia in insulin-resistant states, including the metabolic syndrome, results from overproduction and reduced catabolism of TRL and their remnants. These kinetic aberrations may be related to altered VLDL apoC-III metabolism. Previous studies demonstrated that overproduction of VLDL apoC-III explained the higher VLDL apoC-III concentration in these subjects (17). The increased VLDL apoC-III concentration and production rate were associated with elevated ...
http://care.diabetesjournals.org/content/31/8/1656
Distribution of apolipoprotein C-II mRNA and protein in | Open-i  Distribution of apolipoprotein C-II mRNA and protein in | Open-i
Distribution of apolipoprotein C-II mRNA and protein in the perinatal mouse lung. Mouse tissue sections are from saccular stage (A, B, H, GD 19.5; C, G, PN 0; I
https://openi.nlm.nih.gov/detailedresult.php?img=PMC2991289_1471-213X-10-111-5&req=4
Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III - UCL Discovery  Lipid-interacting properties of the N-terminal domain of human apolipoprotein C-III - UCL Discovery
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
http://discovery.ucl.ac.uk/77054/
Apolipoprotein E and apolipoprotein CI are involved in cognitive impairment progression in Chinese late-onset Alzheimers...  Apolipoprotein E and apolipoprotein CI are involved in cognitive impairment progression in Chinese late-onset Alzheimer's...
According to a recent study reported in the Neural Regeneration Research, APOE ε4 plays an important role in augmenting cognitive decline, and APOC1 H2 may act synergistically with APOE ε4 in increasing the risk of cognitive decline in Chinese patients with late-onset Alzheimers disease.
https://www.eurekalert.org/pub_releases/2014-09/nrr-aaa090414.php
VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in...  VLDL and apolipoprotein CIII induce ER stress and inflammation and attenuate insulin signalling via Toll-like receptor 2 in...
C2C12 myotubes exposed to VLDL showed increased levels of ER stress and inflammatory markers whereas peroxisome proliferator-activated receptor γ co-activator 1α (PGC-1α) and AMP-activated protein kinase (AMPK) levels were reduced and the insulin signalling pathway was attenuated. The effects of VLDL were also observed in isolated skeletal muscle incubated with VLDL. The changes caused by VLDL were dependent on extracellular signal-regulated kinase (ERK) 1/2 since they were prevented by the ERK1/2 inhibitor U0126 or by knockdown of this kinase by siRNA transfection. ApoCIII mimicked the effects of VLDL and its effects were also blocked by ERK1/2 inhibition, suggesting that this apolipoprotein was responsible for the effects of VLDL. Skeletal muscle from transgenic mice overexpressing apoCIII showed increased levels of some ER stress and inflammatory markers and increased phosphorylated ERK1/2 levels, whereas PGC-1α levels were reduced, confirming apoCIII effects in vivo. Finally, incubation ...
https://link.springer.com/article/10.1007/s00125-017-4401-5
Genetic Variant in Apolipoprotein C3 Gene and Fatty Liver in Obese Children - No Study Results Posted - ClinicalTrials.gov  Genetic Variant in Apolipoprotein C3 Gene and Fatty Liver in Obese Children - No Study Results Posted - ClinicalTrials.gov
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
https://clinicaltrials.gov/ct2/show/results/NCT01682655
A structural model for apolipoprotein C-II amyloid fibrils : experimental characterization and molecular dynamics simulations ...  A structural model for apolipoprotein C-II amyloid fibrils : experimental characterization and molecular dynamics simulations ...
The self-assembly of specific proteins to form insoluble amyloid fibrils is a characteristic feature of a number of age-related and debilitating diseases. Lipid-free human apolipoprotein C-II (apoC-II) forms characteristic amyloid fibrils and is one of several apolipoproteins that accumulate in amyloid deposits located within atherosclerotic plaques. X-ray diffraction analysis of aligned apoC-II fibrils indicated a simple cross-beta-structure composed of two parallel beta-sheets. Examination of apoC-II fibrils using transmission electron microscopy, scanning transmission electron microscopy, and atomic force microscopy indicated that the fibrils are flat ribbons composed of one apoC-II molecule per 4.7-A rise of the cross-beta-structure. Cross-linking results using single-cysteine substitution mutants are consistent with a parallel in-register structural model for apoC-II fibrils. Fluorescence resonance energy transfer analysis of apoC-II fibrils labeled with specific fluorophores provided ...
https://edoc.unibas.ch/21186/
The circularization of amyloid fibrils formed by apolipoprotein C-II. - Semantic Scholar  The circularization of amyloid fibrils formed by apolipoprotein C-II. - Semantic Scholar
Amyloid fibrils have historically been characterized by diagnostic dye-binding assays, their fibrillar morphology, and a cross-beta x-ray diffraction pattern. Whereas the latter demonstrates that amyloid fibrils have a common beta-sheet core structure, they display a substantial degree of morphological variation. One striking example is the remarkable ability of human apolipoprotein C-II amyloid fibrils to circularize and form closed rings. Here we explore in detail the structure of apoC-II amyloid fibrils using electron microscopy, atomic force microscopy, and x-ray diffraction studies. Our results suggest a model for apoC-II fibrils as ribbons approximately 2.1-nm thick and 13-nm wide with a helical repeat distance of 53 nm +/- 12 nm. We propose that the ribbons are highly flexible with a persistence length of 36 nm. We use these observed biophysical properties to model the apoC-II amyloid fibrils either as wormlike chains or using a random-walk approach, and confirm that the probability of ring
https://www.semanticscholar.org/paper/The-circularization-of-amyloid-fibrils-formed-by-a-Hatters-MacRaild/46f282cb627acdd83087a34adf42cd5ca7aa4638
Native Human Apolipoprotein C-I Protein | Cell Sciences  Native Human Apolipoprotein C-I Protein | Cell Sciences
Prices are in US dollars.. These products are for laboratory research purposes only, not for any human or animal diagnostic or therapeutic use.. All site content © 2017 Cell Sciences, Inc.. ...
http://www.cellsciences.com/native-human-apolipoprotein-c-i-protein
Effect of Synthetic Truncated Apolipoprotein C-I Peptide on Plasma Lipoprotein Cholesterol in Nonhuman Primates  Effect of Synthetic Truncated Apolipoprotein C-I Peptide on Plasma Lipoprotein Cholesterol in Nonhuman Primates
BioMed Research International is a peer-reviewed, Open Access journal that publishes original research articles, review articles, and clinical studies covering a wide range of subjects in life sciences and medicine. The journal is divided into 55 subject areas.
https://www.hindawi.com/journals/bmri/2004/795181/abs/
HIE Multimedia - Apolipoprotein CII  HIE Multimedia - Apolipoprotein CII
Cholesterol and triglyceride test - Animation Maybe youve been eating fast food more often than you should, or youre not getting your recommended two-and-a-half hours of exercise each week. Or, it could be that you smoke, or your blood pressure is too high. Well, for whatever reason, you may be concerned about your risk of getting heart disease. Well, a few tests can help you learn that risk, so you can start making healthy lifestyle changes to reduce it. A coronary risk profile is a group of blood tests that measure your cholesterol and triglyceride levels. Why is it important to know these levels? Because if you have too much of these substances in your blood from eating foods like burgers and French fries, they can clog your arteries. Eventually your arteries can become so clogged that youll have a heart attack or stroke. Men should have their cholesterol tested by the time theyre 35. Women should have it checked by age 45. If you have a condition like diabetes, heart disease, stroke, or ...
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Apolipoproteins - LabCE.com, Laboratory Continuing Education  Apolipoproteins - LabCE.com, Laboratory Continuing Education
Apolipoproteins have multiple roles. One role is to increase the overall solubility of the lipid particle, helping it to dissolve in the aqueous environment of the blood (apolipoproteins are amphipathic, or detergent-like proteins). Apolipoproteins can also function as enzyme co-factors (receptor ligands), facilitating the transfer of their lipid cargo to specific cells. Thus, the apoliproteins are the "smart" or working-end of the lipoprotein particle. The apolipoproteins dictate where the particles will dock and where they can bind, and in so doing the apolipoproteins regulate lipid metabolism in the body. So although the particles are composed of phospholipids and have lipid cargo, the few proteins on their surface are what give them their collective name of lipoproteins ...
https://www.labce.com/spg659280_apolipoproteins.aspx
Purification of biologically active apolipoproteins by chromatofocussing<...  Purification of biologically active apolipoproteins by chromatofocussing<...
TY - JOUR. T1 - Purification of biologically active apolipoproteins by chromatofocussing. AU - McLeod, Roger. AU - Lacko, Andras G.. AU - Pritchard, P. Haydn. AU - Frohlich, Jiri. PY - 1986/1/1. Y1 - 1986/1/1. N2 - Chromatofocussing has been used to isolate homogeneous apolipoproteins (apo) from human very-low-density lipoproteins and high-density lipoproteins with protein recovery of 70%. The inclusion of sulfhydryl-reducing agent (dithiothreitol) was required during solubilization of the lipoproteins (following delipidation) to achieve reproducible elution profiles. Removal of polyvalent buffers from apoproteins was rapidly accomplished on small columns of hydroxylapatite. The biological activity of purified apo AI and apo CII was confirmed by assessment of their ability to activate lecithin:cholesterol acyltransferase or lipoprotein lipase, respectively. Functional properties of isolated apo E were assessed by in vitro interaction with the low-density lipoprotein receptor expressed by ...
https://experts.unthsc.edu/en/publications/purification-of-biologically-active-apolipoproteins-by-chromatofo
Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases | Protocol  Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases | Protocol
Recent development in gene targeting tools makes production of knockout (KO) rabbits possible. In the present work, we generated five...
https://www.jove.com/video/50957/production-apolipoprotein-c-iii-knockout-rabbits-using-zinc-finger
Absolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction | SpringerLink  Absolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction | SpringerLink
Apolipoproteins have important structural and functional roles in several lipoprotein particles. Apolipoproteins regulate lipid metabolism, adipose tissue, and energy production and serve major...
https://link.springer.com/protocol/10.1007%2F978-1-0716-0471-7_27
Product Overview anti-Apolipoprotein C-II Antibodies  Product Overview anti-Apolipoprotein C-II Antibodies
Order monoclonal and polyclonal Apolipoprotein C-II antibodies for many applications. Selected quality suppliers for anti-Apolipoprotein C-II antibodies.
http://www.antibodies-online.com/abstract/Apolipoprotein+C-II+
Anti-Apolipoprotein CIII antibody (ab21032) | Abcam  Anti-Apolipoprotein CIII antibody (ab21032) | Abcam
Rabbit polyclonal Apolipoprotein CIII antibody validated for WB, ELISA, ICC/IF, sELISA and tested in Human. Referenced in 3 publications. Immunogen…
http://www.abcam.com/apolipoprotein-ciii-antibody-ab21032.html
GENETIC-VARIATION AT THE APOLIPOPROTEIN GENE LOCI CONTRIBUTE TO RESPONSE OF PLASMA-LIPIDS TO DIETARY CHANGE - UCL Discovery  GENETIC-VARIATION AT THE APOLIPOPROTEIN GENE LOCI CONTRIBUTE TO RESPONSE OF PLASMA-LIPIDS TO DIETARY CHANGE - UCL Discovery
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
http://discovery.ucl.ac.uk/1300903/
quick facts about schedule IV drugs and C-IV drugs  quick facts about schedule IV drugs and C-IV drugs
partial refills of Schedule IV controlled substance prescriptions are permissible under federal regulations provided that each partial filling is dispensed and recorded in the same manner as a refilling (i.e., date refilled, amount dispensed, initials of dispensing pharmacist, etc.), the total quantity dispensed in all partial fillings does not exceed the total quantity prescribed and no dispensing occurs after six months past the date of issue ...
http://takerx.com/scheduIV.html
2C-I(sales5@kaseeypharm.com)  2C-I([email protected])
... from Kaseey Industry co.,ltd on Manufacturer.com. This supplier is located in Shijiazhuang, China in the province of Hebei.
http://www.manufacturer.com/2c-isales5kaseeypharmcom-products-p7043313
ApoC-II | definition of ApoC-II by Medical dictionary  ApoC-II | definition of ApoC-II by Medical dictionary
Looking for online definition of ApoC-II in the Medical Dictionary? ApoC-II explanation free. What is ApoC-II? Meaning of ApoC-II medical term. What does ApoC-II mean?
http://medical-dictionary.thefreedictionary.com/ApoC-II
Protocols and Video Articles Authored by Jianglin Fan  Protocols and Video Articles Authored by Jianglin Fan
Jianglin Fan is the author of this article in the Journal of Visualized Experiments: Production of Apolipoprotein C-III Knockout Rabbits using Zinc Finger Nucleases
https://www.jove.com/author/Jianglin_Fan
APOC3 rabbit monoclonal antibody - (H00000345-K) - Products - Abnova  APOC3 rabbit monoclonal antibody - (H00000345-K) - Products - Abnova
Rabbit monoclonal antibody raised against a human APOC3 peptide using ARM Technology. A synthetic peptide of human APOC3 is used for rabbit immunization.Customer or Abnova will decide on the preferred peptide sequence. (H00000345-K) - Products - Abnova
http://www.abnova.com/products/products_detail.asp?catalog_id=H00000345-K
Explore N-(2C-I) fentanyl | TiHKAL · info  Explore N-(2C-I) fentanyl | TiHKAL · info
Explore the structures and analogues of N-{1-[2-(4-Iodo-2,5-dimethoxyphenyl)ethyl]piperidin-4-yl}-N-phenylpropanamide, N-(2C-I) fentanyl in book II of TiHKAL: The Continuation. Alexander & Ann Shulgin
https://isomerdesign.com/PiHKAL/explore.php?domain=tk&id=14009
EXPOSE yourself - CIII - Page 32  EXPOSE yourself - CIII - Page 32
WELCOME to the 103rd Season of the TOK-cok, SING-song, FOOD-Loving, BBB-spreading & Cat-Loving thread! Earlier threads - EXPOSE yourself - I EXPOSE yourself - II EXPOSE yourself - III EXPOSE yourself - IV EXPOSE yourself - V EXPOSE yourself - VI
http://www.clubsnap.com/forums/showthread.php?t=829330&page=32
EXPOSE yourself - CIII - Page 4  EXPOSE yourself - CIII - Page 4
WELCOME to the 103rd Season of the TOK-cok, SING-song, FOOD-Loving, BBB-spreading & Cat-Loving thread! Earlier threads - EXPOSE yourself - I EXPOSE yourself - II EXPOSE yourself - III EXPOSE yourself - IV EXPOSE yourself - V EXPOSE yourself - VI
http://www.clubsnap.com/forums/showthread.php?t=829330&page=4
Inhibition of lipoprotein lipase activity by high density lipoprotein & apolipoproteins C, E & A in rhesus monkeys. - Semantic...  Inhibition of lipoprotein lipase activity by high density lipoprotein & apolipoproteins C, E & A in rhesus monkeys. - Semantic...
Experiments were conducted to study the effects of high density lipoprotein (HDL) and apolipoproteins C, E, and A on lipoprotein lipase activity in rhesus monkeys. The lipoprotein lipase activity was inhibited up to 32 +/- 6 per cent by monkey HDL. This inhibition was considerably decreased (2 +/- 0.02%) by using apolipoprotein-poor HDL. Apolipoproteins C and E inhibited the hydrolysis of activated intralipid by monkey lipoprotein lipase to a maximum of 83 +/- 7 and 57 +/- 5 per cent respectively. Apolipoprotein A produced little inhibition of lipoprotein lipase activity. The results of these studies demonstrate that HDL and apolipoproteins compete with the substrate for the binding to lipoprotein lipase in rhesus monkeys.
https://www.semanticscholar.org/paper/Inhibition-of-lipoprotein-lipase-activity-by-high-Dahiya-Sharma/97deade5afd1ff12a18a1032d18bfc7297e4c354
Further Observations on the Activation and Inhibition of Lipoprotein Lipase by Apolipoproteins | Circulation Research  Further Observations on the Activation and Inhibition of Lipoprotein Lipase by Apolipoproteins | Circulation Research
ApoC-II was the only apolipoprotein from human very low density lipoprotein that activated rat adipose tissue lipoprotein lipase. Activation was blocked by antiserum against apoC-II. Addition of increasing amounts of activator did not alter the apparent Km of lipoprotein lipase (0.32 mM triolein), but it did produce a progressive increase in the apparent Vmax from 0.8 to 2.2 µmoles free fatty acid/mg hour-1. Substrate concentrations above 1.27 mM triolein diminished activation by 0.25-5.0 µg/ml of apoC-II as much as 20%. Reversal of this apparent substrate inhibition was achieved by increasing the activator concentration to 50.0 µg/ml. Each of five nonactivating apolipoproteins-apoC-I, C-III-1, C-III-2, A-I, and A-II-inhibited lipoprotein lipase up to 85-100%. ApoC-II also produced less inhibition under appropriate conditions. Inhibition was dependent on apoprotein concentration, inversely related to substrate triglyceride concentration, and unobserved with nonlipoprotein proteins. The ...
http://circres.ahajournals.org/content/33/4/403
The amphipathic helix in the exchangeable apolipoproteins : a review of secondary structure and function - Institutional...  The amphipathic helix in the exchangeable apolipoproteins : a review of secondary structure and function - Institutional...
Site-directed mutagenesis and other molecular biology-based techniques are now available for probing the amphipathic alpha-helix structural motif in the exchangeable apolipoproteins. Here we survey the published literature on lipid-binding and functional domains in apolipoproteins A-I, A-II, A-IV, C-I, C-II, C-III, and E and compare these results with recently developed computer methods for analysis of the location and properties of amphipathic helixes. This comparison suggests that there are at least three distinct classes of amphipathic helixes (classes A, Y, and G*) in the exchangeable apolipoproteins whose distribution varies within and between the seven apolipoproteins. This comparison further suggests that lipid affinity resides largely in class A amphipathic helixes (Segrest, J. P., et al. 1990. Proteins. 8: 103) and that variations in structure and/or numbers of class A domains in individual apolipoproteins allow a range of lipid affinities from high to low. The positions of the four a ...
https://repository.uantwerpen.be/link/irua/106347
LongevityMap variant  LongevityMap variant
This gene encodes a member of the apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016 ...
http://genomics.senescence.info/longevity/entry.php?id=279
Hnf4a - Hepatocyte nuclear factor 4-alpha - Rattus norvegicus (Rat) - Hnf4a gene & protein  Hnf4a - Hepatocyte nuclear factor 4-alpha - Rattus norvegicus (Rat) - Hnf4a gene & protein
Transcriptionally controlled transcription factor. Binds to DNA sites required for the transcription of alpha 1-antitrypsin, apolipoprotein CIII, transthyretin genes and HNF1-alpha. May be essential for development of the liver, kidney and intestine.
http://www.uniprot.org/uniprot/P22449
Non-Mammalian Host Systems for the Expression of Mammalian Apolipoproteins | Springer for Research & Development  Non-Mammalian Host Systems for the Expression of Mammalian Apolipoproteins | Springer for Research & Development
Recombinant mammalian apolipoproteins have been expressed in a variety of cultured mammalian cell lines (Reardon et al. 1986; Mallory et al. 1987; Blackhart et al. 1990; Yao et al. 1991), transgenic...
https://rd.springer.com/chapter/10.1007/978-3-642-84634-2_13
Apolipoproteins | ProSpec  Apolipoproteins | ProSpec
ProSpecs Apolipoproteins include: Clusterin Human Recombinant, Clusterin Rat Recombinant, Apolipoprotein-D Human Recombinant, Human Apolipoprotein-J, Apolipoprotein-J Canine Recombinant
https://www.prospecbio.com/apoliproteins/
IONIS APOCIII LRx - AdisInsight  IONIS APOCIII LRx - AdisInsight
Ionis Pharmaceuticals, through its wholly owned subsidiary Akcea Therapeutics, is developing IONIS APOCIII LRx, a GalNAc3 conjugated antisense oligonucleotide
http://adisinsight.springer.com/drugs/800048476?error=cookies_not_supported&code=933f003e-53ed-44b7-897f-4a450ca771ff
APOC1 ELISA Kits from Biorbyt | Biocompare.com  APOC1 ELISA Kits from Biorbyt | Biocompare.com
Compare APOC1 ELISA Kits from Biorbyt from leading suppliers on Biocompare. View specifications, prices, citations, reviews, and more.
https://www.biocompare.com/pfu/110627/soids/2-320235/ELISA_Kit/ELISA_APOC1?vids=104369
apoc2-mutant zebrafish to study hypertriglyceridemia | Disease Models & Mechanisms  apoc2-mutant zebrafish to study hypertriglyceridemia | Disease Models & Mechanisms
Hypertriglyceridemia is characterised by high levels of triglycerides in the blood and is associated with several metabolic disorders and with an increased risk of cardiovascular disease. It can be caused by several factors, including obesity, excessive alcohol consumption and an unhealthy diet. In addition, individuals with genetic defects in apolipoprotein-CII (APOC2; an activator of lipoprotein lipase, which hydrolyses triglycerides to deliver fatty acids to body tissues) display hypertriglyceridemia even on a normal diet. Here, Yury Miller and colleagues generated mutant zebrafish bearing apoc2 loss-of-function mutations. These animals, fed a normal diet, exhibit severe hypertriglyceridemia and accumulate lipid and lipid-laden macrophages in the vasculature, which constitute early events in the development of human atherosclerotic lesions. Notably, injection of wild-type zebrafish plasma with functional Apoc2 or a human APOC2-mimetic peptide can rescue hypertriglyceridemia in the mutants. ...
https://dmm.biologists.org/content/8/8/e0801
Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease. |...  Effects of polymorphisms in apolipoproteins E, A-IV, and H on quantitative traits related to risk for cardiovascular disease. |...
The impact of the common alleles at structural loci coding for apolipoprotein (apos) A-IV, E, and H on 12 quantitative risk factors for cardiovascular disease (apos A-I, A-II, B, C-II, C-III, and E; total cholesterol; triglycerides; high density lipoprotein cholesterol; systolic blood pressure; diastolic blood pressure; and red blood cell sodium-lithium countertransport) was estimated in 453 unrelated individuals (227 men and 226 women) aged 26-63 years from the Rochester Family Heart Study, who were not using medications affecting lipid levels or blood pressure. Each risk factor was adjusted for concomitants (assay date, age, age, squared, height, weight and smoking status) before the genotypic effects on mean levels and variances were estimated. Allele frequencies were the same in men and women and were similar to those observed in other studies of US Caucasians. There were very different gender-specific estimates of the relative contribution of concomitants, measured genetic effects, and ...
http://atvb.ahajournals.org/content/11/5/1330
Summary: Monoklonale Antik rper und Antisense-Oligonukleotide Biologika als Zukunft in der Kardiologie? // Monoclonal...  Summary: Monoklonale Antik rper und Antisense-Oligonukleotide Biologika als Zukunft in der Kardiologie? // Monoclonal...
Another substance class on the rise in cardiovascular medicine are so-called anti-sense oligonucleotides, single strands of DNA or RNA binding complementary to a chosen mRNA sequence, thereby preventing protein translation. Besides a fascinating novel anti-coagulatory approach by inhibiting coagulation factor XI production, the biggest focus of this novel therapeutic approach lies on lipidology. Within this review we will highlight the current evidence on antisense therapy against apolipoprotein B, apolipoprotein A as well as apolipoprotein CIII, that are in very different stages of development, however, with some exciting early data.. Kurzfassung: Biologika begr nden eine neue Medikamentenklasse, werden biotechnologisch hergestellt und greifen gezielt in molekularbiologische Mechanismen ein. Lange Zeit eine Dom ne der H matologie, Onkologie sowie der Rheumatologie, treten monoklonale Antik rper als Therapeutika nun auch langsam in der Kardiologie ihren Siegeszug an. Neben dem schon seit mehr ...
http://h1707126.stratoserver.net/journals/summary/13814.html
Vacuolar H+-ATPase meets glycosylation in patients with cutis laxa :: MPG.PuRe  Vacuolar H+-ATPase meets glycosylation in patients with cutis laxa :: MPG.PuRe
Autor: Guillard, Mailys et al.; Genre: Zeitschriftenartikel; Im Druck veröffentlicht: 2009-09; Keywords: Glycosylation; Cutis laxa; V-ATPase; Congenital disorders of glycosylation; OMIM 219200; Apolipoprotein C III; Titel: Vacuolar H+-ATPase meets glycosylation in patients with cutis laxa
http://pubman.mpdl.mpg.de/pubman/faces/viewItemOverviewPage.jsp?itemId=escidoc:1584090
Apolipoprotein A-IV/ApoA4 Antibody Pair (H00000337-AP21): Novus Biologicals  Apolipoprotein A-IV/ApoA4 Antibody Pair (H00000337-AP21): Novus Biologicals
Apolipoprotein A-IV/ApoA4 Antibody Pair. Matched antibody pairs validated for ELISA or IP-Western Blot. Backed by our 100% Guarantee.
https://www.novusbio.com/products/apolipoprotein-a-iv-apoa4-antibody-pair_h00000337-ap21
Human Apolipoprotein A-IV Reduces Secretion of Proinflammatory Cytokines and Atherosclerotic Effects of a Chronic Infection...  Human Apolipoprotein A-IV Reduces Secretion of Proinflammatory Cytokines and Atherosclerotic Effects of a Chronic Infection...
Thank you for your interest in spreading the word on Arteriosclerosis, Thrombosis, and Vascular Biology.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
http://atvb.ahajournals.org/content/early/2004/01/29/01.ATV.0000119353.03690.22
100mg of 2c-i on the way...tips? - Trip Reports - Shroomery Message Board  100mg of 2c-i on the way...tips? - Trip Reports - Shroomery Message Board
no scale, but i want to dose between 20-25mg. i used to eyeball 2c-t-7 doses by dividing the 100mg of powder into ~equal piles...suggestions? (feel free to suggest anything regarding 2c-i...doesnt
https://www.shroomery.org/forums/showflat.php/Number/2166301
Phenotypes for Ldlr Tg(APOC3)3707Bres MGI:4367083 MGI Mouse  Phenotypes for Ldlr Tg(APOC3)3707Bres MGI:4367083 MGI Mouse
View Ldlr/Ldlr Tg(APOC3)3707Bres/? involves: 129S7/SvEvBrd * C57BL/6J * CBA/J: phenotypes, images, diseases, and references.
http://www.informatics.jax.org/allele/genoview/MGI:4367083
Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population | Lipids...  Apolipoprotein C3 genetic polymorphisms are associated with lipids and coronary artery disease in a Chinese population | Lipids...
A lot of studies have been conducted to examine the association of genetic polymorphism and risk of CAD. A meta-analysis of 9 studies that included 1,700 CAD patients and 4,081 healthy controls suggested that ALDH2 Glu504Lys polymorphism may be associated with increased risk of CAD and myocardial infarction in East Asians, especially among Chinese and Korean populations [22]. A meta-analyses of 26 studies that included 12,776 cases and 6,371 controls found that -1562C,T polymorphism in the promoter region of matrix metalloproteinase-9 may have association with CAD risk in Asian populations [23]. A meta-analyses of 22 studies including 3,502 CAD patients and 3,071 controls suggested that the angiotensin II receptor, type 1 gene A1166C polymorphism might be a genetic marker for the development of CAD in Chinese populations, especially in the context of studies with northern and older subjects [24, 25]. A meta-analyses of 11 studies involving 22,584 subjects showed that PTGS2 -765G/C was associated ...
https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-13-170
Activation of peroxisome proliferator activated receptor-gamma results in an atheroprotective apolipoprotein profile in HepG2...  Activation of peroxisome proliferator activated receptor-gamma results in an atheroprotective apolipoprotein profile in HepG2...
Background: Insulin resistance is linked to dyslipidemia, characterized by a decrease in high density lipo-proteins and an increase in low density lipoproteins. Thiazolidinediones (TZDs) are insulin-sensitizing agents used to improve glycemic control in patients with type 2 diabetes. Recently, the safety of certain TZD regimens has been questioned because of associated adverse effects on the plasma lipid profile. We examined the effect of a TZD, Ciglitazone, on apolipoprotein synthesis and secretion in human liver HepG2 cells. Methods and Results: The effect of Ciglitazone treatment on apolipoprotein synthesis was addressed at the level of transcription, translation and secretion. RT-PCR showed that Ciglitazone increased the transcription of apoE and apoAI but reduced the levels of apoCI and apoB mRNA. Western blot analysis showed an increase in apoAI and apoE secreted in the cell culture media, whereas the amounts of apoB100 and apoCI were reduced. To confirm that Ciglitazone regulates apolipoprotein
https://m.scirp.org/papers/21799
Research - research*eu - Topics - Environment - Special GEO - The inner core - remnant of a planets birth  Research - research*eu - Topics - Environment - Special GEO - The inner core - remnant of a planet's birth
Holding the secrets of our planets formation, the Earths core is something of a holy grail for the geosciences. The exact composition of its liquid and solid components remains a mystery, as do the complex phenomena that occur there. Located at a depth of over 3 000 km, its inaccessibility obliges researchers to be inventive. Only one thing is certain: the inner core that constitutes its heart is crystallising, thereby heralding - albeit in the very long term - the likely disappearance of our protective magnetic field.
http://ec.europa.eu/research/research-eu/earth/article_earth10_en.html
Upsher-Smith Receives Tentative NDA Approval for Vogelxo™ (testosterone) Gel CIII  Upsher-Smith Receives Tentative NDA Approval for Vogelxo™ (testosterone) Gel CIII
MAPLE GROVE, Minn., Aug. 16, 2013 /PRNewswire/ -- Upsher-Smith Receives Tentative NDA Approval for Vogelxo™ (testosterone) Gel CIII.
https://www.prnewswire.com/news-releases/upsher-smith-receives-tentative-nda-approval-for-vogelxo-testosterone-gel-ciii-219965231.html
Leica 마크로줌 & 디지털 현미경 | (주)와이에스피  Leica 마크로줌 & 디지털 현미경 | (주)와이에스피
Leica의 매크로현미경(Macroscope)는 시판되는 제품 중 최고 수준의 정밀도를 가지며 산업, 의학, 연구 분야에서 다채로운 목적으로 사용됩니다. 편리한 매크로스코프 Leica Macroscope는 APO 16:1 줌이 주는 탁월한 광학 특성과 함께 작업 편리성에 있어 최고의
http://ysp.kr/?page_id=623
Targeting residual cardiovascular risk: lipids and beyond…  Targeting residual cardiovascular risk: lipids and beyond…
Added to this, both observational and genetic studies have been concordant in showing that remnant cholesterol (which includes intermediate-density lipoproteins, very-low-density lipoproteins, and chylomicron remnants, the products of the lipolytic degradation of triglyceride-rich lipoproteins produced by the liver and intestine) is causal for ischaemic heart disease 8. Genetic studies have also shown associations between different players in triglyceride metabolism, apolipoprotein CIII and the angiopoietins-like 3 and 4 (ANGPTL3, ANGPTL4) and coronary artery disease (9-11); the latest Focus report discusses recent data for ANGPTL3 inhibition. Moreover, given the pivotal role of peroxisome proliferator-activated receptor ? (PPAR?) in controlling the expression of a number of key genes in triglyceride and HDL metabolism, efforts have been directed to modulating the unique receptor-cofactor binding profile to improve the potency and selectivity of PPAR? ligands (the SPPARM? concept). The ...
http://www.r3i.org/editorial-88
Apolipoprotein AV: Low concentration, high impact :: TNO Repository  Apolipoprotein AV: Low concentration, high impact :: TNO Repository
Chemicals / CAS: lipoprotein lipase, 83137-80-8, 9004-02-8; APOA5 protein, human; Apolipoproteins A; Apolipoproteins; Triglycerides ...
https://repository.tudelft.nl/view/tno/uuid%3A42f46f9a-886b-4b65-a26a-349dd9ac9b40
Mylan Pharmaceuticals Initiates Voluntary Nationwide Recall of One Lot of Alprazolam Tablets, ...  Mylan Pharmaceuticals Initiates Voluntary Nationwide Recall of One Lot of Alprazolam Tablets, ...
MORGANTOWN, W.Va., Oct. 25, 2019 /PRNewswire/ -- Mylan Pharmaceuticals Inc. is conducting a voluntary nationwide recall of one lot (see table below) of Alprazolam Tablets, USP C-IV 0.5 mg, to the consumer/user level. This lot is being recalled due to the potential presence of foreign substance. Clinical impact from the foreign material, if present, is expected to be rare, but the re...
https://medworm.com/739006556/mylan-pharmaceuticals-initiates-voluntary-nationwide-recall-of-one-lot-of-alprazolam-tablets-/
Indian Heart Journal  Indian Heart Journal
Apolipoproteins AI/B/E gene polymorphism and their plasma levels in patients with coronary artery disease in a tertiary care-center of Eastern India ...
http://indianheartjournal.com/Nov-Dec-2013/Nov-Dec-2013.html
APOC1 ELISA & Assay Kits  APOC1 ELISA & Assay Kits
66 products from 17 suppliers. Compare and order APOC1 ELISA Kits. View citations, images, detection ranges, sensitivity, prices and more. Recommended products for the most popular species. Our scientists will help you find the right ELISA kit for your needs.
https://www.antibodies-online.com/apoptosis-pathway-9/apoc1-elisa-kit-9005/
Kniphofia plant named Banana Popsicle - Terra Nova Nurseries, Inc.  Kniphofia plant named 'Banana Popsicle' - Terra Nova Nurseries, Inc.
A new and distinct |i|Kniphofia |/i|plant characterized by numerous spikes of golden yellow flowers the first year, repeat blooming from July through October in Canby, Oreg., a compact habit with mult
http://www.freepatentsonline.com/y2017/0049033.html
Apolipoproteins A Summary Report | CureHunter  Apolipoproteins A Summary Report | CureHunter
Apolipoproteins A: Structural proteins of the alpha-lipoproteins (HIGH DENSITY LIPOPROTEINS), including APOLIPOPROTEIN A-I and APOLIPOPROTEIN A-II. They can modulate the activity of LECITHIN CHOLESTEROL ACYLTRANSFERASE. These apolipoproteins are low in atherosclerotic patients. They are either absent or present in extremely low plasma concentration in TANGIER DISEASE.
http://www.curehunter.com/public/keywordSummaryD001054-Apolipoproteins-A.do
Akesis  Akesis
Fenofibrate (micronized) is a lipid regulating agent. Fenofibric acid, the active metabolite of fenofibrate, produces reductions in total-C, LDL-C, apo B, total triglycerides and VLDL in treated patients. In addition, treatment with fenofibrate results in increases in HDL-C and apoproteins apoAI and apoAII. The effects of fenofibric acid seen in clinical practice have been explained by the activation of peroxisome proliferator activated receptor (alpha) [PPAR (alpha)]. Through this mechanism, fenofibrate increases lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and reducing production of apoprotein C-III (an inhibitor of lipoprotein lipase activity). The resulting fall in triglycerides produces an alteration in the size and composition of LDL from small, dense particles (which are thought to be atherogenic due to their susceptibility to oxidation), to large buoyant particles. These larger particles have a greater affinity for cholesterol ...
http://akesissindia.com/div_pdt_read_more.php?dv_pdt_id=17
Gary L. Nelsestuen | College of Biological Sciences  Gary L. Nelsestuen | College of Biological Sciences
Yan Zhang, Alan R. Sinaiko, Gary L. Nelsestuen (2011). Glycoproteins and Glycosylation: Apolipoprotein C3 Glycoforms by top-down MALDI-TOF Mass Spectrometry" methods in Molecular Biology, in press.. D. W. Mahoney, T. M. Therneau, C. J. Heppelmann, L. Higgins, L. M. Benson, R. M. Zenka, P. Jagtap, G. L. Nelsestuen, H. R. Bergen, A. L. Oberg (2011). Relative Quantification: Characterization of bias, variability and fold changes in mass spectrometry data from iTRAQ labeled peptides. J Proteome Res. PMID: 21755926. S. K. Akkina, Y. Zhang, G. L. Nelsestuen, W. S. Oetting and H. N. Ibrahim (2009). Temporal stability of the urinary proteome after kidney transplant: more sensitive than protein composition? Journal of Proteome Research (special issue on temporal and spatial proteomics) 8, 94-103. PMID: 19012427. S. B. Harvey, Y. Zhang, J. Wilson-Grady, T. Monkkonen, G. L. Nelsestuen, R. S. Kasthuri, M. R. Verneris, T. C. Lund, E. Wesley Ely, G. R. Bernard, H. Zeisler, M. Homoncik, B. Jilma, T. Swan, and ...
https://cbs.umn.edu/contacts/gary-l-nelsestuen
Hypertriglyceridemic waist syndrome, Ask a Doctor about diagnosis, treatment and medication for Hypertriglyceridemic waist...  Hypertriglyceridemic waist syndrome, Ask a Doctor about diagnosis, treatment and medication for Hypertriglyceridemic waist...
Hypertriglyceridemic waist syndrome, Ask a Doctor about diagnosis, treatment and medication for Hypertriglyceridemic waist syndrome
https://www.healthcaremagic.com/topics/disease-and-conditions/hypertriglyceridemic-waist-syndrome/120645
Lipoproteins and Apolipoproteins Foreign Language Flashcards - Cram.com  Lipoproteins and Apolipoproteins Foreign Language Flashcards - Cram.com
Trying to learn ? We can help! Memorize these flashcards or create your own flashcards with Cram.com. Learn a new language today.
http://www.cram.com/flashcards/lipoproteins-and-apolipoproteins-357820
KAKEN - Research Projects | Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins (KAKENHI...  KAKEN - Research Projects | Physicochemical mechanism on formation and metabolism of HDL particles by apolipoproteins (KAKENHI...
Principal Investigator：Saito Hiroyuki, Project Period (FY)：2013-04-01 - 2017-03-31, Research Category：Grant-in-Aid for Scientific Research (B), Section：一般, Research Field：Physical pharmacy
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25293006/
Iorovi Medica - Laborator analize medicale :: Bucuresti, Laborator de analize, Anatomie patologica, Laborator de analize...  Iorovi Medica - Laborator analize medicale :: Bucuresti, Laborator de analize, Anatomie patologica, Laborator de analize...
Iorovi Medica Bucuresti - Laborator analize medicale - Bucuresti | , Laborator de analize, Anatomie patologica, Genetica medicala, Laborator de analize medicale complete
http://iorovimedica.ro/abonamente_medicale.php
IPI Acta Medica Indonesiana  IPI Acta Medica Indonesiana
Yunifiar M, Muhammad Qushai; Kotaki, Tomohiro; Witaningrum, Adiana Mutamsari; Khairunisa, Siti Qamariyah; Indriati, Dwi Wahyu; Meilani, Meilani; Yeheskiel, Tigor; Ueda, Shuhei; Nasronudin, Nasronudin; Kameoka, ...
http://id.portalgaruda.org/?ref=browse&mod=viewjournal&journal=10430
IPI Acta Medica Indonesiana  IPI Acta Medica Indonesiana
Yunifiar M, Muhammad Qushai; Kotaki, Tomohiro; Witaningrum, Adiana Mutamsari; Khairunisa, Siti Qamariyah; Indriati, Dwi Wahyu; Meilani, Meilani; Yeheskiel, Tigor; Ueda, Shuhei; Nasronudin, Nasronudin; Kameoka, ...
http://uad.portalgaruda.org/?ref=browse&mod=viewjournal&journal=10430
Dott. Fabrizio Camesasca - Specialista in Oftalmologia  Dott. Fabrizio Camesasca - Specialista in Oftalmologia
Fornire salute visiva, attraverso unassistenza medica e diagnostica al massimo livello, con costante attenzione allaspetto umano e alle necessità di ogni singolo Paziente.
http://camesasca.com/it/congressi
Low-resolution epitope characterisation in a family of seed apolipoproteins using polyclonal antibodies - WestminsterResearch  Low-resolution epitope characterisation in a family of seed apolipoproteins using polyclonal antibodies - WestminsterResearch
Polyclonal antibodies raised against a range of seed apolipoproteins from the family Cruciferae have been used for the first time for low resolution epitope characterisation. Antibodies were raised against the major seed apolipoproteins of Brassica napus, Sinapis alba and Raphanus sativum. In each case, the antibodies recognized, in addition to the 19-20 kDa apolipoprotein to which they were raised, similar 19-20 kDa apolipoproteins from a wide range of species in the family Cruciferae, but not in other plant families. Homologous or heterologous two-sites (sandwich) assays were performed with the format [antibody A - test apolipoprotein - antibody B - 2° antibody]. The results showed a drastically reduced antibody B binding by apolipoproteins preincubated with an antibody A. This indicated the presence of a single major epitope on many of the apolipoproteins. The antigenicity of native and denatured apolipoproteins was similar, although the antigenicity of the former was much more readily ...
http://westminsterresearch.wmin.ac.uk/4549/
Proteomes | Free Full-Text | Mass Spectrometric Studies of Apolipoprotein Proteoforms and Their Role in Lipid Metabolism and...  Proteomes | Free Full-Text | Mass Spectrometric Studies of Apolipoprotein Proteoforms and Their Role in Lipid Metabolism and...
Apolipoproteins function as structural components of lipoprotein particles, cofactors for enzymes, and ligands for cell-surface receptors. Most of the apoliporoteins exhibit proteoforms, arising from single nucleotide polymorphisms (SNPs) and post-translational modifications such as glycosylation, oxidation, and sequence truncations. Reviewed here are recent studies correlating apolipoproteins proteoforms with the specific clinical measures of lipid metabolism and cardiometabolic risk. Targeted mass spectrometric immunoassays toward apolipoproteins A-I, A-II, and C-III were applied on large cross-sectional and longitudinal clinical cohorts. Several correlations were observed, including greater apolipoprotein A-I and A-II oxidation in patients with diabetes and cardiovascular disease, and a divergent apoC-III proteoforms association with plasma triglycerides, indicating significant differences in the metabolism of the individual apoC-III proteoforms. These are the first studies of their kind, correlating
http://www.mdpi.com/2227-7382/5/4/27
Influence of PvuII (Intron 6) polymorphism of the lipoprotein lipase gene on cord plasma lipid and apolipoprotein levels in...  Influence of PvuII (Intron 6) polymorphism of the lipoprotein lipase gene on cord plasma lipid and apolipoprotein levels in...
FLow, P.-S.,Tay, J.S.H.,Arulkumaran, S.,Saha, N. (1998). Influence of PvuII (Intron 6) polymorphism of the lipoprotein lipase gene on cord plasma lipid and apolipoprotein levels in indian and chinese newborns of singapore. Pediatric Research 43 (2) : 240-244. [email protected] Repository ...
http://scholarbank.nus.edu.sg/handle/10635/37405
LongevityMap variant  LongevityMap variant
The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016 ...
http://genomics.senescence.info/longevity/entry.php?id=G225
Enzyme-linked immunosorbent assay for apolipoproteins A-I and bin urine of patients with nephrotic syndrome  Enzyme-linked immunosorbent assay for apolipoproteins A-I and bin urine of patients with nephrotic syndrome
Abstract: Enzyme-linked immunosorbent assay (ELISA) has been used formeasuring apolipoproteins A-I and B in the urine. ApoB is absentin urine of healthy subjects, and apoA-I is determined in tracequantity. In patients with chronic glomerulonephritis quantity ofapoA-I in urine was 117 times as much as in control group. ApoBis present in urine of patients in considerable quantity(1528*315 *g/l).) The ELISA method for determining apoA-I andapoB in urine makes it possible to evaluate the gravity ofpathological process in kidney ...
http://pbmc.ibmc.msk.ru/index.php/en/article/PBMC-1999-45-1-65-en
09lipRxns - II.C.i-1 Reactions of Reactions of Triglycerides Triglycerides • Hydrolysis(lipolysis triglycerides diglycerides...  09lipRxns - II.C.i-1 Reactions of Reactions of Triglycerides Triglycerides • Hydrolysis(lipolysis triglycerides diglycerides...
View Notes - 09lipRxns from FST 100A at UC Davis. II.C.i.-1 Reactions of Reactions of Triglycerides Triglycerides • Hydrolysis (lipolysis ) triglycerides diglycerides, monoglycerides, glycerol +
https://www.coursehero.com/file/6005202/09lipRxns/
Fructose Intake and Circulating Triglycerides: An Examination of the Role of APOC 3  Fructose Intake and Circulating Triglycerides: An Examination of the Role of APOC 3
Fructose consumption can lead to marked increases in plasma triglycerides in both humans and laboratory animals. We have observed that overnight access to a 16% fructose solution can promote hypertriglyceridemia in rats. Several investigators have suggested that APOC 3 may be implicated in promoting fructose-induced hypertriglyceridemia. We have examined the role of APOC 3 in liver and blood taken from rats that had been given access to a fructose solution overnight as a supplement to standard laboratory chow. Hepatic APOC3 mRNA expression from fructose alone resulted in a 14 % reduction compared to control. Interestingly, hepatic APOC3 expression was increased by about 250% in sucrose, high fructose corn syrup and glucose groups. The serum protein levels of APOC3 did not differ across groups. Contrary to our hypothesis, these results indicate that glucose containing sugars increased hepatic APOC3 mRNA expression but no sugar was capable of increasing the serum protein level.
https://www.ommegaonline.org/article-details/Fructose-Intake-and-Circulating-Triglycerides-An-Examination-of-the-Role-of-APOC-3/190
The Official AndroGel (testosterone gel) 1.62% CIII Website  The Official AndroGel (testosterone gel) 1.62% CIII Website
View the AndroGel® (testosterone gel) 1.62% CIII site, a prescription treatment for men with hypogonadism due to certain medical conditions. Learn about treatment, explore the Treatment Experience app and see support & savings. See prescribing info for benefits and risks, including BOXED WARNING on secondary exposure.
https://www.androgel.com/
APOC4 Antibody 16530-1-AP | Proteintech  APOC4 Antibody 16530-1-AP | Proteintech
APOC4 Antibody 16530-1-AP has been identified with IF, WB, ELISA. 16530-1-AP detected 17 kDa band in human plasma tissue with 1:200-1:1000 dilution...
https://www.ptglab.com/Products/APOC4-Antibody-16530-1-AP.htm
rapidmicrobiology » Lab M Showcase µPREP BPW (ISO) and Captivate O121 at Medica 2013  rapidmicrobiology » Lab M Showcase µPREP BPW (ISO) and Captivate O121 at Medica 2013
A brand new cost-effective line of bagged, sterile dehydrated culture media that is designed for fast, efficient and convenient reconstitution
http://www.rapidmicrobiology.com/news/lab-m-showcase-prep-bpw-iso-and-captivate-o121-at-medica-2013/
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
Apolipoproteins CApolipoproteinsApolipoproteins AApolipoproteins BApolipoprotein A-IApolipoprotein A-IIApolipoproteins EApolipoprotein C-IIApolipoprotein C-IIILipoproteins, HDLApolipoproteins DLipoproteinsApolipoprotein C-ICholesterolLipoproteins, VLDLTriglyceridesLipidsApolipoprotein B-100Apolipoprotein B-48Cholesterol, HDLLipoproteins, HDL3Tangier DiseasePhosphatidylcholine-Sterol O-AcyltransferaseLipoproteins, LDLNephelometry and TurbidimetryATP Binding Cassette Transporter 1Cholesterol EstersIsoelectric FocusingReceptors, LipoproteinLipid MetabolismChylomicronsCholesterol, LDLPhospholipidsUltracentrifugationHypolipoproteinemiasLipoproteins, HDL2Lipoprotein(a)LymphElectrophoresis, Polyacrylamide GelApoproteinsHyperlipidemiasLiverImmunodiffusionLipoprotein LipaseTrioleinHyperlipoproteinemia Type IVPhosphatidylcholinesKineticsATP-Binding Cassette TransportersHyperlipoproteinemiasApolipoprotein E3Chemistry, ClinicalCholesterol, VLDLHypertriglyceridemiaCholesterol Ester Transfer ProteinsLipoproteins, IDLReference ValuesScavenger Receptors, Class BFreeze DryingEthinyl EstradiolParticle SizeImmunoassaySerum Amyloid A ProteinDietary FatsMicroscopy, ElectronImmunoelectrophoresisHyperlipoproteinemia Type VAbetalipoproteinemiaDimyristoylphosphatidylcholineReceptors, ScavengerAmino Acid SequenceOleic AcidChromatography, GelMolecular WeightArteriosclerosisBiological TransportLipolysisSterol O-AcyltransferaseRats, Inbred StrainsCallitrichinaeHigh-Density Lipoproteins, Pre-betaLipaseLiposomesReceptors, LDLOleic AcidsCarrier ProteinsMolecular Sequence DataLecithin Acyltransferase DeficiencyHyperlipidemia, Familial CombinedProtein BindingAntigens, CD36ButterHyperlipoproteinemia Type IIEsterificationGlycoproteinsEmulsionsSalmonidaeBinding, Competitive
Apolipoprotein C2Apolipoprotein C2
... or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. secreted in plasma where it ... "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. Invest. ... Familial apolipoprotein CII deficiency associated with premature vascular disease". J. Clin. Invest. 80 (6): 1597-606. doi: ... "Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 84 (1): 270-3. ...
LipidLipid
In animals, when there is an oversupply of dietary carbohydrate, the excess carbohydrate is converted to triglycerides. This involves the synthesis of fatty acids from acetyl-CoA and the esterification of fatty acids in the production of triglycerides, a process called lipogenesis.[87] Fatty acids are made by fatty acid synthases that polymerize and then reduce acetyl-CoA units. The acyl chains in the fatty acids are extended by a cycle of reactions that add the acetyl group, reduce it to an alcohol, dehydrate it to an alkene group and then reduce it again to an alkane group. The enzymes of fatty acid biosynthesis are divided into two groups, in animals and fungi all these fatty acid synthase reactions are carried out by a single multifunctional protein,[88] while in plant plastids and bacteria separate enzymes perform each step in the pathway.[89][90] The fatty acids may be subsequently converted to triglycerides that are packaged in lipoproteins and secreted from the liver. The synthesis of ...
Category:Blood proteinsCategory:Blood proteins
Text is available under the Creative Commons Attribution-ShareAlike License; additional terms may apply. By using this site, you agree to the Terms of Use and Privacy Policy. Wikipedia® is a registered trademark of the Wikimedia Foundation, Inc., a non-profit organization ...
Genetic testingGenetic testing
Apolipoprotein E-associated. Elevation of both serum cholesterol and triglycerides; accelerated atherosclerosis, coronary heart ...
Familial hypercholesterolemiaFamilial hypercholesterolemia
Apolipoprotein BEdit. Apolipoprotein B, in its ApoB100 form, is the main apolipoprotein, or protein part of the lipoprotein ... Class III: LDLR does not properly bind LDL on the cell surface because of a defect in either apolipoprotein B100 (R3500Q) or in ... LDL cholesterol normally circulates in the body for 2.5 days, and subsequently the apolipoprotein B portion of LDL cholesterol ... or apolipoprotein B (ApoB), which is the part of LDL that binds with the receptor; mutations in other genes are rare.[1] People ...
Farnesoid X receptorFarnesoid X receptor
"Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression". Gastroenterology. 125 (2): 544-55. doi:10.1016/ ...
Long non-coding RNALong non-coding RNA
A recent study found that a lncRNA in the antisense direction of the Apolipoprotein A1 (APOA1) regulates the transcription of ... Halley, Paul; Kadakkuzha, Beena (2014). "Regulation of the apolipoprotein gene cluster by a long noncoding RNA". Cell Reports. ...
Choroba Alzheimera, wolna encyklopediaChoroba Alzheimera, wolna encyklopedia
Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein. „N Engl J Med". 333 (19), s. 1242-47, 11 1995. DOI ... Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial ... a b Mahley RW, Weisgraber KH, Huang Y. Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, ...
NeurodegenerationNeurodegeneration
... alpha-synuclein can also form lipoprotein nanoparticles similar to apolipoproteins. ... "Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins". The Journal of Biological ...
阿茲海默症 - 维基百科，自由的百科全阿茲海默症 - 维基百科，自由的百科全
Apolipoprotein E）會導致類澱粉蛋白質斑塊在大腦中累積[83]，因此推測Aβ是導致阿茲海默症的原因，進一步的證據則是來自於轉殖基因老鼠實驗，研究人員在實驗老鼠身上表現突變型人類APP基因，結果發現實驗老鼠的大腦會產生纖維狀的類澱粉蛋白質斑塊 ... Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein. N Engl J Med. November 1995,
LipocalinLipocalin
... apolipoprotein D; beta-lactoglobulin; complement component C8 gamma chain; crustacyanin; epididymal-retinoic acid binding ...
GPX3GPX3
2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. ...
FOXA2FOXA2
"Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 ...
Japanese AmericansJapanese Americans
Specifically too, the apolipoprotein *e4 allele is linked to Alzheimer's disease as well. Also, there is increased coronary ... research has been put on concerning apolipoprotein E genotypes; this polymorphism has three alleles (*e2, *e3, and *e4)and was ...
ApoA-1 MilanoApoA-1 Milano
Apolipoprotein A-1 Milano (also ETC-216, now MDCO-216) is a naturally occurring mutated variant of the apolipoprotein A1 ... Weisgraber KH, Rall SC, Bersot TP, Mahley RW, Franceschini G, Sirtori CR (25 February 1983). "Apolipoprotein A-IMilano. ...
APOA2APOA2
structures of apolipoprotein a-ii and a lipid surrogate complex provide insights into apolipoprotein-lipid interactions ... "Entrez Gene: APOA2 apolipoprotein A-II".. *^ Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan ... Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene.[5] ... apolipoprotein receptor binding. • high-density lipoprotein particle receptor binding. • cholesterol binding. • protein binding ...
APOA2APOA2
Apolipoprotein A-II is a protein that in humans is encoded by the APOA2 gene. This gene encodes apolipoprotein (apo-) A-II, ... "Entrez Gene: APOA2 apolipoprotein A-II". Pussinen PJ, Jauhiainen M, Metso J, Pyle LE, Marcel YL, Fidge NH, Ehnholm C (Jan 1998 ... Brewer HB, Lux SE, Ronan R, John KM (May 1972). "Amino acid sequence of human apoLp-Gln-II (apoA-II), an apolipoprotein ... The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result ...
13-Hydroxyoctadecadienoic acid13-Hydroxyoctadecadienoic acid
"Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosis". Nature ...
Apolipoproteína E, a enciclopedia libreApolipoproteína E, a enciclopedia libre
"Entrez Gene: APOE apolipoprotein E".. *↑ Liu CC, Liu CC, Kanekiyo T, Xu H, Bu G (Feb 2013). "Apolipoprotein E and Alzheimer ... "Alzheimer Research Forum: Meta-Analyses of apolipoprotein E AD Association Studies".. *↑ Weisgraber KH, Innerarity TL, Mahley ... Mahley RW, Rall SC (2002). "Apolipoprotein E: far more than a lipid transport protein". Annual Review of Genomics and Human ... Apolipoproteins E Medical Subject Headings (MeSH) na Biblioteca Nacional de Medicina dos EUA. ...
Low-density lipoprotein receptor-related protein 8Low-density lipoprotein receptor-related protein 8
Apolipoprotein E (ApoE) plays an important role in phospholipid and cholesterol homeostasis. After binding ApoER2, ApoE is ... Riddell DR, Sun XM, Stannard AK, Soutar AK, Owen JS (2001). "Localization of apolipoprotein E receptor 2 to caveolae in the ... Herz J (June 2009). "Apolipoprotein E receptors in the nervous system". Curr. Opin. Lipidol. 20 (3): 190-6. doi:10.1097/MOL. ... Low-density lipoprotein receptor-related protein 8 (LRP8), also known as apolipoprotein E receptor 2 (ApoER2), is a protein ...
APOMAPOM
Apolipoprotein M is a protein that in humans is encoded by the APOM gene. The protein encoded by this gene is an apolipoprotein ... "Entrez Gene: APOM apolipoprotein M". Albertella MR, Jones H, Thomson W, et al. (1997). "Localization of eight additional genes ... 2004). "Regulation of apolipoprotein M gene expression by MODY3 gene hepatocyte nuclear factor-1alpha: haploinsufficiency is ... 2005). "Leptin inhibits apolipoprotein M transcription and secretion in human hepatoma cell line, HepG2 cells". Biochim. ...
Trans fatTrans fat
Gatto LM, Sullivan DR, Samman S (May 2003). "Postprandial effects of dietary trans fatty acids on apolipoprotein(a) and ... because palm oil results in adverse changes in the blood concentrations of LDL and apolipoprotein B just as trans fat does.[191 ... higher after the trans meal than after the cis meal and that lipoprotein concentrations were enriched in apolipoprotein(a) ... of dietary fatty acids and carbohydrates on the ratio of serum total to HDL cholesterol and on serum lipids and apolipoproteins ...
APOL3APOL3
Apolipoprotein L3 is a protein that in humans is encoded by the APOL3 gene. This gene is a member of the apolipoprotein L gene ... "Entrez Gene: APOL3 apolipoprotein L, 3". Human APOL3 genome location and APOL3 gene details page in the UCSC Genome Browser. ... 2001). "Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene". J. ... Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution ...
Gladstone InstitutesGladstone Institutes
Alzheimer's disease and apolipoprotein E (apoE). Uncovered the molecular pathways that link apoE and Alzheimer's disease, and ...
APOL2APOL2
Apolipoprotein L2 is a protein that in humans is encoded by the APOL2 gene. This gene is a member of the apolipoprotein L gene ... "Entrez Gene: APOL2 apolipoprotein L, 2". Human APOL2 genome location and APOL2 gene details page in the UCSC Genome Browser. ... McGhee KA, Morris DW, Schwaiger S (2005). "Investigation of the apolipoprotein-L (APOL) gene family and schizophrenia using a ... Monajemi H, Fontijn RD, Pannekoek H, Horrevoets AJ (2002). "The apolipoprotein L gene cluster has emerged recently in evolution ...
APOL6APOL6
Apolipoprotein L6 is a protein that in humans is encoded by the APOL6 gene. This gene is a member of the apolipoprotein L gene ... "Entrez Gene: APOL6 apolipoprotein L, 6". Human APOL6 genome location and APOL6 gene details page in the UCSC Genome Browser. ... Liu Z, Lu H, Jiang Z, Pastuszyn A, Hu CA (Jan 2005). "Apolipoprotein l6, a novel proapoptotic Bcl-2 homology 3-only protein, ... "The human apolipoprotein L gene cluster: identification, classification, and sites of distribution". Genomics. 74 (1): 71-8. ...
AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
Apolipoproteins CApolipoproteinsApolipoproteins AApolipoproteins BApolipoprotein A-IApolipoprotein A-IIApolipoproteins EApolipoprotein C-IIApolipoprotein C-IIILipoproteins, HDLApolipoproteins DLipoproteinsApolipoprotein C-ICholesterolLipoproteins, VLDLTriglyceridesLipidsApolipoprotein B-100Apolipoprotein B-48Cholesterol, HDLLipoproteins, HDL3Tangier DiseasePhosphatidylcholine-Sterol O-AcyltransferaseLipoproteins, LDLNephelometry and TurbidimetryATP Binding Cassette Transporter 1Cholesterol EstersIsoelectric FocusingReceptors, LipoproteinLipid MetabolismChylomicronsCholesterol, LDLPhospholipidsUltracentrifugationHypolipoproteinemiasLipoproteins, HDL2Lipoprotein(a)LymphElectrophoresis, Polyacrylamide GelApoproteinsHyperlipidemiasLiverImmunodiffusionLipoprotein LipaseTrioleinHyperlipoproteinemia Type IVPhosphatidylcholinesKineticsATP-Binding Cassette TransportersHyperlipoproteinemiasApolipoprotein E3Chemistry, ClinicalCholesterol, VLDLHypertriglyceridemiaCholesterol Ester Transfer ProteinsLipoproteins, IDLReference ValuesScavenger Receptors, Class BFreeze DryingEthinyl EstradiolParticle SizeImmunoassaySerum Amyloid A ProteinDietary FatsMicroscopy, ElectronImmunoelectrophoresisHyperlipoproteinemia Type VAbetalipoproteinemiaDimyristoylphosphatidylcholineReceptors, ScavengerAmino Acid SequenceOleic AcidChromatography, GelMolecular WeightArteriosclerosisBiological TransportLipolysisSterol O-AcyltransferaseRats, Inbred StrainsCallitrichinaeHigh-Density Lipoproteins, Pre-betaLipaseLiposomesReceptors, LDLOleic AcidsCarrier ProteinsMolecular Sequence DataLecithin Acyltransferase DeficiencyHyperlipidemia, Familial CombinedProtein BindingAntigens, CD36ButterHyperlipoproteinemia Type IIEsterificationGlycoproteinsEmulsionsSalmonidaeBinding, Competitive
Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease...Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease...
H. Kharrazi, A. Vaisi Raygani, A.R. Sabokroh, T. Pourmotabbed, Association between apolipoprotein E polymorphism and coronary ... Cholesterol ester transfer protein, apolipoprotein E and lipoprotein lipase genotypes in patients with coronary artery disease ... apolipoprotein E (Apo E) and lipoprotein lipase (LPL). The relationship between CETP MspI, apo E and LPL PvuII gene ...
more infoonlinelibrary.wiley.com
Correlations between Apolipoprotein D (APOD) and DESCorrelations between Apolipoprotein D (APOD) and DES
DES regulates expression of avian apolipoprotein D during regression and recrudescence of the oviduct and epithelial-derived ... Correlations between Apolipoprotein D (APOD) and DES. Diethylstilbestrol regulates expression of avian apolipoprotein D during ... Apolipoprotein D featured image credit opm.phar.umich.edu.. DES DIETHYLSTILBESTROL RESOURCES. *Source DES and epigenetics ... Apolipoprotein D (APOD) is a glycoprotein which is widely expressed in mammalian tissues. It is structurally and functionally ...
more infodiethylstilbestrol.co.uk
A structural model for apolipoprotein C-II amyloid fibrils : experimental characterization and molecular dynamics simulations ...A structural model for apolipoprotein C-II amyloid fibrils : experimental characterization and molecular dynamics simulations ...
Lipid-free human apolipoprotein C-II (apoC-II) forms characteristic amyloid fibrils and is one of several apolipoproteins that ... A structural model for apolipoprotein C-II amyloid fibrils : experimental characterization and molecular dynamics simulations ... A structural model for apolipoprotein C-II amyloid fibrils : experimental characterization and molecular dynamics simulations. ...
more infoedoc.unibas.ch
Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain | Reproductive Biology...Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain | Reproductive Biology...
Apolipoprotein D (ApoD) is a lipocalin involved in several processes including lipid transport, but its modulation during human ... From: Modulation of Apolipoprotein D levels in human pregnancy and association with gestational weight gain ...
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Silver-enhanced radial immunodiffusion assay of plasma apolipoprotein by B Y. Ishida and B PaigenSilver-enhanced radial immunodiffusion assay of plasma apolipoprotein" by B Y. Ishida and B Paigen
This modification permits the quantification of apolipoproteins A-I, A-II, C, and E at levels of 0.2-1.0 mg/dl in plasma ... This modification permits the quantification of apolipoproteins A-I, A-II, C, and E at levels of 0.2-1.0 mg/dl in plasma ... Apolipoproteins, Immunodiffusion: mt, Mice, Sensitivity-and-Specificity, Silver, Stains-and-Staining, SUPPORT-NON-U-S-GOVT, ... Ishida, B Y. and Paigen, B, " Silver-enhanced radial immunodiffusion assay of plasma apolipoproteins." (1992). Faculty Research ...
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Apolipoprotein C-II deficiency (APOC2) DNA Test Lab Cost INR 30000.00 best genetic offer discount price Delhi Mumbai Kolkata...Apolipoprotein C-II deficiency (APOC2) DNA Test Lab Cost INR 30000.00 best genetic offer discount price Delhi Mumbai Kolkata...
Apolipoprotein C-II deficiency (APOC2) Test Cost INR 30000.00 Surat Pune Jaipur Lucknow Kanpur Nagpur Visakhapatnam Indore ... Apolipoprotein C-II deficiency (APOC2) Test Description. Apolipoprotein C-II deficiency (APOC2) Apolipoprotein C-II deficiency ... Apolipoprotein C-II deficiency (APOC2) TEST DETAILS. Deatils about the test Apolipoprotein C-II deficiency (APOC2). *What is ... Make the payment Online for Apolipoprotein C-II deficiency (APOC2). * Fill the Form with your details for Apolipoprotein C-II ...
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Genetic analysis of a Japanese family with normotriglyceridemic abetalipoproteinemia indicates a lack of linkage to the...Genetic analysis of a Japanese family with normotriglyceridemic abetalipoproteinemia indicates a lack of linkage to the...
... analysis of a Japanese family with normotriglyceridemic abetalipoproteinemia indicates a lack of linkage to the apolipoprotein ... analysis of a Japanese family with normotriglyceridemic abetalipoproteinemia indicates a lack of linkage to the apolipoprotein ...
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Apolipoprotein C4 - WikipediaApolipoprotein C4 - Wikipedia
Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene.[5][6] ... Apolipoprotein (apo)C4 gene is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted ... "Entrez Gene: apolipoprotein C-IV".. *^ Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and ... 2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical ...
more infoen.wikipedia.org
Apolipoprotein C2 - WikipediaApolipoprotein C2 - Wikipedia
Apolipoprotein C2 or apolipoprotein C-II is a protein that in humans is encoded by the APOC2 gene. secreted in plasma where it ... "A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency". J. Clin. Invest. ... Familial apolipoprotein CII deficiency associated with premature vascular disease". J. Clin. Invest. 80 (6): 1597-606. doi: ... "Structure of apolipoprotein C-IIToronto, a nonfunctional human apolipoprotein". Proc. Natl. Acad. Sci. U.S.A. 84 (1): 270-3. ...
more infoen.wikipedia.org
Apolipoprotein B100: MedlinePlus Medical EncyclopediaApolipoprotein B100: MedlinePlus Medical Encyclopedia
Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein B100 (apoB100) is a protein that plays a role in moving cholesterol around your body. It is a form of low ... Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond ... Regulation and clearance of apolipoprotein B-containing lipoproteins. In: Ballantyne CM, ed. Clinical Lipidology: A Companion ...
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Apolipoprotein CII: MedlinePlus Medical EncyclopediaApolipoprotein CII: MedlinePlus Medical Encyclopedia
Apolipoprotein CII (apoCII) is a protein found in large fat particles that the gastrointestinal tract absorbs. It is also found ... ApoCII; Apoprotein CII; ApoC2; Lipoprotein lipase deficiency - apolipoprotein CII; Chylomicronemia syndrome - apolipoprotein ... Apolipoprotein measurements may provide more detail about your risk for heart disease, but the added value of this test beyond ... Apolipoprotein CII (apoCII) is a protein found in large fat particles that the gastrointestinal tract absorbs. It is also found ...
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Apolipoprotein News, ResearchApolipoprotein News, Research
The key is a naturally occurring protein called apolipoprotein A-I binding protein (AIBP). AIBP binds to toll-like receptor 4 ( ...
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What is apolipoprotein AI amyloidosis (apoAI)?What is apolipoprotein AI amyloidosis (apoAI)?
Apolipoprotein AI amyloidosis (apoAI) is an autosomal dominant amyloidosis caused by point mutations in the apoAI gene. Usually ... encoded search term (What is apolipoprotein AI amyloidosis (apoAI)?) and What is apolipoprotein AI amyloidosis (apoAI)? What to ... What is apolipoprotein AI amyloidosis (apoAI)?. Updated: May 09, 2019 * Author: Robert O Holmes, Jr, DO; Chief Editor: Herbert ... Apolipoprotein AI amyloidosis (apoAI) is an autosomal dominant amyloidosis caused by point mutations in the apoAI gene. Usually ...
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Apo B (Apolipoprotein B)Apo B (Apolipoprotein B)
The apolipoprotein B (Apo B) is a protein involved in the metabolism of lipids. The apo B test may be used, along with other ... Apolipoprotein B-100 (also called apolipoprotein B or apo B) is a protein that is involved in the metabolism of lipids and is ... Apolipoproteins combine with lipids to transport them throughout the bloodstream. Apolipoproteins provide structural integrity ... The apolipoprotein B (apo B) test is used, along with other lipid tests, to help determine an individuals risk of developing ...
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Lipid and apolipoprotein in cord blood | SpringerLinkLipid and apolipoprotein in cord blood | SpringerLink
... a series of Sicilian neonates was studied in order to investigate about the distribution of serum lipid and apolipoprotein at ... 1990) Lipid and apolipoprotein in cord blood. In: Descovich G., Gaddi A., Magri G., Lenzi S. (eds) Atherosclerosis and ... McConathy, W.J., Lane, D.M., (1980) "Studies on the apolipoproteins and lipoproteins of cord serum", Pediatr. Res., 14, 757-61. ... In conclusion lipid and apolipoprotein distributions in Sicilian newborns are not different from that of other population and ...
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Apolipoprotein A-IV (O46409) | InterPro | EMBL-EBIApolipoprotein A-IV (O46409) | InterPro | EMBL-EBI
InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their individual strengths to produce a powerful integrated database and diagnostic tool.
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Apolipoprotein A/E (IPR000074) | InterPro | EMBL-EBIApolipoprotein A/E (IPR000074) | InterPro | EMBL-EBI
Exchangeable apolipoproteins (apoA, apoC and apoE) have the same genomic structure and are members of a multi-gene family that ... ApoA1, ApoA4 and Apo5 are part of the APOA1/C3/A4/A5 gene cluster on chromosome 11 [PMID: 15108119]. Apolipoproteins function ... Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E.. Science 252 1817-22 1991 ... Contributions of domain structure and lipid interaction to the functionality of exchangeable human apolipoproteins.. Prog. ...
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APOA1 apolipoprotein A1 [Homo sapiens (human)] - Gene - NCBIAPOA1 apolipoprotein A1 [Homo sapiens (human)] - Gene - NCBI
APOA1 apolipoprotein A1 [Homo sapiens] APOA1 apolipoprotein A1 [Homo sapiens]. Gene ID:335 ... Title: Apolipoprotein B/apolipoprotein A1 ratio and mortality among incident peritoneal dialysis patients. ... apolipoprotein A1provided by HGNC. Primary source. HGNC:HGNC:600 See related. Ensembl:ENSG00000118137 MIM:107680; Vega: ... Tertiary structure of apolipoprotein A-I in nascent high-density lipoproteins. Pourmousa M, et al. Proc Natl Acad Sci U S A, ...
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Apolipoprotein - WikipediaApolipoprotein - Wikipedia
Apolipoprotein synthesis in the intestine is regulated principally by the fat content of the diet. Apolipoprotein synthesis in ... There are also intermediate-density lipoproteins formed by Apolipoprotein E. There are six classes of apolipoproteins and ... There are two major types of apolipoproteins. Apolipoproteins B form low-density lipoprotein (sometimes referred to as "bad ... Apolipoprotein L Saito H, Lund-Katz S, Phillips MC (July 2004). "Contributions of domain structure and lipid interaction to the ...
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Apolipoprotein E in Alzheimers disease: an update. - PubMed - NCBIApolipoprotein E in Alzheimer's disease: an update. - PubMed - NCBI
Apolipoprotein E in Alzheimers disease: an update.. Yu JT1, Tan L, Hardy J. ... Apolipoprotein E (APOE) has been irrefutably recognized as the major genetic risk factor, with semidominant inheritance, for ...
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Absolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction | SpringerLinkAbsolute Quantification of Plasma Apolipoproteins for Cardiovascular Disease Risk Prediction | SpringerLink
Apolipoproteins regulate lipid metabolism, adipose tissue, and energy production and serve major... ... Apolipoproteins have important structural and functional roles in several lipoprotein particles. ... Horejsi B, Ceska R (2000) Apolipoproteins and atherosclerosis. Apolipoprotein E and apolipoprotein(a) as candidate genes of ... Apolipoproteins have important structural and functional roles in several lipoprotein particles. Apolipoproteins regulate lipid ...
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NHANES 2011-2012: Apolipoprotein B Data Documentation, Codebook, and FrequenciesNHANES 2011-2012: Apolipoprotein B Data Documentation, Codebook, and Frequencies
LBXAPB - Apolipoprotein (B) (mg/dL). Variable Name: LBXAPB. SAS Label: Apolipoprotein (B) (mg/dL). English Text: Apolipoprotein ... LBDAPBSI - Apolipoprotein (B) (g/L). Variable Name: LBDAPBSI. SAS Label: Apolipoprotein (B) (g/L). English Text: Apolipoprotein ... Apolipoprotein B (ApoB_G) Data File: ApoB_G.xpt First Published: January 2014. Last Revised: NA ... Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. ...
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NHANES 2007-2008: Apolipoprotein B Data Documentation, Codebook, and FrequenciesNHANES 2007-2008: Apolipoprotein B Data Documentation, Codebook, and Frequencies
LBXAPB - Apolipoprotein (B) (mg/dL). Variable Name: LBXAPB. SAS Label: Apolipoprotein (B) (mg/dL). English Text: Apolipoprotein ... LBDAPBSI - Apolipoprotein (B) (g/L). Variable Name: LBDAPBSI. SAS Label: Apolipoprotein (B) (g/L). English Text: Apolipoprotein ... A crossover study was performed to compare the 2007-2008 Apolipoprotein B data to the 2005-2006 Apolipoprotein B data. The Dade ... Apolipoprotein B (ApoB_E) Data File: ApoB_E.xpt First Published: July 2010. Last Revised: NA Note: See Analytic Note on ...
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Conversion of apolipoprotein-spec... preview & related info | MendeleyConversion of apolipoprotein-spec... preview & related info | Mendeley
HDL3species containing both apolipoprotein A-I and apolipoprotein A-II, and HDL3(AI w/o AII), HDL3species containing ... initially with three apolipoprotein A-I, to larger particles with four apolipoprotein A-I per particle. © 1989. ... Conversion of apolipoprotein-specific high-density lipoprotein populations during incubation of human plasma. *Nichols A ... Nichols, A. V., Blanche, P. J., Shore, V. G., & Gong, E. L. (1989). Conversion of apolipoprotein-specific high-density ...
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Apolipoproteins | ProSpecApolipoproteins | ProSpec
Apolipoprotein-D Human Recombinant, Human Apolipoprotein-J, Apolipoprotein-J Canine Recombinant ... ProSpecs Apolipoproteins include: Clusterin Human Recombinant, Clusterin Rat Recombinant, ... About Apolipoprotein:. The binding of lipids (soluble oil molecules) and cholesterol to Apoliproteins result in the formation ... 6 main classes of apolipoproteins are APOA, APOB, APOC, APOD, APOE and APOH. APOA1 takes an important role in the return of ...
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AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation Science
Apolipoproteins CApolipoproteinsApolipoproteins AApolipoproteins BApolipoprotein A-IApolipoprotein A-IIApolipoproteins EApolipoprotein C-IIApolipoprotein C-IIILipoproteins, HDLApolipoproteins DLipoproteinsApolipoprotein C-ICholesterolLipoproteins, VLDLTriglyceridesLipidsApolipoprotein B-100Apolipoprotein B-48Cholesterol, HDLLipoproteins, HDL3Tangier DiseasePhosphatidylcholine-Sterol O-AcyltransferaseLipoproteins, LDLNephelometry and TurbidimetryATP Binding Cassette Transporter 1Cholesterol EstersIsoelectric FocusingReceptors, LipoproteinLipid MetabolismChylomicronsCholesterol, LDLPhospholipidsUltracentrifugationHypolipoproteinemiasLipoproteins, HDL2Lipoprotein(a)LymphElectrophoresis, Polyacrylamide GelApoproteinsHyperlipidemiasLiverImmunodiffusionLipoprotein LipaseTrioleinHyperlipoproteinemia Type IVPhosphatidylcholinesKineticsATP-Binding Cassette TransportersHyperlipoproteinemiasApolipoprotein E3Chemistry, ClinicalCholesterol, VLDLHypertriglyceridemiaCholesterol Ester Transfer ProteinsLipoproteins, IDLReference ValuesScavenger Receptors, Class BFreeze DryingEthinyl EstradiolParticle SizeImmunoassaySerum Amyloid A ProteinDietary FatsMicroscopy, ElectronImmunoelectrophoresisHyperlipoproteinemia Type VAbetalipoproteinemiaDimyristoylphosphatidylcholineReceptors, ScavengerAmino Acid SequenceOleic AcidChromatography, GelMolecular WeightArteriosclerosisBiological TransportLipolysisSterol O-AcyltransferaseRats, Inbred StrainsCallitrichinaeHigh-Density Lipoproteins, Pre-betaLipaseLiposomesReceptors, LDLOleic AcidsCarrier ProteinsMolecular Sequence DataLecithin Acyltransferase DeficiencyHyperlipidemia, Familial CombinedProtein BindingAntigens, CD36ButterHyperlipoproteinemia Type IIEsterificationGlycoproteinsEmulsionsSalmonidaeBinding, Competitive
ApoDAPOC2HumanLevelsRegulatesGeneAPOA1Lipids and apolipoproteinsApoBMetabolismCoronary heart dFamilialAPODGeneticRecombinantAntibodyAmyloidosisLevels of apolipoproteinParticlesAntibodiesSpeciesSerum apolipoproteinPlasma apolipoproteinSpecific apolipoproteinsApoMMimeticsModulateMRNARenalSecretionPeripheralStructuralAmyloidAmphipathicAmino acidsTissuesPrecursorHuman serumReceptor ligandsCardiovascular risk
ApoD1
APOC24
Human1
Levels1
  • This modification permits the quantification of apolipoproteins A-I, A-II, C, and E at levels of 0.2-1.0 mg/dl in plasma samples at a sensitivity threshold of 10 ng. (jax.org)
Regulates1
  • Diethylstilbestrol regulates expression of avian apolipoprotein D during regression and recrudescence of the oviduct and epithelial-derived ovarian carcinogenesis , Domestic animal endocrinology, NCBI PubMed PMID: 25929245 , 2015 Jul. (diethylstilbestrol.co.uk)
Gene29
APOA18
Lipids and apolipoproteins4
ApoB4
Metabolism6
Coronary heart d2
  • In addition, quantitative immunological measurements of certain apolipoproteins (especially A-1 and B) have been suggested to be more accurate estimators of coronary heart disease than measurements of lipoprotein particles (especially HDL and LDL). (abcam.com)
  • Apolipoproteins A and B are risk indicators of coronary heart disease and targets for lipid-modifying therapy, such as statins. (thefreedictionary.com)
Familial1
APOD3
Genetic3
  • Hundreds of genetic polymorphisms of the apolipoproteins have been described, and many of them alter their structure and function. (wikipedia.org)
  • INTRODUCTION: Genetic polymorphisms in apolipoprotein genes may be associated with alteration in lipid profile and susceptibility to gallstone disease. (hindawi.com)
  • Trp99His, Cys116Ser, Ile118Ser, Leu120Ser amino acids exchanges were introduced at the surface of Apolipoprotein-D to enhance the protein's solubility and another three Leu23Pro, Pro133Val, Asn134Ala amino acids exchanges which facilitate its genetic manipulation. (prospecbio.com)
Recombinant2
Antibody5
Amyloidosis1
Levels of apolipoprotein1
  • Smoking cigarettes, taking diuretics, or taking medicines that contain androgens can also cause lower levels of apolipoprotein A. (ahealthyme.com)
Particles5
Antibodies4
Species3
Serum apolipoprotein2
Plasma apolipoprotein1
  • OBJECTIVE To determine plasma apolipoprotein A-IV (apoA-IV) levels and phenotype distribution in non-insulin-dependent diabetes mellitus (NIDDM) patients and to analyze the influence of apoA-IV phenotype on lipid profiles in NIDDM. (diabetesjournals.org)
Specific apolipoproteins2
ApoM3
Mimetics3
  • This comprehensive book provides not only the stages in the development of this unique and specialized field but also updates on the current state of research and development of apolipoprotein mimetics as therapeutic modalities for various lipid-mediated disorders. (springer.com)
  • Over the years Dr. Ananth has been an author in more than 200 original publications and more than 30 patents, most of which are related to the studies of apolipoprotein mimetics. (springer.com)
  • Apolipoprotein A-I mimetics and high-density lipoprotein function. (thefreedictionary.com)
Modulate1
  • The present invention relates to methods of use of phosphonate-phosphates and diphosphonates to modulate apolipoprotein E levels and the use of such compounds in therapy, including cardiovascular and neurological disease states. (freepatentsonline.com)
MRNA2
  • The agent blocks the function of the mRNA of apolipoprotein C3 and successfully treats severe hypertriglyceridaemia in phase 3 trials (Ionis Pharmaceuticals). (ovid.com)
  • Your search returned 5 apolipoprotein B mRNA editing enzyme catalytic subunit 1 ELISA ELISA Kit across 2 suppliers. (biocompare.com)
Renal1
  • Vlad C, Burlacu A, Florea L, Artene B, Badarau S, Covic A et al (2019) A comprehensive review on apolipoproteins as nontraditional cardiovascular risk factors in end-stage renal disease: current evidence and perspectives. (springer.com)
Secretion1
Peripheral1
Structural1
Amyloid1
Amphipathic3
  • However, because of their detergent-like (amphipathic) properties, apolipoproteins and other amphipathic molecules (such as phospholipids) can surround the lipids, creating the lipoprotein particle that is itself water-soluble, and can thus be carried through water-based circulation (i.e., blood, lymph). (wikipedia.org)
  • Nevertheless, due to of their amphipathic/detergent like characteristics, Apolipoproteins fence in the lipids, forming a lipoprotein particle which is soluble in water, hence travel in blood. (prospecbio.com)
  • One role is to increase the overall solubility of the lipid particle, helping it to dissolve in the aqueous environment of the blood (apolipoproteins are amphipathic, or detergent-like proteins). (labce.com)
Amino acids1
  • Using the models of two long anti-atherogenic and anti-inflammatory proteins (apolipoprotein A-I and apolipoprotein E with 243 and 299 amino acids, respectively) short mimetic peptides of 18 to 28 amino acid residues in length, which can be produced either synthetically or genetically in edible fruits and vegetables, have been shown to exert profound biological effects in a large number of animal models of diseases. (springer.com)
Tissues1
Precursor1
  • Fibrinogen alpha chain precursor and apolipoprotein a-I in urine as biomarkers for noninvasive diagnosis of calcium oxalate nephrolithiasis: a proteomics study. (medscape.com)
Human serum1
Receptor ligands1
  • Apolipoproteins can also function as enzyme co-factors (receptor ligands), facilitating the transfer of their lipid cargo to specific cells. (labce.com)
Cardiovascular risk2